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Ricardo Bastos Leite. Concluiu o(a) Doutoramento em Bioquímica em 2012 pelo(a) Universidade do Algarve Faculdade de Ciências e Tecnologia, Doutoramento em Ciências Biológicas em 2012 pelo(a) Universidade do Algarve, Licenciatura em Bioquímica em 2002 pelo(a) Universidade do Algarve e Master Universitario em Master Acuicultura y pescas em 2005 pelo(a) Universidad de Cádiz Facultad de Ciencias del Mar y Ambientales. É Investigador no(a) Instituto Gulbenkian de Ciência. Publicou 25 artigos em revistas especializadas. Possui 6 capítulo(s) de livros. Possui 4 patente(s) registada(s). No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Perkinsus olseni e perkinsose; Ameijoa Ruditapes decussatus; Endoperóxidos com atividade antiparasitária; Formação de alquilantes catalizada por Fe(II); Biossensores; Bioelectrónica; Transistors de efeito de campo; Medidas eléctricas; biologia de sistemas; robustez; reposicionamento de fármacos; doença infecciosa; Perkinsus atlanticus; Doenças em bivalves; Metabolismo; Expressão diferenciada; Biosensores; Biofísica; Bioelectronica; Electrodos extracelulares; .
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Identification

Personal identification

Full name
Ricardo Bastos Leite

Citation names

  • Leite, Ricardo B

Author identifiers

Ciência ID
F115-256E-C84D
ORCID iD
0000-0002-9622-3895
Google Scholar ID
zrpuoYwAAAAJ

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Advanced (C1) Advanced (C1) Upper intermediate (B2) Proficiency (C2) Upper intermediate (B2)
French Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2012
Concluded
 Ciências Biológicas (Doutoramento)
Major in Biologia Celular e Molecular
Universidade do Algarve, Portugal
2012
Concluded
 Bioquímica (Doutoramento)
Major in Especialidade: Biologia Celular e Molecular
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"EXPLORING AN UNCOMMON HOST-PARASITE INTERACTION TO UNVEIL THE UNIQUENESS OF PERKINSUS SP AS A MODEL ORGANISM" (THESIS/DISSERTATION)
2005
Concluded
 Master Acuicultura y pescas (Master Universitario)
Universidad de Cádiz Facultad de Ciencias del Mar y Ambientales, Spain
2002
Concluded
 Bioquímica (Licenciatura)
Universidade do Algarve, Portugal
Affiliation

Science

2019/01/01 - Current Researcher (Research)
Instituto Gulbenkian de Ciência, Portugal

Teaching in Higher Education

2018/04/01 - 2019/03/31 Invited Adjunct Teacher (Polytechnic Teacher)
Instituto Politécnico de Setúbal, Portugal
2014 - 2015 Invited Associate Professor (University Teacher)
Universidade do Algarve, Portugal
Projects

Grant

Designation Funders
2011 - 2014/06 Intelligent Cell Surfaces (ICS)
Provided by PTCRIS: 123624
123624
 Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2014/06 AQUATOX - Assessment of mineralogenic toxicity of aquatic pollutants
112992
Provided by PTCRIS: 112992
 Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2013/07 Development and characterization of zebrafish stem cells: implications for transgenesis - FishCell
Provided by PTCRIS: 105313
105313
 Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2011/10 Development of tools to analyse sperm quality in fish: implications for cryobanking- CRYOSPERM
64533
Provided by PTCRIS: 64533
 Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2010/07 Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets
72083
Provided by PTCRIS: 72083
 Fundação para a Ciência e a Tecnologia, I.P.
2005 - 2008/05 Characterisation of the folate and purine metabolism in the protozoan parasite Perkinsus atlanticus: identification of genes involved in these pathways and potential therapeuthic targets
57982
Provided by PTCRIS: 57982
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2016 - 2019/05/31 Controlo da perkinsose em amêijoas usando endoperóxidos análogos de Artemisinina
PTDC/MAR-BIO/4132/2014
Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2011 - 2015/03/31 Sensores inteligentes para monitorizar células biológicas
EuroBioSAS/0001/2010
Universidade do Algarve, Portugal

Universidade do Algarve Centro de Electronica Optoelectrônica e Telecomunicacoes, Portugal
Fundação para a Ciência e a Tecnologia
2012 - 2015/01/31 Loss of robustness as a drug targeting principle for drug repositioning
PTDC/EBB-BIO/119006/2010
Fundação Calouste Gulbenkian, Portugal
 Fundação para a Ciência e a Tecnologia
2005 - 2008/05/31 Caracterização dos metabolismos do ácido fólico e das purinas no protozoário parasita Perkinsus atlanticus: identificação dos genes envolvidos na sua biossintese e potenciais alvos terapêuticos
POCI/CVT/57982/2004
 Fundação para a Ciência e a Tecnologia
2000 - 2004/10/01 Transistores de efeito de campo para medir actividade eléctrica de células individuais em cultura.
POCTI/FIS/34668/2000
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Leite, Ricardo B. "Biotecnologia e síntese química ao serviço dos mariscadores". In A europa e o Mar: Inovação e investigação cientifica em Portugal. Faro, Portugal, 2016.
    Published
  2. Leite, Ricardo B. "Biodiversidade azul em Portugal". In Mar Português- conhecimento, valorização e desenvolvimento. Faro, Portugal: Universidade do Algarve, 2012.
    Published
  3. B., Ricardo; Afonso, Ricardo; Leonor, M.. "Herbicides and Protozoan Parasite Growth Control: Implications for New Drug Development". In Herbicides, Theory and Applications, 567-580. Croatia: InTech, 2011.
    Published • 10.5772/13345
  4. Cancela, M. Leonor; Bargelloni, Luca; Boudry, Pierre; Boulo, Viviane; Dias, Jorge; Huvet, Arnaud; Laizé, Vincent; et al. "Genomic Approaches in Aquaculture and Fisheries". In Introduction to Marine Genomics, 213-286. Springer Netherlands, 2010.
    Published • 10.1007/978-90-481-8639-6_7
  5. Leite, Ricardo B. "Bivalves-perkinsus spp interactions". In Workshop for the analysis of the impact of perkinsosis to the European Shellfish industry. Vigo: Xunta de Galicia, 2008.
    Published
  6. Leite, Ricardo B. "Host parasites of the genus Perkinsus". In Workshop for the analysis of the impact of Perkinsosis to the European Shellfish Industry. Vigo, Spain: Centro de Investigacións Mariñas, Consellería de Pesca e Asuntos Marítimos da Xunta de Galicia, 2008.
    Published
Conference paper
  1. Leite, Ricardo B. "15. Can post-thaw sperm quality affect progeny from European seabass?". 2012.
    10.1016/j.cryobiol.2012.07.016
  2. Gomes, H.L.; Leite, R.B.; Afonso, R.; Stallinga, P.; Cancela, M.L.. "A microelectrode impedance method to measure interaction of cells". 2004.
Journal article
  1. Catarina Churro; Ana P. Semedo-Aguiar; Alexandra D. Silva; Jose B. Pereira-Leal; Ricardo B. Leite. "A novel cyanobacterial geosmin producer, revising GeoA distribution and dispersion patterns in Bacteria". Scientific Reports 10 1 (2020): https://doi.org/10.1038/s41598-020-64774-y.
    10.1038/s41598-020-64774-y
  2. Vítor Borges; Joana Isidro; Helena Cortes-Martins; Sílvia Duarte; Luís Vieira; Ricardo Leite; Isabel Gordo; et al. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections (2020): https://doi.org/10.1080/22221751.2020.1844552.
    10.1080/22221751.2020.1844552
  3. Leite, Ricardo B. "Expression of four new ferritins from grooved carpet shell clam Ruditapes decussatus challenged with Perkinsus olseni and metals (Cd, Cu and Zn)". Aquatic Toxicology (2020): 105675-105675. http://dx.doi.org/10.1016/j.aquatox.2020.105675.
    10.1016/j.aquatox.2020.105675
  4. Wang, Xin; Wilson, Peter R.; Leite, Ricardo B.; Chen, Guiyou; Freitas, Helena; Asadi, Kamal; Smits, Edsger C. P.; Katsouras, Ilias; Rocha, Paulo R. F.. "An Energy Harvester for Low-Frequency Electrical Signals". Energy Technology (2020): 2000114. http://dx.doi.org/10.1002/ente.202000114.
    Published • 10.1002/ente.202000114
  5. Leite, Ricardo B; Churro, Catarina. "A novel cyanobacterial geosmin producer, revising GeoA distribution and dispersion patterns in Bacteria.". Scientific Reports (2020):
    Accepted
  6. de Sousa, A.G.G.; Tomasino, M.P.; Duarte, P.; Fernández-Méndez, M.; Assmy, P.; Ribeiro, H.; Surkont, J.; et al. "Diversity and Composition of Pelagic Prokaryotic and Protist Communities in a Thin Arctic Sea-Ice Regime". Microbial Ecology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059694131&partnerID=MN8TOARS.
    10.1007/s00248-018-01314-2
  7. Paulo R. F. Rocha; Alexandra D. Silva; Lia Godinho; Willem Dane; Pedro Estrela; Lode K. J. Vandamme; Jose B. Pereira-Leal; Dago M. de Leeuw; Ricardo B. Leite. "Collective electrical oscillations of a diatom population induced by dark stress". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-23928-9.
    10.1038/s41598-018-23928-9
  8. Leite, Ricardo. "Microbial Diversity and Toxin Risk in Tropical Freshwater Reservoirs of Cape Verde". Toxins (2018): http://www.mdpi.com/2072-6651/10/5/186.
    10.3390/toxins10050186
  9. Carlos Saavedra; Massimo Milan; Ricardo B. Leite; David Cordero; Tomaso Patarnello; M. Leonor Cancela; Luca Bargelloni. "A Microarray Study of Carpet-Shell Clam (Ruditapes decussatus) Shows Common and Organ-Specific Growth-Related Gene Expression Differences in Gills and Digestive Gland". Frontiers in Physiology 8 (2017): https://doi.org/10.3389%2Ffphys.2017.00943.
    10.3389/fphys.2017.00943
  10. Silva, I A L; Cox, C J; Leite, R B; Cancela, M L; Conceicao, N. "Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation.". Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 172-173 (2014): 9-20.
    10.1016/j.cbpb.2014.03.007
  11. Pacchiarini, T.; Cross, I.; Leite, R.B.; Gavaia, P.; Ortiz-Delgado, J.B.; Pousão-Ferreira, P.; Rebordinos, L.; Sarasquete, C.; Cabrita, E.. "Solea senegalensis vasa transcripts: Molecular characterisation, tissue distribution and developmental expression profiles". Reproduction, Fertility and Development 25 4 (2013): 646-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876545332&partnerID=MN8TOARS.
    10.1071/RD11240
  12. Leite, R.B.; Milan, M.; Coppe, A.; Bortoluzzi, S.; dos Anjos, A.; Reinhardt, R.; Saavedra, C.; et al. "MRNA-Seq and microarray development for the Grooved carpet shell clam, Ruditapes decussatus: A functional approach to unravel host -parasite interaction". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886388970&partnerID=MN8TOARS.
    10.1186/1471-2164-14-741
  13. Araujo, N.C.P.; Afonso, R.; Bringela, A.; Cancela, M.L.; Cristiano, M.L.S.; Leite, R.B.. "Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves". Parasitology International 62 6 (2013): 575-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885374871&partnerID=MN8TOARS.
    10.1016/j.parint.2013.06.010
  14. Rafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.. "Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata". Cellular and Molecular Life Sciences 69 3 (2012): 423-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856224817&partnerID=MN8TOARS.
    10.1007/s00018-011-0754-y
  15. Milan, M.; Coppe, A.; Reinhardt, R.; Cancela, L.M.; Leite, R.B.; Saavedra, C.; Ciofi, C.; et al. "Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: Genomic tools for environmental monitoring". BMC Genomics 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955810928&partnerID=MN8TOARS.
    10.1186/1471-2164-12-234
  16. Simão, M.F.; Leite, R.B.; Rocha, C.; Cancela, M.L.. "Changes in bioturbation of iron biogeochemistry and in molecular response of the clam ruditapes decussates upon perkinsus olseni infection". Archives of Environmental Contamination and Toxicology 59 3 (2010): 433-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957969737&partnerID=MN8TOARS.
    10.1007/s00244-010-9490-9
  17. Ascenso, R.M.T.; Leite, R.B.; Afonso, R.; Cancela, M.L.. "Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis". Journal of Fish Diseases 32 7 (2009): 633-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650803089&partnerID=MN8TOARS.
    10.1111/j.1365-2761.2009.01039.x
  18. Leite, R.B.; Brito, A.B.; Cancela, M.L.. "An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni". Protist 159 3 (2008): 355-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549106156&partnerID=MN8TOARS.
    10.1016/j.protis.2008.03.002
  19. Tanguy, A.; Bierne, N.; Saavedra, C.; Pina, B.; Bachère, E.; Kube, M.; Bazin, E.; et al. "Increasing genomic information in bivalves through new EST collections in four species: Development of new genetic markers for environmental studies and genome evolution". Gene 408 1-2 (2008): 27-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549048659&partnerID=MN8TOARS.
    10.1016/j.gene.2007.10.021
  20. Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Cancela, M.L.. "Effect of the herbicide Roundup® on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus". Bulletin of Environmental Contamination and Toxicology 80 6 (2008): 512-515. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249130791&partnerID=MN8TOARS.
    10.1007/s00128-008-9412-y
  21. Elandalloussi, L.M.; Rodrigues, P.M.; Afonso, R.; Leite, R.B.; Nunes, P.A.; Cancela, M.L.. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". Molecular and Biochemical Parasitology 142 1 (2005): 106-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-19344373699&partnerID=MN8TOARS.
    10.1016/j.molbiopara.2005.03.014
  22. Pinto, J.P.; Conceição, N.M.; Viegas, C.S.B.; Leite, R.B.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. "Identification of a new pebp2aA2 isoform from Zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". Journal of Bone and Mineral Research 20 8 (2005): 1440-1453. http://www.scopus.com/inward/record.url?eid=2-s2.0-22744449747&partnerID=MN8TOARS.
    10.1359/JBMR.050318
  23. Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Nunes, P.A.; Cancela, M.L.. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". Aquaculture 243 1-4 (2005): 9-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644265408&partnerID=MN8TOARS.
    10.1016/j.aquaculture.2004.09.038
  24. Leite, R.B.; Afonso, R.; Cancela, M.L.. "Perkinsus sp. infestation in carpet-shell clams, Ruditapes decussatus (L), along the Portuguese coast. Results from a 2-year survey". Aquaculture 240 1-4 (2004): 39-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-4744368358&partnerID=MN8TOARS.
    10.1016/j.aquaculture.2004.05.014
  25. Elandalloussi, L.M.; Leite, R.M.; Afonso, R.; Nunes, P.A.; Robledo, J.A.F.; Vasta, G.R.; Cancela, M.L.. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". Molecular and Cellular Probes 18 2 (2004): 89-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642502971&partnerID=MN8TOARS.
    10.1016/j.mcp.2003.09.008

Intellectual property

Patent
  1. Leite, Ricardo B. 2015. "Expression constructs comprising a Terebella lapidaria nucleic acid encoding a cellulase, host cells, and methods of making the cellulase". United States.
    Granted/Issued
  2. Leite, Ricardo B. 2015. "Polypeptides having cellulase activity and polynucleotides encoding same".
    Granted/Issued
  3. Leite, Ricardo B. 2012. "Dfpase enzymes from aplysia californica". United States.
    Granted/Issued
  4. Leite, Ricardo B. 2012. "Dfpase enzymes from octopus vulgaris". United States.

Other

Other output
  1. Ana Paula Semedo-Aguiar; Jose Bartholo Pereira-Leal; Ricardo Bastos Leite. 2018. Microbial diversity and toxin risk in tropical freshwater reservoirs of Cape Verde. https://doi.org/10.1101/266957.
    10.1101/266957