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Marta Relvas-Santos graduated in Biochemistry by the Faculty of Sciences and Institute of Biomedical Sciences Abel Salazar of the University of Porto in 2016. In 2018, she completed her Master's degree in Biochemistry at the same institutions. Her dissertation focused on the comprehensive study of bladder cancer O-glycome (including the influence of microenvironmental stimuli), as well as the glycoproteome, which has allowed to guide functional studies towards targeted therapeutics. Currently, she is a PhD student at Experimental Pathology and Therapeutics Group (IPO-Porto), LAQV-REQUIMTE (FCUP), and INEB-i3S. Previously, she worked as Technician in the Mass Spectrometry laboratory of the Materials Centre of the University of Porto. Her major research areas of interest are cancer glycobiology, glycomics, glycoproteomics, and mass spectrometry.
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Identification

Personal identification

Full name
Marta Filipa Relvas dos Santos

Citation names

  • Relvas-Santos, Marta

Author identifiers

Ciência ID
EE19-E89D-2D92
ORCID iD
0000-0001-5764-5414
Researcher Id
AAE-3193-2020

Email addresses

  • marta_frds@hotmail.com (Professional)
  • marta.relvas.santos@ipoporto.min-saude.pt (Professional)

Telephones

Telephone
  • 225084000 Ext.: 5110 (Professional)

Addresses

  • Research Center of Portuguese Oncology Institute of Porto. Rua Dr. Antonio Bernardino de Almeida, 4200-072, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Exact Sciences - Chemical Sciences - Analytical Chemistry
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2024/04/04 - 2024/04/04
Concluded
 Flow cytometry: conceitos e aspetos metodológicos, desenho de painéis multiparamétricos e utilização prática de um citómetro de fluxo (Outros)
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2020/01/02 - 2024
Ongoing
 Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/10/12 - 2023/10/12
Concluded
 Life Science Intellectual Property: Management and Exploitation (Outros)
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2018/12
Concluded
 Biochemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"Bladder cancer glycome and glycoproteome microenvironmental regulation: the role of oxygen and glucose" (THESIS/DISSERTATION)
 18
2013/09 - 2016/09
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Dinâmica da população portuguesa de Drosophila suzukii " (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2021/10/20 - 2021/10/25 Visiting Researcher (Research) European Proteomics Infrastructure Consortium Providing Access, Netherlands
Universiteit Utrecht, Netherlands
2019/03 - 2019/07 Research Trainee (Research) Grupo de Investigação do Cancro Digestivo, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Others

Category
Host institution 		Employer
2020/01 - Current PhD student, at IPO-Research Center, LAQV-REQUIMTE, and INEB-i3S Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
(...)
2019/09 - 2019/12 Technician (Mass spectrometry laboratory) Universidade do Porto Centro de Materiais, Portugal
2017/09 - 2018/12 MSc student in Experimental Pathology and Therapeutics Group (IPO-Porto Research Center) and LAQV-REQUIMTE (Faculty of Sciences, University of Porto) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2015/11 - 2016/07 BSc student in the Phenotypic Evolution Group Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2024/03/01 - 2024/04/30 Construction of a multivalent glycan-based nanovaccine for bladder cancer: A step towards effective immunotherapies
COVID/BD/153652/2024
10.54499/COVID/BD/153652/2024
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2024/02/29 Construction of a multivalent glycan-based nanovaccine for bladder cancer: A step towards effective immunotherapies
SFRH/BD/146500/2019
10.54499/SFRH/BD/146500/2019
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/03/01 - 2024/08/31 REVERENT: PRE-CLINICAL VALIDATION OF A GLYCOCODE-INSPIRED VACCINE FOR BLADDER CANCER IMMUNOTHERAPY
10.54499/2022.03621.PTDC
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022 - 2024 RESOLVE: Rational Design of Multivalent Glycocode-Inspired Nanovaccines for Gastric Cancer Immunotherapy
PTDC/MED-OUT/2512/2021
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Universidade de Aveiro, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2021 - 2022 Phosphoproteomics of hypoxic and glucose deprived bladder cancer cells: the missing link towards systems oncology
EPIC-XS-0000341
Researcher
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Universiteit Utrecht, Netherlands
European Proteomics Infrastructure Consortium Providing Access
Outputs

Publications

Conference poster
  1. Relvas-Santos, Marta; Ferreira, Dylan; Peixoto, Andreia; Azevedo, Rita; Freitas, Rui; Miranda, Andreia; Afonso, Luis Pedro; et al. "Glycoengineered Cells and Targeted Glycoproteomics for Immunogenic Glycopeptides Discovery in Bladder Cancer". Paper presented in Glycobiology Gordon Research Seminar: Glycans as Central Players in Biological Processes, 2025.
  2. Relvas-Santos, Marta; Ferreira, Dylan; Peixoto, Andreia; Azevedo, Rita; Freitas, Rui; Miranda, Andreia; Afonso, Luis Pedro; et al. "Glycoengineered Cells and Targeted Glycoproteomics for Immunogenic Glycopeptides Discovery in Bladder Cancer". Paper presented in Glycobiology Gordon Research Conference: The Biological Role of Glycans as Key Regulators of Life, 2025.
  3. Relvas-Santos, Marta; Peixoto, Andreia; Ferreira, Dylan; Lara Santos, Lúcio; Silva, André M. N.; Ferreira, José Alexandre. "Exploiting Glycoengineered Simple Cells and Targeted O-glycoproteomics Towards Bladder Cancer Neoantigens". Paper presented in 1st Young Researchers' Day, 2023.
  4. Freitas, Rui; Relvas-Santos, Marta; Fernandes, Elisabete; Azevedo, Rita; Silva, André M. N.; Lara Santos, Lúcio; Ferreira, José Alexandre. "Single-pot enzymatic synthesis of short-chain MUC16 O-sialoglycopeptides and protein glycoconjugates for bioanalytical and biomedical applications". Paper presented in 13th International Meeting of the Portuguese Carbohydrate Group - GLUPOR 13 by Freitas R, 2019.
Journal article
  1. Marta Relvas-Santos; Dylan Ferreira; Andreia Brandão; Luis Pedro Afonso; Lúcio Lara Santos; André M. N. Silva; José Alexandre Ferreira. "Glycomics and Glycoproteomics Reveal Distinct Oligomannose Carriers Across Bladder Cancer Stages". International Journal of Molecular Sciences (2025): https://doi.org/10.3390/ijms26104891.
    10.3390/ijms26104891
  2. Peixoto, Andreia; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Freitas, Rui; Veth, Tim S.; Brandão, Andreia; et al. "Multilevel plasticity and altered glycosylation drive aggressiveness in hypoxic and glucose-deprived bladder cancer cells". iScience 28 2 (2025): 111758. https://doi.org/10.1016/j.isci.2025.111758.
    10.1016/j.isci.2025.111758
  3. Cotton, Sofia; Ferreira, Dylan; Relvas-Santos, Marta; Brandão, Andreia; Afonso, Luís Pedro; Miranda, Andreia; Ferreira, Eduardo; et al. "E-selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor-prognosis signature in colorectal cancer". Molecular Oncology (2024): http://dx.doi.org/10.1002/1878-0261.13733.
    10.1002/1878-0261.13733
  4. Rui Freitas; Eduardo Ferreira; Andreia Miranda; Dylan Ferreira; Marta Relvas-Santos; Flávia Castro; Beatriz Santos; et al. "Targeted and Self-Adjuvated Nanoglycovaccine Candidate for Cancer Immunotherapy". ACS Nano (2024): http://dx.doi.org/10.1021/acsnano.3c12487.
    10.1021/acsnano.3c12487
  5. Janine Soares; Mariana Eiras; Dylan Ferreira; Daniela A. R. Santos; Marta Relvas-Santos; Beatriz Santos; Martina Gonçalves; et al. "Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25073722.
    10.3390/ijms25073722
  6. Eduardo Ferreira; Dylan Ferreira; Marta Relvas-Santos; Rui Freitas; Janine Soares; Rita Azevedo; Luís Pedro Afonso; et al. "Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25063462.
    10.3390/ijms25063462
  7. Freitas R; Miranda A; Ferreira D; Relvas-Santos M; Castro F; Ferreira E; Gaiteiro C; et al. "A multivalent CD44 glycoconjugate vaccine candidate for cancer immunotherapy.". Journal of controlled release : official journal of the Controlled Release Society (2024): https://doi.org/10.1016/j.jconrel.2024.01.065.
    10.1016/j.jconrel.2024.01.065
  8. Gaiteiro, Cristiana; Soares, Janine; Relvas-Santos, Marta; Peixoto, Andreia; Ferreira, Dylan; Paulo, Paula; Brandão, Andreia; et al. "Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion". Theranostics 12 7 (2022): 3150-3177. http://dx.doi.org/10.7150/thno.67409.
    10.7150/thno.67409
  9. Peixoto, Andreia; Ferreira, Dylan; Azevedo, Rita; Freitas, Rui; Fernandes, Elisabete; Relvas-Santos, Marta; Gaiteiro, Cristiana; et al. "Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer". Journal of Experimental & Clinical Cancer Research 40 1 (2021): http://dx.doi.org/10.1186/s13046-021-01988-6.
    10.1186/s13046-021-01988-6
  10. Sofia Cotton; Dylan Ferreira; Janine Soares; Andreia Peixoto; Marta Relvas-Santos; Rita Azevedo; Paulina Piairo; et al. "Target Score—A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness". International Journal of Molecular Sciences 22 4 (2021): 1664-1664. https://doi.org/10.3390/ijms22041664.
    10.3390/ijms22041664
  11. José Alexandre Ferreira; Marta Relvas-Santos; Andreia Peixoto; André M.N. Silva; Lúcio Lara Santos. "Glycoproteogenomics: Setting the Course for Next-generation Cancer Neoantigen Discovery for Cancer Vaccines". Genomics, Proteomics & Bioinformatics (2021): https://doi.org/10.1016/j.gpb.2021.03.005.
    10.1016/j.gpb.2021.03.005
  12. Rui Freitas; Marta Relvas-Santos; Rita Azevedo; Janine Soares; Elisabete Fernandes; Beatriz Teixeira; Lúcio Lara Santos; André M. N. Silva; José Alexandre Ferreira. "Single-pot enzymatic synthesis of cancer-associated MUC16 O-glycopeptide libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines". New Journal of Chemistry (2021): https://doi.org/10.1039/D0NJ06021F.
    10.1039/D0NJ06021F
  13. Fernandes, Elisabete; Freitas, Rui; Ferreira, Dylan; Soares, Janine; Azevedo, Rita; Gaiteiro, Cristiana; Peixoto, Andreia; et al. "Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells". Cancers (2020): http://dx.doi.org/10.3390/cancers12040861.
    10.3390/cancers12040861
  14. Fernandes, Elisabete; Ferreira, Dylan; Peixoto, Andreia; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Martins, Gabriela; et al. "Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitaxel to gastric cancer cells of high metastatic potential". International Journal of Pharmaceutics 570 (2019): 118646. http://dx.doi.org/10.1016/j.ijpharm.2019.118646.
    10.1016/j.ijpharm.2019.118646
  15. Peixoto, Andreia; Relvas-Santos, Marta; Azevedo, Rita; Santos, Lúcio Lara; Ferreira, José Alexandre. "Protein Glycosylation and Tumor Microenvironment Alterations Driving Cancer Hallmarks". Frontiers in Oncology 9 (2019): http://dx.doi.org/10.3389/fonc.2019.00380.
    10.3389/fonc.2019.00380
  16. Azevedo, Rita; Soares, Janine; Gaiteiro, Cristiana; Peixoto, Andreia; Lima, Luís; Ferreira, Dylan; Relvas-Santos, Marta; et al. "Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer". Talanta 184 (2018): 347-355. http://dx.doi.org/10.1016/j.talanta.2018.03.028.
    10.1016/j.talanta.2018.03.028
  17. Azevedo, Rita; Gaiteiro, Cristiana; Peixoto, Andreia; Relvas-Santos, Marta; Lima, Luís; Santos, Lúcio Lara; Ferreira, José Alexandre. "CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications". Clinical Proteomics 15 1 (2018): http://dx.doi.org/10.1186/s12014-018-9198-9.
    10.1186/s12014-018-9198-9
Preprint
  1. Andreia Miranda; Marta Relvas-Santos; Camila Lourenço; Eduardo Ferreira; Diogo M. Cunha; Carlos Palmeira; Lúcio Lara Santos; Pieta K Mattila; José Alexandre Ferreira. "GlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome". 2025. https://doi.org/10.1101/2025.01.15.633146.
    10.1101/2025.01.15.633146
  2. Andreia Peixoto; Dylan Ferreira; Andreia Miranda; Marta Relvas-Santos; Rui Freitas; Tim S. Veth; Andreia Brandão; et al. "Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells". 2023. https://doi.org/10.1101/2023.10.21.561355.
    10.1101/2023.10.21.561355

Intellectual property

Patent
  1. Ferreira, José Alexandre; André Moreira Neto da Silva; Rui Filipe Neves Freitas; Lúcio Lara Santos; Relvas-Santos, Marta; Cristiana Milhazes Gaiteiro; ANDREIA FILIPA FERREIRA PEIXOTO; et al. 2023. "CD44 GLYCOEPITOPES AND CHIMERIC VACCINE GLYCOCONJUGATES FOR CANCER THERAPY AND SYNTHESIS METHODS THEREOF".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/03/23 Glycoengineered Cells and Targeted Glycoproteomics for Immunogenic Glycopeptides Discovery in Bladder Cancer Glycans as Central Players in Biological Processes
Glycobiology Gordon Research Seminar (Lucca, Italy)
2024/11/28 Glycoengineered Cells and Targeted O-Glycoproteomics for Immunogenic Glycopeptides Discovery in Bladder Cancer 2nd Young Researchers' Day
(Porto, Portugal)
2024 Since 2018, I am contributing author of several abstracts selected for oral communication (including invited keynote lectures) in national and international conferences
2022/05/12 Exploiting Glycoengineered Simple Cells and Bioinformatics-Assisted Glycoproteomics for Bladder Cancer Targets Prioritization ProteoVilamoura 2022 - 2nd Joint Meeting of Spanish, French and Portuguese Proteomics Societies
(Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/03/23 - 2025/03/28 The Biological Role of Glycans as Key Regulators of Life - Glycobiology GRC
Conference
 The Biological Role of Glycans as Key Regulators of Life
Glycobiology Gordon Research Conference, Italy
2025/03/22 - 2025/03/23 Glycans as Central Players in Biological Processes - Glycobiology GRS
Seminar
 Glycans as Central Players in Biological Processes
Glycobiology Gordon Research Seminar, Italy
2024/11/28 - 2024/11/28 2nd Young Researchers' Day
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2023/11/09 - 2023/11/09 1st Young Researchers' Day
Congress
 1st Young Researchers' Day
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2022/05/13 - 2022/05/13 C-HPP Satellite Workshop on “Accelerating the HPP Grand Challenge” Chromosome-centric Human Proteome Project
2022/05/11 - 2022/05/13 ProteoVilamoura 2022 - 2nd Joint Meeting of Spanish, French and Portuguese Proteomics Societies Portuguese Association of Proteomics - REDE PROCURA
2020/11/09 - 2020/11/12 Society for Glycobiology 2020 Virtual Annual Meeting
Society for Glycobiology, United States
2019/05/09 - 2019/05/09 Translational Glycobiology Towards the Treatment of Cancer GlyCoCan - Marie Curie European Training Network, Vrije University of Amsterdam, Netherlands
2018/07/14 - 2018/07/19 29th International Carbohydrate Symposium in 2018 (ICS 2018)
Universidade de Lisboa Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - Current Computational and Structural Biotechnology Journal Elsevier
2024 - Current International Journal of Pharmaceutics Elsevier

Association member

Society Organization name Role
2024 - Current Females in Mass Spectrometry Member
2022 - Current Portuguese Association of Proteomics - REDE PROCURA
2018 - Current Portuguese Chemical Society

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/11/12 Advancing Bladder Cancer Research with Mass Spectrometry: A FeMS Interview with Marta Relvas-Santos LCGC International
Distinctions

Award

2024 Females in Mass Spectrometry Empowerment Award