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Micael S. Silva is a Postdoctoral Researcher in Dr. Julien Orts' group at the Department of Pharmaceutical Sciences, University of Vienna. He was previously abroad in Dr. Rina Rosenzweig's group at the Weizmann Institute of Science. MS received a PhD in Molecular Biosciences in 2021 from NOVA University of Lisbon. MS graduated in Biochemistry B.Sc. (2013) and Bioorganic Chemistry M.Sc. (2015) by FCT-NOVA. He published three original research articles. Since his bachelor's degree, he has been obsessed with NMR spectroscopy and structural biology. The approach to data science from his PhD allows him to overcome problems with critical thinking. MS has been engaged in several organisations in academic and scientific societies. He organised more than five events, from local workshops to national meetings (biochemistry and biophysics national meeting); he is the founder of Young Portuguese Biophysicists - an affiliated group of the Portuguese Biophysics Society.
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Identification

Personal identification

Full name
Micael Simões Silva

Citation names

  • Silva, Micael
  • Silva, M.
  • Silva, M. S.
  • Silva, Micael S.

Author identifiers

Ciência ID
F113-373B-CB8E
ORCID iD
0000-0002-0103-4451
Google Scholar ID
alrVM10AAAAJ&hl
Researcher Id
J-2595-2014

Email addresses

  • micael.silva@univie.ac.at (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences - Physical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/01/01 - 2021/12/10
Concluded
 Molecular Biosciences (Doutoramento)
Major in Molecular Mechanisms of Biological Processes
Universidade Nova de Lisboa, Portugal
"NMR investigation of ion-pair modulation of protein structure and dynamics and its relation to protein stability" (THESIS/DISSERTATION)
 Unanimously Approved
2013/09/01 - 2015/09/01
Concluded
 Bioorganic Chemistry (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Design of Bio-inspired Ionic Liquids for protein stabilisation" (THESIS/DISSERTATION)
 17/20
2010/09/01 - 2013/09/01
Concluded
 Biochemistry (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Study of protein/Ionic Liquid Interactions by Saturation Transfer Difference (STD) – Nuclear Magnetic Resonance (NMR)" (THESIS/DISSERTATION)
 15/20
Affiliation

Science

Category
Host institution 		Employer
2024/06 - Current Postdoc (Research) Universität Wien Division of Pharmaceutical Chemistry, Austria
Universität Wien Division of Pharmaceutical Chemistry, Austria
2022/01/24 - 2024/03/24 Postdoc (Research) Weizmann Institute of Science, Israel
Weizmann Institute of Science, Israel
2017/01/01 - 2021/12/10 Researcher (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/09/01 - 2016/01/01 Contracted Researcher (Research) Associação para a Inovação e Desenvolvimento da FCT, Portugal

Other Careers

Category
Host institution 		Employer
2021/09/20 - 2021/12/31 Técnico Superior (Técnico Superior) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade do Porto, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
154717UID
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Alexandre, Daniela; Santos, Tiago; Lopes-Nunes, Jéssica; Miranda, André; Figueiredo, Joana; Silva, Micael; Mergny, Jean-Louis; Batista, Pedro V.; Cruz, Carla. "Stabilization of AT11-B1 aptamer by ligand binding". Paper presented in XVII Annual Symposium CICS-UBI 2022, 2022.
  2. Santos, Tiago; Silva, Micael; Imbert, Lionel; Salgado, Gilmar; Cabrita, Eurico J.; Cruz, Carla. "RNA G-quadruplex motifs in precursor microRNAs and their interaction with small molecules and nucleolin". Paper presented in Structural Biology Conference 2022, 2022.
  3. Alexandre, Daniela; Santos, Tiago; Lopes-Nunes, Jéssica; Miranda, André; Figueiredo, Joana; Silva, Micael; Mergny, Jean-Louis; Batista, Pedro V.; Cruz, Carla. "Structural characterization of a G-quadruplex aptamer and their ligands". Paper presented in 4th National Organic Chemistry Meeting, 7th National Medicinal Chemistry Meeting, 2022.
  4. Silva, Micael S.; Viegas, Aldino; Philip O'Toole; Figueiredo, Angelo M; Cabrita, Eurico J.. "Choline glutamate modulates protein folding and stability: an NMR view". Paper presented in 2020 CCPN Conference online, 2020.
  5. Silva, Micael S.; O'Toole, Philip; Viegas, Aldino; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Modulation of protein (de)stabilisation by ionic liquids: an NMR view". Paper presented in 21th ISMAR - 15th EUROMAR joint conference, 2019.
  6. Silva, Micael S.; Viegas, Aldino; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Atomistic picture of charged metabolite – protein interaction with repercussions on protein stabilization". Paper presented in 9th ITQB NOVA PhD Student’s Meeting, 2018.
  7. Silva, Micael S.; O’Toole, Philip; Viegas, Aldino; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Tuning protein stability with ionic liquids: investigation of destabilizing vs stabilizing effects". Paper presented in 28th ICMRBS - International Conference on Magnetic Resonance in Biological Systems, 2018.
  8. Silva, Micael S.; Viegas, Aldino; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Discriminating the effect of charged metabolite interactions on protein structure and stability". Paper presented in 6th International Iberian Biophysics Congress and X Ibero-American Congress of Biophysics, 2018.
  9. Silva, Micael S.; Viegas, Aldino; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Discerning the effect of charged metabolite interactions on proteins". Paper presented in VIII Ibero-American NMR Meeting, 2018.
  10. Silva, Micael S.; Félix, Sara S.; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Targeting charged side-chains residues as probes for unspecific interactions under macromolecular crowding conditions". Paper presented in EMBO Practical Course 2016 - Multidimensional NMR in Structural Biology, 2016.
  11. Silva, Micael S.; Félix, Sara S.; Figueiredo, Angelo M.; Cabrita, Eurico J.. "The importance of charged side-chains residues of proteins under biological conditions". Paper presented in VIII Biennial Meeting of the Nuclear Magnetic Resonance Group of the Spanish Royal Society of Chemistry / V Iberian NMR Meeting, 2016.
  12. Silva, Micael S.; Cabrita, Eurico J.; Figueiredo, Angelo M.. "Influence of charged crowder on protein stability". Paper presented in 1st Joint French-Portuguese NMR conference, 2016.
  13. Silva, Micael S.; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Influence of charged metabolites on protein stability under macromolecular crowding". Paper presented in 2nd Meeting COST Action CM1306 – Dynamics of Biomacromolecular Machines, 2016.
  14. Silva, Micael S.; Figueiredo, Angelo M.; Cabrita, Eurico J.. "Discerning the nature of imidazolium-based ionic liquids/ protein interactions and their repercussions in protein denaturation". Paper presented in VII Biennial Meeting of the Nuclear Magnetic Resonance Group of the Spanish Royal Society of Chemistry / IV Iberian NMR Meeting / VI Ibero-American NMR Meeting, 2014.
  15. Laia, R.; Silva, Micael S.; Freire, Filipe; Macedo, Anjos L.; Cabrita, Eurico J.; Dias, Jorge. "Key factor in Alzheimer’s disease: ß-amyloid and implication of fusion protein GB1". Paper presented in at VII ENEBIOQ - Biochemistry Students National Meeting, 2014.
  16. Figueiredo, Angelo M.; Sardinha, João; Silva, Micael S.; Cabrita, Eurico J.. "Exploring the limits of protein denaturation by designed solvents and osmolytes". Paper presented in 55th ENC - Experimental Nuclear Magnetic Resonance Conference, 2014.
Journal article
  1. Santos T.; Micael S. Silva; Lionel Imbert; Maria P. C. Campello; António Paulo; Samir Amrane; Gilmar F. Salgado; Carla Cruz; Eurico J Cabrita. "Structural Perspective into the Interaction of an Oncogenesis-Relevant pre-miRNA G-Quadruplex Ligand Carrier with the Protein Nucleolin". Chemistry – A European Journal (2023): http://dx.doi.org/10.1002/chem.202301181.
    10.1002/chem.202301181
  2. Filipe M. Sousa; Patrícia Pires; Andreia Barreto; Patrícia N. Refojo; Micael S. Silva; Pedro B. Fernandes; Ana P. Carapeto; et al. "Unveiling the membrane bound dihydroorotate: Quinone oxidoreductase from Staphylococcus aureus". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1864 2 (2023): 148948-148948. http://dx.doi.org/10.1016/j.bbabio.2022.148948.
    10.1016/j.bbabio.2022.148948
  3. "Stabilization of a DNA aptamer by ligand binding". Biochimie 200 (2022): 8-18. https://doi.org/10.1016/j.biochi.2022.05.002.
    10.1016/j.biochi.2022.05.002
  4. Faustino, André F.; Barbosa, Glauce M.; Silva, Micael; Castanho, Miguel A. R. B.; Da Poian, Andrea T.; Cabrita, Eurico J.; Santos, Nuno C.; Almeida, Fabio C. L.; Martins, Ivo C.. "Fast NMR method to probe solvent accessibility and disordered regions in proteins". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-018-37599-z.
    Published • 10.1038/s41598-018-37599-z
  5. Leisico, Francisco; V. Vieira, Diana; Figueiredo, Teresa A.; Silva, Micael; Cabrita, Eurico J.; Sobral, Rita G.; Ludovice, Ana Madalena; et al. "First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-22986-3.
    Published • 10.1038/s41598-018-22986-3
  6. Silva, Micael; Figueiredo, Angelo Miguel; Cabrita, Eurico J.. "Epitope mapping of imidazolium cations in ionic liquid–protein interactions unveils the balance between hydrophobicity and electrostatics towards protein destabilisation". Phys. Chem. Chem. Phys. 16 42 (2014): 23394-23403. http://dx.doi.org/10.1039/c4cp03534h.
    Published • 10.1039/c4cp03534h
Preprint
  1. Guy Zoltsman; Thi Lieu Dang; Miriam Kuchersky; Ofrah Faust; Micael S. Silva; Tal Ilani; Anne S. Wentink; Bernd Bukau; Rina Rosenzweig. "A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53". 2023. https://doi.org/10.1101/2023.11.28.568993.
    10.1101/2023.11.28.568993
Thesis / Dissertation
  1. "NMR investigation of ion-pair modulation of protein structure and dynamics and their relation to protein stability". PhD, Universidade Nova de Lisboa, 2021. http://hdl.handle.net/10362/130775.
  2. Silva, Micael. "Design of bio-inspired ionic liquids for protein stabilisation". Master, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2015. http://hdl.handle.net/10362/17071.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02 Understanding the effects of ionic liquids on protein stability 11th ITQB NOVA PhD Students' Meeting
ITQB NOVA (Oeiras, Portugal)
2020/07 Molecular understanding of protein stability in ionic liquids Bioseminars
UCIBIO (Caparica, Portugal)
2019/09 Protein (de)stabilisation in Ionic Liquids: a biophysical approach I NOVA Biophysica international conference
(Lisbon, Portugal)
2018/05 Ionic Liquids as tunable modulators for protein stability 6th Portuguese Young Chemists Meeting
(Setúbal, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2011 - 2019 EXPO-FCT/UNL, scientific experiments demonstrator (2011 - 2019)
Exhibition (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 1st Biophysics party (2017/07/06 - 2017/07/06)
Meeting (Member of the Organising Committee)
 Portuguese Biophysics Society, Portugal
2014 - 2014 JORTEC "Bioquímicos pelo Mundo" (2014/02/10 - 2014/02/10)
Conference (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2014 VII Biochemistry Students National Meeting (ENEBIOQ) (2014/04/11 - 2014/04/14)
Meeting (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2013 JORTEC “Bio&Chemistry Today” (2013/02/22 - 2013/02/22)
Conference (Member of the Organising Committee)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/12/07 - 2020/12/08 EUROMAR online meeting
Meeting
 EUROMAR online meeting
2020/01/22 - 2020/01/24 10th ITQB NOVA PhD Student’s Meeting
Meeting
 10th ITQB NOVA PhD Student’s Meeting
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/11/18 - 2019/11/20 1st Meeting COST Action 18132 “Functional Glyconanomaterials for the development of diagnostics and targeted therapeutic probes”
Meeting
 1st Meeting COST Action 18132 “Functional Glyconanomaterials for the development of diagnostics and targeted therapeutic probes”
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/07/26 - 2019/08/02 EMBO Practical Course – Structure, dynamics and function of biomacromolecules
Workshop
 EMBO Practical Course – Structure, dynamics and function of biomacromolecules
European Molecular Biology Organization, Germany
2018/05 - 2018/05 Data Processing Automation (Python)
Workshop
 Data Processing Automation (Python)
Universidade Nova de Lisboa, Portugal
2018/04/14 - 2018/04/16 COST Action CM1306 WG3 workshop “Emerging Magnetic Resonance Techniques to study dynamic molecular machines”
Workshop
 COST Action CM1306 WG3 workshop “Emerging Magnetic Resonance Techniques to study dynamic molecular machines”
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/05/02 - 2017/05/05 Research Skills Development
Workshop
 Research Skills Development
Universidade Nova de Lisboa, Portugal
2016/07/10 - 2016/07/15 EMBO Practical Course - Multidimensional NMR in Structural Biology
Workshop
 EMBO Practical Course - Multidimensional NMR in Structural Biology
European Molecular Biology Organization, Germany
2016/02/24 - 2016/02/26 2nd Meeting COST Action CM1306 “Dynamics of Biomacromolecular Machines”
Meeting
 2nd Meeting COST Action CM1306 “Dynamics of Biomacromolecular Machines”
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/06/15 - 2015/06/19 NMR-focus: NMR and Modelling Methods for Protein Interactions and Drug Design
Workshop
 NMR-focus: NMR and Modelling Methods for Protein Interactions and Drug Design
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013/02/11 - 2013/02/15 Hands on course: NMR in protein interactions studies
Workshop
 Hands on course: NMR in protein interactions studies
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/05/07 - 2012/05/07 JORTEC “(Re)Descobrir a Bioquímica”
Conference
 JORTEC “(Re)Descobrir a Bioquímica”
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/03/30 - 2012/04/02 V ENEBIOQ - Biochemistry Students National Meeting
Meeting
 V ENEBIOQ - Biochemistry Students National Meeting
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2018 - Current Portuguese Biochemical Society
Member
 Sociedade Portuguesa de Bioquímica, Portugal
2017/12 - Current Portuguese Young Biophysicists Portuguese Biophysics Society, Portugal
2014 - 2015 Chemistry Department Pedagogic Council
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014 Bioorganic Chemistry M. Sc. Pedagogic Committee
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013 Biochemistry B. Sc. Pedagogic Committee
Member
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2014/11 - 2014/12 Advisory Council - evaluation of 1 BSc. courses ("Biochemistry") and 1 MSc. course ("Biochemistry")
Evaluator
 Agência de Avaliação e Acreditação do Ensino Superior, Portugal

Mentoring / Tutoring

Topic Student name
2020/02 - 2020/06 Structural studies of a-Synuclein and N-acetylated a-Synuclein under the influence of common metabolites Fredi Brigham
2019/02 - 2019/06 Estudos estruturas da a-Sinucleina sob a influencia de metabolitos comuns Ana L. Dias
2018/02 - 2018/06 Characterization of crowding effects on protein structure and functionality Philip O’Toole
2016/09 - 2017/09 Development of in-cell NMR methodologies Cláudia Afonso
2016/02 - 2016/06 Estudos por RMN de interações entre aminoácidos carregos em condições de crowding macromolecular Sara S. Félix
Distinctions

Award

2019 EMBO Travel Stipend
European Molecular Biology Organization, Germany
2018 ISMAR Travel Stipend
International Society of Magnetic Resonance, Israel
2016 GERMN Travel Stipend
Grupo Especializado de Resonancia Magnética Nuclear (GERMN) de la RSEQ, Spain
2014 Poster Prize Award - VII ENEBIOQ
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 Innovation Prize Award - VII ENEBIOQ
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 GERMN Travel Stipend
Grupo Especializado de Resonancia Magnética Nuclear (GERMN) de la RSEQ, Spain
2010 Academic Merit Award (Local)
Escola Secundária de Pombal , Portugal

Other distinction

2016 PhD doctoral fellowship (PD/BD/128202/2016) under the Doctoral Programme in Molecular Biosciences
Fundação para a Ciência e a Tecnologia, Portugal