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Ana Sofia Iria Azeredo Falcão de Jesus completed her PhD in Pharmacy in 2006/09/18 by Universidade de Lisboa and graduation in Pharmaceutical Sciences in 2002/03/31 by Universidade de Lisboa Faculdade de Farmácia. Published 35 articles in journals and 5 book chapters. h-Index=24, with Sum of times cited=1601. Organized 10 event(s). Co-supervised 2 PhD thesis(es). Supervised 2 MSc dissertation(s) and co-supervised 12. Has received 11 awards and/or honors. Participates and/or participated as PhD Student Fellow in 4 project(s), Pos-doctoral Fellow in 3 project(s) and as a Researcher in 11 projects (2 as co-PI). Guest Associate Editor in Frontiers Neuropharmacology. Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine. At NOVA Medical School, became interested in exploring new biomarkers and innovative therapeutic approaches for neurodegenerative disorders or other age-related diseases, such as age-related macular degeneration. Focused in in vitro and in vivo models to study retinal diseases that will be used for fundamental studies as well as for potential translational applications to treat retinal degeneration.
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Identification

Personal identification

Full name
Ana Sofia Iria Azeredo Falcão de Jesus

Citation names

  • Falcão AS

Author identifiers

Ciência ID
EC17-1F25-9969
ORCID iD
0000-0002-4491-7457
Researcher Id
M-5600-2013
Scopus Author Id
8896201400

Email addresses

  • ana.falcao@nms.unl.pt (Professional)

Telephones

Telephone
  • 218 803105 (Professional)

Addresses

  • Chronic Diseases Research Center (CEDOC), Nova Medical School, Universidade Nova de Lisboa Rua Câmara Pestana, nº 6, 1150-082, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Italian Elementary (A2) Elementary (A2) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2023 - 2023
Concluded
 Course on Laboratory Animal Sciences for designing projects and procedures (Upgrade to Function B, accredited by FELASA) (Outros)
Instituto Gulbenkian de Ciência, Portugal
2018/10/01 - 2018/10/04
Concluded
 Course on Laboratory Animal Sciences in Mouse and Zebrafish (EU Functions A+D, accredited by FELASA) (Outros)
Instituto Gulbenkian de Ciência, Portugal
2006/09/18
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Biologia Geral e Celular
Universidade de Lisboa, Portugal
"New Findings on Neuropathological Effects of Hyperbilirubinemia in Astrocytes and Neurons - Evaluation of Cell Susceptibilities and of Neuritic Development" (THESIS/DISSERTATION)
 Approved with laude and honor
1996/10/01 - 2002/03/31
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2023/04/01 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/03/01 - 2021/08/31 Contracted Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2017/11/01 - 2019/10/30 Contracted Researcher (Research) iNOVA4Health, Portugal
2017/05/15 - 2017/10/31 Postdoc (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/10/01 - 2016/09/30 Research Assistant (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/10/01 - 2012/09/30 Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/06/15 - 2009/06/30 Postdoc (Research) Università degli Studi di Trieste, Italy
Università degli Studi di Trieste, Italy
2004/09/01 - 2004/10/07 Research Trainee (Research) Università degli Studi di Trieste, Italy
Università degli Studi di Trieste, Italy
2002/04/01 - 2002/06/30 Research Trainee (Research) Università degli Studi di Bologna, Italy
Università degli Studi di Bologna, Italy

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2017 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2002/10/01 - 2006/09/30 PhD student Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
1998/01/01 - 2001/06/30 Trainee student Universidade de Lisboa Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
2025/02/01 - 2026/07/31 Is melanin protective in Age-related macular degeneration?
2023.12358.PEX
10.54499/2023.12358.PEX
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/10 - 2016/09 Applying NSC Biology to Glioma research - Ciência 2007
C2007-FFUL/UBMBE/02/2011
Researcher
Fundação para a Ciência e Tecnologia
Concluded

Contract

Designation Funders
2023/09/01 - Current Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
10.54499/LA/P/0087/2020
Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal

Universidade Nova de Lisboa, Portugal

GREEN-IT, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Centro de Estudos Comparatistas, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/12/01 - Current NRF2 as a novel therapeutic target in early and intermediate age-related macular degeneration
HR22-00569
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Ongoing
2022/01/01 - Current Co-PI: The role of necroptosis in Choroideremia (50Keuros)
EXPL/MED-OUT/0599/2021
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Ongoing
2018/10/01 - 2022 Lysosome dysfunction in age-related diseases
PTDC/MED-PAT/30385/2017
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e Tecnologia
Concluded
2018/10/01 - 2022 Recovering neuronal function and promoting neuroprotection in diabetic retinopathy
PTDC/MED-PAT/29656/2017
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/05/08 - 2020/05/07 Bioengineered in vitro model of retinal pigmented epithelium of human eye
M-ERA-NET2/0005/2016
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2020 Mechanisms of Cell Death in Choroideremia
no code
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Choroideremia Research Foundation
Concluded
2017/11/01 - 2019/11/30 Co-PI: Correction of lysosomal dysfunction in RPE cells (325 Keuros)
no code
Researcher
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Boehringer Ingelheim Europe GmbH
Concluded
2016/01/01 - 2018/12/31 Generation of Improved cellular and animal Models for identification of disease phenotype and new therapeutic targets of Alzheimer’s Disease
JPCOFUND/0003/2015
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2016/01/01 - 2018/12/01 Identification and assessment of new psychoactive substances: a European network
JUST/2014/JDRUG/AG/DRUG
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2014/03/01 - 2017/05/01 Decoding the regulation of microglia phenotype by microRNAs in Alzheimer's Disease
info:eu-repo/grantAgreement/FCT/3599-PPCDT/134028/PT
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/01/16 - 2015/07/14 ARE MICROGLIA A NEW POTENTIAL PHARMACOLOGICAL TARGET IN AMYOTROPHIC LATERAL SCLEROSIS (ALS)?
info:eu-repo/grantAgreement/FCT/3599-PPCDT/118787/PT
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2011/04/30 Study of the blood-brain barrier disruption by neurotoxins and modulation by therapeutic agents in a human model: effects of bilirubin and endotoxin on brain microvascular endothelial cell monolayer integrity and protective role of bile acids
info:eu-repo/grantAgreement/FCT/3599-PPCDT/68819/PT
Post-doc Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation
info:eu-repo/grantAgreement/FCT/3599-PPCDT/64385/PT
Post-doc Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2009/07/14 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
info:eu-repo/grantAgreement/FCT/3599-PPCDT/82303/PT
Post-doc Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2002/09/01 - 2005/09/01 Inflammatory response and signaling between neurons and astrocytes during cell injury by sepsis, hypoxia-ischemia and hyperbilirrubinemia
POCTI/39906/FCT/2001
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004/01/01 - 2005/01/01 Evaluation of ibuprofen vs. Indomethacin on unconjugated bilirubin detrimental effects in rat astrocyte cultures
IBU/BILIPARACLIN/04
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Orphan Europe SARL
Concluded
2003/01/01 - 2004/01/01 Evaluation of UCB-induced oxidative stress in astrocytes
PROJECTO 344/03
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação Luso-Americana
Concluded
2003/01/01 - 2004/01/01 Is bilirubin-induced apoptosis of nerve cells mediated through TNF-alpha receptor 1?
FCG-ESTIMULO2002-10-56693-S
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação Calouste Gulbenkian
Concluded
Outputs

Publications

Book chapter
  1. Falcão AS; Gomes, C.; Brites, Dora. Corresponding author: Falcão AS. "Role of ABC transporters in the regulation of neural stem cell biology: implications on CNS diseases". In Neurogenesis: Cell Biology, Regulation and Role in Disease, 77-112. Nova Science Publishers, 2015.
    Published
  2. Brites, Dora; Gomes, C.; Pinheiro, Rui; Falcão AS. "New insights in the pro- and anti-neurogenic interventions of microglia and their association to gliomas". In Microglia: Physiology, Regulation and Health Implications, 67-111. Nova Science Publishers, 2015.
    Published
  3. Brites, D.; Fernandes, A.; Falcão, A. S.; Brito, M. A.; Silva, R F. M.. "Glial and Neuronal Reactivity to Unconjugated Bilirubin". In Encyclopedia of Neuroscience, 1726-1730. Germany: Springer Berlin Heidelberg, 2009.
    Published • 10.1007/978-3-540-29678-2_2003
  4. Brito MA; Rosa AI; Silva, RFM; Falcão AS; Fernandes, Adelaide; Brites, Dora. "Oxidative stress and disruption of the nervous cell". In Focus in Brain Research, 1-33. United States: Nova Science Publishers Inc., 2007.
    Published
  5. Silva, RFM; Brito MA; Falcão AS; Fernandes, Adelaide; Gordo, C; Brites, Dora. "Nerve cell cultures as models for assessment of pollutant cytotoxicity". In Bulletin of the Transilvania University of Brasov, 160-167. Romania: Transilvania University Press, 2005.
    Published
Conference abstract
  1. Margarida Pedro; Falcão AS; Rita Coelho; Lopes da Silva, Mafalda; Tenreiro, Sandra; Seabra, MC. "Assessment of transcription factors nuclear translocation in stimulated human RPE cells by microscopy imaging". Paper presented in The Spanish and Portuguese Advanced Optical Microscopy Meeting (SPAOM2023), Faro, 2023.
    Published • 10.5281/zenodo.10401087
  2. Falcão AS; Margarida Pedro; ANTAS, PEDRO; Tenreiro, Sandra; Seabra, MC. "Using CRISPR/Cas9 to knock-out the NRF2 gene in retinal pigment epithelium cells". Paper presented in 5th COST BenBedPhar conference- Translating NRF2 research into clinical practice, Graz, 2023.
    Published • 10.5281/zenodo.10401119
  3. Brodsky K; Petránková B; Petrásková L; Falcão AS; Nunes dos Santos, Cláudia; Seabra, MC; Valentová K. "Polyphenols and their sulfated derivatives as molecular signaling modulators". Paper presented in 4th International Conference on food bioactives and health, Prague, 2023.
    Published
  4. Vicente Miguel ; Falcão AS; Margarida Pedro; Tomás Guerreiro ; Seabra, MC; Tenreiro, Sandra. "Effect of repurposed drugs on autofluorescent granule accumulation in a cellular model of age-related macular degeneration.". Paper presented in 4th COST BenBedPhar conference, zagreb, 2023.
    Published
  5. Falcão AS; Escrevente, Cristina; ANTAS, PEDRO; Lopes-da-Silva, Mafalda; Ferreira, I.; Cardoso, MH; Tenreiro, S; Seabra, MC. "Dissecting the role of TFEB in autofluorescent granule load formation and degradation in retinal pigment epithelium". Paper presented in Cell Bio virtual 2021 - ASCB|EMBO meeting, 2021.
  6. Lopes-da-Silva, Mafalda; Falcão AS; Escrevente C; Tenreiro, Sandra; Miguel C. Seabra. "Using CLEM to unravel intracellular membrane trafficking defects". Paper presented in SPAOM Spanish and Portugues Advanced Optical Microscopy meeting, coimbra, 2020.
    Published
  7. Falcão AS; Cardoso Maria H; Hall, Michael; Escrevente C; ANTAS, PEDRO; Chaves-Ferreira M; Tenreiro S; Futter C; Seabra MC. "Dissecting the role of lysosome dysfunction in age-related macular degeneration". Paper presented in VII International DOG-Symposium on AMD, Baden-Baden, 2019.
    Published
  8. Escrevente C; Falcão AS; Cardoso MH; Ferreira I.; Tenreiro S; Seabra MC. "Unravelling the role of lysosome dysfunction in the pathogenesis of age-related macular degeneration". Paper presented in Lysocil workshop, Lisbon, 2019.
    Published
  9. Nhacocane C; Escrevente C; Nogueira M; Piedade C; Ferreira I.; Cardoso MH; Chaves-Ferreira M; et al. "Dissecting the role of V-ATPase subuni isoforms on age-related macular degeneration". Paper presented in Lysocil workshop, Lisbon, 2019.
    Published
  10. Falcão AS; Cardoso MH; Hall M; Escrevente C; ANTAS, PEDRO; Chaves-Ferreira M; Tenreiro S; Futter CE; Seabra MC. "Exploring the role of lysosomal dysfunction in the pathogenesis of age-related macular degeneration". Paper presented in Ageing: Models, mechanisms and therapies, Coimbra, 2019.
    Published
  11. Tenreiro S; Cardoso MH; Hall M; Falcão AS; ANTAS, PEDRO; Chaves-Ferreira M; Futter C; Seabra MC. "Emerging insights on pathogenesis of early age-related macular degeneration by modelling lysosome dysfunction". Paper presented in Nature Congerence: Ageing, Health & Rejuvenation, Rotterdam, 2019.
    Published
  12. Tenreiro S; Cardoso MH; Hall M; Escrevente E; Falcão AS; ANTAS, PEDRO; Chaves-Ferreira M; Seabra MC. "Models of lysosomal dysfunction in retinal pigmented epithelium cells to study Age-related Macular Degeneration". Paper presented in COST Transautophagy: Annual Meeting, Sofia, 2019.
    Published
  13. Hall M; Cardoso MH; Falcão AS; Escrevente C; Tenreiro S; Seabra MC; Futter C. "Modelling lysosome dysfunction in the retinal pigment epithelium in the development of early Age-related Macular Degeneration". Paper presented in Gordon Research Conference on Lysosomal Diseases, Galveston, 2019.
    Published
  14. Falcão AS; Escrevente C; Cardoso MH; Santos, G.; Tenreiro S; Seabra MC. "Lysosome dysfunction in the retinal pigment epithelium (RPE) and the pathogenesis of age-related macular degeneration (AMD)". Paper presented in CEDOC Symposium, Lisbon, 2018.
    Submitted
  15. Cardoso MH; Hall M; Falcão AS; Escrevente C; Santos, G.; Tenreiro S; Futter C; Seabra MC. "Aging in the Retina: hESc-derived Retinal Pigment Epithelium model of chronic lysosomal dysfunction". Paper presented in Cell Aging and Metabolism, Stiges, 2018.
    Published
  16. Cardoso MH; Escrevente C; Falcão AS; Santos, G.; Hall M; Fradinho A; ANTAS, PEDRO; et al. "A synergistic approach to rejuvenate the retina and promote elderly vision". Paper presented in I International Conference | NOVAsaúde Ageing, Lisbon, 2018.
    Published
  17. Tenreiro S; Cardoso MH; Hall M; Falcão AS; Escrevente C; Futter C; Seabra MC. "Lysosomal dysfunction in the retinal pigmented epithelium and the pathogenesis of age-related macular degeneration". Paper presented in 2nd Small Meeting on Endocytic Trafficking and Signaling, 2018.
    Published
  18. Hall M; Falcão AS; Cardoso MH; Escrevente C; Santos, G.; Tenreiro S; Futter C; Seabra MC. "Lysosomal dysfunction in the retinal pigmented epithelium and the pathogenesis of age-related macular degeneration". Paper presented in Gordon Research Conference on Lysosomes and Endocytosis, Lisbon, 2018.
    Published
  19. Cardoso MH; Hall M; Falcão AS; Escrevente C; Tenreiro S; Futter C; Seabra MC. "hESc-derived RPE model of chronic lysosome dysfunction". Paper presented in Embo Lysosomes and Metabolism Workshop, Naples, 2018.
    Published
  20. Falcão AS; Escrevente C; Cardoso MH; Santos, G.; Tenreiro S; Seabra MC. "Using photoreceptor outer segments autofluorescence to measure lysosomal dysfunction in pig and human retinal pigmented epithelial cells". Paper presented in Embo Lysosomes and Metabolism Workshop, Naples, 2018.
    Published
  21. Hall M; Cardoso MH; Falcão AS; Escrevente C; Tenreiro S; Seabra MC; Futter C. "Modelling lysosome dysfunction in the retinal pigment epithelium in the development of early AMD". Paper presented in Institute of Ophthalmology Meeting, London, 2018.
    Published
Conference paper
  1. Falcão AS; Margarida Pedro; Vicente Miguel ; Rita Coelho; Tenreiro, S; Seabra, MC. "NRF2 as a therapeutic target in early and intermediate age-related macular degeneration". Paper presented in 8th International Symposium on Age-related Macular Degeneration, Baden Baden, 2023.
  2. Seabra MC; Helena MC; Hall M; Tenreiro S; Falcão AS; Escrevente C; ANTAS, PEDRO; Santos, G.; Futter C. "Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration". Paper presented in ARVO Annual Meeting, Vancouver, 2019.
    Published
  3. Fernandes, A.; Caldeira, C.; Falcao, A. S.; Cunha, C.; Vaz, A. R.; Brites, D.. "Temporal gene expression profile related to microglia reactivity in 3xTgAD mice". 2015.
Journal article
  1. Rojo, Ana I.; Buttari, Brigitta; Cadenas, Susana; Carlos, Ana Rita; Cuadrado, Antonio; Falcão, Ana Sofia; López, Manuela G.; et al. "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.". Redox Biology (2024): 103464. https://doi.org/10.1016/j.redox.2024.103464.
    Open access • In press • 10.1016/j.redox.2024.103464
  2. Fonseca, Ana Fragoso; Coelho, Rita; da-Silva, Mafalda Lopes-; Lemos, Luísa; Hall, Michael J.; Oliveira, Daniela; Falcão, Ana Sofia; et al. "Modeling Choroideremia Disease with Isogenic Induced Pluripotent Stem Cells". Stem Cells and Development 33 19-20 (2024): 528-539. https://doi.org/10.1089/scd.2024.0105.
    Open access • Published • 10.1089/scd.2024.0105
  3. Vaz, Ana Rita; Falcão AS; Palomo, Valle. "Editorial: Neurodegeneration, cell signaling and neuroreparative strategies, Volume II". Frontiers in Pharmacology 14 (2023): http://dx.doi.org/10.3389/fphar.2023.1198151.
    10.3389/fphar.2023.1198151
  4. Vaz, Ana Rita; Falcão AS; Palomo, Valle. "Editorial: Neurodegeneration, cell signaling and neuroreparative strategies". Frontiers in Pharmacology 13 (2022): http://dx.doi.org/10.3389/fphar.2022.1059923.
    10.3389/fphar.2022.1059923
  5. Escrevente, Cristina; Falcão AS; Hall, Michael J.; Lopes-da-Silva, Mafalda; Antas, Pedro; Mesquita, Miguel M.; Ferreira, Inês S.; et al. "Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction". Investigative Opthalmology & Visual Science 62 9 (2021): 39. http://dx.doi.org/10.1167/iovs.62.9.39.
    10.1167/iovs.62.9.39
  6. Vaz, Ana Rita; Falcão AS; Scarpa, Eleonora; Semproni, Carlotta; Brites, Dora. "Microglia Susceptibility to Free Bilirubin Is Age-Dependent". Frontiers in Pharmacology 11 (2020): http://dx.doi.org/10.3389/fphar.2020.01012.
    Open access • Published • 10.3389/fphar.2020.01012
  7. Caldeira, Cláudia; Cunha, Carolina; Vaz, Ana R.; Falcão, Ana S.; Barateiro, Andreia; Seixas, Elsa; Fernandes, Adelaide; Brites, Dora. "Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation". Frontiers in Aging Neuroscience 9 (2017): http://dx.doi.org/10.3389/fnagi.2017.00277.
    10.3389/fnagi.2017.00277
  8. Pinheiro, Rui; Braga, Claudia; Santos, Gisela; Bronze, Maria R.; Perry, Maria J.; Moreira, Rui; Brites, Dora; Falcão AS. Corresponding author: Falcão AS. "Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?". Acs Chemical Neuroscience 8 1 (2017): 50-59. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392459400009&KeyUID=WOS:000392459400009.
    10.1021/acschemneuro.6b00169
  9. Falcao, Ana S.; Carvalho, Luis A. R.; Lidonio, Goncalo; Vaz, Ana R.; Lucas, Susana D.; Moreira, Rui; Britrs, Dora. "Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in A beta-Mediated Microglial Inflammation". Acs Chemical Neuroscience 8 1 (2017): 89-99. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392459400013&KeyUID=WOS:000392459400013.
    10.1021/acschemneuro.6b00250
  10. Gomes, Catia; Santos, Gisela; Falcão AS; Brites, Dora. Corresponding author: Falcão AS. "Early Differentiating Mouse Astroglial Progenitors Share Common Protein Signatures with GL261 Glioma Cells". Journal of Stem Celll and Regenerative Biology 2 2 (2016): 1-15. http://dx.doi.org/10.15436/2471-0598.16.014.
    Published • 10.15436/2471-0598.16.014
  11. Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Gomes, C.; Fernandes, A.; Barateiro, A.; Tiribelli, C.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Adverse secondary impacts". Neurotoxicity Research 26 1 (2014): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903741375&partnerID=MN8TOARS.
    10.1007/s12640-013-9427-y
  12. Caldeira, C.; Oliveira, A.F.; Cunha, C.; Vaz, A.R.; Falcão, A.S.; Fernandes, A.; Brites, D.. "Microglia change from a reactive to an age-like phenotype with the time in culture". Frontiers in Cellular Neuroscience 8 JUN (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901848126&partnerID=MN8TOARS.
    10.3389/fncel.2014.00152
  13. Torrado, E.F.; Gomes, C.; Santos, G.; Fernandes, A.; Brites, D.; Falcão AS. Corresponding author: Falcão AS. "Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population". International Journal of Developmental Neuroscience 37 (2014): 94-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905379941&partnerID=MN8TOARS.
    10.1016/j.ijdevneu.2014.07.001
  14. Mariano, C.; Palmela, I.; Pereira, P.; Fernandes, A.; Falcão, A.S.; Cardoso, F.L.; Vaz, A.R.; et al. "Tricellulin expression in brain endothelial and neural cells.". Cell and tissue research 351 3 (2013): 397-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881223461&partnerID=MN8TOARS.
    10.1007/s00441-012-1529-y
  15. Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Early beneficial effects". Neurochemical Research 38 3 (2013): 644-659. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876416140&partnerID=MN8TOARS.
    10.1007/s11064-012-0963-2
  16. Vaz, A.R.; Silva, S.L.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Selective vulnerability of rat brain regions to unconjugated bilirubin". Molecular and Cellular Neuroscience 48 1 (2011): 82-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960929537&partnerID=MN8TOARS.
    10.1016/j.mcn.2011.06.008
  17. Fernandes, A.; Barateiro, A.; Falcão, A.S.; Silva, S.L.-A.; Vaz, A.R.; Brito, M.A.; Marques Silva, R.F.; Brites, D.. "Astrocyte reactivity to unconjugated bilirubin requires TNF-a and IL-1ß receptor signaling pathways". GLIA 59 1 (2011): 14-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349235777&partnerID=MN8TOARS.
    10.1002/glia.21072
  18. Silva, S.L.; Osório, C.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Silva, R.F.M.; Brites, D.. "Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin". Journal of Neurochemistry 117 3 (2011): 412-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954420884&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07200.x
  19. Vaz, A.R.; Silva, S.L.; Barateiro, A.; Fernandes, A.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin". Experimental Neurology 229 2 (2011): 381-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137679&partnerID=MN8TOARS.
    10.1016/j.expneurol.2011.03.004
  20. Brito, M.A.; Vaz, A.R.; Silva, S.L.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "N-methyl-D-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity". Molecular Medicine 16 9-10 (2010): 372-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956632156&partnerID=MN8TOARS.
    10.2119/molmed.2009.00152
  21. Silva, S.L.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation". Neurobiology of Disease 40 3 (2010): 663-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957807564&partnerID=MN8TOARS.
    10.1016/j.nbd.2010.08.010
  22. Brites, D.; Fernandes, A.; Falcão, A.S.; Gordo, A.C.; Silva, R.F.M.; Brito, M.A.. "Biological risks for neurological abnormalities associated with hyperbilirubinemia". Journal of Perinatology 29 (2009): S8-S13. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549101479&partnerID=MN8TOARS.
    10.1038/jp.2008.214
  23. Fernandes, A.; Falcão, A.S.; Abranches, E.; Bekman, E.; Henrique, D.; Lanier, L.M.; Brites, D.. "Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis". Developmental Neurobiology 69 9 (2009): 568-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749127695&partnerID=MN8TOARS.
    10.1002/dneu.20727
  24. Brito, M.A.; Rosa, A.I.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells". Neurobiology of Disease 29 1 (2008): 30-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549090063&partnerID=MN8TOARS.
    10.1016/j.nbd.2007.07.023
  25. Brito, M.A.; Lima, S.; Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid". NeuroToxicology 29 2 (2008): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749156518&partnerID=MN8TOARS.
    10.1016/j.neuro.2007.11.002
  26. Fernandes, A.; Vaz, A.R.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin". Journal of Neuropathology and Experimental Neurology 66 9 (2007): 789-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548454884&partnerID=MN8TOARS.
    10.1097/nen.0b013e3181461c74
  27. Falcão, A.S.; Bellarosa, C.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Tiribelli, C.; Brites, D.. "Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin". Neuroscience 144 3 (2007): 878-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845899686&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2006.10.026
  28. Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes". European Journal of Neuroscience 25 4 (2007): 1058-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847203682&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2007.05340.x
  29. Falcão, A.S.; Silva, R.F.M.; Fernandes, A.; Brito, M.A.; Brites, D.. "Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes". Brain Research 1149 1 (2007): 191-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247503256&partnerID=MN8TOARS.
    10.1016/j.brainres.2007.02.039
  30. Falcão, A.S.; Silva, R.F.M.; Pancadas, S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus". Journal of Neuroscience Research 85 6 (2007): 1229-1239. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248141645&partnerID=MN8TOARS.
    10.1002/jnr.21227
  31. Silva, R.F.M.; Falcão, A.S.; Fernandes, A.; Gordo, A.C.; Brito, M.A.; Brites, D.. "Dissociated primary nerve cell cultures as models for assessment of neurotoxicity". Toxicology Letters 163 1 (2006): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644832098&partnerID=MN8TOARS.
    10.1016/j.toxlet.2005.09.033
  32. Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Gordo, A.C.; Gama, M.J.; Brito, M.A.; Brites, D.. "Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin". Journal of Neurochemistry 96 6 (2006): 1667-1679. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644812051&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.03680.x
  33. Gordo, A.C.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Unconjugated bilirubin activates and damages microglia". Journal of Neuroscience Research 84 1 (2006): 194-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745770001&partnerID=MN8TOARS.
    10.1002/jnr.20857
  34. Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state". Acta Neuropathologica 112 1 (2006): 95-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745401404&partnerID=MN8TOARS.
    10.1007/s00401-006-0078-4
  35. Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells". Neurobiology of Disease 20 2 (2005): 199-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-26944464585&partnerID=MN8TOARS.
    10.1016/j.nbd.2005.03.001
  36. Fernandes, A.; Silva, R.F.M.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS". Journal of Neuroimmunology 153 1-2 (2004): 64-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242679583&partnerID=MN8TOARS.
    10.1016/j.jneuroim.2004.04.007
Preprint
  1. Falcão, Ana S; Lopes-da-Silva, Mafalda; Antas, Pedro; Escrevente, Cristina; Pedro, Margarida; Coelho, Rita; Ferreira, Inês S; et al. "Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration". 2024. https://doi.org/10.1101/2024.09.17.613413.
    10.1101/2024.09.17.613413
Thesis / Dissertation
  1. Falcão AS. "New findings on neuropathological effects of hyperbilirrubinemia in astrocytes and neurons. Evaluation of cell susceptibilities and of neuritic development.". PhD, Universidade de Lisboa Faculdade de Farmácia, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/09/09 NRF2 as a therapeutic target in early and intermediate age-related macular degeneration International Symposium on Age-related Macular Degeneration
(Baden-baden, Germany)
2023/05/12 Testing NRF2 activators that can reduce lipofuscin accumulation in Retinal Pigmented Epithelium cell models NOVA Medical School Casual Fridays
Nova Medical School (Lisbon, Portugal)
2023/04/21 Testing stimulatory NRF2 compounds that can reduce lipofuscin accumulation in Retinal Pigmented Epithelium cell models 3rd BenBedPhar COST Action Meeting
BenBedPhar COST Action Meeting (Zagreb, Croatia)
2021/04/28 TFEB-mediated reduction of autofluorescent granule load in retinal pigment epithelium RPE Cell Biology and Metabolism Virtual Seminar Series
parna Lakkaraju, Department of Ophthalmology University of California, San Francisco (United States)
2015/05/29 Anti-inflammatory regulatory effect of vinyl sufone on microglia activation 29ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Aveiro, Portugal)
2014/01/14 A new look on gliomas Lisbon Area of Neuroscience Meeting
IMM (Lisbon, Portugal)
2013/05/31 The dark side of neural precursor cells: New cues for gliomagenesis XIII Reunião da Sociedade Portuguesa de Neurociências
(Luso, Portugal)
2012/05/09 Neural stem cells: discovery, properties and potential for therapy Jornadas de Ciências Farmacêuticas
Instituto de Ciências de Saúde Egas Moniz Egas Moniz, Monte de Caparica (Portugal)
2008/10/22 Bilirubin-induced neuritic atrophy and cell dysfunction is aggravated and reversed by glycoursodeoxycholic acid XVI Congresso Nacional de Bioquímica
(Ponta Delgada, Portugal)
2008/03/08 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators. Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation Scientific Advisory Board Meeting with iMed.UL, Faculdade de Farmácia da Universidade de Lisboa
(Lisbon, Portugal)
2008/01/28 Neonatal hyperbilirubinemia-uncovering the potential neurodevelopmental” iMed.UL Symposium
(Lisbon, Portugal)
2006/09/25 New findings on neuropathological effects of hyperbilirubinemia in astrocytes and neurons. Evaluation of cell susceptibilities and of neuritic development
Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2003/05/05 Are interleukins new players in the pathophysiology of bilirubin encephalopathy? 2003 Pediatric Academic Societies’ Annual Meeting
(Seattle, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/01 - Current Dissecting the mechanisms underlying the reduction of lipofuscin like autofluorescent granules load in cellular models of age-related macular degeneration
Supervisor
 Bioquimica e Biomedicina (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/01 - 2024/10/31 Testing new NRF2 activators in an Age-related macular degeneration mouse model
Co-supervisor
 Investigação Biomédica (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/09/12 - 2023/12 Development of a screening pipeline to identify modulators of Nrf2 activity
Co-supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/10/01 - 2019/12/19 Curcumin analogs: novel potential therapeutic agents for the treatment of neurodegenerative diseases
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/09/26 - 2018/06/01 Development of a new nanostructured scaffold for neural stem/ progenitor cell transplantation
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/10/01 - 2016/06/30 Evaluation of bilirubin effects during microglia ageing
Co-supervisor
Università degli Studi di Bologna Dipartimento di Farmacia e Biotecnologie, Italy
2014/09/01 - 2015/11/01 Development of alkylating hybrid molecules of triazenes for the treatment of glioma
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/10/01 - 2015/06/30 Exploring gliomas: evaluation of new biomarkers and therapeutic approach with modified Temozolomide
Supervisor
Universidade do Porto, Portugal
2013/09/01 - 2014/06/30 Evaluation of bilirubin effects on the protein expression of activated microglia and modulation by bilirubin-treated neuronal media
Co-supervisor
2012/09/01 - 2013/11/01 Microglia demostrate age-dependent performance and interaction with beta-amyloid peptide
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/09/01 - 2013/11/01 Neural precursors and microvasculature changes in glioma/glioblastoma: new biomarkers?
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/09/01 - 2012/11/01 Establishing the validity of GUDCA as a coadjuvant of temozolomide therapy in gliomas
Co-supervisor
Universidade de Coimbra, Portugal
2011/09/01 - 2012/11 Cues for cancer stem cells origin
Co-supervisor
Universidade Nova de Lisboa, Portugal
2010/10/01 - 2012/10/01 Exploring the pathways of neural stem cell tropism to malignant stem/progenitor cell differentiation as a way to expand treatment strategies to astrocytoma
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/09/01 - 2011/11/01 Chemoattraction and microglia migration determinants
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008/09/01 - 2009/11/01 Effect of unconjugated bilirubin on nerve cells development: role of Mrp1”
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2006/01/01 - 2017/05/01 OUTREACH ACTIVITIES: Organization of the activity “Ciência Viva no laboratório”- Course to high school students regarding “Às voltas com os neurónios e não só”, as well as the“Brain awareness week”, at iMed.ULisboa. (2006/01/01)
Workshop
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/11/07 - 2014/11/08 Organization, teaching and supervision of a postgraduated course “Profiling alterations in microglia dynamic properties by neuroinflammation” (2014/11/07 - 2014/11/08)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/02/06 - 2012/02/10 Organization, teaching and supervision of a postgraduated course “Basic notions and implementation of nerve cell cultures- 2nd edition (2012/02/06 - 2012/02/10)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/12/13 - 2010/12/21 Organization of the scientific meeting “Players in brain deregulation”, Neuron Glia Biology in Health and Disease Unit, iMed.UL (2010/12/13 - 2010/12/21)
Meeting (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/12/15 - 2010/12/17 Colaboration in the organization of the Symposium “Neurosciences” of the XVII Congresso Nacional de Bioquímica, Porto, Portugal, December 15-17. This symposium involved the participation of Professor Doutor Vivaldo Moura Neto, with the lecture entitled “Cross-talk between parenchyma and glial cells: highlights in brain tumors”. (2010/12/15 - 2010/12/17)
Symposium (Member of the Organising Committee)
2010/01/25 - 2010/01/29 Organization, teaching and supervision of a postgraduated course “Basic notions and implementation of nerve cell cultures” (2010/01/25 - 2010/01/29)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/02/19 - 2009/02/21 Organization, teaching and supervision of a postgraduated course “Update on the methodologies involved on inflammation assessment (2009/02/19 - 2009/02/21)
Workshop
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/01/26 - 2009/01/30 Organization, teaching and supervision of a postgraduated course "Inflammation, an experimental approach” (2009/01/26 - 2009/01/30)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/01/21 - 2008/01/25 Organization, teaching and supervision of a postgraduated course entitled "Biomarcadores de Stresse Oxidativo - Interesse e Aplicação (2008/01/21 - 2008/01/25)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2004/02/16 - 2004/02/20 Organization, teaching and supervision of a postgraduate course entitled “Cytokines and acute neurotoxicity” (2004/02/16 - 2004/02/20)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/10/25 Phenotypic characterization of the induced p16-positive cell population in a spinal cord injury context
(Thesis) Main arguer
 Inês Domingos (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/12/13 CYP46A1 at the Crosstalk Between Autophagy and Oxidative Stress in Niemann-Pick Type C Disease
(Thesis) Main arguer
 Sofia Alexandra Gomes Nunes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/11/18 Evaluation of neuron/glia network signals using 2D/3D platforms and ALS experimental models
(Thesis) Main arguer
 Beatriz da Cunha Suyumov (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/02/25 UNVEILLING THE INTERPLAY BETWEEN ACTIVATED ASTROCYTES AND NEURONS IN AN IN VITRO MODEL OF ALZHEIMER’S DISEASE
(Thesis) Main arguer
 Filipa Moreira (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/11/28 The impact of Bridging Integrator 1 (BIN1) rare coding mutations on the development of Late-Onset Alzheimer´s Disease
(Thesis) Main arguer
 Ana Cláudia Marques (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/11/01 Estudo da contribuição das integrinas na motilidade de células de glioblastoma
(Thesis) Main arguer
 Diana Matias (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/11/01 Effect of unconjugated bilirubin on nerve cells development: role of Mrp1
(Thesis) Arguer
 Ema Torrado (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2022/01/01 - Current COST action CA20121- Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar) member of WG1 and WG2
2013/01/01 - Current International Society for Neurochemistry Member
2006/01/01 - Current Portuguese Society of Neurosciences; Member
2015/01/01 - 2017/05/01 COST Action BM1402 - Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) member of WG2

Committee member

Activity description
Role 		Institution / Organization
2023/11/01 - 2024/11/01 Postdoctoral committee at Nova Medical School
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/01/10 - 2019/09/01 PhD Thesis Comittee of Diane Aurore Mendes Pereira, for the development of the project intitled “Tackling Colon Cancer Stem Cells with microRNAs”
Member
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/09/01 - Current Teaching of Practical and laboratorial classes in the subject of "Biologia Celular e Molecular", from the Medicine course of Faculdade de Ciencias Médicas da Universidade Nova de Lisboa Medicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - Current Teaching of Practical and laboratorial classes in the subject of "Tecidos, Células e Moleculas", from the Medicine course of Faculdade de Ciencias Médicas da Universidade Nova de Lisboa Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - Current Teaching of practical classes in the subject "Mecanismos Moleculares de Doença", from the Medicine Course of Faculdade de Ciencias Médicas Universidade Nova de Lisboa Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/01/10 - 2017/07/31 Participation in the teaching of theoretical classes in the core course “Fundamentals of Medicinal Chemistry", from the MedChem Train PhD programme involving the Universities of Coimbra (UCoimbra) and Lisboa (ULisboa), in consortium with Bial, Bluepharma and Hovione (Curso de doutoramento (conclusão de unidades curriculares))
2014/10/01 - 2017/06/01 Teaching of practical and laboratorial classes in the subject “Physiopathology of Neuroinflammation"from the Master in Biopharmaceutical Sciences of the Faculdade de Farmácia, Universidade de Lisboa Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/10/01 - 2017/06/01 Teaching of practical and laboratorial classes in the subject “Brain Barriers in Drug Development”, from the Master in Biopharmaceutical Sciences of the Faculdade de Farmácia, Universidade de Lisboa, Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/10/01 - 2017/06/01 Teaching of the subject “Development and Organization of the Nervous System”, from the Master in Biopharmaceutical Sciences of the Faculdade de Farmácia, Universidade de Lisboa, by presenting a lecture entitled “Neurogenesis” and by teaching practical and laboratorial classes. Development and Organization of the Nervous System (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008/10/01 - 2017/06/01 Teaching of theoretical and pratical classes of "Histology and Embriology", a subject of the Integrated Master in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/06/01 - 2017 Regent of the subject “Neuropathology and Neuropharmacology”, from the Master in Biopharmaceutical Sciences of the Faculdade de Farmácia, Universidade de Lisboa (co-regency with with Professor Alexandra Brito). Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/06/01 - 2012/06/30 Colaboration in the subject “Neurobiology”, from the Master course of Cellular and Molecular Biology from the Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, by the presentation of a lecture in the field of “Nerve cell reactivity to bilirubin and inflammation mediators Biologia Molecular Humana (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2003/10/01 - 2012/06/01 Colaboration in the subject “Neurobiology”, from the Integrated Master in Pharmaceutical Sciences of the Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal, by monitoring the laboratorial classes and by the presentation of lectures in the field of “Neural differentiation and Neurotoxicity Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021/07/01 - Current Frontiers- Neuropharmacology

Mentoring / Tutoring

Topic Student name
2022/02/01 - Current PIATI Program (Program for Integration of Medicine Students in Research Works) Inês Pedroso Nunes
2022/09/01 - 2023/09/01 Effect of repurposed drugs on autofluorescent granule accumulation in a cellular model of age-related macular degeneration Vicente Lopes Miguel
2023/02/01 - 2023/03/31 Effect of repurposed drugs on autofluorescent granule accumulation in a cellular model of age-related macular degeneration Tomás Guerreiro
2019/01/01 - 2021/10/01 Inês Ferreira
2021/01/01 - 2021/03/31 Supervision of Lab Technician Carolina Piedade
2018/01/01 - 2018/12/31 Gabriela Santos

Other jury / evaluation

Activity description Institution / Organization
2024/09/11 - 2024/09/24 Selection Juri member for 2 Research Grants (BI) for the development of R&D activities to be undertaken by Masters registered in a PhD Programme or a non-degree course, with the reference SAI/2024/11, within the scope of the projects LA/P/0087/2020-LS4F at the institution Faculdade de Ciências Médicas | NOVA Medical School (FCM|NMS) of the Universidade NOVA de Lisboa Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/11/01 - 2023/11/01 Selection juri for a Research fellow to integrate the project HR22-00569- “NRF2 as a novel therapeutic target in early and intermediate age-related macular degeneration” (NASCENT) La Caixa Health 2022, |NOVA Medical School, Universidade NOVA de Lisboa Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/08/01 - 2023/08/01 Selection juri for a Research fellow to integrate the project HR22-00569- “NRF2 as a novel therapeutic target in early and intermediate age-related macular degeneration” (NASCENT) La Caixa Health 2022, |NOVA Medical School, Universidade NOVA de Lisboa
2023/07/07 - 2023/07/07 Participation in the evaluation juri of Tomás Guerreiro regarding the Project untitled “Repurposing strategy to treat Age-related macular degeneration with curcumin and dimethyl fumarate, for Biochemistry graduation from Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/06/22 - 2022/06/22 Participation in the evaluation juri of Madalena Diniz Marinho regarding the Project report in Cell and Molecular Biology untitled “Gap junctional protein Cx43 is an essential element to exosome mediated proteostasis on burdened cells", from Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/10/06 - 2021/10/10 Review Board for iMED Conference Innovate Competition 13.0, Nova Medical School, Universidade Nova de Lisboa Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/09/01 - 2016/09/01 Participation in the evaluation juri of Jorge Grilo regarding the lab rotation from the MedChem Train PhD programme involving the Universities of Coimbra (UCoimbra) and Lisboa (ULisboa), in consortium with Bial, Bluepharma and Hovione. Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/07/01 - 2016/07/01 Participation in the evaluation juri of João Paulo Almeida Ribeiro regarding the Project II report intitled “Screening of antitumoral molecules in a mouse glioma cell line”, from the Master graduation in Pharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/07/01 - 2016/07/01 Participation in the evaluation juri of Filipa Gomes regarding the lab rotation from the MedChem Train PhD programme involving the Universities of Coimbra (UCoimbra) and Lisboa (ULisboa), in consortium with Bial, Bluepharma and Hovione. Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2013 Selection juri for a Research fellow to integrate the project entitled “Será a microglia um novo alvo farmacológico com potencial interesse na esclerose lateral amiotrófica (ELA)?” (PTDC/ SAU-FAR/118787/2010), Faculdade de Farmácia, Universidade de Lisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/07/01 - 2011/07/01 Participation in the discussion of the presentation/research project from Sandra Macedo entitled “Establishing the validity of NAC/Dexpramipexole as adjuvants of Temozolamide therapy in gliomas", as part of the subject Projecto II from the Master graduation in Biopharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/10/01 - 2010/10/01 Participation in the discussion of the presentation/report from Ema Torrado entitled “Exploring the pathways of neural stem cell tropism to malignant stem/progenitor cell differentiation as a way to expand treatment strategies to astrocytoma", as part of the “Curso Formação Avançada” from the PhD in Pharmacy, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/10/01 - 2010/10/01 Participation in the discussion of the presentation/review from Sandra Macedo entitled “Chemoresistance in Gliomas: Role of MRP1", as part of the subject Projecto I from the Master graduation in Biopharmaceutical Sciences, Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal. Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2009 Selection for a Pregraduated student to colaborate to the Human Biology sub-group from the Faculdade de Farmácia, Universidade de Lisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2007 Selection juri for a Research fellow to integrate the project entitled “Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation” (PTDC/SAU-NEU/64385/2006), Faculdade de Farmácia, Universidade de Lisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2007 Selection juri of a Research fellow to integrate the project entitled “Study of the blood-brain barrier disruption by neurotoxins and modulation by therapeutic agents in a human model: effects of bilirubin and endotoxin on brain microvascular endothelial cell monolayer integrity and protective role of bile acids” (PTDC/SAU-FCF/68819/2006), Faculdade de Farmácia, Universidade de Lisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinctions

Award

2015 Best Poster t the 7th iMed.ULisboa Postgraduate Students Meeting
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 Travel Award for the attendance of the ISN/ASN International Meeting in Cancun, Mexico
International Society for Neurochemistry, Switzerland
2012 Best poster in Hershey Conference on Developmental Brain injury
Hershey Conference Scientific Comittee , United Kingdom
2010 Travel grant for the participation in the 2010 European Society of Pediatric Research Annual Meeting, Copenhagen
Fundação Calouste Gulbenkian, Portugal
2005 Travel grant for the participation in the 2005 Pediatric Annual Meeting
Pediatric Academic Societies’, United States
2005 Full bursary for participation in the 40th Annual Meeting of EASL
Roche Diagnostics Ltd, United Kingdom
2003 Best Poster in Congresso Nacional de Gastrenterologia e Endoscopia Digestiva
EASL International Liver Foundation, Switzerland
2002 Sociedade Farmacêutica Lusitana Award- Best student in the course of Pharmaceutical Sciences
Ordem dos Farmaceuticos, Portugal
1999 University Scholarship- Best student of the Faculty of Pharmacy, scholar year 1998/1999
Universidade de Lisboa Faculdade de Farmácia, Portugal
1998 University Scholarship- Best student of the Faculty of Pharmacy, scholar year 1997/1998
Universidade de Lisboa Faculdade de Farmácia, Portugal
1997 University Scholarship- Best student of the Faculty of Pharmacy, scholar year 1996/1997
Universidade de Lisboa Faculdade de Farmácia, Portugal