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Patricia Meireles. Conclui o Doutoramento em Ciências Biomédicas (Especialidade de Microbiologia e Parasitologia) em 2016 pela Universidade de Lisboa Faculdade de Medicina, no Instituto de Medicina Molecular João Lobo Antunes. Antes tinha finalizado a Licenciatura e de seguida o Mestrado em Bioquimica pela Faculdade de Ciências e Universidade do Porto. Realizei o meu trabalho de mestrado na IBPC, na Universidade de Paris, França. Atuo na área de Ciências Médicas e da Saúde com ênfase na biologia do parasita da malária, Plasmodium, e a resposta imune despoletada por este parasita.
Identification

Personal identification

Full name
Patricia Meireles

Citation names

  • Meireles, Patricia

Author identifiers

Ciência ID
F01B-91DA-7C52
ORCID iD
0000-0002-9188-2808

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016
Concluded
 Doutoramento em Ciências Biomédicas, especialidade de Microbiologia e Parasitologia (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"Nutrient uptake and metabolism in Plasmodium-infected hepatic cells" (THESIS/DISSERTATION)
 Aprovado por unanimidade com distinção
2010
Concluded
 Mestrado em Bioquimica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Role of the protein Myrip on secretory vesicle recruitment to the plasma membrane" (THESIS/DISSERTATION)
 18
2008
Concluded
 Licenciatura em Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Estudo da resposta imune induzida em murganhos infectados experimentalmente com estirpes de Candida albicans deficientes na produção de proteases aspárticas secretadas" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2019/01/21 - 2019/12/31 Contracted Researcher (Research) GlaxoSmithKline España, Spain
2016/05/10 - 2019/01/15 Postdoc (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2008/02/01 - 2008/07/01 Research Trainee (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Others

Category
Host institution 		Employer
2020/01 - 2022/02 Contrato Open Lab Foundation Instituto de Medicina Molecular João Lobo Antunes, Portugal
GlaxoSmithKline España, Spain
2011/04/01 - 2016/05/09 PhD Student Instituto de Medicina Molecular João Lobo Antunes, Portugal
2009/09/01 - 2010/10/01 Master Thesis Institut de Biologie Physico-Chimique, France
Projects

Grant

Designation Funders
2011/04 - 2015/03 Nutrient Uptake and Metabolism in Plasmodium-infected hepatic cells.
SFRH/BD/71098/2010
 Fundação para a Ciencia e Tecnologia (FCT)

Contract

Designation Funders
2016/08/01 - 2019/01/15 Improving whole-organism vaccines against malaria by genetic modification
PTDC/BBBBMD/2695/2014
Post-doc Fellow
Concluded
2012/01/01 - 2015/06 Utilização dos recursos da célula hospedeira pelo parasita da malária no fígado
PTDC/SAU-MIC/117060/2010
PhD Student Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal
Concluded
Outputs

Publications

Conference poster
  1. Meireles, Patricia. "Nutritional Supplementation Enhances Innate Immune Response Against Plasmodium Liver-stage Parasites". Paper presented in 29th Annual Molecular Parasitology Meeting, 9-13 September 2018, Marine Biological Laboratory, Woods Hole, MA, USA, 2018.
  2. Meireles, Patricia. "Innate immune response against Plasmodium liver-stage parasites is enhanced by targeted nutritional supplementation". Paper presented in 2nd Innate Immunity in Host-Pathogen Interactions, 24-27 June 2018, EMBL Advanced Training Centre, Heidelberg, Germany, 2018.
  3. Meireles, Patricia. "Mechanisms of inhibition of Plasmodium infection by targeted nutritional supplementation". Paper presented in TwinnToInfect Spring School on Infection and Immunity, 19-22 March 2018, Sesimbra, Portugal, 2018.
  4. Meireles, Patricia. "Inhibition of Plasmodium liver infection by amino acid supplementation and modulation of polyamine synthesis". Paper presented in 1st Lisbon Immunology & Infection Meeting (LIIM), 26 March 2015, Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal, 2015.
  5. Meireles, Patricia. "The role of D-glucose uptake by Glucose Transporter 1 during the liver stage of Plasmodium infection". Paper presented in 10th Annual BioMalPar/EVIMalaR Conference, 12-15 May 2014, EMBL Advanced Training Centre, Heidelberg, Germany, 2014.
Journal article
  1. Meireles, Patrícia; Brás, Daniela; Fontinha, Diana; Chora, Ângelo F.; Serre, Karine; Mendes, António M.; Prudêncio, Miguel. "Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation". iScience 23 12 (2020): 101781. http://dx.doi.org/10.1016/j.isci.2020.101781.
    Published • 10.1016/j.isci.2020.101781
  2. Meireles, Patrícia; Mendes, António M.; Aroeira, Rita I.; Mounce, Bryan C.; Vignuzzi, Marco; Staines, Henry M.; Prudêncio, Miguel. "Uptake and metabolism of arginine impact Plasmodium development in the liver". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/s41598-017-04424-y.
    10.1038/s41598-017-04424-y
  3. Mendes, António M.; Albuquerque, Inês S.; Machado, Marta; Pissarra, Joana; Meireles, Patrícia; Prudêncio, Miguel. "Inhibition of Plasmodium Liver Infection by Ivermectin". Antimicrobial Agents and Chemotherapy 61 2 (2016): http://dx.doi.org/10.1128/aac.02005-16.
    10.1128/aac.02005-16
  4. Ruivo, Margarida T. Grilo; Vera, Iset Medina; Sales-Dias, Joana; Meireles, Patrícia; Gural, Nil; Bhatia, Sangeeta N.; Mota, Maria M.; Mancio-Silva, Liliana. "Host AMPK Is a Modulator of Plasmodium Liver Infection". Cell Reports 16 10 (2016): 2539-2545. http://dx.doi.org/10.1016/j.celrep.2016.08.001.
    10.1016/j.celrep.2016.08.001
  5. Meireles, Patrícia; Sales-Dias, Joana; Andrade, Carolina M.; Mello-Vieira, João; Mancio-Silva, Liliana; Simas, J. Pedro; Staines, Henry M.; Prudêncio, Miguel. "GLUT1-mediated glucose uptake plays a crucial role duringPlasmodiumhepatic infection". Cellular Microbiology 19 2 (2016): e12646. http://dx.doi.org/10.1111/cmi.12646.
    10.1111/cmi.12646
  6. Liehl, Peter; Meireles, Patrícia; Albuquerque, Inês S.; Pinkevych, Mykola; Baptista, Fernanda; Mota, Maria M.; Davenport, Miles P.; Prudêncio, Miguel. "Innate Immunity Induced by Plasmodium Liver Infection Inhibits Malaria Reinfections". Infection and Immunity 83 3 (2015): 1172-1180. http://dx.doi.org/10.1128/iai.02796-14.
    10.1128/iai.02796-14
  7. Oliveira, Rudi; Guedes, Rita C.; Meireles, Patrícia; Albuquerque, Inês S.; Gonçalves, Lídia M.; Pires, Elisabete; Bronze, Maria Rosário; et al. "Tetraoxane–Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials". Journal of Medicinal Chemistry 57 11 (2014): 4916-4923. http://dx.doi.org/10.1021/jm5004528.
    10.1021/jm5004528
  8. Miranda, Daniela; Capela, Rita; Albuquerque, Inês S.; Meireles, Patrícia; Paiva, Isa; Nogueira, Fátima; Amewu, Richard; et al. "Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities". ACS Medicinal Chemistry Letters 5 2 (2013): 108-112. http://dx.doi.org/10.1021/ml4002985.
    10.1021/ml4002985
  9. Lin, Jing-wen; Meireles, Patrícia; Prudêncio, Miguel; Engelmann, Sabine; Annoura, Takeshi; Sajid, Mohammed; Chevalley-Maurel, Séverine; et al. "Loss-of-function analyses defines vital and redundant functions of thePlasmodiumrhomboid protease family". Molecular Microbiology 88 2 (2013): 318-338. http://dx.doi.org/10.1111/mmi.12187.
    10.1111/mmi.12187
  10. Huet, S.; Fanget, I.; Jouannot, O.; Meireles, P.; Zeiske, T.; Larochette, N.; Darchen, F.; Desnos, C.. "Myrip Couples the Capture of Secretory Granules by the Actin-Rich Cell Cortex and Their Attachment to the Plasma Membrane". Journal of Neuroscience 32 7 (2012): 2564-2577. http://dx.doi.org/10.1523/jneurosci.2724-11.2012.
    10.1523/jneurosci.2724-11.2012
Thesis / Dissertation
  1. BRÁS, Daniela Cristina de Henriques. "Mechanisms of inhibition of Plasmodium liver infection by amino acid supplementation". Master, 2018. http://hdl.handle.net/10362/52857.
  2. Meireles, Patrícia dos Santos, 1987-. "Nutrient uptake and metabolism in plasmodium-infected hepatic cells". PhD, 2016. http://hdl.handle.net/10451/28899.
  3. Meireles, Patricia. "Role of the protein Myrip on secretory vesicle recruitment to the plasma membrane". Master, Universidade do Porto Faculdade de Ciências, 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2017/11/22 Mechanisms of inhibition of Plasmodium infection by targeted nutritional supplementation Career Opportunities for PostDoctoral Researchers in Life Sciences Symposium
Post-doctoral Association Instituto Medicina Molecular João Lobo Antunes (Cascais, Portugal)
2017/01/17 Mechanisms of inhibition of Plasmodium infection by targeted nutritional supplementation iMM Post-Doc Day
Instituto de Medicinia Molecular (Lisboa, Portugal)
2015/05/11 Inhibition of Plasmodium liver infection by amino acid supplementation and modulation of polyamine synthesis 11th Annual BioMalPar/EVIMalaR Conference
EMBL (Heidelberg, Germany)
2015/03/26 The role of L-arginine uptake and polyamine production during liver stage infection by the malaria parasite. IX PhD Students Meeting iMM/CAML
Instituto de Medicina Molecular (Lisboa, Portugal)
2013/12/05 The role of D-glucose uptake by glucose transporter 1 during the liver stage of Plasmodium infection VII PhD Students Meeting iMM/CAML
Instituto de Medicina Molecular João Lobo Antunes (Lisba, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017/09 - 2018/09 Mechanisms of inhibition of Plasmodium liver infection by amino acid supplementation
Supervisor
 Ciências Biomédicas (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Distinctions

Award

2019 Global Employee Recognition, Innovation – Bronze Prize
GlaxoSmithkline Investigación y Desarrollo, Spain
2015 Best Student Oral Presentation
2012 Best Poster Presentation