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Identification

Personal identification

Full name
Alexandra Melo

Citation names

  • Melo, Alexandra A.

Author identifiers

Ciência ID
F511-3BD5-EE7A

Email addresses

  • xana.almeidamelo@gmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine - Toxicology

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Portuguese (Mother tongue)
Education
Degree Classification
2025/02/01 - 2028
Ongoing
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2024/04/21 - 2024/04/21
Concluded
 Introduction to Laboratory Safety (Outros)
Lab Safety Workspace, United States
 100%
2024/04/21 - 2024/04/21
Concluded
 Introduction to Biological Safety Level 2 Training (Outros)
Lab Safety Workspace, United States
 100%
2021/09/06 - 2023/10/24
Concluded
 Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
""The Immunomodulatory Effect of the Roots of Withania Somnifera Encapsulated Into Beta - Glucan Particles"" (THESIS/DISSERTATION)
 17/20
2018/09/10 - 2021/06/25
Concluded
 Farmácia Biomédica (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 14/20
2021/03/14
Concluded
 ICH GOOD CLINICAL PRACTICE E6 (R2) (Outros)
The Global Health Network, United Kingdom
 100%
2020/11/16 - 2020/12/03
Concluded
 Excel Course (Outros)
Universidade de Coimbra Faculdade de Farmácia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2024/04/15 - Current Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/05/30 - 2022/07/30 Research Trainee (Research) Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/02/03 - 2022/02/28 Research Trainee (Research) Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal
CLPP Vaccines Network, Portugal
2021 - 2022 Research Trainee (Research) Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020 - 2021 Collaborator in the Student Support Office Department Núcleo de Estudantes de Farmácia da Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2024/04/15 - Current CiNTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
IT137-24-77
Research Fellow
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/08/29 - 2022/09/28 Using dendritic cell reprogramming to identify new immunotherapy targets
IT137-22-062
Scientific Initiation Fellow
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Borges, Olga; Colaço, M.; Panão Costa, João. "The immunomodulatory effect of the roots of Withania somnifera encapsulated with ß-glucan nanoparticles". Paper presented in Annual Meeting of Doctoral Students - PharmaPh Day, 2024.
  2. Miranda, CO; Rita Perfeito; Sónia P. Duarte; Paulo, Cristiana; RODRIGUES, M. T.; Gaspar, Laetitia S; Pereira, Dina; et al. "Comparative analysis of transfection kits for linear, self-amplifying, and circular RNA". Paper presented in ESGCT 31st Annual Congress, 2024.
  3. Pereira, Dina; Valdeira, A. S. C.; Santos Silva, Francisca; Gaspar, Laetitia S; De Luca, Pasqualino; Perdigão, PRL; Lopes, Sara M. ; et al. "A comparative analysis of commercial kits for enhanced circular mRNA production: yield, profile, and in vitro assessment". Paper presented in ESGCT 31st Annual Congress, 2024.
  4. Gaspar, Laetitia S; Marques, Bruno; De Luca, Pasqualino; Pereira, Dina; Perdigão, PRL; Lopes, Sara M. ; Rita Perfeito; et al. "Cost-Effective Optimization of Self-Amplifying mRNA Production: Comparative Analysis of Commercial Kits and In Vitro Transcription Conditions". Paper presented in 12th mRNA Health Conference, 2024.
  5. Pereira, Dina; Valdeira, A. S. C.; De Luca, Pasqualino; Gaspar, Laetitia S; Lopes, Sara M. ; Perdigão, PRL; Santos Silva, Francisca; et al. "Enhancing circular mRNA yield through in vitro transcription optimization". 2024.
  6. Sónia P. Duarte; Rita Perfeito; Miranda, CO; RODRIGUES, M. T.; Paulo, Cristiana; Pereira, Dina; De Luca, Pasqualino; et al. "Functional assays to optimize transfection efficiency for linear, circular and self-amplifying mRNA". Paper presented in 12th mRNA Health Conference, 2024.
  7. De Luca, Pasqualino; Perdigão, PRL; Gaspar, Laetitia S; Pereira, Dina; Marques, Bruno; Lopes, Sara M. ; Melo, Alexandra A.; et al. "Maximizing mRNA vaccine production by optimizing in vitro transcription processes". Paper presented in 12th mRNA Health Conference, 2024.
  8. Gaspar, Laetitia S; Marques, Bruno; Pereira, Dina; De Luca, Pasqualino; Perdigão, PRL; Lopes, Sara M. ; Rita Perfeito; et al. "Maximizing Yield and Functionality in saRNA Production: A Comparative Study of Commercial Kits and In Vitro Transcription Conditions". Paper presented in ESGCT 31st Annual Congress, 2024.
  9. De Luca, Pasqualino; Lopes, Sara M. ; Pereira, Dina; Gaspar, Laetitia S; Marques, Bruno; Perdigão, PRL; Melo, Alexandra A.; et al. "Optimizing in vitro transcription methods for enhanced mRNA-based therapeutics". Paper presented in ESGCT 31st Annual Congress, 2024.
  10. Panão Costa, J.; Colaço, M; Félix, P.; Melo, Alexandra A.; Lebre, F.; Cruz, M. T.; Alfaro-Moreno, E.; Moreira, J. N.; Borges, O.. "ß-glucan polymeric microparticles: innovating cancer immunotherapy through targeted antigen delivery.". Paper presented in 6th ASPIC International Congress, 2024.
  11. Melo, Alexandra A.; Colaço, Mariana; Panão Costa, João; Borges, Olga. "The Immunomodulatory Effect of the Roots of Withania Somnifera Encapsulated Into ß - Glucan Particles". Paper presented in X Iberoamerican Congress of Pharmaceutical Sciences, 2023.
Journal article
  1. Panão Costa, João; Colaço, Mariana; Félix, Paulo; Melo, Alexandra A.; Gomes, Célia; Borges, Olga. "Dual Oral Vaccine Formulation for Chronic Hepatitis B: Leveraging Glucan Particles to Target the Liver and Enhanced Cellular Immune Response". (2025):
    Submitted
  2. Félix, Paulo; Melo, Alexandra A.; Panão Costa, João; Colaço, Mariana; Pereira, Dina; Núñez, Jisette; Pereira de Almeida, Luis ; Borges, Olga. Corresponding author: Borges, Olga. "Exploring TLR agonists as adjuvants for COVID-19 oral vaccines". Vaccine 53 (2025): https://doi.org/10.1016/j.vaccine.2025.127078.
    Published
Activities

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/11/22 - Current Participation at Annual Meeting of Doctoral Students - PharmaPh Day
Congress
 Annual Meeting of Doctoral Students - PharmaPh Day
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/10/26 - 2023/10/28 Participation at X Iberoamerican Congress of Pharmaceutical Sciences
Congress
 X Iberoamerican Congress of Pharmaceutical Sciences
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/10/18 - 2023/10/22 Participation at iMed Conference 15.0
Congress
 iMed Conference 15.0
Universidade Nova de Lisboa Medical School, Portugal
2021/04/15 - 2021/04/15 Mendeley online workshop: bibliographic reference manager
Workshop
 Mendely: bibliographic reference manager
Universidade de Coimbra Biblioteca Geral, Portugal
2021/03/21 - 2021/03/21 Participation at Training in Leadership and Team Management Training in Leadership and Team Management
Núcleo de Estudantes de Farmácia da Universidade de Coimbra, Portugal
2021/03/17 - 2021/03/18 Participation at VIII Dermopharmacy and Cosmetics Training - Hair Care
Congress
 VIII Dermopharmacy and Cosmetics Training - Hair Care
Núcleo de Estudantes de Farmácia da Universidade de Coimbra, Portugal
2019/11/29 - 2019/11/29 Participation at VII NEF/AAC Dermopharmacy and Cosmetics Training: Cosmetics in the 21st Century
Congress
 VII NEF/AAC Dermopharmacy and Cosmetics Training: Cosmetics in the 21st Century
Núcleo de Estudantes de Farmácia da Universidade de Coimbra, Portugal