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Marcos João Mota Leite Machado Mariz is affiliated to the Chemical Process Engineering and Forest Products Research Centre since 2002 and he worked at the Chemical Engineering Department of the Faculty of Science and technology of the University of Coimbra, where the reserach center is located, from 2018 to 2021, with a research contract from a FCT funded project related to its PhD area. He completed the PhD on Chemical Engineering in 2018 at the Faculty of Sciences and Technology of the University of Coimbra. He obtained his Master degree in Vision Sciences in 2000 at the Faculty of Medicine of the University of Coimbra. He completed is graduation in Biochemistry in 1995 at the Faculty of Sciences and Technology of the University of Coimbra . Marcos is co-founder and CEO of INEYE PHARMA, Ltd, a start-up spined-off from the University of Coimbra in 2017 with the purpose to delivery a market product based on the proprietary technology developed during his PhD research - ineye, the registered trademark for an ocular insert capable of prollonged and controlled release of small drugs, biomolecules and large polymers. More recently he his also co-founder and CEO of TIMEUP, Ltd, another start-up spined-off from the University of Coimbra in 2023 with the purpose of further develop a diagnostic device to reduce urinary infections. During his 15 years at Bluepharma, a drug product manufacturer he participated in a lipossome-based technology project and was head of analytical development from 2008 to 2017. From 1995 to 2000 we was affiliated to the Biomedical Institute for Research on Light and Image (former iCBR) where he developed his Master research with a JNICT (former FCT) grant. He published 2 articles in scientifc journals and he is the 1st inventor on a Portuguese patent granted in 2018. He filed an internationatiol patent application. He received 6 national and international entrepreneurship awards related to medical technology. He supervised several MSc dissertations and undergraduate research work. At present, Marcos working areas are Medicinal and Health Sciences, namely Medicinal Biotechnology, and Engineering and Technlogy Sciences, namely Chemical Engineering and Materials Engineering. In his curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: Polymers; Biomaterials; Drug delivery systems; Ocular diseases.
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Identification

Personal identification

Full name
Marcos João Mota Leite Machado Mariz

Citation names

  • M J Mariz
  • M Mariz

Author identifiers

Ciência ID
F310-D5ED-6BDC

Email addresses

  • mmariz@eq.uc.pt (Professional)

Addresses

  • Universidade de Coimbra, Centro de Inv. em Eng. dos Processos Químicos e dos Produtos da Floresta. Departamento de Engenharia Química, Rua Sílvio Lima, Polo II, 3030-790, Coimbra, Coimbra, Portugal (Professional)
  • INEYE PHARMA, Lda IPN - Incubadora Rua Pedro Nunes, 3030-199, Coimbra, Coimbra, Portugal (Professional)
  • TIMEUP - IPN Incubadora, Rua Pedro Nunes, 3030-199, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Engineering and Technology - Chemical Engineering
  • Engineering and Technology - Materials Engineering
  • Engineering and Technology - Medical Engineering
  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Italian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2021/06/07 - 2021/07/09
Concluded
 Wild Card - Deep Dive (Postgraduate Certificate)
Major in Innovation and business modelling on health technologies
European Institute of Innovation & Technology (EIT) - Health, Hungary
2020/11/03 - 2020/11/05
Concluded
 Early Health Technology Assessment (Postgraduate Certificate)
Semmelweis Egyetem, Hungary

European Institute of Innovation & Technology - Health, Hungary
2019/07/01 - 2019/11/30
Attended
 Tech Transfer Leadership in Life Sciences (Postgraduate Certificate)
Major in Gestão da transferência de tecnologia da área da saúde
UPF Barcelona School of Management, Spain
2019/11/15 - 2019/11/16
Concluded
 Regulatory Affairs and Ethics in Clinical Research (Outros)
PMA - Pharmaceutical Medicine Academy, Portugal

Ordem dos Farmaceuticos, Portugal
2018/11/12
Concluded
 Engenharia Química (Doutoramento)
Major in Sem especialidade
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Ocular Drug Delivery Insert Technology: From polymer synthesis to in vitro testing" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
2017 - 2017
Concluded
 Gestão de Projetos (Curso médio)
Winning Scientific Management, Lda, Portugal
2015 - 2016
Concluded
 Empreendedorismo e Desafio Empresarial (Outros)
Universidade de Coimbra, Portugal
2015 - 2015
Concluded
 Granulometria por Difração LASER (Curso médio)
Paralab, S.A., Portugal
2015 - 2015
Concluded
 1º Workshop de Formação - Ensaios de Bioequivalêcnia (Curso médio)
Blueclinical, Portugal
2013 - 2013
Concluded
 Validação de métodos analíticos (Curso médio)
Bluepharma, Indústria Farmacêutica S.A., Portugal
2011 - 2011
Concluded
 Project 2007 - Introdução (Curso médio)
Galileu Centro, Lda, Portugal
2011 - 2011
Concluded
 Introdução à Gestão de Projectos (Curso médio)
Galileu Centro, Lda, Portugal
2011 - 2011
Concluded
 NP-4457 Gestão de IDI (Curso médio)
Socieade Portuguesa de Inovação, Portugal
2010 - 2010
Concluded
 Validação de métodos analíticos (Curso médio)
Bluepharma, Indústria Farmacêutica S.A., Portugal
2010 - 2010
Concluded
 Inglês Técnico - Avançado (Curso médio)
Auchter, Consultoria e Formação, Lda, Portugal
2009 - 2009
Concluded
 Troubleshooting e boas práticas de utilização de equipamentos de HPLC (Curso médio)
Hucoa Erloss - Equipamentos Científicos, Lda, Portugal
2008 - 2008
Concluded
 Liquid handling systems - ISO 8655 (Curso médio)
Eppendorf AG, Germany
2008 - 2008
Concluded
 Preparação de amostra - técnica de SPE (Curso médio)
Hucoa Erloss - Equipamentos Científicos, Lda, Portugal
2008 - 2008
Concluded
 Formação em software Shimadzu HPLC (Curso médio)
Izasa Scientific Portugal WebsiteDirections Save , Portugal
2007 - 2007
Concluded
 Curso básico em software EZChrom Elite (Curso médio)
VWR International, Material de Laboratório, Lda, Portugal
2005 - 2005
Concluded
 Estatística aplicada a laboratórios de análise, I&D e produção industrial (Curso médio)
Sinmetro, Lda, Portugal
2004 - 2004
Concluded
 Utilização avançada de software Empower(R) (Curso médio)
Hucoa Erloss - Equipamentos Científicos, Lda, Portugal
2000 - 2000
Concluded
 ICBT Training Course on Biopolymer Production (Curso médio)
Universidade de Coimbra, Portugal
2000 - 2000
Concluded
 Additives in Polymers (Curso médio)
Universidade de Coimbra, Portugal
1996 - 2000
Concluded
 Ciências da Visão (Mestrado)
Universidade de Coimbra, Portugal
"Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco" (THESIS/DISSERTATION)
 Muito bom
1998 - 1998
Concluded
 Curso de cromatografia líquida HPLC (Curso médio)
Soquímica - Sociedade de Representação de Química, Lda, Portugal
1996 - 1996
Concluded
 I Curso de Patologia Oftálmica (Curso médio)
Universidade de Coimbra, Portugal
1995
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Preparação de uma lente intra-ocular dotada de um sistemas de libertação controlada de fármaco – estudos preliminares" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2018/02/01 - 2021/08/31 Contracted Researcher (Research) PRODEQ - Associação para o desenvolvimento da Engenharia Química, Portugal
Universidade de Coimbra, Portugal
2003/07 - 2005/09 Research Trainee (Research) Bluepharma, Indústria Farmacêutica S.A., Portugal
1996/01 - 2000/05 Researcher (Research) Associação de Apoio ao Instituto Biomédico da Luz e da Imagem, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023/02/27 - 2023/07/15 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2021/02/21 - 2021/06/15 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Other Careers

Category
Host institution 		Employer
2005/10 - 2008/08 Técnico Superior (Técnico Superior) Bluepharma, Indústria Farmacêutica S.A., Portugal

Positions / Appointments

Category
Host institution 		Employer
2023/07/05 - Current President TIMEUP, Lda, Portugal
2017/09/15 - Current President INEYE PHARMA, Lda, Portugal

Others

Category
Host institution 		Employer
2021/02/01 - 2023/03/31 Consultant Pharmex Advanced Laboratories, S.A., Spain
Pharmex Advanced Laboratories, S.A., Spain
2008/09/01 - 2017/07/30 Responsável de setor - Desenvolvimento Analítico Bluepharma, Indústria Farmacêutica SA, Portugal
2003/01/01 - 2003/07/23 Professor de Físico-Química do 2º Ciclo do ensino básico Escola Pedro Teixeira, Portugal
Projects

Contract

Designation Funders
2018 - Current inEYE - Inserto ocular não invasivo para libertação controlada de fármacos
PTDC/EMD-EMD/31462/2017
Researcher
PRODEQ - Associação para o desenvolvimento da Engenharia Química, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/12/16 - 2021/08/31 CI19-0100 TimeUp
CI19-0100 TimeUp
Post-doc
Universidade de Coimbra, Portugal

Obra Social La Caixa, Spain
Obra Social La Caixa
Ongoing

Other

Designation Funders
2003/06 - 2005/09 Biostrat
P0068 POCTI/2.3
Researcher
Bluepharma, Indústria Farmacêutica S.A., Portugal
Concluded
1997/03 - 2000/03 Production of a new intraocular lens with drug controlled release
FARMALIO (L-1424)
Associação de Apoio ao Instituto Biomédico da Luz e da Imagem, Portugal
Concluded
1996/10 - 1999/10 Desenvolvimento de uma lente intraocular dotada de um sistema de libertação progressiva de fármaco
PRAXIS/2/2.1/SAU/1175/95
Master Student Fellow
Associação de Apoio ao Instituto Biomédico da Luz e da Imagem, Portugal
Concluded
Outputs

Publications

Conference abstract
  1. Santos, Gonçalo; Cernadas, Teresa; Ferreira, Paula; Braz, Berta; M Mariz; Delgado, Esmeralda. "Biocompatibility and tolerance of the ineye® insert in rabbits". Paper presented in Veterinary Ophthalmology, Berlin, 2021.
    Published
  2. M Mariz; Paula Ferreira. "ineye® - an ocular insert for simultaneous but distinct release profiles of moxifloxacin and flurbiprofen for ocular surgery prophylaxis". Paper presented in ARVO Annual Meeting 2020, 2020.
    Published
  3. Catarina Marques; Cernadas, Teresa; Ferreira, Paula; Braz, Berta; M Mariz; Delgado, Esmeralda. "Biocompatibility and tolerance of the ineye® insert in companion animals". Paper presented in European Society of Veterinary Ophthalmology Meeting, Dublin, 2019.
    Published
Conference paper
  1. Mariz, M.J.; Ferreira, P.C.; Gil, M.H.; Leite, E.. "A new intraocular lens that act as a drug delivery system. Part I - in vitro studies". Paper presented in Ever 2002, Alicante, 2002.
    Published
  2. Mariz, M.J.; Ferreira, P.C.; Gil, M.H.; Leite, E.. "A new intraocular lens that act as a drug delivery system. Part II - in vivo studies". Paper presented in EVER 2002, Alicante, 2002.
    Published
  3. Leite, E.; Mariz, M.J.; Ferreira, P.C.; Gil, M.H.. "A new intraocular lens that act as a drug delivery system - in vitro and in vivo studies". Paper presented in 17th European Conference on Biomaterials, Barcelona, 2002.
    Published
  4. Ferreira Marques, M.F.; Gordo, P.M.; Lopes Gil, C.; De Lima, A.P.; Kajcsos, Zs.; Gil, M.H.; Mariz, M.J.. "Estudo por espectroscopia de aniquiliação de positrões de polímeros vinílicos usados em lentes oftálmicas". Paper presented in 13ª Conferência Nacional de Física, Évora, 2002.
    Published
  5. Ferreira Marques, M.F.; Gordo, P.M.; Lopes Gil, C.; De Lima, A.P.; Kajcsos, Zs.; Gil, M.H.; Mariz, M.J.. "Positron lifetime studies in vinyl polymers". Paper presented in 7th International Workshop on Positron and Positronium Chemistry, Knoxwille, 2002.
    Published
  6. Aparício, A.; Mariz, M.J.; Baptirsta, C.; Gil, M.H.. "Preparação de sistemas de libertação controlada de fármacos de base quitosano". Paper presented in III Congresso Ibero-Americano em Ciências e Tecnologias de Membranas, Aveiro, 2001.
    Published
  7. Mariz, Marcos João Mota Leite Machado. "Imobilização de flurbiprofeno em mambranas vinílicas e subsequente libertação - o sistema membrana fármaco". Paper presented in III Congresso Ibero-Americano em Ciências e Tecnologias de Membranas, Aveiro, 2001.
    Published
  8. Mariz, M.J.; Ferreira, P.C.; Leite, E.; Schacht, E.. "Drug release from ney vinyl intraocular lenses". Paper presented in BioEng’2000 – 5th Portuguese Conference on Biomedical Engineering, Coimbra, 2000.
    Published
  9. Mariz, M.J.; Ferreira, P.C.; Leite, E.; Schacht, E.; Gil, M.H.. "Drug release from new intraocular lenses". Paper presented in 5th Portuguese Conference on Biomedical Engineering, Coimbra, 2000.
    Published
  10. Leite, E.; Gil, M.H.; Mariz, M.J.; Ferreira, P.C.. "Drug release intraocular delivery device". Paper presented in XII World Congress of International Society for Artificial Organs, Edimburgh, 1999.
    Published
  11. Mariz, Marcos João Mota Leite Machado; Leite, E.; Gil, M.H.; Mariz, M.J.; Ferreira, P.C.. "Drug release intraocular delivery device". Paper presented in Annual Meeting of ARVO, Fort Lauderdale, 1999.
    Published
  12. Cruz, M.L.; Mariz, M.J.; Paula Cristina Nunes Ferreira Calvinho; Gil, M.H.. "Antituberculosis macromolecular prodrugs. Part I: Isoniazid conjugates with polyethyleneglycol derivatives". Paper presented in 5TH European Symposium on Controlled Drug Delivery, Noordwijk, 1998.
    Published
  13. Mariz, M.J.; Leite, E.; Schacht, E.; Gil, M.H.. "Development of a drug delivery system based on acrylate monomers". Paper presented in 5TH European Symposium on Controlled Drug Delivery, Noordwijk, 1998.
    Published
  14. Mariz, M.J.; Ferreira, P.C.; Schacht, E.; Gil, M.H.; Leite, E.. "A new intraocular lens with controlled release of flurbiprofen". Paper presented in Ophthalmic Research- EVER 98, Palma de Maiorca, 1998.
    Published
  15. Mariz, M.J.; Ferreira, P.C.; Gil, M.H.; Leite, E.. "Preparação de uma lente intraocular dotada de um sistema de libertação controlada de fármaco". Paper presented in I Congresso de Investigação em Medicina, Coimbra, 1997.
    Published
  16. Ferreira, P.C.; Mariz, M.J.; Gil, M.H.; Leite, E.. "Preparação e caracterização de hidrogeis para aplicação em medicina". Paper presented in I Congresso de Investigação em Medicina, Coimbra, 1997.
    Published
  17. Mariz, M.J.; Ferreira, P.C.; Gil, M.H.; Leite, E.. "Preparation and characterisation of an IOL containing a drug". Paper presented in Ophthalmic Research- JERMOV 97, Montpellier, 1997.
    Published
  18. Mariz, M.J.; Sobral, L.M.; Ferreira, P.C.; Gil, M.H.; Leite, E.. "Drug entrapment in cellulosic membranes". Paper presented in Ophthalmic Research- JERMOV 97, Montpellier, 1997.
    Published
  19. Ferreira, P.C.; Mariz, M.J.; Gil, M.H.; Leite, E.. "Preparação de uma lente intraocular dotada de um sistema de libertação controlada de fármaco - Estudos preliminares". Paper presented in XXXIX Congresso da Sociedade Portuguesa de Oftalmologia, VI Jornadas de Investigação, Porto, 1996.
    Published
Journal article
  1. Mariz, M.; Murta, J.; Gil, M.H.; Ferreira, P.. "An ocular insert with zero-order extended delivery: Release kinetics and mathematical models". European Journal of Pharmaceutics and Biopharmaceutics 181 (2022): 79-87. http://dx.doi.org/10.1016/j.ejpb.2022.10.023.
    10.1016/j.ejpb.2022.10.023
  2. Santos, Marta; Mariz, Marcos; Tiago, Igor; Martins, Jimmy; Alarico, Susana; Ferreira, Paula. "A review on urinary tract infections diagnostic methods: Laboratory-based and point-of-care approaches". Journal of Pharmaceutical and Biomedical Analysis 219 (2022): 114889. http://dx.doi.org/10.1016/j.jpba.2022.114889.
    10.1016/j.jpba.2022.114889
  3. Ferreira Marques, M.F.; Gordo, P.M.; Lopes Gil, C.; Kajcsos, Zs.; Gil, M.H.; Mariz, M.J.; De Lima, A.P.. "Positron lifetime studies in vinyl polymers of medical importance". Radiation Physics and Chemistry 68 3-4 (2003): 485-488.
    Published
  4. Mariz, Marcos João Mota Leite Machado. "Polymeric biomaterials as drug delivery systems". Boletim de Biotecnologia – Biomateriais, 13-19, 72, 2002 72 (2002): 13-19.
    Published
Thesis / Dissertation
  1. Mariz, Marcos João Mota Leite Machado. "Ocular drug delivery insert technology: from polymer synthesis to in vitro testing". PhD, 2018. http://hdl.handle.net/10316/87591.
  2. "Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco.". Master, Universidade de Coimbra, 2000.

Intellectual property

Patent
  1. Mariz, Marcos João Mota Leite Machado; Paula Cristina Nunes Ferreira Calvinho; Maria Helena Mendes Gil; Joaquim Carlos Neto Murta. 2021. "Non-invasive ocular drug delivery insert technology". Russia.
    Granted/Issued
  2. Marcos João Mota Leite Machado Mariz; Paula Cristina Nunes Ferreira Calvinho; Maria Helena Mendes Gil; Joaquim Carlos Neto Murta. 2021. "Non invasive ocular drug delivery insert technology". United States.
    Pending
  3. Mariz, Marcos João Mota Leite Machado; Paula Cristina Nunes Ferreira Calvinho; Maria Helena Mendes Gil; Joaquim Carlos Neto Murta. 2019. "Non-invasive ocular drug delivery insert technology". Portugal.
    Granted/Issued
Trademark
  1. 2018. "ineye".
    Registered
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10 Biocompatibility and tolerance of the Ineye® Insert in rabbits ESVO 2021
European Society of Veterinary Ophthalmology (Berlim, Germany)
2019/10 Biocompatibility and tolerance of the ineye®¿ insert in companion animals European Society of Veterinary Ophthalmology Meeting
European Society of Veterinary Ophthalmology (Dublin, Ireland)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/02 - 2021/11 Otimização do perfil de libertação de fármacos de um inserto ocular de base polimérica
Supervisor
 Mestrado Integrado em Engenharia Química (Master)
Universidade de Coimbra, Portugal
2021/02 - 2021/11 Preparação de polímeros foto-reticuláveis para aplicação biomédica
Co-supervisor
 Mestrado Integrado em Engenharia Química (Master)
Universidade de Coimbra, Portugal
2019/10 - 2021/11 Scale-up de um processo de síntese do copolímero PCL-PEG
Supervisor
 Mestrado Integrado em Engenharia Química (Master)
Universidade de Coimbra, Portugal
2020/10 - 2021/07 Preparação de poliésteres foto-reticuláveis a partir de fontes renováveis
Co-supervisor
 Mestrado Integrado em Engenharia Química (Master)
Universidade de Coimbra, Portugal
2020/02 - 2021/05 Desenvolvimento de uma matriz polimérica para atração e concentração de bactérias, para aplicação num dispositivo médico
Co-supervisor
 Mestrado Integrado em Engenharia Química (Master)
Universidade de Coimbra, Portugal
2020/02/17 - 2021/01/18 Preparação de insertos oculares contendo ácido hialurónico para o tratamento do olho seco
Supervisor
 Mestrado Integrado em Engenharia Química (Master)
Universidade de Coimbra Departamento de Engenharia Quimica, Portugal
2015 - 2015 Desenvolvimento Galénico - Indústria Farmacêutica
Supervisor
 Biotecnologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012 - 2012 Measurement of active substance pills: development of a method by HPLC for Blue027 and a validation of a method by UPLC for Blue034
Supervisor
 Licenciatura em Biotecnologia (Degree)
Instituto Politécnico de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/07 Otimização de síntese de poliésteres insaturados para aplicações biomédicas
(Thesis) Arguer
 João Pedro Marques Pereira (Master)
Universidade de Coimbra, Portugal
2019/10 Desenvolvimento de compósitos de base dextrano para regeneração óssea
(Thesis) Arguer
 Ana Filipa Gouveia Simão (Master)
Universidade de Coimbra, Portugal

Consulting

Activity description Institution / Organization
2021/02 - Current Analytical methods, ICH guidelines and regulatory affairs for pharma industry Pharmex Advanced Laboratories, S.A., Spain

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
1999 - 1999 Curso avançado de cromatografia líquida HPLC Aperfeiçoamento (Curso médio) Associação para a Investigação Biomédica e Inovação em Luz e Imagem, Portugal

Interview (tv / radio show)

Program Topic
2017/12/30 - Current Mentes Brilhantes Communicate breaking-edge technology to society
Distinctions

Award

2023 Winner of 1st Edition of InsudPower
Insud Pharma, Spain
2019 Arrisca C 2018 - Menção honrosa - 2º lugar
Universidade de Coimbra, Portugal

Other distinction

2018 EIT Health Headstarts Awards 2018
EIT Health, Portugal
2017 PhD Transition Fellowship
EIT Health, Portugal
2017 3º Price of EIT Health Innostars, for Business Ideas, Italy, 2017 with the project "ineye - Healthy eyes for a lifetime", (an ocular insert with drug delivery technology)
EIT Health, Portugal
2017 Prémio "Melhor Ideia de Negócio", com o projeto inEYE (inserto para libertação de fármacos oculares)
IAPMEI, Portugal
2017 Prémio "ARRISCA C", na Tipologia "Ideias de Negócio"