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I obtained my Bachelor's degree in Biology and my Master degree in Cellular and Molecular Biology, both at the University of Coimbra. During my bachelor's I joined the Centre for Functional Ecology for a 6-month voluntary internship in the project "Diversity of fungal species in ancient parchments collections of the Archive of the University of Coimbra", under the supervision of professor António Portugal, where I first gained experience in molecular biology techniques. During my Master thesis I joined the Neuronal Circuits and Behaviour group to study the impact of early-life stress on microglia and inhibitory neurons in the medial prefrontal cortex, under the supervision of Doctor Ana Luísa Cardoso. Throughout this period, I gained experience in numerous techniques including immunohistochemistry and confocal imaging, animal behaviour assays, cellular morphology analysis and 3D reconstruction, qRT-PCRs, as well as whole-cell patch clamp electrophysiology. After finishing my Master degree, I took a 3-month course on "Scientific Research Methodologies", with a FCT scholarship, where I had the opportunity to continue the investigation started in my Master thesis. After spending 8 months working as a laboratory technician at the COVID-19 laboratory of University of Coimbra, I was given the opportunity to go back to the NCBL group to work as a research technician in a very innovative and interesting project employing patient-derived immunocompetent brain organoids to study the disease mechanisms of frontotemporal dementia. This far I have been able to improve my electrophysiology skills, being now able to perform this technique both in acute animal brain slices and in human brain organoids. Additionally, I have acquired several new skills, including the isolation of human fibroblasts from human skin biopsies, reprogram and culture induced pluripotent stem cells (iPSC), differentiate these cells into human brain organoids and microglial cells that can be combined to originate immunocompetent brain organoids, and perform analysis of these organoids employing western blot, flow cytometry and immunohistochemistry.
Identificação

Identificação pessoal

Nome completo
Solange Martins

Nomes de citação

  • Martins, Solange

Identificadores de autor

Ciência ID
301E-7BDB-B351

Telefones

Telemóvel
  • 924346415 (Pessoal)

Moradas

  • Rua Larga, 2º Piso do Edifício FMUC, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2018/08/22 - 2020/10/29
Concluído
Cellular and Molecular Biology (Mestrado)
Especialização em Neurobiology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Impact of early life stress on microglia: neuron dynamic in the medial prefrontal cortex" (TESE/DISSERTAÇÃO)
18
2014/09/09 - 2018/01/10
Concluído
Biology (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2020/08/01 - 2020/10/31 Investigador (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2022/10/10 - Atual PhD Student Center for Neuroscience and Cell Biology, Portugal
Universidade de Coimbra, Portugal
2021/10/01 - 2022/10/01 Research Technician Centre for Neuroscience and Cell Biology, Portugal
Centre for Neuroscience and Cell Biology, Portugal
2021/01 - 2021/09/30 Laboratory technitian Laboratório de Análises Clínicas da Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2020/08/01 - 2020/10/30 Summer Course - Scientific Research Methodologies Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/02/01 - 2019/03/01 Laboratory Rotation in the project "Roles of SNAP29 in neuronal function and animal behaviour" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01/01 - 2019/02/01 Laboratory Rotation in the project "Understanding the contribution of miRNAs to neuroinflammation in Alzheime's disease" Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/01/15 - 2018/06/15 Voluntary internship in the project “Diversity of fungal species in ancient parchments collections of the Archive of the University of Coimbra” Centro de Ecologia Funcional, Portugal
Centro de Ecologia Funcional, Portugal
Projetos

Bolsa

Designação Financiadores
2020 - 2020/10/31 Impact of early life stress in the neuroimmune system and maturation of neuronal circuits
738342aa-fc12-4d77-a2a2-95e9a0539e0e
Bolseiro de Investigação
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Oliveira, Ana Rafaela; Martins, Solange; Cammarata, Giuseppe; Martins, Mariana; Cardoso, Ana Maria; Almeida, Maria Rosário; do Carmo Macário, Maria; et al. Autor correspondente: Cardoso, Ana Luísa. "Generation and Characterization of Novel iPSC Lines from a Portuguese Family Bearing Heterozygous and Homozygous GRN Mutations". Biomedicines 10 8 (2022): 1905. http://dx.doi.org/10.3390/biomedicines10081905.
  2. Costa, Jéssica; Martins, Solange; Ferreira, Pedro A.; Cardoso, Ana M.S.; Guedes, Joana R.; Peça, João; Cardoso, Ana L.. Autor correspondente: Cardoso, Ana L.. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512. http://dx.doi.org/10.1016/j.mad.2021.111512.
    Acesso aberto
Poster em conferência
  1. Costa, Jéssica; Martins, Solange; Ferreira, António Pedro A.; Franco, Lara ; Lebre, Carolina; Guedes, Joana; Peça, João; Cardoso, AL. "The influence of maternal bonding on neuroimmune synaptic sculpting". Trabalho apresentado em 13th Bial Symposium, 2022.
  2. Cardoso, Ana Luísa; Costa, Jéssica; Martins, Solange; Ferreira, Pedro; Guedes, Joana; Carvalho, Mário; Peça, João. "Early-life stress causes sex-dependent changes in microglia function, circuit wiring and behavior in the mPFC". Trabalho apresentado em 12th FENS Forum of Neuroscience, Glasgow, Scotland, 2020.
  3. Cardoso, A.; Costa, J.; Martins, Solange; Ferreira, P.; Guedes, J.; Carvalho, M.; Peça, J.. "Early-life stress causes sex-dependent changes in microglia function, circuit wiring and behavior in the mPFC". Trabalho apresentado em FENS Virtual Forum, 2020.
Atividades

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2021/02/01 - 2021/10/05 Python Core - Course
Outro
Python Core
SoloLearn, Estados Unidos
2020/01/23 - 2020/01/24 Mini-symposium "The Neurobiology of Socio-Sexual Behavior"
Simpósio
The neurobiology of socio-sexual behavior
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/13 - 2019/05/24 Drug Development - Course
Outro
Drug Development
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01/03 - 2019/02/08 Laboratory Rotation in the project "The neuroinflammatory reaction to acute systemic inflammation during delirium and its impact in the cognitive trajectory and progression to dementia: a casecontrol longitudinal study using imaging and molecular biomarkers"
Outro
Laboratory Rotation in the project "The neuroinflammatory reaction to acute systemic inflammation during delirium and its impact in the cognitive trajectory and progression to dementia: a casecontrol longitudinal study using imaging and molecular biomarkers"
Centre for Neuroscience and Cell Biology, Portugal
2018/03/03 - 2018/03/03 II Encontro de Laboratório - meet.Lab
Encontro
II Encontro de Laboratório - meet.Lab
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2017/04/07 - 2017/04/11 XX ENEB - Encontro Nacional de Estudantes de Biologia
Encontro
XX ENEB - Encontro Nacional de Estudantes de Biologia
Universidade de Aveiro, Portugal
2016/03/18 - 2016/03/22 IXI ENEB - Encontro Nacional Estudantes de Biologia
Encontro
IXI ENEB - Encontro Nacional Estudantes de Biologia
Universidade de Coimbra, Portugal