Márcia Raquel Pereira de Almeida e Liz (0A18-1919-C745)

Curriculum Vitae

Márcia Raquel Pereira de Almeida e Liz

Márcia A. Liz graduated in Biochemistry from the University of Porto in 2000. Her scientific career began internationally with an internship at Sugen Company (San Francisco, CA) under the "CONTACTO" program. During her PhD (2003-2008, at IBMC-Porto, with work developed at Stanford and São Paulo Universities), Márcia unraveled transthyretin (TTR) as a novel metalloprotease, received a Gulbenkian Young Investigator Award, and published four first-author research papers (J Biol Chem, 2004; J Lipid Res, 2007; Biochem J, 2009; Biochem J, 2012), three invited reviews (Cell Mol Life Sci, 2005; FEBS J, 2010; IUBMB Life, 2010), and one book chapter. As a postdoctoral researcher (2008-2013, Nerve Regeneration Group, IBMC), she described MSC transplantation as a therapeutic option for leukodystrophies (Stem Cells 2011; Cell Transplant 2014), unraveled the impact of microtubule regulators on CNS regeneration (BMC Biol 2014), received FCT funding as PI, supervised one MSc thesis, one research fellow, two undergraduate students, and co-supervised two MSc theses. Márcia then secured an auxiliary researcher position at IBMC/i3S, supported by ON2.QREN (2013-2015), an FCT Investigator contract (2017-2022), and an FCT Institutional CEEC (April 2022-December 2024). Within this position, she started her independent research as project leader of the ND Team within the Nerve Regeneration Group, focusing on the impact of prone-to-aggregate proteins on the neuronal cytoskeleton in neurodegenerative disorders (Prog Neurobiol 2016, Front Cell Dev Biol 2020). This research program, for which she secured multiple grants as PI (ON2.QREN, FCT, Pfizer, research agreements with private companies), led to several important discoveries: 1. Unraveling mechanisms underlying TTR impact on neuronal pathophysiology (senior authorships): TTR proteolysis underlies its neuroprotective effect on Alzheimer's disease (Neurobiol Aging 2017); TTR is a regulator of neuronal microtubule dynamics (Front Cell Dev Biol 2021); Amyloidogenic TTR interacts with actin cytoskeleton regulators (Sci Rep 2020); Actin dysfunction precedes neurodegeneration in TTR amyloid polyneuropathy via dysregulation of Rac1 (bioRxiv 2025; manuscript under peer review Cell Reports). 2. Work showing that a-Synuclein induces cofilin pathology mediating hippocampal spine dysfunction in the context of Lewy Body disorders (senior author: Cell Death Dis 2024). 3. Demonstrating the impact of cytoskeleton regulators on axonal growth (co-author: JCI 2020; Front Cell Neurosci 2019). 4. Identifying novel therapeutic strategies for neurodegenerative disorders (co-author: Eur J Med Chem 2021, ACS Chem Neurosci 2021). Her research on cytoskeleton dysfunction in neurodegenerative diseases has been selected for oral communication at national and international conferences. In 2024, Márcia Liz established herself as a tenured Assistant researcher at the Unit for Multidisciplinary Research in Biomedicine (UMIB) at ICBAS, University of Porto, reinforcing her role as an independent researcher within a clinical and translational research environment. At UMIB, her research continues to focus on axonal dysfunction in neuropathies and neurodegenerative diseases, expanding her translational work with clinical collaborations. Márcia is currently supervising one junior researcher, one PhD and one MSc student, co-supervising one PhD research fellow, and, as a project leader, has previously supervised two PhD students, two postdocs, seven MSc students, five research fellows, and nine undergraduate students. She is also an active peer reviewer for international journals, participated as a grant reviewer (Parkinson's UK), and has been involved in the organization of workshops, scientific meetings, and outreach activities. Additionally, she is a lecturer in the PhD/MSc Program in Neuroscience (FMUP). Márcia Liz has published 25 papers (9 as first author, 7 as senior author), with 853 citations and an h-index of 17.

Ler resumo completo ↓

Identificação

Identificação pessoal

Nome completo: Márcia Raquel Pereira de Almeida e Liz

Nomes de citação

Liz, Márcia Almeida

Identificadores de autor

Ciência ID: 0A18-1919-C745
ORCID iD: 0000-0002-5126-663X
Researcher Id: K-4280-2013
Scopus Author Id: 22955922100

Endereços de correio eletrónico

mrliz@icbas.up.pt (Profissional)

Telefones

Telefone

220408800 Ext.: 6143 (Profissional)

Moradas

Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Formação

	Grau	Classificação
2008/03/17 Concluído	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Novel Function of Transthyretin: a Cryptic Protease Activity" (TESE/DISSERTAÇÃO)	Approved with unanimity
2000/02/26 Concluído	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2024/12/30 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2022/04/01 - 2024/12/29	Assistant Researcher- Institutional CEEC	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal (...)
2016/01/01 - 2024/12/29	Project Leader Neurodegeneration Team, Nerve Regeneration Group	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/01/01 - 2022/03/31	Assistant Researcher- FCT Investigator 2015 Starting Grant	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal (...)
2019/07/09 - 2019/07/19	Visiting Researcher	Colorado State University, Estados Unidos
	Colorado State University, Estados Unidos
2015/07/15 - 2016/12/31	Postdoctoral Fellow	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/06/01 - 2015/06/30	Junior Group Leader (at the Assistant Researcher level)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/04/01 - 2013/05/31	Postdoctoral Fellow	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2003/04/24 - 2008/03/17	PhD student	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007/03/05 - 2007/03/30	Visiting PhD student	Stanford University, Estados Unidos
	Stanford University, Estados Unidos
2007/01/29 - 2007/02/28	Visiting PhD Student	Universidade Federal de São Paulo, Brasil
	Universidade Federal de São Paulo, Brasil
2002/04/01 - 2003/04/23	Research fellow	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/02/01 - 2001/12/31	Research Intern	Sugen - Pharmacia Company, Estados Unidos
	Sugen - Pharmacia Company, Estados Unidos
2000/10/16 - 2000/12/15	Research Intern	Stab Vida Investigação e Serviços em Ciências Biológicas Lda, Portugal
	Stab Vida Investigação e Serviços em Ciências Biológicas Lda, Portugal

Projetos

Bolsa

	Designação	Financiadores
2024/01/01 - 2026/12/31	A human sensory neuron model to explore the pathophysiology of Transthyretin Amyloid Polyneuropathy ID#87074543 Co-Investigador Responsável (Co-IR)	Pfizer Inc
2022/01/01 - 2024/12/31	Dissecting unexplored mechanisms underlying Transthyretin neuroprotection and advancing towards a therapy for Alzheimer's Disease. PTDC/MED-PAT/0959/2021 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - 2023/12/31	Exploring axonal microtubule and mitochondrial transport defects in Transthyretin Amyloid Polyneuropathy (ATTR-PN) 67463999 Investigador responsável Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Pfizer Inc
2017/01/01 - 2022/03/31	Actin cytoskeleton disruption as a novel player in the pathogenesis of familial amyloid polyneuropathy: impact in the development of new therapeutic approaches IF/00902/2015 50k€ Investigador responsável Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/01 - 2021/10/30	Dissecting the actin cytoskeleton as novel therapeutic target in familial amyloid polyneuropathy. PTDC/MED-NEU/28336/2017 239k€ Investigador responsável Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/01/01 - 2019/12/31	Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease FCT/DAAD cooperation 2018/2019 Investigador responsável Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/05/01 - 2019/12/31	Dissect the relevance of cytoskeleton alterations in the pathogenesis of amyloid-related disorders: familial amyloidotic polyneuropathy as a case study NORTE-01-0145-FEDER-000008 40k€ Investigador responsável Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	QREN, FEDER and FCT Concluído
2015/01/01 - 2018/12/31	Setting a rational screening program for transthyretin-ABeta binding stabilizing compounds that may lead to potential Alzheimer´s disease modulating drugs. 20140330-31-32-33-34. Investigador	Fundació la Marató de TV3 Concluído
2017 - 2018	Promoting Cytoskeleton Biology @IBMC 38/2017 Investigador	Fundação Luso-Americana Concluído
2012/05/01 - 2015/09/30	Transthyretin is a metalloprotease: possible implications in nervous system diseases PTDC/SAU-ORG/118863/2010 165k€ Investigador responsável Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/06/01 - 2015/06/30	Proteolysis and Neurodegeneration NORTE-07-0124-FEDER-000001 60k€ Investigador responsável Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	QREN, FEDER and FCT Concluído
2013/05/01 - 2015/04/30	Modulating Actin Dynamics during axonal regeneration: the role of adducin and profilin-1. P140 Investigador	Fondation internationale pour la recherche en paraplégie
2011/01/01 - 2014/03/31	DISSECTING NERVE REGENERATION AND THE NEURITOGENIC ACTIVITY OF TTR PTDC/SAU- GMG/111761/2009 Bolseiro de Pós-Doutoramento	Fundação para a Ciência e a Tecnologia Concluído
2011/11/01 - 2013/06/30	Characterization of cell-intrinsic axonal regeneration determinants and their use to promote repair after CNS injury. HMSP- ICT/0020/2010 Bolseiro de Pós-Doutoramento	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2010	Search for the molecular basis of TTR involvement in the biology of the nervous system. PTDC/BIA-PRO/64437/2006 Bolseiro de Doutoramento Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2009	Finding the relevance of the proteolytic activity of transthyretin in muscle and nerve physiology. AFM 12421 Bolseiro de Doutoramento	AFM-Téléthon Fundação para a Ciência e a Tecnologia
2006/01/01 - 2006/12/31	Apolipoprotein AI cleavage by transthyretin: impact in health and amyloidosis. Apolipoprotein AI cleavage by transthyretin: impact in health and amyloidosis. 10k€ Investigador responsável Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação Calouste Gulbenkian Concluído
2002 - 2004	A novel function of transthyretin: involvement in proteolysis. POCTI/BCI/3824/2001 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2019/01/01 - 2019/12/31	Institute for Research and Innovation in Health Sciences UID/BIM/04293/2019 LA/P/0070/2020 10.54499/LA/P/0070/2020 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/31	Strategic Project - LA 2 - 2011-2012 PEst-C/SAU/LA0002/2011 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2022/01/01 - 2022/12/31	Research Agreement with Creative Bio-Peptides Inc. Novel therapeutics to synaptic dysfunction in Parkinson’s Disease: targeting CCR5 chemokine receptor. NA Investigador responsável

Produções

Publicações

Artigo em revista	Portugal, Camila; Monteiro-Pacheco, Ana; Santos, ECS; Liz, Márcia Almeida; Socodato, Renato; Bettencourt Relvas, João. "Modulating vitamin C transport in hippocampal microglia to target synapse and memory deficits in Parkinson’s Disease". Free Radical Biology and Medicine 218 (2024): 9-10. http://dx.doi.org/10.1016/j.freeradbiomed.2024.04.040. Publicado • 10.1016/j.freeradbiomed.2024.04.040 Oliveira da Silva, Marina I.; Santejo, Miguel; Babcock, Isaac W.; Magalhães, Ana; Minamide, Laurie S.; Won, Seok-Joon; Castillo, Erika; et al. Autor correspondente: Liz, Márcia Almeida. "a-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway". Cell Death & Disease 15 4 (2024): http://dx.doi.org/10.1038/s41419-024-06630-9. 10.1038/s41419-024-06630-9 • Pessoal de suporte Saavedra, Joana; Nascimento, Mariana; Liz, Marcia A.; Cardoso, Isabel. "Key brain cell interactions and contributions to the pathogenesis of Alzheimer's disease". Frontiers in Cell and Developmental Biology (2022): https://publons.com/wos-op/publon/54613772/. 10.3389/FCELL.2022.1036123 Cotrina, Ellen Y.; Santos, Luis Miguel; Rivas, Josep; Blasi, Daniel; Leite, José Pedro; Liz, Márcia A.; Busquets, Maria Antònia; et al. "Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease". European Journal of Medicinal Chemistry 226 (2021): 113847. http://dx.doi.org/10.1016/j.ejmech.2021.113847. Publicado • 10.1016/j.ejmech.2021.113847 Eira, Jessica; Magalhães, Joana; Macedo, Nídia; Pero, Maria Elena; Misgeld, Thomas; Sousa, Mónica M.; Bartolini, Francesca; Liz, Márcia A.. "Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.747699. Publicado • 10.3389/fcell.2021.747699 Sampaio-Dias, Ivo E.; Santejo, Miguel; Silva-Reis, Sara C.; Liz, Márcia A.; Alcoholado, Cristina; Algarra, Manuel; García-Mera, Xerardo; Rodríguez-Borges, José E.. "Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate". ACS Chemical Neuroscience (2021): http://dx.doi.org/10.1021/acschemneuro.1c00339. Publicado • 10.1021/acschemneuro.1c00339 Magalhães, Joana; Eira, Jessica; Liz, Márcia Almeida. "The role of transthyretin in cell biology: impact on human pathophysiology". Cellular and Molecular Life Sciences 78 17-18 (2021): 6105-6117. http://dx.doi.org/10.1007/s00018-021-03899-3. Publicado • 10.1007/s00018-021-03899-3 Liz, Márcia Almeida. "A Narrative Review of the Role of Transthyretin in Health and Disease". Neurology and Therapy (2020): http://dx.doi.org/10.1007/s40120-020-00217-0. 10.1007/s40120-020-00217-0 I. Oliveira da Silva, Marina; Lopes, Carla S.; Liz, Márcia A.. "Transthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-70377-4. 10.1038/s41598-020-70377-4 Liz, Márcia Almeida. "Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function". Frontiers in Cell and Developmental Biology (2020): http://dx.doi.org/10.3389/fcell.2020.00787. 10.3389/fcell.2020.00787 Liz, Márcia Almeida. "Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration". Journal of Clinical Investigation (2020): http://dx.doi.org/10.1172/jci125771. 10.1172/jci125771 Liz, Márcia Almeida. "Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation". Frontiers in Cellular Neuroscience (2019): http://dx.doi.org/10.3389/fncel.2019.00005. 10.3389/fncel.2019.00005 Silva, C.S.; Eira, J.; Ribeiro, C.A.; Oliveira, Â.; Sousa, M.M.; Cardoso, I.; Liz, M.A.. "Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis". Neurobiology of Aging 59 (2017): 10-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026736800&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2017.07.002 Oliveira da Silva, M. I.; Outeiro, T. F.; Bamburg, J. R.; Liz, M. A.. "Cofilin-actin rods as mediators of a-synuclein-induced synaptic dysfunction in Parkinson's disease". Molecular Biology of the Cell (2017): https://publons.com/wos-op/publon/16533540/. Eira J; Silva CS; Sousa MM; Liz MA. "The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders.". (2016): http://europepmc.org/abstract/med/27095262. 10.1016/j.pneurobio.2016.04.007 Miranda, C.O.; Teixeira, C.A.; Sousa, V.F.; Santos, T.E.; Liz, M.A.; Marques, A.M.; Pinto-do-Ó, P.; Sousa, M.M.. "Primary bone marrow mesenchymal stromal cells rescue the axonal phenotype of twitcher mice". Cell Transplantation 23 2 (2014): 239-252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893339069&partnerID=MN8TOARS. 10.3727/096368913X669752 Liz, Marcia A.; Mar, Fernando M.; Santos, Telma E.; Pimentel, Helena I.; Marques, Ana M.; Morgado, Marlene M.; Vieira, S-Lvia; et al. "Neuronal deletion of GSK3 beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2". Bmc Biology 12 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000209614600001&KeyUID=WOS:000209614600001. 10.1186/1741-7007-12-47 Gouvea, I.E.; Kondo, M.Y.; Assis, D.M.; Alves, F.M.; Liz, M.A.; Juliano, M.A.; Juliano, L.. "Studies on the peptidase activity of transthyretin (TTR)". Biochimie 95 2 (2013): 215-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872809042&partnerID=MN8TOARS. 10.1016/j.biochi.2012.09.014 Liz, M.A.; Leite, S.C.; Juliano, L.; Saraiva, M.J.; Damas, A.M.; Bur, D.; Sousa, M.M.. "Transthyretin is a metallopeptidase with an inducible active site". Biochemical Journal 443 3 (2012): 769-778. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860178075&partnerID=MN8TOARS. 10.1042/BJ20111690 Miranda, C.O.; Teixeira, C.A.; Liz, M.A.; Sousa, V.F.; Franquinho, F.; Forte, G.; Di Nardo, P.; Pinto-Do-Ó, P.; Sousa, M.M.. "Systemic delivery of bone marrow-derived mesenchymal stromal cells diminishes neuropathology in a mouse model of Krabbe's disease". Stem Cells 29 11 (2011): 1738-1751. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054957115&partnerID=MN8TOARS. 10.1002/stem.724 Franquinho, F.; Liz, M.A.; Nunes, A.F.; Neto, E.; Lamghari, M.; Sousa, M.M.. "Neuropeptide y and osteoblast differentiation - The balance between the neuro-osteogenic network and local control: Review Article". FEBS Journal 277 18 (2010): 3664-3674. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956337408&partnerID=MN8TOARS. 10.1111/j.1742-4658.2010.07774.x Liz, M.A.; Mar, F.M.; Franquinho, F.; Sousa, M.M.. "Aboard transthyretin: From transport to cleavage". IUBMB Life 62 6 (2010): 429-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953605034&partnerID=MN8TOARS. 10.1002/iub.340 Nunes, A.F.; Liz, M.A.; Franquinho, F.; Teixeira, L.; Sousa, V.; Chenu, C.; Lamghari, M.; Sousa, M.M.. "Neuropeptide y expression and function during osteoblast differentiation - Insights from transthyretin knockout mice". FEBS Journal 277 1 (2010): 263-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-73649127668&partnerID=MN8TOARS. 10.1111/j.1742-4658.2009.07482.x Liz, M.A.; Fleming, C.E.; Nunes, A.F.; Almeida, M.R.; Mar, F.M.; Choe, Y.; Craik, C.S.; et al. "Substrate specificity of transthyretin: Identification of natural substrates in the nervous system". Biochemical Journal 419 2 (2009): 467-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249132020&partnerID=MN8TOARS. 10.1042/BJ20082090 Liz, M.A.; Gomes, C.M.; Saraiva, M.J.; Sousa, M.M.. "ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity". Journal of Lipid Research 48 11 (2007): 2385-2395. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848967214&partnerID=MN8TOARS. 10.1194/jlr.M700158-JLR200 Liz, M.A.; Sousa, M.M.. "Deciphering cryptic proteases". Cellular and Molecular Life Sciences 62 9 (2005): 989-1002. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544370514&partnerID=MN8TOARS. 10.1007/s00018-005-4544-2 Liz, M.A.; Faro, C.J.; Saraiva, M.J.; Sousa, M.M.. "Transthyretin, a new cryptic protease". Journal of Biological Chemistry 279 20 (2004): 21431-21438. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442635419&partnerID=MN8TOARS. 10.1074/jbc.M402212200
Livro	Fleming, C.E.; Nunes, A.F.; Liz, M.A.; Sousa, M.M.. TTR null mice as a model to study the involvement of TTR in neurobiology: From neuropeptide processing to nerve regeneration. 2009. 10.1007/978-3-642-00646-3_19
Poster em conferência	Correia, Xavier Cruz; Sara C. Silva-Reis; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Miguel Santejo; Liz, Márcia Almeida; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Autor correspondente: Ivo E. Sampaio-Dias. "Assembly of Bioactive Glypromate Derivatives using 2-Azanorbornane as a Proline Isostere". Trabalho apresentado em X SEQT Symposium of Medicinal Chemistry Young Researchers, 2024. Saavedra, Joana; Nascimento, Mariana; Oliveira da Silva, Marina Isabel; Liz, Márcia Almeida; Cardoso, Isabel. "Transthyretin reverts Aß-induced cofilin pathology and synaptic dysfunction". Trabalho apresentado em One health PhD forum, 2024. Carvalho, Estefânia; Dias, Andreia; Liz, Márcia Almeida; Coelho, Teresa; Sousa, Alda; Alves-Ferreira, Miguel; Santos, Mariana; Lemos, Carolina. "New genetic modifiers of age-at-onset in ATTRV30M amyloidosis". Trabalho apresentado em 57th European Human Genetics Conference, 2024. Saavedra, Joana; Nascimento, Mariana; Oliveira da Silva, Marina Isabel; Liz, Márcia Almeida; Cardoso, Isabel. "Unraveling the protection of neuronal cytoskeleton and synaptic structures by TTR". Trabalho apresentado em XIX International Symposium on Amyloidosis (ISA 2024), 2024. Dias P. Vítor; Magalhães, J.; Nóvoa, G.; S-T Hsieh; Liz, Márcia Almeida. Autor correspondente: Liz, Márcia Almeida. "Microtubule dynamics and axonal transport are impaired in Transthyretin Amyloid Polyneuropathy". Trabalho apresentado em IJUP, 2023. Pacheco, Ana M.; Santos, ECS; Bettencourt Relvas, João; Liz, Márcia Almeida; Portugal, CC. "Modulating Ascorbate Transport in Hippocampal Microglia to Target Learning and Memory Deficits in Parkinson's Disease". Trabalho apresentado em FENS (Federation of European Neuroscience Societies) Regional Meeting, 2023. Pacheco, Ana M.; Santos, ECS; Bettencourt Relvas, João; Liz, Márcia Almeida; Portugal, CC. "Overexpressing SVCT2 in Hippocampal Microglia to Target Learning and Memory Deficits in Parkinson's Disease". Trabalho apresentado em 9th MCBiology Symposium, 2023. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Miguel Santejo; Liz, Márcia Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. Autor correspondente: Ivo E. Sampaio-Dias. "Discovery of Neuroprotective Hits Using 2-Azanorbornane as a Constrained Proline Surrogate in Glypromate Neuropeptide". Trabalho apresentado em Congreso Internacional: XXVI Encontro Galego-Portugués de Química, 2022. Ana Monteiro-Pacheco; Santos, ECS; Bettencourt Relvas, João; Liz, Márcia Almeida; Portugal, CC. "Overexpressing SVCT2 in Microglia to Target Learning and Memory Deficits in Parkinson's Disease". Trabalho apresentado em VI Symposium of the Portuguese Glial Network, 2022. Pacheco, Ana M.; Santos, ECS; Liz, Márcia Almeida; Bettencourt Relvas, João; Portugal, CC. "Overexpressing SVCT2 in Microglia to Target Learning and Memory Deficits in the Thy1-aSyn Mice Model of Parkinson's Disease". Trabalho apresentado em IJUP¿22 - 15º Encontro de Investigação Jovem da Universidade do Porto, 2022. Pacheco, Ana M.; Santos, ECS; Liz, Márcia Almeida; Bettencourt Relvas, João; Portugal, Camila. "Modulating Ascorbate Transport in Microglia to Target Learning and Memory Deficits in Parkinson's Disease". Trabalho apresentado em 8th MCBiology Symposium, 2022. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Miguel Santejo; Liz, Márcia Almeida; Cristina Alcoholado; Algarra, Manuel; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Probing Constrained Prolines for the Assembly of Neuroprotective Glypromate® Peptidomimetics". Trabalho apresentado em RICT ¿ 56th International Conference on Medicinal Chemistry (Interfacing Chemical Biology and Drug Discovery), 2021. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Liz, Márcia Almeida; José Enrique Rodríguez Borges. "Development of New GPE Conjugates with Potentially Synergistic Properties (Desenvolvimento de Novos Conjugados do GPE com Propriedades Potencialmente Sinérgicas)". Trabalho apresentado em XXIV Encontro Luso-Galego de Química, 2018. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Jéssica Eira; Liz, Márcia Almeida; J. E. Rodriguez-Borges. "Exploring the Potential Synergic Effect of GPE Lipophilic Conjugates with Neuroprotective Amines". Trabalho apresentado em 12º Encontro Nacional de Química Orgânica (ENQO) / 5º Encontro Nacional de Química Terapêutica (ENQT), 2018.
Pré-impressão	Magalhaes, Joana; Dias, Vitor; Eira, Jessica; Novoa, Guilherme; Oliveira da Silva, Marina I; Kan, Yu Yu; Dias, Andreia; et al. "Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy". 2024. http://dx.doi.org/10.1101/2024.11.27.625664. 10.1101/2024.11.27.625664 Zsuzsa Sárkány; Tiago Gião; Márcia Almeida Liz; Antoni Planas; Sandra Macedo-Ribeiro; Isabel Cardoso; Gemma Arsequell; Pedro M. Martins. "Transthyretin has conformation-selective proteolytic activity against a-synuclein". 2023. https://doi.org/10.1101/2023.08.10.552896. 10.1101/2023.08.10.552896 Oliveira da Silva, MI; Santejo, M; Babcock, IW; Magalhães, A; Minamide, LS; Castillo, E; Gerhardt, E; et al. "Cofilin pathology is a new player on a-synuclein-induced spine impairment in models of hippocampal synucleinopathy". 2021. http://dx.doi.org/10.1101/2021.02.02.425931. 10.1101/2021.02.02.425931 Jessica Eira; Joana Magalhães; Nídia Macedo; Maria Elena Pero; Thomas Misgeld; Mónica M Sousa; Francesca Bartolini; Márcia A Liz. "Transthyretin promotes axon growth via regulation of microtubule dynamics and tubulin acetylation". 2021. https://doi.org/10.1101/2021.03.24.436762. 10.1101/2021.03.24.436762
Resumo em conferência	Magalhaes, Joana; Eira, Jéssica; Dias P. Vítor; Nóvoa, Guilherme; Oliveira da Silva, Marina Isabel; Yu-Yu Kan; Dias, A.; et al. Autor correspondente: Liz, Márcia Almeida. "Rac1 activation triggers axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy". Trabalho apresentado em 2024 International Symposium on Amyloidosis, Rochester, Minnesota, 2024. Liz, Márcia Almeida. Autor correspondente: Liz, Márcia Almeida. "Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy". Trabalho apresentado em 2023 Peripheral Nerve Society Annual Meeting, Copenhagen, 2023. Aceite para publicação Liz, Márcia Almeida. "Alpha-Synuclein induces cofilin pathology: implications on the molecular basis of Parkinson's disease". Trabalho apresentado em American Society for Cell Biology, San Diego, United States., San Diego, 2018. Liz, Márcia Almeida. "Profilin1 coordinates actin and microtubule dynamics to enhance axon growth and regeneration". Trabalho apresentado em American Society for Cell Biology, 2018. Publicado Liz, Márcia Almeida. "Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease.". Trabalho apresentado em American Society for Cell Biology, 2017. Liz, Márcia Almeida. "GSK3 beta activity and CNS axonal regeneration: insights from in vivo studies". Trabalho apresentado em American Society for Cell Biology, 2011. Publicado Liz, Márcia Almeida. "Mesenchymal stromal cells immortalized with MTERT promote axonal outgrowth". Trabalho apresentado em 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009. Publicado
Tese / Dissertação	Liz, Márcia Almeida. "Novel Function of Transthyretin: Involvement in Proteolysis". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2008.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/05/28	Rac1 activation triggers axonal cytoskeleton dysfunction in transthyretin amyloid polyneuropathy.	XIX International Symposium on Amyloidosis. Rochester, Minnesota, USA. (Rochester, Minnesota., Estados Unidos)
2023/11/10	Rac1 induces axonal degeneration in Transthyretin Amyloid Polyneuropathy	Neuro Day Meeting of the Neurobiology and Neurologic Disorders program i3S (Porto, Portugal)
2023/06/29	Transthyretin: from health to disease	ATTR amyloidosis preceptorship course Porto Medical Center (Porto, Portugal)
2023/06/20	Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy	Peripheral Nerve Society Annual Meeting 2023 (Copenhagen, Dinamarca)
2022/12/03	Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy	EMBO workshop: Neural development and Neurodegeneration EMBO (Taipe, Taiwan)
2022/11/03	Axonal cytoskeleton alterations in Transthyretin Amyloid Polyneuropathy	Seminar at Gottingen University Gottingen University (Alemanha)
2021/06/28	ATTR amyloidosis: an underrecognized disease	Pfizer-sponsored satellite symposium at the 2021 PNS Annual Meeting (virtual) Peripheral Nerve Society/Pfizer
2019/09/30	Actin Dysfunction in Neurodegeneration	One day meeting on Neurobiology and Neurological Disorders. I3S/ Discoveries CTR. (Portugal)
2019/07/16	Peripheral neuronal cultures for studies of transthyretin-induced Familial Amyloid Polyneuropathy	Summer Workshop- Neuronal Systems & Culture Methods for Studying Neuronal Disorders at the Cell and Molecular Level Colorado State University (Fort Collins, Estados Unidos)
2018/04/12	Protein misfolding and cytoskeleton dysfunction: a link to neurodegeneration?	NEUROBIOLOGY AND NEUROLOGIC DISORDERS i3S
2017/05	Actin cytoskeleton disruption as a novel player in the pathogenesis of familial amyloid polyneuropathy.	Mediterranean Neuroscience Society. Malta Mediterranean Neuroscience Society. (Malta)
2014	Cytoskeleton remodeling: a consequence of TTR exposure?	ON2 Symposium on Neurodegenerative Disorders. IBMC, Porto, Portugal. (Portugal)
2013	Neuronal deletion of GSK3ß increases microtubule dynamics in the growth cone enabling axonal regeneration.	XIII Meeting of the Portuguese Society for Neuroscience. Portuguese Society for Neuroscience. (Portugal)
2012	Unraveling axonal regeneration enhancers.	Neuroscience lectures. UTAD University (Portugal)
2012	Partial downregulation of GSK3beta activity by decreased Tyr216 phosphorylation promotes axonal regeneration through the glial scar.	I3S scientific retreat
2011	Unraveling axonal regeneration enhancers	IV Biochemistry lectures UTAD University (Portugal)
2010	GSK3beta as a central pathway promoting axonal regeneration following conditioning lesions.	FEBS/EMBO lecture course: The cytoskeleton in Development and Pathology. FEBS/EMBO (Suécia)
2007	TTR proteolytic activity enhances apoA-I fibril formation	Biochemical Society Meeting. New approaches for elucidating protease biology and therapeutic opportunities. Biochemical Society (Reino Unido)
2006	The Proteolytic activity of transthyretin: impact in health and disease.	PhD Training Series. IBMC - Porto, Portugal.
2006	Finding new functions for old proteins.	Young Scientist Week. Visionarium, Santa Maria da Feira, Portugal.
2005	Cryptic Proteses in Physiological and Pathological conditions.	VI Jornadas Técnicas de Engenharia Biotecnológica subordinadas ao tema: As Potencialidades das Enzimas na Bioengenharia.
2004	Transthyretin: a cryptic protease activity.	Gordon Research Conference on Proteolytic Enzymes & their inhibitors. (Estados Unidos)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2025/01/01 - Atual	TTRinBRAIN: Deciphering Brain Pathology in Transthyretin Amyloidosis. Orientador	Doctoral Program in Molecular and Cell Biology (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/09/01 - Atual	A human sensory neuron model to explore the pathophysiology of Transthyretin Amyloid Polyneuropathy Orientador	Master in Molecular Biomedicine. (Mestrado) Universidade de Aveiro, Portugal
2022/01/01 - 2025/12/31	Dissecting unexplored mechanisms underlying Transthyretin neuroprotection in Alzheimer's Disease. Coorientador de Joana Saavedra	MCbiology PhD Program (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/15 - 2023/12/07	Exploring microtubule and axonal transport defects in Transthyretin Amyloid Polyneuropathy (ATTR-PN) Orientador de Vitor Dias	Master in Molecular Medicine (Mestrado) Universidade de Aveiro, Portugal
2021/10/01 - 2022/11/14	Exploring axonal cytoskeleton defects in Transthyretin Amyloid Polyneuropathy (ATTR-PN). Orientador de Guilherme Nóvoa	Master in Biochemistry Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2021/09/14	Actin dysfunction in neurodegenerative disorders: Uncovering Cofilin-1 pathology in Lewy Body dementias Orientador de Marina Isabel Oliveira da Silva	Biologia Molecular e Celular (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2021/05/12	New insights on the impact of Transthyretin in neuroprotection and neurodegeneration Orientador de Jessica Faria da Eira	Biologia Molecular e Celular (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/01 - 2019	Impact of cofilin-actin rods formation on Parkinson’s Dementia Orientador de Miguel Gil Afonso Santejo	Mestrado em Bioquímica Aplicada (Mestrado) Universidade do Minho, Portugal
2017/08/31 - 2018/11/27	TTR-induced cytoskeleton remodelling: a double-edged sword Orientador de Nídia Sampaio Macedo	Neurobiologia (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2016	Dissecting the role of Transthyretin on neuritogenesis: impact on axonal transport? Orientador de Inês Santos Pires	Estágio de Licenciatura em Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2015 - 2015	Dissecting the role of cytoskeleton remodelling in a Drosophila model of TTR-induced neurodegeneration Orientador de Marina Isabel Oliveira da Silva	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2015 - 2015	Dissecting the role of Proteolysis and Cytoskeleton remodeling in protein aggregation related diseases Orientador de Catarina Santos Silva	Bioengenharia (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2014 - 2014	Transthyretin: a protein involved in nerve regeneration and neurodegeneration Orientador de Catarina Santos Silva	Estágio de licenciatura em Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2010 - 2011	Glycogen synthase kinase 3ß modulation in axonal regeneration Orientador de Helena Isabel da Costa Antunes Pimentel	Biomedicina Molecular (Mestrado) Universidade de Aveiro, Portugal
2009 - 2010	Identifying proteins differentially expressed following conditioning lesions. Coorientador de Daniela Filipa Lage da Silva	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2010	Insights into the function of transthyretin in the peripheral nerve and bone biology Coorientador de Filipa Sofia Franquinho Ferreira	Terapias Moleculares (Mestrado) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2022/09/01 - Atual	Bioengineering Hub (2022/09/20) Simpósio (Membro da Comissão Organizadora)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - Atual	Porto de Crianças: "À descoberta do cérebro". (2016)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/04/27 - 2023/04/27	NeuroBingo: challenges on Neurodegeneration (2023/04/27) Mesa-redonda (Presidente da Comissão Organizadora)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/06/04 - 2015/06/05	XIV Meeting of the Portuguese Society for Neuroscience. Póvoa de Varzim, Portugal. June 4-5, 2015. (2015/06/04 - 2015/06/05) Encontro (Membro da Comissão Organizadora)
2014/07/08 - 2014/07/08	ON2 Symposium on Neurodegenerative Disorders (2014/07/08 - 2014/07/08) Simpósio (Coorganizador)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2023/11/17 - Atual	Chair: Neurobiology and Neurological Disorders speed talks session Encontro	10th Annual Meeting Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/10/04 - Atual	Chair Neurobiology and Neurologic Disorders session Simpósio	5th PhDay: “Building Paths: The Science Behind Us” Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/06/01 - 2032/06/08	Research Project Management 2nd Edition Oficina (workshop)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 - 2015	High School visits at IBMC•INEB.
2010 - 2010	Brain Awareness Week

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2023/11/23	Characterisation of microglial response to Environmental Enrichment: the role of the RhoGTPases Rac1 Arguente principal	João Francisco Galvão Dias e Vasconcelos Ferreira (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2023/06/30	iPSC-Derived Human Sensory Neurons Cultures in vitro Recapitulate Physiological features Arguente principal	Ricardo Ramos Ribeiro (Outro) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/05/05	The extracellular memories in Parkinson's Disease Arguente principal	Ana Maria Salgueiro Freitas (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2021	Study of the regulatory effect of the neuronal activity on axonal transport dynamics. Arguente principal	Catarina Eduarda Fernandes Ricardo. (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2021	SIMPLER: Fungi-to-human drug screening platforms towards the treatment of neurodegenerative disorders. Arguente principal	Francisca Coelho. (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2020/10/29	Prova Probatoria: Unveiling the roles of small Rho GTPase Rac1 in microglia homeostasis and activation during neuroinflammation Vogal	Tiago Almeida (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/11/26	Deciphering the role of RhoA in microglia inflammation Arguente principal	Artur Santos Rodrigues (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2018/12/03	Regulation of developmental myelination in the peripheral nervous system by Rho signalling Arguente principal	Miguel Rafael Gonçalves Morais (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2018/11/27	TTR-induced cytoskeleton remodelling: a double-edged sword Orientador	Nídia Sampaio Macedo (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2017/10/23	Effect of Transthyretin in the brain vasculature - Implications in physiology and pathology Arguente principal	José Ricardo da Cruz Vieira (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2017	Refining cell-based delivery systems for brain neurotransmitters release Arguente principal	Filipe Miguel Paredes Oliveira (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2015/11/25	Dissecting the role of cytoskeleton remodelling in a Drosophila model of TTR-induced neurodegeneration Orientador	Marina Isabel Oliveira da Silva (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2015/10/29	The oligodendrocyte "processosome": novel regulators of differentiation and myelination Arguente principal	Ana Filipa Bouçanova da Silva (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2015/10/06	Understanding the protective effects of Neurosteroids and Endocannabinoids in Schizophrenia Using hiPSC-Derived Neurons Arguente principal	Sara Marisa Cardoso Macedo (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2015	Dissecting the role of Proteolysis and Cytoskeleton remodeling in protein aggregation related diseases. Orientador	Catarina Santos Silva (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2014/07/24	Modulating the extracellular environment during axonal regeneration following spinal cord injury Arguente principal	Marlene Marques Morgado (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2012/09/27	The role of RhoA in stroke recovery Arguente principal	Ana Catarina Silva Fonseca (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2011	Glycogen synthase kinase 3ß modulation in axonal regeneration Orientador	Helena Isabel da Costa Antunes Pimentel (Mestrado) Universidade de Aveiro, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/09/01 - Atual	Biomedicines (Guest Editor guest editor of the issue: "The Pathophysiology of Peripheral Nerve Injuries")
2022/09/01 - Atual	Frontiers in Aging Neuroscience (Review Editor for Aging Neuroscience Archive)
2017/01/01 - Atual	Frontiers in Neuroscience (Review Editor for Neurodegeneration)
2017/12/07 - 2017/12/25	Neurological Sciences
2017/10/24 - 2017/12/11	Frontiers in Cellular Neuroscience
2017/08 - 2017/08	International Journal of Brain Disorders and Treatment
2017/05/02 - 2017/06/26	Translational Neurodegeneration
2017/03/20 - 2017/05/16	FEBS Letters
2016/11 - 2016/12	Disease Models & Mechanisms (1754-8411)	The Company of Biologists
2016/05 - 2016/05	International Journal of Neurology and Neurotherapy
2015 - 2016	Journal of Neuroscience
2015/03/18 - 2015/10/31	Biochemistry and Biophysics Reports
2015/07/08 - 2015/07/29	Neuroscience
2015 - 2015	Cytoskeleton (1949-3592)	Wiley (John Wiley & Sons)
2014/02 - 2014/02	BioMolecular Concepts (1868-503X)	Walter de Gruyter GmbH

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2018/08 - Atual	Peer review for Parkinson's UK application Avaliador	Parkinson's UK, Reino Unido

Consultoria / Parecer

	Descrição da atividade	Instituição / Organização
2018/09/26 - 2018/09/26	Scientific Adivisor at Pfizer Advisory Board meeting: TTR in health and disease.	Pfizer Sa, Espanha

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2010 - Atual	Neuroscience PhD and MSc Programs	Nerve Regeneration (Doutoramento)	Universidade do Porto Faculdade de Medicina, Portugal
2019/07/16 - 2019/07/17	Summer Workshop on Neuronal Systems & Culture Methods for Studying Neuronal Disorders at the Cell and Molecular Level		Colorado State University, Estados Unidos
2011 - 2018	Graduate Program in Areas of Basic and Applied Biology (GABBA)	Nerve Regeneration (Doutoramento)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2024/01/03	Risco aumenta quase 25%. Investigadores associam bactéria a Alzheimer precoce.	Jornal de Noticias
2021/09/21	Como estabilizar uma proteína pode ser a chave para travar Alzheimer	Jornal de Noticias

Entrevista / Programa (rádio / tv)

	Programa	Tema
2021/09/29 - Atual	Mentes Que Brilham - Porto Canal	Exploring axonal microtubule and mitochondrial transport defects in Transthyretin Amyloid Polyneuropathy (ATTR-PN)

Tutoria

	Tópico	Nome do aluno
2024/09/01 - Atual	Supervision of Junior Researcher (2022.03338.CEECIND; FCT)	Marina Silva
2023/01/01 - Atual	Supervision of Junior Researcher (Funding: Pfizer)	Marina Silva
2022/01/01 - 2022/12/31	Supervision of Junior Researcher (Creative Bio-peptides Funding)	Marina Silva
2019/01/01 - 2021/10/30	Supervision of Junior Researcher	Joana Miguel Magalhaes
2019/11/01 - 2020/10/30	Supervision of Research Fellow	Miguel Gil Santejo
2018/10/01 - 2020/01/31	Supervision of Research Fellow	Nídia Sampaio Macedo.
2015/10/01 - 2015/12/31	Supervision of research fellow	Marina Silva
2013/07/01 - 2015/09/30	Supervision of Research Fellow	Jéssica Faria da Eira
2012/05/01 - 2013/08/31	Supervision of Research Fellow	Telma Santos

Distinções

Prémio

2019	Senior International Summer Scholar Award Colorado State University, Estados Unidos
2006	Gulbenkian Prize for Young Investigators. Fundação Calouste Gulbenkian, Portugal

Outra distinção

2024	Assistant Researcher Contract (undetermined time) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022	Institutional Call to Scientific Employment Stimulus - Assistant researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016	FCT Investigator 2015- Starting Grant. Fundação para a Ciência e a Tecnologia, Portugal
2015	Postdoc fellowship Fundação para a Ciência e a Tecnologia, Portugal
2008	Postdoc fellowship Fundação para a Ciência e a Tecnologia, Portugal
2005	PhD Scholarship Fundação para a Ciência e a Tecnologia, Portugal
2004	PhD Scholarship AFM-Téléthon, França
2000	Trainee Program Award of ICEP/Portuguese Ministry of Economy