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Helena Tomás graduated in Chemical Engineering/Biotechnology (IST, Lisbon, Portugal) and has a Ph.D. degree in Technological Chemistry/Biomaterials (1996, University of Lisbon, Portugal). Currently, she is an Associate Professor at the University of Madeira (Portugal) and Senior Researcher in the Materials Research Group at CQM-Centro de Química da Madeira. At UMa, among other responsibilities, she was Head of the Chemistry Department for several periods (2000-2003, 2019-2021, 2022-2025), President of the Pedagogical Board (1999-2001), and Director of the master program in Applied Biochemistry (2010-2019). Her teaching activity has been mainly focused on the Biochemistry and Biomaterials areas. Her research work stands out for its multidisciplinary approach, combining chemistry, materials science, and biotechnology to create impactful solutions with potential applications in regenerative medicine, and cancer (namely, targeted nanomaterials for cancer therapy). She has been mainly devoted to the development of nanogels and dendrimer-based and clay-based nanomaterials (drug/gene delivery and theranostics). She was principal investigator/participant in several research projects funded by FCT, INTERREG MAC, INTERREG Atlantic Area, ProCiência 2020, Horizon Europe, as well as Chinese institutions. At CQM, she was the main supervisor of 5 post-doc researchers, 5 PhD students (2 still ongoing), and 10 master students (she also co-supervised 4 post-doc researchers, 7 PhD students, and 12 master students). She belonged to the management committee of the COST action TD0802: Dendrimers in Biomedical Applications (2010-2013), as well as the COST action CA17140: NANO2CLINIC-Cancer nanomedicine - from the bench to the bedside (2018-2023, where she was a member of the proponent group). She authored/co-authored 85 papers in peer-reviewed journals, and 4 book chapters (WoS h-index= 39, total citations> 5700). She has 21 publications with more than 80 citations and one of her publications was cited > 1100 times. She was part of the Stanford University and Elsevier Worlds Top 2% Scientists list in 2022 and 2023. Throughout her entire career, she has consistently devoted a considerable amount of her time to promoting science among both younger audiences and the general public. In this regard, it is noteworthy to mention: a) She was a member of the National Commission for the celebration of the Year of the Periodic Table (2019) and promoted/organized various activities on the topic throughout the island of Madeira. b) She was responsible for organizing the event «A QUÍMICA É DIVERTIDA» («Chemistry in Fun», a regular science dissemination event involving fun experiments, colloquia, competitions, etc.) at CQM/UMa (2006-2019). c) She organized the participation of CQM in the nationwide initiative promoted by the «Ciência Viva» agency, offering research internships for high school students during the summer (2007-2019). d) She organized, in 2007, the CQM participation in a set of 3 television science programs for «Panda Channel» which is a TV channel dedicated to children. e) She was responsible (partner leader) for Madeira's participation in the European project Future2020: How will life be in 2020? Call: FP7-PEOPLE-2013-NIGHT, project 609809 (European Researchers' Night 2013). During this event, among other activities, she organized a TV debate with Madeira local TV (RTP Madeira). f) She presented numerous science lessons in secondary schools on the island of Madeira.
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Identificação

Identificação pessoal

Nome completo
Helena Maria Pires Gaspar Tomás

Nomes de citação

  • Tomás, Helena
  • Tomás, H.
  • H. Tomás

Identificadores de autor

Ciência ID
4D14-D31E-A8BE
ORCID iD
0000-0002-7856-2041
Google Scholar ID
https://scholar.google.com.br/citations?user=gMkTUB8AAAAJ&hl=pt-BR
Researcher Id
E-5991-2010
Scopus Author Id
6508104177

Endereços de correio eletrónico

  • lenat@staff.uma.pt (Profissional)
  • lenat@uma.pt (Profissional)

Moradas

  • Universidade da Madeira. CQM-Centro de Química da Madeira, Faculdade de Ciências Exactas e Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105, Funchal, S. Pedro, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B1) Utilizador proficiente (C1)
Português (Idioma materno)
Formação
Grau Classificação
1996
Concluído
 TECHNOLOGICAL CHEMISTRY - BIOMATERIALS (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Avaliação do comportamento à corrosão e da citocompatibilidade de uma liga ortopédica de Co-Cr-Mo" (TESE/DISSERTAÇÃO)
 Aproved with distinction
1989
Concluído
 CHEMICAL ENGINEERING - BIOTECHNOLOGY (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2004/01/01 - Atual Investigador principal (carreira) (Investigação) Universidade da Madeira Centro de Química da Madeira, Portugal
Universidade da Madeira Centro de Química da Madeira, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2002/02/22 - Atual Professor Associado (Docente Universitário) Universidade da Madeira, Portugal
1996/05/28 - 2002/02/03 Professor Auxiliar (Docente Universitário) Universidade da Madeira, Portugal
1995/10/13 - 1996/05/27 Assistente Estagiário (Docente Universitário) Universidade da Madeira, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/12/21 - 2025/04/10 Coordinator of the Chemistry Department Universidade da Madeira, Portugal
Universidade da Madeira, Portugal
2019/02/08 - 2021/03/10 Coordinator of the Chemistry Department Universidade da Madeira, Portugal
2009/04/01 - 2021/01/30 Diretor of the Materials Research Group at CQM Universidade da Madeira Centro de Química da Madeira, Portugal
2017/06/27 - 2019/10/17 Head of the Pedagogic Council of the Faculty of Exact Sciences and Engineering Universidade da Madeira, Portugal
2010/04/15 - 2019/10/17 Director of the Master in Applied Biochemistry Universidade da Madeira, Portugal
2000/07/04 - 2003/11/19 Coordinator of the Chemistry Department Universidade da Madeira, Portugal
1999/03/03 - 2001/03/21 Presidente do Conselho Pedagógico Universidade da Madeira, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1990/10/01 - 1995/09/30 Ph.D. student (Ph.D. grant from JNICT) Universidade de Lisboa Faculdade de Ciências, Portugal
Projetos

Projeto

Designação Financiadores
2025/09/01 - Atual FOCUS-4R - Fostering Outermost regions Capabilities in Research and Innovation and Upgrading Skills complying with 4R principles
101217074
Investigador
European Commission
Em curso
2020 - 2023 Inv2Mac- Potencial aprovechamiento de biomasa generada a partir de especies vegetales invasoras de la Macaronesia para uso industrial
MAC2/4.6d/229
Investigador
European Regional Development Fund
2020 - 2023 Construction of Functional Dendrimer-Based Nanogels For Ultrasound-Enhanced Tumor Theranostics
-
Investigador
Science and Technology Commission of Shanghai Municipality
2018/01/01 - 2021/06/30 BLUEHUMAN (partner leader) - BLUE biotechnology as a road for innovation on HUMAN's health aiming smart growth in Atlantic Area
EAPA 151/2016
Investigador
European Regional Development Fund
Concluído
2016/07/01 - 2020/03/31 BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke
PTDC/CTM-NAN/3547/2014
Investigador
Universidade da Madeira, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017 - 2019 MARINEBLUEREFINE-Valorização do potencial insular para aplicações de valor acrescentado
M1420-01-0247-FEDER-000006
Investigador
European Regional Development Fund
Concluído
2017 - 2019 ECOFIBRAS - Valorización ecosostenible de especies vegetales invasoras de la Macaronesia para la obtención de fibras de uso industrial
MAC/4.6d/040
Investigador
European Regional Development Fund
2013/04/03 - 2015/08/02 DENDIMAGE - Development of Novel Dendrimer-Based Nanoparticles for Dual Mode Computed Tomography and Magnetic Resonance Imaging of Tumors
PTDC/CTM-NAN/1748/2012
Investigador
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015/02/28 Self-assembled nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery
PTDC/CTM-NAN/116788/2010
Investigador
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/04/01 - 2014/09/30 DENDRIMAT - New materials for drug/gene delivery based on the self-assembly of dendrimer-chitosan-single stranded DNA
PTDC/CTM-NAN/112428/2009
Investigador responsável
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2012 - 2014 Dendrimer-based multifunctional hybrid nanoparticles as probes for dual-mode targeted tumor diagnosis
12520705500
Investigador
Science and Technology Commission of Shanghai Municipality
Concluído
2009 - 2013 VinSaudeMAC – Evaluation of the biological effects of red wines on the prevention of atherosclerotic, oncologic and neurologic diseases
MAC/1/M105
Investigador
European Regional Development Fund
2011 - 2012 Assembly of carbon nanotubes onto the surface of electrospun nanofibers for stem cell differentiation applications
11BA1400500
Investigador
Foundation - Shanghai Baiyulan Foundation
2007/09/01 - 2010/12/31 DENDRALGENE - Design of new gene delivery vectors based on dendrimers, alginate and the RGD sequence for bone tissue engineering
PTDC/SAU-BEB/71161/2006
Investigador responsável
Universidade da Madeira, Portugal

Universidade da Madeira Centro de Química da Madeira, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2001/01/01 - 2005/12/31 Three-dimensional systems of collagen type I, proteoglycans and growth factors for bone cell proliferation and differentiation
POCTI/ESP/33620/99
Investigador responsável
Universidade da Madeira Centro de Química da Madeira, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Rita Castro; Pedro L. Granja; João Rodrigues; Ana Paula Pêgo; Helena Tomás. "Bioinspired hybrid DNA/dendrimer-based films with supramolecular chirality". Journal of Materials Chemistry B (2025): https://doi.org/10.1039/D4TB02761B.
    10.1039/D4TB02761B
  2. Waad El Mejri; Ayoub El Mahdi; Fátima Mendes; Rita Castro; Leila Njim; Sonia Zaied; Helena Tomás; et al. "Chitosan films synthesized via thiol-ene click chemistry: Toward safe and versatile platforms for packaging, cosmetics and biomedical applications". Sustainable Chemistry and Pharmacy 40 (2024): 101643. https://doi.org/10.1016/j.scp.2024.101643.
    Acesso aberto • 10.1016/j.scp.2024.101643
  3. Ye Tian; Zhiqiang Wang; Xu Xu; Yunqi Guo; Yanni Ma; Yanqi Lu; Mingwu Shen; et al. "Natural alkaloids from Dicranostigma leptopodum (Maxim.) Fedde and their G5. NHAc-PBA dendrimer-alkaloid complexes for targeting chemotherapy in breast cancer MCF-7 cells". Natural Product Research (2024): 1-18. https://doi.org/10.1080/14786419.2024.2335669.
    Acesso aberto • 10.1080/14786419.2024.2335669
  4. Jinkai Zhang; Yu Zhuang; Ruilong Sheng; Helena Tomás; João Rodrigues; Guangyin Yuan; Xudong Wang; Kaili Lin. "Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics". Materials Horizons (2024): http://dx.doi.org/10.1039/d3mh01260c.
    10.1039/d3mh01260c
  5. Jinxia Wang; Zhiqiang Wang; Guixiang Zhang; João Rodrigues; Helena Tomás; Xiangyang Shi; Mingwu Shen. "Blood–brain barrier-crossing dendrimers for glioma theranostics". Biomaterials Science (2024): https://doi.org/10.1039/D4BM00043A.
    10.1039/D4BM00043A
  6. Martins, Ivo J; Tomás, Helena; Rodrigues, João. "Carbon dots and dendrimers nanohybrids: from synthesis to applications". Materials Today Chemistry 32 101662 (2023): https://doi.org/10.1016/j.mtchem.2023.101662.
    Publicado
  7. Cláudia Camacho; Dina Maciel; Helena Tomás; João Rodrigues. "Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Study". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15020689.
    10.3390/pharmaceutics15020689
  8. Zeyu Fu; Yu Zhuang; Jinjie Cui; Ruilong Sheng; Helena Tomás; João Rodrigues; Bin Zhao; Xudong Wang; Kaili Lin. "Development and challenges of cells- and materials-based tooth regeneration". Engineered Regeneration (2022): http://dx.doi.org/10.1016/j.engreg.2022.04.003.
    10.1016/j.engreg.2022.04.003
  9. Zhe Wang; Yili Zhao; Mingwu Shen; Helena Tomás; Benqing Zhou; Xiangyang Shi. "Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers". Journal of Functional Biomaterials 13 2 (2022): 55-55. https://doi.org/10.3390/jfb13020055.
    10.3390/jfb13020055
  10. Mignani, Serge; Shi, Xiangyang; Rodrigues, Joao; Tomas, Helena; Majoral, Jean-Pierre. "Dendrimer nanoplatforms for veterinary medicine applications: A concise overview". Drug Discovery Today (2022): https://publons.com/wos-op/publon/50095335/.
    10.1016/J.DRUDIS.2022.01.001
  11. Dina Maciel; Nádia Nunes; Francisco Santos; Yu Fan; Gaoming Li; Mingwu Shen; Helena Tomás; Xiangyang Shi; João Rodrigues. "New insights into ruthenium(ii) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviour". Journal of Materials Chemistry B (2022): https://doi.org/10.1039/D2TB01280D.
    10.1039/D2TB01280D
  12. Gonçalves, Mara; Kairys, Visvaldas; Rodrigues, João; Tomás, Helena. "Polyester Dendrimers Based on Bis-MPA for Doxorubicin Delivery". Biomacromolecules 23 1 (2021): 20-33. http://dx.doi.org/10.1021/acs.biomac.1c00455.
    10.1021/acs.biomac.1c00455
  13. dos Santos, Flavia Suzany Ferreira; Vieira, Mariana; da Silva, Henrique Nunes; Tomás, Helena; Fook, Marcus Vinícius Lia. "Surface Bioactivation of Polyether Ether Ketone (PEEK) by Sulfuric Acid and Piranha Solution: Influence of the Modification Route in Capacity for Inducing Cell Growth". Biomolecules 11 9 (2021): 1260. http://dx.doi.org/10.3390/biom11091260.
    10.3390/biom11091260
  14. Silva, Catarina Luís; Perestrelo, Rosa; Capelinha, Filipa; Tomás, Helena; Câmara, José S.. "An integrative approach based on GC-qMS and NMR metabolomics data as a comprehensive strategy to search potential breast cancer biomarkers". Metabolomics 17 8 (2021): http://dx.doi.org/10.1007/s11306-021-01823-1.
    Publicado • 10.1007/s11306-021-01823-1
  15. Serge Mignani; Xangyang Shi; João Rodrigues; Helena Tomas; Andrii Karpus; Jean-Pierre Majoral. "First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward". European Journal of Medicinal Chemistry 219 (2021): 113456-113456. https://doi.org/10.1016/j.ejmech.2021.113456.
    10.1016/j.ejmech.2021.113456
  16. Ivo Martins; Helena Tomás; Fernando Lahoz; João Rodrigues. "Engineered Fluorescent Carbon Dots and G4-G6 PAMAM Dendrimer Nanohybrids for Bioimaging and Gene Delivery". Biomacromolecules 22 6 (2021): 2436-2450. https://doi.org/10.1021/acs.biomac.1c00232.
    10.1021/acs.biomac.1c00232
  17. Cláudia Camacho; Helena Tomás; João Rodrigues. "Use of Half-Generation PAMAM Dendrimers (G0.5–G3.5) with Carboxylate End-Groups to Improve the DACHPtCl2 and 5-FU Efficacy as Anticancer Drugs". Molecules 26 10 (2021): 2924-2924. https://doi.org/10.3390/molecules26102924.
    10.3390/molecules26102924
  18. Mignani, Serge; Shi, Xiangyang; Ceña, Valentin; Rodrigues, João; Tomas, Helena; Majoral, Jean-Pierre. "Engineered non-invasive functionalized dendrimer/dendron-entrapped/complexed gold nanoparticles as a novel class of theranostic (radio)pharmaceuticals in cancer therapy". Journal of Controlled Release 332 (2021): 346-366. http://dx.doi.org/10.1016/j.jconrel.2021.03.003.
    10.1016/j.jconrel.2021.03.003
  19. Wang. Zhao; Olim, Filipe; Sun, Jingjing; Neves, Ana Rute; Mendes, Fátima; Tomás, Helena; Sheng, Ruilong. "Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy". Medicine Research 5 2000231 (2021): http://www.medicineresearch.org/EN/10.21127/yaoyimr20200023.
  20. Su, Xiqi; Wang, Le; Xie, JingHua; Liu, XiaoHui; Tomás, Helena. "Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances". Current Organic Chemistry 25 2 (2021): 301-314. http://dx.doi.org/10.2174/1385272824999201001154127.
    10.2174/1385272824999201001154127
  21. Evdokimova, Olga L.; Alves, Carla S.; Krsmanovic Whiffen, Radenka M.; Ortega, Zaida; Tomas, Helena; Rodrigues, Joao. "Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulose". Journal of Zhejiang University SCIENCE B (2021): https://publons.com/wos-op/publon/34006995/.
    10.1631/JZUS.B2000683
  22. Olim, Filipe; Neves, Ana Rute; Vieira, Mariana; Tomas, Helena; Sheng, Ruilong. "Self-Assembly of Cholesterol-Doxorubicin and TPGS into Prodrug-Based Nanoparticles with Enhanced Cellular Uptake and Lysosome-Dependent Pathway in Breast Cancer Cells". European Journal of Lipid Science and Technology (2021): https://publons.com/wos-op/publon/43322537/.
    10.1002/EJLT.202000337
  23. Zeng, Yujun; Xiang, Yufan; Sheng, Ruilong; Tomas, Helena; Rodrigues, Joao; Gu, Zhongwei; Zhang, Hu; Gong, Qiyong; Luo, Kui. "Polysaccharide-based nanomedicines for cancer immunotherapy: A review". Bioactive Materials (2021): https://publons.com/wos-op/publon/36413638/.
    10.1016/J.BIOACTMAT.2021.03.008
  24. Hugo Yves C. Eulálio; Mariana Vieira; Thiago B. Fideles; Helena Tomás; Suédina M. L. Silva; Carlos A. Peniche; Marcus Vinícius L. Fook. "Physicochemical Properties and Cell Viability of Shrimp Chitosan Films as Affected by Film Casting Solvents. I-Potential Use as Wound Dressing". Materials (2020): https://doi.org/10.3390/ma13215005.
    10.3390/ma13215005
  25. Zhang, Xiaoqin; Wu, Yahui; Li, Zhiqian; Wang, Wenjia; Wu, Yaping; Pan, Dayi; Gu, Zhongwei; et al. "Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy". Carbohydrate Polymers 247 (2020): 116749. http://dx.doi.org/10.1016/j.carbpol.2020.116749.
    10.1016/j.carbpol.2020.116749
  26. Yu Zou; Du Li; Yue Wang; Zhijun Ouyang; Yucheng Peng; Helena Tomás; Jindong Xia; et al. "Polyethylenimine Nanogels Incorporated with Ultrasmall Iron Oxide Nanoparticles and Doxorubicin for MR Imaging-Guided Chemotherapy of Tumors". Bioconjugate Chemistry (2020): https://doi.org/10.1021/acs.bioconjchem.0c00036.
    10.1021/acs.bioconjchem.0c00036
  27. Mara Gonçalves; Serge Mignani; João Rodrigues; Helena Tomás. "A glance over doxorubicin based-nanotherapeutics: From proof-of-concept studies to solutions in the market". Journal of Controlled Release 317 (2020): 347-374. https://doi.org/10.1016/j.jconrel.2019.11.016.
    10.1016/j.jconrel.2019.11.016
  28. Cláudia S. Camacho; Marta Urgellés; Helena Tomás; Fernando Lahoz; João Rodrigues. "New insights into the blue intrinsic fluorescence of oxidized PAMAM dendrimers considering their use as bionanomaterials". Journal of Materials Chemistry B (2020): https://doi.org/10.1039/D0TB01871F.
    10.1039/D0TB01871F
  29. Tomás, Helena. "Untargeted Urinary 1H NMR-Based Metabolomic Pattern as a Potential Platform in Breast Cancer Detection". Metabolites (2019): http://dx.doi.org/10.3390/metabo9110269.
    10.3390/metabo9110269
  30. Tomás, H.. "Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis". Acta Biomaterialia (2019): http://dx.doi.org/10.1016/j.actbio.2019.09.005.
    10.1016/j.actbio.2019.09.005
  31. Maciel D; Guerrero-Beltrán C; Ceña-Diez R; Tomás H; Muñoz-Fernández MÁ; Rodrigues J; Dina Maciel; et al. "New anionic poly(alkylideneamine) dendrimers as microbicide agents against HIV-1 infection.". Nanoscale (2019): http://europepmc.org/abstract/med/31066407.
    10.1039/c9nr00303g
  32. Silva C; Perestrelo R; Silva P; Tomás H; Câmara JS. "Breast Cancer Metabolomics: From Analytical Platforms to Multivariate Data Analysis. A Review.". Metabolites (2019): http://europepmc.org/abstract/med/31121909.
    10.3390/metabo9050102
  33. Silva C; Perestrelo R; Silva P; Capelinha F; Tomás H; Câmara JS; Catarina Silva; et al. "Volatomic pattern of breast cancer and cancer-free tissues as a powerful strategy to identify potential biomarkers.". The Analyst (2019): http://europepmc.org/abstract/med/31144689.
    10.1039/c9an00263d
  34. Silva CL; Perestrelo R; Silva P; Tomás H; Câmara JS. "Implementing a central composite design for the optimization of solid phase microextraction to establish the urinary volatomic expression: a first approach for breast cancer.". Metabolomics : Official journal of the Metabolomic Society (2019): http://europepmc.org/abstract/med/30997581.
    10.1007/s11306-019-1525-2
  35. Spinola, Vitor; Pinto, Joana; Llorent-Martinez, Eulogio J.; Tomas, Helena; Castilho, Paula C.. "Evaluation of Rubus grandifolius L. (wild blackberries) activities targeting management of type-2 diabetes and obesity using in vitro models". Food and Chemical Toxicology 123 (2019): 443-452. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000456754300038&KeyUID=WOS:000456754300038.
    10.1016/j.fct.2018.11.006
  36. Aijun Li; Yu Fan; Xueyan Cao; Liang Chen; Le Wang; Carla S. Alves; Serge Mignani; et al. "Morpholino-functionalized phosphorus dendrimers for precision regenerative medicine: osteogenic differentiation of mesenchymal stem cells". Nanoscale (2019): https://doi.org/10.1039/C9NR06410A.
    10.1039/C9NR06410A
  37. Wang, Zhao; Neves, Ana Rute; Olim, Filipe; Tomás, Helena; Tang, Shi; Sheng, Ruilong. "Green polymers toward nanobiotechnology(I): synthesis of glycopolypeptides and their analogues". (2019): http://hdl.handle.net/10400.13/2847.
    10.21127/yaoyigc20190010
  38. Jingyi Zhu; Guoying Wang; Carla S. Alves; Helena Tomás; Zhijuan Xiong; Mingwu Shen; João Rodrigues; Xiangyang Shi. "Multifunctional Dendrimer-Entrapped Gold Nanoparticles Conjugated with Doxorubicin for pH-Responsive Drug Delivery and Targeted Computed Tomography Imaging". Langmuir (2018): https://doi.org/10.1021/acs.langmuir.8b02901.
    10.1021/acs.langmuir.8b02901
  39. Mignani, Serge; Rodrigues, Joao; Tomas, Helena; Caminade, Anne-Marie; Laurent, Regis; Shi, Xiangyang; Majoral, Jean-Pierre. "Recent therapeutic applications of the theranostic principle with dendrimers in oncology". Science China-Materials 61 11 (2018): 1367-1386. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000450217400002&KeyUID=WOS:000450217400002.
    10.1007/s40843-018-9244-5
  40. Mignani, Serge; Rodrigues, Joao; Tomas, Helena; Jalal, Rachid; Singh, Parvinder Pal; Majoral, Jean-Pierre; Vishwakarma, Ram A.. "Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?". Drug Discovery Today 23 3 (2018): 605-615. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428490100014&KeyUID=WOS:000428490100014.
    10.1016/j.drudis.2018.01.010
  41. Serge Mignani; João Rodrigues; Helena Tomas; Maria Zablocka; Xiangyang Shi; Anne-Marie Caminade; Jean-Pierre Majoral. "Dendrimers in combination with natural products and analogues as anti-cancer agents". Chemical Society Reviews (2018): https://doi.org/10.1039/C7CS00550D.
    10.1039/C7CS00550D
  42. Tomas, Helena; Alves, Carla S.; Rodrigues, Joao. "Laponite (R) : A key nanoplatform for biomedical applications?". Nanomedicine-Nanotechnology Biology and Medicine 14 7 (2018): 2407-2420. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000446496900040&KeyUID=WOS:000446496900040.
    10.1016/j.nano.2017.04.016
  43. Gouveia, Marisol; Figueira, Joao; Jardim, Manuel G.; Castro, Rita; Tomas, Helena; Rissanen, Kari; Rodrigues, Joao. "Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(eta(5)-C5H5)(PPh3)(2)](+) as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cells". Molecules 23 6 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000435875400232&KeyUID=WOS:000435875400232.
    10.3390/molecules23061471
  44. Santos, Sofia D.; Xavier, Miguel; Leite, Diana M.; Moreira, Debora A.; Custodio, Beatriz; Torrado, Marilia; Castro, Rita; et al. "PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia". Journal of Controlled Release 291 (2018): 65-79. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000450099100005&KeyUID=WOS:000450099100005.
    10.1016/j.jconrel.2018.10.006
  45. Mignani, Serge; Rodrigues, Joao; Tomas, Helena; Roy, Rene; Shi, Xiangyang; Majoral, Jean-Pierre. "Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis". Advanced Drug Delivery Reviews 136 (2018): 73-81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000454380900006&KeyUID=WOS:000454380900006.
    10.1016/j.addr.2017.11.007
  46. Silva, Catarina L.; Perestrelo, Rosa; Silva, Pedro; Tomas, Helena; Camara, Jose S.. "Volatile metabolomic signature of human breast cancer cell lines". Scientific Reports 7 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000396172300001&KeyUID=WOS:000396172300001.
    10.1038/srep43969
  47. Tomás, Helena. "Compound high-quality criteria: a new vision to guide the development of drugs, current situation". Drug Discovery Today (2016):
    10.1016/j.drudis.2016.01.005
  48. Mignani, Serge; Huber, Scot; Tomas, Helena; Rodrigues, Joao; Majoral, Jean-Pierre. "Why and how have drug discovery strategies in pharma changed? What are the new mindsets?". Drug Discovery Today 21 2 (2016): 239-249. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000371367400007&KeyUID=WOS:000371367400007.
    10.1016/j.drudis.2015.09.007
  49. Singh, Anil K.; Bhardwaj, Jitender K.; Olival, Ana; Kumar, Yogesh; Podder, Avijit; Maheshwari, Ankur; Agrawal, Renuka; et al. "Design, synthesis and biological evaluation of Arylpiperazine-based novel Phthalimides: Active inducers of testicular germ cell apoptosis". Journal of Chemical Sciences 128 8 (2016): 1245-1263. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000381206800007&KeyUID=WOS:000381206800007.
    10.1007/s12039-016-1122-0
  50. Xiao, Shili; Castro, Rita; Maciel, Dina; Goncalves, Mara; Shi, Xiangyang; Rodrigues, Joao; Tomas, Helena. "Fine tuning of the pH-sensitivity of laponite-doxorubicin nanohybrids by polyelectrolyte multilayer coating". Materials Science & Engineering C-Materials For Biological Applications 60 (2016): 348-356. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000369204700041&KeyUID=WOS:000369204700041.
    10.1016/j.msec.2015.11.051
  51. Kirthiga Ramalingam; Rita Castro; Pedro Pires; Xiangyang Shi; João Rodrigues; Shili Xiao; Helena Tomás. "Gene delivery using dendrimer/pDNA complexes immobilized in electrospun fibers using the Layer-by-Layer technique". RSC Advances 6 99 (2016): 97116-97128. https://doi.org/10.1039/C6RA22444J.
    10.1039/C6RA22444J
  52. Zhan, Yuan; Goncalves, Mara; Yi, Panpan; Capelo, Debora; Zhang, Yuhong; Rodrigues, Joao; Liu, Changsheng; et al. "Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery". Journal of Materials Chemistry B 3 20 (2015): 4221-4230. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354450300012&KeyUID=WOS:000354450300012.
    10.1039/c5tb00468c
  53. Leiro, Victoria; Garcia, Joao Pedro; Tomas, Helena; Pego, Ana Paula. "The Present and the Future of Degradable Dendrimers and Derivatives in Theranostics". Bioconjugate Chemistry 26 7 (2015): 1182-1197. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358186500005&KeyUID=WOS:000358186500005.
    10.1021/bc5006224
  54. He, Xuedan; Alves, Carla S.; Oliveira, Nilsa; Rodrigues, Joao; Zhu, Jingyi; Banyai, Istvan; Tomas, Helena; Shi, Xiangyang. "RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells". Colloids and Surfaces B-Biointerfaces 125 (2015): 82-89. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348951400011&KeyUID=WOS:000348951400011.
    10.1016/j.colsurfb.2014.11.004
  55. Kong, Lingdan; Alves, Carla S; Hou, Wenxiu; Qiu, Jieru; Mohwald, Helmuth; Tomas, Helena; Shi, Xiangyang. "RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells.". ACS applied materials & interfaces 7 8 (2015): 4833-43. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25658033&KeyUID=MEDLINE:25658033.
    10.1021/am508760w
  56. Xiao, Shili; Castro, Rita; Rodrigues, Joao; Shi, Xiangyang; Tomas, Helena. "PAMAM Dendrimer/pDNA Functionalized-Magnetic Iron Oxide Nanoparticles for Gene Delivery". Journal of Biomedical Nanotechnology 11 8 (2015): 1370-1384. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351892100006&KeyUID=WOS:000351892100006.
    10.1166/jbn.2015.2101
  57. Li, Yulin; Maciel, Dina; Rodrigues, Joao; Shi, Xiangyang; Tomas, Helena. "Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery". Chemical Reviews 115 16 (2015): 8564-8608. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360321300009&KeyUID=WOS:000360321300009.
    10.1021/cr500131f
  58. Wang, Zhe; Zhao, Yili; Luo, Yu; Wang, Shige; Shen, Mingwu; Tomás, Helena; Zhu, Meifang; Shi, Xiangyang. "Attapulgite-doped electrospun poly(lactic-co-glycolic acid) nanofibers enable enhanced osteogenic differentiation of human mesenchymal stem cells". RSC Advances 5 4 (2015): 2383-2391. http://dx.doi.org/10.1039/c4ra09839k.
    10.1039/c4ra09839k
  59. Wang, Guoying; Maciel, Dina; Wu, Yilun; Rodrigues, Joao; Shi, Xiangyang; Yuan, Yuan; Liu, Changsheng; Tomas, Helena; Li, Yulin. "Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery". Acs Applied Materials & Interfaces 6 19 (2014): 16687-16695.
    10.1021/am5032874
  60. Goncalves, Mara; Maciel, Dina; Capelo, Debora; Xiao, Shili; Sun, Wenjie; Shi, Xiangyang; Rodrigues, Joao; Tomas, Helena; Li, Yulin. "Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging". Biomacromolecules 15 2 (2014): 492-499.
    10.1021/bm401400r
  61. Liao, Huihui; Liu, Hui; Li, Yulin; Zhang, Mengen; Tomas, Helena; Shen, Mingwu; Shi, Xiangyang. "Antitumor Efficacy of Doxorubicin Encapsulated Within PEGylated Poly( amidoamine) Dendrimers". Journal of Applied Polymer Science 131 11 (2014):
    10.1002/app.40358
  62. Luo, Y.; Wang, S.; Shen, M.; Qi, R.; Fang, Y.; Guo, R.; Cai, H.; et al. "Carbon nanotube-incorporated multilayered cellulose acetate nanofibers for tissue engineering applications". Carbohydrate Polymers 91 1 (2013): 419-427. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865823065&partnerID=MN8TOARS.
    10.1016/j.carbpol.2012.08.069
  63. Gonçalves, M.; Figueira, P.; Maciel, D.; Rodrigues, J.; Shi, X.; Tomás, H.; Li, Y.. "Antitumor Efficacy of Doxorubicin-Loaded Laponite/Alginate Hybrid Hydrogels". Macromolecular Bioscience (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84882357133&partnerID=MN8TOARS.
    10.1002/mabi.201300241
  64. Maciel, D.; Figueira, P.; Xiao, S.; Hu, D.; Shi, X.; Rodrigues, J.; Tomás, H.; Li, Y.. "Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity". Biomacromolecules 14 9 (2013): 3140-3146. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883762311&partnerID=MN8TOARS.
    10.1021/bm400768m
  65. Gonçalves, M.; Figueira, P.; Maciel, D.; Rodrigues, J.; Qu, X.; Liu, C.; Tomás, H.; Li, Y.. "pH-sensitive Laponite®/doxorubicin/alginate nanohybrids with improved anticancer efficacy". Acta Biomaterialia (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885492252&partnerID=MN8TOARS.
    10.1016/j.actbio.2013.09.013
  66. Wang, Shige; Tomas, Helena; Shi, Xiangyang; Wang, S.; Castro, R.; An, X.; Song, C.; et al. "Electrospun laponite-doped poly(lactic-co-glycolic acid) nanofibers for osteogenic differentiation of human mesenchymal stem cells". Journal of Controlled Release 172 1 (2013): E139-E139. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000336961900238&KeyUID=WOS:000336961900238.
    10.1016/j.jconrel.2013.08.224
  67. Nouri, A.; Castro, R.; Kairys, V.; Santos, J.L.; Rodrigues, J.; Li, Y.; Tomás, H.. "Insight into the role of N,N-dimethylaminoethyl methacrylate (DMAEMA) conjugation onto poly(ethylenimine): Cell viability and gene transfection studies". Journal of Materials Science: Materials in Medicine 23 12 (2012): 2967-2980. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871434184&partnerID=MN8TOARS.
    10.1007/s10856-012-4753-9
  68. Li, Y.; Rodrigues, J.; Tomás, H.. "Injectable and biodegradable hydrogels: Gelation, biodegradation and biomedical applications". Chemical Society Reviews 41 6 (2012): 2193-2221. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863229467&partnerID=MN8TOARS.
    10.1039/c1cs15203c
  69. Shan, Y.; Luo, T.; Peng, C.; Sheng, R.; Cao, A.; Cao, X.; Shen, M.; et al. "Gene delivery using dendrimer-entrapped gold nanoparticles as nonviral vectors". Biomaterials 33 10 (2012): 3025-3035. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856275170&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2011.12.045
  70. Santos, J.L.; Nouri, A.; Fernandes, T.; Rodrigues, J.; Tomás, H.. "Gene delivery using biodegradable polyelectrolyte microcapsules prepared through the layer-by-layer technique". Biotechnology Progress 28 4 (2012): 1088-1094. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864859566&partnerID=MN8TOARS.
    10.1002/btpr.1576
  71. Nouri, A.; Castro, R.; Santos, J.L.; Fernandes, C.; Rodrigues, J.; Tomás, H.. "Calcium phosphate-mediated gene delivery using simulated body fluid (SBF)". International Journal of Pharmaceutics 434 1-2 (2012): 199-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864153035&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2012.05.066
  72. Goncalves, M.; Castro, R.; Rodrigues, J.; Tomas, H.; Gonçalves, M.; Tomás, H.. "The Effect of PAMAM Dendrimers on Mesenchymal Stem Cell Viability and Differentiation". Current Medicinal Chemistry 19 29 (2012): 4969-4975. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000309976900008&KeyUID=WOS:000309976900008.
    10.2174/0929867311209024969
  73. Rodrigues, J.; Jardim, M.G.; Figueira, J.; Gouveia, M.; Tomás, H.; Rissanen, K.. "Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers". New Journal of Chemistry 35 10 (2011): 1938-1943. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053361429&partnerID=MN8TOARS.
    10.1039/c1nj20364a
  74. Pandita, D.; Santos, J.L.; Rodrigues, J.; Pêgo, A.P.; Granja, P.L.; Tomás, H.. "Gene delivery into mesenchymal stem cells: A biomimetic approach using rgd nanoclusters based on poly(amidoamine) dendrimers". Biomacromolecules 12 2 (2011): 472-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951658350&partnerID=MN8TOARS.
    10.1021/bm1012647
  75. Santos, J.L.; Pandita, D.; Rodrigues, J.; Pêgo, A.P.; Granja, P.L.; Tomás, H.. "Non-viral gene delivery to mesenchymal stem cells: Methods, strategies and application in bone tissue engineering and regeneration". Current Gene Therapy 11 1 (2011): 46-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951686783&partnerID=MN8TOARS.
    10.2174/156652311794520102
  76. Li, Y.; MacIel, D.; Tomás, H.; Rodrigues, J.; Ma, H.; Shi, X.. "PH sensitive Laponite/alginate hybrid hydrogels: Swelling behaviour and release mechanism". Soft Matter 7 13 (2011): 6231-6238. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959495125&partnerID=MN8TOARS.
    10.1039/c1sm05345k
  77. Santos, J.L.; Oliveira, H.; Pandita, D.; Rodrigues, J.; Pêgo, A.P.; Granja, P.L.; Tomás, H.. "Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells". Journal of Controlled Release 144 1 (2010): 55-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953239685&partnerID=MN8TOARS.
    10.1016/j.jconrel.2010.01.034
  78. Santos, J.L.; Pandita, D.; Rodrigues, J.; Pêgo, A.P.; Granja, P.L.; Balian, G.; Tomás, H.. "Receptor-mediated gene delivery using PAMAM dendrimers conjugated with peptides recognized by mesenchymal stem cells". Molecular Pharmaceutics 7 3 (2010): 763-774. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953253240&partnerID=MN8TOARS.
    10.1021/mp9002877
  79. Santos, J.L.; Oramas, E.; Pêgo, A.P.; Granja, P.L.; Tomás, H.. "Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors". Journal of Controlled Release 134 2 (2009): 141-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-60649096454&partnerID=MN8TOARS.
    10.1016/j.jconrel.2008.11.007
  80. Alves, N.M.; Shi, J.; Oramas, E.; Santos, J.L.; Tomás, H.; Mano, J.F.. "Bioinspired superhydrophobic poly(L-lactic acid) surfaces control bone marrow derived cells adhesion and proliferation". Journal of Biomedical Materials Research - Part A 91 2 (2009): 480-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349464694&partnerID=MN8TOARS.
    10.1002/jbm.a.32210
  81. Fernandes, L.F.; Costa, M.A.; Fernandes, M.H.; Tomás, H.. "Osteoblastic behavior of human bone marrow cells cultured over adsorbed collagen layer, over surface of collagen gels, and inside collagen gels". Connective Tissue Research 50 5 (2009): 336-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350754598&partnerID=MN8TOARS.
    10.3109/03008200902855909
  82. Nascimento, M.L.; Mueller, W.D.; Carvalho, A.C.; Tomás, H.M.; Mueller, W.-D.; Tomás, H.. "Electrochemical characterization of titanium biomaterials using the Mini-cell System". Journal of Materials Science 41 11 (2006): 3323-3327. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745697952&partnerID=MN8TOARS.
    10.1007/s10853-005-5426-6
  83. Sedláková, P.; Svobodová, J.; Mikšík, I.; Tomás, H.. "Separation of poly(amidoamine) (PAMAM) dendrimer generations by dynamic coating capillary electrophoresis". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 841 1-2 (2006): 135-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747788046&partnerID=MN8TOARS.
    10.1016/j.jchromb.2006.03.013
  84. Caldeira Araújo, H.; Smit, W.; Verhoeven, N.M.; Salomons, G.S.; Silva, S.; Vasconcelos, R.; Tomás, H.; et al. "Guanidinoacetate methyltransferase deficiency identified in adults and a child with mental retardation". American Journal of Medical Genetics 133 A 2 (2005): 122-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-20044386883&partnerID=MN8TOARS.
    10.1002/ajmg.a.30226
  85. TOMAS, H; CARVALHO, GS; FERNANDES, MH; FREIRE, AP; ABRANTES, LM; Tomás, H.. "The use of rat, rabbit or human bone marrow derived cells for cytocompatibility evaluation of metallic elements". Journal of Materials Science-Materials in Medicine 8 4 (1997): 233-238. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997WU94500008&KeyUID=WOS:A1997WU94500008.
    10.1023/A:1018543808210
  86. Tomás, H.; Carvalho, G.S.; Fernandes, M.H.; Freire, A.P.; Abrantes, L.M.. "Effects of Co-Cr corrosion products and corresponding separate metal ions on human osteoblast-like cell cultures". Journal of Materials Science: Materials in Medicine 7 5 (1996): 291-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030150670&partnerID=MN8TOARS.
    10.1007/BF00058569
  87. Tomas, H.; Friere, A.P.; Abrantes, L.M.. "Cast Co-Cr alloy and pure chromium in proteinaceous media: An electrochemical characterization". Journal of Materials Science: Materials in Medicine 5 6-7 (1994): 446-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028445287&partnerID=MN8TOARS.
    10.1007/BF00058981
Artigo em revista (magazine)
  1. Tomás, Helena. "A Química é divertida, Doze anos de promoção da Química na Madeira, Química (Boletim da Sociedade Portuguesa de Química), nº104, p.51-52 (2007).", 2007
Capítulo de livro
  1. Tomás, Helena; Rodrigues, João. Autor correspondente: Rodrigues, João. "Dendrimers and dendrimer-based nano-objects for oncology applications". In New Trends in Smart Nanostructured Biomaterials in Health Sciences, 41-78. Elsevier, 2023.
    Publicado • 10.1016/b978-0-323-85671-3.00002-6
  2. Tomás, H.; A. P. Pêgo; R. Castro; P. Moreno. "Nucleic acid delivery mediated by polysaccharide-based vectors". editado por M.H. Gil. Research Signpost/Transworld Research Network, 2014.
    Publicado
  3. TOMAS, H; FREIRE, AP; ABRANTES, LM; KOSSOWSKY, R; KOSSOVSKY, N. "Activity of plasma proteins regarding biomaterials corrosion - pH Effects". 1995.
Poster em conferência
  1. Mendes, Fátima; del Olmo, Natalia Sanz; Garcia, Jorge San Jacinto; Malkoch, Michael; Tomás, Helena. "Development of polyester-based dendritic structures loaded with cisplatin for targeted treatment of osteosarcoma". Trabalho apresentado em Molecules4Life - I International Meeting 2023, 2023.
  2. dos Orfaos, Lydia; Tomás, Helena; Rodrigues, João. "Fluorination of G4 PAMAM dendrimers for gene delivery". Trabalho apresentado em 31st Conference of the European Society for Biomaterials - ESB2021, 2021.
  3. Gonçalves, Mara; João Manuel Cunha Rodrigues; Li, Yulin; Tomás, Helena. "Amine partially functionalized polyester dendrimers for doxorubicin delivery". Trabalho apresentado em FIRST COST ACTION CA17140 Conference, 2019.
  4. Mendes, Fátima; Olim, Filipe; Neves, Ana Rute; Rodrigues, João; Tomás, Helena. "Laponite®-based nanogels for the treatment of osteoporosis.". Trabalho apresentado em XXVI Encontro Nacional da SPQ ¿ XXVIENSPQ., 2019.
  5. dos Orfaos, Lydia; Rodrigues, João; Tomás, Helena. "Functionalization of generation four PAMAM dendrimers - the fluorination effect". Trabalho apresentado em XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
  6. dos Orfaos, Lydia; Camacho, Cláudia; Tomás, Helena; Rodrigues, João. "Fluorinated and Non-fluorinated Generation Four (G4) PAMAM dendrimers". Trabalho apresentado em 11th International Dendrimer Symposium, 2019.
  7. Alves, Carla S.; Antunes, Natacha; Tomás, Helena; Castanho, Miguel A.R.B.; Rodrigues, João Manuel Cunha. "Synthesis of Novel Surface Modified Dendrimers for Dengue and Zika Viral Entry Inhibition". Trabalho apresentado em 11th International Dendrimer Symposium, 2019.
  8. Abreu, Nilsa; Alves, Carla S.; Tomás, Helena; Shi, Xiangyang; Rodrigues, João Manuel Cunha. "Hyaluronic Acid-Modified Dendrimer Entrapped Gold Nanoparticles". Trabalho apresentado em 11th International Dendrimer Symposium, 2019.
  9. Santos, SD; Xavier, Miguel; Leite DM; Moreira, Débora; Custódio, Beatriz; Torrado M; Castro, R.; et al. "The transport of therapeutic molecules to the ischemic brain: dendrimers as carriers in pre-clinical studies". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  10. Gonçalves, Mara; João Manuel Cunha Rodrigues; Tomás, Helena. "Polyester dendrimers as delivery vehicles for doxorubicin". Trabalho apresentado em Madeira International Conference on Emerging Trends and Future of Nanomaterials for Human Health - MAD-NANO18, 2018.
  11. Mendes, Fátima; Olim, Filipe; Neves, Ana Rute; Rodrigues, João; Tomás, Helena. "Laponite-based Nanogels for Alendronate Delivery". Trabalho apresentado em MAD-NANO18: Madeira International Conference on Emerging Trends and Future of Nanomaterials for Human Health., 2018.
  12. Santos, SD; Xavier, Miguel; Leite, DM; Moreira, Débora; Custódio, Beatriz; Torrado M; Castro, R; et al. "Blood-Brain Barrier Transport and Neuronal Uptake of PAMAM Dendrimers after Focal Brain Ischemia". Trabalho apresentado em i3S annual meeting, 2018.
  13. Santos, SD; Xavier, Miguel; Leite DM; Moreira, Débora; Castro, R; Leiro, Victoria; Rodrigues, J.; Tomás, Helena; Pêgo, Ana. "Nanoparticle-mediated Blood-Brain Barrier Transport for Neuronal Delivery in Focal Brain Ischemia". Trabalho apresentado em 10th International Symposium on Neuroprotection and Neurorepair, 2018.
  14. Ideia, P.; Pinto, J.; Ferreira, R.; Figueiredo, L.; Tomás, H.; Castilho, P. C.. "Extraction and characterization of hydroxyapatite from Madeira Island fish transforming industry by-products.". Trabalho apresentado em 2nd BioMaH conference, 2018.
  15. Gonçalves, Mara; João Manuel Cunha Rodrigues; Tomás, Helena. "Doxorubicin-based systems with improved anti-cancer efficacy". Trabalho apresentado em Ciência 2018, 2018.
  16. Gonçalves, Mara; João Manuel Cunha Rodrigues; Tomás, Helena. "Poly(amidoamine) vs bis-MPA Dendrimers: A comparative Study for Doxorubicin Encapsulation". Trabalho apresentado em Gordon Research Center on Cancer Nanotechnology, 2017.
  17. Santos, S.D.; Leiro, V; Lopes, C.D.F.; Xavier M.A; Leite, D.; Tomás, H.; Pêgo, A.P.. "PEGylated PAMAM dendrimers can effectively reach the injured ischemic brain". Trabalho apresentado em 6th China-Europe Symposium on Biomaterials in Regenerative Medicine CESB2017. Porto, Portugal., 2017.
  18. Santos SD; Leiro, V; Lopes CDF; Xavier MA; Leite, D.; Tomás, H.; Pêgo, AP. "Blood-Brain Barrier Transport and Brain Uptake of Poly(Ethylene Glycol)-Modified PAMAM Dendrimers in brain ischemia". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience., Braga, Portugal, 2017.
  19. Gonçalves, Mara; Ana Cristina Dias Olival; João Manuel Cunha Rodrigues; Tomás, Helena. "Polyester Dendrimers for Dual Gene and Drug Delivery - Preliminary Results". Trabalho apresentado em Indo-Portuguese Workshop on Emerging Trends of Nanotechnology in Chemistry and Biology ¿ INCB-2016, 2016.
  20. Gonçalves, Mara; Maciel, Dina; Capelo, Débora; Xiao, Shili; Sun, Wenjie; Shi, Xiangyang; João Manuel Cunha Rodrigues; Tomás, Helena; Li, Yulin. "Poly(amidoamine) dendrimer-mediated nanogels for drug delivery and intracellular tracking". Trabalho apresentado em 1st International Conference on Emerging Trends of Nanotechnology in Drug Discovery - INDD-2014, 2014.
  21. Gonçalves, Mara; Maciel, Dina; Xiao, Shili; Shi, Xiangyang; João Manuel Cunha Rodrigues; Tomás, Helena. "Dendrimer-Assisted Formation Of Self-Fluorescent Nanogels For Simultaneous Drug Delivery and Intracellular Tracking Imaging". Trabalho apresentado em Chinese Medicinal Chemistry Symposium (CMCS), 2013.
  22. Maciel, Dina; Gonçalves, Mara; Alves, C. S.; Shi, Xiangyang; João Manuel Cunha Rodrigues; Tomás, Helena; Li, Yulin. "Triple Cell-Responsive Nanogels For Drug Delivery Into Cancer Cells". Trabalho apresentado em Chinese Pharmaceutical Conference, 2013.
  23. Castro, Rita; Santos, J.L.; Gonçalves, Mara; João Manuel Cunha Rodrigues; Tomás, Helena. "Fatty-acid Functionalized PAMAM Dendrimers for Gene Silencing". Trabalho apresentado em 8th International Dendrimer Symposium, 2013.
  24. Gonçalves, Mara; Castro, Rita; João Manuel Cunha Rodrigues; Tomás, Helena. "PAMAM Dendrimers do Not Affect Mesenchymal Stem Cells Differentiation". Trabalho apresentado em 8th International Dendrimer Symposium, 2013.
  25. Gonçalves, Mara; Castro, Rita; João Manuel Cunha Rodrigues; Tomás, Helena. "Effect of PAMAM Dendrimers with Different Surface Functionalities on Mesenchymal Stem Cells Differentiation". Trabalho apresentado em 7th International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, 2012.
  26. Santos JL; Oramas EG; Pêgo, Ana Paula; Granja PL; Tomás, H.. "Osteogenic differentiation of mesenchymal stem cells through gene delivery". Trabalho apresentado em 3rd International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy, ¿From Molecular Mechanisms to Therapeutical applications¿, 2008, Faro, Portugal,, 2008.
  27. Santos JL; Oramas EG; Pêgo, Ana Paula; Granja PL; Tomás, H.. "In vitro osteogenesis via gene delivery". Trabalho apresentado em 5th Marie Curie Cutting-Edge Conference, 2008,Funchal, Madeira, Portugal, 2008.
  28. Santos JL; Oliveira, H.; Oramas EG; Pêgo, Ana Paula; Granja PL; Tomás, H.. "Gene therapy platform for bone regeneration using dendrimers and osteogenic plasmids systems". Trabalho apresentado em Gordon Research Conference-Biomaterials: Biocompatability/Tissue Engineering, 2007, Holderness, NH, USA, 2007.
  29. Santos L.; Pêgo, Ana Paula; Granja PL; Tomás, H.. "In vitro evaluation of gene delivery in bone marrow stromal cells by polyamidoamine dendrimers". Trabalho apresentado em XIV Annual Congress of the European Society of Gene Delivery, 2006, Athens, Greece, 2006.
  30. Costa, Maria; Monteiro, E.; Trigo Cabral, A.; Tomás, H.; Fernandes, M.H.. "Three dimensional matrices support the growth of human bone marrow cells.". Trabalho apresentado em ESB 2002 ¿ 17th European Conference on Biomaterials, Barcelona, Espanha, 11-14 de Setembro de 2002., 2002.
Resumo em conferência
  1. Mendes, Fátima; del Olmo, Natalia Sanz; Garcia, Jorge San Jacinto; Malkoch, Michael; Tomás, Helena. "Polyester-based dendritic block copolymers with biodegradable properties for potential cancer treatment". Trabalho apresentado em 10th CQM Meeting, Funchal, 2023.
    Publicado
  2. Mendes, Fátima; del Olmo, Natalia Sanz; Garcia, Jorge San Jacinto; Malkoch, Michael; Tomás, Helena. "Synthesis of Cisplatin loaded Polyester-based dendritic structures for the targeted treatment of Osteosarcoma". Trabalho apresentado em 2nd CA17140 STSM Conference, 2023.
    Publicado
  3. Duarte, Ana; Tomás, Helena; Rodrigues, João. Autor correspondente: Rodrigues, João. "Development of Laponite® gels for cisplatin delivery". Trabalho apresentado em 10th CQM Annual Meeting, Funchal, 2023.
  4. dos Orfaos, Lydia; Rodrigues, João; Tomás, Helena. "Oxidation of fluorinated PAMAM dendrimer - A combination of fluorescence and NMR traceability". Trabalho apresentado em 9th CQM Annual Meeting, Funchal, 2022.
    Publicado
  5. Duarte, Ana; Olim, Filipe; Tomás, Helena. Autor correspondente: Olim, Filipe. "Fucoidan-based delivery system for cisplatin in glioblastoma cells". Trabalho apresentado em 9th CQM Annual Meeting, Funchal, 2022.
  6. Mendes, Fátima; Olim, Filipe; Neves, Ana Rute; Rodrigues, João; Tomás, Helena. "Bisphosphonates: a brief review and envisaged work towards osteosarcoma treatment". Trabalho apresentado em 8th CQM annual meeting, Funchal, 2021.
    Publicado
  7. Martins, Ivo; Pita, Filipa; Tomás, Helena; Rodrigues, João. Autor correspondente: Martins, Ivo. "Exploring new routes in the preparation of carbon dots for biomedical applications". Trabalho apresentado em 8th CQM Annual Meeting, Funchal, 2021.
  8. dos Orfaos, Lydia; Tomás, Helena; Rodrigues, João. "A fluorinated dendrimer for traceable gene delivery". Trabalho apresentado em 8th CQM Annual Meeting, Funchal, 2021.
    Publicado
  9. Martins, Ivo J; Tomás, Helena; Lahoz, Fernando; Rodrigues, João. "Nanohybrids and Hybridplexes based on Carbon Dots and PAMAM Dendrimer for Bioimaging and Gene Delivery". Trabalho apresentado em Encontro Nacional da Sociedade Portuguesa de Química, Braga, 2021.
  10. Maciel, D.; Nunes, N. ; Tomás, H.; Rodrigues, J.. Autor correspondente: Rodrigues, J.. "Ruthenium Metallodendrimers for Cancer Therapy: Contributions to the Field and Perspectives (Invited lecture)". Trabalho apresentado em Sino-French Innovative Nanomedicine Forum & Celebration of 80th Birthday of Professor Jean-Pierre Majoral, Shanghai, 2021.
  11. Mendes, Fátima; Olim, Filipe; Neves, Ana Rute; Vieira, Mariana; Rodrigues, João; Tomás, Helena. "Laponite®-based nanogels for bone tissue regeneration and treatment of osteoporosis". Trabalho apresentado em 7th CQM Annual Meeting, Funchal, 2020.
    Publicado
  12. dos Orfaos, Lydia; Tomás, Helena; Rodrigues, João. "The fluorination of poly(amidoamine) (PAMAMG4-NH2) dendrimers - synthesis characterization and biological studies". Trabalho apresentado em 7th CQM Annual Meeting, Funchal, 2020.
  13. Alves, Carla S.; Castillo, Mariangie; Pereira, Bruna; Tomás, Helena; Rodrigues, João Manuel Cunha. "A Ciência e a sua Divulgação - Projecto BtG by CQM". Trabalho apresentado em XV Colóquio CIE-UMa: LITERACIA CIENTÍFICA- Ensino, Aprendizagem e Quotidiano, Funchal, 2020.
    Publicado
  14. Mendes, Fátima; Olim, Filipe; Neves, Ana Rute; Rodrigues, João; Tomás, Helena. "Laponite®-based nanogels for Bone Tissue Regeneration.". Trabalho apresentado em 6th CQM Meeting, Porto Moniz, 2019.
    Publicado
  15. dos Orfaos, Lydia; Rodrigues, João; Tomás, Helena. "Fluorescent dendrimers - The fluorination approach". Trabalho apresentado em 6th CQM Annual Meeting, Porto Moniz, 2019.
  16. Neves, Ana Rute; Olim, Filipe; Luís, Andreia; Mendes, Fátima; Rodrigues, João; Tomás, Helena. "Marine-based nanomaterials for tissue engineering.". Trabalho apresentado em MAD-NANO18: Madeira International Conference on Emerging Trends and Future of Nanomaterials for Human Health, Funchal, 2018.
    Publicado
  17. Xiong, Zhijuan; Alves, Carla S.; Li, Aijun; Chen, Feng; Liu, Jinyuan; Shen, Mingwu; Tomas, Helena; Shi, Xiangyang. "A gene delivery approach using zwitterion-modified dendrimer-entrapped gold nanoparticles for inhibition of cancer cell metastasis". 2018.
  18. Xiao, Shili; Rodrigues, Joao; Tomas, Helena. "Laponite-based nanohybrids for enhanced solubility of dexamethasone and osteogenic differentiation of human mesenchymal stem cells". 2017.
    10.1016/j.jconrel.2017.03.250
  19. Zhan, Yuan; Goncalves, Mara; Yi, Panpan; Capelo, Debora; Zhang, Yuhong; Rodrigues, Joao; Liu, Changsheng; et al. "Thermo/Redox/pH-stimulative nanogel delivery systems". 2016.
    10.1016/j.nano.2015.12.337
  20. Kong, Lingdan; Hou, Wenxiu; Tomas, Helena; Shi, Xiangyang. "RGD peptide-modified dendrimer-entrapped goldnanoparticles enable effective gene delivery to stem cells". 2014.
  21. Li, Y.; Santos, J.L.; Maciel, D.; Tomás, H.; Rodrigues, J.; Li Y; Santos JL; et al. "Injectable hybrid laponite/alginate hydrogels for sustained release of methylene blue.". 2011.
    10.1016/j.jconrel.2011.08.119
  22. Sargo, S.; Santos, J. L.; Rodrigues, J.; Pego, A. P.; Granja, P. L.; Tomas, H.. "New Pamam dendrimers/alginate nanoparticles for gene delivery". 2008.
  23. Santos, J. L.; Rodrigues, J.; Pego, A. P.; Granja, P. L.; Tomas, H.. "Novel conjugates of dendrimers and fatty acids for gene delivery applications". 2008.
  24. Santos, J.; Oramas, E.; Pêgo, A.; Granja, P.; Tomás, H.. "In vitro osteoblastic differentiation of MSCs using PAMAM dendrimers as delivery vectors for the hBMP-2 gene". 2008.
Tese / Dissertação
  1. "Corrosion behaviour and cytocompatibility evaluation of a Co-Cr-Mo orthopaedic alloy". Doutoramento, Universidade de Lisboa, 1996.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/09/07 Tomás H.; Dendrimer-based nanomaterials for anticancer drug delivery; XL National Meeting of the Spanish Society of Pharmacology; Toledo, Spain; 6-8 September, page 38, 2023 (Invited keynote lecture)
2021 Castro R., Granja P. L., Rodrigues J., Pêgo A. P., Tomás H., Dendrimers and DNA: a promising marriage. XXVII Encontro Nacional Sociedade Portuguesa de Química (SPQ), Braga, Portugal 2021 (Invited)
2019 Tomás H., Rodrigues J., Laponite in drug delivery and tissue regeneration, MedTex19 & IFBMTM 2019, May 17-18, Shanghai, China, 2019 (Invited lecture)
2019 Tomás H., Laponite in nanomedicine, University of Donghua, Shanghai, China, 2019 (Invited lecture)
2019 H. Tomás, Designing nanomaterials for cancer cell targeting in therapeutics and diagnostics, First COST ACTION CA17140 Training School, Trieste, Italy (trainer in the school)
2013 Tomás H., Dendrimers and nucleic acid delivery, Donghua University, Shanghai (China, 2013) (Invited)
2012 Tomás H., Dendrimers and mesenchymal stem cells, Donghua University, Shanghai (China, 2012) (Invited)
2011 Tomás H., Different Strategies for Mesenchymal Stem Cells Differentiation, 8th Supraphone Meeting (Funchal, 2011) (Invited oral presentation)
2009 Tomás, H., Tissue regeneration via gene delivery, Summer Course on Biomaterials and Regenerative Medicine in the scope of the European Project BRIDGE (Funchal, 2009) (Invited)
2006 Tomás, H., Osteogenic differentiation - Extracellular Matrix Effects, 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies, SPCE-TC (Funchal, 2006) (Keynote Lecture)
2006 Tomás, H., Tissue Engineering Research in Madeira – A Gene Delivery Approach,1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for Tissue Engineering, Replacement and Regeneration (Funchal, 2006) (Keynote Lecture)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09/15 - Atual Laponite hydrogels for cisplatin delivery
Orientador de Ana Sofia Duarte
 Mestrado em Bioquímica Aplicada (Mestrado)
Universidade da Madeira, Portugal
2022/01/01 - Atual Novel stimuli-responsive nanoplatforms for osteosarcoma treatment based on biodegradable bone-targeted dendrimers
Orientador de Fátima Ferreira
 Chemistry (Doutoramento)
2019/12/01 - Atual Fucoidan/dendrimer-based nanosystems with targeting capabilities for glioblastoma theranostics
Orientador de José Filipe Olim
 Chemistry (Doutoramento)
Universidade da Madeira Centro de Química da Madeira, Portugal
2021/09/15 - 2022/11/04 Spheroid development for in vitro chondrogenesis
Orientador de Filipa Jardim
 Master in Applied Biochemistry (Mestrado)
Universidade da Madeira, Portugal
2017 - 2022 Post-DOCTORAl work: Ligand development by Phage Display Technology - application to bionanosensors for the diagnostic of infectious diseases. Grant from ARDITI (ARDITI-CQM/2017/009-PDG, in the scope of the project CQM+).
Orientador de Mariana Vieira
 Chemistry (Outra)
Universidade da Madeira Centro de Química da Madeira, Portugal
2018 - 2020 Laponite®-based nanogels for bone tissue regeneration
Orientador de Fátima Ferreira
 Applied Biochemistry (Mestrado)
2018 - 2019 Nanopartículas de colagénio para terapias da cartilagem baseadas em recursos marinhos
Orientador de Francisca Costa
 Applied Biochemistry (Mestrado)
2017 - 2019 Post-DOCTORAL work: Development of nanogels for biomedical applications based on marine resources (organic, inorganic or hybrid nanomaterials). Grant from ARDITI (ARDITI-CQM/2017/011-PDG, in the scope of the project CQM+)
Orientador de Ana Rute Neves
 Chemistry (Outra)
Universidade da Madeira Centro de Química da Madeira, Portugal
2013/09/01 - 2018/07/23 "DNA/Dendrimer-based films: a novel material with potential biomedical applications"
Orientador de Rita Maria de Castro
 Chemistry (Doutoramento)
Universidade da Madeira Centro de Química da Madeira, Portugal
2013/09/01 - 2018/07/05 Nanotechnology Approaches for the delivery of antitumor drugs, the case of doxorubicin
Orientador de Mara Isabel Jesus Gonçalves
 Chemistry (Doutoramento)
Universidade da Madeira Centro de Química da Madeira, Portugal
2011 - 2018 From 2011 until 2018, she supervised 14 Chinese students during internships at CQM (3 months) in the scope of an exchange program (Santander Chair) with the University of Donghua
Orientador de -
 Chemistry (Outra)
Universidade da Madeira Centro de Química da Madeira, Portugal
2016 - 2017 Preliminary studies on the use of exosomes as dendrimer carriers
Orientador de Filipe Olim
 Applied Biochemistry (Mestrado)
2013 - 2014 Gene delivery using dendrimer/pDNA complexes immobilized in electrospun fibers using the layer-by-layer technique
Orientador de Kirthiga Ramalingam
Nanochemistry and Nanomaterials (Mestrado)
2011 - 2014 Post-DOCTORAL work: New materials for biomedical applications obtained by the self-assembly of dendrimer-single stranded DNA conjugates. FCT grant (SFRH/BPD/75420/2010).
Orientador
 Chemistry (Outra)
Universidade da Madeira Centro de Química da Madeira, Portugal
2011 - 2012 Interação das células estaminais mesenquimais com um novo material de implante à base de hidroxiapatite e com multicamadas de polieletrólitos
Orientador de Daniel Lima
 Applied Biochemistry (Mestrado)
2009 - 2012 Post-DOCTORAL work: Biomimetic preparation of calcium phosphate nanoparticles using dendrimers as templates – application on gene delivery. FCT grant (SFRH/BPD/47369/2008).
Orientador de Alireza Nouri
 Chemistry (Outra)
Universidade da Madeira Centro de Química da Madeira, Portugal
2010 - 2011 New dendrimer-based vectors for antisense therapy
Orientador de Rita Castro
 Applied Biochemistry (Mestrado)
2010 - 2011 Avaliação do efeito dos dendrímeros com diferentes grupos funcionais na diferenciação de células estaminais mesenquimais
Orientador de Mara Gonçalves
 Ciências Biomédicas (Mestrado)
2009 - 2010 Encapsulation of single hMSCs in polyelectrolyte shells-preliminary studies
Orientador de Neide Freitas
 Applied Biochemistry (Mestrado)
2009 - 2010 Post-DOCTORAL work: Novel drug/gene delivery platforms based on the self-assembly of dendrimer-single strand DNA conjugates. FCT grant (SFRH/BPD/44821/2008).
Orientador de Deepti Pandita
 Chemistry (Outra)
Universidade da Madeira Centro de Química da Madeira, Portugal
2004/12/01 - 2009/09/18 Functionalization of Dendrimers for Improved Gene Delivery to Mesenchymal Stem Cells
Orientador de José Luís Santos
 Chemistry (Doutoramento)
Universidade da Madeira Centro de Química da Madeira, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019 - Atual Global Women’s Breakfast at CQM, in 2019, which has the general aim of Empowering Women in Science (2019)
Outro (Outra)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2019 - Atual Meeting of the Working Group 1 of COST Action CA17140: NANO2CLINIC-Cancer nanomedicine - from the bench to the bedside (Funchal, Portugal, 2019). (2019)
Oficina (workshop) (Coorganizador)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2014 - Atual NanoSchool 2014 - Advanced School (Invited scientist: Prof. Ruth Duncan, Cardiff University) (2014)
Outro (Outra)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2013 - Atual Madeira's participation in the European project Future2020: How will life be in 2020? Call: FP7-PEOPLE-2013-NIGHT, project 609809 (European Researchers' Night 2013). During this event, among other activities, she organized a TV debate with Madeira local TV (RTP Madeira). (2013)
Outro (Outra)
 Universidade da Madeira, Portugal
2011 - Atual FBPS 2011 - Frontiers in Biomedical Polymers (Funchal, Portugal, 2011) (2011)
Congresso (Outra)
2010 - Atual NanoSchool 2010 - Advanced School (Invited scientist: Prof. Mathias Epple, University of Duisburg-Essen) (2010)
Outro (Outra)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2009 - Atual 5th European Symposium on Biopolymers (ESBP2009, Funchal, Portugal, 2009). (2009)
Congresso (Coorganizador)
2009 - Atual Summer Course on Biomaterials and Regenerative Medicine no âmbito do projeto europeu BRIDGE (Funchal, Portugal, 2009 (2009)
Outro (Coorganizador)
2007 - Atual Organization of CQM participation in a set of 3 television science programs for «Panda Channel» which is a TV channel dedicated to children (2007)
Outro (Outra)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2007 - Atual 3rd Marie Curie Cutting Edge Conference: Biomineralisation of polymeric materials, bioactive biomaterials and biomimetic methodologies (Funchal, Portugal, 2007) (2007)
Congresso (Outra)
2006 - Atual 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies, SPCE-TC (Funchal, Portugal, 2006) (2006)
Conferência (Coorganizador)
2006 - Atual 1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for Tissue Engineering, Replacement and Regeneration (Funchal, Portugal, 2006) (2006)
Congresso (Outra)
2007 - 2019 Participation of CQM in the nationwide initiative promoted by the «Ciência Viva» agency, offering research internships for high school students during the summer (role: coordinator at CQM). (2007 - 2019)
Outro (Outra)
 Universidade da Madeira Centro de Química da Madeira, Portugal
2006 - 2019 A QUÍMICA É DIVERTIDA - SCIENCE DISSEMINATION ACTIVITY, Centro de Química da Madeira, Universidade da Madeira (open doors, funny experiments and visits to research labs) (2006 - 2019)
Outro (Outra)
 Universidade da Madeira Centro de Química da Madeira, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023 Analytical and in vitro cytotoxicity studies of synthetic cannabinoids found in seized ‘herbal incenses’.
Vogal
 Vera Alves (Doutoramento)
Universidade da Madeira, Portugal
2022 Magneto-plasmonic nanoassemblies using dendrimers: chemical synthesis and water quality monitoring
Arguente principal
 Tiago Fernandes (Doutoramento)
Instituto de Nanoestruturas Nanomodelação e Nanofabricação, Portugal
2019 Tissue Engineered In Vitro Models on a Chip for Cancer Research
Arguente principal
 Mariana Carvalho (Doutoramento)
Universidade do Minho, Portugal
2018 Nutraceuticals and functional foods for diabetes and obesity control
Vogal
 Vítor Spínola (Doutoramento)
Universidade da Madeira, Portugal
2018 DNA/dendrimer-based films. A novel material with potential biomedical applications
Orientador
 Rita Castro (Doutoramento)
Universidade da Madeira, Portugal
2018 Nanotechnology approaches for the delivery of antitumor drugs. The case of doxorubicin.
Orientador
 Mara Gonçalves (Doutoramento)
Universidade da Madeira, Portugal
2015 Non-invasive strategy in assessing asthma through biofluids metabolomics exploration: exhaled breath and urine potentialities
Vogal
 Michael Caldeira (Doutoramento)
2011 Computational and Experimental Strategies for Assessing the Conformational and Dynamic Properties of Proteins and peptides
Vogal
 Carla Alves (Doutoramento)
Universidade da Madeira, Portugal
2009 New nanotecnology approaches using dendrimers modified with natural polymers for controlling stem cells behaviour in tissue engineering strategies.
Arguente principal
 Joaquim Oliveira (Doutoramento)
Universidade do Minho, Portugal
2009 Functionalization of dendrimers for improved gene delivery to mesenchymal stem cells.
Orientador
 José Luís Santos (Doutoramento)
2008 Osteochondral tissue engineering constructs combining particle aggregated scaffolding and bioactive delivery strategies
Arguente principal
 Patrícia Malafaya Baptista (Doutoramento)
Universidade do Minho, Portugal
2003 Erros hereditários das purinas e pirimidinas: diagnóstico diferencial e caracterização molecular.
Vogal
 Helena Caldeira Araújo (Doutoramento)
2000 Estudo da influência dos ácidos gordos ¿-3 na composição dos lípidos e lipoproteínas do soro e na susceptibilidade das LDL à oxidação em dois grupos populacionais da ilha da Madeira
Vogal
 Isabel Torres (Doutoramento)
Universidade da Madeira, Portugal
1999 Avaliação da biocompatibilidade de ligas metálicas ortopédicas: estudos in vitro e in vivo
Arguente principal
 Isabel Bravo (Doutoramento)
Universidade de Aveiro, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/01/15 - Atual Pharmaceutics (1999-4923) MDPI
2013 - Atual Biomed Research International (Biomaterials area) (2314-6141) Hindawi Publishing Corporation

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2020 - Atual She served as an expert for the Science Fund of the Republic of Serbia
Especialista
2020 - Atual She served as an expert for the French Agence Nationale de la Recherche.
Especialista
2018 - Atual She served FCT as an evaluator in the 2018 Call for PhD grants of FCT (Materials Engineering and Nanotechnologies Panel)
Especialista
2021 - 2024 She served as expert for the European Commission in the monitoring of two research projects: 1) HADEA/A/03 ENDOSCAPE, a clinically applicable non-viral gene delivery technology (2022, 2023); 2) EISMEA H2020-FETOPEN-2018-2019-2020-01-899549-SCANnTREAT (2021, 2022, 2024).
Especialista
2019 - 2024 She served as evaluator for the European Commission in the calls: 1) HORIZON-HLTH-2024-TOOL-11-02 (Bio-printing of living cells for regenerative medicine); 2) HORIZON-EIC-2024-PATHFINDEROPEN-01; 3) HORIZON-WIDERA-2023-ACCESS-06 (Hop-on facility); 4) HORIZON-HLTH-2021-TOOL-06-02 (Next generation advanced therapies to treat highly prevalent and high burden diseases with unmet medical needs); 5) SC1-BHC-07-2019 (Regenerative medicine: from new insights to new applications).
Especialista
2014 - 2022 She served FCT as an evaluator of final project reports (2014, 2019-2022).
Especialista
2016 - 2020 She served as an expert for the Latvian Central Finance and Contracting Agency (2016-2020).
Especialista

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019 - Atual International adviser for the project Biomedical Textile Materials and Technology (since 01/03/2019, PI: Lu Wang) from Donghua University, funded by “Plan 111” promoted by the Ministry of Education and the Chinese State Administration of Foreign Experts Affairs.

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
1995 - Atual At the University of Madeira (Chemistry Department), she taught several courses, such as: General Chemistry, Biochemistry I and II, Cellular and Molecular Characterization Techniques (to the 1st Cycle in Biochemistry); Topics in Nanomedicine, Biomaterials and Tissue Engineering, Nanomaterials for Biomedical Applications (2nd Cycle in Applied Biochemistry and 2nd Cycle in Nanomaterials and Tissue Engineering).

Entrevista / Programa (rádio / tv)

Programa Tema
2018 - Atual EM ENTREVISTA (RTP Madeira) - Episódio 22 (2018) Nanomedicina
2020/08/15 - 2020/10/10 No Feminino - Antena 1 Madeira (conversas sobre a atualidade)

Membro de associação

Nome da associação Tipo de participação
1990/01/01 - Atual SPQ-Sociedade Portuguesa de Química Effective member
1989/09/01 - Atual Portuguese Order of the Engineer Specialty in Chemical and Biological Engineeering, Member number 29449 (effective), Level of qualification:E2
Distinções

Outra distinção

2019 Best Poster Presentation Award at the 11th International Dendrimers Symposium (student: Rita Castro)
2019 Member of the Portuguese Committee for the commemoration of the International Year of the Periodic Table of the Chemical Elements 2019.
2018 Portuguese Representative in the COST Action CA17140 NANO2CLINIC - Cancer nanomedicine - from the bench to the bedside (2018-2022) European Union funded.
Fundação para a Ciência e a Tecnologia, Portugal
2011 Portuguese Representative in the COST Action TD0802: Dendrimers in Biomedical Applications. (2010-2013) European Union funded.
Fundação para a Ciência e a Tecnologia, Portugal
2009 Best oral presentation at the 5th European Symposium on Biopolymers, ESBP 2009 (student: José Luís Santos)