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Maria J. S. A. Silva obtained her MSc in Pharmaceutical Sciences in 2016 from the Faculty of Pharmacy, University of Lisbon (FFUL). During her Master degree, she joined Dr. Pedro Gois group to work on Chemical Biology and later, she did a 3-month internship at Sapienza, Università di Roma in Medicinal Chemistry thanks to the Erasmus Programme. In May 2021, she received her PhD degree in Pharmacy with the highest grade, distinction and honors at FFUL. Her PhD studies focused on novel site-selective bioconjugation strategies and their application to targeted photodynamic therapy in a joint project under the supervision of Dr. Pedro Gois and Prof. Dr. Gilles Gasser from Chimie ParisTech. Last year, she joined the group of Prof. Tanja Weil as a postdoctoral researcher at Max Planck Institute for Polymer Research in Mainz, aiming to design new biotherapeutics to address metastatic niches and study the tumor microenvironment by MS-imaging. So far, she has 8 publications in journals of high impact factor, 4 of them as first author, including one Angew. Chem. Int. Ed. Also recently, she published her first paper as co-corresponding author.
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Identification

Personal identification

Full name
Maria José Santos Alves Silva

Citation names

  • Silva, Maria José dos Santos Alves da

Author identifiers

Ciência ID
F41A-9D1E-748D
ORCID iD
0000-0003-4178-1942
Researcher Id
E-8208-2017
Scopus Author Id
57198412711

Knowledge fields

  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Italian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2018/01/01 - 2022/05/19
Concluded
 PhD in Pharmacy (Doutoramento)
Major in Pharmaceutical and Therapeutic Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"New Bioconjugation Strategies for Selective Cysteine Functionalization" (THESIS/DISSERTATION)
 Distinction and Honors
2011 - 2016
Concluded
 Integrated Masters in Pharmaceutical Sciences (Mestrado)
Universidade de Lisboa, Portugal

Università degli Studi di Roma La Sapienza, Italy
"Trypanothione Reductase: design of a potential new class of inhibitors" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2022/10/01 - Current Postdoc (Research) Max-Planck-Institut für Polymerforschung, Germany
Max-Planck-Institut für Polymerforschung, Germany
2022/07/01 - 2022/09/30 Postdoc (Research) Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/02 - 2016/04 Research Trainee (Research) Università degli Studi di Roma La Sapienza, Italy

Others

Category
Host institution 		Employer
2018/01/01 - 2022/05/19 Estudante Doutoramento Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/05 - 2017/12 Research scholarship Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2022/07/01 - 2022/09/30 1Pot2Cat: one-pot bimetallic catalyzed synthesis of challenging heterocycles
PTDC/QUI-QOR/0712/2020
Post-doc
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01/01 - 2022/05/19 New Bioconjugation Strategies for Selective Cysteine Functionalization
SFRH/BD/132710/2017
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal

Chimie ParisTech - PSL, L’École Nationale Supérieur de Chimie de Paris, France
Fundação para a Ciência e a Tecnologia
Concluded
2017/05/02 - 2017/12/31 BLINK: NOVAS ESTRATÉGIAS DE BIOCONJUGAÇÃO E TRANSPORTE DIRIGIDO DE ÁCIDOS BORÓNICOS
PTDC/QEQ-QOR/1434/2014
Master Student Fellow
Outputs

Publications

Conference poster
  1. Silva, Maria José dos Santos Alves da. Corresponding author: Silva, Maria José dos Santos Alves da. "Bifunctional NHS-Activated Acrylamides for Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins". Paper presented in 11th iMed.ULisboa Meeting, Lisbon, PT, 2021.
  2. Maria J. S. A. Silva. Corresponding author: Maria J. S. A. Silva. "Competitive functionalization of N-terminal amino acids via iminoboronate intermediates with B-N bond stabilization". Paper presented in 2nd PSL Chemical Biology Symposium, Paris, FR, 2019.
  3. Silva, Maria José dos Santos Alves da. "Competitive functionalization of N-terminal amino acids via iminoboronate intermediates with B-N bond stabilization". Paper presented in XXII Encontro Nacional de Química Orgânica / V Encontro Nacional de Química Terapêutica, Coimbra, PT, 2018.
  4. Silva, Maria José dos Santos Alves da. "Competitive functionalization of N-terminal amino acids via iminoboronate intermediates with B-N bond stabilization". Paper presented in XXV Encontro Nacional da Sociedade Portuguesa de Química, Lisboa, PT, 2017.
Journal article
  1. Maria J. S. A. Silva; Robin Vinck; Youchao Wang; Bruno Saubaméa; Mickaël Tharaud; Elena Dominguez-Jurado; Johannes Karges; Pedro M. P. Gois; Gilles Gasser. "Towards Selective Delivery of a Ruthenium(II) Polypyridyl Complex-Containing Bombesin Conjugate into Cancer Cells". ChemBioChem (2023): https://doi.org/10.1002/cbic.202200647.
    10.1002/cbic.202200647
  2. João Macara; Catarina Caldeira; José Cunha; Jaime A. S. Coelho; Maria J. S. A. Silva; Konrad Krämer; Christoph W. Grathwol; Stefan Bräse; M. Manuel B. Marques. "Practical synthesis and biological screening of sulfonyl hydrazides". Organic & Biomolecular Chemistry (2023): https://doi.org/10.1039/D2OB02160A.
    10.1039/D2OB02160A
  3. Maria J. S. A. Silva; Rafaela A. N. Cavadas; Hélio Faustino; Luís F. Veiros; Pedro M. P. Gois. "Front Cover: Interactive Bioconjugation at N -Terminal Cysteines by Using O -Salicylaldehyde Esters towards Dual Site-Selective Functionalization (Chem. Eur. J. 67/2022)". Chemistry – A European Journal (2022): https://doi.org/10.1002/chem.202203566.
    10.1002/chem.202203566
  4. Maria J. S. A. Silva; Rafaela A. N. Cavadas; Hélio Faustino; Luís F. Veiros; Pedro M. P. Gois. "Interactive Bioconjugation at N -Terminal Cysteines by Using O -Salicylaldehyde Esters towards Dual Site-Selective Functionalization". Chemistry – A European Journal (2022): https://doi.org/10.1002/chem.202202377.
    10.1002/chem.202202377
  5. Mariama Djaló; Maria J. S. A. Silva; Hélio Faustino; Sandra N. Pinto; Ricardo Mendonça; Pedro M. P. Gois. "Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues". Chemical Communications (2022): https://doi.org/10.1039/D2CC02204D.
    10.1039/D2CC02204D
  6. Maria J. S. A. Silva; Pedro M. P. Gois; Gilles Gasser. "Unveiling the Potential of Transition Metal Complexes for Medicine: Translational in Situ Activation of Metal-Based Drugs from Bench to in Vivo Applications". ChemBioChem (2021): https://doi.org/10.1002/cbic.202100015.
    10.1002/cbic.202100015
  7. Maria J. S. A. Silva; Hélio Faustino; Jaime A. S. Coelho; Maria V. Pinto; Adelaide Fernandes; Ismael Compañón; Francisco Corzana; Gilles Gasser; Pedro M. P. Gois. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie International Edition 60 19 (2021): 10850-10857. https://doi.org/10.1002/anie.202016936.
    10.1002/anie.202016936
  8. Lujuan Xu; Maria J. S. A. Silva; Pedro M. P. Gois; Seah Ling Kuan; Tanja Weil. "Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents". Chemical Science (2021): https://doi.org/10.1039/D1SC03250J.
    10.1039/D1SC03250J
  9. Faustino, Hélio; Silva, Maria J. S. A.; Veiros, Luís F.; Bernardes, Gonçalo J. L.; Gois, Pedro M. P.. "Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation". Chem. Sci. 7 8 (2016): 5052-5058.
    Published • 10.1039/C6SC01520D
  10. Faustino, H.; Silva, M.J.S.A.; Veiros, L.F.; Bernardes, G.J.L.; Gois, P.M.P.. "Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation". Chemical Science 7 8 (2016): 5052-5058. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978985571&partnerID=MN8TOARS.
    10.1039/c6sc01520d
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022 Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides 5th CQUL meeting – “Forging Bonds”
University of Lisbon (Portugal)
2022 New Bioconjugation Strategies for Selective Cysteine Functionalization PhD students seminars, iMed.ULisboa Postgraduate Students Commission, Lisbon, PT
iMed.ULisboa Postgraduate Students Commission (Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - 2022 New library of Boronic acid-derived salicylidenehydrazone complex (BASHY)
Co-supervisor of Ana Catarina Santos
 Project-Based Learning II (7th semester in Integrated Masters in Pharmaceutical Sciences) (Scientific initiation)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2021 Dual modification of peptides with bifunctional reagents
Co-supervisor of José Miguel Apolónia da Mata
 Project-based Learning (6th semester in Biological Engineering, at Instituto Superior Técnico, Lisboa (Scientific initiation)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Boronic acids for Cysteine modification
Co-supervisor of Ana Patrícia Chaves
 Project-Based Learning III (8th semester in Integrated Masters in Pharmaceutical Sciences) (Scientific initiation)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/07/01 - 2017/07/19 Organizing Committee of XXV EN-SPQ, XXV Portuguese Society of Chemistry National Meeting, Faculty of Pharmacy, University of Lisbon Portugal (2017/07/16 - 2017/07/19)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Química, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - Current MPIP Poster Day 2022
Evaluator
 Max-Planck-Institut für Polymerforschung, Germany
Distinctions

Other distinction

2016 Erasmus+ Programme
Agência Nacional Portuguesa ERASMUS+ Educação e Formação, Portugal