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Sara Raquel Martins Neves. Concluiu Engenharia Biomédica pela Universidade de Coimbra em 2017. É da Universidade de Coimbra. Publicou 6 artigos em revistas especializadas e 7 trabalhos em actas de eventos. Participou em 7 eventos no estrangeiro e 12 em Portugal. Orientou 1 trabalho de conclusão de curso de bach./licenciatura e 1 trabalho de iniciação científica na área de Ciências da Saúde. Recebeu 4 prémios e/ou homenagens. Actua na área de Ciências Médicas com ênfase em Ciências da Saúde. Nas suas actividades profissionais interagiu com 35 colaboradores em co-autorias de trabalhos científicos. No seu curriculum DeGóis os termos mais frequentes na contextualização da produção científica e tecnológica são: cancer stem cells, osteosarcoma, [18F]FDG uptake, chemotherapy, radioresistance, cell cycle, animal model, osteosarcoma clinical samples e radiotherapy.
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Identification

Personal identification

Full name
Sara R Martins-Neves

Citation names

  • Martins-Neves, SR

Author identifiers

Ciência ID
F412-9466-ABA2
ORCID iD
0000-0002-9370-5899

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010 - 2017
Concluded
 Engenharia Biomédica (Doutoramento)
Universidade de Coimbra, Portugal
"Cancer Stem-like Cells in Human Osteosarcoma: Tracking Stemness to target Chemoresistance" (THESIS/DISSERTATION)
 Distinção e Louvor por Unanimi
2014 - 2014
Concluded
 Laboratory Animal Science (FELASA category C) (Curso médio)
Universidade do Porto, Portugal
2013 - 2013
Concluded
 MGC PhD Course - Signal transduction and diseases (Curso médio)
Universiteit Leiden, Netherlands
2013 - 2013
Concluded
 Genome Maintenance & Cancer (Curso médio)
Universiteit Leiden, Netherlands
2012 - 2012
Concluded
 MGC PhD Course - Technology Facilities (Curso médio)
Universiteit Leiden, Netherlands
2011 - 2011
Concluded
 Animal Models for Physiology and Disease (Curso médio)
Universidade de Coimbra, Portugal
2011 - 2011
Concluded
 Cancer and Oncobiology (Curso médio)
Universidade de Coimbra, Portugal
2011 - 2011
Concluded
 Immunity and Infection (Curso médio)
Universidade de Coimbra, Portugal
2011 - 2011
Concluded
 Recent Advances in Clinical Management of Cancer – From Bench-to-Bedside (Curso médio)
Universidade de Coimbra, Portugal
2011 - 2011
Concluded
 Biomedical Imaging (Curso médio)
Universidade de Coimbra, Portugal
2010 - 2010
Concluded
 Cell Regulation and Signalling (Curso médio)
Universidade de Coimbra, Portugal
2010 - 2010
Concluded
 From Genotype to Phenotype (Curso médio)
Universidade de Coimbra, Portugal
2009 - 2010
Concluded
 English Language Course (Curso médio)
Universidade de Coimbra, Portugal
2005 - 2010
Concluded
 Engenharia Biomédica (Mestrado)
Universidade de Coimbra, Portugal
"Identification of Cancer Stem-like Cells in Osteosarcoma: Implications in Radioresistance (Final Mark 20/20)" (THESIS/DISSERTATION)
 15
2010
Concluded
 Engenharia Biomédica (Doutoramento)
Major in Sem especialidade
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Cancer Stem Cells in Human Osteosarcoma: Tracking Stemness to Target Chemoresistance" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2008 - 2009
Concluded
 English Language Course (Curso médio)
Universidade de Coimbra, Portugal
Affiliation

Science

Category
Host institution 		Employer
2010/09 - 2017/05 Research Assistant (Research) Universidade de Coimbra, Portugal
2015/04 - 2015/09 Research Assistant (Research) CIMAGO - Faculty of Medicine, University of Coimbra, Portugal
2015/04 - 2015/09 Research Assistant (Research) Núcleo Regional do Centro da Liga Portuguesa contra o Cancro, Portugal
2011/04 - 2015/03 Research Assistant (Research) Fundação para a Ciência e a Tecnologia, Portugal
2011/10 - 2013/12 Research Assistant (Research) Universiteit Leiden, Netherlands
Outputs

Publications

Conference abstract
  1. Martins-Neves, Sara. "Cancer stem cell populations in osteosarcoma: implications for [18F]FDG uptake and response to therapy". 2010.
    10.1007/s00259-010-1557-3
  2. S. R. M. Neves; A. O. G. Lopes; A. J. Abrunhosa; P. C. P. S. Simões; A. A. Paiva; M. Botelho; C. M. F. Gomes. "Cancer stem cell populations in osteosarcoma: implications for [18F]FDG uptake and response to therapy". Paper presented in Annual Congress of the European Association of Nuclear Medicine, Vienna, 2010.
    Published
  3. C. M. F. Gomes; S. R. M. Neves; A. O. G. Lopes; A. do Carmo; A. J. Abrunhosa; M. Botelho. "Assessing metabolic activity of cancer stem cells during differentiation with [18F]FDG". Paper presented in Annual Congress of the European Association of Nuclear Medicine, Vienna, Austria, 2010.
    Published
  4. C. M. F. Gomes; S. R. M. Neves; A. O. G. Lopes; A. J. Abrunhosa; P. C. P. S. Simões; A. A. Paiva; M. Botelho. "Role of Cancer Stem Cells in [18F]FDG Uptake and Therapy Response in Osteosarcoma". Paper presented in 2010 World Molecular Imaging Congress, Kyoto, 2010.
    Published
  5. A. O. G. Lopes; S. R. M. Neves; A. do Carmo; A. A. Paiva; M. Botelho; C. M. F. Gomes. "Identification of Cancer Stem Cells in Osteosarcoma and their implications in response to Chemotherapy". Paper presented in 16th International Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
    Published
  6. Neves, Sara Raquel Martins; A. O. G. Lopes; A. do Carmo; A. J. Abrunhosa; P. C. P. S. Simões; A. A. Paiva; M. Botelho; C. M. F. Gomes. "Osteosarcoma contains a subpopulation of Cancer Stem-like Cells that are highly resistant to Radiotherapy". Paper presented in 16th Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
    Published
Conference paper
  1. Martins-Neves, SR; Brendy E. van den Akker; Willem E. Corver; Anne-Marie Cleton-Jansen; C. M. F. Gomes. "Identifying Tumor-initiating Cells in Human Osteosarcoma Cell Lines – the Function Matters". Paper presented in 22nd Biennial Congress of the European Association for Cancer Research, Barcelona, 2012.
    Published • 10.1016/S0959-8049(12)71066-3
  2. Neves, Sara Raquel Martins; Gomes, Celia Maria Freitas. "Identification of cancer stem-like cells in osteosarcoma: Implications in radioresistance". Paper presented in 2011 1st Portuguese Meeting in Bioengineering ¿ The Challenge of the XXI Century (ENBENG), Lisbon, Portugal, 2011.
    Published • 10.1109/ENBENG.2011.6026095
  3. Martins-Neves, Sara. "Assessing metabolic activity of cancer stem cells during differentiation with [18F]FDG". 2010.
    10.1007/s00259-010-1559-1
Journal article
  1. Martins-Neves SR; Cleton-Jansen AM; Gomes CMF. "Therapy-induced enrichment of cancer stem-like cells in solid human tumors: Where do we stand?". Pharmacological research (2018): http://europepmc.org/abstract/med/30316903.
    10.1016/j.phrs.2018.10.011
  2. Paiva-Oliveira, Daniela I.; Martins-Neves, Sara R; Abrunhosa, Antero J; Fontes-Ribeiro, Carlos; Gomes, Célia M. F.. "Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells". Cancer Chemotherapy and Pharmacology -- (2017): 00-00. https://link.springer.com/article/10.1007%2Fs00280-017-3467-6.
    Published • 10.1007/s00280-017-3467-6
  3. Martins-Neves, Sara R; Paiva-Oliveira, Daniela I.; Fontes-Ribeiro, Carlos; Bovée, Judith V.M.G.; Cleton-Jansen, Anne-Marie; Gomes, Célia.M. F.. "IWR-1, a tankyrase inhibitor, attenuates WNT/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft". Cancer Letters 414 1 (2017): 1-15. http://www.cancerletters.info/article/S0304-3835(17)30698-5/fulltext.
    Published • 10.1016/j.canlet.2017.11.004
  4. Martins-Neves, Sara R; Paiva-Oliveira, Daniela I.; Wijers-Koster, Pauline M.; Abrunhosa, Antero J; Fontes-Ribeiro, Carlos; Bovée, Judith V.M.G.; Cleton-Jansen, Anne-Marie; Gomes, Célia M.F.. "Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/ß-catenin signaling". Cancer Letters 370 2 (2016): 286-295.
    Published • 10.1016/j.canlet.2015.11.013
  5. Martins-Neves, Sara R; Corver, Willem E.; Paiva-Oliveira, Daniela I.; van den Akker, Brendy E. W. M.; Briaire-de-Bruijn, Inge H.; Bovée, Judith V. M. G.; Gomes, Célia M. F.; Cleton-Jansen, Anne-Marie. "Osteosarcoma Stem Cells Have Active Wnt/ß-catenin and Overexpress SOX2 and KLF4". Journal of Cellular Physiology 231 4 (2016): 876-886.
    Published • 10.1002/jcp.25179
  6. Gonçalves, Cláudia; Martins-Neves, Sara R; Paiva-Oliveira, Daniela; Oliveira, Vitor E.B.; Fontes-Ribeiro, Carlos; Gomes, Célia M.F.. "Sensitizing osteosarcoma stem cells to doxorubicin-induced apoptosis through retention of doxorubicin and modulation of apoptotic-related proteins". Life Sciences 130 - (2015): 47-56.
    Published • 10.1016/j.lfs.2015.03.009
  7. Martins-Neves, Sara R; Lopes, Aurio O; Carmo, Analia DO; Paiva, Artur A; Simoes, Paulo C; Abrunhosa, Antero J; Gomes, Celia M. "Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line". BMC Cancer 12 1 (2012): 139-139.
    Published • 10.1186/1471-2407-12-139
Thesis / Dissertation
  1. Neves, Sara Raquel Martins. "Cancer Stem Cells in Human Osteosarcoma: Tracking Stemness to Target Chemoresistance". PhD, 2017. http://hdl.handle.net/10316/32345.
  2. Neves, Sara Raquel Martins.. "Identification of cancer stem-like cells in osteosarcoma: implications in radioresistance". Master, 2010. http://hdl.handle.net/10316/13798.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - 2015 Wnt/ß-catenin signaling in osteosarcoma stem cells
Co-supervisor
 Mestrado em Investigação Biomédica (Scientific initiation)
Universidade de Coimbra, Portugal
2014 - 2014 Resistência das células parentais e das células estaminais cancerígenas de osteossarcoma aos tratamentos de quimioterapia com doxorrubicina
Co-supervisor
 Bioquímica (Degree)
Universidade de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2015 - 2015 Osteosarcoma stem cells are functional heterogeneous populations and have distinct genetic profiles
Congress
 Atualizações em Oncologia 2015, 29ª Reunião - 4º Congresso do CIMAGO
CIMAGO, Portugal
2015 - 2015 Low doses of chemotherapy induce the enrichment of cancer stem-like cells in osteosarcoma
Meeting
 XXIII Porto Cancer Meeting - Stem Cells and Cancer
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014 - 2014 Wnt/ß-catenin signaling is active in osteosarcoma stem cells
Congress
 Atualizações em Oncologia 2014, 28ª Reunião - 3º Congresso do CIMAGO
CIMAGO, Portugal
2014 - 2014 Intrinsic Heterogeneity of Human Osteosarcoma Stem Cells: the Function Matters
Congress
 XVIII Congress of the Portuguese Biochemical Society
Sociedade Portuguesa de Bioquímica, Portugal
2014 - 2014 Selective eradication of osteosarcoma stem cells by targeting Wnt/ß-catenin signalling activity
Congress
 XVIII Congress of the Portuguese Biochemical Society
Sociedade Portuguesa de Bioquímica, Portugal
2014 - 2014 Selective eradication of osteosarcoma stem cells by targeting Wnt/ß-catenin signaling activity
Congress
 1st ASPIC International Congress
Associação Portuguesa de Investigação em Cancro, Portugal
2014 - 2014 Wnt/ß-catenin inhibition selectively eliminates osteosarcoma stem cells by downregulation of stemness networks and induction of apoptotic cell death
Meeting
 VI IBILI Meeting
CNC.IBILI, Portugal
2013 - 2013 Wnt/ß-catenin signaling in osteosarcoma cancer stem cells
Symposium
 MGC meeting 2013
Medisch Genetisch Centrum Zuid-West Nederland, Netherlands
2013 - 2013 Wnt/ß-catenin signalling in osteosarcoma stem cells
Symposium
 3rd Global Cancer Genomics Consortium Symposium - From Oncogenomics To Cancer Care
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2013 - 2013 Wnt/ß-catenin signaling is active in osteosarcoma stem cells
Meeting
 22nd annual meeting of the KWF society for Tumor Cell Biology
KWF Society for Tumor Cell Biology, Netherlands
2013 - 2013 Role of Apoptotic Pathways in Chemoresistance of Osteosarcoma Cancer Stem Cells
Symposium
 Darwinian evolution and clonal heterogeneity in human cancer–biological and clinical implications
Fundação Eng. António de Almeida, European Association for Cancer Research, Portugal
2012 - 2012 Stem-like cells in osteosarcoma: tracking stemness to target resistance
Meeting
 21st annual meeting of the KWF society for Tumor Cell Biology
KWF Society for Tumor Cell Biology, Netherlands
2012 - 2012 Stem-like cells in osteosarcoma: tracking stemness to target resistance
Meeting
 IV IBILI Meeting 2012
¿IBILI - Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Portugal
2012 - 2012 Identifying Tumor-initiating Cells in Human Osteosarcoma Cell Lines – the Function Matters
Congress
 22nd Biennial Congress of the European Association for Cancer Research
European Association for Cancer Research, Spain
2010 - 2010 Role of Cancer Stem Cells in [18F]FDG Uptake and Therapy Response in Osteosarcoma
Congress
 2010 World Molecular Imaging Congress
World Molecular Imaging Society, Japan
2010 - 2010 Cancer stem cell populations in osteosarcoma: implications for [18F]FDG uptake and response to therapy
Congress
 23rd Annual Congress of the European Association of Nuclear Medicine
European Association of Nuclear Medicine, Austria
2010 - 2010 Assessing metabolic activity of cancer stem cells during differentiation with [18F]FDG
Congress
 23rd Annual Congress of the European Association of Nuclear Medicine
European Association of Nuclear Medicine, Austria
2010 - 2010 Osteosarcoma contains a subpopulation of Cancer Stem-like Cells that are highly resistant to radiotherapy
Symposium
 16th Charles Heidelberger Symposium on Cancer Research
2010 - 2010 Identification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapy
Symposium
 16th Charles Heidelberger Symposium on Cancer Research

Association member

Society Organization name Role
2013/09 - Current Faculty of 1000
2014/01 - 2015/12 Portuguese Association for Cancer Research [ASPIC, Associação Portuguesa de Investigação em Cancro, affiliated with the European Association for Cancer Research (EACR)]
2014/01 - 2014/12 Portuguese Biochemical Society [SPB, Sociedade Portuguesa de Bioquímica, affiliated with the Federation of the European Biochemical Societies (FEBS)]
Distinctions

Other distinction

2016 Cover image of the Journal of Cellular Physiology volume 231, issue 4
Journal of Cellular Physiology, Portugal
2015 Recipient of individual scholarship from NRC-LPCC/CIMAGO (Bolsas de Investigação em Oncologia - NRC-LPCC/CIMAGO 2014)
NRC-LPCC/CIMAGO, Portugal
2011 Recipient of individual PhD scholarship grant from Portuguese Foundation for Science and Technology (FCT) – reference SFRH/BD/69603/2010
Portuguese Foundation for Science and Technology, Portugal
2010 Best Poster Award, Instituto Biomédico de Investigação em Luz e Imagem - FMUC - Universidade de Coimbra.
Portuguese Foundation for Science and Technology, Portugal