Ana Rita Mendonça Vaz Botelho (121C-190C-DAC8)

Curriculum Vitae

Ana Rita Mendonça Vaz Botelho

Ana Rita Vaz (ARV) holds a Degree in Biochemistry (FCUL, 2006) and a PhD in Pharmacy-Molecular and Cellular Biology (FFUL, 2010). She was an FCT PhD fellow (2007-10), researching cellular targets for neurodevelopmental disorders, with training at the University of Salamanca in bioenergetics. Since 2011, ARV has studied microglia-neuronal communication in ALS (FCT Post-Doctoral Fellow, 2012-19) and trained in ALS mouse models (Universitat Autònoma de Barcelona). As a Junior Researcher (FFUL, 2019-20), she explored neuroinflammation and miRNA modulation. Currently, she is an Assistant Professor at FFUL and a Researcher at NeuroSignal lab, iMed.ULisboa, teaching Human Anatomy and Neurosciences. In Jan 2025, she became the Group Leader of NeuroSignal lab. Her research focuses on exosomes and microRNAs as potential therapies for neurodegenerative diseases, particularly ALS and, more recently, Alzheimer’s. She works with patient iPSC-derived neurons, in vivo (SOD1, 5XFAD mice), in vitro (cell lines, primary cultures), 3D cultures, and imaging/molecular biology techniques (Ciencia ID: 121C-190C-DAC8). ARV is involved in ALS/AD research projects (team member in La Caixa, FCT). She co-led an FCT project (2017-22) and was PI of the iMed.ULisboa Young Investigators' Project (2019-20). Since 2020, she has authored several studies on SOD1-ALS mice, MNs, astrocytes, and microglia, as first and senior author. She is the corresponding author of papers on exosomes as drug delivery systems (ORCID: 0000-0002-3418-3269) and was Guest Editor for Frontiers Pharmacol (Neurosignaling and Neuroregeneration, 2022-23). ARV has 43 peer-reviewed papers in neurosciences, neuroinflammation, and pharmacology, two book chapters, and numerous national/international presentations. h-index: 25 (Web of Science, 05/02/2025). She has supervised PhD students (2 completed, 1 ongoing), Master students (24 completed, 1 ongoing), 2 Post-Doctoral Junior Researchers, and Research Fellows in ALS/AD. In 2021, she completed the FELASA Cat B training to get accreditation to work with mice (Laboratory Animal Science Post-Graduated Course at FFUL).

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Identificação

Identificação pessoal

Nome completo: Ana Rita Mendonça Vaz Botelho

Nomes de citação

Vaz, Ana Rita
Vaz AR

Identificadores de autor

Ciência ID: 121C-190C-DAC8
ORCID iD: 0000-0002-3418-3269
Researcher Id: M-5149-2013
Scopus Author Id: 56383998000

Endereços de correio eletrónico

armvaz@ff.ulisboa.pt (Profissional)

Telefones

Fax

217946491 (Profissional)

Telefone

217946400 (Profissional)
219551168 (Pessoal)

Telemóvel

965236459 (Pessoal)

Moradas

Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa. Av. Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

https://www.ff.ulisboa.pt/bioquimica-e-biologia-humana/ (Profissional)
http://imed.ulisboa.pt/research/program-areas/drug-discovery/neuron-glia-biology-in-health-and-disease/ (Profissional)

Formação

	Grau	Classificação
2010 Concluído	Farmácia (Doutoramento) Especialização em Biologia Celular e Molecular Universidade de Lisboa Faculdade de Farmácia, Portugal "Identification of cellular targets for specific therapies in neurodevelopmental disorders" (TESE/DISSERTAÇÃO)	Aprovado com Distinção e Louvor
2006 Concluído	Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal "Avaliação dos mecanismos moleculares de imunomodulação do ácido glico-ursodesoxicólico em astrócitos de rato expostos à acção da bilirrubina não conjugada" (TESE/DISSERTAÇÃO)	16 (dezasseis) valores

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2025/01 - Atual	Investigador principal (carreira) (Investigação)	iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal
	iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal
2019/03/01 - 2020/12/30	Investigador Contratado (Investigação)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal
2005/09/01 - 2006/07/31	Estagiário de Investigação (Investigação)	Centro de Patogénese Molecular - UBMBE, Faculdade de Farmácia, Universidade de Lisboa, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2020/12/31 - Atual	Professor Auxiliar (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal (...)
2016/09/16 - 2018/09/15	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2016 - 2018	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa, Portugal

2013/09/16 - 2016/09/15	Assistente Convidado (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2013 - 2016	Assistente (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2012/01/01 - 2018/12/31	Post-Doctoral Fellow	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

2016/09/16 - 2018/09/15	Invited Assistant Professor (20%)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2013/09/16 - 2016/09/15	Invited Assistant (20%)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2012/06/01 - 2012/07/31	Visting Scientist	Institute of Neurosciences, Universitat Autònoma de Barcelona, Espanha

2011/01/01 - 2011/12/31	Post-Doctoral Researcher	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

2007/01/01 - 2010/12/31	PhD Student	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

2009/09/24 - 2009/09/30	Visiting PhD Student	Biochemistry and Molecular Biology Department, University of Salamanca, Salamanca, Espanha

2008/04/28 - 2008/05/21	Visiting PhD Student	Biochemistry and Molecular Biology Department, University of Salamanca, Salamanca, Espanha

2007/05/04 - 2007/07/21	Visiting PhD student	Biochemistry and Molecular Biology Department, University of Salamanca, Salamanca, Espanha

2006/09/01 - 2006/12/31	Research fellow, under the project POCTI/SAU-MMO/55955/2004	Centro de Patogénese Molecular - UBMBE, Faculdade de Farmácia, Universidade de Lisboa, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022/01/01 - 2025/12/31	Analyzing NeuroIMmune dysregulation in Alzheimer´s disease toward a Therapy with miRNA-loaded Exosomes PTDC/MED-NEU/2382/2021 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2021/10/01 - 2025/10/30	Targeting TDP-43 with protein kinase inhibitors: a effective and measurable therapy for ALS (Drugs4ALS) HR21-00931 Investigador	La Caixa Foundation-Luzón Foundation Em curso
2023/01/08 - 2023/04/08	Dissecting the role of exosome-miRNAs in Alzheimer's disease pathology using advanced human neuron-microglia models 9877	Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH Concluído
2019/01/01 - 2022/10/31	Detect, prevent, eradicate: a multi-step strategy to abrogate brain metastasization of breast cancer FCT - PTDC/MED-ONC/29402/2017 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2018/10 - 2022/09	NPSTEENSBRAIN. New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain Exposure Provided by PTCRIS: PTDC/SAU-TOX/32515/2017 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2018/08 - 2022/08	Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis ALS Provided by PTCRIS: PTDC/MED-NEU/31395/2017 Investigador responsável	Fundação para a Ciência e a Tecnologia Concluído
2016/01/01 - 2020/12/31	Exploring the impact of astrocyte-derived microvesicles for motor neuron degeneration and as vehicles to delivery neuroroprotective cargoes in ALS ELA-2015-002 Investigador iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal	Santa Casa da Misericórdia de Lisboa Em curso
2017/11/01 - 2019/06/06	Papel dos ectossomas na disseminação da infecção do HIV no SNC e seu contributo na patogénese da demência associada ao HIV n.d. Investigador iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal	Gilead Génese Concluído
2011/01/01 - 2019/02/28	Dissecting the mechanisms of microglia response, determinants and biomarkers in amyotrophic lateral sclerosis (ALS) SFRH/BPD/76590/2011 SFRH/BPD/76590/2011 Bolseiro de Pós-Doutoramento iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2017/01/01 - 2018/12/31	Identification and assessment of new psychoactive substances: a European network HOME/2014/JDRU/AG/DRUG/7086 Investigador	European Commission Seventh Framework Programme for Research and Technological Development Health Concluído
2016/01 - 2018/06	Generation of Improved Cellular and Animal Models for Identification of Disease Phenotype and New Therapeutic Targets of Alzheimer’s Disease JPCOFUND/003/2015 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2012/01 - 2017/12	DISSECTING THE MECHANISMS OF MICROGLIA RESPONSE, DETERMINANTS AND BIOMARKERS IN AMYOTROPHIC LATERAL SCLEROSIS Provided by PTCRIS: SFRH/BPD/76590/2011	Fundação para a Ciência e a Tecnologia
2014/03 - 2015/08	Decoding the regulation of microglia phenotype by microRNAs in Alzheimer's disease. Provided by PTCRIS: EXPL/NEU-NMC/1003/2013 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2012/01/01 - 2015/06/30	ARE MICROGLIA A NEW POTENTIAL PHARMACOLOGICAL TARGET IN AMYOTROPHIC LATERAL SCLEROSIS (ALS)? PTDC/SAU-FAR/118787/2010 Investigador iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/01/01 - 2010/12/31	Identification of cellular targets for specific therapies in neurodevelopmental disorders SFRH/BD/30292/2006 SFRH/BD/30292/2006 Bolseiro de Doutoramento iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/01/01 - 2010/12/31	Study of the blood-brain barrier disruption by neurotoxins and modulation by therapeutic agents in a human model: effects of bilirubin and endotoxin on brain microvascular endothelial cell monolayer integrity and protective role of bile acids PTDC/SAU-FCF/68819/2006 PhD student	Fundação para a Ciência e a Tecnologia
2007/07 - 2010/12	Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation Provided by PTCRIS: PTDC/SAU-NEU/64385/2006 PhD student	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2018/09/01 - 2022/08/31	Detetar, prevenir, erradicar: uma estratégia concertada para combater a metastização do cancro da mama para o encéfalo PTDC/MED-ONC/29402/2017	Fundação para a Ciência e a Tecnologia Em curso
2019/10/01 - 2021/12/31	Engineering hybrid exosomes as microRNAs nanocarriers to microglia in Amyotrophic Lateral Sclerosis UID/DTP/04138/2019 Investigador responsável iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal	iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa Fundação para a Ciência e a Tecnologia Em curso

Produções

Publicações

Artigo em revista	Évora, A; Garcia, Gonçalo; Rubi, Ana; De Vitis, Eleonora; Matos, Ana Teresa; Vaz, Ana Rita; Gervaso, Francesca; et al. "Exosomes enriched in miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron-glia crosstalk in Alzheimer's disease". Frontiers in Pharmacology 16 (2025): https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1474012/abstract. Acesso aberto Vaz, Ana Rita; Falcão AS; Palomo, Valle. Autor correspondente: Vaz, Ana Rita. "Editorial: Neurodegeneration, cell signaling and neuroreparative strategies, Volume II". Frontiers in Pharmacology 14 (2023): http://dx.doi.org/10.3389/fphar.2023.1198151. 10.3389/fphar.2023.1198151 Gonçalo Garcia; Sara Pinto; Sofia Ferreira; Daniela Lopes; Maria João Serrador; Adelaide Fernandes; Ana Rita Vaz; et al. "Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease". Cells (2022): https://doi.org/10.3390/cells11213377. 10.3390/cells11213377 Vaz, Ana Rita; Falcão, Ana Sofia; Palomo, Valle. Autor correspondente: Vaz, Ana Rita. "Editorial: Neurodegeneration, cell signaling and neuroreparative strategies". Frontiers in Pharmacology 13 (2022): https://doi.org/10.3389/fphar.2022.1059923. 10.3389/fphar.2022.1059923 Marta Barbosa; Marta Santos; Nídia de Sousa; Sara Duarte-Silva; Vaz AR; António J. Salgado; Dora Brites. Autor correspondente: Vaz AR. "Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092120. 10.3390/biomedicines10092120 Gomes, Cátia; Sequeira, Catarina; Likhite, Shibi; Dennys, Cassandra N.; Kolb, Stephen J.; Shaw, Pamela J.; Vaz, Ana R.; et al. Autor correspondente: Brites, Dora. "Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes". Cells 11 7 (2022): 1186. http://dx.doi.org/10.3390/cells11071186. 10.3390/cells11071186 Loch-Neckel, Gecioni; Matos, Ana Teresa; Vaz, Ana Rita; Brites, Dora. Autor correspondente: Vaz, Ana Rita. "Challenges in the Development of Drug Delivery Systems Based on Small Extracellular Vesicles for Therapy of Brain Diseases". Frontiers in Pharmacology 13 (2022): http://dx.doi.org/10.3389/fphar.2022.839790. 10.3389/fphar.2022.839790 Adelaide Fernandes; Cláudia Caldeira; Carolina Cunha; Elisabete Ferreiro; Ana Rita Vaz; Dora Brites. "Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice". Cells (2022): https://doi.org/10.3390/cells11010137. 10.3390/cells11010137 Vaz, A.R.; Falcão, A.S.; Palomo, V.. "Editorial: Neurodegeneration, cell signaling and neuroreparative strategies". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141176035&partnerID=MN8TOARS. 10.3389/fphar.2022.1059923 Ana Rita Vaz; Daniela Vizinha; Hermes Morais; Ana Rita Colaço; Gecioni Loch-Neckel; Marta Barbosa; Dora Brites. Autor correspondente: Ana Rita Vaz. "Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes". International Journal of Molecular Sciences 22 11 (2021): 6128-6128. https://doi.org/10.3390/ijms22116128. Acesso aberto • 10.3390/ijms22116128 Barbosa, M.; Gomes, C.; Sequeira, C.; Gonçalves-Ribeiro, J.; Pina, C.C.; Carvalho, L.A.; Moreira, R.; et al. "Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105432735&partnerID=MN8TOARS. 10.3389/fcell.2021.634355 Pomeshchik, Y.; Klementieva, O.; Gil, J.; Martinsson, I.; Hansen, M.G.; de Vries, T.; Sancho-Balsells, A.; et al. "Erratum: Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies (Stem Cell Reports (2020) 15(1) (256–273), (S2213671120301922), (10.1016/j.stemcr.2020.06.001))". Stem Cell Reports 16 11 (2021): 2838-2838. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118491121&partnerID=MN8TOARS. 10.1016/j.stemcr.2021.10.003 Pomeshchik, Y.; Klementieva, O.; Gil, J.; Martinsson, I.; Hansen, M.G.; de Vries, T.; Sancho-Balsells, A.; et al. "Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies". Stem Cell Reports 15 1 (2020): 256-273. http://www.scopus.com/inward/record.url?eid=2-s2.0-85087499545&partnerID=MN8TOARS. 10.1016/j.stemcr.2020.06.001 Vaz, A.R.; Falcão, A.S.; Scarpa, E.; Semproni, C.; Brites, D.. "Microglia Susceptibility to Free Bilirubin Is Age-Dependent". Frontiers in Pharmacology 11 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088787434&partnerID=MN8TOARS. 10.3389/fphar.2020.01012 de Mello-Sampayo, C.; Vaz, A.R.; Henriques, S.C.; Fernandes, A.; Paradinha, F.; Florindo, P.; Faria, P.; et al. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086428280&partnerID=MN8TOARS. 10.1007/s12640-020-00229-6 Gomes, C.; Sequeira, C.; Barbosa, M.; Cunha, C.; Vaz, A.R.; Brites, D.. "Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes". Experimental Cell Research 395 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090351924&partnerID=MN8TOARS. 10.1016/j.yexcr.2020.112209 Gomes, C.; Cunha, C.; Nascimento, F.; Ribeiro, J.A.; Vaz, A.R.; Brites, D.. "Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model". Molecular Neurobiology 56 3 (2019): 2137-2158. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049663582&partnerID=MN8TOARS. 10.1007/s12035-018-1220-8 Vaz, A.R.; Pinto, S.; Ezequiel, C.; Cunha, C.; Carvalho, L.A.; Moreira, R.; Brites, D.. "Phenotypic effects of wild-type and mutant SOD1 expression in n9 murine microglia at steady state, inflammatory and immunomodulatory conditions". Frontiers in Cellular Neuroscience 13 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85064224780&partnerID=MN8TOARS. 10.3389/fncel.2019.00109 Ferreira, C.; Vaz, A.R.; Florindo, P.R.; Lopes, Á.; Brites, D.; Quintas, A.. "Development of a high throughput methodology to screen cathinones’ toxicological impact". Forensic Science International 298 (2019): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062700246&partnerID=MN8TOARS. 10.1016/j.forsciint.2019.02.022 Braga, C.; Vaz, A.R.; Oliveira, M.C.; Matilde Marques, M.; Moreira, R.; Brites, D.; Perry, M.J.. "Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability". European Journal of Medicinal Chemistry 172 (2019): 16-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063613128&partnerID=MN8TOARS. 10.1016/j.ejmech.2019.03.048 Cunha, C.; Santos, C.; Gomes, C.; Fernandes, A.; Correia, A.M.; Sebastião, A.M.; Vaz, A.R.; Brites, D.. "Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage". Molecular Neurobiology 55 5 (2018): 4207-4224. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020723635&partnerID=MN8TOARS. 10.1007/s12035-017-0631-2 Fernandes, A.; Ribeiro, A.R.; Monteiro, M.; Garcia, G.; Vaz, A.R.; Brites, D.. "Secretome from SH-SY5Y APPSwecells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling". Biochimie (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048597442&partnerID=MN8TOARS. 10.1016/j.biochi.2018.05.015 Caldeira, C.; Cunha, C.; Vaz, A.R.; Falcão, A.S.; Barateiro, A.; Seixas, E.; Fernandes, A.; Brites, D.. "Key aging-associated alterations in primary microglia response to beta-amyloid stimulation". Frontiers in Aging Neuroscience 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030703999&partnerID=MN8TOARS. Falcão, A.S.; Carvalho, L.A.R.; Lidónio, G.; Vaz, A.R.; Lucas, S.D.; Moreira, R.; Brites, D.. "Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aß-Mediated Microglial Inflammation". ACS Chemical Neuroscience 8 1 (2017): 89-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013640037&partnerID=MN8TOARS. 10.1021/acschemneuro.6b00250 Pinto, S.; Cunha, C.; Barbosa, M.; Vaz, A.R.; Brites, D.. "Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in mir-124 and drive alterations in microglia phenotype". Frontiers in Neuroscience 11 MAY (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019549415&partnerID=MN8TOARS. 10.3389/fnins.2017.00273 Casas, Caty; Manzano, Raquel; Vaz, Ana Rita; Osta, Rosario; Brites, Dora. "Synaptic Failure: Focus in an Integrative View of ALS". Brain Plasticity 1 2 (2016): 159-175. http://dx.doi.org/10.3233/bpl-140001. Publicado • 10.3233/bpl-140001 Cunha, C.; Gomes, C.; Vaz, A.R.; Brites, D.. "Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization". Mediators of Inflammation 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008894491&partnerID=MN8TOARS. 10.1155/2016/6986175 Vaz, A.R.; Cunha, C.; Gomes, C.; Schmucki, N.; Barbosa, M.; Brites, D.. "Glycoursodeoxycholic Acid Reduces Matrix Metalloproteinase-9 and Caspase-9 Activation in a Cellular Model of Superoxide Dismutase-1 Neurodegeneration". Molecular Neurobiology 51 3 (2015): 864-877. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939875611&partnerID=MN8TOARS. 10.1007/s12035-014-8731-8 Brites, D.; Vaz, A.R.. "Microglia centered pathogenesis in ALS: Insights in cell interconnectivity". Frontiers in Cellular Neuroscience 8 MAY (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901445351&partnerID=MN8TOARS. 10.3389/fncel.2014.00117 Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Gomes, C.; Fernandes, A.; Barateiro, A.; Tiribelli, C.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Adverse secondary impacts". Neurotoxicity Research 26 1 (2014): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903741375&partnerID=MN8TOARS. 10.1007/s12640-013-9427-y Caldeira, C.; Oliveira, A.F.; Cunha, C.; Vaz, A.R.; Falcão, A.S.; Fernandes, A.; Brites, D.. "Microglia change from a reactive to an age-like phenotype with the time in culture". Frontiers in Cellular Neuroscience 8 JUN (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901848126&partnerID=MN8TOARS. 10.3389/fncel.2014.00152 Mariano, C.; Palmela, I.; Pereira, P.; Fernandes, A.; Falcão, A.S.; Cardoso, F.L.; Vaz, A.R.; et al. "Tricellulin expression in brain endothelial and neural cells". Cell and Tissue Research 351 3 (2013): 397-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881223461&partnerID=MN8TOARS. 10.1007/s00441-012-1529-y Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Early beneficial effects". Neurochemical Research 38 3 (2013): 644-659. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876416140&partnerID=MN8TOARS. 10.1007/s11064-012-0963-2 Barateiro, A.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "ER stress, mitochondrial dysfunction and calpain/jnk activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin". NeuroMolecular Medicine 14 4 (2012): 285-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870563054&partnerID=MN8TOARS. 10.1007/s12017-012-8187-9 Silva, S.L.; Vaz, A.R.; Diógenes, M.J.; Van Rooijen, N.; Sebastião, A.M.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10". Neuropharmacology 62 7 (2012): 2397-2407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859103402&partnerID=MN8TOARS. 10.1016/j.neuropharm.2012.02.002 Silva, S.L.; Osório, C.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Silva, R.F.M.; Brites, D.. "Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin". Journal of Neurochemistry 117 3 (2011): 412-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954420884&partnerID=MN8TOARS. 10.1111/j.1471-4159.2011.07200.x Palmela, I.; Cardoso, F.L.; Bernas, M.; Correia, L.; Vaz, A.R.; Silva, R.F.M.; Fernandes, A.; et al. "Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity". Current Neurovascular Research 8 2 (2011): 153-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955733304&partnerID=MN8TOARS. 10.2174/156720211795495358 Vaz, A.R.; Silva, S.L.; Barateiro, A.; Fernandes, A.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin". Experimental Neurology 229 2 (2011): 381-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137679&partnerID=MN8TOARS. 10.1016/j.expneurol.2011.03.004 Vaz, A.R.; Silva, S.L.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Selective vulnerability of rat brain regions to unconjugated bilirubin". Molecular and Cellular Neuroscience 48 1 (2011): 82-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960929537&partnerID=MN8TOARS. 10.1016/j.mcn.2011.06.008 Fernandes, A.; Barateiro, A.; Falcão, A.S.; Silva, S.L.-A.; Vaz, A.R.; Brito, M.A.; Marques Silva, R.F.; Brites, D.. "Astrocyte reactivity to unconjugated bilirubin requires TNF-a and IL-1ß receptor signaling pathways". GLIA 59 1 (2011): 14-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349235777&partnerID=MN8TOARS. 10.1002/glia.21072 Vaz, A.R.; Delgado-Esteban, M.; Brito, M.A.; Bolaños, J.P.; Brites, D.; Almeida, A.. "Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: Assessment of the protective effects of glycoursodeoxycholic acid". Journal of Neurochemistry 112 1 (2010): 56-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-71649114447&partnerID=MN8TOARS. 10.1111/j.1471-4159.2009.06429.x Silva, S.L.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation". Neurobiology of Disease 40 3 (2010): 663-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957807564&partnerID=MN8TOARS. 10.1016/j.nbd.2010.08.010 Brito, M.A.; Vaz, A.R.; Silva, S.L.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "N-methyl-D-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity". Molecular Medicine 16 9-10 (2010): 372-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956632156&partnerID=MN8TOARS. 10.2119/molmed.2009.00152 Fernandes, A.; Vaz, A.R.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin". Journal of Neuropathology and Experimental Neurology 66 9 (2007): 789-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548454884&partnerID=MN8TOARS. 10.1097/nen.0b013e3181461c74
Capítulo de livro	Vaz AR; Cunha, C.; Brites, D.. "Astrocytes in Amyotrophic Lateral Sclerosis: Harmful Effects and Strategies to Afford Neuroprotection". In New Developments in Astrocytes Research, 75-15. New York, Estados Unidos: Nova Science Publishers, Inc., 2016. Publicado Vaz AR; Fernandes, A.; Brites D.. "S100B as a Candidate Biomarker and Therapeutic Target in Neurodegenerative Disorders". In S100B: Serum Detection, Functions and Clinical Significance, 33-61. New York, Estados Unidos: Nova Science Publishers, Inc., 2015. Publicado
Poster em conferência	Garcia, G; Évora, Artemizia; Corraliza-Gomez, Miriam; Ianni, Marta; Ana Rubi; Matos, Ana Teresa; Rita Barbosa; et al. "Tailored exosomal miRNA-124-3p delivery: a targeted therapeutic approach for Alzheimer's disease". 2024. Corraliza-Gomez, Miriam; Barbosa, Marta; Ianni, Marta; Garcia, G; de Sousa, Nídia; Antonio SALGADO; Vaz, Ana Rita; Brites, Dora. "MiR-124 based therapies for neurodegeneration therapies for neurodegenerative disorders". 2023. Évora, Artemizia; Ana Rubi; Eleonora De Vitis; Ema Podobnik; Matos, Ana Teresa; Rita Barbosa; Vaz, Ana Rita; et al. "Engineering exosomal miR-124-3p for enhanced delivery and therapeutic translation using human neuron-microglia-astrocyte triculture models of AD". Trabalho apresentado em 14th iMed.ULisboa Meeting 2023, 2023. Garcia, Gonçalo; Vaz, Ana Rita; Brites, Dora. "Hippocampal miR-21 upregulation by SH-SY5Y APP SWE cell transplantation is associated with microglial activation, astrocyte reactivity and PPARa suppression". Trabalho apresentado em FENS Regional Meeting 2023, 2023. Matos, Ana Teresa; Borralho-Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita. Autor correspondente: Matos, Ana Teresa. "miRNA Engineering of Pathological Microglia as a Promising Therapeutic Strategy for Amyotrophic Lateral Sclerosis". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting, 2023. Matos, Ana Teresa; Raquel Martin Baquero; Marta Gómez-Almería; Ana Martínez; Carmen Rodríguez-Cueto; Eva de Lago; Vaz, Ana Rita; Brites, Dora. "Promise of a Protein CK-1d Inhibitor for Reshaping Inflammatory miRNAs in the TDP-43 (A315T) Transgenic Mice". Trabalho apresentado em VII Symposium of th Portuguese Glial Network, 2023. Évora, Artemizia; Garcia, Gonçalo; Ana Rubi; Ema Podobnik; Matos, Ana Teresa; Rita Barbosa; Vaz, Ana Rita; Brites, Dora. "Promising Alzheimer's disease therapeutic strategy based on miR-124- 3p engineered exosomes". Trabalho apresentado em 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2023. Garcia, Gonçalo; Costa-Pinto, Sara; Ferreira, Sofia; Daniela Lopes; Serrador MJ; Fernandes, Adelaide; Vaz, Ana Rita; et al. "miR-21-5p: a new possible therapeutic target in Alzheimer's disease". 2022. Ana Rubi; Garcia, Gonçalo; Vaz, Ana Rita; Brites, Dora. "Engineering Small Extracellular Vesicles with miR-124-3p as a Future Therapeutic Strategy in Alzheimer's Disease". 2022. Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Inhibiting miR-125b overexpression in ALS spinal microglia restores their homeostatic profile". Trabalho apresentado em VI Symposium of the Portuguese Glia Network, 2022. Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Vaz, Ana Rita; António J. Salgado; Brites, Dora. "Secretome from anti-miR-124-treated ALS motor neurons shows therapeutic potential after intrathecal injection in the early symptomatic ALS mouse model". Trabalho apresentado em The Federation of European Biochemical Societies (FEBS) Congress, 2022. Santos, Marta; Barbosa, Marta; de Sousa, Nídia; Vaz, Ana Rita; António J. Salgado; Brites, Dora. "Secretome from anti-miR-124-treated ALS motor neurons prevents microglia and inflammatory miRNA dysfunction after intrathecal injection in mSOD1 mice". Trabalho apresentado em 13th iMed.ULisboa Postgraduate Students Meeting, 2022. Ana Rubi; Garcia, Gonçalo; Vaz, Ana Rita; Brites, Dora. "Emerging prospects of small extracellular vesicles with miR-124-3p as a therapeutic strategy in Alzheimer's disease". Trabalho apresentado em 13th iMed.ULisboa Postgraduate Students Meeting, 2022. Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "miR-125b inhibitor recovers microglial homeostatic profile conveying neuroprotection in ALS". Trabalho apresentado em iMed.ULisboa Meeting 2022, 2022. Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Vaz, Ana Rita; António J. Salgado; Brites, Dora. "Intrathecal injection of the secretome from anti-miR-124 treated pathological MNs in ALS mice provides neuroprotection". Trabalho apresentado em Encontro Ciência ‘22, 2022. Garcia, Gonçalo; Costa-Pinto, Sara; Daniela Lopes; Ferreira, Sofia; Serrador MJ; Fernandes, Adelaide; Vaz, Ana Rita; et al. "Dysregulation of miR-21: a new wave in the pathogenesis of Alzheimer's disease by dysfunctional neuron-glia communication". 2022. Vaz, Ana Rita; Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Barbosa, Marta; Brites, Dora. "Regeneration of microglia homeostasis and paracrine signaling in models of spinal ALS disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neurosciences, 2021. Barbosa, Marta; de Sousa, Nídia; Vaz, Ana Rita; António Salgado; Brites, Dora. "Intrathecal injection of secretome from anti-miR-124-treated ALS motor neurons in mSOD1 mice shows promise as a therapeutic strategy. V Symposium of the Portuguese Glial Network, 30 Nov 2021, Coimbra". Trabalho apresentado em V Symposium of the Portuguese Glial Network, 2021. Barbosa, Marta; Santos, Marta; de Sousa, Nídia; Duarte-Silva, S; Vaz, Ana Rita; António J. Salgado; Brites, Dora. "Intrathecal injection of secretome from anti-miR-124-treated ALS motor neurons in mSOD1 mice shows promise as a therapeutic strategy". Trabalho apresentado em V Symposium of the Portuguese Glial Network, 2021. Paulo Faria; CRESPO, HÉLIO J.; Vaz, Ana Rita; Brites, Dora. "Emergent new psychoactive substances (NPS) cause neuronal and microglial dysfunction". Trabalho apresentado em XXI Congresso da Sociedade Portuguesa de Bioquímica, 2021. Barbosa, Marta; Gomes, Cátia; Vaz, Ana Rita; Brites, Dora. "Reshape of miR-146a in ALS cortical astrocytes modulates inflammatory miRNA signature in cells and in their small extracellular vesicles". Trabalho apresentado em SNEV International Virtual Conference, 2021. Martins, Nísia; Matos, Ana Teresa; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Testing the Benefits of the miRNA-Reshaped Secretome from Motor Neurons in Spinal 3D Cultures Using ALS Models". Trabalho apresentado em IMed.ULisboa Meeting 2021, 2021. Matos, Ana Teresa; Martins, Nísia; Loch-Neckel, Gecioni; Vaz, Ana Rita; Brites, Dora. "Studying the Benefits of the Regulation of Inflammatory-miRNAs in Rescuing Microglia Function in ALS". Trabalho apresentado em IMed.ULisboa Meeting 2021, 2021. Barbosa, Marta; Santos, M; de Sousa, Nídia; Vaz, Ana Rita; Salgado, António; Brites, Dora. "Intrathecal injection of secretive from anti-miRNA-124-Treated ALS motor neurons in MSOD1 mice shows promise as a therapeutic strategy". Trabalho apresentado em V Symposium of Portuguese Glial Network, Coimbra, Portugal., 2021. Barbosa, Marta; Gomes, Cátia; Carvalho, Luís; Moreira, Rui; Vaz AR; Brites, Dora. "Benefits of VS in Counteract ALS-astrocyte Aberrancy Involves miR-146a Upregulation". Trabalho apresentado em 11th iMed.ULisboa Students Meeting, 2019. Colaço, Ana Rita; Morgado, Patrícia; Vaz AR; Brites. Dora. "Unveiling the Influence Of mSOD1 MNs-Derived Secretome on mSOD1 Mice Spinal Microglia Polarization". Trabalho apresentado em 11th iMed.ULisboa Students Meeting, 2019. Sequeira C; Vizinha D; Colaço AR; Vaz AR; Brites, Dora. "Targeting of miR-124 in ALS motor neurons prevents neuro-immune dysregulation [presenting author]". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, 2019. Barbosa, Marta; Gomes, Cátia; Carvalho, Luís; Moreira, Rui; Vaz AR; Brites, Dora. "Glycoursodeoxycholic acid and dipeptidyl vinyl sulfone counteract reactivity and inflammatory miRNAs in ALS mouse cortical astrocytes". Trabalho apresentado em IV Symp PT Glial Network, 2019. Sequeira, Catarina; Colaço, Ana Rita; Vizinha, Daniela; Vaz AR; Brites, Dora. "Targeting miR-124 in ALS motor neurons to prevent neurodegeneration and glial activation". Trabalho apresentado em IV Symp PT Glial Network, 2019. Barbosa, Marta; Gomes, Cátia; Vaz, Ana Rita; Brites, Dora. "Targeting miRNA-146a downregulation in mSOD1 cortical astrocytes to modulate inflamma-miRNA profile in exosomes". Trabalho apresentado em 1st International Symposium: Secretome without Borders, 2018. Gomes, Cátia; Barbosa, Marta; Cunha, Carolina; Vaz AR; Brites, Dora. "Spine/Cortical ALS Astrocytes Show Features of Aberrant Phenotype Diversity by In Vitro Ageing". Trabalho apresentado em 4th meeting of the Mind-Brain College ULisboa, 2018. Sequeira C; Vizinha D; Vaz AR; Brites, Dora. "Aberrancy of ALS spine astrocytes is exacerbated by factors released from activated microglia and counteracted by anti-miRNA-155 [presenting author]". Trabalho apresentado em 4th PhD Students Meeting of the Mind-Brain College of Universidade de Lisboa, 2018. Vizinha D; Sequeira C; Vaz AR; Brites, Dora. "Elevated expression of miR-124 is associated with motor neuron impairment in ALS and contributes to glia reactivity". Trabalho apresentado em 4th PhD Students Meeting of the Mind-Brain College of Universidade de Lisboa, 2018. Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites, Dora. "Decreased Exosomal miR-146a as a Biomarker of Dysfunctional Cortical mSOD1 Astrocytes and Therapeutic Target in Exosomal Trans-Dissemination". Trabalho apresentado em 10th iMed.ULisboa Postgraduate Students Meeting, 2018. Sequeira, Catarina; Vizinha, Daniela; Vaz AR; Brites. Dora. "Aberrant ALS Spinal Astrocyte Phenotype is Exacerbated by Neuroinflammation and not Counteracted by miR-155 Targeting". Trabalho apresentado em 10th iMed.ULisboa Postgraduate Students Meeting, 2018. Vizinha, Daniela; Sequeira, Catarina; Vaz AR; Brites, Dora. "MiR-124 Targeting in ALS Motor Neurons Reduces Genes Associated with Alarmin Production and Synaptic Loss, while Favours Anterograde Axonal Transport". Trabalho apresentado em 10th iMed.ULisboa Postgraduate Students Meeting, 2018. Vaz AR; Sequeira, Catarina; Vizinha, Daniela; Barbosa, Marta; Gomes, Cátia; Brites, Dora. "Targeting astrocyte and motor neuron specific miRNAs to recover cell function in ALS". Trabalho apresentado em Workshop on integrative approaches in neurodegeneration, 2018. Barbosa, Marta; Gomes, Cátia; Vaz, Ana Rita; Brites, Dora. "Upregulation of miR-146a in ALS mouse cortical astrocytes decrease their reactivity and prevents miR-155 transfer into exosomes". Trabalho apresentado em ENCALS, 2018. Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites, Dora. "Restitution of miR-146a expression in ALS mouse cortical astrocytes counteracts cell aberrancy and changes inflammatory miRNA content in their derived exosomes". Trabalho apresentado em III Symposium PT Glial Network, 2018. Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites, Dora. "Upregulation of miR-146a attenuates ALS mouse cortical astrocytes reactivity and decrease miRNA-inflammatory associated exosomal cargo". Trabalho apresentado em XX Meeting of Portuguese Society for Biochemistry (SPB) and Society for Free Radical Research International (SFRRI), 2018. Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites. Dora. "Upregulation of miR-146a in the ALS mouse cortical astrocytes has benefits on cell aberrancy and inflammation dissemination by extracellular vesicles". Trabalho apresentado em 1st Meeting in Vesicular Biology, 2018. Vaz AR; Cunha, Carolina; Gomes, Cátia; Brites, Dora. "Reactive astrocytes from the spinal cord of mSOD1 mice pups trigger microglia M1 polarization, while switch mSOD1 microglia into M1/M2 phenotypes that lately become irresponsive". Trabalho apresentado em XIII European Meeting on Glial Cells in Health and Disease, 2017. Cunha, Carolina; Gomes, Cátia; Vaz AR; Brites, Dora. "Differently aged microglia from the spinal cord of SOD1G93A mice show diverse polarized phenotypes, which are exacerbated by co-incubation with their counterpart astrocyte". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017. Ezequiel, Catarina; Cunha, Carolina; Vaz AR; Brites, Dora. "SOD1G93A transduced microglia show a depressed inflammatory response to LPS". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017. Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites, Dora. "Recovery of miR-146a levels through overexpression reverts astrocyte reactivity in cells from ALS mice and modulate astrocytic exosome cargo". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017.
Resumo em conferência	Vaz AR; Pinto, Sara; Ezequiel, Catarina; Cunha, Carolina; Carvalho, Luís; Moreira, Rui; Brites, Dora. "Overexpression of wild-type and mutant SOD1 in N9 microglia upon steady-state, inflammatory and immunomodulatory conditions leads to distinct phenotypes". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, Porto, 2019. Sequeira, Catarina; Vizinha, Daniela; Colaço, Ana Rita; Vaz AR; Brites, Dora. "Targeting of miR-124 in ALS motor neurons prevents neuro-immune dysregulation". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, Porto, 2019. Publicado Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites, Dora. "Restoring miR-146a levels in ALS mouse cortical astrocytes rescues their aberrant phenotype and abolishes inflammatory miRNA dysregulation in cells and derived sEVs". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, porto, 2019. Publicado Vaz AR; Sequeira, Catarina; Vizinha, Daniela; Barbosa, Marta; Gomes, Cátia; Brites, Dora. "Targeting astrocyte and motor neuron specific miRNAs to prevent neuro-immune dysregulation in ALS". Trabalho apresentado em SPN XVI Meeting, Lisboa, 2019. Publicado Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites, Dora. "Targeting miR-146a downregulation in cortical astrocytes from the ALS mouse as a therapeutic strategy in the rescue of cell aberrant phenotype and inflammatory miRNA in their derived exosomes". Trabalho apresentado em XLVII Reunião Annual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Publicado Ezequiel, Catarina; Cunha, Carolina; Vaz AR; Brites, Dora. "Glycourseodexycholic acid and dipeptidyl vinyl sulfone differently control the pro-inflammatory phenotype of mutant SOD1G93A microglia". Trabalho apresentado em XLVII Reunião Annual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Publicado Barbosa, Marta; Gomes, Cátia; Vaz AR; Brites. Dora. "Recovery of miR-146a levels through overexpression reverts astrocyte reactivity in cells from ALS mice and modulate astrocytic exosome cargo". Trabalho apresentado em . II Symposium of the Portuguese Glial Network- Glial Cells: Much More Than Glue, Braga, 2017. Publicado Gomes, Cátia; Cunha, Carolina; Nascimento, Filipe; Sebastião, Ana M; Vaz AR; Brites, Dora. "Dysfunctional Astrocytes as the major glial contributors to Motor Neurons loss in the cerebral cortex of ALS mice model". Trabalho apresentado em XIX National Congress of Biochemistry, Guimarães, 2016. Publicado
Tese / Dissertação	Botelho, Ana. "Identification of cellular targets for specific therapies in neurodevelopmental disorders". Doutoramento, Universidade de Lisboa Faculdade de Farmácia, 2010.

Outros

Outra produção

Cellular mechanisms underlying dysfunction of immature neurons by hyperbilirubinemia and inflammation. 2007. Vaz, Ana Rita; Silva, Sandra L.; Fernandes, Adelaide; Falcao, Ana Sofia; Silva, Rui F. M.; Brito, M. Alexandra; Brites, Dora. http://hdl.handle.net/10451/21554.
Profile of early microglial activation by unconjugated bilirubin. 2007. Silva, Sandra L.; Vaz, Ana Rita; Fernandes, Adelaide; Falco, Ana S.; Brito, M. Alexandra; Silva, Rui F. M.; Brites, Dora. http://hdl.handle.net/10451/21553.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2021/09/13	Re-establishment of miR-146a levels in ALS cortical astrocytes prevents inflammatory dissemination by modulation of inflamma-miRNA profile in cells and small extracellular vesicles.	st meeting of the Portuguese Network on extracellular vesicles Portuguese Network on extracellular vesicles (Porto)
2021/02/18	Overexpression of miR-124 in motor neurons plays a key role in ALS pathological process	51th meeting of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Lisbon, Portugal)
2021/02/17	Targeting depressed miR-146a in ALS cortical astrocytes inhibits phenotypic aberrancies and Cell paracrine damage	39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia Portuguese Society of Pharmacology (virtual, Portugal)
2021/02/17	Emergent new psychoactive substances (NPS) trigger neuroinflammation and other neurotoxic responses on neurons and microglia.	51.ª Reunião da Sociedade Portuguesa de Farmacologia. 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia Portuguese Society of Pharmacology (virtual)
2019/11/15	Targeting microRNAs in glia & motor neurons to restore neuro-immune function in ALS	Neuroscience Seminars Neuropharmacology Group, Instituto de Medicina Molecular (lisboa, Portugal)
2019/05/31	Targeting astrocyte and motor neuron specific miRNAs to prevent neuro-immune dysregulation in ALS	SPN 2019 Society of Portuguese Neurosciences (Lisboa, Portugal)
2019/05/29	Astrocyte phenotypic aberrancy differs from the spinal cord to the cortical brain in ALS disease	IV Symposium of Portuguese Glial Network Portuguese Glial Network (Lisboa, Portugal)
2018/06	Aberrant Glia Reactivity and Inflammatory miRNAs as Therapeutic Targets and Biomarkers for Tracking the Progression of Amyotrophic Lateral Sclerosis	Encontro com a Ciência e Tecnologia em Portugal 2018 Fundação de Ciência e Tecnologia (Lisboa, Portugal)
2018/02/07	Glycoursodeoxycholic acid and dipeptidyl vinyl sulfone differently control the pro-inflammatory phenotype of mutant SOD1G93A microglia.	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2016/10/14	Dissecting Aß-induced inflammatory signaling mediators associated to HMGB1 overexpression in an in vitro model of reactive microglia.	HMGB1 Workshop (Milan, Itália)
2016/06/03	Modulating HMGB1 in microglia as a promising strategy to inhibit specific Aß-induced inflammatory pathways.	30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisb, Portugal)
2016/06/03	Exosomes as mediators of neuroinflammation and pathogenicity in ALS	30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência Grupo de Estudos de Envelhecimento Cerebral e Demência (Lisboa, Portugal)
2016/04/22	Motor neuron dysfunction in ALS.	Simpósio ELA: Ciência e Sociedade Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
2015/12/01	Upregulation of miR-155 and deregulated cell-cell signaling precede inflammation in the spinal cord of symptomatic TgSOD1G93A mice.	1st Spinal Cord Injury Iberian Symposium (Alcoitão, Portugal)
2014/03/14	Profiling microglial reactivity in a mice model of Amyotrophic Lateral Sclerosis.	2nd Symposium of Pathophysiology of Glial Cell Instituto de Ciências da Saúde – Universidade Federal Bahia (Bahia, Brasil)
2013/06/01	Exploring anti-inflammatory strategies on motor neuron degeneration in ALS.	Portuguese Society for Neurosciences 13th Meeting Portuguese Society for Neurosciences (Luso, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2024/09 - Atual	Exploring acellular stratification in neurodegenerative diseases Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/09 - Atual	Mitigation of TDP-43 proteinopathies with miRNA-engineered neural exosomes Orientador	Neurociências (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2017/03/01 - Atual	Studying the impact of Glia-derived extracellular vesicles on motor neuron degeneration and their modulation for a neuroprotective approach, using 2D-and 3D-cell culture model Coorientador de Marta Barbosa	Farmácia - Biologia Celular e Molecular (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/12 - 2025/01	Avanços na dinâmica epidemiológica da Doença de Alzheimer e na identificação de biomarcadores Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09/01 - 2024/12	Therapeutic Potential of miRNA-loaded Exosomes in Alzheimer’s Disease Coorientador	Biopharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09/01 - 2024/11/30	Age-Dependent Microglia Inflammatory Profile in the Spinal Cord of the ALS mSOD1G93A Mice Orientador	Pharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11 - 2024/11	Age-Dependent Microglia Inflammatory Profile in the Spinal Cord of the ALS mSOD1G93A Mice Orientador	Ciências Farmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/01 - 2024/05	Cell-free-based therapies for miRNA modulation in ALS-associated TDP-43 proteinopathy using mouse and human models Orientador	Pharmacy - Molecular and Cellular Biology (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/09/01 - 2023/12/19	Comparative Efficacy of CK1 Inhibitors and miRNA-loaded Exosomes on the Recovery of ALS Injured Microglia Orientador	Biopharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/05/01 - 2022/12/12	Evaluation of promising miRNA modulation in neural cells and derived secretomes as therapeutic tools in ALS Coorientador	Pharmacy - Molecular and Cellular Biology (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09/01 - 2022/11/25	Therapeutic potential of intrathecal application of miR-124-based secretome in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Coorientador	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2021/09/01 - 2022/11/18	Evaluation of Neuron-glia network signals using 2D/3D platforms and ALS experimental models Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - 2022/06	Unveiling aberrancies and neurotoxic properties of ALS astrocytes using unspecific and microglia-specific activation models Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/01 - 2022/03/16	Modulation of miRNA Expression in ALS Microglia Coorientador	Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09/01 - 2022/01/20	Testing miRNA-cell based strategies to obtain therapeutic secretomes for spinal ALS Coorientador	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2020/09/01 - 2021/11	Exploring the role of MFG-E8 in Amyotrophic Lateral Sclerosis Coorientador	Ciências Farmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09/01 - 2021/05/19	Role of astrocyte activation on microglia polarization in amyotrophic lateral sclerosis (ALS) Coorientador	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/09/01 - 2021/01/13	Impact of new psychoactive substances (NPS) in neuronal and microglial function Coorientador	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2019/09/01 - 2021/01/11	Development of an exosome-based therapy by specific cell modulation of microRNAs using organotypic cultures from the ALS mice Coorientador	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/09/01 - 2018/11/13	Targeting miR-124 in motor neurons as a therapeutic strategy to prevent neurodegeneration and glial activation in ALS Coorientador de Daniela Vizinha	CiÃªncias BiofarmacÃªuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/09/01 - 2018/10/31	Exploring A1 activation and miR-155 modulation in ALS spinal cord astrocytes Coorientador de Catarina Sequeira	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2013/10/01 - 2017/12/13	Role of glial cells as contributors to the onset and propagation of ALS disease Coorientador de Carolina Cunha	Farmácia - Biologia Celular e Molecular (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/09/01 - 2017/12/10	Evaluation and regulation of neuroinflammation via microglia-derived extracellular vesicles and associated DAMPs/miRNAs Coorientador de Catarina Ezequiel	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/09/01 - 2016/11/12	ALS pathogenesis: role of motor-neuron derived exosomes in microglia activation and dysfunction Coorientador de Sara Pinto	CiÃªncias BiofarmacÃªuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/09/01 - 2016/10/31	Modulation of HMGB1in reactive and irresponsive microglia treated with amyloid-ß peptide Coorientador de Maria Nunes	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2013/09/01 - 2014/11/30	The microglial-motoneuron (MN) dialogue in ALS: studies in the G93A-SOD1- mice model Coorientador de Catarina Santos	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2013/09/01 - 2014/11/30	The microglial-motoneuron (MN) dialogue in ALS: in vitro studies Coorientador de Maria Inês Cunha	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2013/10/01 - 2014/08/01	Differential effects of bilirubin on the microglia activation using maturating and aging cells: cell viability and gene expression Coorientador de Carlotta Semproni	Università degli Studi di Bologna Dipartimento di Farmacia e Biotecnologie, Itália
2012/09/01 - 2013/11/30	Dissecting cross-talk between microglia and motoneurons in ALS: an immunohistochemistry (IHC) and signaling directed study Coorientador de Marta Barbosa	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2012/09/01 - 2013/11/30	Dissecting cross-talk between microglia and motoneurons in ALS: an immunoreactive study Coorientador de Andreia Ferreira	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2011/09/01 - 2012/11/30	Exploring microglia reactivity and neuroprotective or neurotoxic properties in ALS in vitro models Coorientador de Carolina Cunha	Genética Molecular e Biomedicina (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/12	Hericium Erinaceus polyphenols on the strive against Alzheimer’s Disease Arguente	Leonor Maria Granadas Alves (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/07	The Microbiome-Gut-Brain Axis and its influence on neurodegenerative diseases: focus on Alzheimer’s Disease Arguente principal	Denise Ettenberger (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/07	New advances in treatment of Alzheimer’s disease Arguente principal	Helena Maci Cammarata (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/05	Mesenchymal stem cell secretome: a novel therapeutic opportunity to rescue COVID-19-induced neurodegeneration Arguente principal	Catarina Mendes Trigo (Outro) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	The effect of cyanotoxins on genetic mutations in amyotrophic lateral sclerosis Arguente	Sara Roque dos Santos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/09	Role of microglia in synapse pruning during Multiple Sclerosis. Arguente principal	Tomás Pereira Concha de Almeida (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07/13	Strategies for the modulation of the cargo of exosomes derived from mesenchymal stem cells Arguente principal	Inês Toste Simões (Mestrado) Universidade de Lisboa, Instituto Superior Técnico, Portugal
2022/07	Alterações Hematológicas das doenças autoimunes Arguente	Rita Estevão Correia. (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/05	Signaling Pathways and Players Activated upon Neuronal Mitochondrial Dysfunction and Involved in Antioxidant Response – Specific Role of PGC-1a Isoforms. Arguente	Susana Gomes dos Santos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/02/15	Dissecting miRNA-194-5p's and MEF2C's roles in breast cancer brain metastases Arguente	Sara Caetano (Mestrado) iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa, Portugal
2021/11	Effects of newly detected syntethic cathinones on the central nervous system Arguente	Ana Margarida Leitão (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/11	Role of Astrocytes in Neurodegeneration Arguente principal	Maria Beatriz Castela (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/11	Exploring the role of MFG-E8 in Amyotrophic Lateral Sclerosis Orientador	Helena Coutinho (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09	The impact of adult neurogenesis in mood disorders Arguente principal	Mafalda Ferreira dos Santos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09	Distúrbios neurológicos associados às novas substâncias psicotrópicas. Arguente principal	Alexandre Aleixo Marques (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/06	Doenças Neurodegenerativas: Uma Visão Gliocêntrica Arguente principal	Ana Catarina Carvalho (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/04	HMGB1 and HMGB2 interactomes in ovarian and prostate tumours. Arguente	María Cámara Quílez (Doutoramento) Universidade da Coruña, Espanha
2021/03	Avaliação do papel dos vários tipos de células do SNC na lesão de isquemia-reperfusão associado ao AVC Arguente	Sofia Santos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/13	Impact of emergent new psychoactive substances (NPS) on neuronal and microglial function. Orientador	Paulo Faria (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal
2020/12	Possibilidades terapêuticas dos polifenóis alimentares na doença de Alzheimer Arguente principal	João Nogueira (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11	Biological and Technical Advances in Therapies for Amyotrophic Lateral Sclerosis Arguente principal	Diogo Pacheco (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11	O papel das células de glia nas doenças neurodegenerativas Arguente principal	Joana Branco (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/12/19	The effect of exercise and tumor necrosis factor inhibitor on peripheral and axial inflammation in an animal model of spondyloarthritis Arguente	Ana Rita Sofio (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/02/25	Unveilling the interplay between activated astrocytes and neurons in an in vitro model of Alzheimer’s disease Arguente	Filipa Moreira (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/12/10	Circulating microRNAs as biomarkers for breast cancer brain metastasis Arguente	Marta Sereno (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/11	Targeting miR-124 in motor neurons as a therapeutic strategy to prevent neurodegeneration and glial activation in ALS Orientador	Daniela Vizinha (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09	The role of beclin-1 deacetylation on autophagic flux in Alzheimer’s disease Arguente	Filipa Filipe (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/05	Exploring the effect of NLRP3 inflammasome inhibition in the ex vivo model of epileptogenesis Arguente principal	Nuno Rosa (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2017/01	Drug delivery to the brain: design of peptides for selective blood-brain barrier transmigration Arguente principal	Sara Coelho (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2016/10	Modulation of HMGB1in reactive and irresponsive microglia treated with amyloid-ß peptide Orientador	Maria Nunes (Mestrado) Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2019/06/03 - Atual	Brain Sciences
2021/06/01 - 2022/04	Research Topic Neurodegeneration, Cell signaling and Neuroreparative Strategies	Frontiers

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2022/01/01 - Atual	Biochemistry I, Integrated Master in Pharmaceutical Sciences, FFUL	Ciências Biofarmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09 - Atual	Brain Barriers in Drug Development, Master in Biopharmaceutical Sciences, FFUL	Ciências Biofarmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/07/01 - Atual	Advances in Neuropharmaceutics Course, 1st year of the PhD in Pharmacy, FFUL Course Organizer and participation in Group discussion meetings and the final workshop ¿ Scientific projects pitch presentation. Lecturer of the Workshop: Advanced in vitro models for target discovery and neuropharmaceutic screening assays.	Advances in Neuropharmaceutics Course (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09/15 - Atual	Human Anatomy Subject, 1st year of the Integrated Master in Pharmaceutical Sciences, FFUL	Anatomia Humana (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09/15 - Atual	Development and Organization of the Nervous System, Master in Biopharmaceutical Sciences, FFUL	Organization of the Nervous System (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09/15 - Atual	Neuropathology and Neuropharmacology, Master in Biopharmaceutical Sciences, FFUL	Neuropathology and Neuropharmacology (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/01 - Atual	Pathophysiology of Neuroinflammation, Master in Biopharmaceutical Sciences, FFUL	Ciências Biofarmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2024/02 - Atual	Sociedade Portuguesa de Farmacologia	member
2017 - Atual	Portuguese Anatomical Society
2008 - Atual	Portuguese Society for Neurosciences

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2020/03/01 - 2020/03/30	Member of the jury to select the candidates that applied for a position of junior researcher for PhD holders under the project PTDC/SAU-TOX/32515/2017 (FCT - New psychoactive substances – a platform for risk assessment of teens brain exposure. PI: Á Lopes).	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/12/15 - 2019/01/31	Member of the jury to select the candidates that applied for a position of research fellowship for MSc holders under the project - PTDC/MED-ONC/29402/2017 (FCT- Detect, prevent, eradicate: a multi-step strategy to abrogate brain metastasization of breast cancer. PI: MA Brito).	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/11/01 - 2018/12/19	Member of the jury to select the candidates that applied for a position of junior researcher for PhD holders under the project PTDC/MED-NEU/31395/2017 (FCT - Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis (ALS). PI: D Brites; Co-PI: AR Vaz).	Universidade de Lisboa Faculdade de Farmácia, Portugal

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2019/10 - Atual	Frontiers in Cellular Neuroscience (1662-5102)	Frontiers Media SA
2019/05 - Atual	Cellular & Molecular Biology Letters (1689-1392)	Springer (Biomed Central Ltd.)
2019/04 - Atual	Gene (0378-1119)	Elsevier
2018/09 - Atual	Neurotoxicity Research (1476-3524)	Springer-Verlag
2018/06 - Atual	Journal of Neuroinflammation (1742-2094)	Springer (Biomed Central Ltd.)
2017/07 - Atual	Journal of Neurochemistry (1471-4159)	Wiley (Blackwell Publishing)

Distinções

Prémio

2014	Best Poster Presentation at I Luso-Brasilian Glial Network Symposium

Outra distinção

2019	Fellowship for participation at SPN Meeting 2019, Lisbon, May 30- Jun 1, 2019 Sociedade Portuguesa de Neurociências, Portugal
2017	Fellowship for participation in the European Meeting on Glial Cells in Health and Disease in Edinburgh, UK, July 8 – 11, 2017 Network GLIA, Alemanha
2013	Fellowship for participation at 24th Biennial Meeting ISN/ASN 2013, Cancun, Mexico, April 20-24, 2013 International Society for Neurochemistry, Suiça
2013	Fellowship for participation at 13th ESNI 2013 Course, Porto, Portugal, July 3-6, 2013 European School of neuroimmunology, Itália
2012	Fellowship for participation at 8th FENS Forum of European Neuroscience, Barcelona, Spain, July 14-18, 2012 Sociedade Portuguesa de Neurociências, Portugal