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Cancer researcher with 16+ years of experience in tumor microenvironment biology, immunotherapy, gene editing, and targeted therapies, with a strong focus on rare pediatric solid tumors, particularly sarcomas. My work is driven by a strong translational vision, aiming to convert molecular and cellular discoveries into actionable therapeutic strategies that improve clinical outcomes. I hold a Degree and MSc in Pharmacy from the University of Coimbra. Early in my career, I was awarded a competitive fellowship to join Dr. Enrique de Álava’s group in Salamanca, followed by a PhD fellowship from the Fundação para a Ciência e Tecnologia . I completed my PhD in Molecular Biology of Cancer at the Cancer Research Center, Universidad de Salamanca, focusing on Ewing sarcoma, and subsequently continued as a postdoctoral researcher in Dr. de Álava’s team at the Institute of Biomedicine of Seville (IBiS). During this period, I also earned an MSc in Clinical Trials from the University of Seville, strengthening my ability to bridge experimental research and clinical application. My postdoctoral trajectory includes international experience at the Institute of Cancer Research (London) under Dr. Janet Shipley, where I developed advanced 3D tumor models and optimized innovative invasion assays. I later joined the Tumor Microenvironment and Targeted Therapies Group at CNC – Universidade de Coimbra, initially as a visiting researcher and subsequently as an auxiliary researcher. In parallel with my research activities, I am a lecturer in MSc and PhD programs, where I teach and coordinate modules in tumor microenvironment, translational oncology, and experimental design, and supervise graduate research projects. In 2024, I was awarded a Marie Sklodowska-Curie Actions Postdoctoral Fellowship (ERA Fellowship) to lead DSRCT-CAR-T, a project dedicated to advancing CAR-T cell strategies for desmoplastic small round cell tumor (DSRCT) and other immunologically cold solid tumors. My recent work includes the generation of genetically engineered disease models, the study of tumor–stroma interactions, and the design of gene-editing-driven therapeutic approaches. In parallel with my academic career, I am a co-founder of a_b_c_Scientists, a science outreach and education initiative focused on inspiring young students and promoting scientific literacy through hands-on activities, school-based programs, and engagement with the broader community. I have secured independent competitive funding, mentored MSc and PhD students, and fostered multidisciplinary collaborations with clinicians, with the overarching goal of translating innovative biological discoveries into effective therapies for patients with rare pediatric malignancies.
Identification

Personal identification

Full name
ANA TERESA MONTEIRO AMARAL

Citation names

  • Amaral, A. T.

Author identifiers

Ciência ID
FD1F-F6B7-E53E
ORCID iD
0000-0001-7887-4814
Google Scholar ID
https://scholar.google.com/citations?user=mJF59dYAAAAJ&hl=pt-PT
Scopus Author Id
https://www.scopus.com/authid/detail.uri?authorId=26634671800

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Italian Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1) Beginner (A1)
French Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2014 - 2015
Concluded
Clinical Trials (Master)
Universidad de Sevilla, Spain
8.3/10
2009 - 2014/09/18
Concluded
Molecular and Clinical Biology of Cancer (Doctor of Philosophy)
Major in Molecular and Clinical Biology of Cancer
Universidad de Salamanca, Spain

Instituto de Biología Molecular y Celular del Cáncer, Spain
"The pathogenesis of Ewing Sarcoma: Implications of Mesenchymal Stem Cells and New Therapeutic Strategies" (THESIS/DISSERTATION)
Sobresaliente, Cum Laude
2008/09 - 2010/12
Concluded
Diploma of Advanced Studies: Molecular and Clinical Biology of Cancer (DEA)
Major in Molecular oncology
Universidad de Salamanca, Spain
"Estudio de la Célula Stem Mesenquimal en Sarcoma de Ewing" (THESIS/DISSERTATION)
2002 - 2008
Concluded
Pharmaceutical Sciences-Faculty of Pharmacy (Mestrado integrado)
Major in Pharmaceutical Sciences
Universidade de Coimbra Faculdade de Farmácia, Portugal
15
Affiliation

Science

Category
Host institution
Employer
2024/09/01 - 2026/08/31 Invited Principal Investigator (Research) Universidade de Coimbra, Portugal
European Research Executive Agency, Belgium
(...)
2023/05/04 - 2024/08/31 Auxiliary Researcher (Research) Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2023/03/01 - 2023/04 Science and Technology Management Nordic Innovators P/S, Denmark
2014/12/31 - 2022/12/31 Auxiliary Researcher (Research) Instituto de Biomedicina de Sevilla, Spain
Instituto de Biomedicina de Sevilla, Spain
(...)
2022/09/01 - 2022/12/01 Visiting Researcher (Research) Universidade de Coimbra, Portugal
Tumor Microenvironment and Targeted Therapies group-CNC-UC, Portugal
2018/09 - 2018/12 Visiting Researcher (Research) The Institute of Cancer Research, United Kingdom
The Institute of Cancer Research, United Kingdom
2009 - 2014 Researcher (Research) Instituto de Biología Molecular y Celular del Cáncer, Spain
Instituto de Biología Molecular y Celular del Cáncer, Spain
2008 - 2009 Research Trainee (Research) Instituto de Biología Molecular y Celular del Cáncer, Spain
Instituto de Biología Molecular y Celular del Cáncer, Spain
Projects

Grant

Designation Funders
2022 - Current New insights into the Desmoplastic small round cell tumour: comprehensive molecular characterization to identify therapeutic targets and new biomarkers
...
Supervisor
Instituto de Biomedicina de Sevilla, Spain

Universidad de Sevilla, Spain

Universidade de Coimbra, Portugal
Ongoing
2025 - 2027 DReAM: Dendritic Cell Reprogramming in Asbestos-related Mesothelioma: Unveiling New Therapeutic Possibilities
2023.11762.PEX
Post-doc
Universidade de Coimbra, Portugal

Lunds Universitet, Sweden
Ongoing
2025 - 2027 CRTC3 as a theragnostic biomarker in desmoplastic small round cell tumor (DSRCT): from molecular characterization to clinical application
Post-doc Fellow
Instituto de Biomedicina de Sevilla, Spain

Universidade de Coimbra, Portugal
Ongoing
2025/05/01 - 2026/11/01 D(C)ART: Desmoplastic Small Round Cell Tumor: Crossing the matrix & innovating in the treatment of pediatric solid tumors with CAR-T cells
lllll
Principal investigator
Fundação Rui Osório de Castro, Portugal
Ongoing
2025/02/08 - 2026/10/07 Tracing lipid nanoparticle-mediated mRNA delivery in Live Tumor Cells by Raman Confocal Imaging
2023.11762.PEX
Post-doc
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2025 Genomic instability in undifferentiated small round cell sarcomas: an opportunity for precision medicine
Post-doc Fellow
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain
Ongoing
2022/01/01 - 2023 Tailored adoptive cellular immunotherapy for Ewing Sarcoma
Post-doc
Instituto de Biomedicina de Sevilla, Spain

Fundación Josep Carreras contra la Leucemia, Spain
Obra Social La Caixa
Ongoing
2022 - 2023 Development of an innovative adoptive CAR-T cell immunotherapy for Ewing sarcoma
Post-doc Fellow
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain

Fundación Josep Carreras contra la Leucemia, Spain
Concluded
2021 - 2023 Integrative molecular-testing platform for precision diagnostics and personalized care of sarcoma patients
Post-doc
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain
Fundacion Maripaz Jimenez Casado
Concluded
2021 - 2023 IV Mari Paz Jiménez Casado Three-Year Fellowship for Research in Sarcoma
FMPGC20
Post-doc Fellow
Hospital Universitario Virgen del Rocío, Spain

Instituto de Biomedicina de Sevilla, Spain
Fundacion Maripaz Jimenez Casado
Concluded
2020 - 2023 Study of the prognostic and functional role of mesenchymal stem cell markers Endoglin and ALCAM in the disease progression of Clear cell sarcomas (CCS) and Desmoplastic small Round cell tumors (DSRCT)
P18-RT-735
Principal investigator
Instituto de Biomedicina de Sevilla, Spain
Junta de Andalucía
Concluded
2020 - 2023 New insights into the Desmoplastic small round cell tumour: comprehensive molecular characterization to identify therapeutic targets and new biomarkers
400300200313
Principal investigator
Instituto de Biomedicina de Sevilla, Spain
Grupo Espanol Investigacion Sarcomas
Concluded
2020 - 2023 Evaluación de STAT6 como biomarcador de diagnóstico de precisión y diana terapéutica en Tumor Fibroso Solitario
PI-0061-2020
Post-doc Fellow
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain
Consejería de Salud y Familias, Junta de Andalucía
Concluded
2019 - 2023 Translational assessment of predictive factors of response of Ewing sarcoma to genotoxic therapy
S1900239
Principal investigator
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain

University College London, United Kingdom

University of Michigan, United States
Sarcoma Foundation of America
2019 - 2022/12 CIBERONC-Centro de Investigacio Biomedica en RED: Low prevalence tumours program
Post-doc
Centro de Investigación Biomédica en Red de Cáncer, Spain
Ongoing
2021 - 2022 Intratumoral heterogeneity in t-sarcomas: A silver lining for precision therapeutics
PI20-0003
Post-doc
Instituto de Biomedicina de Sevilla, Spain
Instituto de Salud Carlos III
Ongoing
2020 - 2022 Evaluation of STAT6 as a precision diagnostic biomarker and therapeutic target in Solitary Fibrous Tumor
PI-0061-2020
Post-doc
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain
Junta de Andalucía
Concluded
2018 - 2021 Evaluation of the clinical potential of the vesicular crosstalk in response to drugs in the context of Ewing sarcoma. PI-0040-2017
PI-0040-2017
Principal investigator
Instituto de Biomedicina de Sevilla, Spain
Junta de Andalucía
Concluded
2018 - 2020 New therapeutic targets in Ewing sarcoma through the study of the metastatic process
PI1700464
Post-doc
Instituto de Biomedicina de Sevilla, Spain
Instituto de Salud Carlos III
Concluded
2018 - 2019 3D-ID Project: Personalized 3D cultures for treatment selection for cancer patients in precision medicine
Post-doc
Instituto de Biomedicina de Sevilla, Spain

STEMTEK THERAPEUTICS SL, Spain

FUNDACIÓN ONKOLOGIKOA FUNDAZIOA, Spain

Institut d'Investigació Biomèdica de Bellvitge, Spain
Cancelled
2013 - 2019 EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (ECC)
PhD Student Fellow
associacion Española Contra él Cancér (AECC)
Concluded
2017 - 2018 PROspective VAlidation of Biomarkers in Ewing Sarcoma for personalized translational medicine
Post-doc
Hospital Universitario Virgen del Rocío, Spain

IRCCS Istituto Ortopedico Rizzoli, Italy

St James's University Hospital, United Kingdom

Institut Curie, France

Klinikum rechts der Isar der Technischen Universität München, Germany
European Commission
Concluded
2017 - 2018 Study of the prognostic value of endoglin and its functional role in uveal melanoma,
Post-doc Fellow
associacion Española Contra él Cancér (AECC)
Concluded
2014 - 2017 New therapeutic targets in Ewing sarcoma: study of the microenvironment
PI14/01466
Post-doc
Instituto de Biomedicina de Sevilla, Spain
Instituto de Salud Carlos III
Concluded
2014 - 2017 Implications of the vesicular crosstalk in the Ewing Sarcoma microenvironment
PM2
Post-doc Fellow
Concluded
2014 - 2016 Endowing relevance to endoglin in Ewing sarcoma pathology: development of innovative personalized treatments
Post-doc
Instituto de Biomedicina de Sevilla, Spain

Oncomatryx, Spain
Concluded
2014 - 2016 Study of the Hippo Tumor Suppressor Pathway in Ewing Sarcoma. Translational Application for Patient Stratification and as a Novel Therapeutic Approach
PI-0344-2014
Post-doc Fellow
Instituto de Biomedicina de Sevilla, Spain

Hospital Universitario Virgen del Rocío, Spain
Concluded
2013/03/02 - 2016 RTICC RD12/0036/0017
RTICC RD12/0036/0017
PhD Student Fellow
Concluded
2014 - 2015 ALCAM relevance in the mechanistic regulation of cell clustering and migration in Ewing sarcoma
Post-doc
associacion Española Contra él Cancér (AECC)
Concluded
2013 - 2015 EUROSARC (Project ID 278742): European clinical trials in rare sarcomas through an integrated translational trial network
PhD Student Fellow
associacion Española Contra él Cancér (AECC)
Concluded
2012 - 2014 Search, validation, and clinical translation of therapeutic targets in Ewing sarcoma
PI1100018
Post-doc
Instituto de Biomedicina de Sevilla, Spain
associacion Española Contra él Cancér (AECC)
Concluded
2009 - 2011 Mechanisms of initiation of Ewing sarcoma: signaling and cellular propagation
PI081828
PhD Student Fellow
Instituto de Biología Molecular y Celular del Cáncer, Spain

Universidad de Salamanca, Spain
Concluded
2008 - 2010 EUROBONET (FP6-2004/018814): European network to promote research into uncommon cancers in adults and children, focusing on the pathology, biology, and genetics of bone tumors
PhD Student Fellow
associacion Española Contra él Cancér (AECC)
Concluded
2008/01/01 - 2009/12/31 Translocation-related tumors. A Translational study on predictors of response to Yondelis and its analogs
Pharma Mar
PhD Student Fellow
Concluded

Contract

Designation Funders
2025/09 - Current Dual-Targeting in Desmoplastic Small Round Cell Tumor Models: Overcoming Matrix Barriers While Abrogating the Fusion Gene
2025.01860.BD
Supervisor
Ongoing
2024/01/09 - Current ERA Fellowships (HORIZON-WIDERA-2022-TALENTS-04)
Post-doc
Universidade de Coimbra, Portugal
ERA Fellowships - European Research Executive Agency
2023/05/01 - 2024/08/31 CiNTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
C644865576-00000005
Post-doc Fellow
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
European Union
Ongoing
2017 - 2021 Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy
Supervisor
Institute of Genetics and Cancer, United Kingdom

Instituto de Biomedicina de Sevilla, Spain
Concluded
2014 - 2018 Stable Coordinated Groups B2013 (AECC): Clinical translation of novel therapeutic targets identified through integrative genomics and epigenomics in Ewing sarcoma.
Post-doc Fellow
Instituto de Biomedicina de Sevilla, Spain

Hospital Sant Joan de Déu, Spain

Institut d'Investigació Biomèdica de Bellvitge, Spain
associacion Española Contra él Cancér (AECC)
Concluded
Outputs

Publications

Book chapter
  1. Cardoso, Hugo; Panão Costa, João; Amaral, Ana; SOARES-GONÇALVES, JOÃO MANUEL; Voronovska, Anastasiya; Batista, Ana; Moreira, Joãp Nuno. "Advances in RNA-based Therapeutics in Oncology". In Springer Handbook of Medical Biotechnology. Springer Nature, 2025.
    Accepted
Conference abstract
  1. Amaral, A. T.. "Immune Profiling of Desmoplastic Small Round Cell Tumor: Barriers and Opportunities". Paper presented in 51st Annual Meeting of the Portuguese Society for Immunology, Coimbra, 2026.
    Submitted
  2. Amaral, A. T.. "EACR23-1377EWS::FLI1-DHX9 interaction alters R-loopmetabolism promoting Ewing sarcomasensitivity to genotoxic agents". Paper presented in EACR 2023 Congress (Innovative Cancer Science), Turin, 2023.
    Published
  3. Amaral, A. T.. "EACR23-0517Unravelling the molecular landscape ofDesmoplastic Small Round Cell Tumor". Paper presented in EACR 2023 Congress (Innovative Cancer Science), Turin, 2023.
    Published
  4. Amaral, A. T.. "OGM: Unraveling the genomic landscape of Solitary Fibrous Tumor". Paper presented in Bionano Genomics, Seville, 2023.
    Published
  5. Amaral, A. T.. "Optical Genome Mapping: Unravelling the genomic landscape of Solitary Fibrous Tumor Poster". Paper presented in EACR 2022 Congress - Innovative Cancer Science, seville, 2022.
    Published
  6. Amaral, A. T.. "Exploring the role of Endoglin in the aggressiveness of Ewing and Clear Cell Sarcoma". Paper presented in EACR 2022 Congress - Innovative Cancer Science, seville, 2022.
    Published
  7. Amaral, A. T.. "EWS/FLI1 interacts with DHX9 promoting R-loop accumulation and drug sensitivity in Ewing Sarcoma". Paper presented in EACR 2022 conference. European association for cancer research. 2022. Seville, Spain., Seville, 2022.
    Published
  8. Amaral, A. T.. "Abstract 6158: The relevance of endoglin and MMP14 to the metastatic potential of Ewing sarcoma cells". Paper presented in AACR Annual Meeting, 2020.
    Published
  9. Amaral, A. T.. "Unravelling endoglin as a potential therapeutic target for the treatment of uveal melanoma First author, poster presentatio". Paper presented in 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018, Amesterdam, 2018.
    Published
  10. Amaral, A. T.. "Preclinical efficacy of the endoglin-based antibody–drug conjugate OMTX703 for the treatment of Ewing sarcoma". Paper presented in CTOS 2017, Hawaii, 2017.
    Published
  11. Amaral, A. T.. "O-459 Unravelling endoglin as a potential therapeutic target for the treatment of uveal melanoma.". Paper presented in European Association for Cancer Research (EACR) 2025, Amesterdam, 2016.
    Published
  12. Amaral, A. T.. "Targeting Ewing Sarcoma cells and the tumor microenvironment with OMTX003 anti-endoglin monoclonal antibodies". Paper presented in CTOS 2016, lisbon, 2016.
    Published
  13. Amaral, A. T.. "Targeting Ewing Sarcoma Cells and the tumor microenvironment with OMTX003 Anti-Endoglin Monoclonal Antibodies". Paper presented in EACR- 24, Manchester, 2016.
    Published
  14. Amaral, A. T.. "Immunophenotype and CD99 Expression Patterns of Human Mesenchymal Stem Cells and Their Implication in Ewing Sarcoma Genesis, Biology and Treatment #954". Paper presented in 22nd Biennial Congress of the European Association for Cancer Research (EACR), Barcelona, 2012.
    Accepted
Conference paper
  1. Voronovska, Anastasiya; Salguero-Aranda, C; Batista, Ana; lobo selma, L.; SOARES-GONÇALVES, JOÃO MANUEL; Lopes-Cardoso, Hugo; Duarte-Azevedo, F.; et al. Corresponding author: Amaral, A. T.. "The Matrix Reloaded: Modeling, Remodeling, and Silencing in Desmoplastic Small Round Cell Tumor". Paper presented in Cancer Cell Plasticity EACR virtual event, 2025.
    In press
  2. Amaral, A. T.. "Abstract PR13: DNA methylation mapping and computational modeling in a large Ewing sarcoma cohort identifies principles of tumor heterogeneity and their impact on clinical phenotypes". Paper presented in AACR Special Conference: Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship, Fort Lauderdale,, 2015.
    Accepted
  3. Amaral, A. T.. "The anti-IGF signaling agents increase the efficacy of Trabectedin in Ewing sarcoma. Oral Presentation.". Paper presented in Growth Hormone & IGF Research, October, 2014.
    Published
Conference poster
  1. Panão-Costa, João; Lopes-Cardoso, Hugo; Mendonça, P. V.; SOARES-GONÇALVES, JOÃO MANUEL; Voronovska, Anastasiya; Vieira-da-Silva, M.; Duarte-Azevedo, F.; et al. "Precision myeloid modulation of the tumor microenvironment: Sugar-functionalized lipid nanoparticles rewire TAM phenotypes". Paper presented in EACR Conference - Cancer Cell Plasticity: Cracking the Code of Adaptation and Survival Virtual Event, 2025.
  2. Vieira-da-Silva, M.; Nikitin, T.; Lopes-Cardoso, Hugo; SOARES-GONÇALVES, JOÃO MANUEL; Voronovska, Anastasiya; Duarte-Azevedo, F.; Panão-Costa, João; et al. "Tracking mitochondria in murine malignant mesothelioma cells using confocal Raman microscopy". Paper presented in EACR Conference - Cancer Cell Plasticity: Cracking the Code of Adaptation and Survival Virtual Event, 2025.
  3. Lopes-Cardoso, Hugo; Mendonça, P. V.; SOARES-GONÇALVES, JOÃO MANUEL; Vieira-da-Silva, M.; Voronovska, Anastasiya; Duarte-Azevedo, F.; J.S., Ferreira,; et al. "Targeting cancer plasticity and therapy resistance with sugar-functionalized mRNA-LNP vaccines". Paper presented in EACR Conference - Cancer Cell Plasticity: Cracking the Code of Adaptation and Survival Virtual Event, 2025.
  4. Amaral, A. T.; Salguero-Aranda, C; Voronovska, Anastasiya; Lopes-Cardoso, Hugo; lobo selma, L.; SOARES-GONÇALVES, JOÃO MANUEL; Duarte-Azevedo, F.; et al. "Mapping the Immuno-Landscape of Desmoplastic Small Round Cell Tumor". Paper presented in Cancer Cell Plasticity: Cracking the Code of Adaptation and Survival, 2025.
  5. SOARES-GONÇALVES, JOÃO MANUEL; Lopes-Cardoso, Hugo; Voronovska, Anastasiya; Duarte-Azevedo, F.; Silva, Maria; Carvalheiro, Catarina; Batista, Ana; et al. Corresponding author: Moreira, João Nuno. "Dendritic Cell Reprogramming in Malignant Pleural Mesothelioma: Unveiling New Therapeutic Possibilities". Paper presented in ASEICA-ASPIC INTERNATIONAL MEETING: New Therapies and Challenges, topics from basic to clinical, 2025.
  6. Batista, Ana; Silva, Maria; Nikitin, Timur; Lopes-Cardoso, Hugo; Voronovska, Anastasiya; SOARES-GONÇALVES, JOÃO MANUEL; Duarte-Azevedo, F.; et al. Corresponding author: Batista, Ana. "Raman Profiling of Lipid Nanoparticles and Live Tumor Cells". Paper presented in SPAOM Meeting 2025, 2025.
  7. Lopes-Cardoso, Hugo; Mendonça, P. V.; SOARES-GONÇALVES, JOÃO MANUEL; Voronovska, Anastasiya; Vareda, João P.; Fonseca, A. C.; Batista, Ana; et al. "Targeted immunotherapy with mRNA cancer vaccines: harnessing sugar-functionalized LNPs for precision antitumor immunity". Paper presented in 20th ASEICA International Congress, Bilbao, Spain, 2025.
  8. Panão-Costa, João; Lopes-Cardoso, Hugo; Mendonça, P. V.; SOARES-GONÇALVES, JOÃO MANUEL; Voronovska, Anastasiya; Vareda, João P.; Fonseca, A.C.; et al. "Sugar-functionalized lipid nanoparticles for targeted reprogramming of tumor-associated macrophages". Paper presented in 20th ASEICA International Congress, Bilbao, Spain, 2025.
  9. Laura Lobo Selma; ana teresa amaral. "The Transcription Factor SNAI2 as a Novel Mediator of EWS-WT1 (+KTS) Oncogenic Activity in Desmoplastic Small Round Cell Tumour. P-238". Paper presented in European Association for Cancer Research (EACR) 2025, 2025.
  10. Duarte-Azevedo, F.; SOARES-GONÇALVES, JOÃO MANUEL; Lopes-Cardoso, Hugo; Voronovska, Anastasiya; Vieira-da-Silva, M.; Batista, Ana; Panão-Costa, João; et al. Corresponding author: Moreira, João Nuno. "Establishing Robust In Vitro and In Vivo Models of Mesothelioma for Enhanced Translational Research". Paper presented in European Association for Cancer Research (EACR) 2025, 2025.
  11. Voronovska, Anastasiya; Laura Lobo Selma; SOARES-GONÇALVES, JOÃO MANUEL; Duarte-Azevedo, F.; Lopes-Cardoso, Hugo; Panão-Costa, João; Batista, Ana; et al. "Modeling extracellular matrix-tumor interactions in desmoplastic small round cell tumor: development of a new organotypic model". Paper presented in European Association for Cancer Research (EACR) 2025, 2025.
  12. Panão-Costa, João; Lopes-Cardoso, Hugo; Mendonça, Patrícia; SOARES-GONÇALVES, JOÃO MANUEL; Voronovska, Anastasiya; Vareda, João P.; Ana c a l fonseca; et al. Corresponding author: Moreira, João Nuno. "mRNA Cancer Vaccines: Leveraging Sugar-Functionalized LNPs for Targeted Antitumor Immunity". Paper presented in European Association for Cancer Research (EACR) 2025, 2025.
  13. Lopes-Cardoso, H; Soares-Gonçalves, J.M.; Voronovska, A.; Duarte-Azevedo, F.; Vieira-da-Silva, M.; Batista, A.; Amaral, A.T.; Panão-Costa, J.; Moreira, J.N.. Corresponding author: Moreira, J.N.. "Impact of aqueous buffer composition on RNA-LNP physicochemical properties". Paper presented in Applied Biophysics Forum in Drug Delivery, 2025.
  14. Batista, Ana; Nikitin, T.; Vieira-da-Silva, M.; Cardoso, Hugo; Voronovska, Anastasiya; Soares-Gonçalves, J.; Panão-Costa, João; et al. Corresponding author: Moreira, João Nuno. "Exploring the Interactions of Lipid Nanoparticles with Tumor Cells using Confocal Raman Microscopy". Paper presented in Applied Biophysics Forum in Drug Delivery, 2025.
  15. Batista, Ana; Nikitin, Timur; Cardoso, Hugo; Voronovska, Anastasiya; Panão Costa, João; Amaral, Ana; Moreira, João Nuno. "Confocal Raman Microscopy for Exploring Lipid-Nanoparticle Intracellular Trafficking in Cancer Cells". Paper presented in Applied Biophysical Forum in Drug Delivery 2024, 2024.
  16. Batista, Ana; Nikitin, Timur; Cardoso, Hugo; Voronovska, Anastasiya; Panão Costa, João; Pedroso Seidy; Amaral, Ana; Moreira, João Nuno. "Towards tracing lipid-nanoparticle intracellular trafficking in cancer cells by confocal Raman microscopy". Paper presented in 6th ASPIC International Congress, 2024.
  17. Amaral, A. T.. "Unraveling gene fusion dependent transcription factors in Desmoplastic Small Round Cell Tumor". Paper presented in ASEICA 40th Anniversary Congress, 2023.
  18. Joaquin Olmedo-Pelayo; Amaral, Ana; Álava, Enrique De. "EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to genotoxic agents by altering R-loop metabolism". Paper presented in IX IBIS Research Forum. Institute of Biomedicine of Seville. 2023. Seville, Spain., 2023.
  19. Lobo-Selma, Laura; Amaral, Ana; Carmen Salguero Aranda; Álava, Enrique De. Corresponding author: Carmen Salguero Aranda. "Unravelling the molecular landscape of Desmoplastic Small Round Cell Tumor". Paper presented in ANNUAL CONGRESS OF THE EUROPEAN ASSOCIATION FOR CANCER RESEARCH EACR 2023, 2023.
  20. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://www.eacr.org/user_uploads/files/2022-Event-Websites/EACR_202. "Desmoplastic Small Round Cell Tumor: modelling the disease (EACR22-0981)". Paper presented in EACR 2022 Congress - Innovative Cancer Science, 2022.
  21. Amaral, A. T.. Corresponding author: Amaral, A. T.. "Exploring the role of Endoglin in the aggressiveness of Ewing and Clear Cell Sarcoma". Paper presented in EACR 2022 Congress – Innovative Cancer Science, 2022.
  22. Amaral, A. T.. "DEREGULATION OF HIPPO TUMOR SUPRESSOR PATHWAY IN EWING SARCOMA". Paper presented in CTOS 2016 — Connective Tissue Oncology Society Annual Meeting; 2016., 2016.
  23. Amaral, A. T.. Corresponding author: Amaral, A. T.. "The cytotoxic activity of Trabectedin, related compounds and PARP inhibitors in mono/combined therapies: in vivo and in vitro studies in Ewing Sarcoma". Paper presented in III Encuentro de Jóvenes Investigadores Red Temática de Investigación Cooperativa en Cáncer RTICC: Red Temática de Investigación Cooperativa en Cáncer, 2014.
  24. Amaral, A. T.; scotlandi, k. "Mechanistic rationale for combining trabectedin with anti-IGF1R agents in ewing sarcoma: evidences of an effective therapy. Poster166. CTOS 2014. Berlin.". Paper presented in CTOS 2014. Berlin, 2014.
  25. Amaral, A. T.. "Immunophenotype and CD99 Expression Patterns of Human Mesenchymal Stem Cells and Their Implication in Ewing Sarcoma Genesis, Biology and Treatment.". Paper presented in 22nd Meeting of the European Association for Cancer Research (EACR), 2012.
Journal article
  1. Olmedo-Pelayo, Joaquin; Granado-Calle, Esperanza; Delgado-Bellido, Daniel; Lobo-Selma, Laura; Jordan-Perez, Carmen; Monteiro-Amaral, Ana T.; Ehlers, Anna C.; et al. "EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism". Oncogene (2025): https://doi.org/10.1038/s41388-025-03496-9.
    Accepted • 10.1038/s41388-025-03496-9
  2. Manasterski, Piotr J.; Danks, Molly R.; Thomson, John P.; Muir, Morwenna; Lee, Martin; Dawson, John C.; Amaral, Ana T.; et al. "Genomics-led approach to drug testing in models of undifferentiated pleomorphic sarcoma". Molecular Oncology (2025): https://doi.org/10.1002/1878-0261.70059.
    10.1002/1878-0261.70059
  3. Delgado-Bellido, Daniel; Zamudio-Martínez, Esteban; Fernández-Cortés, Mónica; Herrera-Campos, Ana Belén; Olmedo-Pelayo, Joaquin; Perez, Carmen Jordán; Expósito, José; et al. "VE-Cadherin modulates ß-catenin/TCF-4 to enhance Vasculogenic Mimicry". Cell Death & Disease 14 2 (2023): https://doi.org/10.1038/s41419-023-05666-7.
    10.1038/s41419-023-05666-7
  4. Ana Amaral; Carmen Salguero Aranda; Joaquín Olmedo-Pelayo; Enrique de Alava; Ana Teresa Amaral; Juan Diaz-Martin. "Genetic Alterations and Deregulation of Hippo Pathway as a Pathogenetic Mechanism in Bone and Soft Tissue Sarcoma". Cancers 14 24 (2022): 6211-6211. http://dx.doi.org/10.3390/cancers14246211.
    10.3390/cancers14246211
  5. Puerto-Camacho, Pilar; Díaz-Martín, Juan; Olmedo-Pelayo, Joaquín; Bolado-Carrancio, Alfonso; Salguero-Aranda, Carmen; Jordán-Pérez, Carmen; Esteban-Medina, Marina; et al. Corresponding author: Amaral, Ana Teresa. "Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell–Matrix Interactions". International Journal of Molecular Sciences 23 15 (2022): 8657. http://dx.doi.org/10.3390/ijms23158657.
    Open access • Published • 10.3390/ijms23158657
  6. Martí, Juan Manuel; Garcia-Diaz, Angel; Delgado-Bellido, Daniel; O'Valle, Francisco; González-Flores, Ariannys; Carlevaris, Onintza; Rodríguez-Vargas, José Manuel; et al. "Selective modulation by PARP-1 of HIF-1a-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions". Redox Biology 41 (2021): 101885. http://dx.doi.org/10.1016/j.redox.2021.101885.
    10.1016/j.redox.2021.101885
  7. González Muñoz, Teresa; Amaral, Ana Teresa; Puerto-Camacho, Pilar; Peinado, Héctor; de Álava, Enrique. "Endoglin in the Spotlight to Treat Cancer". International Journal of Molecular Sciences 22 6 (2021): 3186. http://dx.doi.org/10.3390/ijms22063186.
    10.3390/ijms22063186
  8. "Hippo pathway effectors YAP1/TAZ induce an EWS–FLI1 -opposing gene signature and associate with disease progression in Ewing sarcoma". The Journal of Pathology 250 4 (2020): 374-386. http://dx.doi.org/10.1002/path.5379.
    10.1002/path.5379
  9. "Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape". Cells 9 4 (2020): 804-804. http://dx.doi.org/10.3390/cells9040804.
    10.3390/cells9040804
  10. "Preclinical Efficacy of Endoglin-Targeting Antibody–Drug Conjugates for the Treatment of Ewing Sarcoma". Clinical Cancer Research 25 7 (2019): 2228-2240. http://dx.doi.org/10.1158/1078-0432.ccr-18-0936.
    10.1158/1078-0432.ccr-18-0936
  11. "DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma". Nature Medicine 23 3 (2017): 386-395. http://dx.doi.org/10.1038/nm.4273.
    10.1038/nm.4273
  12. Ordóñez, J.L.; Amaral, A.T.; Carcaboso, A.M.; Herrero-Martín, D.; García-Macías, M.C.; Sevillano, V.; Alonso, D.; et al. "Correction: The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin [Oncotarget, 6, (2015), (18875-18890)]. doi: 10.18632/oncotarget.4303". Oncotarget 8 26 (2017): 43592-43592. https://www.scopus.com/inward/record.url?eid=2-s2.0-85021299522&partnerID=MN8TOARS.
    10.18632/oncotarget.18610
  13. Camacho, P. Puerto; Amaral, A.T.; Ordoñez, J.L.; Robles, M.J.; Domínguez, S.; Peréz, C. Jordán; Biscuola, M.; et al. "Targeting Ewing Sarcoma cells and the tumor microenvironment with OMTX003 anti-endoglin monoclonal antibodies". European Journal of Cancer 61 (2016): S69. https://doi.org/10.1016/s0959-8049(16)61239-x.
    10.1016/s0959-8049(16)61239-x
  14. "Ex vivo identification and characterization of a population of CD13high CD105+ CD45- mesenchymal stem cells in human bone marrow". Stem Cell Research & Therapy 6 1 (2015): http://dx.doi.org/10.1186/s13287-015-0152-8.
    10.1186/s13287-015-0152-8
  15. "The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin". Oncotarget 6 22 (2015): 18875-18890. http://dx.doi.org/10.18632/oncotarget.4303.
    10.18632/oncotarget.4303
  16. "Bone microenvironment signals in osteosarcoma development". Cellular and Molecular Life Sciences 72 16 (2015): 3097-3113. http://dx.doi.org/10.1007/s00018-015-1918-y.
    10.1007/s00018-015-1918-y
  17. "Trabectedin Efficacy in Ewing Sarcoma Is Greatly Increased by Combination with Anti-IGF Signaling Agents". Clinical Cancer Research 21 6 (2015): 1373-1382. http://dx.doi.org/10.1158/1078-0432.ccr-14-1688.
    10.1158/1078-0432.ccr-14-1688
  18. "Characterization of Human Mesenchymal Stem Cells from Ewing Sarcoma Patients. Pathogenetic Implications". PLoS ONE 9 2 (2014): e85814-e85814. http://dx.doi.org/10.1371/journal.pone.0085814.
    10.1371/journal.pone.0085814
  19. "Innovative Therapies in Ewing Sarcoma". Advances in Anatomic Pathology 21 1 (2014): 44-62. http://dx.doi.org/10.1097/pap.0000000000000003.
    10.1097/pap.0000000000000003
  20. "IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis". PLoS ONE 6 5 (2011): e19846-e19846. http://dx.doi.org/10.1371/journal.pone.0019846.
    10.1371/journal.pone.0019846
  21. "The Clinical Relevance of Molecular Genetics in Soft Tissue Sarcomas". Advances in Anatomic Pathology 17 3 (2010): 162-181. http://dx.doi.org/10.1097/pap.0b013e3181d98cbf.
    10.1097/pap.0b013e3181d98cbf
  22. "Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target". British Journal of Cancer 101 1 (2009): 80-90. http://dx.doi.org/10.1038/sj.bjc.6605104.
    10.1038/sj.bjc.6605104
Journal issue
  1. Batista, Ana; Amaral, A. T.. "Advanced Optical Imaging for Tissue and Tumour Characterization". Special issue of Life (Open for Submission) (2025): https://www.mdpi.com/journal/life/special_issues/P02AB01500.
Preprint
  1. Ana Amaral; Daniel Delgado Bellido; Esteban Zamudio-Martínez; Monica Fernandez-Cortes; Ana Belen Herrera-Campos; Joaquin Olmedo-Pelayo; Carmen Jordan-Perez; et al. "VE-Cadherin modulates ß-catenin/TCF-4 to enhance Vasculogenic Mimicry". 2022. http://dx.doi.org/10.21203/rs.3.rs-2069549/v1.
    10.21203/rs.3.rs-2069549/v1

Other

Other output
  1. Hippo pathway effectors YAP1/TAZ induce a EWS-FLI1-opposing gene signature and associate with disease progression in Ewing Sarcoma. 2019. Rodríguez-Núñez, P.; Romero-Pérez, L.; Amaral, A.T.; Puerto-Camacho, P.; Jordán, C.; Marcilla, D.; Grunewald, T.G.P.; de Alava, E.; Díaz-Martín, J.. https://www.scopus.com/inward/record.url?eid=2-s2.0-85095627378&partnerID=MN8TOARS.
    10.1101/589648
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/09/19 Meet the group Innovative Therapies 5th CiBB Retreat
CIBB (Portugal)
2023/11/14 Unraveling gene fusion dependent transcription factors in Desmoplastic Small Round Cell Tumor ASEICA 40th Anniversary Congress,
ASEICA (Coruña, Spain)
2021/12/14 Desmoplastic Small Round Cell Tumor on the spotlight- Senior Author-Oral Presentation Desmoplastic Small Round Cell Tumor on the spotlight
CIBERONC (barcelona, Spain)
2021/12/13 Dissecting the role of Rloops in Ewing sarcoma chemosensitivity- Contributing Author- Face to Face poster IV Young Researchers Meeting CIBERONC-BBN
CIBERONC (barcelona, Spain)
2021 Invited Speaker: Circulating Biomarkers in Sarcomas with Translocations https://www.youtube.com/watch?v=ARO08iHZGBc&t=940s Precision diagnostics and follow-up of sarcoma patients
Asociación Sarcomas de Galicia (Galician Sarcoma Association) ASARGA (Spain)
2018/09/06 Invited Speaker: Why did we choose uveal melanoma as a research project for CIBERONC? https://www.gethi.org/contenidos/apartados/detalleApartado.aspx?idTipoApartado=i2%2F7o8SaukHJdF9r3vmW1Q%3D%3D&idCategoria=vcmxUUdhbPZVNx3%2FeyzeOQ%3D%3D&idApartado=d5XrZo1yr%2BR63bnHoZKy5A%3D%3D I Jornada GETHI CIBERONC
GETHI (Sevilla, Spain)
2017/01/19 The rationale for a combination of lurbinectedin + olaparib in ES EURO EWING Consortium-International Clinical trials to Improve Survival in Ewing Sarcoma EURO EWING Consortium-International Clinical trials to Improve Survival in Ewing Sarcoma
University College London (London, United Kingdom)
2017 Rationale for the combination of Lurbinectedin/Trabectedin with Olaparib (Update) Incorporating EURO-EWING 99 and EWING 2008
EURO EWING Consortium – International Clinical Trials to Improve Survival from Ewing Sarcoma (london, United Kingdom)
2016/09/09 Dual targeting of Ewing sarcoma and the tumor microenvironment PROVABES/EORTC/DKTK/EEC_WP3&4 Meeting
Transcan-2 translational cancer research program (Essen, Germany)
2016 Invited Speaker: The potential application of exosomes in the clinical setting of Ewing Sarcoma
SEAP-IP (Spanish Society of Pathology) (Madrid, Spain)
2014/12/18 Invited Speaker: Transcriptional downregulation of EWSR1-FLI1, induction of DNA damage and anti-IGF1R therapies in the treatment of Ewing Sarcoma http://www.ibis-sevilla.es/media/8087/Memoria_Anual_IBiS_2014.pdf XI Foro de Investigadores. Institute of Biomedicine of Seville
Insituto de Biomedicina de Sevilla (Sevilla, Spain)
2010 Preclinical Evaluation of OSI-906 and Trabectedin effects on Ewing Sarcoma cells 1st Annual Eurosarc Meeting
EUROSARC (Treviso)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2025 - 2029 PhD thesis: Dual-Targeting in Desmoplastic Small Round Cell Tumor Models: Overcoming Matrix Barriers While Abrogating the Fusion Gene
Supervisor of Anastasiya Voronovska
Universidade de Coimbra, Portugal

Instituto de Biomedicina de Sevilla, Spain
2022 - 2026 PhD thesis: Desmoplastic Small Round cell tumor on the spotlight: Comprehensive molecular and functional characterization of new biomarkers and actionable targets
Co-supervisor of Laura Lobo Selma
Programa de doctorado de Biología Molecular, Biomedicina e Investigación Clínica (PhD)
Instituto de Biomedicina de Sevilla, Spain

Universidad de Sevilla, Spain
2024/05 - 2025 MSc thesis: Unlocking Nucleolin as a therapeutic target for functionalized mRNA-Lipid Nanoparticles in mesothelioma in vitro models
Supervisor
Mestrado em Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/09 - 2022/06 Undergraduate thesis: :Genomic and functional studies in clear cell sarcoma models
Co-supervisor
Biomedicina (Degree)
Universidad de Sevilla, Spain
2020 - 2021 Undergraduate thesis; Uveal Melanoma: New Therapeutic Opportunities
Co-supervisor
Medicina y Cirugia (Degree)
Universidad de Sevilla-Facultad de Medicina, Spain
2017 - 2021 PhD thesis: Endoglin in Ewing Sarcoma: from the biological relevance to a clinical strategy
Co-supervisor
Instituto de Biomedicina de Sevilla, Spain
2017 - 2021 PhD thesis: Endoglin in Ewing sarcoma: from the biological relevance to a clinical strategy https://idus.us.es/items/66a80d8b-4845-4886-99e7-c88d946fea09
Supervisor of Maria Pilar Puerto Camacho
PhD in Molecular Biology (PhD)
Instituto de Biomedicina de Sevilla, Spain

Institute of Genetics and Cancer, United Kingdom
2019 - 2020 MSc thesis: New contributions on the Desmoplastic Small Round Cell Tumor: establishment of pre-clinical models for the identification of new targets and biomarkers
Co-supervisor
Máster Universitario Oficial en Investigación Biomédica (Master)
Instituto de Biomedicina de Sevilla, Spain
2018 - 2019 Undergraduate thesis: Endoglin/ALCAM as potential therapeutic targets in Clear Cell Sarcoma and Desmoplastic Small Round Cell Tumor
Co-supervisor
Universidad de Sevilla-Biomedicina (Degree)
2017 - 2018 Undegraduate thesis: Generation of knockout models for ALCAM of Uveal Melanoma and Ewing sarcoma
Co-supervisor
Biomedicina (Degree)
Universidad de LLeida Biomedicina , Spain

Event organisation

Event name
Type of event (Role)
Institution / Organization
2025/09/26 - Current Outreach Activity: European's Research Night Booth: Shine the light in your DNA! https://www.uc.pt/iii/eventos-nei/a-noite-europeia-dos-investigadores-nei-esta-de-volta/ (2025/09/26)
Exhibition (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2025/09/19 - Current Outreach Activity: Sexta da Ciência (2025/09/19)
Exhibition (Member of the Organising Committee)
Universidade de Coimbra, Portugal
2025/03/06 - Current Outreach activity: "O que são as vacinas?" Programa de disseminação na escola primária de S. Martinho do Bispo focado no sistema imunitário, ADN &células e vacinas. (2025/03/06)
Workshop (Member of the Organising Committee)
2025 - Current Outreach activity: "A luz e as suas propriedades" Programa de disseminação no Colégio Bissaya Barreto. (2025)
Workshop (Co-organisor)
2025 - Current Outreach activity: "O que são as vacinas?" Programa de disseminação no Colégio Bissaya Barreto focado no sistema imunitário, ADN &células e vacinas. (2025)
Workshop (Co-organisor)
2023/09 - Current a_b_c_Scientists is an outreach initiative designed to bring engaging, hands-on scientific experiences directly into school environments. The project aims to bridge the gap between classroom learning and real-world scientific practice by involving students, teachers and researchers in dynamic, experiment-based activities (2023/09)
Other (Co-organisor)
2025 - 2026 Coordinator of the Pharmacogenomics Module in the Master’s Program in Pharmaceutical Biotechnology (2025 - 2026)
Other (Member of the Organising Committee)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2024/03/08 - 2024/03/08 Outreach activity at the Almas de Freire Primary School. Workshop: " O que são células?" "Como funcionam as vacinas?" "O que é a luz?" (2024/03/08 - 2024/03/08)
Workshop (Co-organisor)
Universidade de Coimbra, Portugal
2023/02/11 - 2023/02/11 Outreach Activity at the Almas de Freire Priimary School: Workshop: "O que fazem os investigadores?" (2023/02/11 - 2023/02/11)
Workshop (Co-organisor)
Escola Almas de Freire, Santa-Clara, Portugal

Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2025/10/11 - Current “Adolescentes e Jovens Adultos: Viver com Cancro entre Dois Mundos” promovida pela Acreditar - Associação de Pais e Amigos de Crianças com Cancro no âmbito das celebrações do seu 30.º aniversário, que decorreu no dia 11 de outubro de 2025 na Faculdade de Medicina da Universidade de Coimbra. “Adolescentes e Jovens Adultos: Viver com Cancro entre Dois Mundos
Acreditar - Associação de Pais e Amigos de Crianças com Cancro, Portugal

Faculdade de Medicina da Universidade de Coimbra, Portugal
2022/02/11 - Current CaixaResearch: Colaboración Dia Mundial del Cáncer infantil
Workshop
Dia Mundial del Cáncer infantil
Obra Social La Caixa, Spain
2021 - Current Science Fair-Seville. https://twitter.com/LabHuvr/status/1129309616288993280/photo/1
Exhibition
Scince Fair
2020/02/11 - Current Women In Science, February 11. “Meet Our Researchers” Science Dissemination Activities with children and high school students https://twitter.com/LabHuvr/status/1368943413706584073/photo/1
Seminar
Women In Science, February 11. “Meet Our Researchers”
2019 - Current Science Dissemination Activities with children and high school students Science Fair-Seville https://twitter.com/LabHuvr/status/1129309616288993280/photo/1
Workshop
Science Fair-Seville
2017/11 - Current Course on 3D Organoid Culture, IRB, Barcelona
Workshop
course on 3D models
Institut de Recerca Biomèdica, Spain
2015/02/09 - Current Tumor microenvironment in Ewing sarcoma: search for new diagnostic tools and therapeutic approaches: Oral Presentation
Seminar
Seminario Program de Onco-Hematología y Genética
Hospital Universitario Virgen del Rocío, Spain
2013/11/26 - Current Design and development of clinical trials
Workshop
Design and development of clinical trials
Instituto de Investigación Biomédica de Salamanca, Spain
2010/06/29 - Current 21st meeting of the european association for cancer research in Oslo
Conference
21st meeting of the european association for cancer research
European Association For Cancer Research, United Kingdom
2009/12/04 - Current Frontiers in cancer stem cell research: from basic science towards a cure
Conference
Second Norwegian cancer syposium
2025/10/22 - 2025/10/25 EMBL Symposium: Organoids: modelling organ development and disease in 3D
Workshop
EMBL Symposium: Organoids: modelling organ development and disease in 3D
2024/03/05 - 2024/03/05 Outreach activity at the UC Exploratório - Ciência Viva Coimbra for pre-schoolers " O que é o DNA?"
Workshop
" O que é o DNA?"
UC Exploratório - Ciência Viva Coimbra , Portugal
2022/06/20 - 2022/06/23 Desmoplastic Small Round Cell Tumor: modelling the disease Poster Presentation Senior author
Congress
EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine
European Association For Cancer Research, United Kingdom
2021/12/10 - 2021/12/11 100 years Ewing Sarcoma: Learning from the past, Challenges for the future
Congress
100 years Ewing Sarcoma: Learning from the past, Challenges for the future
Sarcoma Patients EuroNet EV, Germany

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2025/03/10 N-terminomics and Proteomics Applied to the Discovery of Prognostic Markers in Biological Samples from Patients with Melanoma (N-terminômica e Proteômica Aplicadas à Descoberta de Marcadores Prognósticos em Amostras Biológicas de Pacientes com Melanoma)
(Thesis) Main arguer
Murilo de Souza Salardani (PhD)
Universidade Federal de São Paulo (UNIFESP) , Brazil
2024/10/20 Unravelling the role of efemp1 in the metastatic cascade of osteosarcoma
(Thesis) Main arguer
Beatriz Isabel Gomes Salgado (Master)
Faculdade de Medicina da Universidade de Coimbra, Portugal
2024/07/10 Unveiling the Future of Immunotherapy through mRNA-LNPs Therapies
(Thesis) Main arguer
Ana Carolina dos Santos Andrade (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/09/26 Cancer Immunotherapy: Current Landscape and Future Directions
(Thesis) Main arguer
Joana Sousa Pereira Nogueira Brito (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2017 - Current Stem Cells
2016 - Current European Journal of Cancer
2018 - 2025 Frontiers in Immunology

Association member

Society Organization name Role
2025/07 - Current Connective Tissue Oncology Society- CTOS Member
2025/05 - Current American Association for Cancer Research (AACR) Active Member
2024 - Current Sociedade Portuguesa de Imunologia - SPI Member
2024 - Current Cientista Regressa à Escola.-Native Scientists Active Member
2022 - Current Associação de Antigos Estudantes da Faculdade de Farmácia da Universidade de Coimbra
2019 - Current Member of the GETHI network. (Spanish group of Orphan and infrequent tumors) Membro
2018 - Current CIBERONC network (Cancer Network Biomedical Research Center), Low Prevalence Tumours Program Membro Adscrito a Grupo de Trabalho
2017 - Current Spanish group for sarcoma research (Grupo GEIS) Membro
2008 - Current Ordem dos Farmacêuticos Mem
2016 - 2020 The European Association for Cancer Research EACR ambassador (From 2016-2020)
2016 - 2020 Associação Portuguesa de Investigação em Cancro ASPIC Membro

Committee member

Activity description
Role
Institution / Organization
2021 - Current Member of a selection jury for senior post-doctoral researchers (1787) for CiBERonc
Member
Centro de Investigación Biomédica en Red, Spain
2019 - Current Member of the Immunology central working
Member
Centro de Investigación Biomédica en Red de Cáncer, Spain
2019 - Current Member of a selection jury for PhD student contract (315/19 HUVR).
Member
Instituto de Biomedicina de Sevilla, Spain
2019 - 2020 Member of a selection jury for senior technician contracts (108/19-HUVR1; 010/20-HUVRI; 084/20-HUVR-1) at the Institute of Biomedidicne of Seville
Member
Instituto de Biomedicina de Sevilla, Spain

Consulting

Activity description Institution / Organization
2025/06/23 - Current Paediatric Bespoke Therapeutic Development Workshop in Desmoplastic Small Round Cell Tumours LifeArc, United Kingdom

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2025/03/01 - Current Master’s in Pharmaceutical Biotechnology – Module VI: Biopharmaceuticals in Clinical Practice (Mestrado Biotecnologia Farmaceutica-Módulo VI: Biofármacos na Prática Clínica) Biotecnologia Farmacêutica (Mestrado integrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2025/02/23 - 2026/02/27 PhD Programme in Experimental Biology and Biomedicine CAR-T cells & Solid Tumors: Pushing the Boundaries of Immunotherapy PHD Programme in Experimental Biology and Biomedicine Universidade de Coimbra, Portugal
2024 - 2024 Master’s in Pharmaceutical Biotechnology – Module VI: Biopharmaceuticals in Clinical Practice (Mestrado Biotecnologia Farmaceutica-Módulo VI: Biofármacos na Prática Clínica) Mestrado em Biotecnologia Farmacêutica (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2023 - 2023 Master’s in Pharmaceutical Biotechnology – Module VI: Biopharmaceuticals in Clinical Practice (Mestrado Biotecnologia Farmaceutica-Módulo VI: Biofármacos na Prática Clínica) Mestrado Biotecnologia Farmaceutica-Módulo VI (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Farmácia, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2025/07/21 - Current External Reviewer Research Projects: Fundación Pública Andaluza Progreso y Salud (CSyC 2025 - Proyectos (RPS 24664))
Evaluator
Fundación Pública Andaluza Progreso y Salud MP, Spain

Universidad de Sevilla, Spain
Fundación Progreso y Salud (FPS), Consejería de Salud, Junta de Andalucía
2025 - Current Special Issue: Advanced Optical Imaging for Tissue and Tumour Characterization Life-MDPI Special Issue Editor
Coordinator
2021 - Current Expert, external reviewer for the Spanish National Research Agency in 22 projects/grants
2022 - 2024 Special Issue: A Roadmap Towards Immunotherapy in Pediatric Tumors Frontiers in Immunology https://www.frontiersin.org/research-topics/50861/a-roadmap-towards-immunotherapy-in-pediatric-tumors
Coordinator

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2026/01/08 "Is talent really written into the DNA we inherit from our parents? Could this microscopic code be the determining factor in our future success and health? Cristiano Ronaldo, one of the greatest soccer players of all time, is often cited as an example of “genetic excellence.” However, neither his parents nor his sisters exhibit comparable characteristics. DNA certainly plays a role—especially in body structure and physiological predispositions—but it is far from telling the whole story." Campeão das Províncias
2025 Portoal de Informação Português de Oncologia Pediátrica (PIPOP) https://pipop.info/2025/08/20/entrevista-a-ana-amaral-responsavel-pelo-projeto-vencedor-da-9-a-edicao-do-premio-rui-osorio-de-castro-millennium-bcp/ Portoal de Informação Português de Oncologia Pediátrica (PIPOP)
2025 Enrique de Álava: Uncovering a Molecular Vulnerability in Ewing Sarcoma https://oncodaily.com/insight/enrique-de-alava-347196 Oncodaily
2021 CAR-T: Células adiestradas para combatir el sarcoma de Ewing Diario de Sevilla
2019 Awarded EACR travel grant for an international short-stay. https://magazine.eacr.org/it-was-a-pleasure-ana-amaral-eacr-travel-fellow/ https://magazine.eacr.org/it-was-a-pleasure-ana-amaral-eacr-travel-fellow/
2018 Working together to help study rare cancers, and expand horizons: Sarcoma Molecular Pathology Team. https://www.icr.ac.uk/research-and-discoveries/cancer-blogs/detail/science-talk/three-ways-global-links-help-our-researchers-carry-out-life-changing-research-on-world-cancer-research-day https://www.icr.ac.uk/research-and-discoveries/cancer-blogs/detail/science-talk/three-ways-global-links-help-our-researchers-carry-out-life-changing-research-on-world-cancer-research-day
2018 https://hospitaluvrocio.es/historico-noticias/un-estudio-sobre-la-eficacia-de-los-medicamentos-conjugados-en-el-tratamiento-del-sarcoma-de-ewing-demuestra-por-primera-vez-que-son-una-opcion-prometedora-para-la-medicina-de-precision/ HUVR
2015 https://www.ibis-sevilla.es/es/noticias/investigacion/actualidad/un-consorcio-de-investigacion-liderado-por-el-hospital-virgen-del-rocio-ibis-halla-en-modelos-animales-una-nueva-opcion-terapeutica-para-ninos-con-sarcoma-de-ewing/ Insituto de Biomedicina de Sevilla

Interview (tv / radio show)

Program Topic
2021 - Current Women In Science, February 11. “Meet Our Researchers”. https://twitter.com/LabHuvr/status/1368943413706584073/photo/1 women in science

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Frontiers in Immunology and Frontiers in Oncology Frontiers
2022/12 - 2023/05 Frontiers in Immunology (1664-3224)

Mentoring / Tutoring

Topic Student name
2025 - Current 2ª edição do Programa de Mentoria - Find Your Career 2024/2025. Matilde Gariso Godinho
2025 - Current Reprogramming in mesothelioma Joãp Manuel Gonçalves
2024 - Current 1ª edição do Programa de Mentoria - Find Your Career 2023/2024 Margarida Raposo

Other jury / evaluation

Activity description Institution / Organization
2025/07/06 - Current Expert Evaluator / Scientific Committee Member: Evaluation of Research Proposals Assessment of Post-Doctoral Fellowships Fundación Progreso y Salud (FPS), Consejería de Salud, Junta de Andalucía Fundación Progreso y Salud (FPS), Consejería de Salud, Junta de Andalucía, Spain
2025 - Current Jury for a position at the Universidade de Coimbra under the call: Graduated students enrolled in a master’s degree, in the scientific area of Data Science and Engineering, Biomedical Engineering, or Engineering Physics #IT137-25-199 Universidade de Coimbra, Portugal
2025 - Current Jury for a position at the Universidade de Coimbra: Master’s degree holders, in the scientific area of Pharmaceutical Biotechnology enrolled in a non-degree-granting course . Knowledge of lipid nanoparticles in the oncological context will be valued #IT137-25-445 Universidade de Coimbra, Portugal
2025 - Current Jury for a position: Master’s degree holders, in the scientific area of Biology enrolled in a non-degree-granting course . Knowledge of lipid nanoparticles in the oncological context will be valued. #IT137-25-444 Universidade de Coimbra, Portugal
2025 - Current Jury for a position: Master’s degree holders, in the scientific area of Pharmaceutical Sciences, enrolled in a non-degree-granting course or a PhD in the field of Pharmaceutical Sciences.. #IT137-25-34 Universidade de Coimbra, Portugal
2025 - Current Jury for a position: Graduates, in the scientific area of Biochemistry, enrolled in a master’s degree #IT137-25-33
2025 - Current Jury for a position: Graduates, in the scientific area of Biology, enrolled in a master’s degree #IT137-25-32 Universidade de Coimbra, Portugal
Distinctions

Award

2025 9ª Prémio Rui Osório de Castro / Millennium bcp
2023 HORIZON-WIDERA-2022-TALENTS-04
European Commission, Belgium
2022 CIBERONC Travel Grant 2022-international fellowship
Centro de Investigación Biomédica en Red de Cáncer, Spain
2019 "Juan de la Cierva" incorporation grant for a Post-Doctoral position
España Ministerio de Ciencia e Innovación, Spain
2018 CIBERONC Travel grant for an international fellowship
Centro de Investigación Biomédica en Red de Cáncer, Spain
2018 EACR travel grant for an international short-stay
European Association For Cancer Research, United Kingdom
2014 Scholarship for the Clinical Trials Master (11th Edition) (1415179)
Universidad de Sevilla, Spain
2010 PhD grant funded by the Fundação para a Ciência e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, Portugal

Title

2020 Good Clinical Practice Certificate
Conserjeria de Salud, Andalucia, Spain
2019 Good Laboratory Practice Certificate
Conserjeria de Salud, Andalucia, Spain
2016 Certificate on Animal protection and experimentation. Bridging course on the design of projects and procedures (Function D in all species groups)
Universidad de Sevilla, Spain
2009 Certificate: 4th training course for experimenters in laboratory animal science (Functions A,B,C)
Conserjería de Agricultura y ganaderia, Gobierno de España, Spain
2008 Certificate of Advanced English C1-ESOL Certificate of Advanced English C1-ESOL University of Cambridge
Cambridge Assessment, United Kingdom

Other distinction

2025 Fee waiver to support virtual attendance at the EMBO | EMBL Symposium: Organoids: Modelling Organ Development and Disease in 3D, Heidelberg, 2025.