Identificação pessoal

Nome completo

Joseph Paton

Nomes de citação

• Paton, Joseph

Identificadores de autor

Ciência ID

0C10-BB79-908D

ORCID iD

0000-0002-1663-6455

Websites

• https://patonlab.org/ (Profissional)

Domínios de atuação

• Ciências Naturais - Ciências Biológicas

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Português	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B1)	Utilizador independente (B2)

	Grau	Classificação
2008 Concluído	Columbia University Doctoral program in Neurobiology and Behavior (Doctor of Philosophy) Columbia University, Estados Unidos " Neural activity in the primate amygdala during appetitive and aversive classical conditioning" (TESE/DISSERTAÇÃO)	Thesis awarded with distinction
2003 Concluído	Columbia University Doctoral program in Neurobiology and Behavior (Master) Columbia University, Estados Unidos "N/A" (TESE/DISSERTAÇÃO)	N/A
2000 Concluído	Bachelor of Science in Biology (Bachelor) Tufts University, Estados Unidos "The effect of Pilocarpine on a motor rhythm in larval Manduca Sexta" (TESE/DISSERTAÇÃO)	Highest Thesis Honors

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2012/01/01 - Atual	Investigador principal (carreira) (Investigação)	Programa Champalimaud de Neurociências, Portugal
2008/05/01 - 2012/01/31	Investigador (Investigação)	Fundação Champalimaud, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2019/11/30 - Atual	Director de Unidade Orgânica	Fundação Champalimaud, Portugal
	Programa Champalimaud de Neurociências, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2008/05/01 - 2012/01/31	Visiting Scientist	Howard Hughes Medical Institute Janelia Farm Research Campus, Estados Unidos
2002/09/02 - 2008/05/14	Doctoral student in the laboratory of Dr. Daniel Salzman	Columbia University, Estados Unidos
2001/09/01 - 2002/09/01	Research Technician, Laboratory of Dr. Daniel Salzman	Columbia University, Estados Unidos
2000/08/20 - 2001/08/15	Research Technician in the laboratory of Dr. William T. Newsome	Howard Hughes Medical Institute - Stanford University, Estados Unidos
1998/09/01 - 2000/05/15	Undergraduate researcher within the invertebrate neurobiology laboratory of Dr. Barry Trimmer	Tufts University, Estados Unidos
1999/05/15 - 1999/09/01	Howard Hughes Medical Institute summer student, Worked in the Development/Genetics laboratory of Dr. Alan Michelson.	Howard Hughes Medical Institute - Harvard Medical School, Estados Unidos
1997/05/15 - 1997/09/01	Course assistant for summer graduate courses in Parasitology, Medical Mycology, and Computational Neuroscience	Marine Biological Laboratory, Estados Unidos

Bolsa

	Designação	Financiadores
2023/09/01 - 2025/08/31	Differential targeting of molecularly identified striatal neurons as a therapeutic strategy for minimizing non-motor side effects of dopamine replacement MJFF-023180 Investigador responsável Fundação Champalimaud, Portugal	Michael J. Fox Foundation (MJFF) Em curso
2018 - 2023	Toward a circuit level understanding of cognition 55008745 Investigador responsável	Howard Hughes Medical Institute Em curso
2018 - 2023	Basal ganglia circuit mechanisms underlying dynamic cognitive behavior DYCOCIRC_772339 Investigador responsável	European Research Council Em curso
2017 - 2020	How do dopamine neurons and striatal populations interact during decision-making? 193/2016 Investigador responsável	Fundação Bial Concluído
2014/03/01 - 2017/02/28	How do the basal ganglia force cortex to do what they want? SCGB 325476 Investigador responsável	Simons Foundation Concluído
2013/01/01 - 2015/12/31	Embodied Cognition, the nature of time encoding in the brain? BIAL-BIC-188/12 Investigador responsável	Fundação Bial Concluído

Projeto

	Designação	Financiadores
2022/01/17 - 2025/01/16	The neural basis of Weber´s Law PTDC/MED-NEU/4584/2021 Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/17 - 2022/01/16	Whole-brain mechanisms of operant learning in zebrafish: cells, circuits and behaviour. PTDC/MED-NEU/32664/2017 Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/01/01 - 2019/12/31	Champalimaud Neuroscience Programme UID/NEU/04443/2019 Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2017 - 2018	Pharmacological and circuit dissection of direct and indirect pathways during impulsivity research agreement Investigador responsável	Roche Pharma Schweiz AG Concluído

Publicações

Artigo em revista	Rodrigues, Filipe S.; Monteiro, Tiago; Motiwala, Asma; Paton, Joseph J.. "The dorsolateral striatum encodes a temporal basis for the organization of behavior". Neuron 112 22 (2024): 3675-3677. https://doi.org/10.1016/j.neuron.2024.10.022. 10.1016/j.neuron.2024.10.022 Tiago Monteiro; Filipe S. Rodrigues; Margarida Pexirra; Bruno F. Cruz; Ana I. Gonçalves; Pavel E. Rueda-Orozco; Joseph J. Paton. "Using temperature to analyze the neural basis of a time-based decision". Nature Neuroscience (2023): https://doi.org/10.1038/s41593-023-01378-5. 10.1038/s41593-023-01378-5 Bruno F. Cruz; Gonçalo Guiomar; Sofia Soares; Asma Motiwala; Christian K. Machens; Joseph J. Paton. "Action suppression reveals opponent parallel control via striatal circuits". Nature (2022): https://doi.org/10.1038/s41586-022-04894-9. 10.1038/s41586-022-04894-9 Asma Motiwala; Sofia Soares; Bassam V. Atallah; Joseph J. Paton; Christian K. Machens. "Efficient coding of cognitive variables underlies dopamine response and choice behavior". Nature Neuroscience (2022): https://doi.org/10.1038/s41593-022-01085-7. 10.1038/s41593-022-01085-7 Cruz BF; Paton JJ. "Dopamine gives credit where credit is due.". Neuron (2021): http://europepmc.org/abstract/med/34139181. 10.1016/j.neuron.2021.05.033 Paton, Joseph J.; Buonomano, Dean V.. "The Neural Basis of Timing: Distributed Mechanisms for Diverse Functions". Neuron 98 4 (2018): 687-705. http://dx.doi.org/10.1016/j.neuron.2018.03.045. 10.1016/j.neuron.2018.03.045 Lau, Brian; Monteiro, Tiago; Paton, Joseph J. "The many worlds hypothesis of dopamine prediction error: implications of a parallel circuit architecture in the basal ganglia". Current Opinion in Neurobiology 46 (2017): 241-247. http://dx.doi.org/10.1016/j.conb.2017.08.015. 10.1016/j.conb.2017.08.015 Burgess, Christopher P.; Lak, Armin; Steinmetz, Nicholas A.; Zatka-Haas, Peter; Bai Reddy, Charu; Jacobs, Elina A.K.; Linden, Jennifer F.; et al. "High-Yield Methods for Accurate Two-Alternative Visual Psychophysics in Head-Fixed Mice". Cell Reports 20 10 (2017): 2513-2524. http://dx.doi.org/10.1016/j.celrep.2017.08.047. 10.1016/j.celrep.2017.08.047 Saez, Rebecca A.; Saez, Alexandre; Paton, Joseph J.; Lau, Brian; Salzman, C. Daniel. "Distinct Roles for the Amygdala and Orbitofrontal Cortex in Representing the Relative Amount of Expected Reward". Neuron 95 1 (2017): 70-77.e3. http://dx.doi.org/10.1016/j.neuron.2017.06.012. 10.1016/j.neuron.2017.06.012 Soares S; Atallah BV; Paton JJ. "Midbrain dopamine neurons control judgment of time.". (2016): http://europepmc.org/abstract/med/27940870. Gouvêa, Thiago S; Monteiro, Tiago; Motiwala, Asma; Soares, Sofia; Machens, Christian; Paton, Joseph J. "Striatal dynamics explain duration judgments". eLife 4 (2015): http://dx.doi.org/10.7554/elife.11386. 10.7554/elife.11386 Mello GB; Soares S; Paton JJ. "A scalable population code for time in the striatum.". (2015): http://europepmc.org/abstract/med/25913405. 10.1016/j.cub.2015.02.036 Paton JJ; Lau B. "Tread softly and carry a clock's tick.". (2015): http://europepmc.org/abstract/med/25710833. 10.1038/nn.3959 Lopes G; Bonacchi N; Frazão J; Neto JP; Atallah BV; Soares S; Moreira L; et al. "Bonsai: an event-based framework for processing and controlling data streams.". (2015): http://europepmc.org/abstract/med/25904861. 10.3389/fninf.2015.00007 Gomez-Marin, A.; Paton, J.J.; Kampff, A.R.; Costa, R.M.; Mainen, Z.F.. "Big behavioral data: Psychology, ethology and the foundations of neuroscience". Nature Neuroscience 17 11 (2014): 1455-1462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908500040&partnerID=MN8TOARS. 10.1038/nn.3812 Gouvêa, T.S.; Monteiro, T.; Soares, S.; Atallah, B.V.; Paton, J.J.. "Ongoing behavior predicts perceptual report of interval duration". Frontiers in Neurorobotics 8 MAR (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84904858499&partnerID=MN8TOARS. 10.3389/fnbot.2014.00010 Zhang, W.; Schneider, D.M.; Belova, M.A.; Morrison, S.E.; Paton, J.J.; Salzman, C.D.. "Functional circuits and anatomical distribution of response properties in the primate amygdala". Journal of Neuroscience 33 2 (2013): 722-733. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872062763&partnerID=MN8TOARS. 10.1523/JNEUROSCI.2970-12.2013 Paton, J.J.; Louie, K.. "Reward and punishment illuminated". Nature Neuroscience 15 6 (2012): 807-809. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861537988&partnerID=MN8TOARS. 10.1038/nn.3122 Belova, M.A.; Paton, J.J.; Salzman, C.D.. "Moment-to-moment tracking of state value in the amygdala". Journal of Neuroscience 28 40 (2008): 10023-10030. http://www.scopus.com/inward/record.url?eid=2-s2.0-54049104420&partnerID=MN8TOARS. 10.1523/JNEUROSCI.1400-08.2008 Belova, M.A.; Paton, J.J.; Morrison, S.E.; Salzman, C.D.. "Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala". Neuron 55 6 (2007): 970-984. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548571904&partnerID=MN8TOARS. 10.1016/j.neuron.2007.08.004 Salzman, C.D.; Paton, J.J.; Belova, M.A.; Morrison, S.E.. "Flexible neural representations of value in the primate brain". Annals of the New York Academy of Sciences 1121 (2007): 336-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549052420&partnerID=MN8TOARS. 10.1196/annals.1401.034 Paton, J.J.; Belova, M.A.; Morrison, S.E.; Salzman, C.D.. "The primate amygdala represents the positive and negative value of visual stimuli during learning". Nature 439 7078 (2006): 865-870. http://www.scopus.com/inward/record.url?eid=2-s2.0-32844469435&partnerID=MN8TOARS. 10.1038/nature04490 Salzman, C.D.; Belova, M.A.; Paton, J.J.. "Beetles, boxes and brain cells: Neural mechanisms underlying valuation and learning". Current Opinion in Neurobiology 15 6 (2005): 721-729. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944492732&partnerID=MN8TOARS. 10.1016/j.conb.2005.10.016
Poster em conferência	Sousa Margarida; Bujalski, Pawel; Cruz Bruno; Louie Kenway ; McNamee, Daniel; Paton, Joseph. "Dopamine neurons reveal an efficient code for a multidimensional, distributional map of the future.". Trabalho apresentado em COSYNE, 2023 (Montreal, Canada), 2023. Freitas, Sofia; Paton, Joseph; Renart, Alfonso. Autor correspondente: Freitas, Sofia. "Probing the mechanistic implementation of temporal control using behaviour". Trabalho apresentado em 2021 Champalimaud Research Symposium - Dialogues on neural and machine intelligence, 2021.
Pré-impressão	Haimerl, Caroline; Filipe S. Rodrigues; Paton, Joseph. Autor correspondente: Paton, Joseph. "Time, control, and the nervous system". 2025. https://arxiv.org/abs/2503.22917. Sousa, Margarida; Bujalski, Pawel; Cruz, Bruno F.; Louie, Kenway; McNamee, Daniel; Paton, Joseph J.. "Dopamine neurons encode a multidimensional probabilistic map of future reward". 2023. http://dx.doi.org/10.1101/2023.11.12.566727. 10.1101/2023.11.12.566727 Filipe S. Rodrigues; Tiago Monteiro; Asma Motiwala; Joseph J. Paton. "The dorsolateral striatum encodes a temporal basis for the organization of behavior". 2023. https://doi.org/10.1101/2023.11.13.566826. 10.1101/2023.11.13.566826 Thiago S. Gouvêa; Tiago Monteiro; Asma Motiwala; Sofia Soares; Christian K. Machens; Joseph J. Paton. "Striatal dynamics explain duration judgments". 2015. https://doi.org/10.1101/020883. 10.1101/020883
Tese / Dissertação	Cruz, Bruno. "Striatal circuits supporting action production and suppression". Doutoramento, 2022. http://hdl.handle.net/10362/138597. Soares, Sofia Lima da Silva. "Time in the basal ganglia". Doutoramento, 2017. http://hdl.handle.net/10362/78875. Gouvêa, Thiago Santos. "Striatal dynamics represent subjective time". Doutoramento, 2016. http://hdl.handle.net/10362/51884. Peixoto, Diogo Manuel Barros Magalhães da Rocha. "Single-trial correlates of decision-making in dorsal premotor and primary motor cortices". Doutoramento, 2016. http://hdl.handle.net/10362/55748. Mello, Gustavo Borges Moreno e. "Neural and Behavioral Mechanisms of Interval Timing in the Striatum". Doutoramento, 2016. http://hdl.handle.net/10362/43665. Lopes, Gonçalo Cardoso. "A Robust Role for Motor Cortex". Doutoramento, 2016. http://hdl.handle.net/10362/57508. Fernandes, José Joaquim Fonseca Ribas. "Hierarchical Reinforcement Learning in Behavior and the Brain". Doutoramento, 2013. http://hdl.handle.net/10362/11971. Soares, Sofia Lima da Silva, 1987-. "Optogenetic investigation of striatal cell type during timing behavior". Mestrado, 2010. http://hdl.handle.net/10451/2392.

Outros

Outra produção

Using temperature to analyse the neural basis of a latent temporal decision. In revision. 2020. Tiago Monteiro; Filipe S. Rodrigues; Margarida Pexirra; Bruno F. Cruz; Ana I. Gonçalves; Pavel E. Rueda-Orozco; Joseph J. Paton. https://doi.org/10.1101/2020.08.24.251827. 10.1101/2020.08.24.251827 Striatal circuits support broadly opponent aspects of action suppression and production. Now titled "Action suppression reveals opponent parallel control via striatal circuits" and in principle accepted for publication in Nature, 2022. Authors: Bruno F. Cruz, Gonçalo Guiomar, Asma Motiwala, Sofia Soares, Chrisitian K. Machens, Joseph J. Paton. 2020. Paton, Joseph. https://doi.org/10.1101%2F2020.06.30.180539. 10.1101/2020.06.30.180539 Dopamine responses reveal efficient coding of cognitive variables. now titled "Efficient coding of cognitive variables underlies dopamine responses and choice behavior" and in principle accepted for publication in Nature Neuroscience, 2022.. 2020. Paton, Joseph. https://doi.org/10.1101%2F2020.05.20.100065. 10.1101/2020.05.20.100065 A robust role for motor cortex. 2016. Gonçalo Lopes; Joana Nogueira; George Dimitriadis; Jorge Aurelio Menendez; Joseph J. Paton; Adam R. Kampff. https://doi.org/10.1101/058917. 10.1101/058917 High-yield methods for accurate two-alternative visual psychophysics in head-fixed mice. 2016. Christopher P Burgess; Armin Lak; Nicholas A Steinmetz; Peter Zatka-Haas; Charu Bai Reddy; Elina A K Jacobs; Jennifer F Linden; et al. https://doi.org/10.1101/051912. 10.1101/051912

Outra distinção

2017	Howard Hughes Medical Institute International Research Scholar Howard Hughes Medical Institute, Estados Unidos
2008	PhD awarded with distinction Columbia University, Estados Unidos
2000	Senior undergraduate thesis, highest honors Tufts University, Estados Unidos
1999	HHMI summer student Howard Hughes Medical Institute, Estados Unidos