Filipa Juliana Fernandes Castro Freitas (F11F-1863-D018)

Curriculum Vitae

Filipa Juliana Fernandes Castro Freitas

Filipa completed her Master in Biological Engineering at the University of Minho (UMinho) in 2008. In 2013, she completed her PhD thesis in Bioengineering at UMinho under the MIT-Portugal program. The main purpose of her PhD thesis was to apply scaled-down reactors for the process intensification of hydroxyapatite precipitation. The thesis was done with the collaboration of the Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE) of the Faculty of Engineering of the University of Porto (FEUP) and the Jensen Research Group from the Massachusetts Institute of Technology (MIT). After a Post-Doctoral position at the Centre of Biological Engineering (CEB) (UMinho), Filipa joined the Supramolecular Assemblies group of LEPABE (FEUP) under a FCT Post-Doctoral fellowship. From September 2018 to June 2023, she was a Junior Researcher at FEUP as part of ALiCE - Associate Laboratory in Chemical Engineering/LEPABE and the research line of Supramolecular Assemblies. From July 2023 to October 2024, Filipa was an Assistant Researcher at CEB (UMinho) under the 5th edition of the Stimulus Competition for Individual Scientific Employment (CEEC Individual). Currently, she is an Assistant Researcher at LABBELS (Associate Laboratory in Biotechnology and Bioengineering and Microelectromechanical Systems)/CEB. She is part of the Biomass, Bioreactors and Bioproducts for industrial applications research line. Her research focuses on the development of a unique platform for the crystallization of biomolecules by combining (1) nucleation control strategies and (2) oscillatory flow crystallizers together with (3) process analytical technology (PAT) and (4) process modeling. Filipa is the Principal Researcher of the project 2023.11352.PEX - An innovative strategy towards the sustainable separation of whey proteins, which aims to develop a cost-effective and scalable platform for the selective crystallization of whey proteins. Filipa is also part of the coordination of the MSCA-DN PROCRYSTAL-101169471, "Crystallisation towards efficient and sustainable biomanufacturing". PROCRYSTAL will train 15 doctoral students with special attention to fundamental understanding of the underlying phenomena of biomolecules crystallisation, from the molecular scale to process scale, and advanced experimental and modelling techniques specific to crystallisation technology. She is one the of the authors of the granted patent "Modular Oscillatory Flow Plate Reactor" EP3439773 (B1). She has also been engaged with Science Communication and Outreach and participated at the UPorto EMERGENCE Hackathon (2021). She has published 3 book chapters and 25 scientific papers in international peer review journals with an h-index of 14 in Chemical Engineering, Crystallization and Materials fields. Filipa is a reviewer of several international journals including Industrial & engineering chemistry research. She is currently supervising a Master student. She supervised 2 PhD and 6 MSc theses. Filipa got different distinctions: FEUP scientific recognition award (2023); best student award (Prémio Universidade do Minho 2008); PhD fellowship FCT (SFRH / BD / 42992 / 2008) and Post-Doc fellowship (SFRH/BPD/96132/2013).

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Identification

Personal identification

Full name: Filipa Juliana Fernandes Castro Freitas

Citation names

Castro, Filipa

Author identifiers

Ciência ID: F11F-1863-D018
ORCID iD: 0000-0001-7447-4063

Email addresses

filipa.castro@ceb.uminho.pt (Professional)
filipa.castro@ceb.uminho.pt (Professional)

Telephones

Telephone

225081400 (Professional)

Addresses

Centro de Engenharia Biológica da Universidade do Minho, 4710-057 , Gualtar, Braga, Portugal (Professional)

Knowledge fields

Engineering and Technology - Chemical Engineering
Engineering and Technology - Industrial Biotechnology - Bioprocessing Technologies

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)
Italian	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
German

Education

	Degree	Classification
2024/11 - 2025 Ongoing	IMFAHE´s Global Platform of Talent 2024-2025 (Outros) Universidade do Minho, Portugal
2024/11/06 - 2024/11/27 Concluded	Avaliação+ (Outros) Universidade do Minho, Portugal
2024/10/03 - 2024/10/04 Concluded	Docência+Impulso (Outros) Universidade do Minho, Portugal
2014/12/01 - 2018/08/31 Concluded	Application of micro and meso reactors for protein crystallization for both three-dimensional structure determination and technical-scale protein purification (Pós-doutoramento) Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2017 Concluded	Transferable skills for Engineering: pedagogical training (Outros) Universidade do Porto Faculdade de Engenharia, Portugal
2016/06 - 2016/06 Concluded	Summer School on Crystal Nucleation: Fundamentals and Application (Outros) CMAC Future Manufacturing Research Hub, United Kingdom
2015/05 - 2015/05 Concluded	International school on bioloical crystallization - ISCB (Outros) The Laboratory of Crystallographic Studies (LEC) , Spain
2013/07/01 - 2014/11/30 Concluded	Biotechnology and Bioengineering for improved Industrial and Agro-Food processes (Pós-doutoramento) Universidade do Minho Centro de Engenharia Biológica, Portugal
2013 Concluded	Programa doutoral MIT-Portugal (Doutoramento) Universidade do Minho Escola de Engenharia, Portugal "Process Intensification for the Production of Hydroxyapatite Nanoparticles" (THESIS/DISSERTATION)	Aprovado
2008 Concluded	Mestrado Integrado em Engenharia Biológica (Mestrado) Universidade do Minho Escola de Engenharia, Portugal "Development of methodologies of characterization for complex cell structures: case of the yeast Saccharomyces cerevisiae" (THESIS/DISSERTATION)	17/20

Affiliation

Science

	Category Host institution	Employer
2024/10/07 - Current	Auxiliary Researcher (Research)	Universidade do Minho Centro de Engenharia Biológica, Portugal

2023/07/01 - 2024/10/06	Contracted Researcher (Research)	Universidade do Minho Centro de Engenharia Biológica, Portugal
	Universidade do Minho Centro de Engenharia Biológica, Portugal
2018/09/03 - 2023/06/30	Contracted Researcher (Research)	Universidade do Porto Faculdade de Engenharia, Portugal
	Universidade do Porto Faculdade de Engenharia, Portugal
2014/12/01 - 2018/08/31	Postdoc (Research)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Engenharia, Portugal
2013/07/01 - 2014/11/30	Postdoc (Research)	Universidade do Minho Centro de Engenharia Biológica, Portugal

2013/04/01 - 2013/06/30	Researcher (Research)	Universidade do Minho Centro de Engenharia Biológica, Portugal

Others

	Category Host institution	Employer
2011/09/01 - 2013/06/01	High school students tutoring	Centro de estudo Links, Portugal

2007/08/01 - 2007/08/31	Secretary	Junta de Freguesia de Fornelos, Portugal

2001/06/01 - 2001/06/30	Cleaning assistant	"Les Floralies" - Maison de retraite, France

Projects

Grant

	Designation	Funders
2025/01 - 2028/12	PROCRYSTAL - Crystallisation towards efficient and sustainable biomanufacturing 101169471 Co-Principal Investigator (Co-PI) Universidade do Minho, Portugal	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Ongoing
2020/01/01 - 2023	Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia UIDB/00511/2020_UIDP/00511/2020 Researcher	Ongoing
2014/12/01 - 2018/08/31	Application of micro and meso reactors for protein crystallization for both three-dimensional structure determination and technical-scale protein purification. SFRH/BPD/96132/2013 Post-doc Fellow Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07/01 - 2014/11/30	Biotechnology and Bioengineering for improved Industrial and Agro-Food processes NORTE-07-0124-FEDER-000028 Post-doc Fellow Universidade do Minho Centro de Engenharia Biológica, Portugal	Concluded
2008/08 - 2013/04	Process Intensification for the Production of Hydroxyapatite Nanoparticles SFRH / BD / 42992 / 2008 PhD Student Fellow Universidade do Minho Centro de Engenharia Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2025/01/01 - 2026/06/30	An innovative strategy towards the sustainable separation of whey proteins 2023.11352.PEX 10.54499/2023.11352.PEX Principal investigator Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Associate Laboratory on Biotechnology, Bioengineering and microELectromechanical Systems LA/P/0029/2020 10.54499/LA/P/0029/2020 Researcher Universidade do Minho, Portugal Universidade do Minho Centro de Engenharia Biológica, Portugal Universidade do Minho Labbels, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2024/12/31	Centre of Biological Engineering of the University of Minho UIDB/04469/2020 10.54499/UIDB/04469/2020 Researcher Universidade do Minho, Portugal Universidade do Minho Centro de Engenharia Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2023/07/01 - 2024/10/06	Continuous crystallization as a cost-effective and scalable technique for the selective separation/purification of proteins 2022.06818.CEECIND/CP1718/CT0022 Principal investigator Universidade do Minho Centro de Engenharia Biológica, Portugal	Fundação para a Ciência e a Tecnologia
2020/01/01 - 2023/12/31	Laboratory for Process Engineering, Environment, Biotechnology and Energy UIDP/00511/2020 10.54499/UIDP/00511/2020 UIDB/00511/2020 10.54499/UIDB/00511/2020 Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal Instituto Politécnico de Leiria, Portugal Universidade do Porto Centro de Estudos de Fenómenos de Transporte, Portugal Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021/01/01 - 2023/06/30	ALICE - Associate Laboratory in Chemical Engineering LA/P/0045/2020 10.54499/LA/P/0045/2020 Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal Instituto Politécnico de Leiria, Portugal Universidade do Porto Centro de Estudos de Fenómenos de Transporte, Portugal Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/04/01 - 2019/09/30	LEPABE-2-ECO-INNOVATION NORTE-01-0145-FEDER-000005 Researcher Universidade do Porto Faculdade de Engenharia, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Ongoing
2016/07/01 - 2019/06/30	CrystalFlow - Cristalização em contínuo de princípios ativos PTDC/QEQ-PRS/3787/2014 – POCI-01-0145-FEDER-016816 Researcher Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/07/01 - 2019/06/30	Continuous crystallization of active pharmaceutical ingredients APIs PTDC/QEQ-PRS/3787/2014 Universidade do Minho, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015/01/01 - 2018/12/31	Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939 Researcher Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Joana Maria Pereira Ferreira; Castro, Filipa. Corresponding author: Castro, Filipa. "High-throughput protein crystallization in an integrated droplet-based microfluidic platform". In Advanced Methods in Structural Biology, edited by Ângela Maria Almeida de Sousa; Luís Passarinha. New York, United States: Springer Nature Switzerland AG, 2023. Accepted Anabela Veiga; Castro, Filipa; Fernando Rocha; Beatriz Bernardes; Marta M. Duarte; Ana Leite Oliveira. "Opening New Avenues for Bioceramics: Oscillatory Flow Reactors and Upcoming Technologies in Skin-Tissue Engineering". In Solid State Phenomena, 79-87. 2022. 10.4028/p-1f087p Castro, Filipa; Ribeiro da Silva, Nuno; Silverio, Sara I.; Ballesteros, Lina F.; Teixeira, José António. "Unit operations in extraction and purification of biological products". In Advances in Bioprocess Engineering. 2022. Accepted
Conference abstract	A., Veiga; Castro, F.; Rocha, F.; Oliveira, A.L.. "A simple and controlled method for the continuous production of calcium/sericin-based composites". Paper presented in SEJIPOL2020-21 \| The 5th Young Polymer Scientists Seminar, Madrid, 2021. Published Ferreira, J.; Castro, F.; Rocha, F.; Kuhn, S.. "Enhanced control of protein crystallization in droplet-based microfluidics". Paper presented in ACCGE-22/ OMVPE-20 \| The 22nd American Conference on Crystal Growth and Epitaxy and 20th U.S. Biennial Workshop on Organometallic Vapor Phase Epitaxy, 2021. Published Ferreira, J.; Castro, F.; Rocha, F.; Kuhn, S.. "Droplet microfluidic devices for protein crystallization". Paper presented in 17th International Conference on the Crystallization of Biological Macromolecules (ICCBM17), Shanghai, 2018. Published Ferreira, J.; Castro, F.; Rocha, F.; Kuhn, S.. "Hydrodynamics and mixing dynamics in droplet-based microfluidics for protein crystallization". Paper presented in AIChE Meeting, 8th World Congress on Particle Technology (WCPT8), Orlando, 2018. Published Castro, Filipa; António Ferreira; José António Teixeira; Fernando Rocha. "Effect of mixing intensity on lysozyme crystallization in a meso oscillatory flow reactor". Paper presented in 8th World Congress on Particle Technology : Proceedings : Particle Design : Crystallization I, Orlando, 2018. Published
Conference paper	Castro, Filipa; Ribeiro, V. P.; Ferreira, António; Oliveira, A. L.; Reis, R. L.; Teixeira, J. A.; Rocha, Fernando. "Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite". Paper presented in MicroBiotec'15 - Congress of Microbiology and Biotechnology, Évora, 2015. Castro, Filipa; Kuhn, S.; Jensen, K.; Ferreira, António; Rocha, F.; Vicente, A. A.; Teixeira, J. A.. "Uso de microsistemas na precipitação em contínuo de hidroxiapatite". Paper presented in COBEQ 2012 - XIX Congresso Brasileiro de Engenharia Química., Búzios, 2012. Castro, Filipa; Kuhn, Simon; Jensen, Klavs; Ferreira, Antonio; Rocha, Fernando; Vicente, António; Teixeira, José António. "Process intensification and optimization for hydroxyapatite nanoparticles production". Paper presented in 3rd MIT Portugal Conference - Excellence in Engineering for Innovation in Global Markets, Guimarães, 2012. Castro, Filipa; Ferreira, António; Rocha, F. A.; Teixeira, J. A.. "Protein crystallization in a new meso oscillatory flow reactor". Paper presented in Semana da Escola de Engenharia 2011 - Uma Escola a Reinventar o Futuro, Guimarães, 2011. Castro, Filipa. "A comparative study on hydroxyapatite precipitation in a stirred tank and in an oscillatory flow meso-reactor". Paper presented in Semana da Escola de Engenharia 2011 - Uma Escola a Reinventar o Futuro, Guimarães, 2011. Castro, Filipa. "Novaflow : novel applications of a state-of-the-art oscillatory flow platform : hydroxyapatite production and its use in bone extracellular matrix growth". Paper presented in Semana de Engenharia, Guimarães, 2010. Castro, Filipa; Ferreira, A. M. A.; Teixeira, J. A.; Vicente, A. A.; Rocha, F. A.; Oliveira, A. L.. "Novaflow : novel applications of a state-of-the-art oscillatory flow platform : hydroxyapatite production and its use in bone extracellular matrix growth". Paper presented in Creating Value through Systems Thinking - Proceedings of the 2nd MIT Portugal Annual Conference., Porto, 2010. Castro, Filipa; Teixeira, J. A.; Vicente, A. A., NovaFlow Novel applications of a state-of-the-art oscillatory flow platform: hydroxyapatite production and its use in bone extracellular matrix growth. Creating Value through Systems Thinking - Proceedings
Conference poster	Castro, Filipa; Ferreira, António; Rocha, Fernando; Teixeira, José A.. Corresponding author: Castro, Filipa. "Investigation of insulin nucleation kinetics under oscillatory flow mixing". Paper presented in ChemPor, 2023. Anabela Alves Veiga; Castro, Filipa; Ana Leite Oliveira; Fernando Alberto Nogueira da Rocha. "Modular oscillatory flow reactor as a new technology for the continuous production of customized Calcium Phosphates for tissue engineering". Paper presented in Bioceramics 32 \| Symposium and Annual Meetings of the International Society for Ceramics in Medicine, 2022. Anabela Alves Veiga; Castro, Filipa; Fernando Alberto Nogueira da Rocha; Blanca Vázquez-Lasa; Luis Rojo; Ana Leite Oliveira. "Ready-to-use silkworm sericin: finding the best starting point". Paper presented in ESB 32 \| 32nd Annual Conference of the European Society for Biomaterials, 2022. A., Veiga; Magalhães, R.; Castro, F.; Rocha, F.; Oliveira, A.L.. "Fabrication of highly tuned Calciumphosphate/silk sericin composites: exploring new pathways on skin regeneration". Paper presented in ESB 2021 \| The 31st Annual Conference of the European Society for Biomaterials, 2021. Castro, F.; Ferreira, A.; Teixeira, J.A.; Rocha, F.. "Seeded batch protein crystallization in a meso oscillatory flow reactor". Paper presented in ISIC 21 \| The 21st International Symposium on Industrial Crystallization, 2021. Veiga, A.; Magalhães, R.; Castro, F.; Rocha, F.; Oliveira, A.L.. "Continuous production of Hydroxyapatite/sericin composites: and in vitro validation for skin regeneration". Paper presented in Ciência 21 \| Science and Technology in Portugal Summit, 2021. Ferreira, J.; Castro, F.; Rocha, F.; Kuhn, S.. "Droplet-based microfluidic platform for protein crystallization". Paper presented in DCE17 \| 2nd Doctoral Congress of Engineering, 2017. 10.1109/icsens.2016.7808677 Ferreira, J.; Castro, F.; Rocha, F.; Kuhn, S.. "Lysozyme crystallization in a droplet-based microfluidic platform". Paper presented in ISBC17 \| 6th International School on Biological Crystallization, 2017. Veiga, A.; Castro, F.; Oliveira, A. L.; Rocha, F.. "Nanocomposites of Hydroxyapatite and Sericin". Paper presented in WBME \| 9th Workshop on Biomedical Engineering, 2017. Veiga, Anabela; Castro, Filipa; Oliveira, Ana Leite; Rocha, Fernando. "Synthesis of Hydroxyapatite/Sericin nanocomposites". Paper presented in DCE17 \| 2nd Doctoral Congress of Engineering, 2017. Castro, Filipa; Kuhn, Simon; Jensen, Klavs; Ferreira, António; Rocha, Fernando; Vicente, António; Teixeira, José António. "Uso de microsistemas na precipitação em contínuo de hidroxiapatite". Paper presented in COBEQ-XIX \| Congresso Brasileiro de Engenharia Química, 2012.
Journal article	Filipe José Pires Almeida; Castro, Filipa; Teixeira, José António; Fernando Alberto Nogueira da Rocha; António Manuel Azevedo Ferreira. Corresponding author: António Manuel Azevedo Ferreira. "Effect of high solids loading on gas–liquid mass transfer in an oscillatory flow reactor for process intensification". Chemical Engineering Science 300 (2024): 120600. Published Joana Ferreira; Sofia Araújo; António Ferreira; José Teixeira; João Moreira de Campos; Fernando Rocha; Filipa Castro. "Insulin nucleation kinetics in an oscillatory flow-based platform: Protein crystallization as a highly reproducible separation process". Chemical Engineering Research and Design (2024): https://doi.org/10.1016/j.cherd.2024.01.057. 10.1016/j.cherd.2024.01.057 Anabela Veiga; Sara Madureira; João B. Costa; Filipa Castro; Fernando Rocha; Ana L. Oliveira. "Tackling current production of HAp and HAp-driven biomaterials". Materials Advances (2023): https://doi.org/10.1039/D3MA00363A. 10.1039/D3MA00363A Joana Ferreira; Filipa Castro. "Advances in protein solubility and thermodynamics: quantification, instrumentation, and perspectives". CrystEngComm (2023): https://doi.org/10.1039/D3CE00757J. 10.1039/D3CE00757J Veiga, Anabela; Castro, Filipa; Ferreira, António; Oliveira, Ana L.; Rocha, Fernando. Corresponding author: Castro, Filipa. "Fabrication of calcium phosphates with controlled properties using a modular oscillatory flow reactor". Chemical Engineering Research and Design 183 (2022): 90-103. http://dx.doi.org/10.1016/j.cherd.2022.04.036. 10.1016/j.cherd.2022.04.036 Ferreira, Joana; Sárkány, Zsuzsa; Castro, Filipa; Rocha, Fernando; Kuhn, Simon. "Insulin crystallization: The route from hanging-drop vapour diffusion to controlled crystallization in droplet microfluidics". Journal of Crystal Growth 582 (2022): 126516. http://dx.doi.org/10.1016/j.jcrysgro.2022.126516. 10.1016/j.jcrysgro.2022.126516 Veiga, Anabela; Magalhães, Rui; Duarte, Marta M.; Dias, Juliana R.; Alves, Nuno M.; Costa-Pinto, Ana Rita; Castro, Filipa; Rocha, Fernando; Oliveira, Ana L.. Corresponding author: Castro, Filipa. "Continuous Production of Highly Tuned Silk/Calcium-Based Composites: Exploring New Pathways for Skin Regeneration". Molecules 27 7 (2022): 2249. http://dx.doi.org/10.3390/molecules27072249. 10.3390/molecules27072249 Filipa Castro; Inês Cunha; António Ferreira; José A. Teixeira; Fernando Rocha. Corresponding author: Filipa Castro. "Towards an enhanced control of protein crystallization: Seeded batch lysozyme crystallization in a meso oscillatory flow reactor". Chemical Engineering Research and Design 178 (2022): 575-582. https://doi.org/10.1016/j.cherd.2021.12.034. 10.1016/j.cherd.2021.12.034 Veiga, Anabela; Castro, Filipa; Rocha, Fernando; Oliveira, Ana L.. Corresponding author: Castro, Filipa. "An update on hydroxyapatite/collagen composites: What is there left to say about these bioinspired materials?". Journal of Biomedical Materials Research Part B: Applied Biomaterials (2021): http://dx.doi.org/10.1002/jbm.b.34976. 10.1002/jbm.b.34976 Ferreira, Joana; Opsteyn, Jeroen; Rocha, Fernando; Castro, Filipa; Kuhn, Simon. Corresponding author: Castro, Filipa. "Ultrasonic protein crystallization: Promoting nucleation in microdroplets through pulsed sonication". Chemical Engineering Research and Design 162 (2020): 249-257. http://dx.doi.org/10.1016/j.cherd.2020.08.014. 10.1016/j.cherd.2020.08.014 Veiga, Anabela; Castro, Filipa; Rocha, Fernando; Oliveira, Ana. "Silk-based microcarriers: current developments and future perspectives". IET Nanobiotechnology 14 8 (2020): 645-653. http://dx.doi.org/10.1049/iet-nbt.2020.0058. 10.1049/iet-nbt.2020.0058 Veiga, Anabela; Castro, Filipa; Oliveira, Ana; Rocha, Fernando. Corresponding author: Castro, Filipa. "High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites". Journal of Chemical Technology & Biotechnology 96 1 (2020): 241-248. http://dx.doi.org/10.1002/jctb.6532. 10.1002/jctb.6532 Veiga, Anabela; Castro, Filipa; Rocha, Fernando; Oliveira, Ana L.. Corresponding author: Castro, Filipa. "Protein-Based Hydroxyapatite Materials: Tuning Composition toward Biomedical Applications". ACS Applied Bio Materials 3 6 (2020): 3441-3455. http://dx.doi.org/10.1021/acsabm.0c00140. 10.1021/acsabm.0c00140 Veiga, Anabela; Castro, Filipa; Reis, Cassilda Cunha; Sousa, Aureliana; Oliveira, Ana L.; Rocha, Fernando. "Hydroxyapatite/sericin composites: A simple synthesis route under near-physiological conditions of temperature and pH and preliminary study of the effect of sericin on the biomineralization process". Materials Science and Engineering: C 108 (2020): 110400. http://dx.doi.org/10.1016/j.msec.2019.110400. 10.1016/j.msec.2019.110400 Veiga, Anabela; Castro, Filipa; Rocha, Fernando; Oliveira, Ana L.. Corresponding author: Castro, Filipa. "Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials". Frontiers in Materials 7 (2020): http://dx.doi.org/10.3389/fmats.2020.00024. 10.3389/fmats.2020.00024 Ferreira, Joana; Castro, Filipa; Kuhn, Simon; Rocha, Fernando. Corresponding author: Castro, Filipa. "Controlled protein crystal nucleation in microreactors: the effect of the droplet volume versus high supersaturation ratios". CrystEngComm 22 28 (2020): 4692-4701. http://dx.doi.org/10.1039/d0ce00517g. 10.1039/d0ce00517g Ferreira, J.; Castro, F.; Rocha, F.; Kuhn, S.. Corresponding author: Castro, F.. "Protein crystallization in a droplet-based microfluidic device: Hydrodynamic analysis and study of the phase behaviour". Chemical Engineering Science 191 (2018): 232-244. http://dx.doi.org/10.1016/j.ces.2018.06.066. 10.1016/j.ces.2018.06.066 Castro, Filipa; Ferreira, António; Teixeira, José A.; Rocha, Fernando. Corresponding author: Castro, Filipa. "Influence of Mixing Intensity on Lysozyme Crystallization in a Meso Oscillatory Flow Reactor". Crystal Growth & Design 18 10 (2018): 5940-5946. http://dx.doi.org/10.1021/acs.cgd.8b00721. 10.1021/acs.cgd.8b00721 Castro, Filipa; Ribeiro, Viviana P; Ferreira, António; Oliveira, Ana L; Reis, Rui L; Teixeira, José A; Rocha, Fernando. Corresponding author: Castro, Filipa. "Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite:in vitromineralization and biological evaluation". Materials Research Express 3 7 (2016): 075404. http://dx.doi.org/10.1088/2053-1591/3/7/075404. 10.1088/2053-1591/3/7/075404 Castro, Filipa; Ferreira, António; Teixeira, José A.; Rocha, Fernando. Corresponding author: Castro, Filipa. "Protein Crystallization As a Process Step in a Novel Meso Oscillatory Flow Reactor: Study of Lysozyme Phase Behavior". Crystal Growth & Design 16 7 (2016): 3748-3755. http://dx.doi.org/10.1021/acs.cgd.6b00262. 10.1021/acs.cgd.6b00262 Castro, Filipa; Kuhn, Simon; Jensen, Klavs; Ferreira, António; Rocha, Fernando; Vicente, António; Teixeira, José António. Corresponding author: Castro, Filipa. "Process intensification and optimization for hydroxyapatite nanoparticles production". Chemical Engineering Science 100 (2013): 352-359. http://dx.doi.org/10.1016/j.ces.2013.01.002. 10.1016/j.ces.2013.01.002 Castro, Filipa; Ferreira, António; Rocha, Fernando; Vicente, António; Teixeira, José António. Corresponding author: Castro, Filipa. "Precipitation of hydroxyapatite at 37 °C in a meso oscillatory flow reactor operated in batch at constant power density". AIChE Journal 59 12 (2013): 4483-4493. http://dx.doi.org/10.1002/aic.14193. 10.1002/aic.14193 Castro, Filipa; Ferreira, António; Rocha, Fernando; Vicente, António; Teixeira, José António. Corresponding author: Castro, Filipa. "Continuous-Flow Precipitation of Hydroxyapatite at 37 °C in a Meso Oscillatory Flow Reactor". Industrial & Engineering Chemistry Research 52 29 (2013): 9816-9821. http://dx.doi.org/10.1021/ie400710b. 10.1021/ie400710b Castro, Filipa; Kuhn, Simon; Jensen, Klavs; Ferreira, António; Rocha, Fernando; Vicente, António; Teixeira, José António. Corresponding author: Castro, Filipa. "Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems". Chemical Engineering Journal 215-216 (2013): 979-987. http://dx.doi.org/10.1016/j.cej.2012.11.014. 10.1016/j.cej.2012.11.014 Castro, F.; Ferreira, A.; Rocha, F.; Vicente, A.; António Teixeira, J.. Corresponding author: Castro, F.. "Characterization of intermediate stages in the precipitation of hydroxyapatite at 37°C". Chemical Engineering Science 77 (2012): 150-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862842513&partnerID=MN8TOARS. 10.1016/j.ces.2012.01.058
Thesis / Dissertation	Castro, Filipa. "Process Intensification for the production of hydroxyapatite nanoparticles". PhD, 2013. http://hdl.handle.net/1822/24359. Castro, Filipa. "Development of methodologies of characterization for complex cell structures: case of the yeast Saccharomyces cerevisiae.". Master, Universidade do Minho Centro de Engenharia Biológica, 2008.

Intellectual property

Patent

António Ferreira; Fernando Rocha; José António Teixeira; Castro, Filipa. 2022. "Modular Oscillatory Flow Plate Reactor". Portugal.
Ferreira, António; Rocha, Fernando; Teixeira, José António; Castro, Filipa. 2019. "Modular Oscillatory Flow Plate Reactor - US20190111402". United States.
Withdrawn
António Ferreira; Fernando Rocha; José António Teixeira; Castro, Filipa. 2018. "Modular Oscillatory Flow Plate Reactor". United States.
Pending

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2024/09/04	Gas-liquid mass transfer in an oscillatory flow fixed and fluidized bed reactor	16th International Conference on Gas-Liquid and Gas-Liquid-Solid Reactor Engineering - GLS-16 (Dresden, Germany)
2024/09/03	Continuous protein crystallization under oscillatory flow mixing	16th International Conference on Gas–Liquid and Gas–Liquid–Solid Reactor Engineering – GLS-16 (Dresden, Germany)
2024/07/22	Continuous protein crystallization under oscillatory flow mixing	8th European Conference on Crystal Growth – ECCG8 (Warsaw, Poland)
2023/09	Towards protein crystallization as a tool for bio-separation: study of insulin crystallization in a meso OFR-SPC	ISIC 2023 \| 22nd International Symposium on Industrial Crystallization (Glasgow, United Kingdom)
2023/09	Towards protein crystallization as a tool for bio-separation: Study of insulin crystallization in a meso OFR-SPC	ECCE 14 & ECAB 7 \| 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (Berlin, Germany)
2023/09	Investigation of insulin nucleation kinetics under oscillatory flow mixing	ChemPor2023 \| 14th International Chemical and Biological Conference Instituto Politécnico de Bragança (Bragança, Portugal)
2023/05/24	Protein crystallization in micro- and meso-scale devices	ISBC2023 \| 8th International School on Biological Crystallization (Granada, Spain)
2022/09/28	Crystallization of insulin in a meso oscillatory flow	BPP 2022 \| Biopartitioning & Purification Conference (Aveiro, Portugal)
2022/09	Reinventing calcium phosphates for skin tissue engineering: continuous manufacturing of tailored particles	Bioceramics 32 \| Symposium and Annual Meetings of the International Society for Ceramics in Medicine (Venice, Italy)
2022/09	New opportunities for Silk Sericin Gel Design and Sterilization	AERoGELS COST Action \| Training School on 3D Printing of Gels and Aerogels (Santiago de Compostela, Spain)
2022/07/26	Towards Protein Crystallization as a Bio-Separation Tool	ECCG7 \| 7th European Conference on Crystal Growth (Paris, France)
2021/10/26	A simple and controlled method for the continuous production of calcium/sericin-based composites	SEJIPOL2020-21 \| The 5th Young Polymer Scientists Seminar ICTP-CSIC (Madrid, Spain)
2021/08/04	Enhanced control of protein crystallization in droplet-based microfluidics	ACCGE-22/ OMVPE-20 \| The 22nd American Conference on Crystal Growth and Epitaxy and 20th U.S. Biennial Workshop on Organometallic Vapor Phase Epitaxy (United States)
2020/03/02	Silk-based microcarriers as an emerging technology in Biomedical Engineering	Annual Cycle of Seminars on Biomedical Engineering Escola Superior de Biotecnologia - Universidade Católica do Porto (Porto, Portugal) (Porto , Portugal)
2019/10/10	High efficient strategy for the production of hydroxyapatite / sericin nanocomposites	Workshop for Young Researchers in Ceramics and Glasses for Medical Applications Sociedad Española Cerámica Y Vidrio (Madrid, Spain)
2019/05/09	Synthesis and Characterization of Hydroxyapatite-based nanocomposites	Annual Cycle of Seminars on Biomedical Engineering Escola Superior de Biotecnologia - Universidade Católica do Porto (Porto, Portugal) (Porto, Portugal)
2018/10	Droplet microfluidic devices for protein crystallization	ICCBM17 \| 17th International Conference on the Crystallization of Biological Macromolecules (Shanghai , China)
2018/04	Effect of mixing intensity on lysozyme crystallization in a meso oscillatory flow reactor	AIChE Meeting WCPT8 \| 8th World Congress on Particle Technology (Orlando, United States)
2018/04	Hydrodynamics and mixing dynamics in droplet-based microfluidics for protein crystallization	AIChE Meeting WCPT8 \| 8th World Congress on Particle Technology (Orlando, United States)
2017/06	Synthesis of Hydroxyapatite/Sericin nanocomposites	DCE17 \| 2nd Doctoral Congress of Engineering Faculty of Engineering of the University of Porto (Porto, Portugal)
2016/08	Protein crystallization in a novel meso oscillatory flow reactor.	CHISA 2016 \| 22nd International Congress of Chemical and Process Engineering (Praga, Czech Republic)
2015	Continuous-flow precipitation as a route to prepare highly controlled nanohydroxyapatite	MicroBiotec’15 \| Congress of Microbiology and Biotechnology Universidade de Évora (Évora, Portugal)
2013/08	Process Intensification and Optimization for the Hydroxyapatite Nanoparticles Production	GLS-11 \| 11th Gas Liquid and Gas Liquid Solid Reactor Engineering Congress COEX (Seoul, South Korea)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/09 - Current	Cristalização seletiva de proteínas de soro de leite Supervisor	Mestrado em Bioquímica (Master) Universidade da Beira Interior, Portugal
2021/01/01 - 2024/06/07	Biofabrication of a 3D silk-sericin construct as a new strategy for Engineering a Skin Tissue Model Co-supervisor	Escola Superior de Biotecnologia da Universidade Católica Portuguesa, Portugal
2021/09 - 2022/09	Physical and Chemical Parameters Screening for Co-Crystallization of rS -COMT-entacapone Supervisor	Bioquímica (Master) Universidade da Beira Interior, Portugal
2022/03 - 2022/07	Batch insulin crystallization in an oscillatory flow reactor Supervisor	Bioengenharia (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2022/03 - 2022/07	Continuous synthesis of hydroxyapatite nanoparticles in a planar oscillatory flow reactor Co-supervisor	Bioengenharia (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2021/09/15 - 2021/12/15	Application of nucleation strategies and microfluidics devices to the crystallization of biomolecules Co-supervisor	Advanced Chemistry (Other) Universidad de Almería, Spain
2020 - 2021/01/22	Cristalização de Proteínas por Sementeira num Reator de Fluxo Oscilatório Supervisor	Ciências de Engenharia Química e Bioquímica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/09 - 2020/12/18	Droplet-based microreactor for protein crystallization Co-supervisor	Katholieke Universiteit Leuven_Arenberg Doctoral School, Belgium Universidade do Porto Faculdade de Engenharia, Portugal
2018/10 - 2019/02/21	Estudo comparativo da cristalização de lisozima num tanque agitado e num RFO-CSP Supervisor	Engenharia Química (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2017/09 - 2018/02	Synthesis of Hydroxyapatite and Sericin nanocomposites Co-supervisor	Bioengenharia (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2016 - 2017	Coating of glass slides to promote cell adhesion during staining procedures for cyto and histopathological exams Co-supervisor	Universidade do Porto Faculdade de Engenharia, Portugal
2015 - 2016	Screening and optimization of protein crystallization in a droplet-based multiphase microfluidics bioreactor Co-supervisor	Universidade do Minho, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/07/05 - 2021/07/09	EMERGENCE@U.PORTO - Digital Media Science Communication Hackathon Other	EMERGENCE@U.PORTO (Digital Media Science Communication Hackathon) Universidade do Porto, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2017/04/19	Calcium Phosphate Cements Reinforced with Polyvinyl Alcohol Fibers for Bone Load-Bearing Applications (Thesis) Arguer	Tomás Sobral Marques (Master) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Consulting

	Activity description	Institution / Organization
2024 - Current	Development of an experimental installation based on oscillatory flow reactors for protein crystallization in space for the company Bio-Orbit

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2025/02 - Current	Engenharia Enzimática	Engenharia Química e Biológica (Licenciatura)	Universidade do Minho, Portugal
2024/09 - Current	Introdução à Engenharia de Processos	Engenharia Química e Biológica (Licenciatura)	Universidade do Minho, Portugal

Distinctions

Award

2023	Scientific recognition Universidade do Porto Faculdade de Engenharia, Portugal

Other distinction

2008	Prémio Universidade do Minho Universidade do Minho, Portugal
2004	Prémio de Mérito Escolar Universidade do Minho, Portugal