Márcio Alexandre Filipe Simão (F819-2D45-A17F)

Curriculum Vitae

Márcio Alexandre Filipe Simão

I have a Biochemistry degree (Pre-Bologna) and a specialization in Molecular Biology with a master degree in molecular biology, and microbiology obtained at the University of Algarve (UALG). From 2013 to 2017, I was enrolled in the PhD programme in Biomedical Sciences at UALG. Meanwhile I have been working as invited Professor in the Faculty of Medicine and Biomedical Sciences (FCMA) in University of Algarve, teaching Cell Biology, Cell Differentiation and Microenvironments, and created a new discipline, Laboratories in Biomedicine, for the master in biomedical sciences-mechanisms of diseases. This discipline aims to promote students to develop its own mini-research project based on basic background methods and reagents available in the university. In addition, is proposed to students develop the experimental design, execute experiments and present their results. In addition, I am involved in the Lab-It - Itinerant Laboratory within KCITAR-Algarve project, promoting the development of molecular biology activities for students and teacher training in Algarve high schools. As a researsher I have initiated my scientific career with a fellowship in a biogeochemistry project about oxygen dynamic coupled to organic carbon in intertidal areas and done my graduation thesis in research about bioturbation of iron biogeochemistry and in molecular response of the clam Ruditapes decussates upon Perkinsus olseni Infection, which allowed the publication of a paper. After I was a fellowship reseacher in a project which aimed to identificaty and characterize genes involved in synthesis of isoprenoids in parasite Perkinus olseni. For the master thesis my research project was related with the expression of four new ferritins from grooved carpet shell clam Ruditapes decussatus challenged with Perkinsus olseni and metals (Cd, Cu and Zn), which leaded a new publication. After a masther thesis I have done a pause in research activities and was involved for 3 years in project Lab-It development which aimed to support secondary schools and teachers in the formation and dissemination of concepts associated with molecular genetics. Following my scientific interest I was able be recipient of a FCT PhD fellowship (SFRH/BD/77056/2012) with the project “Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with Hereditary Hemochromatosis”. It was developed under the supervision of Professors Leonor Cancela (BIOSKEL lab, at UALG), Ea Hang Korng (INSERM U1132, BIOSCAR at Hôpital Lariboisière, service de Rhumatologie, Université Paris 7 Denis Diderot, Paris, France) and Graça Porto (I3S Research Center at University of Porto, Portugal. The work focused on the study of osteoarthritis and osteoporosis associated to hereditary hemochromatosis using mice models for the molecular characterization of musculoskeletal complications. Part of this work was done at INSERM U1132 (Paris) and at I3S, Porto thus allowing the establishment of external national and international collaborations. I have been accumulating experience in research of osteoarthritis and osteoporosis associated to iron overload phenotypes with knowhow in histological approaches for characterization of cartilage and bone tissues and micro computerized tomography (micro-CT) technique for bone histomorphometric analysis and in the development of primary cultures of mammalian osteoblasts and chondrocytes, in fluorescent and confocal microscopy and in molecular biology techniques. I have also experience in coordinating the research projects of undergraduate and master students from biochemistry, biomedical sciences and medical degrees, as well as in dissemination of science, being responsible Lab-It practical session application in schools and invited to several seminars about molecular genetics in biomedicine. In addition, in the last 3 years I was invited to review more than 40 manuscripts for international research journals.

Read full resume ↓

Identification

Personal identification

Full name: Márcio Alexandre Filipe Simão

Citation names

Simão, Márcio

Author identifiers

Ciência ID: F819-2D45-A17F
ORCID iD: 0000-0001-9658-0895
Researcher Id: AAC-3877-2019

Email addresses

masimao@ualg.pt (Professional)

Telephones

Telephone

(00351) 289800900 Ext.: 7217 (Professional)

Addresses

CCMAR. Laboratório de Biologia Molecular 2.13 - Edifício 7- Campus Gambelas , 8005-139, Gambelas-Faro, Faro, Portugal (Professional)

Websites

https://ccmar.ualg.pt/users/marciosimao (Scholar)
https://publons.com/researcher/3079614/marcio-simao/ (Scholar)

Knowledge fields

Natural sciences - Biological Sciences
Medical and Health Sciences - Basic Medicine
Natural sciences - Biological Sciences

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Intermediate (B1)	Elementary (A2)	Intermediate (B1)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Elementary (A2)	Intermediate (B1)

Education

	Degree	Classification
2017/05/24 Concluded	Doutoramento em Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal "Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with Hereditary hemochromatosis" (THESIS/DISSERTATION)	Muito Bom por unanimidade
2010/10/29 Concluded	Biologia Molecular e Microbiana (120 ECTS) (Mestrado) Universidade do Algarve, Portugal "Identificação e caracterização de duas isoformas da Ferritina da amêijoa R. decussatus e avaliação de algumas das suas propriedades biológicas." (THESIS/DISSERTATION)	17
2006/12/14 Concluded	Bioquímica (pré-bolonha- 240 ECTS) (Licenciatura) Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal "Resposta molecular da amêijoa Ruditapes decussatus à infecção do parasita Perkinsus olseni e a sua possível relação com a dinâmica biogeoquímica do Ferro em sedimentos inter-mareais" (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2004/09/01 - Current	Researcher (Research)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
	Centro de Ciências do Mar, Portugal
2019/03/01 - 2019/05/31	Postdoc (Research)	Instituto Gulbenkian de Ciência, Portugal
	Instituto Gulbenkian de Ciência, Portugal
2009/05/04 - 2009/11/30	Contracted Researcher (Research)	Centro de Ciências do Mar, Portugal

2008/07/01 - 2009/03/31	Research Trainee (Research)	Centro de Ciências do Mar, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal
2007/11/01 - 2008/01/31	Contracted Researcher (Research)	Centro de Electronica Optoelectrônica e Telecomunicacoes, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal
2006/06/01 - 2007/10/31	Research Trainee (Research)	Centro de Ciências do Mar, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal
2005/04/02 - 2006/04/20	Research Trainee (Research)	Universidade do Algarve Centro de Investigação Marinha e Ambiental, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2018/10/11 - Current	Invited Assistant Professor (University Teacher)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal

Others

	Category Host institution	Employer
2012/01/02 - 2017/05/24	Doutoramento em Ciências Biomédicas	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal (...)
2010/02/01 - 2012/01/31	Técnico Superior responsável pela implementação de Aulas práticas de genética molecular no ensino secundário	Universidade do Algarve - Campus de Gambelas, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal

Projects

Grant

	Designation	Funders
2025/02/01 - Current	Rescuing functional defects in a zebrafish model of CDKL5 deficiency CDKL5-22-103-02 Researcher Centro de Ciências do Mar, Portugal	Loulou Foundation -CDKL5 PROGRAM OF EXCELLENCE GRANT PROGRAM- Orphan Disease Center University of Pennsylvania Ongoing
2012/02/01 - 2017/05/24	Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with Hereditary hemochromatosis SFRH/BD/77056/2011 PhD Student Fellow Centro de Ciências do Mar, Portugal Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2024/06/01 - Current	Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using zebrafish models 2022.06526.PTDC Researcher Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia
2021/01/01 - 2025/12/31	Centre for Marine and Environmental Research LA/P/0101/2020 10.54499/LA/P/0101/2020 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade do Algarve Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/09/15 - 2024/06/01	Understanding the pathophysiology of Keutel Syndrome: A path towards cure EJPRD/0004/2019 Researcher Universidade do Algarve, Portugal	European Joint Programme on Rare Diseases Ongoing
2019/11/01 - 2021/12/31	KCITAR ALGARVE ALG-64-2018-23 Other Universidade do Algarve, Portugal	European Social Fund Universidade do Algarve Algarve STP- Parque de Ciência e Tecnologia do Algarve CRESC Algarve 2020 (Programa Operacional do Algarve) Ongoing
2019/03/01 - 2019/05/31	Reversing the pathophysiology of Perkinsosis in clams hatcheries through the use of analogues of Artemisinin PTDC/MAR-BIO/4132/2014 Post-doc Fellow Fundação Calouste Gulbenkian, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/02/01 - 2012/01/31	Laboratório itinerante de Genética Molecular (Lab-IT) LAB-IT LABORATÓRIO ITINERANTE EM GENÉTICA MOLECULAR / INPI Research Fellow Universidade do Algarve - Campus de Gambelas, Portugal	Ciência Viva Comissão de Coordenação e Desenvolvimento Regional do Algarve Concluded
2009/04/02 - 2009/11/12	PTARGET- Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets FCT/POCI/CVT/57982/2004 Research Technician Fellow Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004/04/02 - 2005/04/20	Oxygen dynamic coupled with organic carbon mineralization in inter-tidal sandy zones POCTI/CTA/47048/2002 Scientific Initiation Fellow Universidade do Algarve Centro de Investigação Marinha e Ambiental, Portugal	Concluded

Other

	Designation	Funders
2007/11/01 - 2008/01/31	Premio Ceratónia/CGD 2006 prémio na área científica de Telecomunicações e Electrónica “Microelectronic circuits to monitor cells” 25K€ Premio Ceratónia/CGD 2006 Research Fellow Centro de Electronica Optoelectrônica e Telecomunicacoes, Portugal	Caixa Geral de Depositos Concluded

Outputs

Publications

Conference poster	Simão, Márcio; Giovanni do Carmo; Kussaba Miguel, Larissa; Conceição, Natércia; Gavaia, Paulo J; Leonor Cancela. "Analysis of the impact of mgp_¿10 mutation on zebrafish bone metabolism". Paper presented in V International Meeting of the Portuguese Society of Genetics, 2024. Simão, Márcio; Geraldo, Linda; Rodrigues, Carolina ; Conceição, Natércia; Gavaia, Paulo J; Venkatesan, Jagadeesh K. ; Cucchiarini, Magali ; Leonor Cancela. "rAAV-mediated transduction of ATDC5 and Saos-2 cells with mutant Matrix Gla Protein (MGP) transcripts showed the impact of Gla domain and Serine phosphorylation on the inhibition of mineralization". Paper presented in Ectopic calcification: Friend or foe? Anual INTEC meeting, 2024. Sares, Daniel; Simão, Márcio; Martins, Gil; Cucchiarini, Magali ; Venkatesan, Jagadeesh K. ; Leonor Cancela; Gavaia, Paulo J. "Analysis of mineralization phenotypes in zebrafish larvae expressing a dominant negative mgp mutant". Paper presented in Ectopic calcification: Friend or foe? Anual INTEC meeting, 2024. Larissa Miguel; Simão, Márcio; Conceição, Natércia; Cancela, ML. "Histological characterization of zebrafish mgp mutant (MGP_delta18)". Paper presented in IX Workshop de Bioquímica Clínica, 2024. Linda Geraldo; Kussaba Miguel, Larissa; Conceição, Natércia; João Santos; Jagadeesh K. Venkatesan; Magali Cucchiarini Madry; Simão, Márcio; Leonor Cancela. "rAAV-mediated overexpression of Gla-deficient mutant Matrix Gla Protein limits its potential to inhibit mineralization in SaOS2 cells". Paper presented in IX Workshop de Bioquímica Clínica, 2024. Simão, Márcio; Miguel, Larissa; Conceição, Natércia; Santos, João; Cancela, M. Leonor. "Bioinformatic characterization of two MGP mutant proteins expressed in zebrafish (Danio rerio).". Paper presented in IV International Meeting of the Portuguese Society of Genetics, October 19-20, Braga, Portugal, 2023. Lázaro, Mafalda; Cancela, M. Leonor; Simão, Márcio. Corresponding author: Simão, Márcio. "Characterization of the expression of ZFP36L1 gene within a context of osteoarthritis and osteoporosis pathogenesis". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. Simão, Márcio; Conceição, Natércia; Leonor Cancela. "Impact of Lab-it to consolidate molecular genetics concepts in high schools within the context of Biomedical sciences". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022. Silva, Joel M.; Simão, Márcio; Cancela, M. Leonor. "Molecular characterization of regulatory elements in the 5'- and 3'- UTRs of Bmpr1a transcripts". Paper presented in Annual Meeting of the Portuguese Society of Human Genetics, 2020. M. Kyla Shea; Stephanie G. Harshman; Sarah L. Booth; Donald Smith; Cathy S. Carlson; Lindsey Harper; M. Leonor, Cancela; Simão, Márcio; Richard F. Loeser. "The effect of vitamin K insufficiency on the development of osteoarthritis in aging mice". Paper presented in American Society of Nutrition meeting -NUTRITION 2020 LIVE ONLINE, 2020. Felício, Daniela; Camacho, António; Cancela, M. Leonor; Simão, Márcio. "Identification and characterization of polymorphisms in HLA-B27 allele in ankylosing spondylitis patients". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Silva, Joel; Cerqueira, Manuel; Simão, Márcio; Cancela, M. Leonor. "Characterization of 5' and 3' UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. Felício, Daniela; Camacho, António; Cancela, M. Leonor; Simão, Márcio. "Bioinformatic analysis and characterization of pathogenic mutations on HLA-B27 alleles and its putative implications on protein structure". Paper presented in III Jornadas do Algarve Biomedical Center (ABC), 2019. Simão, Márcio; Camacho, António; Ostertag, Ágnes; Cohen-Solal, Martine; Pinto, I. Jorge; Porto, Graça; Ea, Hang-Korng; Cancela, M. Leonor. "Iron enriched diet in association with Hfe loss of function promote iron toxicity mechanism and accelerate bone loss phenotype". Paper presented in Free Radical Biology & Medicine biennial meeting, 2018. ESTREMORES, BEATRIZ; Simão, Márcio; Gavaia, Paulo J; Cancela, M. Leonor. "Phylogenetic and molecular characterization of Slc39a14 (Zip14) zinc transporter in Danio rerio". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB), 5th Conference, 2018. Simão, Márcio; Pinto, I. Jorge; Porto, Graça; Ea, Hang-Korng; Cohen-Solal, Martine; Cancela, M. Leonor. "Iron enriched diet is a determinant factor for osteoporosis onset and progression in hereditary hemochromatosis mouse model (Hfe-KO)". Paper presented in 4th Barcelona PhD Students Symposium- Science fights back: Tackling disease to recover homeostasis., 2015. Simão, Márcio; Gavaia, Paulo J; Ea, Hang-Korng; Pinto, I. Jorge; Cancela, M. Leonor. "Chondrocytes from a hemochromatosis mouse model reveal altered expression of genes associated to iron and cartilage metabolisms". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014. Simão, Márcio; Gavaia, P; Pinto, I. Jorge; Ea, Hang-Korng; Cancela, M. Leonor. "Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism". Paper presented in European Calcified Tissue Society (ECTS) Congress, 2013. Carvalho, Filipe R.; Cardeira, João; Simão, Márcio; Gavaia, Paulo J; Cancela, M. Leonor. "Inducing a transient diabetic phenotype in zebrafish: can this model be used to study insulin related changes in bone metabolism?". Paper presented in Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB) 4th Conference, 2013. Simão, Márcio; Leite, Ricardo B.. "Identification and characterization of two Ferritin isoforms in clam R. decussatus and evaluation of their Fe2+ oxidation potential". Paper presented in XVII Congresso Nacional de Bioquímica, 2010. Ricardo B. Leite; Luís Fonseca; Ricardo Afonso; Simão, Márcio; Rita Ascenso; M. Leonor Cancela. "Clam Lectins: Species-specific patterns of expression upon perkinus exposure: Evolutionary considerations". Paper presented in Final Assembly of Marine Genomics Europe (MGE), 2008. Ricardo B. Leite; Ricardo Afonso; Simão, Márcio; Sandra Joaquim; Domitília Matias; M. Leonor Cancela. "Evaluation of Perkinsus infection levels within a Variable Range of Temperatures and Salinities in Clam Ruditapes decussatus. Effect on Clam Oxidative Stress and Expression of Antioxidant-related genes". Paper presented in WOPER (Workshop for the Analysis of the Impact of Perkinsosis to the European Shellfish Industry), 2007. Simão, Márcio; Ricardo B. Leite; Ricardo Afonso; Sandra Joaquim; Domitília Matias; M. Leonor Cancela. "Evaluation of Oxidative Stress Levels and Antioxidants mRNA Expression within a Variable Range of Temperatures in Clam Ruditapes decussatus". Paper presented in Congresso Nacional de Bioquímica, 2006. Ricardo B. Leite; Ricardo Afonso; Rita Ascenso; Simão, Márcio; M. Leonor Cancela. "Effect of Perkinsus infection on expression of Ruditapes decussatus biomarkers genes in response to environmental pollutants". Paper presented in Marine Genomics International Congress, 2005. Simão, Márcio; Ricardo B. Leite; M. Leonor Cancela; Carlos Rocha. "Effect of iron dynamics stress on the response of clam R. decussatus to an infection by the protozoan parasite Perkinsus olseni". Paper presented in 2nd International Congress on Stress Responses in Biology and Medicine, 2005. Simão, Márcio; Cancela; M. Leonor; Leite; Ricardo B.; Rocha; Carlos. "A preliminary study of the effect of benthic iron dynamics on the response of the clam R. decussatus to an infection by the protozoan parasite Perkinsus atlanticus /olseni". Paper presented in XIV Congresso Nacional de Bioquímica, Vilamoura*, 2004.
Journal article	Patrícia Diogo; Gil Martins; Márcio Simão; Ana Marreiros; Ana Catarina Eufrásio; Elsa Cabrita; Paulo Jorge Gavaia. "Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24087035. 10.3390/ijms24087035 Márcio Simão; Natércia Conceição; Susana Imaginário; João Amaro; Maria Leonor Cancela. "Lab-It Is Taking Molecular Genetics to School". BioChem (2022): https://doi.org/10.3390/biochem2020011. 10.3390/biochem2020011 Márcio Simão; M. Leonor Cancela. "Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms". Biochemical Society Transactions (2021): https://doi.org/10.1042/BST20200672. 10.1042/BST20200672 Márcio Simão; Ricardo B. Leite; M. Leonor Cancela. "Expression of four new ferritins from grooved carpet shell clam Ruditapes decussatus challenged with Perkinsus olseni and metals (Cd, Cu and Zn)". Aquatic Toxicology (2020): 105675-105675. https://doi.org/10.1016/j.aquatox.2020.105675. 10.1016/j.aquatox.2020.105675 M. Kyla Shea; Sarah L. Booth; Stephanie G. Harshman; Donald Smith; Cathy S. Carlson; Lindsey Harper; Alexandra R. Armstrong; et al. "The effect of vitamin K insufficiency on histological and structural properties of knee joints in aging mice". Osteoarthritis and Cartilage Open (2020): https://doi.org/10.1016/j.ocarto.2020.100078. 10.1016/j.ocarto.2020.100078 Márcio Simão; Paulo J. Gavaia; António Camacho; Graça Porto; I. Jorge Pinto; Hang-Korng Ea; M. Leonor Cancela. "Intracellular iron uptake is favored in Hfe -KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype". BioFactors (2019): https://doi.org/10.1002/biof.1520. 10.1002/biof.1520 Simão M; Camacho A; Ostertag A; Cohen-Solal M; Pinto IJ; Porto G; Hang Korng E; Cancela ML. "Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis.". PloS one (2018): http://europepmc.org/abstract/med/30427936. 10.1371/journal.pone.0207441 Camacho, A.; Simão, M.; Ea, H.-K.; Cohen-Solal, M.; Richette, P.; Branco, J.; Cancela, M.L.. "Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress". Osteoarthritis and Cartilage 24 3 (2016): 494-502. http://dx.doi.org/10.1016/j.joca.2015.09.007. Camacho, António; Funck-Brentano, Thomas; Simão, Márcio; Cancela, Leonor; Ottaviani, Sébastien; Cohen-Solal, Martine; Richette, Pascal. "Effect of C282Y Genotype on Self-Reported Musculoskeletal Complications in Hereditary Hemochromatosis". PLOS ONE 10 3 (2015): e0122817. http://dx.doi.org/10.1371/journal.pone.0122817. 10.1371/journal.pone.0122817 Simão, M.F.; Leite, R.B.; Rocha, C.; Cancela, M.L.. "Changes in bioturbation of iron biogeochemistry and in molecular response of the clam ruditapes decussates upon perkinsus olseni infection". Archives of Environmental Contamination and Toxicology 59 3 (2010): 433-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957969737&partnerID=MN8TOARS. 10.1016/j.joca.2015.09.007
Thesis / Dissertation	Simão, Márcio. "Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with Hereditary hemochromatosis". PhD, Universidade do Algarve - Campus de Gambelas, 2017. Simão, Márcio Alexandre Filipe. "Identificação e caracterização de duas isoformas da Ferritina da amêijoa R. decussatus e avaliação de algumas das suas propriedades biológicas". 2011. http://hdl.handle.net/10400.1/2655. Simão, Márcio. "Molecular response of Ruditapes decussatus clam to Perkinsus olseni parasite infection and its relation with the iron biogeochemistry in inter-tidal sediments.". Degree, Universidade do Algarve - Campus de Gambelas, 2006.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/10/13	Molecular mechanisms associated with iron-related musculoskeletal complications	ABC Days – V Encontro Anual do Algarve Biomedical Center, “Aging Challenges” Algarve Biomedical Center (ABC) (Sagres, Portugal)
2021/10/15	Lab-it is taking molecular genetics to school	XXI National Congress of Biochemistry University of Évora (Évora, Portugal)
2019/10/31	HFE loss of function is a susceptibility factor for bone loss and early osteoporosis onset	11th Symposium in Metabolism, "Ageing & Metabolism", Porto Universidade do Porto, faculdade de Medicina (Porto, Portugal)
2018/03/16	Characterization of osteoarthritis associated with Hereditary Hemochromatosis using Hfe-KO mouse e model	II Jornadas do Algarve Biomedical Center (ABC) Algarve Biomedical Center (ABC), Universidade do Algarve (Olhão, Portugal)
2014/10/23	Characterization of The Histological And Morphological Profile Of Articular Damage In A Hemochromatosis Mouse Model	34th Congress of the Portuguese Society of Orthopaedics and Traumatology in Algarve Portuguese Society of Orthopaedics and Traumatology (Albufeira, Portugal)
2014/07/21	CSI and Prenatal Diagnosis to Teach Molecular Biology: Lab-it – itinerant laboratory	CSI and Prenatal Diagnosis to Teach Molecular Biology: Lab-it – itinerant laboratory HSCI’2014: Science Education with and for Society (Aveiro, Portugal)
2008/07/06	Non-invasive monitoring of bone tissue growth in culture using polymer functionalized microelectrode arrays	International Conference on Science and Tecnology of Syntehetic Metals (ICSM) Science and Technology of Synthetic Metals (Porto de Galinhas, Pernambuco, Brazil)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/09/01 - 2025/09/30	Functional characterization of Matrix Gla protein (MGP) domains and its role on mineralization affecting different pathological contexts Supervisor	Biomedical Sciences -Disease Mechanisms (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal Universidade do Algarve, Portugal
2024/04/01 - 2024/07/25	Overexpression of Matrix Gla protein (MGP) WT and mutated in ATDC5 cells and evaluation of its impact on mineralization Supervisor	Licenciatura Biomedical Sciences (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/04/01 - 2024/07/22	Potential Prognosis and Diagnostic Value of MEF2C in Colorectal Cancer Co-supervisor	Biomedical Sciences (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/02/01 - 2024/07/18	Musculoskeletal analysis of mgp_delta_10 mutant zebrafish Supervisor	Biomedical Sciences (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/04/01 - 2024/06/28	Caracterização histopatológica dos olhos do peixe-zebra homozigótico para a mutação mgp ¿10 e mgp ¿18 Supervisor	Bioengenharia (Degree) Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal
2024/04/01 - 2024/06/28	Caracterização histopatológica dos olhos do ratinho Mgp-knockout Co-supervisor	Bioengenharia (Degree) Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal
2022/09/20 - 2023/10/01	Molecular, functional and morphological characterization of zebrafish mutants associated with the Keutel syndrome Supervisor of Larissa Kussaba Miguel	Biomedical Sciences -Disease Mechanisms (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/09/20 - 2023/10/01	Zebrafish as a model to assess the effects of thalidomide in limb development Co-supervisor of Ana Portela	Molecular and Microbial Biology (Master) Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal
2021/09/15 - 2022/09/30	Characterization of ZFP36L1 gene expression associated with osteoarthritis and osteoporosis pathogenesis mechanisms Supervisor of Mafalda Lázaro	Biomedical Sciences-disease mechanisms (Master) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/04/01 - 2022/07/20	The impact of excess iron on the onset of Alzheimer's disease Supervisor of André Ferreira	Ciências Biomédicas (Degree) Universidade do Algarve, Portugal
2019/06/01 - 2020/09/01	Characterization of 5’ and 3’ UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism Supervisor	Molecular Biology and Microbiology (Master) Universidade do Algarve, Portugal
2019/10/01 - 2020/05/01	Identification and characterization and phylogeny of Bmpr1aa and Bmpr1ab 3’ UTR alternative transcripts in Danio rerio Supervisor of Manuel Cerqueira	Biomedical Sciences (Degree) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2019/02/01 - 2019/07/20	Espondilite Anquilosante: Identificação de polimorfismos no alelo HLA-B27 e possíveis suscetibilidades dos hábitos alimentares Supervisor of Daniela Felício	Biomedical Sciences (Degree) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/03/01 - 2018/07/05	Associação entre Osteoartrose, Obesidade e Metabolismo do ferro, um estudo exploratório Co-supervisor	Biomedical Sciences (Degree) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2017/02/01 - 2017/07/15	Abordagem morfológica e molecular ao estudo de factores de desenvolvimento da osteoporose Co-supervisor of Xavier Guerreiro	Biomedical Sciences (Degree) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2016/02/01 - 2016/07/15	Caracterização da expressão do transportador de Zinco ZIP14 no peixe-zebra (Danio rerio) e sua validação para estudos biomédicos Co-supervisor of Beatriz Estremores	Biomedical Sciences (Degree) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2015/02/01 - 2015/07/10	Caracterização de uma cultura de osteoblastos primária isolada a partir de ratinhos Hfe KO. Impacto do excesso de ferro na mineralização Co-supervisor of Gabriela Carrasqueira	Biomedical sciences (Degree) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2024/09/12 - 2024/09/13	Ectopic calcification: Friend or foe? Annual meeting of the International Network on Ectopic Calcifications (2024/06/01 - 2024/09/13) Meeting (Member of the Organising Committee)	Centro de Ciências do Mar, Portugal
2024/03 - 2024/03	Understanding the pathophysiology of Keutel Syndrome: A path towards cure (2024/03 - 2024/03) Round table (Member of the Organising Committee)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal Centro de Ciências do Mar, Portugal
2023/09/26 - 2024/01/26	IX CLINICAL BIOCHEMISTRY WORKSHOP- LIFESPAN, HEALTH & METABOLIC DISEASES (2024/01/25 - 2024/01/26) Workshop (Member of the Scientific Committee)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2025/01/27	Transcriptome profiling in Spinocerebellar ataxia type 2: a focus on RNA-binding proteins President of the jury	Lorenzo Macedo Correa Mirapalheta (Master) Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas, Portugal
2025/01/21	Gene therapy for Cockayne syndrome: in vivo studies President of the jury	Adriana Afonso Vaz (Master) Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/12/13	Exploring Angiogenesis and Cardiomyocyte Differentiation in Left Ventricular Noncompaction using patient derived hiPSC President of the jury	Sara Martins do Carmo (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/07/18	Peixe-zebra como modelo no estudo da Acondroplasia (Thesis) Main arguer	Marisa Alves Ferreira (Other) Universidade do Algarve, Portugal Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/01/17	MONITORIZAÇÃO DE PIGMENTOS NA PRODUÇÃO DE MICROALGAS President of the jury	Nicole Marques Costa (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024/01/12	Modelling left ventricular noncompaction cardiomyopathy in cardioids President of the jury	Cátia Dias Correia (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/11/22	Caracterização da expressão do gene ZFP36L1 associado a mecanismos de patogénese da osteoartrose e osteoporose Supervisor	Mafalda Guela Lázaro (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/07/25	Metals, Oxidative Stress and its role in Parkinson's Disease (Thesis) Main arguer	Richard Vasco Santos (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/07/11	O papel das proteínas ligantes de RNA no importe vesicular do mRNA da ataxina-2 (Thesis) Main arguer	Érica Filipa Almeida Silva (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/07/11	Estabelecimento de modelos celulares de Síndrome de Down: uma nova ferramenta para o estudo do desenvolvimento neuronal (Thesis) Main arguer	Igor Vairinho Ventura (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/07/05	CITED2 como potencial alvo terapêutico em glioblastoma (Thesis) Main arguer	Margarida Isabel Custódio Pereira Guerreiro (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/07	Estudo da localização subcelular de CITED4 em glioblastoma: Será CITED4 sequestrado para grãnulos de stress? (Thesis) Main arguer	Mariana Silva de Oliveira Duarte (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/20	Traumas, periostite e osteomalacia na coleção de esqueletos identificados de Évora (Thesis) Main arguer	Marina Isabel Lourenço Reis (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/19	Doença de McArdle: Revisão Literária e casos de estudo (Thesis) Main arguer	Ana Francisca Dias (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/19	Sifílis congénita: Doença antiga, nova tecnologia (Thesis) Main arguer	Mariana Pires Aleixo (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/19	Análise funcional de um elemento 3'-UTR do gene DeltaC na somitogénese de peixe-zebra (Thesis) Main arguer	Thalita Carolina Carvalho (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/18	A contribuição da antropologia forense em contexto de terrorismo- Revisão Bibliográfica (Thesis) Main arguer	Tânia Vaz (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/12/13	Characterization of 5’ and 3’ UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism Supervisor	Joel Mourato da Silva (Master) Universidade do Algarve Faculdade de Ciencias e Tecnologia, Portugal
2021/07/30	Utilização de células estaminais pluriputotentes induzidas como modelo celular de miocardiopatia não compactada (Thesis) Main arguer	Inês Clara Dórdio (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/07/23	Estudo da expressão e localização subcellular de CITED2 e CITED4 em linhas celulares de cancro mantidas em diferentes condições de disponibilidade de ferro (Thesis) Main arguer	Inês Torradinhas Militão (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/07/23	Estudo sobre potenciais efeitos anti-cancerígenos de polioxovanadatos no melanoma (Thesis) Main arguer	João Pedro Soares Gonçalves (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/07/22	Silenciamento da forma mutada do gene ATXN2 como potencial estratégia terapêutica para a ataxia espinocerebelosa tipo 2 (Thesis) Main arguer	Catarina Barbosa (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/07/07	Analise da expressão da proteína MOB4 ao longo do ciclo celular (Thesis) Main arguer	Daniela Pais (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/10/20	Mediadores do metabolismo corporal e seu papel no encelhecimento (Thesis) Main arguer	Betsabé de La Salete Farias Comparada Martins Viera (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/07/27	Beta-oxidação mitocondrial dos ácidos gordos e deficiência nas desidrogenases dos Acil-CoA: Diagnóstico laboratorial e abordagens terapêuticas (Thesis) Main arguer	Mariana Henriques Policarpo (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/07/24	Modulação dos membros da família Tribbles através da hipoxia (Thesis) Main arguer	Miriam de Fátima Luís Varela (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/07/06	Alvos terapêuticos para a ataxia espinocerebelosa do tipo 2: o que foi feito? (Thesis) Main arguer	Myroslava Kozak (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/07	Proliferation study during ear regeneration in Acomys cahirinus (Thesis) Main arguer	Roland Valentin Bumbue (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal

Committee member

	Activity description Role	Institution / Organization
2023/09/01 - Current	Member of the master's management committee- Master in Biomedical Sciences -Disease mechanisms Member	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023/09/01 - Current	Histology	Biomedical Sciences (Licenciatura)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/09/01 - Current	Aplications in Histology	Biomedical Sciences (Licenciatura)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/09/01 - Current	Metabolic Diseases	Biomedical Sciences (Licenciatura)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020/09/15 - Current	Laboratories in Biomedicine	Master in Biomedical Sciences-Disease mechanism (Mestrado)	Universidade do Algarve - Campus de Gambelas, Portugal Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2019/02/01 - Current	Cell differentiation and microenvironments	Oncobiology (Mestrado)	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/09/15 - Current	Cell Biology	Biomedical Sciences	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/09/15 - 2020/09/01	Molecular and Celular Biology Techniques	Biomedical Sciences Master (Mestrado)	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Journal scientific committee

	Journal title (ISSN)	Publisher
2023/10/03 - Current	Frontiers in Cell and Developmental Biology (2296-634X)	Frontiers
2023/02/02 - Current	Aquatic Toxicology (ISSN: 0166-445X)	Elsevier

Distinctions

Award

2021	Prémio Boas práticas da Universidade do Algarve Universidade do Algarve, Portugal
2019	Grisp prize for best oral communication Universidade do Porto -11th Symposium in Metabolism, "Ageing & Metabolism" (2019), Portugal
2018	Best Poster-Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB), 5th Conference Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB), 5th Conference, Portugal