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Joana Caldeira graduated in Microbiology at the Biotechnology College of the Portuguese Catholic University and in 2011/12/09 got her PhD in Biomedicine (Faculty of Medicine of the University of Porto). She has a total of 35 publications (23 research papers, 3 book chapters and 9 journal proceedings) with over 1000 citations and an h index=15 (Scopus April, 2025), and 2 provisional patent applications. Joana has been interested in understanding the role of the extracellular matrix at the cancer/regeneration interface and in exploring the way it can be manipulated to recapitulate initial developmental stages, improving current regenerative therapies, namely of intervertebral disc disease. She has secured funding as Principal Investigator from 7 national and international agencies including EUROSPINE, ON Foundation, AO Foundation, the Portuguese Foundation for Science and Technology and the European Commission, and has been a team member of 8 other projects. Joana has been distinguished with several awards, namely the L'Oréal Portugal Medal of Honor for Women in Science 2018, the EIT Jumpstarter, the Amyris BIG Impact Award and Women TechEU. Her research has been highlighted by several national news agencies. She is currently supervising 1 PhD thesis and co-supervising 1 MSc student. Joana has also co-supervised 1 PhD thesis, 1 FEBS short-term fellowship, 3 graduate thesis, 2 Erasmus+ internships and 8 Master thesis (2 as co-supervisor and 1 from the Erasmus Programme), as well as 2 research assistants and 3 internships. She has also presented her work in over 50 national and international meetings (with posters and oral communication either submitted or by invitation) and participated in several science communication initiatives either as a mentor, project coordinator or collaborator. Currently, Joana is also the chair of the i3S Fundraising Team, as well as CEO and co-founder of FetalDisc, Lda.
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Identification

Personal identification

Full name
Joana Caldeira Fernandes Frey Ramos

Citation names

  • Caldeira, Joana

Author identifiers

Ciência ID
EB12-B28E-CD73
ORCID iD
0000-0003-3327-3702
Researcher Id
J-6016-2013
Scopus Author Id
26535557000

Email addresses

  • joana.caldeira@ineb.up.pt (Professional)
  • joana.caldeira@i3s.up.pt (Professional)

Addresses

  • INEB. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2020
Concluded
 Building and Leading Research Teams (Outros)
Universidade do Porto Faculdade de Psicologia e de Ciências da Educação, Portugal
2017 - 2017
Concluded
 Module 1 - Writing a Call to Action (Outros)
Call to Action, Portugal
2017 - 2017
Concluded
 Module 2 - Establishing successful partnerships with companies (Outros)
Call to Action, Portugal
2011/12/09
Concluded
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"FACTORS THAT CONTRIBUTE TO THE MALIGNANT TRANSFORMATION OF E-CADHERIN MUTANT CELLS IN HDGC: A STUDY IN DROSOPHILA, CELL CULTURE AND TUMOURS " (THESIS/DISSERTATION)
 Aprovada por unanimidade, com distinção
2011 - 2011
Concluded
 Scientific entertainment (Outros)
Science4You, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
2005
Concluded
 Microbiologia (Licenciatura)
Universidade Catolica Portuguesa Escola Superior de Biotecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 16
Affiliation

Others

Category
Host institution 		Employer
2023 - Current Associate Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/12 - Current Co-founder FETALDISC, LDA (FETALIX), Portugal
2017 - Current Coordinator of the i3S Fundraising team Instituto Nacional de Engenharia Biomedica, Portugal
Instituto Nacional de Engenharia Biomedica, Portugal
(...)
2019/11/01 - 2023 Junior Researcher Instituto Nacional de Engenharia Biomedica, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/07 - 2019/09 Visiting Researcher at Imperial College London Instituto Nacional de Engenharia Biomedica, Portugal
Imperial College London Department of Bioengineering, United Kingdom
2012/01/01 - 2018/10/31 Postdoctoral fellow Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Engenharia Biomedica, Portugal
(...)
2012 - 2018 INEB PhD Vice-representative Instituto Nacional de Engenharia Biomedica, Portugal
Instituto Nacional de Engenharia Biomedica, Portugal
2016 - 2017 Scientific collaborator Yscience, Portugal
2009/01/01 - 2011/08/15 PhD Student Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2007/01/01 - 2008/12/31 PhD Student Fundação para a Ciência e a Tecnologia, Portugal
Centro Andaluz de Biologia del Desarrollo, Spain
2005/09/15 - 2006/12/31 Research Assistant Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Centro Andaluz de Biologia del Desarrollo, Spain
2004/09/15 - 2005/07/10 Undergraduate student internship Hospital de Sao Joao, Portugal
Projects

Grant

Designation Funders
2023 - 2024 FETALIX - Rejuvenating the spine to set you free
101113806
Principal investigator
Horizon 2020

Contract

Designation Funders
2025 - Current Spine Reborn: a fetal tailored recipe for intervertebral disc regeneration (REBORN_DISC)
15864
Principal investigator
2023/09/30 - 2024/11/30 Stop & Rewind: CRISPR-mediated fetal gene activation for IVD regeneration (REWIND)
AOS-Startup-23-022
Principal investigator
AO Foundation
Ongoing
2022/07 - 2024/07 Fetal-inspired IVD regeneration through CRISPR-mediated MSC editing (FEedIT)
EXPL/BTM-ORG/0880/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
2021 - 2023 Rewinding the clock: CRISPR-mediated NP cell editing for IVD rejuvenation (CLOCKit)
20-165
Principal investigator
ON Foundation

EUROSPINE The Spine Society of Europe
Ongoing
2021 - 2023 Fetal-inspired hierarchical biomaterials for regeneration in a harsh microenvironment: the nucleus of the intervertebral disc (FETBIO)
PTDC/BTM-MAT/0438/2020
Junior Researcher - core cv
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2020/12 Repurposing CRISPR for disc regeneration
TFR Grant 2018_15
Principal investigator
Instituto Nacional de Engenharia Biomedica, Portugal
 EUROSPINE The Spine Society of Europe
Concluded
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/01 - 2018/12 Sensing dysfunctional E-cadherin cells in gastric epithelia (SENSE)
Provided by PTCRIS: 138871
FCT - PTDC//BIM-ONC/0281/2014
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2016 Stem Cells Paracrine Action on Disc Degeneration
EUROSPINE TRF_2015
Post-doc Fellow
Instituto Nacional de Engenharia Biomedica, Portugal
 EUROSPINE The Spine Society of Europe
Concluded
2013/06 - 2015/05 Mutant E-Cadherin and Novel Interactors in Cancer (MECANIC). The role of mutant E-cadherin-integrin-ECM crosstalk in gastric cancer.
Provided by PTCRIS: 124283
124283
PTDC/BIM-ONC/0171/2012
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/04 - 2014/09 Tumour spectrum in Hereditary Diffuse Gastric Cancer
110294
Provided by PTCRIS: 110294
Tumour spectrum in Hereditary Diffuse Gastric Cancer
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/06 - 2013/11 The role of Protein Quality Control in the regulation of E-cadherin and its relevance in cancer.
104017
Provided by PTCRIS: 104017
The role of Protein Quality Control in the regulation of E-cadherin and its relevance in cancer
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/07/01 - 2011/02/28 Single-molecule analysis of cadherin-mediated cell-cell adhesion
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/1R21CA137891-01A1/US
PhD Student Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 National Institutes of Health
Concluded

Other

Designation Funders
2019/10/15 - 2020/07/15 CRISPR-mediated gene activation: the key for in vivo disc regeneration (CRISPR4DISC)
LOREAL_BIM_01_2019
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Santos, S. G.; Gonçalves, R. M.; Caldeira, J.; Barbosa, M. A.; Oliveira, M. J.. "CHAPTER 10. Immunomodulatory Function of Extracellular Vesicles in Cancer and Tissue Repair/Regeneration". In Biomaterials Science Series, 246-270. Royal Society of Chemistry, 2021.
    10.1039/9781839164552-00246
  2. Caldeira, J.; Sousa, A.; Sousa, D.M.; Barros, D.. "Extracellular matrix constitution and function for tissue regeneration and repair". In Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair, 29-72. Elsevier, 2018.
    10.1016/b978-0-08-100803-4.00002-4
  3. Cunha, Carla; Barbosa, Mário; Silva, Andreia; Caldeira, Joana. "Microenvironment-inspired materials for Tissue Regeneration". In Biomimetic Approaches for Tissue Healing. OMICS Publishing Group, 2015.
Conference poster
  1. Ângela Marques-Magalhães; Ana Patrícia Cardoso; Roelands, Jessica; Susana Mendonça ; Osorio, Hugo; Caldeira, Joana; Pedro A. Canão; et al. "Deciphering the ECM-mediated modulation of CCL18 expression by macrophages in colon cancer". Paper presented in XLIX Annual Meeting of the Portuguese Society for Immunology, 2024.
  2. Morena Fiordalisi; Joana Rita Ferreira; Marta Pinto; Cláudia Ribeiro-Machado; Marta Teixeira Pinto; Maria José Oliveira; Mário Barbosa; Raquel Gonçalves* ; Caldeira, Joana. "DONOR AGE MATTERS: INTERVERTEBRAL DISC DECELLULARIZATION FOR TISSUE REGENERATION". Paper presented in EORS 2023, 2023.
  3. Morena Fiordalisi; Inês Sousa; Mário Barbosa; Raquel Gonçalves*; Caldeira, Joana. "MIMICKING EARLY DEVELOPMENTAL STAGES FOR INTERVERTERBAL DISC REPAIR". Paper presented in ETRS & SPCE-TC 2023 Joint Annual Meeting, 2023.
  4. Caldeira, Joana; Morena Fiordalisi; Catarina Milheiro; Inês Sousa; Joana Ferreira; Marta Pinto; Cláudia Ribeiro-Machado; et al. "FETAL-INSPIRED SCAFFOLDS FOR INTERVERTEBRAL DISC REGENERATION". Paper presented in ORS PSRS 6th International Spine Research Symposium, 2022.
  5. Catarina Milheiro; Raquel Gonçalves; Mário Barbosa; Caldeira, Joana. "ENGINEERING A CELL-DERIVED EXTRACELLULAR MATRIX FOR INTERVERTEBRAL DISC REGENERATION USING CRISPR/DCAS9". Paper presented in ESB, 2022.
  6. Inês Sousa; Morena Fiordalisi; Mário Barbosa; Raquel Gonçalves; Caldeira, Joana. "OPTIMIZATION OF SCALE-UP CONDITIONS FOR IVD DECELLULARIZATION AND HYDROGEL FORMATION". Paper presented in IJUP, 2022.
  7. Catarina Milheiro; Filipa Freire; Mário Barbosa; Raquel Gonçalves; Caldeira, Joana. "RECAPITULATING THE FETAL INTERVERTEBRAL DISC MICROENVIRONMENT THROUGH EXTRACELULAR MATRIX ENGINEERING USING CRISPR.". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  8. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Unveil the biochemical and biomechanical properties of colorectal cancer patients-derived tissues from different colon locations". Paper presented in The Structural Microenvironment: Breaking down the walls of cancer (EACR), 2022.
  9. Catarina Milheiro; Filipa Freire; Mário Barbosa; Raquel Gonçalves; Caldeira, Joana. "RECAPITULATION OF THE FETAL INTERVERTEBRAL DISC MICROENVIRONMENT THROUGH CRISPR/DCAS9 EDITING". Paper presented in 4th PhDay: Break Borders, Build Opportunities, 2021.
  10. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Dissecting the biochemical and biomechanical properties of colorectal cancer extracellular matrix". Paper presented in II ASPIC-ASEICA International meeting ¿ Current trends in precision medicine in cancer, 2021.
  11. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Dissecting the properties of colorectal cancer patients-derived extracellular matrix". Paper presented in Goodbye Flat Biology: Next generation cancer models, 2021.
  12. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Corresponding author: Maria José Oliveira. "Cancro colorrectal: propriedades bioquímicas e biomecânicas da matriz extracelular de pacientes". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2021.
  13. Ribeiro-Machado, Cláudia; Valdoleiros Silva, Rodrigo; Caldeira, Joana; Mário A. Barbosa; Cristina C. Ribeiro. "Profiling Cell Response to a novel bilayer biomaterial for Periodontal Tissue Regeneration: a proteomic approach". Paper presented in 11th World Biomaterial Congress, 2020.
  14. Telmo Vieira; Fiordalisi, M.F.; Reis, Celso; Magalhães, Ana *; Caldeira, Joana * (equal contribution). "MOLECULARLY ASSEMBLED MATRICES AS PLATFORMS FOR STUDYING CANCER CELLS". Paper presented in iMed Conference 12.0, 2020.
  15. Fiordalisi, M.F.; Joana Rita Ferreira; Ana João Silva; Cláudia Ribeiro-Machado; Barbosa, Mário; Gonçalves, Raquel; Caldeira, Joana. "FETAL EXTRACELLULAR MATRIX-BASED SCAFFOLDS FOR INTERVERTEBRAL DISC REGENERATION". Paper presented in VII BiotechHealth Annual Symposium: 'From bench to bedside: Found in translation', 2020.
  16. Catarina Milheiro; Filipa Freire; Mário Barbosa; Caldeira, Joana. "FETAL GENE ACTIVATION FOR INTERVERTEBRAL DISC REGENERATION". Paper presented in Cell Symposia: Gene- and Cell-Based Therapies: CRISPR, Stem Cells, and Beyond, 2020.
  17. Morena Fiordalisi; Ana João Silva; Marta Pinto; Joana Rita Ferreira; Cláudia Machado; Mário Barbosa; Joana Caldeira * (equal contribution); Raquel Gonçalves *. "FETAL EXTRACELLULAR MATRIX OF NUCLEUS PULPOSUS AS A NATURAL SCAFFOLD FOR INTERVERTEBRAL DISC REJUVENATION". Paper presented in 7th International Congress on Biotechnologies for Spinal Surgery (BioSpine7), 2019.
  18. Morena Fiordalisi; Ana João Silva; Marta Pinto; Joana Rita Ferreira; Cláudia Machado; Mário Barbosa; Joana Caldeira * (equal contribution); Raquel Gonçalves *. "FETAL EXTRACELLULAR MATRIX OF NUCLEUS PULPOSUS AS A NATURAL SCAFFOLD FOR INTERVERTEBRAL DISC REJUVENATION". Paper presented in FEBS Advanced Lecture Course - Matrix Pathobiology, Signaling and Molecular Targets, 2019.
  19. Morena Fiordalisi; Ana João Silva; Marta Pinto; Joana Rita Ferreira; Cláudia Machado; Mário Barbosa; Joana Caldeira * (equal contribution); Raquel Gonçalves *. "FETAL EXTRACELLULAR MATRIX OF NUCLEUS PULPOSUS AS A NATURAL SCAFFOLD FOR INTERVERTEBRAL DISC REJUVENATION". Paper presented in 7th Advanced Summer School: “Do organoids fill the in vivo / in vitro gap?", 2019.
  20. Morena Fiordalisi; Ana João Silva; Marta Pinto; Joana Rita Ferreira; Cláudia Machado; Mário Barbosa; Joana Caldeira * (equal contribution); Raquel Gonçalves *. "FETAL EXTRACELLULAR MATRIX OF NUCLEUS PULPOSUS AS A NATURAL SCAFFOLD FOR INTERVERTEBRAL DISC REJUVENATION". Paper presented in 2nd PhDay at i3S PhD countdown: a time for Science, 2019.
  21. Morena Fiordalisi; Ana João Silva; Marta Pinto; Joana Rita Ferreira; Cláudia Machado; Mário Barbosa; Joana Caldeira * (equal contribution); Raquel Gonçalves *. "FETAL NP DECELLULARIZED SCAFFOLDS: A NOVEL APPROACH FOR IVD REGENERATION". Paper presented in 8th i3S Annual Meeting, 2019.
  22. Morena Fiordalisi; Ana João Silva; Marta Pinto; Cláudia Machado; Raquel Gonçalves; Mário Barbosa; Caldeira, Joana. "OPTIMIZATION OF DECELLULARIZATION OF BOVINE NUCLEUS PULPOSUS FROM DIFFERENT AGES". Paper presented in 1st PhDay at i3S: From bench to stage, from desk to forum, 2018.
  23. Morena Fiordalisi; Ana João Silva; Marta Pinto; Cláudia Machado; Raquel Gonçalves; Mário Barbosa; Caldeira, Joana. "OPTIMIZATION OF DECELLULARIZATION OF BOVINE NUCLEUS PULPOSUS FROM DIFFERENT AGES". Paper presented in Chem2Nature Summer School: "Multifunctional biomedical devices", 2018.
  24. Caldeira, Joana; Morena Fiordalisi; Ana João Silva; Cátia Santa; Hugo Osório; Maria Molinos; Bruno Manadas; Raquel Gonçalves. "NUCLEUS PULPOSUS AGE-ASSOCIATED MATRISOME PROFILES UNRAVEL THE IDEAL PRO-REGENERATIVE MICROENVIRONMENT". Paper presented in 18th European Cells and Materials Meeting 2018 “Cartilage & Disc: Repair and Regeneration”, 2018.
  25. Morena Fiordalisi; Ana João Silva; Marta Pinto; Cláudia Machado; Mário Barbosa; Caldeira, Joana; Raquel Gonçalves. "FETAL EXTRACELLULAR MATRIX AS A NATURAL SCAFFOLD FOR INTERVERTEBRAL DISC REJUVENATION". Paper presented in 7th i3S Annual Meeting, 2018.
  26. Caldeira, Joana; Cátia Santa; Hugo Osório; Maria Molinos; Bruno Manadas; Raquel Gonçalves; Mário Barbosa. "NUCLEUS PULPOSUS AGE ASSOCIATED SCAFFOLD PROFILING". Paper presented in 6th China-Europe Symposium on Biomaterials on Regenerative Medicine, 2017.
  27. Caldeira, Joana; Cátia Santa; Hugo Osório; Maria Molinos; Bruno Manadas; Raquel Gonçalves; Mário Barbosa. "PATHOBIOLOGY OF THE AGEING MATRIX: ON THE PATH TO INTERVERTEBRAL DISC REGENERATION". Paper presented in 6th FEBS Advanced Lecture Course - Matrix Pathobiology, Signaling and Molecular Targets, 2017.
  28. Caldeira, Joana; Cátia Santa; Hugo Osório; Maria Molinos; Bruno Manadas; Raquel Gonçalves; Mário Barbosa. "UNDERSTANDING MATRISOMAL CUES TO RECREATE A PRO-REGENERATIVE INTERVERTEBRAL DISC MICROENVIRONMENT". Paper presented in TERMIS European Chapter Meeting 2017, 2017.
  29. Caldeira, Joana; Cátia Santa; Hugo Osório; Bruno Manadas; Maria Molinos; Raquel Seruca; Mário Barbosa. "MATRISOME CHANGES DURING INTERVERTEBRAL DISC DEVELOPMENT AND AGEING". Paper presented in EMBO Young Scientists’ Forum (EYSF) 2016, 2016.
  30. Caldeira, Joana; Cátia Santa; Hugo Osório; Maria Molinos; Bruno Manadas; Raquel Gonçalves; Mário Barbosa. "EXTRACELLULAR MATRIX PROFILING DURING INTERVERTEBRAL DISC DEVELOPMENT AND AGEING". Paper presented in 5th i3S Annual Meeting, 2016.
  31. Caldeira, Joana; Maria Molinos; Hugo Osório; Cátia Santa; Bruno Manadas; Raquel Seruca; Mário Barbosa. "UNRAVELING MATRIX AGEING CUES - ON THE PATH TO INTERVERTEBRAL DISC REGENERATION". Paper presented in Gordon Research Conference, 'Tissue Repair & Regeneration-Exploring Innovations in Tissue Repair and Regeneration: From Bench to Therapies', 2015.
  32. Caldeira, Joana; Hugo Osório; Maria Molinos; Cátia Santa; Bruno Manadas; Raquel Seruca. "BOVINE NP ECM – WHAT CHANGES AS TIME GOES BY?". Paper presented in 1st Matrix Biology Winter Conference, 2014.
  33. Caldeira, Joana; Hugo Osório; Maria Molinos; Cátia Santa; Bruno Manadas; Raquel Seruca. "BOVINE NP ECM – WHAT CHANGES AS TIME GOES BY?". Paper presented in I3S 4th Annual Meeting IBMC | INEB | IPATIMUP, 2014.
  34. Caldeira, Joana; Hugo Osório; Maria Molinos; Cátia Santa; Bruno Manadas; Raquel Seruca; Mário Barbosa. "BOVINE NP ECM – WHAT CHANGES AS TIME GOES BY?". Paper presented in Winter Science Club 2014, 2014.
  35. Caldeira, Joana; Hugo Osório; Maria Molinos; Marta Santos; Raquel Seruca; Mário Barbosa. "EXTRACELLULAR MATRIX MEDIATED THERAPY: A NOVEL PATH TO INTERVERTEBRAL DISC REGENERATION?". Paper presented in 3rd I3S Scientific Retreat IBMC | INEB | IPATIMUP together in Science, 2012.
  36. Caldeira, Joana; Hugo Osório; Maria Molinos; Marta Santos; Raquel Seruca; Mário Barbosa. "EXTRACELLULAR MATRIX MEDIATED THERAPY: A NOVEL PATH TO INTERVERTEBRAL DISC REGENERATION?". Paper presented in Interrogations at the Biointerface Advanced Summer School: The Self-Renewal/Differentiation Interface, 2012.
  37. Caldeira, Joana; Hugo Osório; Maria Molinos; Marta Santos; Raquel Seruca; Mário Barbosa. "AGE COMPARATIVE ANALYSIS OF NUCEUS PULPOSUS EXTRACELLULAR MATRIX PROTEOMIC PROFILE". Paper presented in Winter Science Club 2012, 2012.
  38. Marta Teixeira Pinto; Paula Soares; Hugo Prazeres; Hugo Pinheiro; Caldeira, Joana; Raquel Seruca; Carla Oliveira. "THE NEW CHICK IN TOWN". Paper presented in 2nd I3S Scientific Retreat IBMC | INEB | IPATIMUP together in Science, 2011.
  39. Joana Simões Correia; Caldeira, Joana; Joana Figueiredo; Rui Lopes; Luis Serrano; Fernando Casares; Raquel Seruca. "A TRANSLATIONAL APPROACH TO UNDERSTAND THE POST-TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF E-CADHERIN". Paper presented in I3S Scientific Retreat 2010, 2010.
  40. Caldeira, Joana; Joana Correia; Joana Figueiredo; Francisca Vasconcelos; Carla Oliveira; Gianpaolo Suriano; Raquel Seruca; Fernando Casares. "NEW E-CADHERIN INTERACTORS: A DROSOPHILA MODEL TO STUDY CDH1 GERMLINE MISSENSE MUTATIONS". Paper presented in Gordon Research Conference: Cell Contact & Adhesion – Cell-Cell Junction Functions, Polarity and Morphogenesis, 2009.
  41. Caldeira, Joana; Joana Correia; Joana Figueiredo; Francisca Vasconcelos; Carla Oliveira; Gianpaolo Suriano; Raquel Seruca; Fernando Casares. "A DROSOPHILA MODEL TO STUDY GASTRIC CANCER ASSOCIATED GERMLINE MISSENSE MUTATIONS". Paper presented in Barcelona Biomed Conferences - Modelling Cancer in Drosophila 09, 2009.
  42. Marie Laure Dichtel-Danjoy; Caldeira, Joana; Fernando Casares. "SOXF IS A NOVEL TUMOR SUPPRESSOR IN THE WNT SIGNALLING PATHWAY". Paper presented in Development and Cancer – CNIO Cancer Conferences, 2008.
  43. Cristina Piñeiro-López; Caldeira, Joana; Fernando Casares. "FUNCTIONAL CHARACTERIZATION OF FEZ (FOREBRAIN EMBRYONIC ZINC-FINGER) IN DROSOPHILA MELANOGASTER". Paper presented in Joint Meeting of the British & Spanish Developmental Biology Societies, 2008.
  44. Caldeira, Joana; Fernando Casares. "QUALITATIVE AND QUANTITATIVE EXPRESSION OF CADHERINS – THE ANSWER TO TISSUE MORPHOGENESIS?". Paper presented in Mechanisms of Early development – Cell Fate, Determination, Morphogenesis and Patterning, 2007.
  45. Caldeira, Joana; Rui Amorim; Isabel Azevedo; Maria João Martins. "MODULATION OF ALKALINE PHOSPHATASE ACTIVITY FROM SACCHAROMYCES CEREVISIAE GROWN IN HIGH OR LOW PHOSPHATE MEDIUM". Paper presented in Experimental Biology 2006, 2006.
  46. Caldeira, Joana; Paulo pereira; Alexandra Teixeira; Sofia Pinho; Paulo Ferreira; Carla Oliveira; Raquel Seruca; Gianpaolo Suriano; Fernando Casares. "IDENTIFICATION OF SIGNALING PATHWAYS AFFECTED BY E-CADHERIN MISSENSE MUTATIONS ASSOCIATED WITH HEREDITARY DIFFUSE GASTRIC CANCER (HDGC) – A DROSOPHILA MODEL". Paper presented in EMBO/IGB Workshop - Cell Migration, Tissue Invasion and Disease, 2006.
Journal article
  1. Joana Ferreira; Maria Leonor Moura; Sofia Pilão; Ana Luísa Castro; Morena Fiordalisi; Catarina Leite Pereira; Caldeira, Joana; Raquel Gonçalves. "Decoding Intervertebral Disc Cell Populations: Challenges in Isolation and Phenotype Definition". Tissue Engineering Part B (2025):
    Under revision
  2. Catarina Milheiro; Maria Leonor Moura; Mario Amendola; Mario Barbosa; Caldeira, Joana. "Harnessing CRISPR potential for Intervertebral Disc Regeneration Strategies". Frontiers in Bioengineering and Biotechnology (2025):
    Accepted
  3. Ferreira, J. R.; Caldeira, J.; Sousa, M.; Barbosa, M. A.; Lamghari, M.; Almeida-Porada, G.; Gonçalves, R. M.. "Dynamics of CD44+ bovine nucleus pulposus cells with inflammation". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-59504-7.
    10.1038/s41598-024-59504-7
  4. Ribeiro-Machado, Cláudia; Santos, Susana G.; Amaral, Inês A.; Caldeira, Joana; Pereira, Paulo; Barbosa, Mário A.; Cunha, Carla. "Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept". npj Regenerative Medicine 8 1 (2023): http://dx.doi.org/10.1038/s41536-023-00309-z.
    10.1038/s41536-023-00309-z
  5. Molinos, Maria; Fiordalisi, Morena F.; Caldeira, Joana; Almeida, Catarina R.; Barbosa, Mário A.; Gonçalves, Raquel M.. "Alterations of bovine nucleus pulposus cells with aging". Aging Cell 22 8 (2023): http://dx.doi.org/10.1111/acel.13873.
    10.1111/acel.13873
  6. Joana Caldeira; Morena Francesca Fiordalisi; Joana Rita Ferreira; Marta Laranjeiro Pinto; Cláudia Ribeiro-Machado; Marta Teixeira Pinto; Maria José Oliveira; Mário Adolfo Barbosa; Raquel Madeira Gonçalves. "The impact of matrix age on intervertebral disc regeneration". Biomaterials Advances 143 (2022): 213192-213192. http://dx.doi.org/10.1016/j.bioadv.2022.213192.
    10.1016/j.bioadv.2022.213192
  7. Joana Caldeira; Adam Celiz; Nicolas Newell. "A biomechanical testing method to assess tissue adhesives for annulus closure". Journal of the Mechanical Behavior of Biomedical Materials 129 (2022): 105150-105150. https://doi.org/10.1016/j.jmbbm.2022.105150.
    10.1016/j.jmbbm.2022.105150
  8. Fiordalisi, M.F.; Silva, Ana João; Gonçalves, Raquel; Barbosa, Mário; Caldeira, Joana. "Intervertebral disc decellularization: progress and challenges". European Cells and Materials (2021):
    Published • 10.22203/eCM.v042a15
  9. Ferreira, JR; Teixeira, GQ; Neto, e; Ribeiro-Machado, c; Silva, AM; Caldeira, J; Leite Pereira, C; et al. "IL-1ß-pre-conditioned mesenchymal stem/stromal cells’ secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc". European Cells and Materials 41 (2021): 431-543. http://dx.doi.org/10.22203/ecm.v041a28.
    10.22203/ecm.v041a28
  10. Fiordalisi, Morena; Silva, Ana João; Barbosa, Mário; Gonçalves, Raquel; Caldeira, Joana. "Decellularized Scaffolds for Intervertebral Disc Regeneration". Trends in Biotechnology 38 9 (2020): 947-951. http://dx.doi.org/10.1016/j.tibtech.2020.05.002.
    10.1016/j.tibtech.2020.05.002
  11. Caldeira, Joana; Fiordalisi, Morena; Pereira, Carla; Silva, Ana João; Pinto, Marta; Gonçalves, Raquel; Barbosa, Mário. "Fetal-inspired strategies for intervertebral disc regeneration". European Cells and Materials (2019): https://www.ecmconferences.org/abstracts/2019/Collection3/collection3.pdf.
  12. Antunes, J.C.; Pereira, C.L.; Teixeira, G.Q.; Silva, R.V.; Caldeira, J.; Grad, S.; Gonçalves, R.M.; Barbosa, M.A.. "Poly(¿-glutamic acid) and poly(¿-glutamic acid)-based nanocomplexes enhance type II collagen production in intervertebral disc". Journal of Materials Science: Materials in Medicine 28 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-84996606963&partnerID=MN8TOARS.
    10.1007/s10856-016-5787-1
  13. Caldeira, J.; Santa, C.; Osório, H.; Molinos, M.; Manadas, B.; Goncalves, R.; Barbosa, M.. "Matrisome Profiling during Intervertebral Disc Development and Ageing". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85029508543&partnerID=MN8TOARS.
    10.1038/s41598-017-11960-0
  14. Caldeira, Joana; Molinos, Maria; Osório, Hugo; Santa, Cátia; Manadas, Bruno; Gonçalves, Raquel; Seruca, Raquel; Barbosa, Mário. "Decoding matrisome changes during development and ageing: on the path to IVD regeneration". European Cells and Materials 32 Suppl 4 (2016): 47-47. https://www.ecmconferences.org/abstracts/2016/Collection5/pdf/collection5.pdf.
  15. Pereira, C.L.; Teixeira, G.Q.; Ribeiro-Machado, C.; Caldeira, J.; Costa, M.; Figueiredo, F.; Fernandes, R.; et al. "Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988672665&partnerID=MN8TOARS.
    10.1038/srep33836
  16. Silva, A.C.; Rodrigues, S.C. *; Caldeira, J. * (equal contribution); Nunes, A.M.; Sampaio-Pinto, V.; Resende, T.P.; Oliveira, M.J.; et al. "Three-dimensional scaffolds of fetal decellularized hearts exhibit enhanced potential to support cardiac cells in comparison to the adult". Biomaterials 104 (2016): 52-64. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978822623&partnerID=MN8TOARS.
    10.1016/j.biomaterials.2016.06.062
  17. Caldeira, J.; Figueiredo, J.; Brás-Pereira, C.; Carneiro, P.; Moreira, A.M.; Pinto, M.T.; Relvas, J.B.; et al. "E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade". Human Molecular Genetics 24 20 (2015): 5891-5900. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943762566&partnerID=MN8TOARS.
    10.1093/hmg/ddv312
  18. Molinos, M.; Almeida, C.R.; Caldeira, J.; Cunha, C.; Gonçalves, R.M.; Barbosa, M.A.. "Inflammation in intervertebral disc degeneration and regeneration". Journal of the Royal Society Interface 12 104 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84923260818&partnerID=MN8TOARS.
    10.1098/rsif.2014.1191
  19. Caldeira, J.; Molinos, M.; Osório, H.; Santa, C.; Manadas, B.; Almeida, C. R.; Gonçalves, R. M.; Barbosa, M. A.. "On the Path to Autologous IVD Regeneration?". Global Spine Journal 4 1_suppl (2014): s-0034. http://dx.doi.org/10.1055/s-0034-1376657.
    10.1055/s-0034-1376657
  20. Simões-correia, J.; Silva, D.I.; Melo, S.; Figueiredo, J.; Caldeira, J.; Pinto, M.T.; Girão, H.; Pereira, P.; Seruca, R.. "DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo". Human Molecular Genetics 23 8 (2014): 2094-2105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897831766&partnerID=MN8TOARS.
    10.1093/hmg/ddt602
  21. Paredes, J.; Figueiredo, J.; Albergaria, A.; Oliveira, P.; Carvalho, J.; Ribeiro, A.S.; Caldeira, J.; et al. "Epithelial E- and P-cadherins: Role and clinical significance in cancer". Biochimica et Biophysica Acta - Reviews on Cancer 1826 2 (2012): 297-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861800037&partnerID=MN8TOARS.
    10.1016/j.bbcan.2012.05.002
  22. Caldeira, J.; Simões-Correia, J.; Paredes, J.; Pinto, M.T.; Sousa, S.; Corso, G.; Marrelli, D.; et al. "CPEB1, a novel gene silenced in gastric cancer: A Drosophila approach". Gut 61 8 (2012): 1115-1123. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863719147&partnerID=MN8TOARS.
    10.1136/gutjnl-2011-300427
  23. Carneiro, P.; Fernandes, M.S.; Figueiredo, J.; Caldeira, J.; Carvalho, J.; Pinheiro, H.; Leite, M.; et al. "E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions". FEBS Letters 586 18 (2012): 2981-2989. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864922992&partnerID=MN8TOARS.
    10.1016/j.febslet.2012.07.045
  24. Simoes-Correia, J.; Melo, S.; Figueiredo, J.; Caldeira, J.; Pereira, P.; Seruca, R.. "DNAJB4 Differentially Regulates WT and Mutant E-cadherin in Cancer". European Journal of Cancer 48 (2012): S78-S78. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000313036500294&KeyUID=WOS:000313036500294.
    10.1016/S0959-8049(12)71011-0
  25. Figueiredo J; Simões-Correia J; Fernandes J; Mateus AR; Suriano G; Paredes J; Oliveira C; Seruca R. "E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive model.". BMC Proceedings (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254989/.
    10.1387/ijdb.072277jc
  26. Dichtel-Danjoy, M.-L.; Caldeira, J.; Casares, F.. "SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc". Development 136 5 (2009): 761-769. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549091070&partnerID=MN8TOARS.
  27. Caldeira, Joana; Pereira, Paulo S.; Suriano, Gianpaolo; Casares, Fernando. "Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer". International Journal of Developmental Biology 53 8-10 (2009): 1557-1561. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000274515300041&KeyUID=WOS:000274515300041.
  28. J Fernandes; R Amorim; I Azevedo; M.J Martins. "In vitro modulation of alkaline phosphatase activity of Saccharomyces cerevisiae grown in low or high phosphate medium". Brazilian Journal of Medical and Biological Research (2008): https://publons.com/publon/13357343/.
    10.1590/S0100-879X2006005000198
  29. Caldeira, J; Amorim, R; Azevedo, I; Martins, MJ. "Modulation of alkaline phosphatases from Saccharomyces cerevisiae". Faseb Journal (2006): A51-A51. https://www.fasebj.org/doi/abs/10.1096/fasebj.20.4.A51-c.
    10.1093/hmg/ddl093
  30. Pereira, P.S.; Teixeira, A.; Pinho, S.; Ferreira, P.; Fernandes, J.; Oliveira, C.; Seruca, R.; Suriano, G.; Casares, F.. "E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia". Human Molecular Genetics 15 10 (2006): 1704-1712. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745184835&partnerID=MN8TOARS.
    10.1242/dev.032854
  31. Caldeira, J; Amorim, R; Azevedo, I; Martins, MJ. "Modulation of alkaline phosphatases from Saccharomyces cerevisiae". Faseb Journal 20 4 (2006): A51-A51. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000236206500247&KeyUID=WOS:000236206500247.
    10.1096/FASEBJ.20.4.A51-C
Thesis / Dissertation
  1. Caldeira, Joana. "Factors that contribute to the malignant transformation of E-cadherin mutant cells in HDGC: a study in Drosophila, cell culture and tumours". PhD, Universidade do Porto Faculdade de Medicina, 2011.

Intellectual property

Provisional application for patent
  1. 2024. "Extracellular matrix for treatment of intravertebral disc degeneration".
    Disclosed
  2. 2019. "Fetal decellularized nucleus pulposus material and methods for obtaining pharmaceutic compositions to be used in the treatment of intervertebral disc degeneration and back pain".
    Disclosed

Other

Other output
  1. EMBO Workshop on Cell Migration, Tissue Invasion and Disease. BSCB Newsletter. 2007. Caldeira, Joana.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10 A FETAL-BASED INJECTABLE BIOMATERIAL TO TREAT INTERVERTEBRAL DISC DEGENERATION EORS 2023
(Porto, Portugal)
2023/09 FROM TRANSFECTION TO CRISPR/CAS9: A NEW ERA IN MOLECULAR BIOLOGY X Cell Culture and Tissue Training Course: Beyond the microscope, culturing life
(Coimbra, Portugal)
2023/07 MANIPULAÇÃO GENÉTICA E CO-CULTURAS Cultura de Células Animais: da Biologia celular à Bioengenharia
(Porto, Portugal)
2023/05 COMO PODERÃO OS AVANÇOS NOS CONHECIMENTOS DE GENÉTICA HUMANA E DE INTELIGÊNCIA ARTIFICIAL MUDAR A REALIDADE TAL COMO A CONHECEMOS? Tec2Med Summit 4th Edition 2023
(Lisboa, Portugal)
2023/05 FETAL-INSPIRED SCAFFOLDS FOR INTERVERTEBRAL DISC REGENERATION 12th Symposium on Biologic Scaffolds for Regenerative Medicine
(Napa, United States)
2023/01 FETALIX MOBILIsE Launch Event: Molecular Bioengineering - Challenges in Industrial and Clinical Translation
(Porto, Portugal)
2022/10/29 BASIC RESEARCH – EXTRACELLULAR MATRIX-BASED REGENERATIVE THERAPIES FOR THE INTERVERTEBRAL DISC Doctoral Programme in Clinical Neurosciences
(Porto, Portugal)
2022/10 ESTRATEGIAS DE BIOINGENIERÍA PARA REGENERAR EL DISCO INTERVERTEBRAL BASADAS EN EL MICROAMBIENTE FETAL XV XORNADA CIENTÍFICA: Terapia Celular e Medicina Rexenerativa
(Coruña, Spain)
2022/07 AMYRIS INNOVATION BIG IMPACT AWARD 2021 EDITION WINNER TESTIMONY AMYRIS INNOVATION BIG IMPACT AWARD 2021 EDITION WINNER TESTIMONY
(Porto, Portugal)
2022/07 FROM TRANSFECTION TO CRISPR/CAS9: A NEW ERA IN MOLECULAR BIOLOGY IX Cell Culture and Tissue Training Course: Beyond the microscope, culturing life
(Coimbra, Portugal)
2022/04 A FETAL-INSPIRED BIOMATERIAL FOR INTERVERTEBRAL DISC REGENERATION Oporto Biomedical Summit 2nd edition
(Porto, Portugal)
2022/03 CRISPR-MEDIATED FETAL GENE ACTIVATION: A GAME-CHANGER FOR INTERVERTEBRAL DISC REGENERATION XIII Symposium on Bioengineering
(Porto, Portugal)
2021/12/01 HOW TO MOVE TO THE NEXT LEVEL? A BETTER UNDERSTANDING OF COMMERCIALIZATION AND TECHNOLOGY TRANSFER IN THE START-UP WORLD Emerging Europe
2021/07/16 From transfection to CRISPR/Cas9: a new era in molecular biology VIII Cell Culture and Tissue Training Course: Beyond the microscope, culturing life
(Coimbra)
2021/06/01 ENTREPRENEURSHIP FOR BEGINNERS: FROM IDEA TO BUSINESS 4ª edição das Jornadas de Engenharia Biomédica
ISEP (Porto, Portugal)
2021/04/05 EIT TESTIMONIALS & Q&A Pre Jumpstarter Online Workshop
INESC-TEC (Porto, Portugal)
2020 DEGENERATIVE DISC DISEASE: BIOLOGICAL TREATMENT APPROACHES IX Congresso da Sociedade Portuguesa da Patologia da Coluna Vertebral: “Desafios no Tratamento da Patologia da Coluna: no Indivíduo e na Comunidade
2020 RECAPITULATING THE FETAL MICROENVIRONMENT FOR INTERVERTEBRAL DISC REGENERATION Seminar series of the Escola Superior da Saúde on Clincal and Public Health
Escola Superior da Saúde
2019/07 From transfection to CRISPR/Cas9: a new era in molecular biology VII Cell Culture and Tissue Training Course: Beyond the microscope, culturing life – Coimbra Health School (ESTeSC)
(Coimbra, Portugal)
2019/05 Fetal-inspired strategies for intervertebral disc regeneration TERMIS EU 2019 - Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation
(Rhodes, Greece)
2019 CRISPR TECHNOLOGY: THERAPEUTIC APPLICATIONS Post graduating course on Advances on Molecular Oncobiology Applied to Diagnostics and Therapeutics – – Lisboa, 14th December, 2019
Escola Superior de Tecnologia da Saúde de Lisboa (Lisbon, Portugal)
2019 CRISPR TECHNOLOGY: THERAPEUTIC APPLICATIONS Post graduating course on Advances on Molecular Oncobiology Applied to Diagnostics and Therapeutics
ESTeSL (Lisboa, Liberia)
2018/09 Repurposing CRISPR for disc regeneration Action Talks “O papel da Tecnologia na Humanização dos Cuidados de Saúde”
(Lisboa, Portugal)
2018/06 Fetal-inspired biomaterials for intervertebral disc regeneration 1st Meeting of the Portuguese Association for Biofabrication
(Porto, Portugal)
2018/04 Age matters: fetal-inspired biomaterials for intervertebral disc regeneration 9th International Workshop on Interfaces: New Frontiers on Biomaterials
(Santiago de Compostela, Spain)
2017/06 Nucleus Pulposus age-associated matrix profiling 6th Advanced Summer School - Interrogations at the Biointerface
(Porto, Portugal)
2017/05 Pathobiology of the ageing matrix: on the path to intervertebral disc regeneration 6th FEBS Advanced Lecture Course - Matrix Pathobiology, Signaling and Molecular Targets
(Spetses, Greece)
2016/09 Matrisome changes during intervertebral disc development and ageing EMBL-Wellcome Trust Conference: Proteomics in Cell Biology and Disease Mechanisms
(Heidelberg, Germany)
2015/12 Unravelling matrix ageing cues to recover homeostsis . 6th BSRT PhD Symposium – Revealing Prometheus Secrets’: Current Technologies for tissue and organ regeneration
(Berlim, Germany)
2014/04 The intervertebral disc - How do they degenerate? How can we help them in regenerating? AEICBAS Biomedical congress - Bioengineering Workshop (In the skin of a bioengineer)
(Porto, Portugal)
2011/05 CPEB1, a novel gene with anti-angiogenic potential, is silenced in gastric cancer 2nd I3S Scientific Retreat IBMC | INEB | IPATIMUP together in Science
(Póvoa do Varzim, Portugal)
2011/03 Novel genes in gastric cancer: from flies to humans 14th Portugaliae Genetica – Model Organisms: humans et al
(Porto, Portugal)
2010/04 Drosophila as an in vivo model to study cancer GABBA Doctoral Programme – Oncobiology module, 2010 (Cell Invasion)
(Porto, Portugal)
2010/01 Drosophila as an in vivo model to study cancer Gulbenkian Doctoral Programme for Physicians – Oncobiology module, 2010 (Cell Invasion)
(Porto, Portugal)
2009/12 Flying into gastric cancer: novel E-cadherin interactors Portuguese Drosophila Meeting 2009 – IBMC
(Porto, Portugal)
2008/09 E-cadherin interactors in a gastric cancer context - a study in Drosophila EmBO YIP PhD Course 2008 – EMBL
(Heidelberg, Germany)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Evaluation of the regenerative potential of customized fetal matrices in a skin model
Co-supervisor
2021/01/01 - Current CRISPR-mediated fetal gene activation: The key for intervertebral disc regeneration
Supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024 - 2024/09 FETALIX® in vivo validation and process scalability
Supervisor
2024 - 2024 Trabalho exploratório para implementação de produto no mercado
Supervisor
2018 - 2023 Fetal extracellular matrix-based hydrogel for rejuvenation of Intervertebral Disc
Co-supervisor
 BiotecHealth Programme (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/10 - 2022 Hydrogels Derived from Decellularized Intestines as Platforms for Studying Colorectal Cancer
Co-supervisor
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2022 Bioengineering Integrated Master thesis entitled “Biological characterization of a decellularized nucleus pulposus (NP)-based hydrogel
Supervisor
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/02/15 - 2021/08/23 Potentiating the pro-regenerative effect of decellularized–based scaffolds for IVD regeneration by combination with MSC secretome
Supervisor
Danmarks Tekniske Universitet, Denmark

Københavns Universitet, Denmark
2021/02/15 - 2021/07 Optimization of scale-up conditions for IVD decellularization and hydrogel formation
Supervisor
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/02/01 - 2021/07 Decellularized Matrices as Platforms for Studying Cancer Cells
Co-supervisor
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - 2020 Molecularly assembled matrices as platforms for studying cancer cells
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2019 Fetal gene reprogramming through CRISPR technology
Supervisor
 Molecular and Cellular Biotechnology (Master)
Università degli Studi dell'Aquila, Italy
2018 - 2019 Injectable bilayered biomaterial releasing growth factors for periodontal tissue regeneration
Co-supervisor
 Bioestatística e Bioinformática Aplicadas à Saúde (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017 - 2018 Modulating extracellular matrix cues to recreate a pro-regenerative intervertebral disc microenvironment
Supervisor
 Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2017 - 2017 Optimization of a protocol for intervertebral disc decellularization
Supervisor
 Erasmus trainee (Scientific initiation)
Università degli Studi dell'Aquila, Italy
2014 - 2015 Characterization of the Intervertebral Disc extracellular matrix: on the path to regeneration
Supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/06/17 - Current Spine Innovation Forum: Translating Research into Real-World Solutions (2024/06/17) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

FETALDISC, LDA (FETALIX), Portugal
2023 - 2023 Palestras sobre a Dor Lombar - an event open to the public about spine health, active ageing to clarify and develop competencies to deal with day-to-day issues related to back pain, including a visit to research laboratories. (2023 - 2023)
2019 - 2019 CRISPR/Cas9: Mechanisms and Applications, Pre-SymBio (Pre-Symposium on Bioengineering) (2019 - 2019)
Symposium (Co-organisor)
 Universidade do Porto Faculdade de Engenharia, Portugal
2019 - 2019 Genome editing using CRISPR-Cas9 (2019 - 2019)
Workshop (Co-organisor)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2018 Career development opportunities for researchers and PhD students (2018 - 2018)
Workshop (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2018 i3S Postdoc Seminar Series (2017 - 2018)
Other (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2017 Writing your way into the right job – CV skills workshop (2017 - 2017)
Workshop (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2016 Careers in Science and Beyond (received the Best Event of the Year Award in 2017) (2016 - 2016)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2016 Coordinator of the project from IBMC.INEB “A time for Science - What fruitflies teach us about cancer” that envisaged explaining primary school students how Drosophila can be used as a model animal to study cancer. (2014 - 2016)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - Current Participant in the i3S workshop for primary schools, “Ai que me doem as costas” in which i3S researchers explain basic concepts about the spine and in particular about the intervertebral disc, how to treat and prevent low back pain.
2022 - Current Participant in the IBMC.INEB activity “Micro Macro Mundo”, where researchers from i3S go to kindergarden and primary schools to mitigate the fears from COVID by exploring the presence of neutral or beneficial microorganisms around us.
2015 - Current Science ambassador of IBMC.INEB with the activity “To be or not to be... a scientist!” which is a question and answer session about the scientist day-to-day work, academic path and required skills and also with the activity “What can fruitflies teach us about cancer” which aims to present and discuss the use of Drosophila as a model to study cancer.
2022 - 2022 Participant in Mostra da UP
2022 - 2022 Invited jury member of the event ¿XV Congresso Nacional Cientistas em Ação, in which primary and secondary students present their work, fostering science communication and dissemination.
2019 - 2019 Mostra da UP
2018 - 2018 Participant in “Mostra da UP”
2016 - 2016 Participant in “Mostra da UP”
2014 - 2016 Participant in the IBMC.INEB activity “Porto for Children – Fruitflies go to school”, in which researchers from IBMC and INEB went to primary schools to develop experiments with children in which the concepts of genetics, heredity were explained, using the fruitfly as an animal model.
2014 - 2014 Cancer, Science and the City, integrated in the 25th anniversary of IPATIMUP "Cancer, Science and the City"
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Câmara Municipal do Porto, Portugal
2014 - 2014 Biomedical Engineering in a Quarter of History, integrated in the 25th anniversary of INEB Biomedical Engineering in a Quarter of History
Instituto Nacional de Engenharia Biomedica, Portugal
2014 - 2014 Participant in the IBMC.INEB activity “Porto for Children – Once upon a time… the bone”, in which researchers from INEB went to primary schools to develop experiments with children concerning bone and skeletal development.
Instituto Nacional de Engenharia Biomedica, Portugal
2010 - 2010 Researchers Night, in the play “Esferas” - Teatro de Marionetas Mandrágora
2010 - 2010 Mostra da UP 2016
2010 - 2010 Attendance to the workshop "Science, Politics and Media"
Workshop
 Science, Politics and Media

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Development of an In Vitro Model of Hereditary Diffuse Gastric Cancer (HDGC): a biomarker discovery tool for improved patient management. Raquel Liliana Lopes Fernandes (Master)
2023 Development of micromaterials, containing pharmacological agents, for composite scaffold incorporation towards bone regeneration
(Thesis) Main arguer
 Júnia Rodrigues (Master)
2018 Establishment of a heterotypic 3D breast cancer model based on a vascularized porous scaffold combined with an epithelial cell-laden hydrogel
(Thesis) Main arguer
 Filipa Raquel Castro Teixeira (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 Early mesoderm specification to cardiac and hematopoietic fate
(Thesis) Main arguer
 Anastasiya Hryshkina Siarheevna (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 Expression analysis of the protein CD26 in relation to other cancer stem cell markers tumorales and functional studies in colon cancer cell lines
President of the jury
 Marta Rodríguez Quiroga (PhD)
Universidade de Vigo, Spain

Association member

Society Organization name Role
2020 - Current European Orthopaedic Research Society
2017 - Current International Society for Matrix biology (ISMB)
2016 - Current i3S Postdoc Association
2016 - Current EUROSPINE
2014 - Current International Society for Matrix biology (ISMB)
2012 - Current AOSpine
2009 - Current Sociedade Portuguesa de Biologia de Desenvolvimento (SPBD)
2018 - 2018 North American Spine Society (NASS)
2013 - 2013 Sociedade Portuguesa de Bioquímica (SPB)
2010 - 2010 European Association for Cancer Research (EACR)
2006 - 2009 British Society for Cell Biology (BSCB)
2006 - 2006 British Society for Developmental Biology (BSDB)

Conference scientific committee

Conference name Conference host
2023/09 - Current 33rd Annual Conference of the European Society for Biomaterials (ESB2023)
2022/10 - Current 5th PhDay | Building Paths: The science behind us
2021/09/05 - 2021/09/09 31st Conference of the European Society for Biomaterials (ESB 2021) – Futuring Biomaterials
2020/10/01 - 2020/10/01 3rd PhDay | Back to the Future
2019 - 2019 PhD countdown – a time for Science i3S, Porto, Portugal
2017 - 2017 6th China-Europe Symposium on Biomaterials in Regenerative Medicine Porto, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/12 - Current CRISPR technology: therapeutic applications Avanços em Oncobiologia Molecular Aplicada ao Diagnóstico e Terapêutica (Pós-Graduação) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Interview (tv / radio show)

Program Topic
2018 - 2020 Joana¿s research has been highlighted by news agencies such as RTP, TVI, Porto Canal, Antena 1, Rádio Nova, Jornal de Notícias, Expresso, Diário de Notícias, Agência Lusa and other publications from Time Out, Revista Montepio, Deco Proteste, Polígrafo, 90 segundos de Ciência, among others.

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Frontiers in Bioengineering and Biotechnology
2020 - Current eLife
2020 - Current European Cells and Materials
2017 - 2017 Molecular & Cellular Proteomics (1535-9484) American Society for Biochemistry and Molecular Biology
2015 - 2016 PLoS ONE (1932-6203) Public Library of Science

Mentoring / Tutoring

Topic Student name
2013/11/25 - Current Mentoring Program of the Higher School of Biotechnology from the Portugues Catholic University (ESB-UCP) Ana Rita da Costa Gonçalves
2023 - 2023 Mentor of the Follow-up Program of Fundação Belmiro de Azevedo for Higher Education Fellows
2022 - 2022 Mentor of ThinkBio a competition for engineering students to find entrepreneurial solutions for Bioengineering-related problems.
2021 - 2022 Mentor for the international online Global Talent Mentoring Program for developing talents in science, technology, engineering, mathematics, and medical sciences (STEMM) Thomas Ho Man Tang
2020 - 2021 Mentor of a Molecular Bioengineering Project of the Bioengineering Integrated Master Programme which aimed at deepening knowledge on the conception, development and product implementation envisioning its entrance in the market. Beatriz Sá Vinhas; Francisca Coelho; Luana Rosinha da Silva; Mariana Domingues; Tiago Martins
Distinctions

Award

2023 1st Place ETRS Best Poster Award
European Tissue Repair Society (EORS), Germany
2022 Best Poster Award for Outstanding Scientific Research in the Next Generation Treatments Category
Orthopaedic Research Society, United States

Philadelphia Spine Research Society (PSRS), United States
2021 2nd Prize in the Business Ignition Programme 2020 (participated as team member)
Business Ignition Programme (BIP), Portugal
2021 Amyris Innovation BIG Impact Award (participated as promoter)
Universidade Catolica Portuguesa Escola Superior de Biotecnologia, Portugal

Amyris Bio Products Portugal, Portugal
2020 EIT Jumpstarter 1st prize in Health (participated as promoter)
European Institute of Innovation & Technology, Hungary
2018 L'Oréal Portugal Medals of Honor for Women in Science 2018
Fundação para a Ciência e a Tecnologia, Portugal

National Commission for UNESCO, Portugal

L’Oréal Portugal, Portugal

Other distinction

2024 1st Place in the Startup Lab competition
2024 Finalist of the EIT Innostars Competition
2020 EORS Education Grant
Orthopaedic Regeneration Network (ON) Foundation, Switzerland

European Orthopaedic Research Society (EORS), Germany
2020 EORS Education Grant
Orthopaedic Regeneration Network (ON) Foundation, Switzerland

EUROSPINE The Spine Society of Europe, Switzerland
2017 Youth Travel Fund
Federation of European Biochemical Societies, United Kingdom
2017 i3S Science Ambassador Award, nominee
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 i3S Best Event of the Year Award (participated as team member)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 Travel Award
European Molecular Biology Laboratory, Germany
2014 Travel Award
International Society for Matrix Biology (ISMB), United States
2009 Honor Fell Travel Award
British Society for Cell Biology, United Kingdom
2006 Honor Fell Travel Award
British Society for Developmental Biology (BSDB), United Kingdom
2004 Best student award for the curricular year of 2003-2004
Universidade Catolica Portuguesa, Portugal
2003 Best student award for the curricular year of 2002-2003
Universidade Catolica Portuguesa, Portugal
2002 Best student award for the curricular year of 2001-2002
Universidade Catolica Portuguesa, Portugal
2001 Award for the best mark applying to university
Universidade Catolica Portuguesa, Portugal
2001 Symington Best Student Award
Symington Family Estates , Portugal