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Graduated in Biomedical Sciences in 2011 and awarded with MSc in Molecular Biology and Genetics in 2014 at Faculdade de Ciências, Universidade de Lisboa. In 2017, I started my PhD in the ProRegeM PhD programme (NOVA/UAlgarve) supervised by Prof. Conde at CEDOC, NMS/NOVA and by Prof. Paulo Matafome at iCBR, Faculty of Medicine of Coimbra, with the project entitled "Targeting the carotid bodies to treat obesity". During my PhD I traveled between Prof. Conde and Matafome labs, but I also went abroad for 4 months (2018) to the Faculty of Medicine of Valladolid (Spain) and in the last year of my PhD (2020), I was awarded with Albert Renold Travel Fellowship from the European Foundation for the Study of Diabetes to spend 6 months at l'Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, INSERM, France to perform work included in my PhD. Since I started my scientific journey, I published 16 papers, from which 13 were in the last 5 years, 2 as first author. Also, I am now preparing the publication of 2 papers as 1st author that include my PhD work. The recognition of my scientific track can be seen by the several awards (Best Poster Early Career Physiologists' Symposium, Best Poster SPCAL) and grants (AstraZeneca Innovate Competition; Albert Renold; Shirahata travel grant) received in these last years. Moreover, I act as a reviewer for several scientific journals. I also co-supervised 2 degree projects of Biochemistry students and I am involved in the organization of the International Society of Arterial Chemoreceptors (ISAC) XXI Meeting.
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Identification

Personal identification

Full name
Bernardete Sofia Freitas Melo

Citation names

  • Melo, Bernardete F.

Author identifiers

Ciência ID
F01C-821E-FA56
ORCID iD
0000-0002-5065-5385

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2021/12/20
Concluded
 Mecanismos de Doença e Medicina Regenerativa (associação) (Doutoramento)
Major in Sem especialidade
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Targeting the carotid bodies to treat obesity" (THESIS/DISSERTATION)
 Muito Bom com distinção e Louvor por unanimidade
2014/10/29
Concluded
 Biologia Molecular e Genética (Mestrado)
Major in Sem especialização
Universidade de Lisboa Faculdade de Ciências, Portugal
"Carotid sinus nerve resection: therapeutic tool for the treatment of type 2 diabetes" (THESIS/DISSERTATION)
2007 - 2011
Concluded
 Análises Clínicas e Saúde Pública (Licenciatura)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
"Caracterização da distribuição de factores de risco cardiovascular dos alunos da Escola Superior de Tecnologia da Saúde do Porto" (THESIS/DISSERTATION)
Affiliation

Other Careers

Category
Host institution 		Employer
2021/05/30 - 2022/02/28 Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Análises Clínicas e de Saúde Pública) Synlabhealth (Hospital da Luz), Portugal
Hospital da Luz Lisboa, Portugal

Others

Category
Host institution 		Employer
2014/11/01 - 2016/12 Research fellow at the project " Mapping carotid sinus nerve activity in diabetes rat models”, supported by GlaxoSmithKline Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2023/06/30 Rumo à medicina bioeletrónica como terapêutica para a diabetes tipo 2: neuromodulação do nervo do seio carotídeo em tempo real
EXPL/MED-NEU/0733/2021
Universidade Nova de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/01/01 - 2020/12/31 Targeting the carotid bodies to treat obesity
PD/BD/128336/2017
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2015/08/30 Caracterização da atividade eferente do sistema nervoso simpático na resistência à insulina induzida pelos corpos carotídeos
EXPL/NEU-SCC/2183/2013
Other
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto Politécnico de Leiria, Portugal

Instituto de Telecomunicações, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Dos Santos, Eliano; Sacramento, Joana F.; Melo, Bernardete F.; Conde, Sílvia V.. "Carotid Body Dysfunction in Diet-Induced Insulin Resistance Is Associated with Alterations in Its Morphology". In Advances in Experimental Medicine and Biology, 103-108. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-91137-3_13
  2. Sacramento, Joana F.; Melo, Bernardete F.; Conde, Sílvia V.. "Adenosine Mediates Hypercapnic Response in the Rat Carotid Body via A2A and A2B Receptors". In Advances in Experimental Medicine and Biology, 89-93. Springer International Publishing, 2018.
    10.1007/978-3-319-91137-3_11
Conference abstract
  1. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Carotid body modulation: a therapeutic approach to induce adipose tissue browning and ameliorate metabolism promoting weight loss.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD)., Barcelona, 2019.
    Published
  2. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Bilateral carotid sinus nerve resection decreases weight gain, body fat mass and obesity associated co-morbidities in rodents.". Paper presented in 26th European Congress on Obesity (ECO2019), Glasgow, 2019.
    Published
  3. Cátia Barra; Ana Costa; Gabriela Tavares; Daniela Marques; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Coimbra, 2019.
    Published
  4. Gabriela Tavares; Daniela Marques; Cátia Barra; Ana Costa; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signaling with Bromocriptine improves glucose and lipid metabolism in white and brown adipose tissue of an obese type 2 diabetic animal model.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Coimbra, 2019.
    Published
  5. Joana F. Sacramento; Melo, Bernardete F.; Cláudia S. Prego; Silvia V. Conde. "Long-term hypercaloric diet consumption exacerbates age-induced metabolic dysfunction: beneficial effects of CSN denervation.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD), Berlin, 2018.
    Published
  6. Inês B. Martins; Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Adenosine metabolism is deregulated in brown adipose tissue in diet-induced type 2 diabetes.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD), Berlin, 2018.
    Published
  7. Cláudia S. Prego; Melo, Bernardete F.; Joana F. Sacramento; Silvia V. Conde. "A ressecção do nervo do seio carotídeo diminuiu o ganho de peso, a massa gorda corporal e melhora as comorbilidades associadas à obesidade.". Paper presented in 14th Portuguese Congress of Diabetes, Albufeira, 2018.
    Published
  8. Inês B. Martins; Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "O metabolismo da adenosina no tecido adiposo castanho encontra-se desregulado em modelos animais de diabetes tipo 2 induzidos por dietas hipercalóricas.". Paper presented in 14th Portuguese Congress of Diabetes., Albufeira, 2018.
    Published
  9. Joana F. Sacramento; Daniel J. Chew; Melo, Bernardete F.; Matteo Donegá; Wesley Dopson; Maria P. Guarino; Alison Robinson; et al. "Modulação bioelectrónica da actividade do nervo do seio carotídeo: potencial terapêutica para diabetes tipo 2.". Paper presented in 14th Portuguese Congress of Diabetes, Albufeira, 2018.
    Published
  10. Melo, Bernardete F.; Cláudia S. Prego; Miguel C. Correia; Marlene D. Cabral; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid body denervation in obesity co-morbilities". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD)., Lisbon, 2018.
    Published
Conference poster
  1. Melo, Bernardete F.; Jesus Prieto-Lloret; Marlene D. Cabral; Inês B. Martins; Joana F. Sacramento; Silvia V. Conde. "Quais os agentes moleculares responsáveis pelo dano endotelial induzido por dietas hipercalóricas, na artéria pulmonar?". Paper presented in 16th Portuguese Congress on Diabetes, Vilamoura, Portugal, 2020.
  2. Joana F. Sacramento; Melo, Bernardete F.; Elena Olea; Ana Obeso; Asuncion Rocher; Tiago Rodrigues; Jesus Prieto-Lloret; et al. "A hiperinsulinémia contribui para o desenvolvimento da resistência à insulina na apneia obstrutiva do sono independentemente da obesidade.". Paper presented in 16th Portuguese Congress of Diabetes, 2020.
  3. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Carotid body modulation: a therapeutic approach to induce adipose tissue browning and ameliorate metabolism promoting weight loss.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD), 2019.
  4. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Carotid body modulation: a therapeutic target to produce adipose tissue browning and ameliorate metabolism promoting weight loss.". Paper presented in 26th European Congress on Obesity (ECO2019), 2019.
  5. Cátia Barra; Ana Costa; Gabriela Tavares; Daniela Marques; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  6. Gabriela Tavares; Daniela Marques; Cátia Barra; Ana Costa; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signaling with Bromocriptine improves glucose and lipid metabolism in white and brown adipose tissue of an obese type 2 diabetic animal model.". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  7. Joana F. Sacramento; Cláudia C. Batista; Melo, Bernardete F.; Cláudia S. Prego; Silvia V. Conde. "O consumo de dieta hipercalórica a longo prazo agrava a disfunção metabólica induzida pela idade: efeitos benéficos da ressecção do nervo do seio carotídeo.". Paper presented in 15th Portuguese Congress of Diabetes, 2019.
  8. Melo, Bernardete F.; Joana F. Sacramento; Cláudia S. Prego; Silvia V. Conde. "Long-term hypercaloric diet consumption exacerbates age-induced metabolic dysfunction: beneficial effects of CSN denervation". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD), 2018.
  9. Inês B. Martins; Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Adenosine metabolism is deregulated in brown adipose tissue in diet-induced type 2 diabetes.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD), 2018.
  10. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid sinus nerve resection on white adipose tissue metabolism". Paper presented in Europhysiology 2018 Congress, 2018.
  11. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid sinus nerve resection on white adipose tissue metabolism". Paper presented in Early Career Physiologists' Symposium, 2018.
  12. Cláudia S. Prego; Melo, Bernardete F.; Joana F. Sacramento; Silvia V. Conde. "Carotid sinus nerve resection reduces weight gain and improves metabolic function in high-fat animals via an increase in brown adipose tissue function and decrease in its inflammation". Paper presented in Europhysiology 2018 Congress, 2018.
  13. Melo, Bernardete F.; Joana F. Sacramento; Cláudia S. Prego; Maria J. Ribeiro; Inês B. Martins; Maria P. Guarino; Silvia V. Conde. "What is the most appropriate rat model to study type 2 diabetes?". Paper presented in IV Congress Portuguese Society of Sciences in Laboratory Animals (SPCAL), 2018.
  14. Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "Bilateral carotid sinus nerve resection decreases weight gain, body fat mass and obesity associated co-morbidities in rodents". Paper presented in XXV European Congress on Obesity (ECO2018). Vienna, Austria, 2018.
  15. Cláudia S. Prego; Melo, Bernardete F.; Joana F. Sacramento; Silvia V. Conde. "A ressecção do nervo do seio carotídeo diminuiu o ganho de peso, a massa gorda corporal e melhora as comorbilidades associadas à obesidade.". Paper presented in 14th Portuguese Congress of Diabetes. Albufeira, Portugal, 2018.
  16. Maria J. Ribeiro; Joana F. Sacramento; Melo, Bernardete F.; Maria P. Guarino; Silvia V. Conde. "Efeito da leptina na ventilação e pressão arterial em ratos submetidos a uma dieta hipercalórica.". Paper presented in 14th Portuguese Congress of Diabetes. Albufeira, Portugal, 2018.
  17. Melo, Bernardete F.; Cláudia S. Prego; Miguel C. Correia; Marlene D. Cabral; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid body denervation in obesity co-morbilities.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Lisbon, Portugal, 2017.
  18. Paulo Matafome; Daniela Marques; A. S. Santos; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; Raquel Seiça; Silvia V. Conde. "Bromocriptine changes adipocyte lipid metabolism improving insulin sensitivity in obese diabetic rats". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Lisbon, Portugal, 2017.
  19. Inês B. Martins; Maria J. Ribeiro; Melo, Bernardete F.; Tiago Rodrigues; Joana F. Sacramento; Raquel Seiça; Paulo Matafome; Silvia V. Conde. "Alterations in adenosine metabolism and adenosine receptor expression are associated with insulin resistance". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Lisbon, Portugal, 2017.
  20. Inês B. Martins; Jesus Prieto-Lloret; Bernardete F. Melo; Joana F. Sacramento; Silvia V. Conde. "Diabetes progression differently affects endothelial function in the aorta and pulmonary artery.". Paper presented in iMed Conference 8.0. Lisbon, Portugal, 2016.
    10.1109/cic.2005.1588045
  21. Melo, Bernardete F.; Jesus Prieto-Lloret; Joana F. Sacramento; Silvia V. Conde. "Effects of acute and chronic metformin administration on pulmonary artery endothelial function.". Paper presented in Joint Meeting of the American Physiological Society and The Physiological Society. Dublin, Ireland, 2016.
  22. Joana F. Sacramento; Melo, Bernardete F.; Tiago Rodrigues; Joana C. Coelho; Elena Olea; Maria J. Ribeiro; Maria P. Guarino; et al. "Carotid body transection restores glucose and lipid homeostasis in prediabetes animal models.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Munich, Germany, 2016.
  23. Joana F. Sacramento; Jesus Prieto-Lloret; Melo, Bernardete F.; Silvia V. Conde. "High fat diet increases basal carotid sinus nerve activity and the responsiveness to hypoxia.". Paper presented in Joint Meeting of the American Physiological Society and The Physiological Society. Dublin, Ireland, 2016.
  24. Silvia V. Conde; Joana F. Sacramento; Melo, Bernardete F.; Sonal Patel; Daniel J. Chew; Wesley Dopson; Victor Pikov; et al. "Electrical Neuromodulation of the Carotid Sinus Nerve as a Novel Therapeutic Approach for the Treatment of Type 2 Diabetes". Paper presented in American Diabetes Association 76th scientific sessions. New Orleans, LA, 2016.
  25. Melo, Bernardete F.; Joana C. Coelho; Tiago Rodrigues; Joana F. Sacramento; Maria J. Ribeiro; Maria P. Guarino; Raquel Seiça; Paulo Matafome; Silvia V. Conde. "Chronic caffeine intake restores insulin sensitivity in high-sucrose diet rats throught adaptations in adipose tissue.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Stochkolm, Sweeden., 2015.
  26. Melo, Bernardete F.; Tiago Rodrigues; Joana F. Sacramento; Paulo Matafome; Maria J. Ribeiro; Raquel Seiça; Maria P. Guarino; Silvia V. Conde. "Carotid sinus nerve resection avoids weight gain and reverses dyslipidemia in metabolic syndrome and prediabetes animal models.". Paper presented in Fundação Astrazeneca Innovate Competition, iMed Conference 6.0. Lisbon, 2014.
  27. Joana C. Coelho; Melo, Bernardete F.; Joana F. Sacramento; Maria P. Guarino; Silvia V. Conde. "Establishing the caffeine dose that chronically restores insulin sensitivity in animal model of prediabetes". Paper presented in Fundação Astrazeneca Innovate Competition, iMed conference 6.0. Lisbon, 2014.
  28. Joana F. Sacramento; Joana C. Coelho; Melo, Bernardete F.; Maria P. Guarino; Silvia V. Conde. "Assessment of caffeine dose and time of administration required for resetting of insulin sensitivity in high-sucrose rats.". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Vienna, Austria, 2014.
  29. Maria J. Ribeiro; Joana F. Sacramento; Sara Yubero; Melo, Bernardete F.; Ana Obeso; Constancio Gonzalez; Maria P. Guarino; Silvia V. Conde. "Disclosing acute caffeine action on insulin sensitivity: effects on skeletal muscle". Paper presented in Annual Meeting of the European Association for the Study of Diabetes (EASD). Vienna, Austria, 2014.
Journal article
  1. Melo, Bernardete F.; Joana F. Sacramento; Adriana M. Capucho; Dinis Sampaio-Pires; Cláudia S. Prego; Conde, Silvia V.. "Long-term hypercaloric diet consumption exacerbates age-induced dysmetabolism and carotid body dysfunction: beneficial effects of CSN denervation". Frontiers in Physiology (2022):
    Accepted
  2. Conde, Silvia V.; Sacramento, Joana F.; Melo, Bernardete F.; Fonseca-Pinto, Rui; Romero-Ortega, Mario I.; Guarino, Maria P.. "Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation". Frontiers in Neuroscience 15 (2022): http://dx.doi.org/10.3389/fnins.2021.725751.
    Published • 10.3389/fnins.2021.725751
  3. Soares, Nuno L.; Paiva, Inês; Bravo, Joana; Queiroga, Cláudia S. F.; Melo, Bernadete F.; Conde, Sílvia V.; Romão, Carlos C.; Summavielle, Teresa; Vieira, Helena L. A.. "Carbon Monoxide Modulation of Microglia-Neuron Communication: Anti-Neuroinflammatory and Neurotrophic Role". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02643-z.
    Published • 10.1007/s12035-021-02643-z
  4. Tavares, G.; Marques, D.; Barra, C.; Rosendo-Silva, D.; Costa, A.; Rodrigues, T.; Gasparini, P.; et al. "Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes". Molecular Metabolism 51 (2021): 101241. http://dx.doi.org/10.1016/j.molmet.2021.101241.
    Published • 10.1016/j.molmet.2021.101241
  5. Melo, Bernardete F.; Prieto-Lloret, Jesus; Cabral, Marlene D.; Martins, Fatima O.; Martins, Inês B.; Sacramento, Joana F.; Ruivo, Pedro; Carvalho, Tânia; Conde, Silvia. V. "Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery". Scientific Reports (2021):
    Accepted
  6. Martins, Fátima O.; Sacramento, Joana F.; Olea, Elena; Melo, Bernardete F.; Prieto-Lloret, Jesus; Obeso, Ana; Rocher, Asuncion; et al. "Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation". (2021): http://hdl.handle.net/10316/95659.
  7. Tavares, Gabriela; Martins, Fatima O.; Melo, Bernardete F.; Matafome, Paulo; Conde, Silvia V.. "Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insulin Signaling and Metabolic Function". (2021): http://hdl.handle.net/10362/127176.
    https://doi.org/10.3389/fphar.2021.713418
  8. Sacramento, Joana F.; Andrzejewski, Kryspin; Melo, Bernardete F.; Ribeiro, Maria J.; Obeso, Ana; Conde, Silvia V.. "Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes". International Journal of Molecular Sciences 21 15 (2020): 5545. http://dx.doi.org/10.3390/ijms21155545.
    Published • 10.3390/ijms21155545
  9. Sacramento, Joana F.; Olea, Elena; Ribeiro, Maria J.; Prieto-Lloret, Jesus; Melo, Bernardete F.; Gonzalez, Constancio; Martins, Fatima O.; Monteiro, Emilia C.; Conde, Silvia V.. "Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing". The Journal of Physiology 597 19 (2019): 4991-5008. http://dx.doi.org/10.1113/jp274179.
    Published • 10.1113/jp274179
  10. Melo, Bernardete F.; Sacramento, Joana F.; Ribeiro, Maria J.; Prego, Claudia S.; Correia, Miguel C.; Coelho, Joana C.; Cunha-Guimaraes, Joao P.; et al. "Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats". (2019): http://www.scopus.com/inward/record.url?scp=85067310280&partnerID=8YFLogxK.
    https://doi.org/10.3390/nu11061197
  11. Ribeiro, Maria J.; Sacramento, Joana F.; Gallego-Martin, Teresa; Olea, Elena; Melo, Bernardete F.; Guarino, Maria P.; Yubero, Sara; Obeso, Ana; Conde, Silvia V.. "High fat diet blunts the effects of leptin on ventilation and on carotid body activity". The Journal of Physiology 596 15 (2018): 3187-3199. http://dx.doi.org/10.1113/jp275362.
    10.1113/jp275362
  12. Sacramento, Joana F.; Chew, Daniel J.; Melo, Bernardete F.; Donegá, Matteo; Dopson, Wesley; Guarino, Maria P.; Robinson, Alison; et al. "Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes". Diabetologia 61 3 (2018): 700-710. http://dx.doi.org/10.1007/s00125-017-4533-7.
    10.1007/s00125-017-4533-7
  13. Sacramento, Joana F.; Ribeiro, Maria J.; Rodrigues, Tiago; Olea, Elena; Melo, Bernardete F.; Guarino, Maria P.; Fonseca-Pinto, Rui; et al. "Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver". Diabetologia 60 1 (2016): 158-168. http://dx.doi.org/10.1007/s00125-016-4133-y.
    10.1007/s00125-016-4133-y
  14. Conde, Silvia V.; Ribeiro, Maria J.; Melo, Bernardete F.; Guarino, Maria P.; Sacramento, Joana F.. "Insulin resistance: a new consequence of altered carotid body chemoreflex?". The Journal of Physiology 595 1 (2016): 31-41. http://dx.doi.org/10.1113/jp271684.
    10.1113/jp271684
  15. Sacramento JF; Ribeiro MJ; Yubero S; Melo BF; Obeso A; Guarino MP; Gonzalez C; Conde SV. "Disclosing caffeine action on insulin sensitivity: Effects on rat skeletal muscle.". (2015): http://europepmc.org/abstract/med/25661425.
    10.1016/j.ejps.2015.01.011
Thesis / Dissertation
  1. Melo, Bernardete Sofia de Freitas, 1988-. "Carotid sinus nerve resection: therapeutic tool for the treatment of type 2 diabetes". Master, 2014. http://hdl.handle.net/10451/15707.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/02/10 Carotid body: a new player in the neural sympathetic circuits controlling the adipose tissue SPF Meeting 2022
(Porto, Portugal)
2021/07 Carotid body modulation decreases weight gain and improves metabolic function in the rat by impacting feeding behaviour and hypothalamic satiety pathways. Physiology 2021 Annual Conference
2020 Hyperinsulinemia is a major contributor to insulin resistance in chronic intermittent hypoxia, independently of obesity. Seizième Colloque Scientifique Étudiant de la Société Legallois Pour L’Étude du Contrôle Respiratoire
(Oxford, Canada)
2020 Carotid sinus nerve resection improves weight gain and glucose homeostasis through amelioration of adipose tissue function in mice: is there a role for b2-adrenergic signaling? L Annual Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2019/05 The beneficial effects of carotid sinus nerve resection on obesity and glucose homeostasis are related with adipose tissue browning. 7th Meeting of the EASD-EGIR Study Group
EASD-EGIR Study Group (Lisboa, Portugal)
2019/03 Os efeitos benéficos da desnervação do nervo do seio carotídeo na obesidade e na homeostasia da glucose devem-se à indução do browning do tecido adiposo. 15th Portuguese Congress of Diabetes
2019 Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity. European Respiratory Society (ERS) International Congress
(Madrid, Spain)
2019 Carotid sinus nerve improves hepatic function profile in young and old animals with metabolic dysfunctions exacerbated by long-term hypercaloric diet consumption. Physiology 2019
(Aberdeen, United Kingdom)
2019 Adjustments in purinergic metabolismo maintain the contribituion of adenosine and ATP to carotid body chemosensory activity in ageing. Physiology 2019
(Aberdeen, United Kingdom)
2018/10 Carotid body modulation to treat obesity: inducing adipose tissue browning. 22th Portuguese Congress of Obesity
(Portugal)
2018/03 Modulação bioelectrónica da actividade do nervo do seio carotídeo: potencial terapêutica para diabetes tipo 2. 14th Portuguese Congress of diabetes
(Portugal)
2018/03 O metabolismo da adenosina no tecido adiposo castanho encontra-se desregulado em modelos animais de diabetes tipo 2 induzidos por dietas hipercalóricas 14th Portuguese Congress of Diabetes
(Portugal)
2018/02 Carotid sinus nerve resection ameliorates glucose homeostasis and insulin secretion and action in an animal model of obesity. XLVIII Annual meeting of the Portuguese Society of Pharmacology,
(Portugal)
2018/02 Bilateral carotid sinus nerve resection decreases weight gain and body fat mass in a rat model of obesity. XLVIII Annual meeting of the Portuguese Society of Pharmacology
(Portugal)
2018/02 Adenosine metabolism is desregulated in brown adipose tissue in diet-induced type 2 diabetes: effect of carotid sinus nerve resection. XLVIII Annual meeting of the Portuguese Society of Pharmacology
(Portugal)
2018/02 Leptin effects on ventilation and on carotid body activity are blunted in high fat Wistar ats. XLVIII Annual meeting of the Portuguese Society of Pharmacology
(Portugal)
2018 Bioelectronic neuromodulation of the carotid sinus nerve as a potential therapeutic for type 2 diabetes. I NoTeS Congress – Novel Therapeutic Strategies for Noncommunicable Diseases
(Porto, Portugal)
2017/02 Effect of high-fat diet on carotid sinus nerve activity in basal conditions and in response to hypoxia. XLVII Annual meeting of the Portuguese Society of Pharmacology
(Portugal)
2017 Carotid Sinus Nerve resection decreases weight gain and fat mass in a rodent model of obesity XX Meeting of the International Society for Arterial Chemoreception
International Society for Arterial Chemoreception (Baltimore, United States)
2017 Effect of high-fat diet on carotid sinus nerve activity in basal conditions and in response to hypoxia. XLVII Annual meeting of the Portuguese Society of Pharmacology; Coimbra, Portugal.
2017 Small vessels endothelial function and diabetes onset XLVII Annual meeting of the Portuguese Society of Pharmacology; Coimbra, Portugal.
2016 Efeito da ressecção do nervo do seio carotídeo no transporte de glucose em modelos animais de resistência à insulina 12nd Portuguese Congress of Diabetes. Vilamoura, Portugal.
2016 Diabetes progression differently affects endothelial function in the aorta and pulmonary artery iMed Conference 8.0. Lisbon, Portugal.
2016 Chronic caffeine intake restores insulin sensitivity in high-sucrose diet rats throught adaptations in adipose tissue. XLVI Annual meeting of the Portuguese Society of Pharmacology. Porto, Portugal.
2016 Is the effect of carotid sinus nerve resection on insulin sensitivity mediated by na increase in glucose uptake? XLVI Annual meeting of the Portuguese Society of Pharmacology. Porto, Portugal.
2016 Changes in Adenosine/NO signaling pathway are associated with skeletal muscle and liver insulin resistance. XLVI Annual meeting of the Portuguese Society of Pharmacology. Porto, Portugal.
2016 Nitric Oxide and endotelial function in Metformin-treated diabetic rats. XLVI Annual meeting of the Portuguese Society of Pharmacology. Porto, Portugal.
2016 Alterations in Adenosine metabolism and Adenosine receptors expression are associated with insulin resistance. XLVI Annual meeting of the Portuguese Society of Pharmacology. Porto, Portugal.
2015 Alterations in adenosine receptor expression in skeletal muscle mediate the prevention of insulin resistance induced by adenosine antagonists in high sucrose diet animals. XLV Annual meeting of the Portuguese Society of Pharmacology. Lisbon, Portugal.
2014 Carotid sinus nerve resection avoids weight gain and reverses dyslipidemia in metabolic syndrome and prediabetes animal models. Fundação Astrazeneca Innovate Competition, iMed Conference 6.0. Lisbon, Portugal
2014 Establishing the caffeine dose that chronically restores insulin sensitivity in animal model of prediabetes. Fundação Astrazeneca Innovate Competition, iMed conference 6.0. Lisbon, Portugal.
2014 Effect of carotid sinus nerve denervation on body weight, total fat, visceral fat and lipid profile in diet-induced insulin resistance and hypertensive rats. XLIV Annual meeting of the Portuguese Society of Pharmacology. Coimbra, Portugal.

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - 2020 Disclosing pathophysiological mechanisms for chronic otitis media with efusion
Co-supervisor
 Bioquímica (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2019 Modulação da atividade do corpo carotídeo para o tratamento da obesidade
Co-supervisor
 Bioquímica (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/06/27 - 2022/06/30 Organizing member of International Society of Arterial Chemoreceptors (ISAC) XXI Meeting (2022/06/27 - 2022/06/30)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018 - 2018 1st FLxFlow Course - Principles and Applications of Flow Cytometry
Workshop
2017 - 2017 Research Skills Development at NOVA Doctoral School
Workshop
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2016 Optimising Surgical Techniques and Periopertaive Care in Rodents - 3 Day workshop
Workshop
Newcastle University, United Kingdom
2016 - 2016 Laboratory Animal Science practical course (FELASA Category B)
Other
Fundação Champalimaud, Portugal

SPCAL - Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal

Association member

Society Organization name Role
2018 - Current European Association for the Study of Diabetes
2017 - Current Sociedade Portuguesa de Farmacologia
2016 - Current Sociedade Portuguesa de Diabetologia

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - 2020 Practical course - 7th Edition of the Postgraduate Course on Animal Experimentation (Pós-Graduação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Journal of Food Biochemistry (1745-4514) Wiley (Blackwell Publishing)
2020 - Current Biomedicines (2227-9059) MDPI AG
Distinctions

Award

2018 Best poster communication at the Early Career Physiologists' Symposium
The Physiological Society, United Kingdom
2018 Best poster communication at the IV SPCAL Congress
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2017 Dr. Machiko Shirahata Trainee Award
International Society of Arterial Chemoreception, United States
2016 Prémio Professor Manuel Hargreaves SPD/NOVARTIS 2016
2016 Bolsa Charneco da Costa
Sociedade Portuguesa de Diabetologia, Portugal
2014 Fundação AstraZeneca Innovate Competition in the Translational Research category

Other distinction

2020 EFSD Albert Renold Travel Fellowship Programme
European Foundation for the Study of Diabetes, Germany
2019 EASD Travel grant for participation at the 55th EASD Annual Meeting, Barcelona (Spain)
European Association for the Study of Diabetes, Germany
2019 Bolsa SPD/Lilly EASD 2019
Sociedade Portuguesa de Diabetologia, Portugal
2019 EASO Travel grant for participation at the ECO2019 Congress, Glasgow (Scotland)
European Association for the Study of Obesity, United Kingdom
2018 Travel grant for participation at the Europhysiology 2018 Congress, London (UK)
The Physiological Society, United Kingdom
2018 EASO Travel grant for participation at the ECO2018 Congress, Vienna (Austria).
European Association for the Study of Obesity, United Kingdom
2016 Travel grant for participation at the Europhysiology 2016 Congress, Dublin (Ireland)
The Physiological Society, United Kingdom
2015 Scholarship for participation in the 3rd DZD Diabetes Research School