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Identification

Personal identification

Full name
Shrika Guirishchandra Harjivan

Citation names

  • Harjivan, Shrika

Author identifiers

Ciência ID
EE18-01C8-12C1
ORCID iD
0000-0002-1975-1571

Email addresses

  • sharjivan@ff.ulisboa.pt (Professional)
  • sharjivan@farm-id.pt (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Education
Degree Classification
2017/03/28
Concluded
Chemistry (Doutoramento)
Major in Medicinal Chemistry
Universidade de Lisboa Instituto Superior Técnico, Portugal
"CHEMICAL MODIFICATION OF BIONUCLEOPHILES BY NNRTI METABOLITES: A MOLECULAR BASIS FOR NON-AIDS DEFINING CANCERS AND OTHER TOXIC EFFECTS?" (THESIS/DISSERTATION)
Aprovado com distinção
2008
Concluded
Chemistry (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Synthesis of Organometallic compounds with potential therapeutic properties" (THESIS/DISSERTATION)
16
2007
Concluded
Chemistry (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
13
Affiliation

Science

Category
Host institution
Employer
2018/12/03 - Current Contracted Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/10/15 - 2018/12/02 Postdoc (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/09/01 - 2018/09/30 Postdoc (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution
Employer
2012/02/01 - 2018/03/28 PhD student (SFRH / BD / 80690 / 2011) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2011/05/01 - 2012/01/31 Bioactivation routes of the anti-HIV drug Nevirapine: identification of reactive metabolites and mutagenic potential
PTDC/QUI-QUI/113910/2009 funded by FCT)
Research Fellow
Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/02/02 - 2011/01/01 Design, synthesis and biological evaluation of bioorganometallic benzo[b]thiophenes as potential anticancer agents
PTDC/QUI/67522/2006
Research Fellow
Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
2009/01 - 2011/01 Design, synthesis and biological evaluation of bioorganometallic benzo[b]thiophenes as potential anticancer agents
PTDC/QUI/67522/2006
Research Fellow
N/A
2008/01/06 - 2008/06/30 Synthesis and Evaluation of a novel Germanium based Anti-Cancer drugs
00000
Research Fellow
Blackwell's Reading University, United Kingdom
Concluded

Contract

Designation Funders
2018/12/01 - 2021/05/31 Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MEDFAR/30266/2017
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
Ongoing
2018/12 - 2021/05 Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MEDFAR/30266/2017
N/A

Other

Designation Funders
2012/02/01 - 2017/03/28 Chemical modification of bionucleophiles by NNRTI metabolites: A molecular basis for non-AIDS defining cancers and other toxic effects?
x
PhD Student Fellow
Universidade de Lisboa Centro de Química Estrutural, Portugal
2007/09/10 - 2007/12/31 New Bioorganometallic Maraviroc Analogues as potential CCR5 antagonists
000
Project student for the M.Sc thesis
Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
Outputs

Publications

Journal article
  1. Shrika G. Harjivan; Catarina Charneira; Inês L. Martins; Sofia A. Pereira; Guadalupe Espadas; Eduard Sabidó; Frederick A. Beland; M. Matilde Marques; Alexandra M. M. Antunes. "Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine". Molecules 26 5 (2021): 1349-1349. https://doi.org/10.3390/molecules26051349.
    10.3390/molecules26051349
  2. Harjivan, Shrika. "Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds.". International journal of molecular sciences (2020): https://europepmc.org/articles/PMC7700174.
    10.3390/ijms21228854
  3. Pinheiro, P.F.; Pereira, S.A.; Harjivan, S.G.; Martins, I.L.; Marinho, A.T.; Cipriano, M.; Jacob, C.C.; et al. "Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study". Archives of Toxicology 91 3 (2017): 1199-1211. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978906447&partnerID=MN8TOARS.
    10.1007/s00204-016-1792-x
  4. Sousa, Maria; Araújo, Maria; do Vale, Maria; Andrade, Paula; Branco, Paula; Gomes, Paula; Moreira, Rui; Pinho e Melo, Teresa; Freitas, Victor. "11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry". Pharmaceuticals 9 1 (2016): 15. http://dx.doi.org/10.3390/ph9010015.
    Published • 10.3390/ph9010015
  5. Grilo, N.M.; Correia, M.J.; Sequeira, C.; Harjivan, S.G.; Caixas, U.; Diogo, L.N.; Marques, M.M.; et al. "Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients". Toxicology Letters 260 (2016): 28-35. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987995250&partnerID=MN8TOARS.
    10.1016/j.toxlet.2016.08.009
  6. Harjivan, S.G.; Wanke, R.; Woodling, K.; da Costa, G. Gamboa; Beland, F.A.; Antunes, A.M.M.; Marques, M.M.. "First in vitro evidence for a catechol metabolite from the anti-HIV drug efavirenz – A plausible role in toxicity". Toxicology Letters 238 2 (2015): S360. http://dx.doi.org/10.1016/j.toxlet.2015.08.1026.
    Published • 10.1016/j.toxlet.2015.08.1026
  7. Harjivan, S.G.; Pinheiro, P.F.; Martins, I.L.; Novais, D.A.; Wanke, R.; Santos, P.P.; Pereira, S.A.; et al. "Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids". Toxicology Letters 238 2 (2015): S359-S360. http://dx.doi.org/10.1016/j.toxlet.2015.08.1025.
    Published • 10.1016/j.toxlet.2015.08.1025
  8. Pereira, S.A.; Antunes, A.M.M.; Dias, C.G.; Marinho, A.T.; Harjivan, S.G.; Fonseca, M.; Maia, S.; et al. "Anti-histone antibodies in HIV-infected patients on Nevirapine-containing ANTIRETROVIRAL THERAPY". Clinical Therapeutics 37 8 (2015): e142. http://dx.doi.org/10.1016/j.clinthera.2015.05.408.
    10.1016/j.clinthera.2015.05.408
  9. Ferreira Da Silva, J.L.; Harjivan, S.G.; Ferreira, A.P.; Shimizu, K.; Matilde Marques, M.; Duarte, M.T.. "Effect of substituents in the molecular and supramolecular architectures of 1-ferrocenyl-2-(aryl)thioethanones". CrystEngComm 17 16 (2015): 3089-3102. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927779574&partnerID=MN8TOARS.
    10.1039/c5ce00149h
  10. Harjivan, S.G.; Pinheiro, P.F.; Martins, I.L.; Godinho, A.L.; Wanke, R.; Santos, P.P.; Pereira, S.A.; et al. "Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: Activation pathway to amino acid adducts". Toxicology Research 4 6 (2015): 1565-1577. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945273743&partnerID=MN8TOARS.
    10.1039/c5tx00176e
  11. Marinho, A.T.; Rodrigues, P.M.; Caixas, U.; Antunes, A.M.M.; Branco, T.; Harjivan, S.G.; Marques, M.M.; Monteiro, E.C.; Pereira, S.A.. "Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions". Journal of Antimicrobial Chemotherapy 69 2 (2014): 476-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892474574&partnerID=MN8TOARS.
    10.1093/jac/dkt359
  12. Harjivan, S.G.; Wanke, R.; Ferreira Da Silva, J.L.; Marques, M.M.; Antunes, A.M.M.. "The phenolic metabolites of the anti-HIV drug efavirenz: Evidence for distinct reactivities upon oxidation with Frémy's salt". European Journal of Medicinal Chemistry 74 (2014): 7-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892570484&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.12.022
  13. Miranda, J.P.; Pinheiro, P.F.; Marinho, A.T.; Harjivan, S.G.; Castro, M.; Pereira, S.A.; Antunes, A.M.M.; Marques, M.M.. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity". Toxicology Letters 221 (2013): S174. http://dx.doi.org/10.1016/j.toxlet.2013.05.384.
    Published • 10.1016/j.toxlet.2013.05.384
  14. Wanke, R.; Harjivan, S.G.; Pereira, S.A.; Marques, M.M.; Antunes, A.M.M.. "The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: A nuclear magnetic resonance study". International Journal of Antimicrobial Agents 42 5 (2013): 443-446. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885431678&partnerID=MN8TOARS.
    10.1016/j.ijantimicag.2013.06.023
  15. Ferreira da Silva, J.; Antunes, A.; Sidarius, M.; Novais, D.; Harjivan, S.; Santos, P.; Beland, F.; Marques, M.. "Supramolecular structure of an unusual nevirapine derivative". Acta Crystallographica Section A Foundations of Crystallography 68 a1 (2012): s212-s212. http://dx.doi.org/10.1107/s0108767312095906.
    Published • 10.1107/s0108767312095906
  16. Antunes, A.M.M.; Sidarus, M.; Novais, D.A.; Harjivan, S.G.; Santos, P.P.; Ferreira Da Silva, J.L.; Beland, F.A.; Marques, M.M.. "Oxidation of 2-hydroxynevirapine, a phenolic metabolite of the anti-HIV drug nevirapine: Evidence for an unusual pyridine ring contraction". Molecules 17 3 (2012): 2616-2627. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858980839&partnerID=MN8TOARS.
    10.3390/molecules17032616
  17. Wanke, R.; Novais, D.A.; Harjivan, S.G.; Marques, M.M.; Antunes, A.M.M.. "Biomimetic oxidation of aromatic xenobiotics: Synthesis of the phenolic metabolites from the anti-HIV drug efavirenz". Organic and Biomolecular Chemistry 10 23 (2012): 4554-4561. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862206244&partnerID=MN8TOARS.
    10.1039/c2ob25212k
  18. Ferreira Da Silva, J.L.; Ferreira, A.P.; Marques, M.M.; Harjivan, S.G.; M. Da Piedade, M.F.; Duarte, M.T.. "Effect of C-H...X interactions (X = O, S, p) in the supramolecular arrangements of 3-ferrocenyl-methoxybenzo[b]thiophene isomers". CrystEngComm 13 5 (2011): 1638-1645. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951790400&partnerID=MN8TOARS.
    10.1039/c0ce00434k
  19. Ferreira, A.P.; Ferreira Da Silva, J.L.; Duarte, M.T.; Fátima Minas Da Piedade, M.; Paula Robalo, M.; Harjivan, S.G.; Marzano, C.; Gandin, V.; Matilde Marques, M.. "Synthesis and characterization of new organometallic benzo[b]thiophene derivatives with potential antitumor properties". Organometallics 28 18 (2009): 5412-5423. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349326103&partnerID=MN8TOARS.
    10.1021/om9003835
Thesis / Dissertation
  1. Harjivan, Shrika. "Chemical modification of bionucleophiles by NNRTI metabolites: A molecular basis for non-AIDS defining cancers and other toxic effects?". PhD, Universidade de Lisboa Centro de Química Estrutural, 2017.
  2. Harjivan, Shrika. "Synthesis of Organometallic Compounds with Potential Therapeutic Properties". Master, Universidade de Lisboa Centro de Química Estrutural, 2008.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/07/16 Structural optimization of hit azaaurone chemotypes for the study of molecular targets involved in tuberculosis 4th Meeting of the College of Chemistry Chemistry: Shaping the Future & 2019 Summer School
Universidade de Lisboa - Faculdade de Farmácia (Lisboa, Portugal)
2014/12/05 Biomarkers of the anti-HIV drug - Efavirenz CQE Young Researchers day
Universidade de Lisboa - IST- Centro de Química Estrutural (Lisboa, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2018/09/10 - 2020/06/03 Hit optimization to improve aqueous solubility of compounds with anytmycobaterial activity
Co-supervisor
Mestrado em Química Farmacêutica e Terapêutica (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2019/11/14 - 2019/11/15 Postdoc Meeting is to promote communication and collaboration amongst PhD holders in a wide variety of fields with a focus on the life sciences (from fundamental physics to applied biomedicine). https://lapd2019.wordpress.com/
Meeting
Lisbon Area Postdoc Meeting 2019
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/10/21 - 2019/10/24 Update on mass spectrometry for lipidomics an proteomic.
Seminar
Hands on course on “Highthroughput resolution Mass Spectrometry”
Universidade de Aveiro, Portugal
2019/07/04 - 2019/07/04 Round Table aiming new collaborations for the iMedULisboa call: Young Investigator Projects for Collaborative Cross-disciplinary Studies
Round table
Young Investigator Projects for Collaborative Cross-disciplinary Studies
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/11/02 - 2011/11/04 Extensive formation on high resolution mass spectrometry for identification of biomolecules.
Workshop
Hands on course on “Protein Identification by Mass Spectrometry
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/03/15 - 2010/03/18 Extensive theoretical and practical formation on protein-ligand NMR interactions by NMR.
Workshop
Hands on course on "Ligand Based NMR Interaction Studies"
Universidade Nova de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
2009/10/09 - 2009/10/09 Extensive theoretical and practical formation on mass spectrometry, nuclear magnetic ressonance and X-ray diffraction
Workshop
Modern Methods of Structure Elucidation: Mass, NMR and X-Ray
Universidade de Lisboa Instituto Superior Técnico, Portugal
2006/02/06 - 2006/02/10 Collaborator of Open Day Laboratórios Abertos - 2006 - A day where the research laboratories are open to undergraduate students in Chemistry department
Exhibition
Laboratório sAbertos 2006
Universidade de Lisboa Instituto Superior Técnico, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2021/12/21 Addressing the electron transport chain as a target in the development of new anti-tuberculosis drugs
(Thesis) Arguer
Daniela Alexandra Oliveira Canudo (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2021/11/24 - 2021/12/06 Synthesis of hit azaaurone chemotypes with potential anti-tuberculosis activity - Supevision of a project enrolled in a laboratory rotation of PhD chemistry programme (FCT). Bernardo Vieira
2019/06/01 - 2019/06/06 Structural optimization of hit azaaurone chemotypes for the study of molecular targets involved in tuberculosis João Luís Pinto Ribeiro