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Daniel José da Costa Barbosa completed an Integrated Master’s in Pharmaceutical Sciences in 2009 and a PhD in Pharmaceutical Sciences – Specialty of Toxicology in 2013 at the University of Porto. He is currently an Assistant Professor at Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), an Integrated Researcher at the Associate Laboratory i4HB – Institute for Health and Bioeconomy, University Institute of Health Sciences – CESPU, as well as at UCIBIO – Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), and colaborates with i3S - Institute for research and Innovation in Health - UP. Daniel Barbosa works in the fields of Molecular and Cell Biology, Neurosciences, Pharmacology, Toxicology, and Forensic Sciences. He has published forty four articles in peer-reviewed international journals (most in Q1 journals within their respective fields), twenty five abstracts in peer-reviewed international journals, and three book chapters. Additionally, he has presented numerous posters and delivered oral presentations at national and international conferences. He has participated in or is currently involved in eight research projects funded by national and international agencies. Over the years, he has served as a reviewer for several peer-reviewed international journals. He has supervised two Undergraduate Students and one Master’s Student and co-supervised one Master’s Student and one PhD Student. Currently, he supervises oneMaster’s Student and fourUndergraduate Students, and co-supervises two Master's Students, and two PhD Students. In his curriculum vitae, the most frequently occurring terms related to his scientific and technological production are: microtubules, intracellular transport, molecular motors, dynein, dynactin, intracellular organelles, CRISPR-Cas9, C. elegans, oxidative stress, MDMA ("ecstasy"), drugs of abuse, neurosciences, neurotoxicology, forensic sciences, and forensic toxicology.
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Identification

Personal identification

Full name
Daniel José da Costa Barbosa

Citation names

  • Barbosa, Daniel José
  • Barbosa, DJ
  • Barbosa, D.J.

Author identifiers

Ciência ID
FE1C-104F-37C1
ORCID iD
0000-0002-1726-6011
Scopus Author Id
54931587700

Email addresses

  • daniel.barbosa@iucs.cespu.pt (Professional)
  • daniel.barbosa@iucs.cespu.pt (Professional)

Addresses

  • Instituto Universitário de Ciências da Saúde (IUCS), Rua Central da Gandra 1317 4585, Gandra, 4585, Gandra, Paredes, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Other Medical Sciences - Forensic Science
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
French Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2) Beginner (A1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2013/12/20
Concluded
 Ciências Farmacêuticas (Doutoramento)
Major in Toxicologia
Universidade do Porto Faculdade de Farmácia, Portugal
"Ecstasy´s Neurotoxicity: In Vitro Findings from Mitochondria to the Cell" (THESIS/DISSERTATION)
2009/09/24
Concluded
 Ciências Farmacêuticas (Mestrado integrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Factores que influenciam a utilização de estatinas e seus benefícios para além das dislipidémias" (THESIS/DISSERTATION)
 15
2008/06/13
Concluded
 Estudos Básicos de Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2024/03/01 - Current Researcher (Research) Unidade de Ciências Biomoleculares Aplicadas, Portugal
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2019/01/01 - 2024/02/29 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
2014/04/01 - 2018/12/31 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
(...)
2009/03/01 - 2009/09/30 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/02/01 - Current Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2018 - 2019 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2010/04/01 - 2013/12/31 Tutor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2025/07 - Current Editorial Board Member of the Scientific Journal "Current Drug Research Reviews" Bentham Science Publishers Ltd, United Arab Emirates
2025/01 - Current Editorial Board Member of the Scientific Journal "Neurotoxicology" Elsevier BV, Netherlands
2024/11 - Current Co-Editor-in-Chief of the Scientific Journal "Curent Forensic Science" Bentham Science Publishers Ltd, United Arab Emirates
2023/09 - 2024/11 Editorial Board Member of the Scientific Journal "Curent Forensic Science" Bentham Science Publishers Ltd, United Arab Emirates

Others

Category
Host institution 		Employer
2009/09 - 2010/01 Pharmacist Lemos & Fihos, Lda , Portugal
Projects

Grant

Designation Funders
2014/04/01 - 2019/10/31 Cytoplasmic Dynein: Mechanisms of Regulation and Novel Interactors
info:eu-repo/grantAgreement/EC/FP7/338410/EU
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Commission
Concluded
2015/03/01 - 2018/12/31 Neurodegenerative diseases caused by mutations in p150/Glued: Generation of novel animal models and identification of disease modifiers
SFRH/BPD/101898/2014
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/12/31 Contribution of mitochondrial dysfunction for the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy)
SFRH/BD/64939/2009
PhD Student Fellow
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2025/09/01 - 2026/08/31 Decoding the toxicity and transgenerational effects of synthetic cathinones and ketamine enantiomers using C. elegans as a translational model
DeTTeCaK-GI2-CESPU-2025
Principal investigator
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
Cooperativa de Ensino Superior Politécnico e Universitário
Ongoing
2022/01 - 2024/02/29 Axonal transport regulation by motor-cargo adaptors
PTDC/BIA-CEL/1321/2021
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2024/02/29 Institute for Research and Innovation in Health
DL 57/2016/CP1355/CT0007
LA/P/0140/2020
10.54499/LA/P/0140/2020
LA/P/0070/2020
UIDB/04293/2020
UIDP/04293/2020
UID/BIM/04293/2019
Researcher
Instituto de Biologia Molecular e Celular, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021/07/01 - 2023/12/31 PhasAGE - Excellence Hub on Phase Transitions in Aging and Age-Related Disorders
H2020-WIDESPREAD-2020-5
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 European Union
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
UIDP/04378/2020
10.54499/UIDP/04378/2020
Researcher
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2022/09/01 - 2023/09/30 Consequences of axonal demyelination for mitochondria biology
Mddemy-GI2-CESPU-2022
Principal investigator
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2018/07/01 - 2021/06/30 Molecular mechanisms of the dynein-dynactin transport machinery in health and disease
PTDC/BIA-CEL/30507/2017
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/03/01 - 2013/11/30 Implications of amphetamine psychostimulants abuse in brain ageing
PTDC/SAU-FCF/102958/2008
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Coimbra, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Barbosa, Daniel José; Carvalho, Félix; Carmo, Helena. "The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines". In Mitochondrial Intoxication. United States: Elsevier, 2023.
    Published
  2. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Bastos, Maria de Lourdes; Carvalho, F.. "Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction". In Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants, 487-508. Jersey City, United States: John Wiley & Sons, Inc., 2018.
    Published
  3. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; De Lourdes Bastos, M.; Carvalho, E.. "Mitochondrial Trails in the Neurotoxic Mechanisms of MDMA". In Neuropathology of Drug Addictions and Substance Misuse, edited by Victor R. Preedy. Elsevier, 2016.
    Published • 10.1016/B978-0-12-800212-4.00040-6
Conference abstract
  1. Costa, Inês; Martins, Márcia; Barbosa, Daniel José; Sousa, Maria Emília; Silva, Renata. "Fiscalin Derivatives Exhibit Dual Neuroprotective Activity Against Aß Toxicity and Iron Damage in Alzheimer’s Disease". Paper presented in 3rd Symposium on Alzheimer’s disease: an update on pathology and therapeutics, Porto, 2025.
    Published
  2. Maria J. Teixeira; Freitas, Ana R; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "Bacterial load and dynamics: exploring their potential as biomarkers for postmortem interval estimation". 2025.
    Published
  3. Gil-Martins, E.; F. Cagide-Fagín; A. Borer; Barbosa, DJ; Carlos Fernandes; Fernando Remião; Borges, Fernanda; Silva, Renata. "Insights into the mechanistic pathways underlying the neurotoxic effects of 2C-I and 25I-NBOMe drugs". Paper presented in 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Copenhagen, 2024.
    Published
  4. Gil-martins, E.; Cagide, F.; Borer, A.; Barbosa, D.J.; Fernandes, C.; Remião, F.; Borges, F.; Silva, Renata. Corresponding author: Silva, Renata. "P04-08 Insights into the mechanistic pathways underlying the neurotoxic effects of 2C-I and 25I-NBOMe drugs". 2024.
    10.1016/j.toxlet.2024.07.335
  5. Ana Cláudia-Ferreira; Barbosa, DJ; Carla Campos; Dinis-Oliveira, Ricardo Jorge; Ana R. Freitas. "Mapping of key bacterial species for postmortem interval calculation". Paper presented in III 1H-TOXRUN INTERNATIONAL CONGRESS, Porto, 2024.
    Published
  6. Silva, R.; Barbosa, D.J.; Carmo, H.; Carvalho, F.; da Silva, D. Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "P21-18: The impact of ADB-FUBINACA on the differentiation, maturation and astrocyte activation in in vitro primary hippocampal cultures". Paper presented in EUROTOX 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00825-1
  7. Gil-Martins, Eva; Cagide, Fernando; Borer A; Barbosa, DJ; Martins D; Fernandes C; Remião, Fernando; Borges F; Renata Silva. "Mechanisms behind the neurotoxicity of 2C-I and 25I-NBOMe drugs". Paper presented in II Toxrun International Congress, Porto, 2023.
    Published
  8. Barbosa, Daniel José. "The synthetic cannabinoid THJ-2201 increases the differentiation of primary hippocampal neurons and early astrocyte activation but decreases neuronal maturation". Paper presented in The XVI Internatonal Congress of Toxicology, Maastricht, 2022.
    Published
  9. Bravo, R. Roque; Barbosa, D. J.; Carmo, H.; Silva, J. P.; Carvalho, F.; Da Silva, D. Dias. "The influence of selected synthetic cannabinoids on in vitro proliferation and viability of neuronal cell models". Paper presented in XVIth International Congress of Toxicology (ICT 2022), Maastricht, 2022.
    Published • 10.1016/J.TOXLET.2022.07.163
  10. Ana Cláudia-Ferreira; Barbosa, Daniel José; Dinis-Oliveira, Ricardo Jorge; Ana Raquel Freitas. "Current perspective on the relevance of bacterial communities to estimate post-mortem intervals - how far are we?". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, Porto, 2022.
    Published
  11. Roque Bravo, Rita; Barbosa, Daniel José; Carmo, Helena; João Pedro Silva; Carvalho, Félix; Diana Dias da Silva. "Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 impact on in vitro viability and proliferation of primary rat hippocampal neurons and SH-SY5Y cells". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, Porto, 2022.
    Published
  12. Gil-Martins, E.; Barbosa, D. J.; Sousa, E.; Resende, D.; Remiao, F.; Silva, R.. "P-glycoprotein modulation by xanthonic derivatives: a strategy to fight Alzheimer's disease". Paper presented in 55th Congress of the European Societies of Toxicology (EUROTOX 2019), Helsinki, 2019.
    Published
  13. Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Silva, R.. "Newly synthetized xanthonic derivatives as potential P-glycoprotein modulators: a strategy to fight Alzheimer¿s disease". Paper presented in 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2019.
    Published
  14. Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Silva, R.. "In vitro modulation of P-glycoprotein by xanthonic derivates: implications on Alzheimer's disease". Paper presented in SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2019.
    Published
  15. Duro, J.; Gama, J. B.; Barbosa, D. J.; Carvalho, C.; Celestino, R.; Carvalho, A. X.; Gassmann, R.. "A C. elegans dynactin p150 mutant with reduced affinity for dynein intermediate chain uncouples dynein recruitment from dynein activation". Paper presented in In ASCB|EMBO Annual Meeting, San Diego, 2018.
    Published
  16. Silva, R.; Carmo, H.; Vilas-Boas, V.; Barbosa, D. J.; Palmeira, A.; Sousa, E.; Bastos, Maria de Lourdes; Remião, Fernando. "Hypericin-mediated P-glycoprotein induction protects caco-2 cells against paraquat toxicity: In vitro and in silico studies". Porto, 2015.
    Published • 10.1016/J.TOXLET.2015.08.905
  17. Feio-Azevedo, R.; Costa, Vera Marisa; Gomes, Ana; Pita, Inês; Sequeira, A; Pereira, Frederico; Duarte-Araújo, M.; et al. "Aged rats are more prone to ecstasy neurotoxicity than adolescent rats". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published
  18. Silva, Renata; Gameiro, Mariline; Sousa, Emilia; Carmo, Helena; Paiva, AM; Barbosa, Daniel José (FE1C-104F-37C1); Pinto, Madalena; Bastos, Maria de Lourdes; Remião, Fernando. "New thioxanthones and dihydroxylated xanthones as P-glycoprotein inducers/activators". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published
  19. Arbo, Marcelo; Silva, Renata; Barbosa, Daniel José (FE1C-104F-37C1); Dias da Silva, Diana; Bastos, Maria de Lourdes; Carmo, Helena. "Piperazine designer drugs are cytotoxic to human neuroblastoma SH-SY5Y cells". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published
  20. Azevedo, Rita; Costa, Vera M.; Barbosa, Daniel; Gomes, Armanda; Pita, Ines; Sequeira, Ana; Pereira, Frederico; et al. "Aged rats are more prone to "ecstasy" neurotoxicity than adolescent rats". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published • 10.1016/J.TOXLET.2014.06.804
  21. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, Romàn; Mirra, Serena; Quevedo, Martí; Barreda, Elena Gomes; Àvila, Jesus; Fernandes, Eduarda; et al. ""Ecstasy" impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), Interlaken, 2013.
    Published
  22. Remião, Fernando; Silva, Renata; Vilas-Boas, Vânia; Barbosa, Daniel José (FE1C-104F-37C1); Palmeira, Andreia; Sousa, Emília; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena. "P-glycoprotein expression and activity are differently modulated by Colchicine in Caco-2 cells: In vitro and in silico studies.". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), Interlaken, 2013.
    Published
  23. Barbosa, Daniel Jose; Capela, Joao Paulo; Ferreira, Luisa Maria; Branco, Paula; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Felix; et al. "Mixture of "Ecstasy" and its metabolites are toxic to SH-SY5Y differentiated cells". Paper presented in 48th Congress of the European Societies of Toxicology (EUROTOX), Estocolmo, 2012.
    Published • 10.1016/J.TOXLET.2012.03.688
  24. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Oliveira, Jorge Miguel Ascenção; Ferreira, Luisa; Branco, Paula; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Félix. "Pro-oxidant effects of "ecstasy" and its metabolites in mouse brain synaptosomes". Paper presented in 47th Congress of the European Societies of Toxicology (EUROTOX), Paris, 2011.
    Published
  25. José Barbosa, Daniel; Ferreira, Luisa; Branco, Paula; Fernandes, Eduarda; Carmo, Helena; Remião, Fernando; Bastos, Maria de Loudes; et al. "Evaluation of the oxidative damage induced by MDMA and its metabolites in rat brain synaptosomes". Paper presented in XII International Congress of Toxicology (IUTOX), Barcelona, 2010.
    Published
  26. Barbosa, D. J.; Ferreira, L.; Serio Branco, P.; Fernandes, E.; Carmo, H.; Remiao, F.; Bastos, M. L.; et al. "Evaluation of the oxidative damage induced by MDMA and its metabolites in rat brain synaptosomes". 2010.
    10.1016/J.TOXLET.2010.03.765
Conference poster
  1. Silva-Carvalho, Mariana; Barbosa, Daniel José; Dias da Silva, Diana; Dinis-Oliveira, Ricardo Jorge. "Lisdexamfetamine: an over(re)view". Paper presented in XX Colóquio de Farmácia: De Pharmacia a Farmácia, 2025.
  2. Ivo Lacerda; Barbosa, DJ. "The hepatotoxicity of nimesulide reflected in fatal and non-fatal intoxications". Paper presented in VI Congress of the Portuguese Association of Forensic Sciences, 2024.
  3. Ivo Lacerda; Manuela Oliveira; Barbosa, D.J.. "Genotoxicity of the non-steroidal anti-inflammatory drugs naproxen and nimesulide". Paper presented in XXII Portuguese Congress of Legal Medicine and Forensic Sciences, 2024.
  4. Moyisyeyenko, Tatiana; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "Intoxications and fatalities involving new psychoactive substances in 2023 and the influence of ethanol". Paper presented in XXII Portuguese Congress of Legal Medicine and Forensic Sciences, 2024.
  5. Gil-Martins, E.; Cagide, Fernando; Ana Borer; Barbosa, DJ; Fernandes, Carlos; Remião F; Fernanda Borges; Renata Silva. "Insights into the mechanistic pathways underlying the neurotoxic effects of 2C-I and 25I-NBOMe drugs.". Paper presented in III 1H-TOXRUN INTERNATIONAL CONGRESS, 2024.
  6. Cláudia-Ferreira A; Barbosa, DJ; Carla Campos; Dinis-Oliveira, Ricardo Jorge; Ana Raquel Freitas. "Mapping of key bacterial species for Postmortem interval calculation". Paper presented in III 1H-TOXRUN INTERNATIONAL CONGRESS, 2024.
  7. Silva, Rafaela; Barbosa, Daniel José; Carmo, Helena; Carvalho, Félix; da Silva, D. Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "The impact of ADB-FUBINACA on the differentiation, maturation and astrocyte activation in in vitro primary hippocampal cultures.". Paper presented in EUROTOX 2023, 2023.
  8. Gil-Martins, Eva; Cagide, Fernando; Borer A; Barbosa, DJ; Martins D; Fernandes C; Remião, Fernando; Borges F; Renata Silva. "Mechanisms behind the neurotoxicity of 2C-I and 25I-NBOMe drugs". Paper presented in II Toxrun International Congress, 2023.
  9. Remiao, Fernando; Silva, Renata; Vilas-Boas, Vania; Barbosa, Daniel Jose; Palmeira, Andreia; Sousa, Emilia; Carvalho, Felix; Bastos, Maria de Lourdes; Carmo, Helena. "P-glycoprotein expression and activity are differently modulated by Colchicine in Caco-2 cells: In vitro and in silico studies". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), 2023.
    10.1016/J.TOXLET.2013.05.401
  10. Carvalho, Cátia; Barbosa, Daniel José; Gassmann, Reto. "Dynein-1 and cell shape work together to ensure proper tissue architecture of the Caenorhabditis elegans epidermis". Paper presented in 5th PhDay – “Building Paths: The Science Behind Us”, 2022.
  11. Barbosa, Daniel José. "The synthetic cannabinoid THJ-2201 increases the differentiation of primary hippocampal neurons and early astrocyte activation but decreases neuronal maturation". Paper presented in The XVI Internatonal Congress of Toxicology, 2022.
  12. Barbosa, Daniel José. "The influence of selected synthetic cannabinoids on in vitro proliferation and viability of neuronal cell models". Paper presented in The XVI Internatonal Congress of Toxicology, 2022.
  13. Eva Gil Martins; F. Cagide-Fagín; Barbosa, Daniel José; Daniel Martins; Carlos Fernandes; Fernando Remião; Fernanda Borges; Renata Silva. "Neurotoxic profile of psychedelic phenethylamine derivatives.". Paper presented in MedChem22 (X Meeting of the Paul Ehrlich Euro-PhD Network), 2022.
  14. Ana Cláudia-Ferreira; Barbosa, Daniel José; Dinis-Oliveira, Ricardo Jorge; Ana Raquel Freitas. "Current perspective on the relevance of bacterial communities to estimate post-mortem intervals - how far are we?". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  15. Roque Bravo, Rita; Barbosa, Daniel José; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 impact on in vitro viability and proliferation of primary rat hippocampal neurons and SH-SY5Y cells". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  16. Duro, Joana; Gama, José Bernardo; Barbosa, Daniel José (FE1C-104F-37C1); Carvalho, Cátia; Gassmann, Reto. "A C. elegans dynactin p150 mutant with reduced affinity for dynein intermediate chain uncouples dynein recruitment from dynein activation". Paper presented in ASCB|EMBO Annual Meeting, 2018.
  17. Marins, Eva; Barbosa, Daniel José (FE1C-104F-37C1); Palmeira, Andreia; Sousa, Emilia; Lemos, A; Carmo, Helena; Pinto, Madalena; et al. "P-gp induction and activation by newly synthesized xanthonic derivatives as a potential therapeutic approach in intoxications and neurological diseases". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry 2018, 2018.
  18. Carvalho, Cátia; Celestino, Ricardo; Gama, José Bernardo; Barbosa, Daniel José (FE1C-104F-37C1); Gassmann, Reto. "A short helix in the C-terminal region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". Paper presented in EMBO Workshop: C. elegans development, cell biology and gene expression, 2018.
  19. Duro, Joana; Barbosa, Daniel José (FE1C-104F-37C1); Gassmann, Reto. "Characterization of a p150/DNC-1 mutant that uncouples dynactin’s role in dynein recruitment from its role in dynein activation". Paper presented in EMBO Workshop: C. elegans development, cell biology and gene expression, 2018.
  20. Celestino, Ricardo; Gama, José Bernardo; Henen, M; Carvalho, Cátia; Barbosa, Daniel José (FE1C-104F-37C1); Vögeli, B.; Gassmann, Reto. "A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". Paper presented in EMBO/EMBL Symposium: Microtubules: From Atoms to Complex Systems, 2018.
  21. Barbosa, Daniel José (FE1C-104F-37C1); Silva, Tânia Magalhães; Fernendes, Joana; Simões, Patricia Alexandra; Gassmann, Reto. "Dissecting the mitotic functions of dynactin in the early C. elegans embryo". Paper presented in EMBO/EMBL Symposium: Microtubules: From Atoms to Complex Systems, 2016.
  22. Silva, Renata; Palmeira, A.; Carmo, H.; Barbosa, DJ; Gameiro, M.; Sousa, E.; Pinto, M.; Bastos, M.L.; Remião, Fernando. "P-glycoprotein induction by newly synthetized (thio)xanthones prevents Paraquat cytotoxicity.". Paper presented in 55th Annual Meeting and ToxExpo, March 13-17 2016, NewOrleans, Louisiana, USA., 2016.
  23. Silva, Renata; Carmo, Helena; Vilas-Boas, Vânia; Palmeira, Andreia; Sousa, Emilia; Bastos, Maria de Lourdes; Remião, Fernando. "Hypericin-mediated P-glycoprotein induction protects caco-2 cells against paraquat toxicity: in vitro and in silico studies". Paper presented in 51st Congress of the European Societies of Toxicology (EUROTOX), 2015.
  24. Feio-Azevedo, Rita; Costa, Vera Marisa; Gomes, A; Pita, Inês; Sequira, A; Pereira, Frederico; Duarte-Araújo, Margarida; et al. "Aged rats are more prone to “ecstasy” neurotoxicity than adolescent rats". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), 2014.
  25. Arbo, Marcelo; Silva, Renata; Silva, Diana Dias; Bastos, Maria de Lourdes; Carmo, Helena. "Piperazine designer drugs are cytotoxic to human neuroblastoma SH-SY5Y cells". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), 2014.
  26. Silva, Renata; Gameiro, Mariline; Sousa, Emília; Carmo, Helena; Paiva, Ana Mafalda; Barbosa, Daniel José (FE1C-104F-37C1); Pinto, Madalena; Bastos, Maria de Lourdes; Remião, Fernando. "New thioxanthones and dihydroxylated xanthones as P-glycoprotein inducers/activators". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), 2014.
  27. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, Romàn; Mirra, Serena; Quevedo, Martí; Barreda, EG; Àvila, Jesus; Fernandes, Eduarda; et al. "Ecstasy impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), 2013.
    10.1158/1538-7445.am2019-1480
  28. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Silva, Renata; Ferreira, Luísa Maria ; Branco, Paula Sério; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Félix. "The mixture of "Ecstasy" and its metabolites, at low concentrations, is toxic to SH-SY5Y differentiated cells". Paper presented in 48th Congress of the European Societies of Toxicology (EUROTOX), 2012.
  29. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Oliveira, Jorge Miguel Ascenção; Silva, Renata; Ferreira, Luísa Maria ; Siopa, Filipa; Branco, Paula Sério; et al. "Pro-oxidant effects of "ecstasy" and its metabolites in mouse brain synaptosomes". Paper presented in 47th Congress of the European Societies of Toxicology (EUROTOX), 2011.
  30. Barbosa, Daniel José; Capela, João Paulo; Oliveira, Jorge Miguel Ascenção; Silva, Renata; Ferreira, Luísa Maria ; Branco, Paula Sério; Fernandes, Eduarda; et al. "Pro-oxidant effects of "Ecstasy" and its metabolites in mouse brain synaptosomes". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  31. Barbosa, Daniel José; Ferreira, Luísa Maria ; Branco, Paula Sério; Fernandes, Eduarda; Carmo, Helena; Remião, Fernando; Bastos, Maria de Lourdes; et al. "Evaluation of the oxidative damage induced by MDMA and its metabolites in rat brain synaptosomes". Paper presented in XII International Congress of Toxicology (IUTOX), 2010.
  32. Soares, Helena; Caetano, Susana; Barbosa, Daniel José (FE1C-104F-37C1); Areias, Cristiana. "Utilização de Antídotos no Centro Hospitalar do Porto - Hospital de Santo António". Paper presented in XIII Simpósio da Associação Portuguesa de Farmacêuticos Hospitalares, 2009.
  33. Barbosa, Daniel José (FE1C-104F-37C1); Cardoso, Ricardo; Pereira, Ricardo. "Estudo das interferências das cumarinas naturais ingeridas na dieta na terapêutica anticoagulante oral com varfarina". Paper presented in I Meeting of Human Food, IV Meeting of Pharmaceutical Chemistry, 2008.
Journal article
  1. Barbosa, Daniel José; Santos, Inês C.; Moyisyeyenko, Tatiana; Mendes, Cristina; Sobral, Ana Filipa. "C. elegans as a powerful model for neurotoxicity assessment". NeuroToxicology 110 (2025): 85-110. https://doi.org/10.1016/j.neuro.2025.07.009.
    10.1016/j.neuro.2025.07.009
  2. Ana Filipa Sobral; Andrea Cunha; Inês Costa; Mariana Silva-Carvalho; Renata Silva; Daniel José Barbosa. "Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease". Journal of Xenobiotics (2025): https://doi.org/10.3390/jox15040118.
    10.3390/jox15040118
  3. Ferreira, Luís Filipe Leão Carvalho; Barbosa, Daniel José; Dinis-Oliveira, Ricardo Jorge. "The toxicology of greater weever (Trachinus draco): Clinical and forensic aspects". Toxicon 265 (2025): 108492. https://doi.org/10.1016/j.toxicon.2025.108492.
    Published • 10.1016/j.toxicon.2025.108492
  4. Gil-Martins, Eva; Barbosa, Daniel José; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Toxicodynamic insights of 2C and NBOMe drugs – Is there abuse potential?". Toxicology Reports 14 (2025): 101890. https://doi.org/10.1016/j.toxrep.2025.101890.
    10.1016/j.toxrep.2025.101890
  5. Eva Gil-Martins; Daniel José Barbosa; Fernando Cagide; Fernando Remião; Fernanda Borges; Renata Silva. "Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs Impact Caenorhabditis elegans Development and Reproductive Behavior". International Journal of Molecular Sciences (2025): https://doi.org/10.3390/ijms26073039.
    10.3390/ijms26073039
  6. Ana Filipa Sobral; Inês Costa; Vanessa Teixeira; Renata Silva; Daniel José Barbosa. "Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes". Brain Sciences (2025): https://doi.org/10.3390/brainsci15030279.
    10.3390/brainsci15030279
  7. Costa Alegre, Mariana Duarte; Barbosa, Daniel José; Dinis-Oliveira, Ricardo Jorge. "Metabolism of m-CPP, trazodone, nefazodone, and etoperidone: clinical and forensic aspects". Drug Metabolism Reviews (2025): 1-44. https://doi.org/10.1080/03602532.2025.2465482.
    Published • 10.1080/03602532.2025.2465482
  8. Eva Gil-Martins; Fernando Cagide; Ana Borer; Daniel José Barbosa; Carlos Fernandes; Daniel Chavarria; Fernando Remião; Fernanda Borges; Renata Silva. "The Role of Mitochondrial Dysfunction and Calcium Dysregulation in 2C-I and 25I-NBOMe-Induced Neurotoxicity". Chemico-Biological Interactions (2025): https://doi.org/10.1016/j.cbi.2025.111425.
    10.1016/j.cbi.2025.111425
  9. Cristina Mendes; Daniela Maia; Ricardo Jorge Dinis-Oliveira; Fernando Remião; Renata Silva; Daniel José Barbosa. "Synthetic cathinones induce developmental arrest, reduce reproductive capacity, and shorten lifespan in the C. elegans model". Journal of Xenobiotics (2025): https://doi.org/10.3390/jox15010033.
    Accepted • 10.3390/jox15010033
  10. Carvalho, Cátia; Moreira, Matilde; Barbosa, Daniel J.; Chan, Fung-Yi; Koehnen, Carlota Boal; Teixeira, Vanessa; Rocha, Helder; et al. "ZYG-12/Hook's dual role as a dynein adaptor for early endosomes and nuclei is regulated by alternative splicing of its cargo binding domain". Molecular Biology of the Cell (2024): https://doi.org/10.1091/mbc.e24-08-0364.
    Published • 10.1091/mbc.e24-08-0364
  11. Barbosa, Daniel José; Barbosa, Joana; Souza-Fagundes, Elaine M.; Silva, Patrícia M. A.. "The (un)desirability of cell death in health and disease: emerging modulators and their mechanisms". Frontiers in Cell and Developmental Biology 12 (2024): https://doi.org/10.3389/fcell.2024.1523293.
    Published • 10.3389/fcell.2024.1523293
  12. Silva, Renata; Sobral, Ana Filipa; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "The Link Between Paraquat and Demyelination: A Review of Current Evidence". Antioxidants 13 11 (2024): 1354. https://doi.org/10.3390/antiox13111354.
    10.3390/antiox13111354
  13. Daniel José Barbosa; Cátia Carvalho; Inês Costa; Renata Silva. "Molecular Motors in Myelination and Their Misregulation in Disease". Molecular Neurobiology (2024): https://doi.org/10.1007/s12035-024-04576-9.
    Published • 10.1007/s12035-024-04576-9
  14. Sobral, Ana Filipa; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "CRISPR-Cas technology in forensic investigations: Principles, applications, and ethical considerations". Forensic Science International: Genetics 74 (2024): 103163. https://doi.org/10.1016/j.fsigen.2024.103163.
    Open access • Published • 10.1016/j.fsigen.2024.103163
  15. Ana Filipa Sobral; Andrea Cunha; Vera Silva; Eva Gil-Martins; Renata Silva; Daniel José Barbosa. "Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25179339.
    Published • 10.3390/ijms25179339
  16. Eva Gil-Martins; Fernando Cagide-Fagín; Daniel Martins; Ana Borer; Daniel José Barbosa; Carlos Fernandes; Daniel Chavarria; et al. "Mechanistic Insights into the Neurotoxicity of 2,5-Dimethoxyphenethylamines (2C) and Corresponding N-(2-methoxybenzyl)phenethylamine (NBOMe) Drugs". Journal of Xenobiotics (2024): https://doi.org/10.3390/jox14020044.
    10.3390/jox14020044
  17. Inês C. Santos; Daniela Maia; Ricardo Jorge Dinis-Oliveira; Daniel José Barbosa. "New Psychoactive Substances: Health and Legal Challenges". Psychoactives (2024): https://doi.org/10.3390/psychoactives3020018.
    Published • 10.3390/psychoactives3020018
  18. Monteiro, Ana Rita; Barbosa, Daniel José; Remião, Fernando; Silva, Renata. "Co-Culture Models: Key Players in In Vitro Neurotoxicity, Neurodegeneration and BBB Modeling Studies". Biomedicines 12 3 (2024): 626. https://doi.org/10.3390/biomedicines12030626.
    Published • 10.3390/biomedicines12030626
  19. Cátia Carvalho; Daniel J Barbosa; Ricardo Celestino; Esther Zanin; Ana Xavier Carvalho; Reto Gassmann; M Boxem. "Dynein directs prophase centrosome migration to control the stem cell division axis in the developing Caenorhabditis elegans epidermis". GENETICS (2024): https://doi.org/10.1093/genetics/iyae005.
    10.1093/genetics/iyae005
  20. Gil-Martins, Eva; Cagide-Fagin, Fernando; Daniel Martins; Ana Borer; Barbosa, Daniel José; Carlos Fernandes; Chavarria, Daniel; et al. "Mechanistic insights into the neurotoxicity of 2C-T-X and 25TX-NBOMe drugs". Xenobiotics (2024):
    Submitted
  21. Dinis-Oliveira, Ricardo Jorge; Dias da Silva, Diana; Barbosa, Daniel José; Silva-Carvalho, Mariana. "Pharmacological, Clinical Applications, and Forensic Aspects of Lisdexamfetamine", to European Journal of Drug Metabolism and Pharmacokinetics". European Journal of Drug Metabolism and Pharmacokinetics (2024):
    Submitted
  22. Pinto, Bárbara; Silva, João P. N.; Silva, Patrícia M. A.; Barbosa, Daniel José; Sarmento, Bruno; Tavares, Juliana Carvalho; Bousbaa, Hassan. "Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction". Pharmaceutics 16 1 (2023): 56. http://dx.doi.org/10.3390/pharmaceutics16010056.
    Published • 10.3390/pharmaceutics16010056
  23. Ana Cláudia-Ferreira; Daniel José Barbosa; Veroniek Saegeman; Amparo Fernández-Rodríguez; Ricardo Jorge Dinis-Oliveira; Ana R. Freitas. "The future is now: unraveling the expanding potential of human (necro)microbiome in forensic investigations". Microorganisms (2023): https://doi.org/10.3390/microorganisms11102509.
    Published • 10.3390/microorganisms11102509
  24. Monteiro, Ana R.; Barbosa, Daniel J.; Remião, Fernando; Silva, Renata. "Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs". Biochemical Pharmacology 211 (2023): 115522. https://doi.org/10.1016/j.bcp.2023.115522.
    10.1016/j.bcp.2023.115522
  25. Inês Costa; Daniel José Barbosa; Vera Silva; Sofia Benfeito; Fernanda Borges; Fernando Remião; Renata Silva. "Research Models to Study Ferroptosis Impact in Neurodegenerative Diseases". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15051369.
    Published • 10.3390/pharmaceutics15051369
  26. Costa, Inês; Barbosa, Daniel José; Benfeito, Sofia; Silva, Vera; Chavarria, Daniel; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Molecular mechanisms of ferroptosis and their involvement in brain diseases". Pharmacology & Therapeutics 244 (2023): 108373. https://doi.org/10.1016/j.pharmthera.2023.108373.
    Published • 10.1016/j.pharmthera.2023.108373
  27. Daniel José Barbosa; João Paulo Capela; Luísa Maria Ferreira; Paula Sério Branco; Eduarda Fernandes; Maria de Lourdes Bastos; Félix Carvalho. "Ecstasy metabolites and monoamine neurotransmitters upshift the Na+/K+ ATPase activity in mouse brain synaptosomes". Archives of Toxicology (2022): https://doi.org/10.1007/s00204-022-03370-7.
    Published • 10.1007/s00204-022-03370-7
  28. Ricardo Celestino; José Gama; Artur Castro-Rodrigues; Barbosa, Daniel José; Helder Rocha; Ennio d'Amico; Andrea Musacchio; et al. "JIP3 interacts with dynein and kinesin-1 to regulate bi-directional organelle transport". Journal of Cell Biology (2022): https://doi.org/10.1083/jcb.202110057.
    Published • 10.1083/jcb.202110057
  29. Ana Filipa Sobral; Fung-Yi Chan; Michael J. Norman; Daniel S. Osório; Ana Beatriz Dias; Vanessa Ferreira; Daniel J. Barbosa; et al. "Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis". Current Biology (2021): https://doi.org/10.1016/j.cub.2021.09.055.
    Published • 10.1016/j.cub.2021.09.055
  30. Barbosa, Daniel J.; Teixeira, Vanessa; Duro, Joana; Carvalho, Ana X.; Gassmann, Reto. "Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes". Development 148 3 (2021): http://dx.doi.org/10.1242/dev.197780.
    Published • 10.1242/dev.197780
  31. Gil-Martins, Eva; Barbosa, Daniel José; Silva, Vera; Remião, Fernando; Silva, Renata. "Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders". Pharmacology & Therapeutics (2020): 107554. http://dx.doi.org/10.1016/j.pharmthera.2020.107554.
    Published • 10.1016/j.pharmthera.2020.107554
  32. Celestino, R.; Henen, M.A.; Gama, J.B.; Carvalho, C.; McCabe, M.; Barbosa, Daniel José (FE1C-104F-37C1); Born, A.; et al. "A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". PLoS Biology 17 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060185140&partnerID=MN8TOARS.
    Published • 10.1371/journal.pbio.3000100
  33. Feio-Azevedo, R.; Costa, Vera Marisa; Barbosa, Daniel José (FE1C-104F-37C1); Teixeira-Gomes, A.; Pita, I.; Gomes, S.; Pereira, F.C.; et al. "Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity". Archives of Toxicology 92 7 (2018): 2275-2295. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047997081&partnerID=MN8TOARS.
    Published • 10.1007/s00204-018-2226-8
  34. Barbosa, Daniel José (FE1C-104F-37C1); Duro, J.; Prevo, B.; Cheerambathur, D.K.; Carvalho, A.X.; Gassmann, R.. "Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport". PLoS Genetics 13 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85026624927&partnerID=MN8TOARS.
    Published • 10.1371/journal.pgen.1006941
  35. Gama, J.B.; Pereira, C.; Simões, P.A.; Celestin, R.; Reis, R.M.; Pires, H.R.; Carvalho, C.; et al. "Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly". Journal of Cell Biology 216 4 (2017): 943-960. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021847678&partnerID=MN8TOARS.
    Published • 10.1083/jcb.201610108
  36. Arbo, M.D.; Silva, Renata; Barbosa, Daniel José; da Silva, D.D.; Silva, S.P.; Teixeira, J.P.; Bastos, M.L.; Carmo, H.. "In vitro neurotoxicity evaluation of piperazine designer drugs in differentiated human neuroblastoma SH-SY5Y cells". Journal of Applied Toxicology 36 1 (2016): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952636464&partnerID=MN8TOARS.
    Published • 10.1002/jat.3153
  37. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; Feio-Azevedo, R.; Teixeira-Gomes, A.; Bastos, M.L.; Carvalho, F.. "Mitochondria: key players in the neurotoxic effects of amphetamines". Archives of Toxicology 89 10 (2015): 1695-1725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942195353&partnerID=MN8TOARS.
    Published • 10.1007/s00204-015-1478-9
  38. Silva, R.; Palmeira, A.; Carmo, H.; Gameiro, M.; Gomes, A.; Paiva, A.M.; Sousa, E.; et al. "P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity". Archives of Toxicology 89 10 (2015): 1783-1800. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942198190&partnerID=MN8TOARS.
    Published • 10.1007/s00204-014-1333-4
  39. Silva, R.; Carmo, H.; Vilas-Boas, V.; Barbosa, Daniel José (FE1C-104F-37C1); Monteiro, M.; de Pinho, P.G.; de Lourdes Bastos, M.; Remião, F.. "Several transport systems contribute to the intestinal uptake of Paraquat, modulating its cytotoxic effects". Toxicology Letters 232 1 (2015): 271-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911457479&partnerID=MN8TOARS.
    Published • 10.1016/j.toxlet.2014.10.015
  40. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; De Lourdes Bastos, M.; Carvalho, F.. "In vitro models for neurotoxicology research". Toxicology Research 4 4 (2015): 801-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935015349&partnerID=MN8TOARS.
    Published • 10.1039/c4tx00043a
  41. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, R.; Mirra, S.; Quevedo, M.; de Barreda, E.G.; Àvila, J.; Luísa Maria Ferreira; et al. "The mixture of "ecstasy" and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations". Toxicological Sciences 139 2 (2014): 407-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899939292&partnerID=MN8TOARS.
    Published • 10.1093/toxsci/kfu042
  42. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, R.; Mirra, S.; Quevedo, M.; Gómez De Barreda, E.; Ávila, J.; Fernandes, E.; et al. "MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner". Archives of Toxicology 88 8 (2014): 1561-1572. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905002125&partnerID=MN8TOARS.
    Published • 10.1007/s00204-014-1209-7
  43. Arbo, M.D.; Silva, R.; Barbosa, Daniel José (FE1C-104F-37C1); da Silva, D.D.; Rossato, L.G.; Bastos, M.D.L.; Carmo, H.. "Piperazine designer drugs induce toxicity in cardiomyoblast h9c2 cells through mitochondrial impairment". Toxicology Letters 229 1 (2014): 178-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903629417&partnerID=MN8TOARS.
    Published • 10.1016/j.toxlet.2014.06.031
  44. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; Silva, R.; Ferreira, L.M.; Branco, P.S.; Fernandes, E.; Bastos, M.L.; Carvalho, F.. "Ecstasy-induced toxicity in SH-SY5Y differentiated cells: Role of hyperthermia and metabolites". Archives of Toxicology 88 2 (2014): 515-531. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893906917&partnerID=MN8TOARS.
    Published • 10.1007/s00204-013-1147-9
  45. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; Silva, R.; Vilas-Boas, V.; Ferreira, L.M.; Branco, P.S.; Fernandes, E.; Bastos, M.D.L.; Carvalho, F.. "The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations". Archives of Toxicology 88 2 (2014): 455-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893949148&partnerID=MN8TOARS.
    Published • 10.1007/s00204-013-1120-7
  46. Silva, R.; Carmo, H.; Vilas-Boas, V.; Barbosa, Daniel José (FE1C-104F-37C1); Palmeira, A.; Sousa, E.; Carvalho, F.; De Lourdes Bastos, M.; Remião, F.. "Colchicine effect on P-glycoprotein expression and activity: In silico and in vitro studies". Chemico-Biological Interactions 218 (2014): 50-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901254592&partnerID=MN8TOARS.
    Published • 10.1016/j.cbi.2014.04.009
  47. Silva, R.; Sousa, E.; Carmo, H.; Palmeira, A.; Barbosa, Daniel José (FE1C-104F-37C1); Gameiro, M.; Pinto, M.; De Lourdes Bastos, M.; Remião, F.. "Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat". Archives of Toxicology 88 4 (2014): 937-951. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897110064&partnerID=MN8TOARS.
    Published • 10.1007/s00204-014-1193-y
  48. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, Romàn; Ferreira, Luísa Maria; Branco, Paula Sério; Bastos, Maria de Lourdes; Capela, João Paulo; Soriano, Eduardo; Carvalho, Félix. "Neuronal Mitochondrial Trafficking Impairment: The Cause or a Consequence of Neuronal Dysfunction Caused by Amphetamine-Like Drugs". Journal of Drug and Alcohol Research 3 (2014): 1-7. http://dx.doi.org/10.4303/jdar/235868.
    Published • 10.4303/jdar/235868
  49. Barbosa, Daniel José; Capela, João Paulo; Oliveira, Jorge MA; Silva, Renata; Ferreira, Luísa Maria; Siopa, Filipa; Branco, Paula Sério; et al. "Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes". British Journal of Pharmacology 165 4b (2012): 1017-1033. https://doi.org/10.1111/j.1476-5381.2011.01453.x.
    10.1111/j.1476-5381.2011.01453.x
Journal issue
  1. Barbosa, Daniel José; Sobral, Ana Filipa; Silva, Renata; Dinis-Oliveira, Ricardo Jorge. "New Psychoactive Substances and Emerging Trends: Pharmacology, Neurotoxicity, and Public Health Implications". Psychoactives & International Journal of Molecular Sciences (2026):
    Submitted • Invited editor
  2. Barbosa, DJ; Sobral, Ana Filipa. "Cellular and molecular mechanisms regulating neuronal function, homeostasis, and disease". Brain Sciences (2025): https://www.mdpi.com/journal/brainsci/special_issues/M6L3X70WW5.
    Published • Invited editor
  3. Barbosa, Daniel José; Renata Silva. "Drug-induced neurotoxicity and neurodegeneration: Mechanisms, models and implications". International Journal of Molecular Sciences (2025): https://www.mdpi.com/journal/ijms/special_issues/4QNY3F411K.
    Published • Invited editor
  4. Barbosa, Daniel José; Silva, Renata. "Molecular and cellular advances on drug discovery, pharmacology and toxicology, 2nd Edition". Medicina (2025): https://www.mdpi.com/journal/medicina/special_issues/9BI035U1YQ.
    Published • Invited editor
  5. Patrícia Silva; Barbosa, Daniel José; Elaine Maria Souza-Fagundes. "The (un)desirability of cell death in health and disease: Emerging modulators and their mechanisms". Frontiers in Cell and Development Biology (2024): https://www.frontiersin.org/research-topics/57035/the-undesirability-of-cell-death-in-health-and-disease-emerging-modulators-and-their-mechanisms.
    Published • Coeditor
  6. Silva, Renata; Barbosa, Daniel José. "New insights on drug design, delivery and targeting in neurodegeneration". Pharmaceutics (2023): https://www.mdpi.com/journal/pharmaceutics/special_issues/drug_neurodegeneration.
    Published • Coeditor
  7. Barbosa, Daniel José; Liliana Luz. "Mechanisms of myelin misregulation and neuronal dysfunction in demyelinating diseases". Frontiers in Neurology (2023): https://www.frontiersin.org/research-topics/49012/mechanisms-of-myelin-misregulation-and-neuronal-dysfunction-in-demyelinating-diseases.
    Published • Editor
  8. Barbosa, Daniel José; Silva, Renata. "Molecular and cellular advances on drug discovery, pharmacology and toxicology". Medicina (2022): https://www.mdpi.com/journal/medicina/special_issues/drug_discovery_pharmacology_and_toxicology.
    Published • Editor
Preprint
  1. Cátia Carvalho; Barbosa, Daniel José; Ricardo Celestino; Esther Zanin; Ana Xavier Carvalho; Reto Gassmann. "Dynein directs prophase centrosome migration to control the stem cell division axis in the developing C. elegans epidermis". 2023. https://doi.org/10.1101/2023.09.25.559295.
    10.1101/2023.09.25.559295
  2. Sobral, A.F.; Chan, F.-Y.; Ferreira, V.; Osório, D.S.; Barbosa, D.J.; Cheerambathur, D.; Gassmann, R.; Xavier de Carvalho, A.. "Plastin and Heavy-Spectrin Cooperate to Stabilize the Actomyosin Cortex during Cytokinesis". 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110755737&partnerID=MN8TOARS.
    10.2139/ssrn.3779552
  3. Celestino, R.; Gama, J.B.; Castro-Rodrigues, A.F.; Barbosa, D.J.; D'Amico, E.A.; Musacchio, A.; Carvalho, A.X.; Morais-Cabral, J.H.; Gassmann, R.. "JIP3 regulates bi-directional organelle transport in neurons through its interaction with dynein and kinesin-1". 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85119831780&partnerID=MN8TOARS.
    10.1101/2021.10.11.463801
  4. Barbosa, Daniel José. "Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes". 2020. http://dx.doi.org/10.1101/2020.10.19.345041.
    10.1101/2020.10.19.345041
  5. Barbosa, D.J.; Duro, J.; Cheerambathur, D.K.; Prevo, B.; Carvalho, A.X.; Gassmann, R.. "Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport". 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095637707&partnerID=MN8TOARS.
    10.1101/130104
Thesis / Dissertation
  1. José Barbosa, Daniel. "Ecstasy´s Neurotoxicity: In Vitro Findings from Mitochondria to the Cell". PhD, Universidade do Porto Faculdade de Farmácia, 2013. https://hdl.handle.net/10216/71861.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/03 The effect of synthetic cannabinoid ADB-FUBINACA on primary neuronal cultures ß-galactosidase activity: preliminary findings III 1H-TOXRUN INTERNATIONAL CONGRESS
1H-TOXRUN RESEARCH UNIT - IUCS - CESPU (Porto, Portugal)
2023/02/24 Dynein-1 ensures proper cell fate commitment by orienting the mitotic spindle in the C. elegans hypodermis 9th MCBiology Symposium
Institute for Research and Innovation in Health (i3S) (Porto, Portugal)
2019/02/07 In vitro modulation of P-glycoprotein by xanthonic derivates: implications on Alzheimer's disease XLIX Annual Meeting of the Portuguese Pharmacological Society, XXXVII Meeting of Clinical Pharmacology and XVIII Meeting of Toxicology
Universidade do Porto Faculdade de Farmácia (Porto, Portugal)
2017/11/15 Role of dynactin's microtubule-binding activity during cell division
Universidade do Porto Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2017 Neuronal modulation of mitochondrial dynamics by 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") "Neurobiology of Addiction” module of the GABBA doctoral program 2017
Universidade do Porto Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2016 Neuronal modulation of mitochondrial dynamics by 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") "Neurobiology of Addiction” module of the GABBA doctoral program 2016
Universidade do Porto Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2015 Neuronal modulation of mitochondrial dynamics by 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") "Neurobiology of Addiction" module of the GABBA doctoral program 2015
Universidade do Porto Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2014/07 Aged rats are more prone to "ecstasy" neurotoxicity than adolescent rats L Congress of the European Societies of Toxicology
European Societies of Toxicology (Edinburgh, United Kingdom)
2014/02 New thioxanthones and dihydroxylated xanthones as P-glycoprotein inducers/activators XLIV Annual Meeting of the Portuguese Pharmacological Society, XXXII Meeting of Clinical Pharmacology and XIII Meeting of Toxicology
Universidade de Coimbra (Coimbra, Portugal)
2014 Neuronal modulation of mitochondrial dynamics by 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") "Neurobiology of Addiction" module of the GABBA doctoral program 2014
Universidade do Porto Instituto de Biologia Molecular e Celular (Porto, Portugal)
2014 Oxidative stress parameters in the brain and peripheral organs following exposure of adolescent rats to an MDMA neurotoxic regimen VII Meeting of Young Research
Universidade do Porto (Porto, Portugal)
2014 Oxidative stress parameters in the brain and peripheral organs following exposure of adolescent rats to an MDMA neurotoxic regimen XLIV Annual Meeting of the Portuguese Pharmacological Society, XXXII Meeting of Clinical Pharmacology and XIII Meeting of Toxicology
Universidade de Coimbra Faculdade de Farmácia (Coimbra, Portugal)
2014 The mixture of "ecstasy" and its metabolites, at in vivo relevant concentrations, impairs mitochondrial neuronal trafficking in a Mitofusin2/Drp1-dependent manner XLIV Annual Meeting of the Portuguese Pharmacological Society, XXXII Meeting of Clinical Pharmacology and XIII Meeting of Toxicology
Coimbra University (Coimbra, Portugal)
2013/09/01 "Ecstasy" impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß 49th Congress of the European Societies of Toxicology (EUROTOX)
European Societies of Toxicology (Interlaken, Switzerland)
2013/02/06 "Ecstasy" impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß XLIII Annual Meeting of the Portuguese Pharmacological Society, XXXI Meeting of Clinical Pharmacology and XII Meeting of Toxicology
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)
2013 Neuronal modulation of mitochondrial dynamics by 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") "Neurobiology of Addiction" module of the GABBA doctoral program 2013
Universidade do Porto Instituto de Biologia Molecular e Celular (Porto, Portugal)
2012 The mixture of “Ecstasy” and its metabolites is toxic to human SH-SY5Y differentiated cells, at physiologically relevant concentrations XLII Annual Meeting of the Portuguese Pharmacological Society, XXX Meeting of Clinical Pharmacology and XI Meeting of Toxicology
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2011/02/02 Oxidative damage induced by Ecstasy and its metabolites in mouse brain synaptosomes XLI Annual Meeting of the Portuguese Pharmacological Society, XXIX Meeting of Clinical Pharmacology and X Meeting of Toxicology
Universidade de Coimbra Faculdade de Medicina (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2025/09/01 - Current Ketamine and neuroplasticity: potential in neurodegenerative diseases
Supervisor of Theo Jean Guy Michel
 Ciências Farmacêuticas (Master)
Instituto Universitário de Ciências da Saúde, Portugal
2025/07/12 - Current In vitro and in vivo assessment of the combined neurotoxicity of Paraquat and 2,4-Dichlorophenoxyacetic acid: a mechanistic approach.
Co-supervisor of Rira Ferreira Azevedo
 Toxicologia e Contaminação Ambientais (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2025/02/01 - Current Enantiomer-specific toxicity profiling of ketamine in the C. elegans model
Supervisor of Maria João Duarte Hora
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/12/01 - Current The influence of ketamine on C. elegans behaviour
Supervisor of Diogo Alexandre Marques Ferreira
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/10/01 - Current Toxicology of ketamine in the C. elegans animal model
Supervisor of Otília Maria Gonçalves Lopes
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/09/01 - Current Impact of synthetic cathinones on development, motor function, reproduction, lifespan, and neurotoxicity in C. elegans
Co-supervisor of Mariana Almeida Lopes
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/03/01 - Current Culturomic and biochemical analysis of bacterial indicators for Postmortem Interval calculation
Co-supervisor of Maria João Soares Teixeira
 Ciências Forenses (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2023/12/01 - Current Biological characterization of synthetic analogous of sea-derived natural compounds as novel drug candidates for Alzheimer's Disease
Co-supervisor of Inês Silva Ferreira da Costa
 Ciências Farmacêuticas (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2023/12/01 - Current Exploring the unknown of lisdexamfetamine dimesylate (LDX): pharmacokinetics, pharmacodynamics and clinical aspects
Co-supervisor of Mariana Sofia Silva Carvalho
 Toxicologia (PhD)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2025/03/11 - 2025/06/16 Effects of the herbicide Roundup on the development of the animal model.
Supervisor of Lara Alexandra Monteiro Moreira
Biologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2024/10/01 - 2025/06/16 Toxicological interactions of synthetic cathinones and ethanol in the C. elegans animal model
Supervisor of Tatiana Sousa Moyisyeyenko
 Ciências Forenses (Degree)
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2024/10/01 - 2025/06/09 Herbicide risk assessment in C. elegans and toxicological implications for humans
Supervisor of Joana Beatriz Machado Sampaio Pinto
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2023/03/15 - 2024/12/17 Effects of the synthetic cathinones methylone and pentedrone on the development, reproductive function, and longevity of the C. elegans animal model
Supervisor of Cristina Alexandra da Silva Mendes
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2023/10/01 - 2024/07/17 Effects the synthetic cathinone 4-MEC on C. elegans development and behavior
Supervisor of Daniel Alexandra Coelho Maia
 Ciências Forenses (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2020/10/19 - 2024/04/09 Functional characterization of the microtubule motor dynein in the C. elegans epidermis
Co-supervisor of Cátia Filipa Vieira de Carvalho
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02/01 - 2023/12 Bacterial mapping for postmortem interval calculation
Co-supervisor of Ana Cláudia Coelho Ferreira
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2022/10/01 - 2023/09/14 Profiling of neuronal cytoskeleton and mitochondrial proteins for estimation of postmortem interval
Supervisor of Jacinta Eugénia Moreira de Matos
 Ciências Forenses (Degree)
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2016/09 - 2018/11/19 Screening of newly synthetized xanthonic derivatives as potential inducers/activators of P-gp: an innovative strategy to fight Alzheimer's disease
Co-supervisor of Eva Alexandra Gil Martins
 Master Degree in Analytical Clinical and Forensic Toxicology (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/01/01 - 2013/07/20 Preparation of synaptosomes and their use as a model to study the Na+/K+ ATPase
Supervisor
 Mestrado Integrado em Bioengenharia (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/12/04 - 2025/12/05 VII Congress of the Portuguese Association of Forensic Sciences – Reshaping Forensic Practice in Portugal: From Forensic Sciences to Forensic Science (2025/12/04 - 2025/12/05)
Congress (Member of the Organising Committee)
 Associação Portuguesa de Ciências Forenses, Portugal
2025/05/08 - 2025/05/09 IV 1H-TOXRUN INternational Congress 2025 (2025/05/08 - 2025/05/09)
Congress (Member of the Scientific Committee)
 Instituto Universitário de Ciências da Saúde, Portugal
2024/05/02 - 2024/05/03 III 1H-TOXRUN International Congress 2024 (2024/05/02 - 2024/05/03)
Congress (Member of the Scientific Committee)
 Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2023/04/27 - 2023/04/28 II TOXRUN International Congress 2023 (2023/04/27 - 2023/04/28)
Congress (Member of the Scientific Committee)
 Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/05/08 - 2025/05/09 IV 1H-TOXRUN International Congress 2025
Congress
 IV 1H-TOXRUN INternational Congress 2025
Instituto Universitário de Ciências da Saúde, Portugal
2024/10/16 - 2024/10/16 PhD Day IUCS 2024 - Empowering Change: Strategies to Achieve the Goals of the 2030 Agenda
Conference
 PhD Day IUCS 2024 - Empowering Change: Strategies to Achieve the Goals of the 2030 Agenda
Instituto Universitário de Ciências da Saúde, Portugal
2024/05/02 - 2024/05/03 III 1H-TOXRUN International Congress 2024
Congress
 III 1H-TOXRUN International Congress 2024
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2023/04/27 - 2023/04/28 II TOXRUN International Congress 2023
Congress
 II TOXRUN International Congress 2023
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2022/04/07 - 2022/04/08 I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences
Congress
 I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal

Associação Portuguesa de Ciências Forenses, Portugal
2019/05/07 - 2019/05/10 EMBO Workshop - Cell Biology of the Neuron: Polarity, Plasticity and Regeneration
Congress
 Cell Biology of the Neuron: Polarity, Plasticity and Regeneration
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
2019/04/15 - 2019/04/17 EMBO Laboratory Leadership Course EMBO Laboratory Leadership Course
European Molecular Biology Laboratory, Germany
2019/02/06 - 2019/02/08 XLIX Annual Meeting of the Portuguese Pharmacological Society, XXXVII Meeting of Clinical Pharmacology and XVIII Meeting of Toxicology
Congress
 XLIX Annual Meeting of the Portuguese Pharmacological Society, XXXVII Meeting of Clinical Pharmacology and XVIII Meeting of Toxicology
Universidade do Porto Faculdade de Farmácia, Portugal
2018/11/29 - 2018/11/30 VII Annual Meeting of the Institute for Research and Innovation in Health
Conference
 VII Annual Meeting of the Institute for Research and Innovation in Health
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/11/09 - 2017/11/10 VI Annual Meeting of the Institute for Research and Innovation in Health
Conference
 VI Annual Meeting of the Institute for Research and Innovation in Health
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/09/19 - 2017/09/21 Course - Introduction to digital image analysis with ImageJ/Fiji
Other
 Introduction to digital image analysis with ImageJ/Fiji
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/11/03 - 2016/11/04 V Annual Meeting of the Institute for Research and Innovation in Health
Conference
 V Annual Meeting of the Institute for Research and Innovation in Health
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/05/28 - 2016/06/01 EMBO/EMBL Symposium: Microtubules: From Atoms to Complex Systems
Symposium
 EMBO/EMBL Symposium: Microtubules: From Atoms to Complex Systems
EMBO/EMBL , Germany
2014/04/14 - 2014/04/16 Course - Working with ImageJ and ICY: hands on image analysis for microscopy
Other
 Working with ImageJ and ICY: hands on image analysis for microscopy
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2014/02/05 - 2014/02/07 XLIV Annual Meeting of the Portuguese Pharmacological Society, XXXII Meeting of Clinical Pharmacology and XIII Meeting of Toxicology
Congress
 XLIV Annual Meeting of the Portuguese Pharmacological Society, XXXII Meeting of Clinical Pharmacology and XIII Meeting of Toxicology
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/07/13 - 2013/07/13 Symposium - Science Heartbeat - GABBA 16th Annual Symposium
Conference
 Science Heartbeat - GABBA 16th Annual Symposium
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/05/25 - 2013/05/25 Workshop - A Medicação na Esclerose Múltipla
Conference
 A medicação na Esclerose Múltipla
TEM - Associação Todos com a Esclerose Múltipla, Portugal
2013/02/06 - 2013/02/08 XLIII Annual Meeting of the Portuguese Pharmacological Society, XXXI Meeting of Clinical Pharmacology and XII Meeting of Toxicology
Congress
 XLIII Annual Meeting of the Portuguese Pharmacological Society, XXXI Meeting of Clinical Pharmacology and XII Meeting of Toxicology
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/06/17 - 2012/06/20 XLVIII Congress of the European Societies of Toxicology (EUROTOX)
Congress
 XLVIII Congress of the European Societies of Toxicology (EUROTOX)
EUROTOX, Belgium
2012/05 - 2012/05 ImageJ: Introductory Course
Other
 ImageJ: Introductory Course
Institut de Recerca Biomèdica, Spain
2012/02/01 - 2012/02/03 XLII Annual Meeting of the Portuguese Pharmacological Society, XXX Meeting of Clinical Pharmacology and XI Meeting of Toxicology
Congress
 XLII Annual Meeting of the Portuguese Pharmacological Society, XXX Meeting of Clinical Pharmacology and XI Meeting of Toxicology
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/08/28 - 2011/08/31 XLVII Congress of the European Societies of Toxicology (EUROTOX)
Congress
 XLVII Congress of the European Societies of Toxicology (EUROTOX)
EUROTOX, Belgium
2011/05/02 - 2011/05/02 Introduction to experimental design in biomedical research
Conference
 Introduction to experimental design in biomedical research
Universidade do Porto Faculdade de Farmácia, Portugal
2011/02/02 - 2011/02/04 XLI Annual Meeting of the Portuguese Pharmacological Society, XXIX Meeting of Clinical Pharmacology and X Meeting of Toxicology
Congress
 XLI Annual Meeting of the Portuguese Pharmacological Society, XXIX Meeting of Clinical Pharmacology and X Meeting of Toxicology
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/12/15 - 2010/12/17 XVII National Meeting of Biochemistry
Congress
 XVII National Meeting of Biochemistry
Sociedade Portuguesa de Bioquímica, Portugal
2010/07/19 - 2010/07/23 XII International Congress of Toxicology
Congress
 XII International Congress of Toxicology
International Union of Toxicology, United States
2010/05/03 - 2010/05/03 Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration
Seminar
 Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration
Universidade do Porto Faculdade de Farmácia, Portugal
2010/04/19 - 2010/04/23 Cell Cycle and Death
Other
 Ciclo e morte celular
Universidade do Porto Faculdade de Farmácia, Portugal
2010/03/16 - 2010/03/22 Clones, genes and mobile genetic elements: pieces of the antibiotic resistance puzzle
Other
 Clones, genes e elementos genéticos móveis: peças do puzzle da resistência a antibióticos
Universidade do Porto Faculdade de Farmácia, Portugal
2010/01/27 - 2010/01/27 Automating the determination of antioxidant capacity through Flow Injection Analysis
Conference
 Automatização da determinação da capacidade antioxidante através da Análise por Injecção de Fluxo
Universidade do Porto Faculdade de Farmácia, Portugal
2010/01/27 - 2010/01/27 Quimiluminescence: Analytical aplications
Conference
 Quimiluminescência: Aplicações Analíticas
Universidade do Porto Faculdade de Farmácia, Portugal
2008 - 2008 HappyDerm
Workshop
 HappyDerm
Universidade do Porto Faculdade de Farmácia, Portugal
2001 - 2001 Informatics Course
Other
 Informatics Course

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2025/06/12 Impact of Synthetic Cannabinoids on mitochondrial function and dynamics during in vitro neuronal development
(Thesis) Main arguer
 Rui Filipe Cerqueira Malheiro (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2025/04/24 Role of the serotonin receptor 5-HT3/LGC-50 in Spinocerebellar Ataxia type 3 pathogenesis: a C. elegans-based study
(Thesis) Main arguer
 Lídia Daniela Carvalho Nunes (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2024/12/09 Unravelling the neurotoxicity of synthetic cathinones in a neuritogenesis model
(Thesis) Main arguer
 Catarina Teixeira da Fonseca (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2024/11/14 Study on individuals using/dependent on cocaine/crack evaluated in the Psychiatry Department of the Forensic Medicine Institute of Paraná
(Thesis) Main arguer
 Rodrigo Pirard Basso (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2022/12/16 Alzheimer's disease: unraveling the biological activity of novel synthetic compounds targeting tau hyperphosphorylation and the amyloid-beta pathway
(Thesis) Main arguer
 Ana Rita Pinto Monteiro (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/12/16 In vitro study of Innovative Antiparkinsonian agents: evaluation of their toxicological profile and neuroprotective potential
(Thesis) Main arguer
 Inês Silva Ferreira da Costa (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/11/28 In vitro neurodevelopmental deregulation induced by the synthetic cannabinoids AMB-FUBINACA, ADBFUBINACA, AB-CHMINACA, HU-308 and THJ-2201
(Thesis) Main arguer
 Carolina Lobato de Freitas (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/12/11 Marine-derived compounds as potential neuroprotective agents
(Thesis) Main arguer
 Sandra Filipa Carvalho Barreiro (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/11/27 In vitro assessment of the effects of heroin on telomere length
(Thesis) Main arguer
 Lina Solange Pereira Matos (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/11/21 Newly synthetized xanthones as potential P-glycoprotein and BCRP modulators at the intestinal barrier: in vitro and ex vivo studies
(Thesis) Main arguer
 Vera Lúcia Santos Silva (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2024/11 - Current Portuguese Association of Forensic Sciences Associate member

Committee member

Activity description
Role 		Institution / Organization
2025/10/16 - 2025/10/16 PhD Day IUCS 2025 - Scientific Career 360: Challenges, Strategies, and Opportunities
Member
 Instituto Universitário de Ciências da Saúde, Portugal
2024/10/16 - 2024/10/16 PhD Day IUCS 2024 - Empowering Change: Strategies to Achieve the Goals of the 2030 Agenda
Member
 Instituto Universitário de Ciências da Saúde, Portugal

Conference scientific committee

Conference name Conference host
2025/05/08 - 2025/05/09 IV 1H-TOXRUN International Congress 2025 Porto
2024/10/16 - 2024/10/16 PhD Day IUCS 2024 - Empowering Change: Strategies to Achieve the Goals of the 2030 Agenda IUCS - CESPU
2024/05/02 - 2024/05/03 III 1H-TOXRUN International Congress 2024 Porto
2023/04/27 - 2023/04/28 II TOXRUN International Congress 2023 Porto

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2025/06 - 2025/06 Reviewer of a research project funding application submitted to CESPU under the GI2-CESPU-2025 call
Evaluator
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal Cooperativa de Ensino Superior Politécnico e Universitário
2024/07 - 2024/07 Reviewer of a research project funding application for the Dr. Mário Fonseca Prize by Câmara Municipal de Lousada
Evaluator
 Câmara Municipal de Lousada, Portugal Câmara Municipal de Lousada
2023/12 - 2024/01 Reviewer of a research project funding application submitted to CESPU under the GI2-CESPU-2023 call
Evaluator
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal Cooperativa de Ensino Superior Politécnico e Universitário
2022/06 - 2022/06 Reviewer of a research project funding application submitted to CESPU under the GI2-CESPU-2022 call
Evaluator
 Cooperativa de Ensino Superior Politécnico e Universitário, Portugal Cooperativa de Ensino Superior Politécnico e Universitário

Journal scientific committee

Journal title (ISSN) Publisher
2025/07 - Current Critical Reviews in Food Science and Nutrition (1549-7852) Taylor & Francis Online
2025/07 - Current Life (2075-1729) MDPI
2025/07 - Current Journal of Nutritional Biochemistry (0955-2863) Elsevier
2025/07 - Current Environmental Toxicology (1520-4081) Wiley Online Library
2025/07 - Current Frontiers in Toxicology (2673-3080) Frontiers
2025/06 - Current Food Frontiers (2643-8429) Wiley Online Library
2025/05 - Current Journal of Medicinal Chemistry (0022-2623) ACS Publications
2025/04 - Current Redox Report (1351-0002) Taylor & Francis Online
2025/04 - Current Neuropharmacology (1873-7064) Elsevier
2025/03 - Current ACS Pharmacology & Translational Science (2575-9108) ACS Publications
2025/03 - Current Journal of Developmental Biology (2221-3759) MDPI
2025/03 - Current Cancers (2072-6694) MDPI
2025/03 - Current Neurology International (2035-8377) MDPI
2025/01 - Current Aging and Disease (2152-5250) JKL International Ltd., on behalf of the International Society on Aging and Disease (ISOAD)
2025/01 - Current Current Forensic Science (2666-4844) Bentham Science
2025/01 - Current Particle and Fibre Toxicology (1743-8977) BioMed Central Ltd
2024/12 - Current Scientific Letters (2795-5117) IUCS-CESPU
2024/11 - Current Scientific Reports (2045-2322) Nature Portfolio
2024/11 - Current FEBS Journal (1742-4658) Wiley Online Library
2024/09 - Current Frontiers in Immunology (1664-3224) Frontiers
2024/09 - Current Nutrients (2072-6643) MDPI
2024/06 - Current Basic & Clinical Pharmacology & Toxicology (1742-7843) Wiley Online Library
2024/06 - Current Journal of Alzheimer's Disease (1387-2877) IOS Press
2024/05 - Current Frontiers in Neuroscience (1662-453X) Frontiers
2024/03 - Current Antioxidants & Redox Signaling (1523-0864) Mary Ann Liebert, Inc
2024/02 - Current Genes (2073-4425) MDPI
2024/02 - Current Journal of Personalized Medicine (2075-4426) MDPI
2024/02 - Current Artificial Intelligence in Health (3029-2387) AccScience Publishing
2024/02 - Current Alzheimer's Research & Therapy (1758-9193) BioMed Central Ltd
2024/01 - Current Brain Sciences (2076-3425) MDPI
2023/11 - Current MedComm (2688-2663) Wiley Online Library
2023/10 - Current Molecular Neurobiology (0893-7648) Springer Nature
2023/09 - Current Metabolites (2218-1989) MDPI
2023/09 - Current Proceedings of the National Academy of Sciences of the United States of America (1091-6490) National Academy of Sciences
2023/08 - Current Cancer Medicine ( 2045-7634) Wiley Online Library
2023/08 - Current Forensic Sciences (2673-6756) MDPI
2023/07 - Current Medicine (1536-5964) Lippincott Williams & Wilkins
2023/07 - Current Biotechnology and Genetic Engineering Reviews (0264-8725) Taylor & Francis Online
2023/06 - Current Antioxidants (2076-3921) MDPI
2023/03 - Current Pharmaceuticals (1424-8247) MDPI
2023/03 - Current Nanomaterials (2079-4991) MDPI
2023/02 - Current Endocrines (2673-396X) MDPI
2023/01 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2023/01 - Current Current Medical Chemistry (0929-8673) Bentham Science
2023/01 - Current Anti-Cancer Agents in Medicinal Chemistry (1871-5206) Bentham Science
2022/12 - Current Biomedicines (2227-9059) MDPI
2022/12 - Current Life Sciences (0024-3205) Elsevier
2022/12 - Current Medicina (1648-9144) MDPI
2022/11 - Current Plants (2223-7747) MDPI
2022/11 - Current Microorganisms (2076-2607) MDPI
2022/10 - Current Neurotoxicology (0161-813X) Elsevier
2022/09 - Current Translational Psychiatry (2158-3188) Nature Publishing Group
2022/08 - Current Toxics (2305-6304) MDPI
2022/07 - Current Psychoactives (2813-1851) MDPI
2022/06 - Current Applied Sciences (2076-3417) MDPI
2022/05 - Current International Journal of Environmental Research and Public Health (1660-4601) MDPI
2022/03 - Current Biology (2079-7737) MDPI
2022/01 - Current Cells (2073-4409) MDPI
2021/09 - Current Journal of Clinical Medicine (2077-0383) MDPI
2021/07 - Current Brain Research Bulletin (1873-2747) Elsevier
2021/06 - Current Reproductive Toxicology (0890-6238) Elsevier
2019/06 - Current Aging (1945-4589) Impact Journals, LLC
2019/06 - Current Birth Defects Research (2472-1727) Wiley Online Library
2019/05 - Current Case Reports in Critical Care (2090-6420) Wiley Online Library
2017/07 - Current Neurotoxicity Research (1476-3524) Springer Nature
2016/01 - Current Toxicology Research (2045-452X) Oxford University Press
2015/11 - Current Drugs in R&D (1179-6901) Springer Nature

Mentoring / Tutoring

Topic Student name
2018/10 - 2019/08 Grace Walsh
2018/05/01 - 2018/11/30 Vanessa Maria Alves Teixeira
2015/09/01 - 2018/07/31 Joana Maria Duro Fernandes

Other jury / evaluation

Activity description Institution / Organization
2025/07/24 - Current Synthetic cathinones and neurodevelopment: A comprehensive review of their impact on neuronal differentiation Universidade do Porto Faculdade de Farmácia, Portugal
2025/05/15 - Current The Greater Weever (Trachinus draco): Clinical and forensic aspects of dracotoxin. Universidade do Porto Faculdade de Medicina, Portugal
2024/06/04 - Current Metabolism of mCPP, trazodone, nefazodone and etoperidone: Clinical and forensic aspects Universidade do Porto Faculdade de Medicina, Portugal
2024/03/08 - 2024/03/08 Using solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as a smart approach to improve the treatment of acute migraine via the nose-brain route Universidade do Porto Faculdade de Farmácia, Portugal
2023/09/04 - 2023/09/04 Pharmacokinetics and pharmacodynamics of gabapentin: Clinical and forensic features of abuse Universidade do Porto Faculdade de Medicina, Portugal
2022/09/07 - 2022/09/07 Pharmacokinetics and pharmacodynamics of buprenorphine: Relevant clinical and forensic aspects Universidade do Porto Faculdade de Medicina, Portugal
2021/11/08 - 2021/11/08 Co-culture models: key players in in vitro neuroscience studies Universidade do Porto Faculdade de Farmácia, Portugal
2021/08/02 - 2021/08/02 Investigating the regulation of Dynein-2 during cilia-mediated signaling Universidade do Porto Faculdade de Medicina, Portugal
2021/07/29 - 2021/07/29 Targeting ferroptosis as a new approach in the treatment of neurodegenerative diseases Universidade do Porto Faculdade de Farmácia, Portugal
2021/07/22 - 2021/07/22 The toxicology behind 2C and NBOMe psychedelic phenethylamines Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2018 How are Sac Proteins anchored to the nuclear pore? Is TPR location at the nuclear pore required for SAC signaling? Universidade do Porto Faculdade de Ciências, Portugal
2015/07/27 - 2015/07/27 The neuro- and cardio- toxicity of the clinically useful drugs in ADHD: amphetamine and methylphenidate Universidade do Porto Faculdade de Farmácia, Portugal
Distinctions

Award

2024 Annual scientific productivity award
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2023 Best Poster Award
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2023 Annual scientific productivity award
Instituto Universitário de Ciências da Saúde, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2014 Honorable Mention awarded by the American Society of Toxicology (SOT) to a research paper.
The American Society of Toxicology (SOT), United States
2004 Diploma of merit for excellent academic performance
Externato Infante D. Henrique/Alfacoop, Portugal
2003 Diploma of merit for excellent academic performance
Externato Infante D. Henrique/Alfacoop, Portugal
2002 Diploma of merit for excellent academic performance
Externato Infante D. Henrique/Alfacoop, Portugal
2001 Diploma of merit for excellent academic performance
Externato Infante D. Henrique/Alfacoop, Portugal

Other distinction

2014 FCT Postdoctoral fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2009 FCT Doctoral Fellowship
Fundação para a Ciência e a Tecnologia, Portugal