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Identificação

Identificação pessoal

Nome completo
Ana Rita Venceslau Fernandes

Nomes de citação

  • Fernandes, Ana Rita

Identificadores de autor

Ciência ID
2F11-7D27-1C13
ORCID iD
0000-0002-8787-7854

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Outras Ciências da Engenharia e Tecnologias
Formação
Grau Classificação
2017/07 - 2022
Em curso
 Programa Doutoral em Engenharia Biomédica (Doutoramento)
Especialização em Site-specific targeted therapy for Age-related Macular Degeneration: in vitro/ in vivo models
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
"Site-specific targeted therapy for Age-related Macular Degeneration: in vitro/ in vivo models " (TESE/DISSERTAÇÃO)
2017 - 2017
Concluído
 Cell Culture and Tissue Course-Beyond the Microscope, culturing Life (Curso médio)
Universidade de Coimbra, Portugal
2017 - 2017
Concluído
 Course on Laboratory of Animal Science - Category B (Curso médio)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2016
Concluído
 Mestrado em Tecnologias do Medicamento (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Enhancing the solubility of ibuprofen using biopolymers-based nanoencapsulation" (TESE/DISSERTAÇÃO)
 17
2011 - 2014
Concluído
 Química Medicinal (Licenciatura)
Universidade de Coimbra, Portugal
 12
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/01 - Atual Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/08 - 2019/01 Investigador (Investigação) Universidade de Coimbra, Portugal
2017/01 - 2017/08 Investigador (Investigação) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/01 - 2017/01 Estagiário de Investigação (Investigação) Instituto Nacional de Saúde Doutor Ricardo Jorge - PORTO, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/12 - 2018/12 Membro de Equipa Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Projetos

Bolsa

Designação Financiadores
2017/09 - 2021/10 Site-specific targeted therapy for Age-related Macular Degeneration: in vitro/ in vivo models
SFRH/BD/130555/2017
Bolseiro de Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluído

Projeto

Designação Financiadores
2017/02/01 - 2017/08/31 M-ERA-NET/0004/2015: PAIRED: Magnetically and photochemically actuated bioactive nanowires for remotely controlled drug delivery
M-ERA-NET/0004/2015: PAIRED
Bolseiro de Investigação
Concluído
Produções

Publicações

Artigo em conferência
  1. Souto, E.B.; Fernandes, Ana Rita Venceslau; Severino, P.; Durazzo, A.; Lucarini, M.; Atanasov, A. G.; Santini, A.. "ANTIOXIDANT AND ANTITUMOR ACTIVITY OF CROTON ARGYROPHYLLUS KUNTH LOADED IN LIPID NANOPARTICLES". Trabalho apresentado em Third National Conference Nanotechnologies and nanomaterials in the food sector and their safety assessment, Istituto Superiore di Sanità R, 2019.
    Publicado
  2. Fernandes, A.R.; Santos, A.C.; Veiga, F.J.; Silva, A.M.; Cabral, C.; Souto, E.B.. "Ibuprofen nanocrystals: production, characterization and cytotoxicity". Trabalho apresentado em 5th International Conference on Multifunctional, Hybrid and Nanomaterials, Lisbon, 2017.
    Publicado
  3. Teixeira, M.C.; Fernandes, A.R.; Kovacevic, A.B.; Sanchez-Lopez, E.; Espina, M.; Garcia, M.L.; Veiga, F.J.; Calpena, A.C.; Souto, E.B.. "Quinazolinediones-derivatives SIRT6 inhibitors for targeted selective nanochemotherapy". Trabalho apresentado em NanoBio&Med Conference, Barcelona, 2016.
    Publicado
  4. Fernandes, A.R.; Teixeira, M.C.; Santos, A.C.; Sanchez-Lopez, E.; Espina, M.; Garcia, M.L.; Veiga, F.J.; Calpena, A.C.; Souto, E.B.. "Metastatic skin cancers: identification of chemotherapeutic targets for nanotherapeutics". Trabalho apresentado em NanoBio&Med Conference, Barcelona, 2016.
    Publicado
Artigo em revista
  1. "Permeability, anti-inflammatory and anti-VEGF profiles of steroidal-loaded cationic nanoemulsions in retinal pigment epithelial cells under oxidative stress". International Journal of Pharmaceutics 617 (2022): 121615-121615. http://dx.doi.org/10.1016/j.ijpharm.2022.121615.
    10.1016/j.ijpharm.2022.121615
  2. Ana Rita Fernandes; Aleksandra Zielinska; Elena Sanchez-Lopez; Tiago dos Santos; Maria Luisa Garcia; Amelia M. Silva; Jacek Karczewski; Eliana B. Souto. "Exudative versus Nonexudative Age-Related Macular Degeneration: Physiopathology and Treatment Options". International Journal of Molecular Sciences 23 5 (2022): 2592-2592. https://doi.org/10.3390/ijms23052592.
    10.3390/ijms23052592
  3. Ana Fernandes; Elena Sánchez López; Tiago dos Santos; Maria L. Garcia; Amelia M. Silva; Amélia M Silva. "Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants". Materials (2021): https://www.mdpi.com/1996-1944/14/24/7541.
    10.3390/ma14247541
  4. Ana R. Fernandes; Elena Sanchez-Lopez; Antonello Santini; Tiago dos Santos; Maria L. Garcia; Amélia M. Silva; Eliana B. Souto. "Mono- and Dicationic DABCO/Quinuclidine Composed Nanomaterials for the Loading of Steroidal Drug: 32 Factorial Design and Physicochemical Characterization". Nanomaterials (2021): https://doi.org/10.3390/nano11102758.
    10.3390/nano11102758
  5. Ana R. Fernandes; Tiago dos Santos; Pedro L. Granja; Elena Sanchez-Lopez; Antonello Santini; Maria L. Garcia; Amelia M. Silva; Eliana B. Souto. "DABCO-Customized Nanoemulsions: Characterization, Cell Viability and Genotoxicity in Retinal Pigmented Epithelium and Microglia Cells". Pharmaceutics 13 10 (2021): 1652-1652. https://doi.org/10.3390/pharmaceutics13101652.
    10.3390/pharmaceutics13101652
  6. Fernandes, Ana. "Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals". Applied Sciences (2020): http://dx.doi.org/10.3390/app10051594.
    10.3390/app10051594
  7. Fernandes, Ana. "Nontoxic antimicrobial micellar systems based on mono- and dicationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships". Journal of Molecular Liquids (2019): http://dx.doi.org/10.1016/j.molliq.2019.112062.
    10.1016/j.molliq.2019.112062
  8. Fernandes, Ana. "Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications". International Journal of Molecular Sciences (2019): http://dx.doi.org/10.3390/ijms20225534.
    10.3390/ijms20225534
  9. Fernandes, Ana. "Evaluation of In Vitro Solar Protection Factor (SPF), Antioxidant Activity, and Cell Viability of Mixed Vegetable Extracts from Dirmophandra mollis Benth, Ginkgo biloba L., Ruta graveolens L., and Vitis vinífera L.". Plants (2019): http://dx.doi.org/10.3390/plants8110453.
    10.3390/plants8110453
  10. Fernandes, Ana. "Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles". Polymers (2019): http://dx.doi.org/10.3390/polym11101681.
    10.3390/polym11101681
  11. Fernandes, Ana. "Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties". Antioxidants (2019): http://dx.doi.org/10.3390/antiox8100443.
    10.3390/antiox8100443
  12. Fernandes, Ana. "Association of Platelet-Rich Plasma and Auto-Crosslinked Hyaluronic Acid Microparticles: Approach for Orthopedic Application". Polymers (2019): http://dx.doi.org/10.3390/polym11101568.
    10.3390/polym11101568
  13. Fernandes, Ana. "Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(e-caprolactone) Nanocapsules". Toxics (2019): http://dx.doi.org/10.3390/toxics7040051.
    10.3390/toxics7040051
  14. Fernandes, Ana. "Evaluation of the Influence of Process Parameters on the Properties of Resveratrol-Loaded NLC Using 22 Full Factorial Design". Antioxidants (2019): http://dx.doi.org/10.3390/antiox8080272.
    10.3390/antiox8080272
  15. Fernandes, Ana. "The Influence of Polysaccharide Coating on the Physicochemical Parameters and Cytotoxicity of Silica Nanoparticles for Hydrophilic Biomolecules Delivery". Nanomaterials (2019): http://dx.doi.org/10.3390/nano9081081.
    10.3390/nano9081081
  16. Pimentel-Moral, S.; Teixeira, M.C.; Fernandes, A.R.; Borrás-Linares, I.; Arráez-Román, D.; Martínez-Férez, A.; Segura-Carretero, A.; Souto, E.B.. "Polyphenols-enriched Hibiscus sabdariffa extract-loaded nanostructured lipid carriers (NLC): Optimization by multi-response surface methodology". Journal of Drug Delivery Science and Technology 49 49 (2019): 660-667.
    Publicado • 10.1016/j.jddst.2018.12.023
  17. Campos, Joana R.; Fernandes, Ana R.; Sousa, Raquel; Fangueiro, Joana F.; Boonme, Prapaporn; Garcia, Maria Luisa; Silva, Amelia M.; Naveros, Beatriz C.; Souto, Eliana B.. "Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line". Pharmaceutical Development and Technology 24 5 (2019): 616-622.
    Publicado • 10.1080/10837450.2018.1549075
  18. Fernandes, Ana R.; Santos, Ana C.; Sanchez-Lopez, Elena; Kova¿?evic, Andjekla B.; Espina, Marta; Calpena, Ana C.; Veiga, Francisco J.; Garcia, Maria L.; Souto, Eliana B.. "Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers". Skin Pharmacology and Physiology 31 2 (2018): 59-73.
    Publicado • 10.1159/000479529
  19. Fernandes, A.R.; Dias-Ferreira, J.; Cabral, C.; Garcia, M.L.; Souto, E.B.. "Release kinetics and cell viability of ibuprofen nanocrystals produced by melt-emulsification". Colloids and Surfaces B: Biointerfaces 166 166 (2018): 24-28.
    Publicado • 10.1016/j.colsurfb.2018.03.005
  20. Cefali, Letícia Caramori; Ataide, Janaína Artem; Eberlin, Samara; da Silva Gonçalves, Fernanda Cristina; Fernandes, Ana Rita; Marto, Joana; Ribeiro, Helena Margarida; et al. "In vitro SPF and Photostability Assays of Emulsion Containing Nanoparticles with Vegetable Extracts Rich in Flavonoids". AAPS PharmSciTech 20 1 (2018): 1-13.
    Publicado • 10.1208/s12249-018-1217-7
  21. Pimentel-Moral, S.; Teixeira, M.C.; Fernandes, A.R.; Arráez-Román, D.; Martínez-Férez, A.; Segura-Carretero, A.; Souto, E.B.. "Lipid nanocarriers for the loading of polyphenols – A comprehensive review". Advances in Colloid and Interface Science 260 260 (2018): 85-94.
    Publicado • 10.1016/j.cis.2018.08.007
  22. Campos, Joana R.; Fernandes, Ana R.; Severino, Patricia; Gracia, Maria L.; Souto, Selma B.; Souto, Eliana B.. "Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art". Current Pharmaceutical Design 24 21 (2018): 2508-2512.
    Publicado • 10.2174/1381612824666180522092740
  23. Fernandes, A.R.; Ferreira, N.R.; Fangueiro, J.F.; Santos, A.C.; Veiga, F.J.; Cabral, C.; Silva, A.M.; Souto, E.B.. "Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs". Saudi Pharmaceutical Journal 25 8 (2017): 1117-1124.
    Publicado • 10.1016/j.jsps.2017.07.004
  24. de Oliveira, G.G.G.; Feitosa, A.; Loureiro, K.; Fernandes, A.R.; Souto, E.B.; Severino, P.. "Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures". Saudi Pharmaceutical Journal nd (2016): nd-nd.
    Publicado • 10.1016/j.jsps.2016.05.001
Capítulo de livro
  1. Fernandes, Ana Rita. "Chapter 5 - Polymer nanogels: Fabrication, structural behavior, and biological applications". 2021.
    10.1016/B978-0-12-820466-5.00005-3
  2. "Multifunctional Nanocomposites for Biotherapeutic Applications". 1444-1472. {IGI, 2021.
    10.4018/978-1-7998-8591-7.ch060
  3. "In Vitro Methodologies for Toxicological Assessment of Drug Delivery Nanocarriers". 203-227. Springer International Publishing, 2021.
    10.1007/978-3-030-63241-0_8
  4. Fernandes, Ana. "Bioactive hybrid nanowires". 2020.
    10.1016/b978-0-12-817870-6.00001-8
  5. Fernandes, Ana Rita. "Biopolymer membranes in cosmetic sheet masks". 2020.
    DOI: 10.1016/B978-0-12-818134-8.00013-4
  6. Souto, Eliana B.; Fernandes, A. R.; Ferreira, J. Dias; da Silva, C. F.; Severino, Patrícia; Martins-Gomes, Carlos; Silva, Amélia M.. "Multifunctional Nanocomposites for Biotherapeutic Applications". In Multifunctional Nanocarriers for Contemporary Healthcare Applications, 328-356. IGI: IGI Global, 2018.
    Publicado • 10.4018/978-1-5225-4781-5.ch012
  7. Fernandes, Ana R.; Dias-Ferreira, João; Ferreira-da-Silva, Classius; Severino, Patrícia; Martins-Gomes, Carlos; Silva, Amélia M.; Souto, Eliana B.. "Drug nanocrystals". In Applications of Nanocomposite Materials in Drug Delivery, 239-253. Elsevier: Elsevier, 2018.
    Publicado • 10.1016/B978-0-12-813741-3.00011-X
  8. Fernandes, Ana. "Nanocrystals of Poorly Water-Soluble Drugs: Production Technologies, Characterization, and Functionalization". 2018.
    10.1201/9781351138901-9
  9. Fernandes, Ana. "Self-assembled quaternary ammonium surfactants for pharmaceuticals and biotechnology". 2018.
    10.1016/b978-0-12-813663-8.00014-2
  10. Fernandes, Ana. "Drug nanocrystals". 2018.
    10.1016/b978-0-12-813741-3.00011-x
  11. Fernandes, Ana. "Psoriasis vulgaris—Pathophysiology of the disease and its classical treatment versus new drug delivery systems". 2018.
    10.1016/b978-0-12-813667-6.00009-7
  12. Fernandes, Ana. "Nanopharmaceuticals in immunology". 2018.
    10.1016/b978-0-323-40016-9.00001-4
  13. Fernandes, A.R.; Martins-Gomes, C.; Santini, A.; Silva, A.M.; Souto, E.B.. "Psoriasis vulgaris – Pathophysology of the disease and its classical treatment versus new drug delivery systems, Pharmaceutical Nanotechnology". In Pharmaceutical Nanotechnology (multi volume SET I-XXVII), Chapter III – Lipid Nanocarriers, nd-nd. Europe: Elsevier, 2017.
    Publicado
  14. Zakharova, L.Y.; Pashirova, T.N.; Doktorovova, S.; Fernandes, A.R.; Martins-Gomes, C.; Silva, A.M.; Souto, E.B.. "Self-assembled Quaternary Ammonium Surfactants for Nanopharmaceutics". In Pharmaceutical Nanotechnology (multi volume SET I-XXVII), Chapter XII – Hybrid Nanostructures, nd-nd. Europe: Elsevier, 2017.
    Publicado
  15. Shegokar, R.; Fernandes, A.R.; Souto, E.B.. "Nanopharmaceuticals in immunology: what’s new in research?, Chapter 1". In Emerging Nanotechnologies in Immunology: The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines, nd-nd. Oxford, UK: Elsevier, 2017.
    Publicado
  16. Fernandes, A.R.; Ferreira, J.D.; da Silva, C.F.; Severino, P.; Souto, E.B.. "Nanocomposites and their applications in Dentistry, Orthopaedic and Drug Delivery systems". In Drug Nanocrystals, nd-nd. Europe: Elsevier, 2017.
    Publicado
  17. Vieira, V.; Fangueiro, J.F.; Fernandes, A.R.; Souto, E.B.. "Vectores lipídicos para o tratamento de carcinomas do tipo não melanoma - Capítulo XIII". In Nanopartículas Lipídicas para Dermofarmácia e Cosmética, nd-nd. Portugal: nd, 2017.
    Publicado
  18. Fernandes, A.R.; Santos, A.C.; Veiga, F.J.; Kovacevic, A.B.; Souto, E.B.. "Formulating pure nanocrystals for enhanced dissolution of poorly water-soluble drugs". In NanoBioMedicine, nd-nd. USA, Portugal: M/s Studium Press LLC, 2016.
    Publicado
Resumo em conferência
  1. Fernandes, A.R.; Severino, P.; Silva, A.M.; Souto, E.B.. "Nanosuspensions of poorly water-soluble drugs produced from melt-emulsification". Trabalho apresentado em 24th International Conference on Bioencapsulation, Lisbon, Portugal, 2016.
    Publicado
Tese / Dissertação
  1. Fernandes, Ana Rita Venceslau. "Enhancing the solubility of ibuprofen using biopolymers-based nanoencapsulation". Mestrado, 2016. http://hdl.handle.net/10316/36512.