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Pedro Gomes is a dynamic biomedical researcher with extensive experience across different scientific disciplines (Pharmacology, Physiology, Biochemistry, Endocrinology and Aging) and with a broad set of technical skills in cellular and animal models of cardiometabolic diseases. After obtaining his PhD in Human Biology at the Faculty of Medicine of University of Porto (FMUP; Portugal), he subsequently conducted postdoctoral training at the UCLA School of Medicine (USA) and the School of Health Sciences at the University of Minho (Portugal), where he was exposed to advanced technologies, acquired new skills and established a relevant contact network. His profile and initiative have allowed him to be selected for a 5-year Assistant Researcher position (Programa Ciencia 2007/8), a nation-wide governmental initiative promoting research of excellence, at the FMUP, and was later selected for a similar position at the Center for Neuroscience and Cell Biology at the University of Coimbra. He has a proven track record of achieving significant results as demonstrated by 3 book chapters and 50 papers in international peer-reviewed journals (cumulative impact factor = 263; ~1400 citations; h index = 22; Google Scholar). Among them, 41 (82%) are as first, last or corresponding author, and 44 (88%) are in the Q1 quartile. As an important component of dissemination of his research outputs, he has participated in numerous national and international meetings being an author/coauthor of 49 oral communications and 95 journal proceedings. He maintains collaborations with leading scientists in the fields of metabolism and sirtuin biology, such as Tiago Fleming Outeiro (Univ. Groningen, Germany), Ruben Nogueiras (Univ. Santiago Compostela, Spain), and Maria Luz Martínez-Chantar (CIC bioGUNE, Spain). He is a member of the editorial board of 3 journals and also serves as a reviewer for several scientific journals. During his career, he has participated as a team member in 12 research projects and has been responsible for MSc and PhD student training and supervision. He is an Invited Assistant Professor of Pharmacology at the FMUP and has participated as lecturer in several MSc and PhD programs and in academic examining committees of MSc and PhD thesis. He has been awarded several prizes, including the prestigious Gulbenkian Science Award. His research has consistently addressed fundamental questions of biological and clinical relevance and his current research efforts as a PhD Researcher at the Faculty of Medicine of the University of Coimbra are focused on the role of mammalian sirtuin deacetylases in cardiometabolic diseases. He also provides expert consulting services to an international pharmaceutical company in the therapeutic application of small-molecule sirtuin modulators. Overall, he has achieved a high level of proficiency in terms of communication, management and leadership skills, and proven ability to manage multiple responsibilities in a fast-paced environment.
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Identificação

Identificação pessoal

Nome completo
António Pedro Barros Gomes

Nomes de citação

  • Gomes, Pedro
  • Gomes, P

Identificadores de autor

Ciência ID
5514-887A-7FDC
ORCID iD
0000-0003-1766-9133

Endereços de correio eletrónico

  • pgomes@med.up.pt (Profissional)
  • pgomes70@gmail.com (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Fisiologia
  • Ciências Médicas e da Saúde - Medicina Clínica - Endocrinologia e Metabolismo
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1998/03/01 - 2002/07/29
Concluído
 Biologia Humana (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Faculdade de Medicina, Portugal
"Regulation of sodium transepithelial flux and intracellular pH by monoamines and immediate precursors." (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
1996/04/16
Concluído
 Engenharia Biológica (Licenciatura)
Universidade do Minho Escola de Engenharia, Portugal
"n.a." (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/03/15 - Atual Investigador Contratado (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/01 - 2019/03/14 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/10/01 - 2018/09/30 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/11/01 - 2015/06/30 Investigador Auxiliar Convidado (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/11/01 - 2013/10/01 Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Centro de Farmacologia e Biopatologia Química, Portugal
2007/01/01 - 2008/10/31 Pós-doutorado (Investigação) Universidade do Porto Faculdade de Medicina, Portugal
2006/01/01 - 2006/12/31 Pós-doutorado (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004/01/01 - 2005/12/31 Pós-doutorado (Investigação) University of California Los Angeles, Estados Unidos
2002/02/01 - 2002/04/30 Investigador visitante (Investigação) Georgetown University, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/09/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade do Porto, Portugal
2008/10/01 - 2011/09/01 Assistente (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10/01 - 2018/09/30 Postdoctoral fellow (fellowship from FCT) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/01 - 2015/09/30 Invited Researcher fellowship (Bolsa de Cientista Convidado) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1998/03/01 - 2002/02/28 PhD student. PhD fellowship of the Foundation for Science and Technology (FCT), Portugal Universidade do Porto Faculdade de Medicina, Portugal
1996/11/01 - 1998/02/28 Basic Science Researcher (FCT) Universidade do Porto Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2018/10/31 - 2019/03/14 HEALTHYAGING 2020
CENTRO-01-0145-FEDER-000012
Bolseiro de Pós-Doutoramento
2015/10/01 - 2018 Targeting hypothalamic sirtuin 2 to prevent metabolic disease
SFRH/BPD/111815/2015
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/03/01 - 2008/10 AGE-RELATED OXIDATIVE STRESS AND PROTEIN INTERACTIONS IN RENAL PROXIMAL TUBULAR CELLS OF RODENT MODELS OF HYPERTENSION
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBPD2%F346532%F2007/PT
 Fundação para a Ciência e a Tecnologia
Concluído
2006/01/01 - 2006/12/31 Molecular basis of aging in yeast
SFRH/BPD/13969/2003
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2004/01/01 - 2005/12/31 Characterization of signaling pathways in heart hypertrophy during pregnancy
SFRH/BPD/13969/2003
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
1998/03/01 - 2002/02/28 Regulation of sodium transepithelial flux and intracellular pH by monoamines and immediate precursors
PRAXIS XXI/BD/13364/97
Bolseiro de Doutoramento
Universidade do Porto Faculdade de Medicina, Portugal
Concluído

Projeto

Designação Financiadores
2018/03/15 - Atual FRUITIFY – Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes
PTDC/SAU-NUT/31712/2017
PTDC/SAU-NUT/31712/2017
Investigador
Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
N/A
Em curso
2017 - 2020/11 MobFood – Mobilização de conhecimento científico e tecnológico em resposta aos desafios do mercado agroalimentar
POCI-01-0247-FEDER-024524
POCI-01-0247-FEDER-024524
Investigador
N/A
Em curso
2018 - 2019/03/15 NiNjA - New Neuroendocrine Strategy for healthy Aging
POCI-01-0145-FEDER-0301
POCI-01-0145-FEDER-0301
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2015/07/01 - 2015/09/30 Projecto Mais Centro - New strategies to manage brain diseases
CENTRO-07-ST24-FEDER-002002
CENTRO-07-ST24-FEDER-002002
Bolseiro de Cientista Convidado
N/A
Concluído
2013 - 2015 Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics
CENTRO-07-ST24-FEDER-002006
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído
2013 - 2015 RES4MED: aprender medicina através da investigação
EXPL/IVC-PEC/1302/2013
EXPL/IVC-PEC/1302/2013
Investigador
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/01/01 - 2014 REGULATORY EFFECTS OF PATTERN RECOGNITION RECEPTORS (PRRS) IN ELECTROLYTE TRANSPORT AND MEMBRANE POTENTIAL IN INTESTINAL EPITHELIAL CELLS
info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F781942%F2011/PT
Investigador
Universidade do Porto Faculdade de Medicina, Portugal

INSERM U769, França
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2009/01/02 - 2011 Oxidative stress and genetic markers of cardiovascular risk in hypertension
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/83204/PT
Investigador
Universidade do Porto Faculdade de Medicina, Portugal

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2003/08/01 - 2005 Renal tubular vectorial sodium transport and regulatory mechanisms
info:eu-repo/grantAgreement/FCT/POCI/45767/PT
Investigador
Universidade do Porto Faculdade de Medicina, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
2000/09/01 - 2002 Dopamine and sodium handling in immortalised renal tubular epithelial cells from Spontaneous Hypertensive Rats (SHR) and Wistar Kyoto (WKY) rats
info:eu-repo/grantAgreement/FCT/POCI/35747/PT
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. da Silva Lima, Natália; Fondevila, Marcos F.; Nóvoa, Eva; Buqué, Xabier; Mercado-Gómez, Maria; Gallet, Sarah; González-Rellan, Maria J.; et al. "Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function". Journal of Hepatology (2021): http://dx.doi.org/10.1016/j.jhep.2021.09.008.
    Aceite para publicação • 10.1016/j.jhep.2021.09.008
  2. Nunes, Sara; Vieira, Pedro; Gomes, Pedro; Viana, Sofia Domingues; Reis, Flávio. "Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes Progression". Antioxidants 10 8 (2021): 1162. http://dx.doi.org/10.3390/antiox10081162.
    Publicado • 10.3390/antiox10081162
  3. Inês Preguiça; André Alves; Sara Nunes; Rosa Fernandes; Pedro Gomes; Sofia D. Viana; Flávio Reis. "Diet-induced rodent models of obesity-related metabolic disorders—A guide to a translational perspective". Obesity Reviews (2020): https://doi.org/10.1111/obr.13081.
    10.1111/obr.13081
  4. Carla S. S. Teixeira; Nuno M. F. S. A. Cerqueira; Pedro Gomes; Sérgio F. Sousa. "A Molecular Perspective on Sirtuin Activity". International Journal of Molecular Sciences 21 22 (2020): 8609-8609. https://doi.org/10.3390/ijms21228609.
    10.3390/ijms21228609
  5. Inês Preguiça; André Alves; Sara Nunes; Pedro Gomes; Rosa Fernandes; Sofia D. Viana; Flávio Reis. "Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy". Nutrients 12 1 (2020): 250-250. https://doi.org/10.3390/nu12010250.
    10.3390/nu12010250
  6. Gomes, Pedro; Viana, Sofia D.; Nunes, Sara; Rolo, Anabela P.; Palmeira, Carlos M.; Reis, Flávio. "The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders". Ageing Research Reviews 57 (2020): 100983. http://dx.doi.org/10.1016/j.arr.2019.100983.
    Publicado • 10.1016/j.arr.2019.100983
  7. Gomes, Pedro; Leal, Helena; Mendes, Alexandrina F.; Reis, Flávio; Cavadas, Cláudia. "Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases". Trends in Pharmacological Sciences 40 12 (2019): 1021-1039. http://dx.doi.org/10.1016/j.tips.2019.09.003.
    Publicado • 10.1016/j.tips.2019.09.003
  8. Lemos, Vera; de Oliveira, Rita M; Naia, Luana; Szegö, Éva; Ramos, Elisabete; Pinho, Sónia; Magro, Fernando; et al. "The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes". Human Molecular Genetics 26 21 (2017): 4105-4117. http://dx.doi.org/10.1093/hmg/ddx298.
    10.1093/hmg/ddx298
  9. Castela, Angela; Gomes, Pedro; Silvestre, Ricardo; Guardão, Luísa; Leite, Liliana; Chilro, Rui; Rodrigues, Ilda; et al. "Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?". Journal of Cellular Biochemistry 118 1 (2016): 82-91. http://dx.doi.org/10.1002/jcb.25613.
    Publicado • 10.1002/jcb.25613
  10. Gomes, António. "Ingestion of a natural mineral-rich water in an animal model of metabolic syndrome: effects in insulin signalling and endoplasmic reticulum stress". (2016):
    10.1515/hmbci-2015-0033
  11. Gomes, Pedro (5514-887A-7FDC); Outeiro, Tiago; Cavadas, Claudia. "Emerging role of Sirtuin 2 in the regulation of mammalian metabolism". Trends in Pharmacological Sciences 36 11 (2015): 756-768.
    Publicado • 10.1016/j.tips.2015.08.001
  12. Gomes, António. "Role of oxidative stress-induced systemic and cavernosal molecular alterations in the progression of diabetic erectile dysfunction". Journal of Diabetes (2015): http://onlinelibrary.wiley.com/doi/10.1111/1753-0407.12181/abstract.
    10.1111/1753-0407.12181
  13. Gomes, António. "Xanthohumol modulates inflammation, oxidative stress and angiogenesis in type 1 diabetic rat skin wound healing". Journal of Natural Products (2013): http://pubs.acs.org/doi/abs/10.1021/np4002898.
    10.1021/np4002898
  14. Gomes, António. "Identification of SLC26A transporters involved in the Cl-/HCO3 - exchange in proximal tubular cells from WKY and SHR". Life Sciences (2013):
    10.1016/j.lfs.2013.07.026
  15. Pedro Gomes. "Loss of oxidative stress tolerance in hypertension is linked to reduced catalase activity and increased c-Jun NH2-terminal kinase activation". Free Radical Biology & Medicine (2013): http://www.sciencedirect.com/science/article/pii/S0891584912018266.
    http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.017
  16. Pedro Gomes. "Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: a comparison with SHR.". Experimental Gerontology (2012): http://www.ncbi.nlm.nih.gov/pubmed/22687288.
    http://dx.doi.org/10.1016/j.exger.2012.05.022
  17. Castela, Â.; Soares, R.; Rocha, F.; Medeiros, R.; Ribeiro, R.; Monteiro, C.; Gomes, P.; et al. "Differentially expressed angiogenic genes in diabetic erectile tissue - Results from a microarray screening". Molecular Genetics and Metabolism 105 2 (2012): 255-262. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856080147&partnerID=MN8TOARS.
    10.1016/j.ymgme.2011.11.002
  18. Pedro Gomes. "H2O2 stimulates Cl-/HCO3- exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells.". Journal of Cellular Biochemistry (2011): http://www.ncbi.nlm.nih.gov/pubmed/21815192.
    10.1002/jcb.23299
  19. Pinto, V.; Amaral, J.; Silva, E.; Simão, S.; Cabral, J.M.; Afonso, J.; Serrão, M.P.; et al. "Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats". Mechanisms of Ageing and Development 132 6-7 (2011): 298-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961207610&partnerID=MN8TOARS.
    10.1016/j.mad.2011.06.003
  20. Simão, S.; Gomes, P.; Pinto, V.; Silva, E.; Amaral, J.S.; Igreja, B.; Afonso, J.; et al. "Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats". Experimental Gerontology 46 6 (2011): 468-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955647610&partnerID=MN8TOARS.
    10.1016/j.exger.2011.02.003
  21. Simão, S.; Gomes, P.; Jose, P.A.; Soares-da-Silva, P.. "Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3 - exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR". Biochemical Pharmacology 80 6 (2010): 913-919. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954762034&partnerID=MN8TOARS.
    10.1016/j.bcp.2010.05.013
  22. Silva, E.; Pinto, V.; Simão, S.; Serrão, M.P.; Afonso, J.; Amaral, J.; Pinho, M.J.; Gomes, P.; Soares-da-Silva, P.. "Renal aging in WKY rats: Changes in Na+,K+-ATPase function and oxidative stress". Experimental Gerontology 45 12 (2010): 977-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-78449298646&partnerID=MN8TOARS.
    10.1016/j.exger.2010.09.012
  23. Gomes, P.; Simão, S.; Silva, E.; Pinto, V.; Amaral, J.S.; Afonso, J.; Serrão, M.P.; Pinho, M.J.; Soares-Da-Silva, P.. "Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure". Oxidative Medicine and Cellular Longevity 2 3 (2009): 138-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349719148&partnerID=MN8TOARS.
  24. Gomes, P.; Saito, T.; del Corsso, C.; Alioua, A.; Eghbali, M.; Toro, L.; Stefani, E.. "Identification of a functional interaction between Kv4.3 channels and c-Src tyrosine kinase". Biochimica et Biophysica Acta - Molecular Cell Research 1783 10 (2008): 1884-1892. http://www.scopus.com/inward/record.url?eid=2-s2.0-50849106697&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.06.011
  25. Gomes, António. "Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span". Mechanisms of Ageing and Development (2007):
    10.1016/j.mad.2007.04.003
  26. Gomes, António. "Increases in transepithelial vectorial Na+ transport facilitates Na+-dependent L-DOPA transport in renal OK cells". Life Sciences (2006):
    10.1016/j.lfs.2006.02.018
  27. Gomes, António. "Overexpression of Na+/K+-ATPase Parallels the Increase in Sodium Transport and Potassium Recycling in an In Vitro Model of Proximal Tubule Cellular Ageing". The Journal of Membrane Biology (2006):
    10.1007/s00232-005-7017-5
  28. Gomes, António. "Upregulation of apical NHE3 in renal OK cells overexpressing the rodent alpha1-subunit of the Na pump". American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (2005):
    10.1152/ajpregu.00102.2005
  29. Gomes, António. "Gia3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event". American Journal of Physiology - Renal Physiology (2004):
    10.1152/ajprenal.00139.2004
  30. Gomes, António. "Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells". British Journal of Pharmacology (2004):
    10.1038/sj.bjp.0705893
  31. Gomes, António. "Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells". Kidney International (2004):
    10.1111/j.1523-1755.2004.00722.x
  32. Gomes, António. "Dopamine acutely decreases type 3 Na+/H+ exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades". European Journal of Pharmacology (2004):
    10.1016/j.ejphar.2004.02.011
  33. Gomes, António. "Distinct Signalling Cascades Downstream to Gsa Coupled Dopamine D1-like NHE3 Inhibition in Rat and Opossum Renal Epithelial Cells". Cellular Physiology and Biochemistry (2004):
    10.1159/000076930
  34. Gomes, António. "Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells". British Journal of Pharmacology (2003):
    10.1038/sj.bjp.0705125
  35. Gomes, António. "Organ-Specific Overexpression of Renal LAT2 and Enhanced Tubular L-DOPA Uptake Precede the Onset of Hypertension". Hypertension (2003):
    10.1161/01.HYP.0000091822.00166.B1
  36. Gomes, António. "Transport of the organic cations gonyautoxin 2/3 epimers, a paralytic shellfish poison toxin, through the human and rat intestinal epitheliums". Toxicon (2002):
    10.1016/S0041-0101(02)00118-6
  37. Gomes, António. "Expression and function of sodium transporters in two opossum kidney cell clonal sublines". American Journal of Physiology - Renal Physiology (2002):
    10.1152/ajprenal.00340.2001
  38. Gomes, António. "D2-like receptor-mediated inhibition of Na-K-ATPase activity is dependent on the opening of K+ channels". American Journal of Physiology - Renal Physiology (2002):
    10.1152/ajprenal.00244.2001
  39. Gomes, António. "Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na+-K+-ATPase activity". American Journal of Physiology - Renal Physiology (2002):
    10.1152/ajprenal.00318.2001
  40. Gomes, António. "Dopamine-induced inhibition of Na+-K+-ATPase activity requires integrity of actin cytoskeleton in opossum kidney cells". Acta Physiologica Scandinavica (2002):
    10.1046/j.1365-201X.2002.00972.x
  41. Gomes, António. "Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines". The Journal of Membrane Biology (2002):
    10.1007/s00232-001-0136-8
  42. Gomes, António. "Na+/H+ exchanger activity and dopamine D1-like receptor function in two opossum kidney cell clonal sublines". Cellular Physiology and Biochemistry (2002):
    10.1159/000067896
  43. Gomes, António. "Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na+/H+exchanger". American Journal of Physiology - Regulatory, Integrative and Comparative Physiology (2001):
    10.1152/ajpregu.2001.281.1.R10
  44. Gomes, António. "D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors". Kidney International (2001):
    10.1046/j.1523-1755.2001.0590051683.x
  45. Gomes, António. "Interaction between l-DOPA and 3-O-methyl-l-DOPA for transport in immortalised rat capillary cerebral endothelial cells". Neuropharmacology (1999):
    10.1016/S0028-3908(99)00042-8
  46. Gomes, António. "L-DOPA transport properties in an immortalised cell line of rat capillary cerebral endothelial cells, RBE 4". Brain Research (1999):
    10.1016/S0006-8993(99)01387-6
  47. Gomes, António. "L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan share the same transporter in Opossum kidney cells". The International Journal of Biochemistry & Cell Biology (1998):
    10.1016/S1357-2725(97)00115-5
  48. Gomes, António. "Competitive and non-competitive inhibition of L-3,4-dihydroxyphenylalanine uptake in Opossum kidney cells". European Journal of Pharmacology (1997):
    10.1016/S0014-2999(97)01083-2
  49. Gomes, António. "Opossum kidney cells take up L-DOPA through an organic cation potential-dependent and proton-independent transporter". Cell Biology International (1997):
    10.1006/cbir.1997.0142
  50. Gomes, António. "Renal and intestinal autocrine monoaminergic systems: dopamine versus 5- hydroxytryptamine". Clinical and Experimental Hypertension (1997):
    10.3109/10641969709080803
Capítulo de livro
  1. Sousa, Teresa; Reina-Couto, Marta; Gomes, Pedro. "Role of Oxidative Stress in the Pathophysiology of Arterial Hypertension and Heart Failure". In Oxidative Stress in Heart Diseases, 509-537. Springer Singapore, 2019.
    Publicado • 10.1007/978-981-13-8273-4_23
  2. Gomes, Pedro. "SIRT2". In Encyclopedia of Signaling Molecules, 1-8. Springer New York, 2016.
    10.1007/978-1-4614-6438-9_101725-1
  3. Gomes, Pedro; Soares-da-silva, Patrício. "Dopamine". In Cardiovascular Hormone Systems, editado por Michael Bader, 251-293. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
    Publicado • 10.1002/9783527626236.ch11
Tese / Dissertação
  1. Gomes, Pedro. "Regulation of sodium transepithelial flux and intracellular pH by monoamines and immediate precursors". Doutoramento, Universidade do Porto Faculdade de Medicina, 2002.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/02 Development of in vitro approaches to evaluate hypothalamic insulin signaling in metabolic dysfunctions L Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2020/01 Sirtuin 2 – emerging roles in metabolic regulation Invited Seminar
University of Cambridge (Cambridge, Reino Unido)
2019/05 As sirtuinas como mediadores das respostas metabólicas à disponibilidade de nutrientes: implicações patofisiológicas XVIII Congresso Internacional de Nutrição e Alimentação da Associação Portuguesa de Nutrição (APN)
(Porto, Portugal)
2019/02 Sirtuin 2 deficiency triggers hepatic lipid accumulation through ER stress-dependent pathway XLIX Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
2019/01 Novel insights into the role of Sirtuin 2 in metabolic regulation Invited seminar
University of the Basque Country (UPV/EHU) (Bilbao, Espanha)
2018/10 Targeting Sirtuin 2 to improve metabolic dysfunction Invited Seminar
Center for Neuroscience and Cell Biology (CNC) (Coimbra, Portugal)
2018/07 Unraveling a role for the NAD+-dependent deacetylase Sirtuin 2 in metabolic regulation Invited Seminar
University of Santiago de Compostela (Santiago de Compostela, Espanha)
2018/05 Sirtuin 2: an emerging target in peripheral and central insulin resistance Invited Seminar
Coimbra Institute for Clinical Biomedical Research (ICBR) (Coimbra, Portugal)
2018/02 A role for sirtuin 2 in the regulation of hepatic lipid metabolism XLVIII Meeting of the Portuguese Society of Pharmacology
(Lisboa, Portugal)
2018/02 Role of mammalian sirtuins in metabolic and inflammatory disorders Invited Seminar
German Institute of Human Nutrition (DIfE), University of Potsdam (Berlin, Alemanha)
2018/02 Introduction to methodologies to monitor oxidative stress Invited Seminar
German Institute of Human Nutrition (DIfE), University of Potsdam (Berlin, Alemanha)
2017/12 New insights into the role of sirtuin 2 in metabolic regulation Invited Seminar
Encontros científicos do CEDOC (Chronic Diseases Research Center), Universidade Nova de Lisboa (Lisboa, Portugal)
2017/10 Sirtuin 2 deficiency promotes exacerbated adiposity and hepatic lipid accumulation in mice subjected to diet-induced obesity 9º Simpósio de Metabolismo FMUP
(Porto, Portugal)
2017/02 Sirtuin 2 deficiency worsens insulin resistance and adiposity of mice subjected to diet-induced obesity XLVII Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2016/02 Modulation of insulin sensitivity by hypothalamic sirtuin 2 XLVI Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
2015/04 Sirtuin 2: a novel regulator of insulin sensitivity Invited Seminar
Center for Neuroscience and Cell Biology (CNC) (Coimbra, Portugal)
2014/02 Sirtuin 2 reverses hepatic insulin resistance by attenuating ROS generation and mitochondrial dysfunction XLIV Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2013/06 Protein deacetylase sirtuin 2 regulates mitochondrial function in human liver HepG2 cells 23th Scientific Meeting of the European Society of Hypertension
(Milão, Itália)
2013/06 The NAD-dependent deacetylase sirtuin 2 improves insulin sensitivity through a ROS-mediated mechanism 23th Scientific Meeting of the European Society of Hypertension
(Milão, Itália)
2013/03 The emerging therapeutic potential of sirtuins in age-related diseases Invited Seminar
Seminários FMUP (Faculdade de Medicina da Universidade do Porto) (Porto, Portugal)
2012/12 Increased expression of oxidative stress markers in human diabetic cavernosal tissue – comparison with clinical data 15th Congress of the European Society for Sexual Medicine
(Amesterdão, Países Baixos)
2012/04 Sirtuinas: Envelhecimento, Metabolismo e Doença Invited Seminar
Semana de Ciências da Nutrição da Associação de Estudantes da Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto (Porto, Portugal)
2012/04 Downregulation of the age-related protein sirtuin 2 in liver of type 2 diabetic mice 22nd Scientific Meeting of the European Society of Hypertension
(Londres, Reino Unido)
2011/12 Protein structural alterations in diabetic cavernosal tissue – their role in erectile dysfunction progression 14th Congress of the European Society for Sexual Medicine
(Milão, Itália)
2011/11 Erectile dysfunction associated to diabetes – differential expression of angiogenic genes evaluated by microarrays XXXVII Brazilian Congress of Urology
(Florianópolis, Brasil)
2011/11 Molecular alterations induced by oxidative stress in cavernosal tissue – relevance in the progression of diabetic erectile dysfunction XXXVII Brazilian Congress of Urology
(Florianópolis, Brasil)
2011/10 Sirtuin 2 and insulin resistance: is there a connection? 3º Simpósio de Metabolismo FMUP
(Porto, Portugal)
2011/06 Expressão diferencial de genes angiogénicos em tecido eréctil diabético – resultados de uma análise por microarrays Annual Meeting Portuguese Association of Urology
(Ofir, Portugal)
2010/11 Oxidative stress-induced molecular alterations in diabetic erectile tissue 13th Congress of the European Society for Sexual Medicine
(Málaga, Espanha)
2008/12 Effect of apocynin on blood pressure and oxidative stress parameters in young WKY and SHR rats British Pharmacological Society Winter Meeting
(Brighton, Reino Unido)
2008/06 Resistance of immortalized renal cells from WKY and SHR rats to oxidative stress is associated with activation of multiple MAPK signaling pathways 18th Scientific Meeting of the European Society of Hypertension
(Berlim, Alemanha)
2003/09 Dopamine acutely decreases Na+/H+ exchanger NHE3 activity in renal OK cells through the activation of protein kinase A and C signaling cascades 11th Meeting on Adrenergic Mechanisms
(Porto, Portugal)
2002/09 Regulation of sodium transepithelial flux and intracellular pH by monoamines and immediate precursors Invited Seminar
University of Stanford (Palo Alto, Estados Unidos)
2002/09 Regulation of sodium transepithelial flux and intracellular pH by monoamines and immediate precursors Invited Seminar
University of California at San Diego (San Diego, Estados Unidos)
2001/12 D1-like receptors stimulate PLC activity in OK cells independent of Gq/11 activation British Pharmacological Society
(Londres, Reino Unido)
2001/08 Transporters of L-DOPA in two clonal OK cell lines function as exchangers with neutral and basic amino acids 7th International Congress on Amino Acid and Proteins
(Viena, Áustria)
2001/02 Expression and function of sodium transporters in two opossum kidney cell clonal sublines XXXII Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2000/12 Decreases in Na+ transepithelial flux by dopamine is primarily dependent on inhibition of the apical Na+/H+ exchanger British Pharmacological Society
(Birmingham, Reino Unido)
2000/09 Gi protein coupled D2-like receptors stimulate K+ channels through a cAMP-independent pathway in OK cells 10th Meeting on Adrenergic Mechanisms
(Porto, Portugal)
2000/02 Sequential activation of PKA/PKC signaling pathways during D1–mediated inhibition of renal Na+-K+ATPase XXXI Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
2000/02 Decreases in Na+ transepithelial flux by dopamine is primarily dependent on inhibition of the apical Na+/H+ exchanger XXXI Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)
1999/12 Transepithelial flux of sodium and handling of L-DOPA in renal epithelial cells XXX Meeting of the Portuguese Society of Pharmacology
(Lisboa, Portugal)
1999/12 Dopamine inhibits Na+,K+-ATPase activity through stimulation of both D1 and D2 receptor by cAMP-dependent and cAMP-independent pathways XXX Meeting of the Portuguese Society of Pharmacology
(Lisboa, Portugal)
1999/04 Apical L-DOPA-Na+ cotransport and intracellular pH in OK cells Joint Meeting of the British and Portuguese Pharmacological Societies
(Porto, Portugal)
1998/12 Characteristics of L-DOPA and L-5-HTP transport in RBE 4 cells, an immortalised cell line of rat capillary cerebral endothelial cells XXIX Meeting of the Portuguese Society of Pharmacology
(Estoril, Portugal)
1997/10 Sodium, pH and handling of L-DOPA in renal epithelial cells Joint Meeting of the Nordic and Portuguese Pharmacological Societies
(Vilamoura, Portugal)
1997/10 Competitive and non-competitive inhibitors of L-DOPA uptake in OK cells Joint Meeting of the Nordic and Portuguese Pharmacological Societies
(Vilamoura, Portugal)
1996/12 Immediate precursors of natriuretic dopamine and antinatriuretic 5-HT share the same uptake transporters in renal OK cells XXVI Meeting of the Portuguese Society of Pharmacology
(Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2017 - Atual Sirtuin 2 as a new target to revert metabolic dysfunction
Coorientador de Helena Maria da Silva Leal
 Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 - 2018/07/26 Exploring the role of sirtuin in lipid homeostasis
Orientador de João Miguel Esteves Correia da Silva Cardoso
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 - 2018/04/24 LRH-1 signaling and control of liver intermediary metabolism: impact on nonalcoholic fatty liver disease
Coorientador
 Biologia Básica e Aplicada (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2017/09/11 Insights into the role of sirtuin 2 in obesity and insulin resistance
Orientador
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2016/07/18 Unraveling the role of SIRT2 in Metabolic Homeostasis
Orientador de Marta Correia Quatorze
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2015/07/23 Anatomical distribution and regulation of hypothalamic sirtuin 2 in response to energy availability
Orientador de Liliana Isabel Fernandes Santos
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011 - 2012/06/01 Efeitos neuroprotetores das sirtuinas: potencial intervenção terapêutica em doenças neurodegenerativas
Orientador de Ana Sequeira
 Mestrado Integrado em Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2011/11/18 Modulação in vivo da angiogénese, inflamação e stresse oxidativo em situações fisiopatológicas após consumo de cerveja enriquecida em xanto-humol
Coorientador
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2016/09/30 - 2016/09/30 1st Symposium on Aging Research @CNC – Molecular Mechanisms of Aging and Age-Related Diseases. Center for Neuroscience and Cell Biology, University of Coimbra, Portugal (2016/09/30 - 2016/09/30)
Simpósio (Membro da Comissão Organizadora)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019/07/16 The effect of dietary polyphenols upon the intestinal absorption of fructose: relevance for metabolic syndrome
Arguente principal
 Nelson Vinicius Melo Andrade (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018/09/18 iPSCs-derived NESCs for neuroregeneration in MJD
Arguente principal
 Daniel Alexandre Sousa Henriques (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09/17 Fetal Liver Mitochondria Alterations in an Ovine Model of Maternal Obesity
Arguente principal
 Inês Maria Nogueira Cardoso (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07/26 Exploring the role of Sirtuin 2 in lipid homeostasis
Orientador
 João Miguel Esteves Correia Silva Cardoso (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/12/11 Modulation of the carotid body activity to treat obesity
Arguente principal
 Miguel Correia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/11/11 Insights into the role of sirtuin 2 in obesity and insulin resistance
Orientador
 Patrícia Marques Diogo Valério (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/09/12 AAV-Based Tools for the Development of Cellular and Animal Models of Machado-Joseph Disease
Arguente principal
 Miguel Monteiro Lopes (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/03/06 Role of hypoxia and fibrosis in adipose tissue
Vogal
 Ana Patrícia Barreira Marques (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02/17 Delaying neurodegeneration through caloric restriction approaches: From mechanisms to molecular therapy
Vogal
 Janete Antónia da Cunha Santos (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09/09 Repeated systemic transplantation of mesnchymal stromal cells: a therapeutic strategy for Machado-Joseph disease?
Arguente principal
 Adriana Isabel Vale Marcelo (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/08 The role of sirtuin 2 in oligodendroglia on dopaminergic neuron differentiation and regeneration
Arguente principal
 Ana Rita Abrantes Dias (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/09/08 RNAi silencing of Machado-Joseph disease using AAV9: intracranial injection versus intravenous injection
Arguente principal
 Clelia Fusco (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/18 Unraveling the role of Sirtuin 2 in metabolic homeostasis
Orientador
 Marta Correia Quatorze (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/07/23 Sirtuin 2 in hypothalamus: an emerging target in insulin resistance?
Orientador
 Liliana Isabel Fernandes Santos (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/06/01 Efeitos neuroprotetores das sirtuinas: potencial intervenção terapêutica em doenças neurodegenerativas
Orientador
 Ana Catarina Ramos Sequeira (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2012 - Atual Ad Hoc reviewer for numerous scientific journals, including: Aging (Albany NY), British Journal of Pharmacology, Cellular Physiology and Biochemistry, Current Aging Science, Diabetes, FEBS Letters, Frontiers in Molecular Neuroscience, Frontiers in Neurology, Journal of Cellular Physiology, Life Sciences, Oxidative Medicine and Cellular Longevity, The FASEB Journal, among others

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019/11/20 - Atual Consultancy on the compound selisistat (a potent and selective inhibitor of protein sirtuin 1) and possible therapeutic applications. AOP Orphan Pharmaceuticals AG, Áustria

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Portuguese Society of Sciences in Laboratory Animals (SPCAL) Full member
2000 - Atual Portuguese Society of Pharmacology Full member
Distinções

Prémio

2002 Prémio Gulbenkian (Ciências e Tecnologias Aplicadas)
Fundação Calouste Gulbenkian, Portugal

Outra distinção

2017 Innovate Competition award (iMed Conference 9.0)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 Best poster award (9º Simpósio Metabolismo)
Universidade do Porto Faculdade de Medicina, Portugal
2011 1st Prize Post-Graduate Oncology & Molecular Biology 2011 (6th Young European Scientist Meeting)
Universidade do Porto Faculdade de Medicina, Portugal
2010 JABA RECORDATI Urologia
Associação Portuguesa de Urologia, Portugal