???global.info.a_carregar???
• PhD in Biochemistry (2011) with +15 experience in life sciences and biotechnology. • Expertise in molecular biology, microbiology, recombinant protein biochemistry and structural biology. • Extensive experience in biopharmaceutical production processes combined with knowledge of regulatory/quality requirements. • Skilled in ideation, technology assessment and valorisation in pharma and biotech sectors. • Experience in working directly with academia and industry experts as part of collaborative and contract research.
Identificação

Identificação pessoal

Nome completo
Rita Mafalda dos Santos Rocha do Rosário

Nomes de citação

  • Rocha, Rita

Identificadores de autor

Ciência ID
0D18-5B08-2B80
ORCID iD
0000-0003-1193-8320

Endereços de correio eletrónico

  • rita.rocha@nms.unl.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
Formação
Grau Classificação
2011
Concluído
 Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Structural impact of ambiguous CUG decoding in Candida albicans" (TESE/DISSERTAÇÃO)
 Aprovada com distinção e louvor - approved
2003
Concluído
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
 15 (0-20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/07/01 - Atual Gestão de Ciência e Tecnologia Universidade NOVA de Lisboa NOVA Medical School, Portugal
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2015/12/01 - 2022/06/30 Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020 - 2021 Gestão de Ciência e Tecnologia YourBiome Therapeutics, Portugal
2011 - 2015 Pós-doutorado (Investigação) Universidade do Porto Faculdade de Medicina, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013 - 2020 Professor Adjunto Convidado (Docente Ensino Superior Politécnico) Escola Superior Saúde Santa Maria, Portugal
Projetos

Bolsa

Designação Financiadores
2015 - Atual Structural and functional characterization of K+ transport in bacteria
SFRH/BPD/111525/2015
Bolseiro de Pós-Doutoramento
Em curso
2011 - 2015 Unveiling the molecular basis of the echinocandins resistance - the first-line antifungals
Pfizer, Inc (USA) | WS814116.
Bolseiro de Pós-Doutoramento
2013 - 2013 ASPIRE - Translational research project for development of a novel protein affinity tag
IBMC
Investigador responsável
2005 - 2010 Determination of the 3D-structure of the translational factors that mediate a genetic code change in Candida albicans
SFRH/BD/15233/2004
Bolseiro de Doutoramento

Projeto

Designação Financiadores
2018/07/26 - 2022/07/25 Characterization of the molecular properties of the K+ homeostasis machinery in a bacterium
PTDC/BIA-BQM/29863/2017
Investigador responsável
Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017 - 2021 Bacterial K+ transporters are potential antimicrobial targets: mechanisms of transport and regulation
FLAD LIFE SCIENCE 2020
Investigador Pós-doutorado
2011 - 2015 Unveiling the molecular basis of echinocandins resistance - the first-line antifungals.
WS814116
Investigador Pós-doutorado
Universidade do Porto Faculdade de Medicina, Portugal
 Pfizer Inc
Concluído
2011 - 2012 Clinical efficacy of a novel technology for microbial load decontamination in hospital intensive care units
ASP - Johnson & Johnson, Inc.|Tracking number: 11-ASP-001
Investigador
2010 - 2011 In vitro effect of antifungal combinations against Candida species
Pfizer Tracking Number WS718413
Investigador
2010 - 2011 QUITORAL: development of new prototypes with applications on oral medicine having chitosan as antimicrobial agent
QREN-ADI Project 3474
Investigador
2005/07/01 - 2008/12/30 Molecular study of the virulence mechanism of Candida albicans
POCI/SAU-IMI/61598/2004
Investigador
Universidade do Porto Faculdade de Medicina, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/06/01 - 2008/05/31 Determination of the 3D-structure of the translational factors that mediate a genetic code change in Candida albicans.
POCI/BIA-PRO/55472/2004
Investigador
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005/02/01 - 2008/04/30 Understanding morphogenesis and sexual reproduction induced by an alteration to the genetic code in Candida albicans
POCI/BIA-MIC/55466/2004
Investigador
Universidade de Aveiro, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Rocha, R.; Morais-Cabral, J. H.; Pina-Vaz, C.. "Insights into the synthesis of beta-1,3-glucan in Candida albicans: relevance for echinocandins inhibition". Trabalho apresentado em 7th Trends in Medical Mycology, Lisbon, 2015.
Artigo em revista
  1. Rodrigues, Tânia; Rodrigues Fialho, Sofia; Araújo, João Ricardo; Rocha, Rita; Moreira-Rosário, André. "Procedures in Fecal Microbiota Transplantation for Treating Irritable Bowel Syndrome: Systematic Review and Meta-Analysis". Journal of Clinical Medicine 12 5 (2023): 1725. http://dx.doi.org/10.3390/jcm12051725.
    10.3390/jcm12051725
  2. Moreira-Rosário, André; Marques, Cláudia; Pinheiro, Hélder; Araújo, João Ricardo; Ribeiro, Pedro; Rocha, Rita; Mota, Inês; et al. "Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.705020.
    10.3389/fmicb.2021.705020
  3. Rocha, Rita; Teixeira-Duarte, Celso M.; Jorge, João M.P.; Morais-Cabral, João Henrique. "Characterization of the molecular properties of KtrC, a second RCK domain that regulates a Ktr channel in Bacillus subtilis". Journal of Structural Biology 205 3 (2019): 34-43. http://dx.doi.org/10.1016/j.jsb.2019.02.002.
    10.1016/j.jsb.2019.02.002
  4. Szollosi, Andras; Vieira-Pires, Ricardo S.; Teixeira-Duarte, Celso M.; Rocha, Rita; Morais-Cabral, João H.. "Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter". PLOS Biology 14 1 (2016): e1002356. http://dx.doi.org/10.1371/journal.pbio.1002356.
    10.1371/journal.pbio.1002356
  5. Espinar, Maria José; Miranda, Isabel M.; Costa-de-Oliveira, Sofia; Rocha, Rita; Rodrigues, Acácio G.; Pina-Vaz, Cidália. "Urinary Tract Infections in Kidney Transplant Patients Due to Escherichia coli and Klebsiella pneumoniae-Producing Extended-Spectrum ß-Lactamases: Risk Factors and Molecular Epidemiology". PLOS ONE 10 8 (2015): e0134737. http://dx.doi.org/10.1371/journal.pone.0134737.
    10.1371/journal.pone.0134737
  6. Noites, Rita; Pina-Vaz, Cidália; Rocha, Rita; Carvalho, Manuel Fontes; Gonçalves, Acácio; Pina-vaz, Irene. "Synergistic Antimicrobial Action of Chlorhexidine and Ozone in Endodontic Treatment". BioMed Research International 2014 (2014): 1-6. http://dx.doi.org/10.1155/2014/592423.
    10.1155/2014/592423
  7. Miranda, Isabel; Silva-Dias, Ana; Rocha, Rita; Teixeira-Santos, Rita; Coelho, Carolina; Gonçalves, Teresa; Santos, Manuel A. S.; et al. "Candida albicans CUG Mistranslation Is a Mechanism To Create Cell Surface Variation". mBio 4 4 (2013): http://dx.doi.org/10.1128/mbio.00285-13.
    10.1128/mbio.00285-13
  8. Faria-Ramos, I.; Espinar, M.J.; Rocha, R.; Santos-Antunes, J.; Rodrigues, A.G.; Cantón, R.; Pina-Vaz, C.. "A novel flow cytometric assay for rapid detection of extended-spectrum beta-lactamases". Clinical Microbiology and Infection 19 1 (2013): E8-E15. http://dx.doi.org/10.1111/j.1469-0691.2012.03986.x.
    10.1111/j.1469-0691.2012.03986.x
  9. Teixeira-Santos, R.; Rocha, R.; Moreira-Rosário, A.; Monteiro-Soares, M.; Cantón, E.; Rodrigues, A.G.; Pina-Vaz, C.. "Novel method for evaluating in vitro activity of anidulafungin in combination with amphotericin B or azoles". Journal of Clinical Microbiology 50 8 (2012): 2748-2754. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864399944&partnerID=MN8TOARS.
    10.1128/JCM.00610-12
  10. Silva-Dias, A.; Miranda, I.M.; Rocha, R.; Monteiro-Soares, M.; Salvador, A.; Rodrigues, A.G.; Pina-Vaz, C.. "A novel flow cytometric protocol for assessment of yeast cell adhesion". Cytometry Part A 81 A 3 (2012): 265-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857373442&partnerID=MN8TOARS.
    10.1002/cyto.a.21170
  11. Rocha, R.; Barbosa Pereira, P.J.; Santos, M.A.S.; MacEdo-Ribeiro, S.. "Purification, crystallization and preliminary X-ray diffraction analysis of the seryl-tRNA synthetase from Candida albicans". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 1 (2011): 153-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651065708&partnerID=MN8TOARS.
    10.1107/S1744309110048542
  12. Espinar, M.J.; Rocha, R.; Ribeiro, M.; Rodrigues, A.G.; Pina-Vaz, C.. "Extended-spectrum ß-lactamases of Escherichia coli and Klebsiella pneumoniae screened by the VITEK 2 system". Journal of Medical Microbiology 60 6 (2011): 756-760. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957590706&partnerID=MN8TOARS.
    10.1099/jmm.0.024075-0
  13. Rocha, R.; Pereira, P.J.B.; Santos, M.A.S.; Macedo-Ribeiro, S.. "Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen". Proceedings of the National Academy of Sciences of the United States of America 108 34 (2011): 14091-14096. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052182956&partnerID=MN8TOARS.
    10.1073/pnas.1102835108
  14. Silva, A.P.; Miranda, I.M.; Guida, A.; Synnott, J.; Rocha, R.; Silva, R.; Amorim, A.; et al. "Transcriptional profiling of azole-resistant Candida parapsilosis strains". Antimicrobial Agents and Chemotherapy 55 7 (2011): 3546-3556. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959214576&partnerID=MN8TOARS.
    10.1128/AAC.01127-10
  15. Costa-de-Oliveira, S.; Miranda, I.M.; Silva, R.M.; E Silva, A.P.; Rocha, R.; Amorim, A.; Rodrigues, A.G.; Pina-Vaz, C.. "FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy". Antimicrobial Agents and Chemotherapy 55 3 (2011): 1312-1314. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952357849&partnerID=MN8TOARS.
    10.1128/AAC.00589-10
  16. Miranda, I.; Rocha, R.; Santos, M.C.; Mateus, D.D.; Moura, G.R.; Carreto, L.; Santos, M.A.S.. "A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans". PLoS ONE 2 10 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-39149117967&partnerID=MN8TOARS.
    10.1371/journal.pone.0000996
  17. Silva, R.M.; Paredes, J.A.; Moura, G.R.; Manadas, B.; Lima-Costa, T.; Rocha, R.; Miranda, I.; et al. "Critical roles for a genetic code alteration in the evolution of the genus Candida". EMBO Journal 26 21 (2007): 4555-4565. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648984625&partnerID=MN8TOARS.
    10.1038/sj.emboj.7601876
Poster em conferência
  1. Jorge, João M. P.; Rocha, Rita; Teixeira-Duarte, C. M.; Morais-Cabral, João. "In vivo study of the physiological role of Bacillus subtilis potassium importers". Trabalho apresentado em Bacterial Networks, 2019.
  2. Laranjeira, João; Cruz, Rui; Vilaça, Rita; Mendes, Marta V.; Rocha, Rita; Vieira-Pires, Ricardo S.. "Immunotargeting of E.coli TolC outer membrane channel". Trabalho apresentado em 5th International Iberian Biophysics Congress, 15-17th June 2016, Porto, Portugal, 2016.
Pré-impressão
  1. Rocha, Rita; Jorge, João M. P.; Texeira-Duarte, Celso M.; Figueiredo-Costa, Inês R.; Herzberg, Christina; Stülke, Jörg; Morais-Cabral, João H.. "c-di-AMP determines the hierarchical organization of bacterial RCK proteins". 2023. http://dx.doi.org/10.1101/2023.04.24.538052.
    10.1101/2023.04.24.538052

Propriedade Intelectual

Patente
  1. 2017. "Kit and method of detecting the resistant microorganisms to a therapeutic agent".
    Concedida/Emitida
Distinções

Prémio

2007 Best innovation project in food biotechnology
2007 Best poster presentation in the international