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Identification

Personal identification

Full name
Pedro Rafael da Costa Antas

Citation names

  • Antas, Pedro

Author identifiers

Ciência ID
EC17-F611-227D
ORCID iD
0000-0002-4149-943X

Email addresses

  • pedro.antas@research.fchampalimaud.org (Professional)

Addresses

  • Avenida Brasília, 1400-038 L, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Clinical Medicine - Other Clinical Medicine Subjects

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2024
Concluded
 Medicine (Mestrado integrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017
Concluded
 Doctor of Philosophy, Ph.D. (Doutoramento)
Major in Cancer Biology
University College of London, United Kingdom

The Francis Crick Institute, United Kingdom
"Identification and characterisation of novel Wnt regulators in colorectal cancer" (THESIS/DISSERTATION)
2010
Concluded
 Human Biology and Environment, MSc (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Genetic and functional analyses of the gene rnr, an exoribonuclease from Burkholderia cenocepacia: implications in the response to temperature stress, in cell cycle regulation and virulence" (THESIS/DISSERTATION)
 _
2007
Concluded
 Cell Biology and Biotechnology, BSc. (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
 _
Affiliation

Science

Category
Host institution 		Employer
2022/03/01 - Current Research Assistant (Research) Fundação Champalimaud, Portugal
2018/07/01 - 2024/12/31 Postdoc (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017/12/01 - 2018/06/01 Postdoc (Research) The Francis Crick Institute, United Kingdom
2012/01/01 - 2013/09/01 Researcher (Research) Instituto de Medicina Molecular, Portugal
2009/02/01 - 2010/07/01 Researcher (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/09/01 - 2009/01/01 Research Trainee (Research) Vall d'Hebron Institut de Recerca, Spain

Teaching in Higher Education

Category
Host institution 		Employer
2025/01 - Current Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Others

Category
Host institution 		Employer
2013/09/01 - 2017/12/01 PhD Student University College of London, United Kingdom
The Francis Crick Institute, United Kingdom
2010/05/01 - 2011/12/01 Biologist TEAM Lda, Fun Science Portugal, Portugal
Projects

Grant

Designation Funders
2025/04/15 - Current CRISPR-Based Gene editing for Choroideremia
CRF Research Funding
Principal investigator
Fundação Champalimaud, Portugal
 Choroideremia Research Foundation (CRF)
Ongoing
2022/01/01 - 2023/12/31 The role of necroptosis in Choroideremia
EXPL/MED-OUT/0599/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2013/10/31 Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases
info:eu-repo/grantAgreement/EC/FP7/238316/EU
Instituto de Medicina Molecular, Portugal
 European Commission
Concluded
2008/01/01 - 2010/04/30 Elucidating the Critical Role of RNase II family of Enzymes in RNA metabolism: Structural and Functional Studies
info:eu-repo/grantAgreement/FCT/3599-PPCDT/71453/PT
Research Technician Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica
Concluded

Contract

Designation Funders
2025/02/01 - 2026/07/31 Is melanin protective in Age-related macular degeneration?
2023.12358.PEX
10.54499/2023.12358.PEX
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 A gene-editing nanoparticle formulation for retinal degeneration diseases
EXPL/BIA-CEL/0989/2021
10.54499/EXPL/BIA-CEL/0989/2021
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade Nova de Lisboa, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/04/01 - 2021/04/30 Lysosome dysfunction in age-related diseases
Project 30385 (IC&DT – AAC n.º 02/SAICT/2017)
Post-doc
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Miguel C. Seabra; Ana S. Falcão; Mafalda Lopes-da-Silva; ANTAS, PEDRO; Ana C. Fradinho; Luisa Lemos; Thomas Ciossek; et al. Corresponding author: Miguel C. Seabra. "TFEB-mediated reduction of autofluorescent granule load in retinal pigment epithelium". Paper presented in ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2022.
    Published
  2. Falcão AS; Escrevente, Cristina; ANTAS, PEDRO; Lopes-da-Silva, Mafalda; Ferreira, I.; Cardoso, MH; Tenreiro, S; Seabra, MC. "Dissecting the role of TFEB in autofluorescent granule load formation and degradation in retinal pigment epithelium". Paper presented in Cell Bio virtual 2021 - ASCB|EMBO meeting, 2021.
  3. Falcão AS; Cardoso Maria H; Hall, Michael; Escrevente C; ANTAS, PEDRO; Chaves-Ferreira M; Tenreiro S; Futter C; Seabra MC. "Dissecting the role of lysosome dysfunction in age-related macular degeneration". Paper presented in VII International DOG-Symposium on AMD, Baden-Baden, 2019.
    Published
  4. Nhacocane C; Escrevente C; Nogueira M; Piedade C; Ferreira I.; Cardoso MH; Chaves-Ferreira M; et al. "Dissecting the role of V-ATPase subuni isoforms on age-related macular degeneration". Paper presented in Lysocil workshop, Lisbon, 2019.
    Published
  5. Falcão AS; Cardoso MH; Hall M; Escrevente C; ANTAS, PEDRO; Chaves-Ferreira M; Tenreiro S; Futter CE; Seabra MC. "Exploring the role of lysosomal dysfunction in the pathogenesis of age-related macular degeneration". Paper presented in Ageing: Models, mechanisms and therapies, Coimbra, 2019.
    Published
  6. Tenreiro S; Cardoso MH; Hall M; Escrevente E; Falcão AS; ANTAS, PEDRO; Chaves-Ferreira M; Seabra MC. "Models of lysosomal dysfunction in retinal pigmented epithelium cells to study Age-related Macular Degeneration". Paper presented in COST Transautophagy: Annual Meeting, Sofia, 2019.
    Published
  7. Cardoso MH; Escrevente C; Falcão AS; Santos, G.; Hall M; Fradinho A; ANTAS, PEDRO; et al. "A synergistic approach to rejuvenate the retina and promote elderly vision". Paper presented in I International Conference | NOVAsaúde Ageing, Lisbon, 2018.
    Published
Conference paper
  1. Seabra MC; Helena MC; Hall M; Tenreiro S; Falcão AS; Escrevente C; ANTAS, PEDRO; Santos, G.; Futter C. "Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration". Paper presented in ARVO Annual Meeting, Vancouver, 2019.
    Published
  2. Tenreiro, S.; Reimao-Pinto, M. M.; Antas, P.; Rino, J.; Waiss, M.; Magalhaes, F.; Wawrzycka, D.; et al. "Harnessing the power of yeast to decipher the role of alpha-synuclein phosphorylation in Parkinson's disease". Paper presented in 26th International Conference on Yeast Genetics and Molecular Biology, 2013.
Conference poster
  1. de Lemos, Luísa; Antas, Pedro; Carvalho, Cláudia; Castro, Mariana; Fonseca, Ana F.; Bruno, Diogo; Seabra, Miguel C.. "Exploring low-cost non-viral mRNA delivery for inherited retinal diseases". Paper presented in Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, Seattle, WA, USA, 2024.
  2. Santos, Carolina; ANTAS, PEDRO; Miguel C. Seabra; Ferreira, Lino. Corresponding author: Santos, Carolina. "Gene editing nanoparticle for choroideremia". Paper presented in 3rd RESETageing Conference, 2023.
  3. ANTAS, PEDRO; Seabra, MC. "Genome Editing of induced Pluripotent Stem Cells using CRISPR/Cas to model Choroideremia Disease". Paper presented in XXth INTERNATIONAL SYMPOSIUM ON RETINAL DEGENERATION RD2023, 2023.
  4. Ana S Falcão; Margarida Pedro; ANTAS, PEDRO; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Using CRISPR/Cas9 to knock-out the NRF2 gene in retinal pigment epithelium cells.". Paper presented in 5th-BenBedPhar-meeting (COST ACTION 20121), Graz, Austria, 2023.
  5. Santos, Carolina; Antas, Pedro; Seabra, MC; Ferreira, Lino. Corresponding author: Santos, Carolina. "A Gene Editing Formulation For Retinal Degenerative Diseases". Paper presented in European Tissue Repair Society (ETRS) & Portuguese Society of Stem Cells and Cell Therapies (SPCE-TC), 2023.
  6. de Lemos, Luisa; ANTAS, PEDRO; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "3D human retinal organoid model for the study of early diabetic retinopathy". Paper presented in 2nd Microphysiological Systems World Summit, 2023.
  7. de Lemos, Luísa; ANTAS, PEDRO; Mariana Castro; Ana Fonseca; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Non-viral mRNA delivery in 3D human eye cell models". Paper presented in CorEuStem symposium, Champalimaud, Lisbon, Portugal, 2023.
  8. Fonseca, Ana; ANTAS, PEDRO; Seabra, MC. "Mechanisms of Cell Death in Choroideremia". Paper presented in NMS PhD Retreat 2022, 2022.
  9. Luísa Lemos; ANTAS, PEDRO; Inês Santos; Miguel Ferreira; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degeneration by hyperglycemia using 3D human organoids". Paper presented in Organoids With]Out[ Borders Online symposium, 2020.
  10. Luísa Lemos; ANTAS, PEDRO; Inês Ferreira; Daniela Dias; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degeneration by hyperglycemia and oxidative stress using 3D human organoids.". Paper presented in EMBO|EMBL Symposium: Organoids: Modeling Organ development and disease in 3D cell culture., 2020.
  11. Luísa Lemos; Antas, Pedro; Inês Ferreira; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degenerative diseases with 3D human organoids.". Paper presented in EMBO Workshop Proteostasis: From organelles to organims., 2019.
  12. Inês Ferreira; Luísa Lemos; ANTAS, PEDRO; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "3D human retinal organoids as a model for dissecting retinal disease microenvironment.". Paper presented in Champalimaud Research Symposium ¿Tissue Environment in Heath and Disease, 2019.
  13. de Lemos, Luisa; ANTAS, PEDRO; Ferreira, Ines; Seabra, Miguel; Tenreiro, Sandra. "Modeling retinal degenerative diseases with 3D-human retinal organoids.". Paper presented in Ageing: Models, mechanisms and therapies, 2019.
  14. Tenreiro, Sandra; Cardoso, MH; Hall, Michael; Escrevente, Cristina; Falcão, Sofia; ANTAS, PEDRO; Chaves-Ferreira, Miguel; et al. "Lysosomal dysfunction in the retinal pigmented epithelium and the pathogenesis of age-related macular degeneration.". Paper presented in ARVO Conference 2019. Baltimore, USA, 2019.
  15. Tenreiro, Sandra; Cardoso, MH; Hall, Michael; Falcão, Sofia; ANTAS, PEDRO; Chaves-Ferreira, Miguel; Futter, CE; et al. "Emerging insights on pathogenesis of early age-related macular degeneration by modelling lysosome dysfunction". Paper presented in Nature Conference: Ageing, Health & Rejuvenation Rotterdam, The Netherlands, 2019.
  16. Novellasdemunt, Laura; Foglizzo, Valentina; Cuadrado, Laura; ANTAS, PEDRO; Kucharska, Anna; Encheva, Vesela; Snijders, Ambrosius P.; Li, Vivian S. W.. "USP7 is a tumour-specific WNT activator for APC-mutated colorectal cancer by mediating ß -catenin deubiquitination.". Paper presented in European Wnt meeting, 2018.
  17. Novellasdemunt, Laura; Foglizzo, Valentina; Cuadradro, Laura; ANTAS, PEDRO; Kucharska, Anna; Encheva, Vesela; Snijders, Ambrosius P.; Vivian Li. "USP7 is a tumour-specific WNT activator for APC-mutated colorectal cancer by mediating b-catenin deubiquitination". Paper presented in European Wnt meeting, Heidelberg, Germany, 2018.
  18. ANTAS, PEDRO. "The ZAK kinase is a negative regulator of Wnt/ß-catenin signalling". Paper presented in Gordon Research Conferences: Wnt signalling, 2017.
  19. Novellasdemunt, Laura; Foglizzo, Valentina; Caudrado, Laura; ANTAS, PEDRO; Kucharska, Anna; Encheva, Vesela; Snijders, Ambrosius P.; Li, Vivian SW. "USP7 is a tumour-specific WNT activator for APC-mutated colorectal cancer by mediating b-catenin deubiquitination.". Paper presented in Wnt signalling, Gordon Research Conference. Stoke, US, 2017.
  20. Miller-Fleming, Leonor; ANTAS, PEDRO; Teresa Pais; Smalley, J; Gant, T; Giorgini, Flaviano; Tiago Outeiro. "New insights into the function of the yeast homologues of DJ-1, a protein associated with Parkinson's disease". Paper presented in 3rd Parkinson’s UK Research Conference, York, UK, 2012.
Journal article
  1. Fonseca, Ana Fragoso; Coelho, Rita; da-Silva, Mafalda Lopes-; Lemos, Luísa; Hall, Michael J.; Oliveira, Daniela; Falcão, Ana Sofia; et al. Corresponding author: Antas, Pedro. "Modeling Choroideremia Disease with Isogenic Induced Pluripotent Stem Cells". Stem Cells and Development 33 19-20 (2024): 528-539. https://doi.org/10.1089/scd.2024.0105.
    10.1089/scd.2024.0105
  2. de Lemos, Luisa; Antas, Pedro; Ferreira, Inês S.; Santos, Inês Paz; Felgueiras, Beatriz; Gomes, Catarina M.; Brito, Catarina; Seabra, Miguel C.; Tenreiro, Sandra. "Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids". In vitro models 3 1 (2024): 33-48. https://doi.org/10.1007/s44164-024-00068-1.
    10.1007/s44164-024-00068-1
  3. Pedro Antas; Cláudia Carvalho; Joaquim Cabral-Teixeira; Luísa de Lemos; Miguel C. Seabra. Corresponding author: Pedro Antas. "Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases". Trends in Molecular Medicine (2024): https://doi.org/10.1016/j.molmed.2023.11.009.
    10.1016/j.molmed.2023.11.009
  4. Antas, Pedro; Cleveland, Abigail; Contessotto, Paolo; Schaffrath, Raffael. "Science around the world". Trends in Molecular Medicine 30 2 (2024): 107-109. https://doi.org/10.1016/j.molmed.2023.12.007.
    Published • 10.1016/j.molmed.2023.12.007
  5. Carvalho, Cláudia; Lemos, Luísa; Antas, Pedro; Seabra, Miguel C.. Corresponding author: Antas, Pedro. "Gene therapy for inherited retinal diseases: exploiting new tools in genome editing and nanotechnology". Frontiers in Ophthalmology 3 (2023): http://dx.doi.org/10.3389/fopht.2023.1270561.
    10.3389/fopht.2023.1270561
  6. Cardoso, M. Helena; Hall, Michael J.; Burgoyne, Thomas; Fale, Pedro; Storm, Tina; Escrevente, Cristina; Antas, Pedro; Seabra, Miguel C.; Futter, Clare E.. "Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells". Investigative Opthalmology & Visual Science 64 11 (2023): 10. https://doi.org/10.1167/iovs.64.11.10.
    10.1167/iovs.64.11.10
  7. Nordgaard, Cathrine; Vind, Anna Constance; Stonadge, Amy; Kjøbsted, Rasmus; Snieckute, Goda; Antas, Pedro; Blasius, Melanie; et al. "ZAKß is activated by cellular compression and mediates contraction-induced kinase signaling in skeletal muscle". The EMBO Journal (2022): http://dx.doi.org/10.15252/embj.2022111650.
    Published • 10.15252/embj.2022111650
  8. Escrevente, Cristina; Falcão, Ana S.; Hall, Michael J.; Lopes-da-Silva, Mafalda; Antas, Pedro; Mesquita, Miguel M.; Ferreira, Inês S.; et al. "Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction". Investigative Opthalmology & Visual Science 62 9 (2021): 39. http://dx.doi.org/10.1167/iovs.62.9.39.
    Published • 10.1167/iovs.62.9.39
  9. Guillermin, Oriane; Angelis, Nikolaos; Sidor, Clara M; Ridgway, Rachel; Baulies, Anna; Kucharska, Anna; Antas, Pedro; et al. "Wnt and Src signals converge on YAP-TEAD to drive intestinal regeneration". The EMBO Journal (2021): http://dx.doi.org/10.15252/embj.2020105770.
    Published • 10.15252/embj.2020105770
  10. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)". Autophagy 17 1 (2021): 1-382. https://doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  11. Novellasdemunt, Laura; Kucharska, Anna; Jamieson, Cara; Prange-Barczynska, Maria; Baulies, Anna; ANTAS, PEDRO; van der Vaart, Jelte; et al. "NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor". The EMBO Journal 39 3 (2019): http://dx.doi.org/10.15252/embj.2019102771.
    Published • 10.15252/embj.2019102771
  12. Ferreira, Carla; Couceiro, Joana; Família, Carlos; Jardim, Carolina; ANTAS, PEDRO; Santos, Cláudia N; Outeiro, Tiago F; Tenreiro, Sandra; Quintas, Alexandre. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research 19 5 (2019): http://dx.doi.org/10.1093/femsyr/foz042.
    Published • 10.1093/femsyr/foz042
  13. Antas, Pedro; Novellasdemunt, Laura; Kucharska, Anna; Massie, Isobel; Carvalho, Joana; Oukrif, Dahmane; Nye, Emma; Novelli, Marco; Li, Vivian S.W.. "SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating ß-Catenin Nuclear Localization". Cell Reports 26 9 (2019): 2266-2273.e4. http://dx.doi.org/10.1016/j.celrep.2019.01.110.
    Published • 10.1016/j.celrep.2019.01.110
  14. de Oliveira, Rita Machado; Vicente Miranda, Hugo; Francelle, Laetitia; Pinho, Raquel; Szegö, Éva M.; Martinho, Renato; Munari, Francesca; et al. "The mechanism of sirtuin 2 mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease". PLOS Biology 15 3 (2017): e2000374. http://dx.doi.org/10.1371/journal.pbio.2000374.
    Published • 10.1371/journal.pbio.2000374
  15. Novellasdemunt, Laura; Foglizzo, Valentina; Cuadrado, Laura; Antas, Pedro; Kucharska, Anna; Encheva, Vesela; Snijders, Ambrosius P.; Li, Vivian S. W.. "USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating beta-Catenin Deubiquitination". Cell Reports 21 3 (2017): 612-627.
    Published • 10.1016/j.celrep.2017.09.072
  16. ANTAS, PEDRO; Novellasdemunt, Laura; Li, Vivian S. W.. "Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms". American Journal of Physiology-Cell Physiology 309 8 (2015): C511-C521. http://dx.doi.org/10.1152/ajpcell.00117.2015.
    Published • 10.1152/ajpcell.00117.2015
  17. Tenreiro, Sandra; Reimão-Pinto, Madalena M.; ANTAS, PEDRO; Rino, José; Wawrzycka, Donata; Macedo, Diana; Rosado-Ramos, Rita; et al. "Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease". PLoS Genetics 10 5 (2014): e1004302. http://dx.doi.org/10.1371/journal.pgen.1004302.
    Published • 10.1371/journal.pgen.1004302
  18. Miller-Fleming, L.; ANTAS, PEDRO; Pais, T. F.; Smalley, J. L.; Giorgini, F.; Outeiro, T. F.. "Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase". Proceedings of the National Academy of Sciences 111 19 (2014): 7012-7017. http://dx.doi.org/10.1073/pnas.1319221111.
    10.1073/pnas.1319221111
  19. Miller-Fleming, Leonor; Cheong, Heesun; ANTAS, PEDRO; Klionsky, Daniel J.. "Detection of Saccharomyces cerevisiae Atg13 by western blot". Autophagy 10 3 (2014): 514-517. 10.4161/auto.27707.
    Published • 10.4161/auto.27707
  20. ANTAS, PEDRO; Basso, Elisa; Marijanovic, Zrinka; Gonçalves, Susana; Tenreiro, Sandra; Outeiro, Tiago Fleming. "PLK2 Modulates a-Synuclein Aggregation in Yeast and Mammalian Cells". Molecular Neurobiology 48 3 (2013): 854-862. http://dx.doi.org/10.1007/s12035-013-8473-z.
    10.1007/s12035-013-8473-z
  21. Pais, T. F.; Szego, E. M.; Marques, O.; Miller-Fleming, L.; ANTAS, PEDRO; Guerreiro, P.; de Oliveira, R. M.; Kasapoglu, B.; Outeiro, T. F.. "The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation". Embo Journal 32 19 (2013): 2603-2616. 10.1038/emboj.2013.200.
    Published • 10.1038/emboj.2013.200
Preprint
  1. Ana S Falcão; Mafalda Lopes-da-Silva; Pedro Antas; Cristina Escrevente; Margarida Pedro; Rita Coelho; Inês S Ferreira; et al. "Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration". 2024. https://doi.org/10.1101/2024.09.17.613413.
    10.1101/2024.09.17.613413
Thesis / Dissertation
  1. ANTAS, PEDRO. "Identification and characterisation of novel Wnt regulators in colorectal cancer". PhD, University College of London, 2017. https://discovery.ucl.ac.uk/id/eprint/10040333/.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2012 PLK2 mediated phosphorylation on Ser-129 Induces Alpha-Synuclein Aggregation XIX Congress of Yeast Biology “Professor Nicolau Van Uden”
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09/01 - Current Mechanisms of Cell Death in Choroideremia
Supervisor
2023/03 - 2024/04 Non-viral mRNA therapy for inherited retinal diseases
Supervisor
 Biomedical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2022/01/17 iPS cell modeling of choroideremia disease: insights into trafficking pathways and necroptosis
Supervisor of Daniela Filipa Colaço de Oliveira
 Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2021/03/05 Purification and characterization of dysfunctional lysosomes in an age-related macular degeneration cell model
Supervisor of Miguel Ângelo Martins Mesquita
 Biomedical Research (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/09 A gene editing nanoparticle formulation for retinal degenerative diseases
(Thesis) Main arguer
 Carolina Marques dos Santos (Other)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/06/30 Identification of the lysosomal transcription factors involved in lysosome dysfunction in cells (macrophages) exposed to oxidized lipids
(Thesis) Arguer
 Ana Catarina Sousa Calheta (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/03/26 Genome editing to be applied in functional characterization of genetic variants in familial breast cancer patient
(Thesis) Main arguer
 Ana Rita Serra Pedro (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Association member

Society Organization name Role
2016/06 - 2017/06 PARSUK-Portuguese Association of Researchers and Students in the United Kingdom President
2015/06 - 2016/06 PARSUK-Portuguese Association of Researchers and Students in the United Kingdom President of The General Assembly

Committee member

Activity description
Role 		Institution / Organization
2019/10 - Current The Ethics Committee of ESSCVP is an advisory body composed of several expert members on ethical issues in the areas of education, scientific research and institutional operation. The EC is responsible for applying the general principles and practical guidelines described in the Code of Ethical Conduct and in accordance with national and international law.
Member
 Escola Superior de Saúde da Cruz Vermelha Portuguesa, Portugal

Consulting

Activity description Institution / Organization
2016/09/01 - 2016/12/31 Science Police Adviser Intern at the Royal Society Science Policy Centre which provides independent and authoritative scientific advice to the UK, European and international decision-makers.

Mentoring / Tutoring

Topic Student name
2022/07/04 - 2022/07/08 The role of necroptosis in Choroideremia Bruno Lopes
2020/02/24 - 2020/03/20 Generation of a genetic model of Lysosomal Dysfunction César Cunha
2019/02/13 - 2019/03/15 CRISPR/Cas9 knock-in strategy for purifying lysosomes Miguel Mesquita
Distinctions

Award

2023 Throssell and Hillier Families Research Award
Choroideremia Research Foundation (CRF) , United States
2020 Stimulus of Scientific Employment, Individual Support (CEECIND) - 3rd Edition
Fundação para a Ciência e a Tecnologia, Portugal
2015 Science Policy Internship fellowship at The Royal Society
Research Council United Kingdom, United Kingdom
2013 PhD fellowship
Medical Research Council, United Kingdom

The Francis Crick Institute, United Kingdom