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FS Lopes was born in 1969. Entered school in 1975 and University in 1987. FS Lopes graduated in Biochemistry by Faculdade de Ciências from Universidade de Lisboa in 1992. After some time as a grantee in an IBET project, she engaged on her PhD studies in Biochemistry completed in 1999 at Instituto de Tecnologia Química e Biológica. During her PhD, she had the opportunity to work for short periods in laboratories in The Netherlands and Germany. During her time as post-doc (until 2003), she started to enroll in her present subject of study, devoting also some time to teaching at the University. Her interests have since then been to understand how a commensal bacteria becomes pathogenic in special circumstances, namely in patients with lower immune capacity and subjected to antibiotic therapy. Aiming, in long term, to find new approaches and molecules to fight opportunistic nosocomial pathogens, she chose Enterococcus as a model organism. She started this path in 2000, during her post-doc, but it was in 2003 that she got a group leader position as an independent researcher. However, her first FCT project as a principal investigator was won during her post-doc. During her post-doc she was already working as an independent researcher, publishing as corresponding author and supervising her own students. Since 2003 her group grew up to comprise 9 investigators and she completed the supervision of 6 master thesis (3 of which were the old Master degree in Portugal), 6 PhD students, one post-doc and several undergraduate students. She has also been involved (in classes and tutorials) in the ITQB PhD Program since its beginning. Since her PhD, FS Lopes published several works in peer reviewed journals, presented several posters in international and national meetings and 9 oral presentations (presented either by her or her students) in international meetings and institutions abroad by invitation. She is also co-author of two book chapters. FS Lopes got financing from both National and International calls for projects, namely four FCT projects as Principal Investigator, one Era-net Pathogenomics (as the Portuguese partner in the consortium), and one bi-lateral collaboration (Pessoa Program) with France. After her PhD she managed to build strong and solid collaborations with the most prominent groups in her field which were translated into publications, and allowed training of PhD students. After several years as a researcher, she worked 3 years as the Education Manager of the PhD Program in Bioengineering Systems of the MIT-Portugal Program. She recently embraced a new challenge, working as a researcher at the National Intitute of Health Doutor Ricardo Jorge, Portugal, in the B1MG Prtoject, a Coordination and Support Action for the 1+ Million Genomes Initiative. FS Lopes is also often invited to referee manuscripts for publication in high impact factor journals of her area and invited to referee PhD thesis discussions.
Identificação

Identificação pessoal

Nome completo
Maria de Fátima Silva Lopes

Nomes de citação

  • Lopes, Maria

Identificadores de autor

Ciência ID
5F19-A4BC-9A2D
ORCID iD
0000-0003-1243-8424

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
Formação
Grau Classificação
2000 - 2003
Concluído
Microbiology (Pós-doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1994 - 1999
Concluído
Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1987 - 1992
Concluído
Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
17
Projetos

Projeto

Designação Financiadores
2020/06/01 - 2023/08/31 Beyond 1M Genomes
951724
Investigador
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
European Commission
Concluído
2006 - 2010 Virulence of food enterococci: adding new pieces to the puzzling subject of enterococci as opportunistic pathogens. PI do projecto e única equipa envolvida
POCTI/CVT/67270/2006
Fundação para a Ciência e Tecnologia
2006 - 2009 Large scale screening of potential key factors involved in the commensalism / virulence transition of Enterococcus faecalis
ERA-PTG/0001/2006
Research Executive Agency
2004 - 2007 Antibiotic stress by vancomycin on enterococci: risk assessment of food safety
POCI/CVT/59636/2004
Fundação para a Ciência e Tecnologia
2004 - 2007 Sense and sensibility: looking for the missing link in lactic acid bacteria stress response pathways
POCI/BIA-BCM/60643/2004
Fundação para a Ciência e Tecnologia
2001 - 2004 Enterococci in Food: Antibiotics and Safety
POCTI/AGR/39371/2001
Fundação para a Ciência e Tecnologia
Produções

Publicações

Artigo em revista
  1. • Costa, A., Cardoso, M. L., Lopes, M. F., Vicente, A., & impact (WP5), em nome da equipa do projeto B. 1 M. G.-D. P. M.. "Recomendações para a Implementação da medicina genómica nos sistemas de saúde: principais conclusões das Country Exchange Visits ao Reino Unido, Estónia e Finlândia". (2023):
  2. Lopes, Maria. "Enterococcus faecalis V583 LuxS/AI-2 system is devoid of role in intra-species quorum-sensing but contributes to virulence in a Drosophila host model". [] (2018): http://dx.doi.org/10.1101/344176.
    10.1101/344176
  3. Lopes, Maria. "The contribution of melanization to Drosophila survival changes with Enterococcus faecalis V583 genomic content". [] (2018): http://dx.doi.org/10.1101/329144.
    10.1101/329144
  4. Lopes, Maria. "Evaluation of antimicrobial resistance and virulence of enterococci from equipment surfaces, raw materials, and traditional cheeses". International Journal of Food Microbiology (2016):
    DOI: 10.1016/j.ijfoodmicro.2016.07.020
  5. Lopes, Maria. "Enterococcus faecalis zinc responsive proteins mediate bacterial defense against zinc overload, lysozyme and oxidative stress". Microbiology (2014):
    Doi:10.1099/mic0.080341-0
  6. Maria de Fátima Silva Lopes. "Transcriptomic study reveals new pathways and genes involved in Enterococcus faecalis V583 response to a therapeutic dose of vancomycin.". Archives of Cinical Microbiology (2013):
    doi: 10.3823/274
  7. Maria de Fátima Silva Lopes. "EfaR is a major regulator of Enterococcus faecalis manganese transporters and influences processes involved in host colonization and infection". Infection and Immunity (2013):
    DOI: 10.1128/IAI.06377-11
  8. Maria de Fátima Silva Lopes. "Chloramphenicol.cyclodextrin inclusion compounds: co-dissolution and mechanochemical preparations and antibacterial action". CrystEngComm (2013):
    10.1039/C3CE26414A
  9. Maria de Fátima Silva Lopes. "Enterococcus faecalis prophage dynamics and contributions to pathogenic traits". Plos Pathogens (2013):
    doi:10.1371/journal.pgen.1003539.
  10. Maria de Fátima Silva Lopes. "High-level vancomycin resistant Enterococcus faecium related to humans and pigs found in dust from pig breeding facilities". (2013):
    https://doi.org/10.1016/j.vetmic.2012.07.034
  11. Maria de Fátima Silva Lopes. "Drosophila host model reveals new Enterococcus faecalis quorum-sensing associated virulence factors". PlosOne (2013):
    doi:10.1371/journal.pone.0064740.
  12. Maria de Fátima Silva Lopes. "Phage endolysins with a broad antimicrobial activity against Enterococcus faecalis clinical Strains". Microbial Drug Resistance (2012):
    10.1089/mdr.2012.0024
  13. Maria de Fátima Silva Lopes. "Incongruence between the cps type 2 genotype and host-related phenotypes of an Enterococcus faecalis food isolate". International Journal of Food Microbiology (2012):
    10.1016/j.ijfoodmicro.2012.07.006
  14. Maria de Fátima Silva Lopes. "Incongruent gelatinase phenotype and genotype in Enterococcus faecalis is due to shutting off the ability to respond to the GBAP quorum-sensing signal". Microbiology (2012):
    10.1099/mic.0.055574-0
  15. Maria de Fátima Silva Lopes. "Hospital-adapted clonal complex 17 Enterococcus faecium found among sand enterococcal isolates". Journal of Environmental Protection (2012):
    DOI: 10.4236/jep.2012.31010
  16. Maria de Fátima Silva Lopes. "Large-scale screening of a targeted Enterococcus faecalis mutant library identifies envelop fitness factors". PlosOne (2011):
    https://doi.org/10.1371/journal.pone.0029023
  17. Maria de Fátima Silva Lopes. "Identification of a new gene, vanV, in vanB operons of Enterococcus faecalis". International Journal of Antimicrobial Agents (2011):
    https://doi.org/10.1016/j.ijantimicag.2011.01.024
  18. Maria de Fátima Silva Lopes. "Involvement, and dissemination, of the enterococcal small multidrug resistance transporter QacZ in resistance to quaternary ammonium compounds". Journal of Antimicrobial Chemotherapy (2011):
    https://doi.org/10.1093/jac/dkq460
  19. Maria de Fátima Silva Lopes. "Impact of manganese, copper and zinc ions on the transcriptome of the nosocomial pathogen Enterococcus faecalis V583". PlosOne (2011):
    https://doi.org/10.1371/journal.pone.0026519
  20. Maria de Fátima Silva Lopes. "Cyclodextrins improve the antimicrobial activity of the chloride salt of Ruthenium(II) chloro-phenanthrolinetrithiacyclononane". BioMetals (2009):
    https://doi.org/10.1007/s10534-009-9211-x
  21. Maria de Fátima Silva Lopes. "Proposal for a reliable enterococcal cytolysin production assay avoiding apparent incongruence between phenotype and genotype". Journal of Medical Microbiology (2009):
    https://doi.org/10.1099/jmm.0.006361-0
  22. Maria de Fátima Silva Lopes. "Study on the dissemination of the bcrABDR cluster in Enterococcus spp. reveals that the BcrAB transporter is sufficient to confer high-level bacitracin resistance". International Journal of Antimicrobial Agents (2009):
    https://doi.org/10.1016/j.ijantimicag.2009.02.008
  23. Maria de Fátima Silva Lopes. "Virulence of Enterococcus faecalis dairy strains in an insect model: the role of fsrB and gelE". Microbiology (2009):
    https://doi.org/10.1099/mic.0.030775-0
  24. Maria de Fátima Silva Lopes. "Enterococcus hirae causing wound infections in a hospital". JCCM (2008):
    doi:10.1086/367711
  25. Maria de Fátima Silva Lopes. "An investigation of the bacteriocinogenic potential of lactic acid bacteriaassociated with wheat (Triticum durum) kernels andnon-conventional flours". LWT-Food Science and Technology (2008):
    https://doi.org/10.1016/j.lwt.2007.07.022
  26. Maria de Fátima Silva Lopes. "Vancomycin susceptible dairy and clinical enterococcal isolates carry vanA and vanB genes". International Journal of Food Microbiology (2007):
    https://doi.org/10.1016/j.ijfoodmicro.2006.08.010
  27. Maria de Fátima Silva Lopes. "Granular layer in the periplasmic space of Gram-positive bacteria and fine structures of Enterococcus gallinarum and Streptococcus gordonii septa revealed by cryo-electron microscopy of vitreous sections". Journal of Bacteriology (2006):
    doi: 10.1128/JB.00391-06
  28. Maria de Fátima Silva Lopes. "Activity and expression of a virulence factor, gelatinase, in dairy enterococci". (2006):
    https://doi.org/10.1016/j.ijfoodmicro.2006.09.004
  29. Maria de Fátima Silva Lopes. "Antimicrobial Resistance Profiles of Dairy and Clinical Isolates and Type Strains of Enterococci". International Journal of Food Microbiology (2005):
    https://doi.org/10.1016/j.ijfoodmicro.2004.12.025
  30. Maria de Fátima Silva Lopes. "Virulence factors in food, clinical and reference enterococci: a common trait in the genus". Systematic and Applied Microbiology (2003):
    https://doi.org/10.1078/072320203322337263
  31. Maria de Fátima Silva Lopes. "Comparative study using type strains and clinical and food isolates to examine hemolytic activity and occurrence of the cyl operon in enterococci". (2003):
    doi: 10.1128/JCM.41.6.2569-2576.2003
  32. Maria de Fátima Silva Lopes. "Gentamicin resistance in dairy and clinical enterococcal isolates and in reference strains". Journal of Antimicrobial Chemotherapy (2003):
    https://doi.org/10.1093/jac/dkg304
  33. Maria de Fátima Silva Lopes. "Characterization of a highly thermostable extracellular lipase from Lactobacillus plantarum". International Journal of Food Microbiology (2002):
    https://doi.org/10.1016/S0168-1605(02)00013-2
  34. Maria de Fátima Silva Lopes. "Influence of environmental factors on lipase production by Lactobacillus plantarum". Applied Microbiology and Biotechnology (1999):
    10.1007/s002530051389
  35. Maria de Fátima Silva Lopes. "Registered Designation of Origin Area of Fermented Food Products Defined by Microbial Phenotypes and Artificial Neural Networks". Applied and Environmental Microbiology (1999):
    10.1128/aem.65.10.4484-4489.1999
  36. Maria de Fátima Silva Lopes. "Processing of extracellular lipase of Lactobacillus plantarum: involvement of a metalloprotease". FEMS Microbiology Letters (1999):
    https://doi.org/10.1111/j.1574-6968.1999.tb13701.x
  37. Maria de Fátima Silva Lopes. "On the mechanisms of genotoxicity and metabolism of quercetin". Mutagenesis (1994):
Capítulo de livro
  1. Lopes, Maria. "Insights on Enterococcus biofilm factors from expression studies". 2015.
  2. • Lopes MFS (2015), “Insights on Enterococcus biofilm factors from expression studies” in Impact of biofilms in health:. "Insights on Enterococcus biofilm factors from expression studies” in Impact of biofilms in health: a transcriptomics perspective". In Impact of Biofilms in Health a Transcriptomic Perspective. 2015.
    Publicado
  3. Maria de Fátima Silva Lopes. "Post-genomic strategies towards evaluation of pathogenicity potential". 2012.
  4. Lopes, MFS, Carrilero, L, Gonzalez-Zorn, B (2012) Post-genomic strategies towards evaluation of pathogenicity potential,. "Post-genomic strategies towards evaluation of pathogenicity potential". In Enterococcus and Safety. 2012.
    Publicado
Relatório
  1. Lopes, F., Costa, A., Cardoso, M. L., Konopko, M., Merchant, A., Tseng, Y.-Y., Scollen, S., & Vicente, A. (2023). Beyond. 2023. Beyond 1 million genomes (B1MG) D5.2 Roadmap and guidance tool for countries.
  2. Lopes, F., Costa, A., Cardoso, M. L., Konopko, M., Merchant, A., Tseng, Y.-Y., Scollen, S., & Vicente, A. (2023). Beyond. 2023. Beyond 1 million genomes (B1MG) A Roadmap for Genomics in Healthcare.
  3. Costa, A., Cardoso, M. L., Konopko, M., Pérez Sitjà, X., Lopes, M. de F., Merchant, A., Santos, O., Bourbon, M., Thorogo. 2023. B1MG - D5.1 B1MG maturity level model and country-specific alignment within the model.
  4. Imaz-Iglesia, I., Sánchez-Piedra, C. A., Custers, I., Gonçalves, F., Vicente, A., Merchant, A., Villari, P., & Migliara,. 2023. Beyond 1 Million Genomes (B1MG) D5.3 Economic models methodology and case studies.
  5. Arshiya Merchant, Maria de Fátima Lopes, Alexandra Costa, Melissa Konopko, Maria Luís Cardoso, Xènia Pérez Sitja, Mafald. 2023. Report: B1MG Country Exchange Visits. https://b1mg-project.eu/images/pdf/B1MG%20WP5%20Country%20Exchange%20Visit%20Report.docx.pdf.
  6. Maria Fátima Lopes, Arshiya Merchant, Alexandra Costa, Xènia Perez, Maria Luís Cardoso, Melissa Konopko, Mafalda Bourbon. 2022. Genomics in healthcare: key issues for implementation. https://b1mg-project.eu/images/pdf/Policy_Brief_Genomics_in_Healthcare_2022.pdf.
Resumo em conferência
  1. • Lopes, F., Pontes, A., Maria Leila Cardoso, Custers, I. M., Merchant, A., Konopko, M., S Scollen, & Vicente, A. M. (20. "Roadmap for implementation of genomics in healthcare: towards equity in access to genomics". 2023.
    Publicado
  2. • Costa, A., Merchant, A., Lopes, M., Konopko, M., Cardoso, M., Sitjà, X., Bourbon, M., Scollen, S., & Vicente, A. (2022. "Key issues for implementation of Genomics in Healthcare: a Policy Brief". 2022.
    Publicado