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Chantal Fernandes, researcher at the Medical Microbiology research group (PI: Prof. Teresa Gonçalves) from the Center for Neuroscience and Cell Biology and FMUC, is developing work centered in the characterization of the fungal cell wall structure, namely on the study of the modulation of these cell components in response to antifungals, on their contribution for virulence and on their allergic potential. C Fernandes is also working on the identification and characterization of the antimicrobial activity of natural resources. C Fernandes is co-author in 14 publications, of these, 6 as first author and 2 as corresponding author. She has over 200 citations.
Identification

Personal identification

Full name
Chantal Ana Vicência Fernandes

Citation names

  • Fernandes, Chantal

Author identifiers

Ciência ID
EF1D-EE6A-2606
ORCID iD
0000-0001-7865-9946

Knowledge fields

  • Natural sciences - Biological Sciences - Mycology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2009
Concluded
Bioquímica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Osmotic and Thermal Adaptation in Ancient Thermophilic Bacteria: Biosynthesis of Glucosylglycerate and Mannosylglucosylglycerate " (THESIS/DISSERTATION)
Distinção e Louvor
2004
Concluded
Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Caracterização de uma B-proteobacteria: Herminiimonas fonticola isolada de uma fonte de água mineral " (THESIS/DISSERTATION)
16
Affiliation

Science

2019/01/04 - Current Contracted Researcher (Research)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

2010/06/01 - 2019/01/03 Postdoctoral fellowship in Medical Mycology
Fundação para a Ciência e a Tecnologia, Portugal
2004/09/01 - 2008/12/01 Laboratory work as PhD student.
Fundação para a Ciência e a Tecnologia, Portugal
Projects

Grant

Designation Funders
2010 - Current Alternaria infectoria FKS, CHS and melanin synthesis genes: the perfect combination for opportunism
SFRH/BPD/63733/2009
Fundação para a Ciência e a Tecnologia, I.P.
2004 - 2008 Osmotic and Thermal Adaptation in Ancient Thermophilic Bacteria: Biosynthesis of Glucosylglycerate and Mannosylglucosylglycerate
SFRH / BD / 19599 / 2004
Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2018 - Current Chronic allergic diseases and chronic inflammation originating from the gastrointestinal tract in the elderly
HEALTHY AGING 2020: CENTRO-01-0145-FEDER-000012
Other
2009 - 2011 Alternaria infectoria FKS, CHS and melanin synthesis genes: the combination for oportunism
PTDC/SAU-ESA/108636/2008
Other
Fundação para a Ciência e a Tecnologia, Portugal
2005 - 2008 Nature’s shieds to environmental stress. Biosynthesis of compatible solutes in extremely radiation-resistent Rubrobacter spp
POCI/BIA-MIC/56511/2004
Other
Fundação para a Ciência e a Tecnologia
2004 - 2006 Hotsolutes - New applications of compatible solutes from hyperthermophiles
COOP-CT-2003-508644
Other
European Commission, Belgium
Outputs

Publications

Conference poster
  1. Fernandes, Chantal. "Melanin Synthesis dual role in the Protection of Alternaria sp. against Antifungals and Immune Response". Paper presented in Microbiotec’19 Congress, 2019.
  2. Diogo, Patrícia; Mota, Marta; Fernandes, Chantal; Gonçalves, T.; Santos JM. "Eficácia antimicrobiana de irrigantes clássicos em biofilmes in vitro – 90s ou 30min de contacto?". Paper presented in Congresso da Sociedade Portuguesa de Endodontologia, Porto, 2018.
  3. Fernandes, Chantal. "Fungal melanin synthesis: a new target for antifungal agents". Paper presented in 1st Meeting on Biomedical Research @ UC, University of Coimbra, Coimbra, 2016.
  4. Fernandes, Chantal; Anjos, Jorge; Walker LA; B Silva; Cortes, L.; Mota, Marta; Munro, C. A.; Gow, Neil A.R.; Gonçalves, T.. "Modulation of cell wall chitin, glucan and melanin synthesis of Alternaria infectoria in response to cell wall synthases inhibitors". Paper presented in XVIII Congress of the Portuguese Biochemical Society, Coimbra, 2014.
  5. Fernandes, Chantal; Anjos, Jorge; Walker, L.; Prados-Rosales, Rafael; B Silva; Cortes, L.; Mota, Marta; et al. "Chitin, ß-glucan and melanin in Alternaria infectoria: the perfect combination for resistance to antifungals.". Paper presented in XII CNC Annual Meeting, Coimbra, 2014.
  6. Fernandes, Chantal; Anjos J; B Silva; Mota, Marta; Empadinhas, N.; Munro C; Walker, L.; et al. "Effect of cell wall synthases inhibitors in the modulation of cell wall chitin and glucan synthesis of Alternaria infectoria". Paper presented in XI CNC Annual Meeting, Biocant Park, Cantanhede, 2013.
  7. Fernandes, Chantal; Anjos, Jorge; Abrunheiro, Alexandra; Gonçalves, Teresa. "Effect of caspofungin and nikkomycin Z on the cell wall chitin and glucan synthesis in Alternaria infectoria". Paper presented in X CNC Annual Meeting, Biocant Park, Cantanhede, 2012.
  8. Fernandes, Chantal; Anjos, Jorge; Quintas, Célia; Abrunheiro, Alexandra; Gonçalves, Teresa. "Alternaria infectoria response to Caspofungin: modulation of ß(1,3)-glucan synthase and chitin synthases genes expression and cell wall components glucan and chitin.". Paper presented in IV FEBS Advanced Lecture Course Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence, 2011.
  9. Nuno Empadinhas; Fernandes, Chantal; Mendes, V.; Costa, J.; Santos, H.; Costa MS. "Petrotoga mobilis possesses two pathways for the synthesis of the rare compatible solute mannosyl-a-1,2-glucosylglycerate". Paper presented in XVI National Congress of Biochemistry, 22-25th October, 2008, Ponta Delgada, Açores, Portugal, 2008.
  10. Fernandes, Chantal. "Glucosylglycerate: occurrence, biosynthesis and protein stabilization". Paper presented in V CNC Annual Meeting, Coimbra, 2007.
  11. Fernandes, Chantal; Empadinhas, N.; Costa MS. "The inositol-1-phosphate synthase from Rubrobacter xylanophilus". Paper presented in 2th FEMS Congress of European Microbiologists, Madrid, Spain, 2006.
Journal article
  1. Almeida, M. C.; Antunes, D.; Silva, B. M. A.; Rodrigues, L.; Mota, M.; Borges, O.; Fernandes, C.; Gonçalves, T.. "Early Interaction of Alternaria infectoria Conidia with Macrophages". Mycopathologia 184 3 (2019): 383-392. http://dx.doi.org/10.1007/s11046-019-00339-6.
    10.1007/s11046-019-00339-6
  2. Diogo, Patrícia; Mota, Marta; Fernandes, Chantal; Sequeira, Diana; Palma, Paulo; Caramelo, Francisco; Neves, M. Graça P.M.S.; et al. "Is the chlorophyll derivative Zn(II)e 6 Me a good photosensitizer to be used in root canal disinfection?". Photodiagnosis and Photodynamic Therapy 22 (2018): 205-211. http://dx.doi.org/10.1016/j.pdpdt.2018.04.009.
    10.1016/j.pdpdt.2018.04.009
  3. Paulo Silva; Chantal Fernandes; Lillian Barros; Isabel C. F. R. Ferreira; Leonel Pereira; Teresa Gonçalves. "The antifungal activity of extracts of Osmundea pinnatifida, an edible seaweed, indicates its usage as a safe environmental fungicide or as a food additive preventing post-harvest fungal food contamination". Food & Function 9 12 (2018): 6187-6195. https://doi.org/10.1039/C8FO01797B.
    10.1039/C8FO01797B
  4. Diogo, Patrícia; Fernandes, Chantal; Caramelo, Francisco; Mota, Marta; Miranda, Isabel M.; Faustino, M. A. F.; Neves, M. G. P. M. S.; et al. "Antimicrobial Photodynamic Therapy against Endodontic Enterococcus faecalis and Candida albicans Mono and Mixed Biofilms in the Presence of Photosensitizers: A Comparative Study with Classical Endodontic Irrigants". Frontiers in Microbiology 8 (2017): http://dx.doi.org/10.3389/fmicb.2017.00498.
    10.3389/fmicb.2017.00498
  5. Soares, Fabiana; Fernandes, Chantal; Silva, Paulo; Pereira, Leonel; Gonçalves, Teresa. "Antifungal activity of carrageenan extracts from the red alga Chondracanthus teedei var. lusitanicus". Journal of Applied Phycology 28 5 (2016): 2991-2998. http://dx.doi.org/10.1007/s10811-016-0849-9.
    10.1007/s10811-016-0849-9
  6. Fernandes, Chantal; Gow, Neil A.R.; Gonçalves, Teresa. "The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi". Fungal Biology Reviews 30 1 (2016): 1-14. http://dx.doi.org/10.1016/j.fbr.2016.03.002.
    10.1016/j.fbr.2016.03.002
  7. Fernandes, Chantal; Prados-Rosales, Rafael; Silva, Branca M. A.; Nakouzi-Naranjo, Antonio; Zuzarte, Mónica; Chatterjee, Subhasish; Stark, Ruth E.; Casadevall, Arturo; Gonçalves, Teresa. "Activation of Melanin Synthesis in Alternaria infectoria by Antifungal Drugs". Antimicrobial Agents and Chemotherapy 60 3 (2015): 1646-1655. http://dx.doi.org/10.1128/aac.02190-15.
    10.1128/aac.02190-15
  8. Fernandes, C.; Anjos, J.; Walker, L. A.; Silva, B. M. A.; Cortes, L.; Mota, M.; Munro, C. A.; Gow, N. A. R.; Goncalves, T.. "Modulation of Alternaria infectoria Cell Wall Chitin and Glucan Synthesis by Cell Wall Synthase Inhibitors". Antimicrobial Agents and Chemotherapy 58 5 (2014): 2894-2904. http://dx.doi.org/10.1128/aac.02647-13.
    10.1128/aac.02647-13
  9. Anjos, Jorge; Fernandes, Chantal; Silva, Branca M. A.; Quintas, Célia; Abrunheiro, Alexandra; Gow, Neil A. R.; Gonçalves, Teresa. "ß(1,3)-glucan synthase complex fromAlternaria infectoria, a rare dematiaceous human pathogen". Medical Mycology 50 7 (2012): 716-725. http://dx.doi.org/10.3109/13693786.2012.675525.
    10.3109/13693786.2012.675525
  10. Fernandes, C.; Mendes, V.; Costa, J.; Empadinhas, N.; Jorge, C.; Lamosa, P.; Santos, H.; da Costa, M. S.. "Two Alternative Pathways for the Synthesis of the Rare Compatible Solute Mannosylglucosylglycerate in Petrotoga mobilis". Journal of Bacteriology 192 6 (2010): 1624-1633. http://dx.doi.org/10.1128/jb.01424-09.
    10.1128/jb.01424-09
  11. Nobre, A.; Alarico, S.; Fernandes, C.; Empadinhas, N.; da Costa, M. S.. "A Unique Combination of Genetic Systems for the Synthesis of Trehalose in Rubrobacter xylanophilus: Properties of a Rare Actinobacterial TreT". Journal of Bacteriology 190 24 (2008): 7939-7946. http://dx.doi.org/10.1128/jb.01055-08.
    10.1128/jb.01055-08
  12. Rodrigues, M. V.; Borges, N.; Henriques, M.; Lamosa, P.; Ventura, R.; Fernandes, C.; Empadinhas, N.; et al. "Bifunctional CTP:Inositol-1-Phosphate Cytidylyltransferase/CDP-Inositol:Inositol-1-Phosphate Transferase, the Key Enzyme for Di-myo-Inositol-Phosphate Synthesis in Several (Hyper)thermophiles". Journal of Bacteriology 189 15 (2007): 5405-5412. http://dx.doi.org/10.1128/jb.00465-07.
    10.1128/jb.00465-07
  13. Fernandes, C.; Empadinhas, N.; da Costa, M. S.. "Single-Step Pathway for Synthesis of Glucosylglycerate in Persephonella marina". Journal of Bacteriology 189 11 (2007): 4014-4019. http://dx.doi.org/10.1128/jb.00075-07.
    10.1128/jb.00075-07
  14. Fernandes, Chantal; Rainey, Fred A.; Fernanda Nobre, M.; Pinhal, Isabel; Folhas, Fátima; da Costa, Milton S.. "Herminiimonas fonticola gen. nov., sp. nov., a Betaproteobacterium isolated from a source of bottled mineral water". Systematic and Applied Microbiology 28 7 (2005): 596-603. http://dx.doi.org/10.1016/j.syapm.2005.03.013.
    10.1016/j.syapm.2005.03.013
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/09/19 Melanin contribution to antimicrobial resistance 2nd CIBB INNOVATIVE THERAPIES RETREAT
(Coimbra, Portugal)
2019/05 Atividade antidermatofítica do chá preto dos Açores uMED: IV Congresso Médico - Científico dos Açores
Universidade dos Açores
2018/03 A eficácia antimicrobiana da Clorofila é equiparável a 3% de NaOCl na Endodontia? XXVII Reunião de Medicina Dentária e Estomatologia de Coimbra
Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2017/09 Evaluation of a modified chlorophyll for aPDT applied to endodontic mix biofilmes 18º Congresso Bienal da ESE
(Brussels)
2016/12 Fungal melanin synthesis: a new target for antifungal agents 1st Meeting on Biomedical Research @ UC, University of Coimbra, Coimbra
(Portugal)
2011/12 Alternaria infectoria response to caspofungin: modulation of ß(1,3) - glucan synthase and chitin synthases genes expression and cell wall components glucan and chitin IX CNC Annual Meeting
Universidade de Coimbra
2007 Glucosylglycerate: occurrence, biosynthesis and protein stabilization V CNC Annual Meeting

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020/09/01 - Current Optimization of the recovery of extracellular vesicles from filamentous fungi
Supervisor
Mestrado em Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/07 - 2020/12/11 Interaction of filamentous fungi extracellular vesicles with respiratory tract epithelium
Supervisor
Mestrado em Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/05/02 - 2019/07/24 O papel das vesículas extracelulares de fungos filamentosos na doença fúngica
Supervisor
Licenciatura em Biotecnologia (Degree)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2016/03 - 2016/07 Study of the melanization of Candida sp. and its effect on the resistance against antifungals
Co-supervisor
Corso di Laurea Magistrale in Biologia (Degree)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2015/09 - 2016/07 Immunomodulatory effect of different components of the cell wall of Alternaria spp.
Co-supervisor
Bioquímica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/09 - 2015/07 Antifungal activity of Carrgeenan extracts from the red alga Chondracanthus teed var. lusitanicus
Co-supervisor
Mestrado em Biodiversidade e Biotecnologia Vegetal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/03 - 2015/06 Screening of biotechnological potential of Osmundea pinnatifida: cultivation trials and biological activities
Co-supervisor
Mestrado em Biodiversidade e Biotecnologia Vegetal (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2019/07/25 O papel das vesículas extracelulares de fungos filamentosos na doença fúngica
Supervisor
Rita Domingues (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2015/09 Caracterização do perfil biotecnológico de Dilsea carnosa. Ensaios de cultivo em IMTA, Análise do conteúdo coloidal, Quantificação de potencial bioativo
(Thesis) Main arguer
João Filipe Nogueira Marques (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Distinctions

Award

2018 Best Presentation
2018 Best Poster
2018 Best oral communication