???global.info.a_carregar???
Identificação

Identificação pessoal

Nome completo
Ana Margarida Tavares de Barros Santos Martins

Identificadores de autor

Ciência ID
3915-B3B9-9E68
ORCID iD
0000-0003-4822-3249

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
Formação
Grau Classificação
1995/10/01 - 2000/11/30
Concluído
 Biochemistry (Doutoramento)
Especialização em Outra:Enzimologia
Universidade de Lisboa, Portugal
"O Sistema dos Glioxalases e Metabolismo do Metilglioxal em Saccharomyces Cerevisiae" (TESE/DISSERTAÇÃO)
1990/01/01 - 1994/09/23
Concluído
 Bioquimica (Licenciatura)
Universidade de Lisboa Departamento de Química e Bioquímica, Portugal
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/07/01 - Atual Investigador (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/09/01 - 2019/02/28 Investigador visitante (Investigação) University of California Berkeley Research, Estados Unidos
California Institute for Quantitative Biosciences, Estados Unidos
2013/09/01 - 2016/05 Investigador (Investigação) American University of Sharjah College of Engineering, Emiratos Árabes Unidos
2010/10/01 - 2010/12/01 Investigador visitante (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/11/01 - 2009/04/30 Investigador (Investigação) Virginia Polytechnic Institute and State University Department of Biological Sciences, Estados Unidos
Virginia Polytechnic Institute and State University Department of Biological Sciences, Estados Unidos
2007/02/01 - 2008/07/31 Investigador (Investigação) Virginia Bioinformatics Institute, Estados Unidos
Virginia Bioinformatics Institute, Estados Unidos
2002/10/01 - 2007/01/31 Pós-doutorado (Investigação) Virginia Bioinformatics Institute, Estados Unidos
Virginia Bioinformatics Institute, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/09/01 - 2013/08/31 Professor Auxiliar Convidado (Docente Universitário) University of Sharjah, Emiratos Árabes Unidos
Projetos

Bolsa

Designação Financiadores
2013/09/01 - 2016/06/30 Ultrasound in Liposomal Drug Delivery
AUS Faculty Grant 2012
Investigador
American University of Sharjah, Emiratos Árabes Unidos
 American University of Sharjah
Em curso
2004/10/01 - 2007/02/28 A new mathematical modeling approach to biochemical networks, with an application to oxidative stress in yeast.
RO1 GM068947-01
Bolseiro de Pós-Doutoramento
Virginia Bioinformatics Institute, Estados Unidos
 National Institutes of Health
Concluído

Projeto

Designação Financiadores
2019/07/01 - Atual Ser4Skin
PTDC/MEC-DER/30198/2017
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Sandra Cordeiro; Beatriz Silva; Ana Margarida Martins; Helena Margarida Ribeiro; Lídia Gonçalves; Joana Marto. "Antioxidant-Loaded Mucoadhesive Nanoparticles for Eye Drug Delivery: A New Strategy to Reduce Oxidative Stress". Processes 9 2 (2021): 379-379. https://doi.org/10.3390/pr9020379.
    10.3390/pr9020379
  2. Bom, Sara; Fitas, Manuel; Martins, Ana Margarida; Pinto, Pedro; Ribeiro, Helena Margarida; Marto, Joana. "Replacing Synthetic Ingredients by Sustainable Natural Alternatives: A Case Study Using Topical O/W Emulsions". Molecules 25 21 (2020): 4887. http://dx.doi.org/10.3390/molecules25214887.
    10.3390/molecules25214887
  3. Bom, Sara; Santos, Catarina; Barros, Rita; Martins, Ana M.; Paradiso, Patrizia; Cláudio, Ricardo; Pinto, Pedro Contreiras; Ribeiro, Helena M.; Marto, Joana. "Effects of Starch Incorporation on the Physicochemical Properties and Release Kinetics of Alginate-Based 3D Hydrogel Patches for Topical Delivery". Pharmaceutics 12 8 (2020): 719. http://dx.doi.org/10.3390/pharmaceutics12080719.
    10.3390/pharmaceutics12080719
  4. Martins, Ana M.; Ascenso, Andreia; Ribeiro, Helena M.; Marto, Joana. "The Brain–Skin Connection and the Pathogenesis of Psoriasis: A Review with a Focus on the Serotonergic System". Cells 9 4 (2020): 796. http://dx.doi.org/10.3390/cells9040796.
    Publicado • 10.3390/cells9040796
  5. Ana M. Martins; Andreia Ascenso; Helena Margarida Ribeiro; Joana Marto. "Current and Future Therapies for Psoriasis with a Focus on Serotonergic Drugs". Molecular Neurobiology (2020): https://doi.org/10.1007/s12035-020-01889-3.
    10.1007/s12035-020-01889-3
  6. Salma E. Ahmed; Hesham G. Moussa; Ana M. Martins; Yassmine Abbas; Mohammad H. Al-Sayah; Ghaleb A. Husseini. "Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes". Journal of Nanoscience and Nanotechnology 19 11 (2019): 6899-6906. https://doi.org/10.1166%2Fjnn.2019.16646.
    10.1166/jnn.2019.16646
  7. Martins, A.M.; Latham, J.A.; Martel, P.J.; Barr, I.; Iavarone, A.T.; Klinman, J.P.; Martins, Ana M.; et al. "A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone". Journal of Biological Chemistry 294 41 (2019): 15025-15036. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073182857&partnerID=MN8TOARS.
    10.1074/jbc.RA119.009684
  8. N.M. Salkho; R.Z. Turki; O. Guessoum; A.M. Martins; R.F. Vitor; G.A. Husseini. "Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment". Current Molecular Medicine 17 10 (2018): 668-688. https://doi.org/10.2174%2F1566524018666180416100142.
    10.2174/1566524018666180416100142
  9. Najla M. Salkho; Vinod Paul; Pierre Kawak; Rute F. Vitor; Ana M. Martins; Mohammad Al Sayah; Ghaleb A. Husseini. "Ultrasonically controlled estrone-modified liposomes for estrogen-positive breast cancer therapy". Artificial Cells, Nanomedicine, and Biotechnology 46 sup2 (2018): 462-472. https://doi.org/10.1080%2F21691401.2018.1459634.
    10.1080/21691401.2018.1459634
  10. Rafeeq Tanbour; Ana M. Martins; William G. Pitt; Ghaleb A. Husseini. "Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review". Current Pharmaceutical Design 22 19 (2016): 2796-2807. https://doi.org/10.2174%2F1381612822666160217125215.
    10.2174/1381612822666160217125215
  11. Ana M. Martins; Rafeeq Tanbour; Mohammed A. Elkhodiry; Ghaleb A. Husseini. "Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study". European Journal of Nanomedicine 8 1 (2016): https://doi.org/10.1515%2Fejnm-2015-0045.
    10.1515/ejnm-2015-0045
  12. Mohamed A. Elkhodiry; Christian C. Momah; Shaima R. Suwaidi; Dina Gadalla; Ana M. Martins; Rute F. Vitor; Ghaleb A. Husseini. "Synergistic Nanomedicine: Passive, Active, and Ultrasound-Triggered Drug Delivery in Cancer Treatment". Journal of Nanoscience and Nanotechnology 16 1 (2016): 1-18. https://doi.org/10.1166%2Fjnn.2016.11124.
    10.1166/jnn.2016.11124
  13. Salma E. Ahmed; Hesham G. Moussa; Ana M. Martins; Mohammad H. Al-Sayah; Ghaleb A. Husseini. "Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes". European Journal of Nanomedicine 8 1 (2016): https://doi.org/10.1515%2Fejnm-2015-0046.
    10.1515/ejnm-2015-0046
  14. Hesham Moussa; Ana Martins; Ghaleb Husseini. "Review on Triggered Liposomal Drug Delivery with a Focus on Ultrasound". Current Cancer Drug Targets 15 4 (2015): 282-313. https://doi.org/10.2174%2F1568009615666150311100610.
    10.2174/1568009615666150311100610
  15. Ahmed, S.E.; Martins, A.M.; Husseini, G.A.; Salma E. Ahmed; Ana M. Martins; Ghaleb A. Husseini. "The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes". Journal of Drug Targeting 23 1 (2015): 16-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919904222&partnerID=MN8TOARS.
    10.3109/1061186X.2014.954119
  16. Ghaleb A. Husseini; William G. Pitt; Ana M. Martins. "Ultrasonically triggered drug delivery: Breaking the barrier". Colloids and Surfaces B: Biointerfaces 123 (2014): 364-386. https://doi.org/10.1016%2Fj.colsurfb.2014.07.051.
    10.1016/j.colsurfb.2014.07.051
  17. Wei Sha; Ana M. Martins; Reinhard Laubenbacher; Pedro Mendes; Vladimir Shulaev; Juan Mata. "The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide". PLoS ONE 8 9 (2013): e74939-e74939. https://doi.org/10.1371%2Fjournal.pone.0074939.
    10.1371/journal.pone.0074939
  18. Aloka B. Bandara; Stephen M. Boyle; Araceli Contreras-Rodriguez; Ana M. Martins; Rajiv Prasad; Christopher M. Reilly. "<i>Brucella melitensis</i> Differs from <i>B. suis</i> in Growth and Urease Activity <i>In-Vitro</i>, and Infectivity in Fisher-344 Rats <i>In-Vivo</i>". Advances in Infectious Diseases 03 01 (2013): 60-62. https://doi.org/10.4236%2Faid.2013.31008.
    10.4236/aid.2013.31008
  19. Martins, Ana. "Enzymatic, immunological and phylogenetic characterization of Brucella suis urease.". BMC microbiology (2008): http://europepmc.org/articles/PMC2492869.
    10.1186/1471-2180-8-121
  20. Martins, Ana. "'Model your genes the mathematical way'--a mathematical biology workshop for secondary school teachers". Teaching Mathematics and its Applications (2008): http://dx.doi.org/10.1093/teamat/hrn003.
    10.1093/teamat/hrn003
  21. Martins, Ana. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice.". BMC microbiology (2007): http://europepmc.org/articles/PMC1983905.
    10.1186/1471-2180-7-57
  22. Ana Margarida Martins; Wei Sha; Clive Evans; Susan Martino-Catt; Pedro Mendes; Vladimir Shulaev. "Comparison of sampling techniques for parallel analysis of transcript and metabolite levels inSaccharomyces cerevisiae". Yeast 24 3 (2007): 181-188. https://doi.org/10.1002%2Fyea.1442.
    10.1002/yea.1442
  23. A. Martins; D. Camacho; J. Shuman; W. Sha; P. Mendes; V. Shulaev. "A Systems Biology Study of Two Distinct Growth Phases of Saccharomyces cerevisiae Cultures". Current Genomics 5 8 (2004): 649-663. https://doi.org/10.2174%2F1389202043348643.
    10.2174/1389202043348643
  24. Ana Margarida Martins; Pedro Mendes; Carlos Cordeiro; Ana Ponces Freire. "In situ kinetic analysis of glyoxalase I and glyoxalase II inSaccharomyces cerevisiae". European Journal of Biochemistry 268 14 (2001): 3930-3936. https://doi.org/10.1046%2Fj.1432-1327.2001.02304.x.
    10.1046/j.1432-1327.2001.02304.x
  25. Ana Margarida T.B.S Martins; Carlos Alberto A Cordeiro; Ana Maria J Ponces Freire. "In situ analysis of methylglyoxal metabolism inSaccharomyces cerevisiae". FEBS Letters 499 1-2 (2001): 41-44. https://doi.org/10.1016%2Fs0014-5793%2801%2902519-4.
    10.1016/s0014-5793(01)02519-4
  26. Ana Margarida Martins; Carlos Cordeiro; Ana Ponces Freire. "Glyoxalase II inSaccharomyces cerevisiae: In SituKinetics Using the 5,5'-Dithiobis(2-nitrobenzoic Acid) Assay". Archives of Biochemistry and Biophysics 366 1 (1999): 15-20. https://doi.org/10.1006%2Fabbi.1999.1173.
    10.1006/abbi.1999.1173
  27. Ana Ponces Freire; Ana Margarida Martins; Carlos Cordeiro. "An experiment illustrating metabolic regulation in situ using digitonin permeabilized yeast cells". Biochemical Education 26 2 (1998): 161-163. https://doi.org/10.1016%2Fs0307-4412%2897%2900124-6.
    10.1016/s0307-4412(97)00124-6
  28. Ana Ponces Freire; Ana Margarida Martins; Carlos Cordeiro. "A practical experiment on cell permeabilization and biochemical characterisation in situ". Biochemical Education 26 1 (1998): 66-68. https://doi.org/10.1016%2Fs0307-4412%2897%2900125-8.
    10.1016/s0307-4412(97)00125-8
Capítulo de livro
  1. Martins, A.M.; Elgaili, S.A.; Vitor, R.F.; Husseini, G.A.. "Ultrasonic drug delivery using micelles and liposomes #37". 1127-1161. 2016.
  2. Martins, Ana. "SYSTEMS BIOTECHNOLOGY FOR INDUSTRIAL MICROORGANISMS". 2014.
    10.1201/b17104-16
  3. Martins, Ana. "Computational Systems Biology: Discrete Models of Gene Regulation Networks". 2013.
    10.5948/upo9781614443162.032

Outros

Outra produção
  1. Methods for Expression, Purification, and Characterization of PqqE, a Radical SAM Enzyme in the PQQ Biosynthetic Pathway. 2018. Wen Zhu; Ana M. Martins; Judith P. Klinman. https://doi.org/10.1016%2Fbs.mie.2018.04.002.
    10.1016/bs.mie.2018.04.002
  2. Ultrasonic Drug Delivery Using Micelles and Liposomes. 2016. Ana M. Martins; Salma A. Elgaili; Rute F. Vitor; Ghaleb A. Husseini. https://doi.org/10.1007%2F978-981-287-278-4_29.
    10.1007/978-981-287-278-4_29
Atividades

Membro de associação

Nome da associação Tipo de participação
2017/11 - Atual American Society for Biochemistry and Molecular Biology (ASBMB)
2006/08 - Atual American Association for the Advancement of Science (AAAS)
2001/06 - Atual The Biochemical Society
Distinções

Prémio

2008 Travel and fee award
Institute of Mathematics and its Applications, Reino Unido
2006 Travel Award, The Post Doctoral Travel Fund Program
Virginia Polytechnic Institute and State University, Estados Unidos
2005 Travel Award
2002 Postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1995 Ph.D. Fellowship
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2014 Scientific paper Martins, A.M. et al. (2001) FEBS Lett. 499, 41-44, chosen as one of the 12 representative of the high quality of biochemistry research carried out in Portugal in the last 50 years
Federation of European Biochemical Societies, Reino Unido