José Alberto Martins. Completed the degree in Biochemistry in 1988 by University of Coimbra, Faculdade de Ciências e Tecnologia and Doctor of Philosophy, PhD in Chemistry, in 2000 by University of Warwick. Published 51 articles in journals. Has 1 section(s) of books. Has 2 patent(s) registered. Supervised 3 PhD thesis and co-supervised 4. Supervised 5 MSc dissertation(s) and co-supervised 3. Participates and/or participated as Co-Principal Investigator (Co-PI) in 1 project(s) and Researcher in 7 project(s). Works in the area(s) of Organic, Bioorganic and Bioinorganic Chemistry and Medicinal Chemistry. In his curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: "metal chelators"; "metal complexes"; "medical imaging"; "MRI, PET, SPECT"; "multimodality"; "Contrast Agents"; "relaxometry"; "nanoparticles"; "nanostructures"; "SPION"; "magnetogels"; "hyperthermia"; "peptide synthesis"; "self-assembly"; "self-assembled peptide hydrogels"; "drug-delivery"; "theranostics" .

Personal identification

Full name
José Alberto Martins

Citation names

  • Martins, José
  • Martins J. A.
  • Martins, J.

Author identifiers

Ciência ID

Email addresses

  • jmartins@quimica.uminho.pt (Professional)


  • 253604385 (Professional)


  • Departamento de Química, Universidade do Minho, Campus de Gualtar , 4710-057, Gualtar, Braga, Braga, Portugal (Professional)


Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Natural sciences - Biological Sciences - Biochemistry


Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Advanced (C1) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Degree Classification
1996/09/01 - 2000/09/03
PhD Chemistry (Doctor of Philosophy)
Major in Organic and Bioorganic Chemistry
University of Warwick, United Kingdom
"Solution and Solid-Phase Biotransformations" (THESIS/DISSERTATION)
1984/09/01 - 1988/07/30
Bioquímica (Licenciatura)
Major in NA
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Teaching in Higher Education

Host institution
2000/06/01 - 2020 Assistant Professor (University Teacher) Universidade do Minho, Portugal
Universidade do Minho Centro de Química, Portugal
1996 - 2000 Assistant (University Teacher) Universidade do Minho, Portugal
Universidade do Minho Departamento de Química, Portugal


Designation Funders
2021/01/02 - 2023/06/30 New imaging biomarkers in the assessment of chronic total coronary occlusion - BioImage2CTO – 39698
BioImage2CTO – 39698
Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Imagem Biomédica e Investigação Translacional, Portugal

Universidade de Coimbra, Portugal

Universidade do Minho Centro de Química, Portugal
Agência Nacional de Inovação SA
2018/09/15 - 2021/09/14 Self-assembled minimalist peptide hydrogels inspired by mussel adhesive proteins for biomedical applications
Co-Principal Investigator (Co-PI)
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2013/06/03 - 2015/09/30 Concise and highly stereoselective strategy in the synthesis of aza-sugars. Theoretical studies and biological evaluation of Products
Universidade do Minho, Portugal

Universidade do Minho Centro de Química, Portugal
Fundação para a Ciência e a Tecnologia
2012/03/01 - 2015/08/31 Influence of Salt Additives on Protein Extraction in Aqueous Polymer/Salt Two-Phase Systems
Universidade do Minho, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal
Fundação para a Ciência e a Tecnologia
2009/01/05 - 2012/07/03 Common strategy for the synthesis of azasugars and modified nucleotides. Biological evaluation.
Universidade do Minho, Portugal

Universidade do Minho Centro de Química, Portugal

Universidade do Algarve, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
2008/01/01 - 2011/12/31 Targeted Nanostructures for Multimodal Molecular Medical Imaging
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Minho, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2005/06/01 - 2008/05/31 The Influence of the Chemical Structure of Polymers on Proteins Partition
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Laboratório de Processos de Separação e Reacção Laboratório de Catálise e Materiais, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
2003/10/01 - 2007 Targeted Contrast Agents for Magnetic Resonance Imaging (MRI) and Nuclear Scintigraphy (TARCAS)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia


Book chapter
  1. Sérgio R.S. Veloso; Paula M. T. Ferreira; Martins J. A.; Paulo J. G. Coutinho; Elisabete M. S. Castanheira. "Advances in Nanotheranostics with Plasmonic and Magnetic Nanoparticles". In Nanoparticles for Brain Drug Delivery, edited by Carla Vitorino; Andreia Jorge; Alberto A.C.C. Pais. United States: . Taylor & Francis CRC Press, 2021.
Journal article
  1. Vilaça, Helena; Carvalho, André; Castro, Tarsila; Castanheira, Elisabete M. S.; Hilliou, Loic; Hamley, Ian; Melle-Franco, Manuel; Ferreira, Paula M. T.; Martins J. A.. Corresponding author: Martins J. A.. "Unveiling the Role of Capping Groups in Naphthalene N-Capped Dehydrodipeptide Hydrogels". Gels 9 6 (2023): 464. http://dx.doi.org/10.3390/gels9060464.
    Open access • 10.3390/gels9060464
  2. Correia da Silva, Daniela; Jervis, Peter J.; Martins J. A.; Valentão, Patrícia; Ferreira, Paula M.T.; Pereira, David M.. Corresponding author: Pereira, David M.. "Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation of endoplasmic reticulum stress". International Immunopharmacology 119 (2023): 110178. http://dx.doi.org/10.1016/j.intimp.2023.110178.
  3. Oliveira, Carlos B. P.; Gomes, Valéria; Ferreira, Paula M. T.; Martins, José A.; Jervis, Peter J.. "Peptide-Based Supramolecular Hydrogels as Drug Delivery Agents: Recent Advances". Gels 8 11 (2022): 706. http://dx.doi.org/10.3390/gels8110706.
  4. Carlos B. P. Oliveira; Renato B. Pereira; David M. Pereira; Loic Hilliou; Tarsila G. Castro; José A. Martins; Peter J. Jervis; Paula M. T. Ferreira. "Aryl-Capped Lysine-Dehydroamino Acid Dipeptide Supergelators as Potential Drug Release Systems". International Journal of Molecular Sciences 23 19 (2022): 11811. https://doi.org/10.3390/ijms231911811.
    Open access • Published • 10.3390/ijms231911811
  5. Oliveira, Carlos B. P.; Veloso, Sérgio R. S.; Castanheira, Elisabete M. S.; Figueiredo, Pedro R.; Carvalho, Alexandra T. P.; Hilliou, Loic; Pereira, Renato B.; et al. "An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low critical gelation concentration—prepared from a known folate receptor ligand". Soft Matter 18 20 (2022): 3955-3966. http://dx.doi.org/10.1039/d2sm00121g.
  6. Nuno R. da Silva; Paula Jorge; José A. Martins; José A. Teixeira; João C. Marcos. "Initial Screening of Poly(ethylene glycol) Amino Ligands for Affinity Purification of Plasmid DNA in Aqueous Two-Phase Systems". Life 11 11 (2021): 1138. https://doi.org/10.3390/life11111138.
  7. Zoltán Garda; Tamara Kócs; István Bányai; José A. Martins; Ferenc Krisztián Kálmán; Imre Tóth; Carlos F. G. C. Geraldes; Gyula Tircsó. "Complexes of Bifunctional DO3A-N-(a-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies". Molecules 26 16 (2021): 4956. https://doi.org/10.3390/molecules26164956.
  8. Carolina Amorim; Sérgio R. S. Veloso; Elisabete M. S. Castanheira; Loic Hilliou; Renato B. Pereira; David M. Pereira; José A. Martins; Peter J. Jervis; Paula M. T. Ferreira. "Bolaamphiphilic Bis-Dehydropeptide Hydrogels as Potential Drug Release Systems". Gels 7 2 (2021): 52. https://doi.org/10.3390/gels7020052.
  9. Jervis, Peter J.; Hilliou, Loic; Pereira, Renato B.; Pereira, David M.; Martins, José A.; Ferreira, Paula M. T.. "Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supramolecular Hydrogel". Nanomaterials 11 3 (2021): 704. http://dx.doi.org/10.3390/nano11030704.
  10. Peter J. Jervis; Carolina Amorim; Teresa Pereira; José A. Martins; Paula M. T. Ferreira. "Dehydropeptide Supramolecular Hydrogels and Nanostructures as Potential Peptidomimetic Biomedical Materials". International Journal of Molecular Sciences 22 5 (2021): 2528. https://doi.org/10.3390/ijms22052528.
  11. Veloso, Sérgio R.S.; Jervis, Peter J.; Silva, Joana F.G.; Hilliou, Loic; Moura, C.; Pereira, David M.; Coutinho, Paulo J.G.; et al. "Supramolecular ultra-short carboxybenzyl-protected dehydropeptide-based hydrogels for drug delivery". Materials Science and Engineering: C 122 (2021): 111869. http://dx.doi.org/10.1016/j.msec.2021.111869.
  12. Sérgio R. S. Veloso; Joana F. G. Silva; Loic Hilliou; Cacilda Moura; Paulo J. G. Coutinho; José A. Martins; Martín Testa-Anta; et al. "Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release". Nanomaterials 11 1 (2020): 16. https://doi.org/10.3390/nano11010016.
  13. Sérgio R. S. Veloso; Raquel G. D. Andrade; Beatriz C. Ribeiro; André V. F. Fernandes; A. Rita O. Rodrigues; J. A. Martins; Paula M. T. Ferreira; Paulo J. G. Coutinho; Elisabete M. S. Castanheira. "Magnetoliposomes Incorporated in Peptide-Based Hydrogels: Towards Development of Magnetolipogels". Nanomaterials 10 9 (2020): 1702. https://doi.org/10.3390/nano10091702.
    Published • 10.3390/nano10091702
  14. Moreira, Rute; Jervis, Peter J.; Carvalho, André; Ferreira, Paula M. T.; Martins, José A.; Valentão, Patrícia; Andrade, Paula B.; et al. "Biological Evaluation of Naproxen–Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors". Pharmaceutics 12 2 (2020): 122. http://dx.doi.org/10.3390/pharmaceutics12020122.
    Open access • Published • 10.3390/pharmaceutics12020122
  15. Sérgio R. S. Veloso; J. A. Martins; Loic Hilliou; C. O. Amorim; V. S. Amaral; B. G. Almeida; Peter J. Jervis; et al. "Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy". Journal of Materials Chemistry B 8 (2020): 45-64. https://doi.org/10.1039/C9TB01900F.
    Published • 10.1039/C9TB01900F
  16. Jervis, Peter J.; Amorim, Carolina; Pereira, Teresa; Martins, José A.; Ferreira, Paula M. T.. "Exploring the properties and potential biomedical applications of NSAID-capped peptide hydrogels". Soft Matter 16 44 (2020): 10001-10012. http://dx.doi.org/10.1039/d0sm01198c.
  17. André Carvalho; Juan Gallo; David Pereira; Patrícia Valentão; Paula Andrade; Loic Hilliou; Paula Ferreira; Manuel Bañobre-López; José Martins. "Magnetic Dehydrodipeptide-Based Self-Assembled Hydrogels for Theragnostic Applications". Nanomaterials 9 4 (2019): 541. https://doi.org/10.3390/nano9040541.
    Published • 10.3390/nano9040541
  18. Sérgio R. S. Veloso; Carlos A. B. Magalhães; Ana Rita O. Rodrigues; H. Vilaça; Maria-João R. P. Queiroz; J. A. Martins; Paulo J. G. Coutinho; Paula M. T. Ferreira; Elisabete M. S. Castanheira. "Novel dehydropeptide-based magnetogels containing manganese ferrite nanoparticles as antitumor drug nanocarriers". Physical Chemistry Chemical Physics 21 (2019): 10377. https://doi.org/10.1039/C9CP00352E.
    Published • 10.1039/C9CP00352E
  19. Veloso, Sérgio; Ferreira, Paula; Martins, José; Coutinho, Paulo; Castanheira, E. M. S.. "Magnetogels: Prospects and Main Challenges in Biomedical Applications". Pharmaceutics 10 3 (2018): 145. http://dx.doi.org/10.3390/pharmaceutics10030145.
    Published • 10.3390/pharmaceutics10030145
  20. Helena Vilaça; Tarsila Castro; Fernando M. G. Costa; Manuel Melle-Franco; Loic Hilliou; Ian W. Hamley; Elisabete M. S. Castanheira; José A. Martins; Paula M. T. Ferreira. "Self-assembled RGD dehydropeptide hydrogels for drug delivery applications". Journal of Materials Chemistry B 5 43 (2017): 8607-8617. https://doi.org/10.1039/C7TB01883E.
  21. Mao, B. Y.; Calatayud, D. G.; Mirabello, V.; Kuganathan, N.; Ge, H. B.; Jacobs, R. M. J.; Shepherd, A. M.; et al. "Fluorescence-Lifetime Imaging and Super-Resolution Microscopies Shed Light on the Directed- and Self-Assembly of Functional Porphyrins onto Carbon Nanotubes and Flat Surfaces". Chemistry-a European Journal 23 41 (2017): 9772-9789. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000405923800014&KeyUID=WOS:000405923800014.
    Published • 10.1002/chem.201605232
  22. Marslin, Gregory; Sarmento, Bruno; Franklin, Gregory; Martins, José; Silva, Carlos; Gomes, Andreia; Sárria, Marisa; et al. "Curcumin Encapsulated into Methoxy Poly(Ethylene Glycol) Poly(e-Caprolactone) Nanoparticles Increases Cellular Uptake and Neuroprotective Effect in Glioma Cells". Planta Medica 83 05 (2016): 434-444. http://dx.doi.org/10.1055/s-0042-112030.
    Published • 10.1055/s-0042-112030
  23. Mao, Boyang; Calatayud, David G.; Mirabello, Vincenzo; Hodges, Benjamin J.; Ribeiro Martins, Jose Alberto; Botchway, Stanley W.; Mitchels, John M.; Pascu, Sofia I.. "Interactions between an Aryl Thioacetate-Functionalized Zn(II) Porphyrin and Graphene Oxide". Advanced Functional Materials 26 5 (2016): 687-697. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000369969100004&KeyUID=WOS:000369969100004.
    Published • 10.1002/adfm.201504147
  24. Vilaca, Helena; Hortelao, Ana C. L.; Castanheira, Elisabete M. S.; Queiroz, Maria-Joao R. P.; Hilliou, Loic; Hamley, Ian W.; Martins, Jose A.; Ferreira, Paula M. T.. "Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers". Biomacromolecules 16 11 (2015): 3562-3573. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000364614300016&KeyUID=WOS:000364614300016.
    Published • 10.1021/acs.biomac.5b01006
  25. Martins, José; Vilaca, H.; Pereira, G.; Castro, T. G.; Hermenegildo, B. F.; Shi, J.; Faria, T. Q.; et al. "New self-assembled supramolecular hydrogels based on dehydropeptides". Journal of Materials Chemistry B 3 30 (2015): 6355-6367. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358351400023&KeyUID=WOS:000358351400023.
    Published • 10.1039/C5TB00501A
  26. Goncalves, C.; Silva, J. P.; Antunes, I. F.; Ferreira, M. F. M.; Martins, J. A.; Geraldes, C. F. G. C.; Lalatonne, Y.; et al. "Dextrin-Based Nanomagnetogel: In Vivo Biodistribution and Stability". Bioconjugate Chemistry 26 4 (2015): 699-706. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000353177300011&KeyUID=WOS:000353177300011.
    Published • 10.1021/acs.bioconjchem.5b00024
  27. Ferreira, Miguel F.; Goncalves, Janaina; Mousavi, Bibimaryam; Prata, Maria I. M.; Rodrigues, Sergio P. J.; Calle, Daniel; Lopez-Larrubia, Pilar; et al. "Gold nanoparticles functionalised with fast water exchanging Gd3+ chelates: linker effects on the relaxivity". Dalton Transactions 44 9 (2014): 4016-4031. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349993400017&KeyUID=WOS:000349993400017.
    Published • 10.1039/c4dt03210a
  28. Ferreira, Miguel F.; Pereira, Goretti; Andre, Joao P.; Prata, M. I. M.; Ferreira, Paula M. T.; Martins, Jose A.; Geraldes, Carlos F. G. C.. "Ga[NO2A-N-(alpha-amino)propionate] chelates: synthesis and evaluation as potential tracers for Ga-68 PET". Dalton Transactions 43 21 (2014): 8037-8047. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335926800043&KeyUID=WOS:000335926800043.
    Published • 10.1039/c4dt00386a
  29. Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; et al. "Ln[DO3A-N-alpha-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties". Dalton Transactions 43 8 (2013): 3162-3173. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000330785100019&KeyUID=WOS:000330785100019.
    Published • 10.1039/c3dt52958d
  30. Gonçalves, C.; Lalatonne, Y.; Melro, L.; Badino, G.; Ferreira, M.F.M.; David, L.; Geraldes, C.F.G.C.; et al. "New dextrin nanomagnetogels as contrast agents for magnetic resonance imaging". Journal of Materials Chemistry B 1 42 (2013): 5853-5864. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885464908&partnerID=MN8TOARS.
    Published • 10.1039/c3tb21063d
  31. Barros, S.C.; Louro, R.O.; Micaêlo, N.M.; Martins, J.A.; Marcos, J.C.; Cavaco-Paulo, A.. "NMR and molecular modelling studies on elastase inhibitor-peptides for wound management". Reactive and Functional Polymers 73 10 (2013): 1357-1365. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885376832&partnerID=MN8TOARS.
    Published • 10.1016/j.reactfunctpolym.2013.02.011
  32. Ferreira, M.F.; Martins, A.F.; Martins, C.I.O.; Ferreira, P.M.; Tóth, E.; Rodrigues, T.B.; Calle, D.; et al. "Amide conjugates of the DO3A-N-(a-amino)propionate ligand: Leads for stable, high relaxivity contrast agents for MRI?". Contrast Media and Molecular Imaging 8 1 (2013): 40-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868094442&partnerID=MN8TOARS.
    Published • 10.1002/cmmi.1492
  33. Barros, Sandra Cerqueira; Martins, José Alberto; Marcos, João Carlos; Cavaco-Paulo, Artur; Barros, S.C.; Martins, J.A.; Marcos, J.C.; Cavaco-Paulo, A.. "Influence of secretory leukocyte protease inhibitor-based peptides on elastase activity and their incorporation in hyaluronic acid hydrogels for chronic wound therapy". Biopolymers 98 6 (2012): 576-590. http://dx.doi.org/10.1002/bip.22166.
    Published • 10.1002/bip.22166
  34. Pereira, G.; Ferreira, M.F.; Castanheira, E.M.S.; Martins, J.A.; Ferreira, P.M.T.. "Synthesis of 2,6-bis(oxazolyl)pyridine ligands for luminescent Ln III complexes". European Journal of Organic Chemistry 21 (2012): 3905-3910. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863952052&partnerID=MN8TOARS.
    Published • 10.1002/ejoc.201200177
  35. Ferreira, M.F.; Mousavi, B.; Ferreira, P.M.; Martins, C.I.O.; Helm, L.; Martins, J.A.; Geraldes, C.F.G.C.. "Gold nanoparticles functionalised with stable, fast water exchanging Gd 3+ chelates as high relaxivity contrast agents for MRI". Dalton Transactions 41 18 (2012): 5472-5475. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859796835&partnerID=MN8TOARS.
    Published • 10.1039/c2dt30388d
  36. Barros, S.C.; Martins, J.A.; Marcos, J.C.; Cavaco-Paulo, A.. "Characterization of potential elastase inhibitor-peptides regulated by a molecular switch for wound dressings applications". Enzyme and Microbial Technology 50 2 (2012): 107-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855432805&partnerID=MN8TOARS.
    Published • 10.1016/j.enzmictec.2011.10.006
  37. Silvério, S.C.; Ferreira, L.A.; Martins, J.A.; Marcos, J.C.; Macedo, E.A.; Teixeira, J.A.. "Lysozyme and bovine serum albumin partitioning in polyethylene glycol-phenylalanine conjugate polymer/salt aqueous two-phase systems". Fluid Phase Equilibria 322-323 (2012): 19-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859959117&partnerID=MN8TOARS.
    Published • 10.1016/j.fluid.2012.03.003
  38. Alves, M.J.; Costa, F.T.; Duarte, V.C.M.; Fortes, A.G.; Martins, J.A.; Micaelo, N.M.. "Advances in the synthesis of homochiral (-)-1-azafagomine and (+)-5-epi-1-azafagomine. 1-N-phenyl carboxamide derivatives of both enantiomers of 1-azafagomine: Leads for the synthesis of active a-glycosidase inhibitors.". Journal of Organic Chemistry 76 23 (2011): 9584-9592. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255170789&partnerID=MN8TOARS.
    Published • 10.1021/jo201486q
  39. Teixeira, J.M.C.; Dias, D.M.; Cañada, F.J.; Martins, J.A.; Andrá, J.P.; Jimánez-Barbero, J.; Geraldes, C.F.G.C.. "The interaction of La 3+ complexes of DOTA/DTPA glycoconjugates with the RCA 120 lectin: A saturation transfer difference NMR spectroscopic study". Journal of Biological Inorganic Chemistry 16 5 (2011): 725-734. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051552449&partnerID=MN8TOARS.
    Published • 10.1007/s00775-011-0773-z
  40. Gonçalves, C.; Ferreira, M.F.M.; Santos, A.C.; Prata, M.I.M.; Geraldes, C.F.G.C.; Martins, J.A.; Gama, F.M.. "Studies on the biodistribution of dextrin nanoparticles". Nanotechnology 21 29 (2010): 295103. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954412360&partnerID=MN8TOARS.
    Published • 10.1088/0957-4484/21/29/295103
  41. Torres, S.; Martins, J.A.; André, J.P.; Neves, M.; Santos, A.C.; Prata, M.I.M.; Geraldes, C.F.G.C.. "Radiolabeled 153Sm-chelates of glycoconjugates: Multivalence and topology effects on the targeting of the asialoglycoprotein receptor". Radiochimica Acta 95 6 (2009): 343-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250738372&partnerID=MN8TOARS.
  42. Ferreira, M.F.; Martins, A.F.; Martins, J.A.; Ferreira, P.M.; Tóth, E.; Geraldes, C.F.G.C.. "Gd(DO3A-N-a-aminopropionate): A versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents". Chemical Communications 42 (2009): 6475-6477. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350289656&partnerID=MN8TOARS.
    Published • 10.1039/b912201j
  43. Silvério, S.; Torres, S.; Martins, A.F.; Martins, J.A.; André, J.P.; Helm, L.; Prata, M.I.M.; Santos, A.C.; Geraldes, C.F.G.C.. "Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging". Dalton Transactions 24 (2009): 4656-4670. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749103643&partnerID=MN8TOARS.
    Published • 10.1039/b823402g
  44. Torres, S.; Prata, M.I.M.; Santos, A.C.; André, J.P.; Martins, J.A.; Helm, L.; Tóth, É.; et al. "Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: In vitro characterization and in vivo animal imaging studies". NMR in Biomedicine 21 4 (2008): 322-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649111266&partnerID=MN8TOARS.
    Published • 10.1002/nbm.1194
  45. Torres, S.; Martins, J.A.; André, J.P.; Pereira, G.A.; Kiraly, R.; Brücher, E.; Helm, L.; Tóth, É.; Geraldes, C.F.G.C.. "H5EPTPACH2OH: Synthesis, relaxometric characterization and 1H NMR spectroscopic studies on the solution dynamics of its LnIII complexes". European Journal of Inorganic Chemistry 2007 35 (2007): 5489-5499. http://www.scopus.com/inward/record.url?eid=2-s2.0-37349104891&partnerID=MN8TOARS.
  46. Gonçalves, C.; Martins, J.A.; Gama, F.M.. "Self-assembled nanoparticles of dextrin substituted with hexadecanethiol". Biomacromolecules 8 2 (2007): 392-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847254019&partnerID=MN8TOARS.
    Published • 10.1021/bm060993e
  47. Prata, M.I.; Santos, A.C.; Torres, S.; André, J.P.; Martins, J.A.; Neves, M.; García-Martín, M.L.; et al. "Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies.". Contrast media & molecular imaging 1 6 (2006): 246-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947723488&partnerID=MN8TOARS.
    Published • 10.1002/cmmi.111
  48. Torres, S.; Martins, J.A.; André, J.P.; Geraldes, C.F.G.C.; Merbach, A.E.; Tóth, É.. "Supramolecular assembly of an amphiphilic GdIII chelate: Tuning the reorientational correlation time and the water exchange rate". Chemistry - A European Journal 12 3 (2006): 940-948. http://www.scopus.com/inward/record.url?eid=2-s2.0-30744441893&partnerID=MN8TOARS.
    Published • 10.1002/chem.200500551
  49. Baía, P.; André, J.P.; Geraldes, C.F.G.C.; Martins, J.A.; Merbach, A.E.; Tóth, É.. "Lanthanide(III) chelates of DTPA bis(amide) glycoconjugates: Potential imaging agents targeted at the asyaloglycoprotein receptor". European Journal of Inorganic Chemistry 2005 11 (2005): 2110-2119. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444493273&partnerID=MN8TOARS.
    Published • 10.1002/ejic.200400766
  50. André, J.P.; Geraldes, C.F.G.C.; Martins, J.A.; Merbach, A.E.; Prata, M.I.M.; Santos, A.C.; De Lima, J.J.P.; Tóth, É.. "Lanthanide(III) complexes of DOTA-glycoconjugates: A potential new class of lectin-mediated medical imaging agents". Chemistry - A European Journal 10 22 (2004): 5804-5816. http://www.scopus.com/inward/record.url?eid=2-s2.0-9244230554&partnerID=MN8TOARS.
  51. Martins, J. A. R.; Crout, D. H. G.; Critchley, P.; Martins, J.A.R.; Crout, D.H.G.. "C-n microspheres as surrogate membranes in glycosidase-catalysed hydrolysis of glycolipids". Chemical Communications 10 2 (2003): 198-199. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000188617000033&KeyUID=WOS:000188617000033.
  52. Chevolot, Y.; Martins, J.; Milosevic, N.; Leonard, D.; Zeng, S.; Malissard, M.; Berger, E. G.; et al. "Immobilisation on polystyrene of diazirine derivatives of mono- and disaccharides: Biological activities of modified surfaces". Bioorganic & Medicinal Chemistry 9 11 (2001): 2943-2953. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000171753000022&KeyUID=WOS:000171753000022.
    Published • 10.1016/s0968-0896(01)00172-9
  53. Leand´onard, D.; Chevolot, Y.; Heger, F.; Martins, J.; Crout, D.H.G.; Sigrist, H.; Mathieu, H.J.. "ToF-SIMS and XPS study of photoactivatable reagents designed for surface glycoengineering: Part III. 5-Carboxamidopentyl-n-[m-[3-(trifluoromethyl)diazirin-3-yl]phenyl-ß- D -galactopyranosyl]-(1->4)-1-thio-ß-D-glucopyranoside (lactose aryl diazirine) on diamond". Surface and Interface Analysis 31 6 (2001): 457-464. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035365231&partnerID=MN8TOARS.
    Published • 10.1002/sia.1071

Intellectual property

  2. Sigrist, H.; Chevolot, Y.; Crout, D.H.G; Martins, José; Mthieu, H-J; Lohmann, D.. 2004. "Preparation of carbohydrate structures on material surfaces, useful to manufacture biomedical devices, comprises photochemical fixation of benzene derivatives and enzymatic attachment of further carbohydrates to radicals of modified surface , US6780980-B1 Patent".


Thesis Title
Degree Subject (Type)
Institution / Organization
2022/01/01 - 2026/12/31 Self-assembled peptide-based photothermal hydrogels: cancer theranostic combining thermo-chemotherapy and MRI imaging (2021.07290.BD)
Doutoramento em Química Aplicada (PhD)
Universidade do Minho Centro de Química, Portugal
2020/09/01 - 2024 Innovative peptide-based self-assembled theranostic hydrogel platform for combined MRI imaging and magnetic hyperthermia-activated cancer thermo-chemotherapy (2020.07743.BD)
Programa Doutoral em Química (PhD)
Universidade do Minho Centro de Química, Portugal
2018/03/15 - 2023 Dextrin: a platform for the development of drug delivery systems
Doctoral Program in Biological Engineering (PhD)
Universidade do Minho Centro de Engenharia Biológica, Portugal

Universidade do Minho Centro de Química, Portugal
2019/09/01 - 2021/02/17 Towards injectable theranostic platforms: magnetic peptide-based supramolecular hydrogels with drug-delivery, MRI reporting and hyperthermia capabilities.
Mestrado em Química Medicinal (Master)
Universidade do Minho Centro de Química, Portugal
2019 - 2019 Preparation and characterisation of magnetic dehydropeptide-based hydrogels.
Química Medicinal (Master)
Universidade do Minho, Portugal
2016 - 2016 Synthesis of novel pyridine bis-oxazole ligands for preparation of luminescent Ln(III) metal complexes.
Química Medicinal (Master)
Universidade do Minho, Portugal
2011 - 2015 Synthesis of new peptide derivatives that self-assemble into nanostructured hydrogels for biomedical applications
phD Chemistry (PhD)
Universidade do Minho Centro de Química, Portugal
2010 - 2014 Multifunctional gold nanoparticles for magnetic resonance imaging (MRI) and therapeutic applications.
PhD (PhD)
Universidade do Minho Centro de Química, Portugal
2013 - 2013 Synthesis, characterization, energy transfer and binding properties of quantum dots and its superstructures
Química Medicinal (Master)
Universidade do Minho, Portugal
2011/09/01 - 2012/12/01 Gold nanoparticles and quantum dots functionalised with Gd3+ chelates as Contrast Agentes for medical imaging
Mestrado em Química medicinal
Universidade do Minho Centro de Química, Portugal
2011/09/01 - 2012/11/01 Self-assembled non-covalent hydrogels based on dehydrodipeptides
Mestrado em Química Medicinal (Master)
Universidade do Minho Centro de Química, Portugal
2011 - 2011 Synthesis of new peptide derivates that self-assemble into nanostructured hydrogels for biomedical applications
Ciências (PhD)
Universidade do Minho, Portugal
2010 - 2010 Optimized molecular imaging agents: from metal chelates to micelles to gold nanoparticles
Ciências (PhD)
Universidade do Minho, Portugal
2007 - 2010 Gadolinium Complexes for Magnetic Resonance Imaging: Synthesis, Characterization and Evaluation of the Pharmacoki-netic Behaviour
Ciências (PhD)
Universidade do Minho, Portugal
2008/09/01 - 2009/12/02 Nanomagnetogels for biomedical apllications
Mestardo em Micro e Nanotecnologias (Master)
Universidade do Minho Centro de Engenharia Biológica, Portugal
2008/09/01 - 2009/12/02 Paramagnetic gold nanoparticles for magnetic resonance imaging and therapeutic applications
Mestrado em Química medicinal (Master)
Universidade do Minho Centro de Química, Portugal
2003/09/01 - 2004/01/01 Metal complexes of glycoconjugates for medical applications
Mestrado em Química (Master)
Universidade do Minho Centro de Química, Portugal

Mentoring / Tutoring

Topic Student name
2010 - 2013 Magnetonanogels: new formulations for drug delivery Catarina Gonçalves