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My research interests were kindled early in my academic journey during my Bachelor's degree in Biochemistry at the School of Sciences, University of Minho. It was during this time that I began to explore the intricate role of the Tau protein in neuroplasticity, neuropathology, and potential therapeutic avenues for various brain disorders. Subsequently, during my Master's studies in Health Sciences at the School of Medicine, University of Minho, which I wrapped up in 2021, I continued to explore this +field. Under the mentorship of Dr. Ioannis Sotiropoulos and Dr. Joana Silva, my research endeavors expanded, and I developed a particular interest in the innovative therapeutic platform of Antisense Oligonucleotides (ASOs) for addressing brain conditions associated with Tau pathology, such as Alzheimer's disease (AD), collaborating with RNA Therapeutics Institute in Mass, Boston. In parallel I have also participated in different project from the role of Tau protein in chronic pain, study of Tau's involvement in mitochondrial dynamics, particularly its response to stress conditions, and the physiological role of Tau protein. In my research, I employ a wide range of methodologies, conducting both in vitro studies involving cell lines and primary neuronal cultures, as well as in vivo investigations using mouse models. My toolkit includes various techniques for neuronal and brain analysis, ranging from molecular approaches like qPCR and Western blotting to cellular techniques such as immunofluorescence staining. I also engage in neurostructural analyses, including Golgi-based neuronal reconstruction, and delve into ultrastructural investigations like electron microscopy. Behavioral analyses are an integral part of my research methodology, allowing me to gain a comprehensive understanding of the phenomena under study. At present, I am actively contributing to the field of brain pathology and therapy as a Researcher fellow in Dr. Joana Silva's laboratory at ICVS, University of Minho. I have had the privilege of presenting my research findings at several national and international conferences, including the European Behavioral Pharmacology Society (EBPS) meeting in 2019, the Portuguese Society for Neuroscience (SPN) meeting in 2021, the 1st Symposium on Oligonucleotide technology and Therapeutics in 2021, the ECNP Workshop for Early Career Scientists in Europe in 2023, and the ISN-ESN Meeting in 2023.
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Identification

Personal identification

Full name
CARLOS MANUEL CAMPOS MARQUES

Citation names

  • Campos-Marques, Carlos

Author identifiers

Ciência ID
FD11-8CBB-C91E
ORCID iD
0000-0002-0612-4333

Email addresses

  • id11397@alunos.uminho.pt (Professional)
  • carlos_marques97@hotmail.com (Personal)

Telephones

Mobile phone
  • 912663934 (Personal)

Addresses

  • School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Braga, Portugal (Professional)
  • Rua de Perrelo, 248 - Alvito São Pedro, 4750-088, Barcelos, Braga, Portugal (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2024/04/01 - 2028
Ongoing
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2023/04/17 - 2023/04/21
Concluded
 Advanced Course Proteomics Approaches in Life Sciences (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 16
2022/01/01 - 2022/12/31
Concluded
 Curso de Formação Especializada em Fundamentos para a Investigação Científica (Outros)
Universidade do Minho, Portugal
 18
2018/09/01 - 2021/11/01
Concluded
 Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"A novel RNA-targeted therapeutic approach for Alzheimer’s disease and Down syndrome" (THESIS/DISSERTATION)
 17
2019/04/01 - 2019/04/19
Concluded
 Advanced Course on Pathogenesis of Neurodegenerative Diseases: finding a common ground (Outros)
Universidade do Minho Escola de Medicina, Portugal
 15
2019/01/28 - 2019/02/08
Concluded
 Course on Laboratory Animal Sciences (Outros)
Universidade do Minho Escola de Medicina, Portugal
 17
2015/09/01 - 2018/07/06
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"The role of Tau protein in the neuronal damage induced by neuropathy" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2022/02/21 - Current Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/11 - 2022/02 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/07 - 2018/08 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2020 - Current Uncovering stress-induced mechanisms of Tau pathology in Alzheimer's Disease
NIH_G15190
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 National Institutes of Health Office of Disease Prevention
Concluded
2019 - Current Tau Therapeutics in Down syndrome & Alzheimer's disease synaptic pathologies
520101.ID2021/2017
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fondation Jérôme Lejeune
Concluded

Other

Designation Funders
2019/01/01 - Current The role of Tau protein in mitochondria function and dynamics
R01
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Dioli, Chrysoula; Papadimitriou, Georgia; Megalokonomou, Anastasia; Campos-Marques, Carlos; Sousa, Nuno; Sotiropoulos, Ioannis. "Chronic Stress, Depression, and Alzheimer's Disease: The Triangle of Oblivion". In Advances in Experimental Medicine and Biology - GeNeDis 2022, edited by Panagiotis Vlamos, 303-315. Springer, Cham., 2023.
    Published • https://doi.org/10.1007/978-3-031-31978-5_31
Conference poster
  1. B. Barros-Santos; Gerontidi, Dimitra ; Papadimitriou, Georgia; Nóbrega-Martins, Rita; Campos-Marques, Carlos; Wolozin, Benjamin; Sousa, Nuno; Sotiropoulos, Ioannis; Joana Margarida Silva. "Therapeutic potential of mTOR inhibitor for the clearance of Tau accumulation and RNA-protein granules in stress and Alzheimer’s Disease pathologies". Paper presented in ICVS Retreat 2024, 2024.
  2. Anastasia Megalokonomou; Campos-Marques, Carlos; B. Barros-Santos; Papadimitriou, Zeta; Vamvaka Iakovou, Anastasia; Godinho, Bruno; Watts, Jonathan K; et al. Corresponding author: Anastasia Megalokonomou. "Antisense Oligonucleotides as a novel RNA-targeted therapeutic approach against Tau-driven neuronal malfunction". Paper presented in EPHAR - Federation of European Pharmacological Societies 2024, 2024.
  3. Campos-Marques, Carlos; Godinho, Bruno; Watts, Jonathan K; Sousa, Nuno; Sotiropoulos, Ioannis; Silva, Joana. "A novel RNA-targeted therapeutic approach against Tau-driven neuronal pathology in Alzheimer's and Down syndrome brain pathologies". Paper presented in ISN-ESN Meeting, 2023.
  4. Nóbrega-Martins, Rita; Guedes, Sofia; Udochukwu, Lucian; Santos, Beatriz; Campos-Marques, Carlos; Silva, Iara; Maciel, Patrícia; et al. "Therapeutical potential of tauroursodeoxycholic acid in stress-related brain pathologies". Paper presented in ISN-ESN 2023 Meeting, 2023.
  5. Campos-Marques, Carlos; Bruno Godinho; Jonathan K Watts; Nuno Sousa; Joana M Silva; Ioannis Sotiropoulos. "A novel RNA-targeted therapeutic approach for Alzheimer's disease and Down syndrome brain pathologies". Paper presented in ECNP Workshop for Early Career Scientists in Europe, 2023.
  6. Campos-Marques, Carlos; Bruno Godinho; Jonathan K Watts; Nuno Sousa; Joana M Silva; Ioannis Sotiropoulos. "A novel RNA-targeted therapeutic approach for Alzheimer's disease and Down syndrome brain pathologies". Paper presented in 2nd Symposium on Alzheimer's Disease, 2023.
  7. Campos-Marques, Carlos; Bruno Godinho; Jonathan K Watts; Nuno Sousa; Joana M Silva; Ioannis Sotiropoulos. "Antisense oligonucleotides against Tau pathology". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  8. Campos-Marques, Carlos; Bruno Godinho; Jonathan K Watts; Nuno Sousa; Joana M Silva; Ioannis Sotiropoulos. "A novel RNA-targeted therapeutic approach for Alzheimer's disease and Down Syndrome brain pathologies". Paper presented in 1st Symposium on Oligonucleotide Technologies and Therapeutics, 2021.
  9. Campos-Marques, Carlos; Bruno Godinho; Jonathan K Watts; Nuno Sousa; Joana M Silva; Ioannis Sotiropoulos. "Antisense oligonucleotides as a new therapeutic approach for Tau-driven neuronal malfunction". Paper presented in Neuroscience Research Domain Retreat 2020, 2020.
  10. Campos-Marques, Carlos; Chrysoula Dioli; Ioannis Sotiropoulos. "Tau protein controls mitochondrial function through fusion-related mechanisms". Paper presented in Neuroscience Research Domain Retreat 2019, 2019.
  11. Campos-Marques, Carlos; Joana M Silva; Ioannis Sotiropoulos. "A novel RNA-targeted therapeutic approach for Alzheimer's disease". Paper presented in EBPS Biennal Meeting, 2019.
Journal article
  1. Campos-Marques, Carlos; Dioli, Chrysoula; Silva, Joana M.; Papadimitriou, Georgia; Rego, Ana Cristina; Sotiropoulos, Ioannis. "Absence of Tau protein triggers pro-fusion mitochondria status". (2023):
    Submitted
  2. Campos-Marques, Carlos; Sotiropoulos, Ioannis; Silva, Joana M.. "Brain plasticity and behavioral deficits in Down syndrome: "space" for therapeutic intervention?". (2023):
    Submitted
  3. Silva, Joana M.; Lahiri, S; Monteiro-Fernandes, Daniela; Soares-Cunha, Carina; Mezarino, Victor Solis; Voelker-Albert, Moritz; Gomes, Patrícia; et al. "Reduction of Tau in the adult brain dysregulates epigenetic homeostasis and neuroplasticity". Nature Genetics (2023):
    Submitted
  4. Campos-Marques, Carlos; Godinho, Bruno; Soares-Cunha, Carina; Lee, Jonathan; Wagh, Atish A; Samiotaki, Martina; Silva, Joana M.; Watts, Jonathan K; Sotiropoulos, Ioannis. "Screening of novel ASOs against Tau protein - shifting isoforms". (2023):
    Submitted
  5. Guerreiro, Sara R.; Guimarães, Marco R.; Silva, Joana M.; Dioli, Chrysoula; Vamvaka-Iakovou, Anastasia; Sousa, Raquel; Gomes, Patrícia; et al. "Chronic pain causes Tau-mediated hippocampal pathology and memory deficits". Molecular Psychiatry 27 11 (2022): 4385-4393. http://dx.doi.org/10.1038/s41380-022-01707-3.
    Published • 10.1038/s41380-022-01707-3
Thesis / Dissertation
  1. "A novel RNA-targeted therapeutic approach for Alzheimer’s disease and Down syndrome". Master, Universidade do Minho Escola de Medicina, 2021. https://hdl.handle.net/1822/80964.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/05 - 2023/07 Tau targeting ASOs against Down Syndrome Pathology
Co-supervisor of Adriana Filipa Alves da Cunha
 Bioquímica (Degree)
Universidade do Minho, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/09 - 2024/05 Pint of Science is a worldwide science festival which brings researchers to your local pub/cafe/space to share their scientific discoveries with you - no prior knowledge required. (2023 - 2024)
Festival (Member of the Organising Committee)
 Pint of Science Portugal, Portugal
2022/09 - 2023/05 Pint of Science is a worldwide science festival which brings researchers to your local pub/cafe/space to share their scientific discoveries with you - no prior knowledge required. (2023/05/22 - 2023/05/24)
Festival (Member of the Organising Committee)
 Pint of Science Portugal, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/03/16 - 2023/03/19 The ECNP Workshop aims to stimulate high-quality experimental and clinical research in brain disorders and their treatments by promoting and encouraging the development of Early Career Scientists seeking to pursue research careers in neuropsychopharmacology.
Workshop
 ECNP Workshop for Early Career Scientists in Europe
European College of Neuropsychopharmacology, Netherlands
2022/05/09 - 2022/05/11 Pint of Science is a worldwide science festival which brings researchers to your local pub/cafe/space to share their scientific discoveries with you - no prior knowledge required.
Festival
Pint of Science Portugal, Portugal

Association member

Society Organization name Role
2023/01 - Current International Society for Neurochemistry Member

Mentoring / Tutoring

Topic Student name
2022/09 - Current MSc in Molecular Genetics - Project "The role of RNA granules and TIA-1 in stress-related brain pathologies" Beatriz Barros dos Santos
2023/05 - 2023/07 BSc in Biochemistry - Project "Tau accumulation and RNA-protein granules in Down Syndrome and Alzheimer's brain pathology" Matilde Sofia Antunes Gens
2022/05 - 2022/07 BSc in Applied Biology - Project "Tau targeting ASOs therapy against Down Syndrome brain pathology" Henrique Alves Gomes
2022/05 - 2022/07 BSc in Applied Biology - Project "The effect of chronic stress on brain pathology" Mariana Vivas Pereira
2022/05 - 2022/07 BSc in Biochemistry - Project "The unique Biology of RNA granules - the role of Tau protein" José Duarte Gomes
Distinctions

Other distinction

2023 Travel Grant for ECNP Workshop for Early Career Scientists in Europe
European College of Neuropsychopharmacology, Netherlands