???global.info.a_carregar???
Paula Mota concluded Veterinary Medicine, at University of Trás-os-Montes e Alto Douro, in 2001. From 2001 to 2004 she acted as Small Animal Internal Medicine doctor in different veterinary clinics. She changed course and decided to enroll in the Master of Cellular and Molecular Biology at University of Coimbra in 2004. After concluding this program in 2006 she received a new scholarship for a PhD in Cell Biology, area of Animal Reproduction (2006-2011). In 2011 she was awarded a highly competitive FCT post-Doctoral fellowship and secured her own funding, crucial for an early-stage scientist, to further develop alternative methods to study and recover the fertility of endangered felids. At the starting point of her post-doctoral program she was awarded a fellowship by the Welcome Burrows Foundation (USA) to attend the “Frontiers in Reproduction” at the MBL, Woods Whole, USA, a program set to widen the researchers perspective of the Reproductive field but introducing knowledge common to many other areas of application. From 2011 to 2015 she deepened her collaboration with the German Center of Reproductive Medicine & Andrology (CeRA), partially supported by a cooperation project granted to her (Portuguese team, FCT-DAAD) from 2013 to 2015. At CeRA she researched possible methods to restart spermatogenesis ex-vivo, contacting with other animal models, namely marmosets. The challenges raised by the new scheme of science funding lead her to participate in an entrepreneurship course in 2015 to acquire and develop business skills and add Laboratory Animal Science and Welfare as another area of scientific and professional interest. In order to expand her scientific knowledge in this area and acquire the necessary skills she enrolled in the Master in Laboratory Animal Science and Welfare (Universitat Autònoma de Barcelona). This program is accredited by FELASA in the category Specialist and is part of the training for Diplomats of the European College of Laboratory Animal Medicine (ECLAM). In 2018 she was forced to delay the conclusion of the Master due to maternity leave. In November 2015 she joined the Animal Facility team of Center of Neuroscience and Cell Biology (FMUC/CNC Animal Facility) as Designated Veterinarian and ORBEA (Órgão Responsável pelo Bem-Estar Animal) responsible for the improvement of the 3Rs and experimental design. During her post-doctoral fellowship and funded project, Paula supervised a team of 10 members, 1 MSc student, published 3 papers as first author, 2 papers as senior author and participated in other projects, as team member or occasional collaboration, that granted her 6 papers in different areas of scientific activity. At the end of her post-doctoral fellowship, in 2017, she was hired as Designated Veterinarian and Animal Facility Coordinator of CNC Animal Facilities were she has been responsible for i) CNC_UC:BIOTECH Specific Pathogen Free and FMUC/CNC Conventional Animal Facilities management, ii) supervision of Animal Welfare, iii) ORBEA liaison member with DGAV and other Portuguese ORBEA, and iv) training of researchers in Laboratory Animal Science and Welfare, through the organization and lecturing of courses that fulfil the training requirements under EU Directive 63/2010 and DL 113/2013, and for the continuous education of the CNC ORBEA members. Since 2020 she teaches Laboratory Animal Science to Veterinary Nursery undergraduates. She continues to participate in research project, as team member or consultant, using her scientific and professional background to help bridge between scientific objectives and animal welfare and providing a dual perspective of who's in and out of the box.
Identification

Personal identification

Full name
Paula Cristina Cardoso Ramos Mota

Citation names

  • Mota, Paula C
  • Mota, P

Author identifiers

Ciência ID
EC1D-0C0A-75EF
ORCID iD
0000-0001-9374-3476

Knowledge fields

  • Agrarian Sciences - Veterinary Sciences
  • Agrarian Sciences - Veterinary Sciences
  • Natural sciences - Biological Sciences - Reproductive Biology
  • Natural sciences - Biological Sciences - Developmental Biology
  • Natural sciences - Biological Sciences - Reproductive Biology
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Agrarian Sciences - Veterinary Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Advanced (C1) Intermediate (B1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2015/10 - 2022/12
Ongoing
Master in Laboratory Animal Science and Welfare (Master)
Universitat Autònoma de Barcelona, Spain
2016/02/10 - 2016/03/11
Concluded
IneoStart (Curso de Especialização Tecnológica)
Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
Aprovado
2011/05/01 - 2011/06/11
Concluded
"Frontiers in Reproduction - Molecular and Cellular Concepts and Applications – FIR 2011 (Postgraduate Certificate)
Major in Reproductive Biology
Marine Biological Laboratory, United States
Aprovado
2006/05 - 2011/02
Concluded
PhD in Biology (Doutoramento) (Doutoramento)
Major in Cell Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"The domestic cat as a model for endangered felids: From mitochondria as a screening tool to testis tissue xenografting for fertility recovery" (THESIS/DISSERTATION)
Approved unanimously with distinction and honors
2007/08/05 - 2007/08/10
Concluded
“2007 Frontiers in Human Embryonic Stem Cells” (Postgraduate Certificate)
Major in Developmental Biology
University of Pittsburgh School of Medicine, Magee-Womens Research Institute , United States
2003/10 - 2006/02
Concluded
Master in Cell and Molecular Biology (Mestrado)
Major in Reproductive Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Análise da qualidade espermática em felídeos: desenvolvimento e comparação de diferentes marcadores no gato doméstico" (THESIS/DISSERTATION)
Muito Bom
1995/10 - 2001/07/18
Concluded
Medicina Veterinária (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, Portugal
"Medicina Veterinária" (THESIS/DISSERTATION)
15
2000/10 - 2001/04
Concluded
Curricular trainee - Small Animals Clinics and Surgery (Postgraduate Certificate)
University of Santiago de Compostela, Faculty of Veterinary Medicine of Lugo, Spain

Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, Portugal
"Congenital canine aortic stenosis" (THESIS/DISSERTATION)
17
Affiliation

Science

Category
Host institution
Employer
2019/11/01 - Current Contracted Researcher (Research) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/05/01 - 2017/04/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2020/11/23 - 2022/09/30 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Other Careers

Category
Host institution
Employer
2017/05/01 - 2019/10/30 Técnico Superior (Técnico Superior) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution
Employer
2001/11/01 - 2003/05/30 Médica Veterinária Clínica Veterinária do Picôto, Portugal
Clínica Veterinária do Picôto, Portugal
Projects

Grant

Designation Funders
2011/04/01 - 2017/04/30 New strategies to recover fertility and genetic variability of endangered felids: development of xenografting & spermatogonial stem cell transplantation in domestic cat as model for endangered felids
SFRH/BPD/74252/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006/03/01 - 2010/02/28 An approach to infertility problems in wild cat. Integrated analysis of spermatogenesis in the domestic cat: hormonal regulation, histomorphometric study and in vitro culture
SFRH/BD/23643/2005
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021 - Current Zfra 1-31: an early intervention in T2D-associated neurodegeneration
EXPL/MED-FSL/0033/2021
Consultant
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2021 - 2023 Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study
ESCI 2021
Consultant
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Society for Clinical Investigation
Ongoing
2018/07/06 - 2021/07/05 Searching for novel biomarkers in unknown origin (UOMI) male infertility"
PTDC/MEC-AND/28599/2017
POCI-01-0145-FEDER-028599
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/05/01 - 2015/09/30 New strategies to recover fertility and genetic variability of endangered felids: development of xenografting and spermatogonial stem cell transplantation in domestic cat as model for endangered felids
PTDC/CVT/119477/2010
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2015/05/31 "Fertility preservation in endangered felids"
57035966
Principal investigator
Universidade de Coimbra, Portugal

Universitätsklinikum Münster Centrum für Reproduktionsmedizin und Andrologie, Germany
Associação para a Inovação e Desenvolvimento da FCT

Deutscher Akademischer Austauschdienst
Concluded
2013/07/03 - 2015/01/02 Novel insights into the reproductive dysfunction in diabetes: 3D dimensional analysis of spermatogenesis and analysis of mitochondria status through Confocal Raman Microscopy
EXPL/BEX-BCM/0224/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Andreia F. Silva; Suresh Yenugu; Sara Escada-Rebelo; Sandra Amaral; Renata S. Tavares; Stefan Schlatt; João Ramalho-Santos; Paula C. Mota. "Can we induce spermatogenesis in the domestic cat using an in vitro tissue culture approach?". PLOS ONE 13 2 (2018): e0191912-e0191912. https://doi.org/10.1371/journal.pone.0191912.
    10.1371/journal.pone.0191912
  2. Tavares, Renata S.; Portela, Joana M. D.; Sousa, Maria I.; Mota, Paula C.; Ramalho-Santos, João; Amaral, Sandra. "High glucose levels affect spermatogenesis: an in vitro approach". Reproduction, Fertility and Development 29 7 (2017): 1369. http://dx.doi.org/10.1071/rd15475.
    10.1071/rd15475
  3. Mota, Paula C. "Spermatogonial stem cell organization in felid testis as revealed by Dolichos biflorus lectin". Andrology (2016):
    10.1111/andr.12223
  4. Tavares, R S; Escada-Rebelo, S; Correia, M; Mota, P C; Ramalho-Santos, J. "The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm". REPRODUCTION 151 1 (2016): R1-R13. http://dx.doi.org/10.1530/rep-15-0355.
    Accepted • 10.1530/rep-15-0355
  5. Portela, J M D; Tavares, R S; Mota, P C; Ramalho-Santos, J; Amaral, S. "High glucose concentrations per se do not adversely affect human sperm function in vitro". REPRODUCTION 150 1 (2015): 77-84. http://dx.doi.org/10.1530/rep-15-0100.
    10.1530/rep-15-0100
  6. Carvalho, C.; Machado, N.; Mota, P.C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I.. "Type 2 diabetic and alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies". Journal of Alzheimer's Disease 35 3 (2013): 623-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880196052&partnerID=MN8TOARS.
    10.3233/JAD-130005
  7. Pereira, S.P.; Pereira, G.C.; Pereira, C.V.; Carvalho, F.S.; Cordeiro, M.H.; Mota, P.C.; Ramalho-Santos, J.; Moreno, A.J.; Oliveira, P.J.. "Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats". Environmental Pollution 180 (2013): 281-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879443261&partnerID=MN8TOARS.
    10.1016/j.envpol.2013.05.049
  8. Mota, Paula C.; Tavares, Renata S.; Cordeiro, Marília; Pereira, Susana P.; Publicover, Stephen J.; Oliveira, Paulo J.; Ramalho-Santos, João. "Acute effects of TCDD administration: special emphasis on testicular and sperm mitochondrial function". Asian Pacific Journal of Reproduction 1 4 (2012): 269-276. http://dx.doi.org/10.1016/s2305-0500(13)60091-3.
    10.1016/s2305-0500(13)60091-3
  9. Mota, P.C.; Ehmcke, J.; Westernströer, B.; Gassei, K.; Ramalho-Santos, J.; Schlatt, S.. "Effects of different storage protocols on cat testis tissue potential for xenografting and recovery of spermatogenesis". Theriogenology 77 2 (2012): 299-310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855565118&partnerID=MN8TOARS.
    10.1016/j.theriogenology.2011.07.042
  10. Mota, P.C.; Cordeiro, M.; Pereira, S.P.; Oliveira, P.J.; Moreno, A.J.; Ramalho-Santos, J.. "Differential effects of p,p'-DDE on testis and liver mitochondria:Implications for reproductive toxicology". Reproductive Toxicology 31 1 (2011): 80-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551613557&partnerID=MN8TOARS.
    10.1016/j.reprotox.2010.09.010
  11. Mota, P.C.; Ramalho-Santos, J.; Schlatt, S.. "Xenografting as a tool to preserve endangered species: Outcomes and challenges in model systems". Veterinary Medicine International 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863913463&partnerID=MN8TOARS.
    10.4061/2011/629409
  12. Ramalho-Santos, J.; Varum, S.; Amaral, S.; Mota, P.C.; Sousa, A.P.; Amaral, A.. "Mitochondrial functionality in reproduction: From gonads and gametes to embryos and embryonic stem cells". Human Reproduction Update 15 5 (2009): 553-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-69049087814&partnerID=MN8TOARS.
    10.1093/humupd/dmp016
  13. Mota, P.; Amaral, S.; Martins, L.; de Lourdes Pereira, M.; Oliveira, P.J.; Ramalho-Santos, J.. "Mitochondrial bioenergetics of testicular cells from the domestic cat (Felis catus)-A model for endangered species". Reproductive Toxicology 27 2 (2009): 111-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549148154&partnerID=MN8TOARS.
    10.1016/j.reprotox.2009.01.008
  14. Amaral, S.; Mota, P.C.; Lacerda, B.; Alves, M.; Pereira, M.d.L.; Oliveira, P.J.; Ramalho-Santos, J.. "Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats". Mitochondrion 9 1 (2009): 41-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-60249101037&partnerID=MN8TOARS.
    10.1016/j.mito.2008.11.005
  15. Amaral, S.; Mota, P.; Rodrigues, A.S.; Martins, L.; Oliveira, P.J.; Ramalho-Santos, J.. "Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak". FEBS Letters 582 30 (2008): 4191-4196. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649108974&partnerID=MN8TOARS.
    10.1016/j.febslet.2008.11.020
  16. Mota, P.C.; Ramalho-Santos, J.. "Comparison between different markers for sperm quality in the cat: Diff-Quik as a simple optical technique to assess changes in the DNA of feline epididymal sperm". Theriogenology 65 7 (2006): 1360-1375. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644987545&partnerID=MN8TOARS.
    10.1016/j.theriogenology.2005.08.016
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/05/17 Designated Veterinarian – the dynamic balance between animal welfare and the evolution of science Lecture in the class Bioteria geral, ética e legislação, Licenciatura em Ciências Bioveterinárias
Escola Universitária Vasco da Gama (Coimbra, Portugal)
2018/05/25 Round-Table discussion - “TestEthics”. Mota PC and Ehmcke J - Ethics in Animal Experimentation in the Reproductive Field; Schlatt S, Ramalho-Santos J and Almeida-Santos - Ethics in the Reproductive Medicine; Firmino T – Ethics in science communication 18th European Testis Workshop
(Óbidos, Portugal)
2018/01/26 Society point of view on animal research - And what can scientific community do to improve animal research acceptance- SoftSkills/PDBEB”, SoftSkills/PDBEB
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016/06/10 Can we induce spermatogenesis in domestic cat using an organ culture approach? Frontiers in Reproduction Symposium
Marine Biological Laboratories (Woods hole, MA, United States)
2012/12/17 Transplantation of testicular tissue to immune-compromised mice as an alternative approach to gamete production. New approaches to experimental research- ZTE Seminars
Zentrale Tierexperimentelle Einrichtung - MEDIZINISCHE FAKULTÄT MÜNSTER (Muenster, Germany)
2010/05/05 Testicular cryopreservation and xenografting: an experimental strategy for preservation of feline species?
LeibnizInstitut fu¨r Zoo und Wildtierforschung (Berlin, Germany)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2012 - 2014 A cat problem: Characterization, sorting and purification of spermatogonial stem cells
Supervisor
Mestrado em Biologia Celular e Molecular (Master)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2018/11/15 - 2018/11/15 III National ORBEA Symposium (2018/11/15)
Symposium (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 19th European Testis Workshop - European Workshop on the Molecular and Cellular Endocrinology of the Testis (2018/05/23 - 2018/05/26)
Congress (Member of the Organising Committee)

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2020/12/10 A novel approach for non-invasive monitoring and signaling of humane endpoints using infrared thermography, tested in a murine model of sepsis
(Thesis) Main arguer
Catarina da Silva Miranda (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2021/06 - Current SPCAL - Portuguese Society of Laboratory Animal science (Sociedade Portuguesa de Ciência em Animais de Laboratório) secretary of the board of the SPCAL assembly

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2007/01 - Current Biologia da Reprodução Mestrado em Biologia Celular e Molecular (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra, Portugal
2021/11/15 - 2021/11/26 V Modular Structure Course in Laboratory Animal Science - Rodents, prepared in accordance with the recommendations of the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 including guidance document on Education and Training Framework and Decreto-Lei n.º 113/2013 de 7 de agosto. Laboratory Animal Science (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2020/11/09 - 2020/11/20 IV Modular Structure Course in Laboratory Animal Science - Rodents, prepared in accordance with the recommendations of the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 including guidance document on Education and Training Framework and Decreto-Lei n.º 113/2013 de 7 de agosto. Laboratory Animal Science (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2019/11/04 - 2019/11/15 III Modular Structure Course in Laboratory Animal Science - Rodents, prepared in accordance with the recommendations of the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 including guidance document on Education and Training Framework and Decreto-Lei n.º 113/2013 de 7 de agosto. Laboratory Animal Science (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2019/01/07 - 2019/01/18 II Modular Structure Course in Laboratory Animal Science - Rodents, prepared in accordance with the recommendations of the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 including guidance document on Education and Training Framework and Decreto-Lei n.º 113/2013 de 7 de agosto. Laboratory Animal Science (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09/26 - 2017/10/06 I Modular Structure Course in Laboratory Animal Science - Rodents, prepared in accordance with the recommendations of the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 including guidance document on Education and Training Framework and Decreto-Lei n.º 113/2013 de 7 de agosto. Laboratory Animal Science (Especialização pós-licenciatura) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Distinctions

Award

2016 Grant by the "Burrows Welcome Found" in order to apply to Frontiers in Reproduction Symposium (June 2016).
Burrows Welcome Foundation, United States
2011 “Burrows Welcome Foundation” grant - Frontiers in Reproduction Summer course