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Identification

Personal identification

Full name
Maria Pedro Sucena Guarino

Citation names

  • Guarino, MP

Author identifiers

Ciência ID
F21A-BD01-2D52
ORCID iD
0000-0001-6079-1105

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2007
Concluded
 Fisiologia (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Caracterização da função do monóxido de azoto e glutationo hepáticos na sensibilidade periférica à insulina" (THESIS/DISSERTATION)
 Muito Bom com Distinção e Louvor
2003
Concluded
 Pharmacology and Therapeutics (Postgraduate Certificate)
University of Manitoba Faculty of Graduate Studies, Canada
"n/a" (THESIS/DISSERTATION)
 A+
2000
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Importância do monóxido de azoto na libertação da substância hepática sensibilizadora da insulina" (THESIS/DISSERTATION)
 16 valores
Affiliation

Teaching in Higher Education

2017/02/15 - Current Assistant Teacher (Polytechnic Teacher)
Instituto Politécnico de Leiria, Portugal
2015 - 2017 Invited Assistant Teacher (Polytechnic Teacher)
Instituto Politécnico de Leiria, Portugal
2013 - 2015 Assistant Teacher (Polytechnic Teacher)
Instituto Politécnico de Leiria Escola Superior de Saúde, Portugal
2008/01/01 - 2013/07/31 Assistant Professor (University Teacher)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2005 - 2007 Assistente (University Teacher)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2004/05/01 - 2005/12/31 Tutor (University Teacher)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Positions / Appointments

2013 - 2016 Conselho pedagógico
Instituto Politécnico de Leiria Escola Superior de Saúde, Portugal
Projects

Grant

Designation Funders
2014 - 2015/08 Mapping the sympathetic efferent activity in carotid-body mediated insulin resistance
Provided by PTCRIS: 135208
 Fundação para a Ciência e a Tecnologia
2009 - 2012/12 The relationship of circulating biomarkers of apoptosis and endothelial function with the plaque composition using VH IVUS
Provided by PTCRIS: 82734
 Fundação para a Ciência e a Tecnologia
2007 - 2010/03 Insulin sensitivity is regulated by hepatic glutathione and nitric oxide: a clinical and basic approach.
grant.Provided by PTCRIS: 82379
Research Fellow
Foundation for Science and Technology
2005 - 2008/06 Insulin sensitivity is regulated by hepatic glutathione and nitric oxide: a clinical and basic approach.
grant.Provided by PTCRIS: 56716
Research Fellow
Foundation for Science and Technology
2001 - 2005 CARACTERIZAÇÃO DA FUNÇÃO DO MONÓXIDO DE AZOTO E GLUTATIONO HEPÁTICOS NA SENSIBILIDADE PERIFÉRICA À INSULINA
SFRH/BD/4916/2001
PhD Student Fellow
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Contract

Designation Funders
2017 - 2019/09/18 Plataforma de Monitorização da Atividade Física / Physical Activity Monitoring Platform
SAICT-POL/23878/2016
Researcher
Politécnico de Leiria - ciTechCare, Portugal
 Fundação para a Ciência e a Tecnologia
2017 - 2019/03 CBmeter- a new medical device for screening metabolic diseases
SAICT-POL/23278/2016
Principal investigator
Politécnico de Leiria - ciTechCare, Portugal
 Ministério da Ciência Tecnologia e Ensino Superior
2014 - 2015/08 Mapping the sympathetic efferent activity in carotid-body mediated insulin resistance
grant.Provided by PTCRIS: 135208
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Foundation for Science and Technology
2012 - 2015/08 GERIA-Geriatric study in Portugal on Health Effects of Air Quality in Elderly Care Centers
grant.Provided by PTCRIS: 116563
Researcher
Foundation for Science and Technology
2011 - 2013/12 Is insulin a stimulus for carotid body activation? A new mechanism for insulin resistance and hypertension.
grant.Provided by PTCRIS: 111417
Researcher
Foundation for Science and Technology
2010 - 2013/08 Environment and Health in children day care centres (ENVIRH)
grant.Provided by PTCRIS: 100275
Researcher
Foundation for Science and Technology
2009 - 2012/12 The relationship of circulating biomarkers of apoptosis and endothelial function with the plaque composition using VH IVUS
grant.Provided by PTCRIS: 82734
Researcher
Foundation for Science and Technology
Outputs

Publications

Book
  1. Vera-Cruz, P.; Guerreiro, F.; Ribeiro, M.J.; Guarino, M.P.; Conde, S.V.. 2015. Hyperbaric oxygen therapy improves glucose homeostasis in type 2 diabetes patients: A likely involvement of the carotid bodies. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940043451&partnerID=MN8TOARS.
    10.1007/978-3-319-18440-1_24
  2. Guarino, M.P.; Sacramento, J.; Ribeiro, M.J.; Conde, S.V.. 2014. Caffeine, Insulin Resistance, and Hypertension. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943327530&partnerID=MN8TOARS.
    10.1016/B978-0-12-409517-5.00083-8
Book review
  1. Martins, Jose D.; Zachariah, Justin; Tierney, Elif Seda Selamet; Truong, Uyen; Morris, Shaine A.; Kutty, Shelby; De Ferranti, Sarah D.; et al. "Rationale and design of long-term outcomes and vascular evaluation after successful coarctation of the aorta treatment study". http://www.scopus.com/inward/record.url?scp=85053328979&partnerID=8YFLogxK.
    https://doi.org/10.4103/apc.APC_64_18
Conference paper
  1. Frazão, Ana; Costa, Andreia; Teixeira, Bárbara; Santo, Marisa; Brito, Gabriel; Lajes, Marlene; Lopes, Nuno Vieira; et al. 2018. "Development of a mixed-meal that impacts carotid-body mediated cardiorespiratory and metabolic parameters - a pilot study". Portugal: Acta Portuguesa de Nutrição.
  2. Guarino, Maria Pedro; Brito, Gabriel; Lajes, Marlene; Fonseca-Pinto, Rui; Vieira Lopes, Nuno. 2018. "CBmeter- a new medical device for early screening of metabolic diseases". Portugal: BMC Health Services Research.
Journal article
  1. Conde, S.V.; Sacramento, J.F.; Guarino, M.P.. 2018. "Carotid body: A metabolic sensor implicated in insulin resistance". Physiological Genomics 50 (3): 208-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052514682&partnerID=MN8TOARS.
    10.1152/physiolgenomics.00121.2017
  2. Martins, J.D.; Zachariah, J.; Tierney, E.S.S.; Truong, U.; Morris, S.A.; Kutty, S.; De Ferranti, S.D.; et al. 2018. "Rationale and design of long-term outcomes and vascular evaluation after successful coarctation of the aorta treatment study". Annals of Pediatric Cardiology 11 (3): 282-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053328979&partnerID=MN8TOARS.
    10.4103/apc.APC_64_18
  3. Ribeiro, M.J.; Sacramento, J.F.; Gallego-Martin, T.; Olea, E.; Melo, B.F.; Guarino, M.P.; Yubero, S.; Obeso, A.; Conde, S.V.. 2018. "High fat diet blunts the effects of leptin on ventilation and on carotid body activity". Journal of Physiology 596 (15): 3187-3199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040577382&partnerID=MN8TOARS.
    10.1113/JP275362
  4. Sacramento, J.F.; Chew, D.J.; Melo, B.F.; Donegá, M.; Dopson, W.; Guarino, M.P.; Robinson, A.; et al. 2018. "Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes". Diabetologia 61 (3): 700-710. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041512413&partnerID=MN8TOARS.
    10.1007/s00125-017-4533-7
  5. Sacramento, J.F.; Ribeiro, M.J.; Rodrigues, T.; Olea, E.; Melo, B.F.; Guarino, M.P.; Fonseca-Pinto, R.; et al. 2017. "Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver". Diabetologia 60 (1): 158-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991325548&partnerID=MN8TOARS.
    10.1007/s00125-016-4133-y
  6. Franco, M.C.; Fonseca, A.R.; Sacramento, J.; Melo, B.; Conde, S.V.; Guarino, M.P.. 2017. "Micro Computed Tomography Detects Changes in Liver Density in Control and in Prediabetes Rats". Procedia Manufacturing 12: 106-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029842099&partnerID=MN8TOARS.
    10.1016/j.promfg.2017.08.014
  7. Conde, S.V.; Ribeiro, M.J.; Melo, B.F.; Guarino, M.P.; Sacramento, J.F.. 2017. "Insulin resistance: a new consequence of altered carotid body chemoreflex?". Journal of Physiology 595 (1): 31-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-84977560724&partnerID=MN8TOARS.
    10.1113/JP271684
  8. Sacramento, J.F.; Ribeiro, M.J.; Rodrigues, T.; Guarino, M.P.; Diogo, L.N.; Seiça, R.; Monteiro, E.C.; Matafome, P.; Conde, S.V.. 2016. "Insulin resistance is associated with tissue-specific regulation of HIF-1a and HIF-2a during mild chronic intermittent hypoxia". Respiratory Physiology and Neurobiology 228: 30-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961279467&partnerID=MN8TOARS.
    10.1016/j.resp.2016.03.007
  9. Sacramento, J.F.; Ribeiro, M.J.; Yubero, S.; Melo, B.F.; Obeso, A.; Guarino, M.P.; Gonzalez, C.; Conde, S.V.. 2015. "Disclosing caffeine action on insulin sensitivity: Effects on rat skeletal muscle". European Journal of Pharmaceutical Sciences 70: 107-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922754845&partnerID=MN8TOARS.
    10.1016/j.ejps.2015.01.011
  10. Conde, S.V.; Sacramento, J.F.; Guarino, M.P.; Gonzalez, C.; Obeso, A.; Diogo, L.N.; Monteiro, E.C.; Ribeiro, M.J.. 2014. "Carotid body, insulin and metabolic diseases: Unravelling the links". Frontiers in Physiology 5 (OCT). http://www.scopus.com/inward/record.url?eid=2-s2.0-84908396381&partnerID=MN8TOARS.
    10.3389/fphys.2014.00418
  11. Guarino, Maria. 2013. "Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets". Diabetes.
    10.2337/db12-1463
  12. Pinto, P.; Bárbara, C.; Montserrat, J.M.; Patarrão, R.S.; Guarino, M.P.; Carmo, M.M.; Macedo, M.P.; et al. 2013. "Effects of CPAP on nitrate and norepinephrine levels in severe and mild-moderate sleep apnea". BMC Pulmonary Medicine 13 (1). http://www.scopus.com/inward/record.url?eid=2-s2.0-84874806261&partnerID=MN8TOARS.
    10.1186/1471-2466-13-13
  13. Guarino, M.P.; Santos, A.I.; Mota-Carmo, M.; Costa, P.F.. 2013. "Effects of anaesthesia on insulin sensitivity and metabolic parameters in Wistar rats". In Vivo 27 (1): 127-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872740659&partnerID=MN8TOARS.
  14. Guarino, M.P.; Ribeiro, M.J.; Sacramento, J.F.; Conde, S.V.. 2013. "Chronic caffeine intake reverses age-induced insulin resistance in the rat: Effect on skeletal muscle Glut4 transporters and AMPK activity". Age 35 (5): 1755-1765. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892616536&partnerID=MN8TOARS.
    10.1007/s11357-012-9475-x
  15. Conde, S.V.; Nunes Da Silva, T.; Gonzalez, C.; Mota Carmo, M.; Monteiro, E.C.; Guarino, M.P.. 2012. "Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats". British Journal of Nutrition 107 (1): 86-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855787744&partnerID=MN8TOARS.
    10.1017/S0007114511002406
  16. Fernandes, A.B.; Guarino, M.P.; Macedo, M.P.. 2012. "Understanding the in-vivo relevance of S-nitrosothiols in insulin action". Canadian Journal of Physiology and Pharmacology 90 (7): 887-894. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863707319&partnerID=MN8TOARS.
    10.1139/Y2012-090
  17. Ribeiro, T.; Afonso, R.A.; Guarino, M.P.; Macedo, M.P.. 2008. "Loss of postprandial insulin sensitization during aging". Journals of Gerontology - Series A Biological Sciences and Medical Sciences 63 (6): 560-565. http://www.scopus.com/inward/record.url?eid=2-s2.0-50949133141&partnerID=MN8TOARS.
  18. Patarrão, R.S.; Lautt, W.W.; Afonso, R.A.; Ribeiro, R.T.; Guarino, M.P.; Fernandes, A.B.; Boavida, J.M.; Macedo, M.P.. 2008. "Meal-induced insulin sensitization and its parasympathetic regulation in humans". Canadian Journal of Physiology and Pharmacology 86 (12): 880-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349087711&partnerID=MN8TOARS.
    10.1139/Y08-080
  19. Patarrão, R.S.; Wayne Lautt, W.; Guarino, M.P.; Afonso, R.A.; Ribeiro, R.T.; Fernandes, A.B.; Boavida, J.M.; Macedo, M.P.. 2007. "A new technique to assess insulin sensitivity in humans: The Rapid Insulin Sensitivity Test (RIST)". Proceedings of the Western Pharmacology Society 50: 105-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-47749092863&partnerID=MN8TOARS.
  20. Santos, C.; Afonso, R.A.; Guarino, M.P.; Patarrão, R.S.; Fernandes, A.; Noronha, J.P.; Macedo, M.P.; Caldeira, J.. 2006. "In vitro nitrosation of insulin A- and B-chains". European Journal of Mass Spectrometry 12 (5): 331-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947235132&partnerID=MN8TOARS.
    10.1255/ejms.835
  21. Guarino, M.P.; Macedo, M.P.. 2006. "Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats". British Journal of Pharmacology 147 (8): 959-965. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646565956&partnerID=MN8TOARS.
    10.1038/sj.bjp.0706691
  22. Lautt, W.W.; Macedo, M.P.; Sadri, P.; Legare, D.J.; Reid, M.A.G.; Guarino, M.P.. 2004. "Pharmaceutical reversal of insulin resistance". Proceedings of the Western Pharmacology Society 47: 30-32. http://www.scopus.com/inward/record.url?eid=2-s2.0-9444283195&partnerID=MN8TOARS.
  23. Guarino, M.P.; Correia, N.C.; Lautt, W.W.; Macedo, M.P.. 2004. "Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver". American Journal of Physiology - Gastrointestinal and Liver Physiology 287 (3 50-3). http://www.scopus.com/inward/record.url?eid=2-s2.0-4143083738&partnerID=MN8TOARS.
    10.1152/ajpgi.00085.2004
  24. Guarino, M.P.; Afonso, R.A.; Raimundo, N.; Raposo, J.F.; Macedo, M.P.. 2003. "Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action". American Journal of Physiology - Gastrointestinal and Liver Physiology 284 (4 47-4). http://www.scopus.com/inward/record.url?eid=2-s2.0-0037378242&partnerID=MN8TOARS.
  25. Cruz Correia, N.; Pedro Guarino, M.; Raposo, J.; Macedo, M.P.. 2002. "Hepatic guanylyl cyclase inhibition induces HISS-dependent insulin resistance". Proceedings of the Western Pharmacology Society 45: 57-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036035911&partnerID=MN8TOARS.
  26. Guarino, M.P.; Correia, N.C.; Raposo, J.; Macedo, M.P.. 2001. "Nitric oxide synthase inhibition decreases output of hepatic insulin sensitizing substance (HISS), which is reversed by SIN-1 but not by nitroprusside". Proceedings of the Western Pharmacology Society 44: 25-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035699836&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Sacramento, Joana Filipa Canais da Costa. 2012. "Cafeína e resistência à insulina: qual o papel da adenosina?". Mestrado. http://hdl.handle.net/10362/13960.
  2. Guarino, Maria Pedro Sucena. 2007. "Caracterização da função do monóxido de azoto e glutationo hepáticos na sensabilidade periférica à insulina". Doutoramento. http://hdl.handle.net/10362/5203.

Other

Other output
  1. Braga-Pontes, Cátia; Simões-Dias, Sara; Guarino, Maria Pedro. 2015. Determinação da idade crítica para o aparecimento de obesidade infantil. A obesidade infantil constitui atualmente um grave problema de saúde pública. De acordo com a Organização Mundial de Saúde a obesidade infantil é um forte preditor de obesidade no adulto, incrementando o risco de desenvolvimento de doenças crónicas e representando um dos mais sérios desafios que a Europa terá de superar nos próximos anos.O estudo tem como objetivos: determinar a idade crítica para. https://journals.ipleiria.pt/index.php/rnhealth/article/view/52.
  2. Pinto, Paula; Bárbara, Cristina; Montserrat,  Josep M.; Patarrão, Rita; Guarino, Maria P.; Carmo, Miguel Mota; Macedo, Maria P.; et al. 2013. Effects of CPAP on nitrate and norepinephrine levels in severe and mild-moderate sleep apnea. Background: Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP). The effect of CPAP on these biomarkers in mild-moderate OSA is not well understood. The aim of this study was to compare NOx and U-NE levels and blood pressure (BP) between mal. http://hdl.handle.net/10362/24268.
    https://doi.org/10.1186/1471-2466-13-13
  3. Conde, Silvia; Silva, Tiago Nunes da; Gonzalez, Constancio; Carmo, Miguel Mota; Monteiro, Emília C; Guarino, Maria P; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centro de Estudos de Doenças Crónicas (CEDOC). 2012. Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. We tested the hypothesis that long-term caffeine intake prevents the development of insulin resistance and hypertension in two pathological animal models: the high-fat (HF) and the high-sucrose (HSu.) diet rat. We used six groups of animals: control; caffeine-treated (Gaff; 1 g/l in drinking water during 15 d); HF; caffeine-treated HF (HFCaff); HSu; caffeine-treated HSu (HSuCaff). Insulin sensitiv. http://hdl.handle.net/10362/21912.
    https://doi.org/10.1017/S0007114511002406
Distinctions

Award

2019 Bragança Parreira Award
Sociedade Portuguesa de Diabetologia, Portugal
2012 HARGREAVES 2012 Award
Sociedade Portuguesa de Diabetologia, Portugal
2010 Thomé Villar "Boehringer Ingelheim" 2010 Award
Sociedade Portuguesa de Pneumologia, Portugal
2009 Nuno Castelo Branco Award
Sociedade Portuguesa de Diabetologia, Portugal
2008 Hargreaves 2008 Award
Sociedade Portuguesa de Diabetologia, Portugal
2006 Hargreaves 2006 Award
Sociedade Portuguesa de Diabetologia, Portugal
2006 Sá Marques/SPD 2006 Award
Sociedade Portuguesa de Diabetologia, Portugal
2004 Young Investigator Award
SFRRI - Society for Free Radical Research International, United Kingdom
2004 TRAVEL AWARD - 40TH EASD MEETING, MUNICH, GERMANY
European Association for the Study of Diabetes, Germany
2003 1st Prize: SPEDM/ABBOT for Investigation in Obesity
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo (SPEDM), Portugal
2002 Dr. Ernesto Roma Award- Roche Diagnostics
Associação Protectora dos Diabéticos de Portugal (APDP), Portugal
2002 Outstanding Poster Presentation
Western Pharmacology Society, Canada