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Paula Borralho Nunes. Concluiu o(a) Título de Agregado em n/a em 2017 pelo(a) Universidade de Lisboa Faculdade de Medicina, Doutoramento em Medicina em 2009 pelo(a) Universidade de Lisboa Faculdade de Medicina e Licenciatura em Medicina em 1983 pelo(a) Universidade de Lisboa Faculdade de Medicina. É Professor Auxiliar Convidado no(a) Universidade de Lisboa e Professor Coordenador Convidado no(a) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa. Publicou 26 artigos em revistas especializadas.
Identification

Personal identification

Full name
Paula Borralho Nunes

Citation names

  • Nunes, Paula
  • Paula Borralho
  • Paula Borralho Nunes

Author identifiers

Ciência ID
E91A-B8A4-D3B9
ORCID iD
0000-0002-8556-2090

Email addresses

  • paula.b.nunes@jmellosaude.pt (Professional)

Addresses

  • Serviço de Anatomia Patológica, Hospital Cuf Descobertas, 1998-018, Lisboa, Lisboa, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Italian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2017
Concluded
 n/a (Título de Agregado)
Universidade de Lisboa Faculdade de Medicina, Portugal
"n/a" (THESIS/DISSERTATION)
 n/a
2009
Concluded
 Medicina (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"CONTRIBUIÇÃO PARA O CONHECIMENTO DA CANCERIGÉNESE NA COLITE ULCEROSA DE LONGA EVOLUÇÃO FENÓTIPO ABERRANTE DE MUCINAS E MECANISMOS RELACIONADOS COM A SUA EXPRESSÃO" (THESIS/DISSERTATION)
 aprovado com Distinção e Louvor
2007
Concluded
 Medicina (Doutoramento)
Major in Especialidade: Anatomia Patológica
Universidade de Lisboa, Portugal
"A Diferenciação Gástrica na Culite Ulcerosa de Longa Evolução. Estudo do Genótipo Afurante de Mucinas e dos Mecanismos de Sua Expressão" (THESIS/DISSERTATION)
1983
Concluded
 Medicina (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
"n/a" (THESIS/DISSERTATION)
 18
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2010/01/02 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
2009/09/01 - Current Invited Teacher Coordinator (Polytechnic Teacher) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2000/01/01 - 2007/12/31 Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Positions / Appointments

Category
Host institution 		Employer
2013 - 2014 Coordenação ou direção de centro de investigação, departamento ou equivalente Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal

Others

Category
Host institution 		Employer
1992/01/01 - 2011/12/31 Médica Anatomopatologista Hospital Garcia de Orta EPE, Portugal
2008/01/01 - 2009/12/31 Assistente Convidada de Anatomia Patológica Universidade de Lisboa Faculdade de Medicina, Portugal
1999/01/01 - 2006/10/31 Assistente Convidada de Anatomia Patológica Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Projects

Contract

Designation Funders
2018/10/01 - 2021/09/30 Implementação de um teste de diagnóstico para avaliação clínica de doentes com cancro do pulmão com base na análise proteómica das características imunológicas e do micro-ambiente do tumor.
PTDC/BTM-TEC/30088/2017
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016/07/01 - 2020/03/31 Alvos terapêuticos para o cancro da mama triplo negativo: Desenvolvimento de anticorpos mono e biespecíficos contra ligandos do Notch1
PTDC/BBB-BMD/4497/2014
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, Bruno; Santos, Francisco; Gomes, Carla Pereira; et al. "Expression of NORAD correlates with breast cancer aggressiveness and protects breast cancer cells from chemotherapy". Molecular Therapy - Nucleic Acids 33 (2023): 910-924. http://dx.doi.org/10.1016/j.omtn.2023.08.019.
    10.1016/j.omtn.2023.08.019
  2. Feakins, Roger; Borralho Nunes, Paula; Driessen, Ann; Gordon, Ilyssa O; Zidar, Nina; Baldin, Pamela; Christensen, Britt; et al. "Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper". Journal of Crohn's and Colitis (2023): http://dx.doi.org/10.1093/ecco-jcc/jjad142.
    10.1093/ecco-jcc/jjad142
  3. Cruz-Duarte, Raquel; Rebelo de Almeida, Cátia; Negrão, Magda; Fernandes, Afonso; Borralho, Paula; Sobral, Daniel; Gallego-Paez, Lina M.; et al. "Predictive and Therapeutic Implications of a Novel PLC¿1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer". Clinical Cancer Research 28 6 (2022): 1203-1216. http://dx.doi.org/10.1158/1078-0432.ccr-21-1992.
    10.1158/1078-0432.ccr-21-1992
  4. "Molecular testing in stage I–III non-small cell lung cancer: approaches and challenges". Lung Cancer (2021): http://dx.doi.org/10.1016/j.lungcan.2021.09.003.
    10.1016/j.lungcan.2021.09.003
  5. Marta Vaz Batista; Diogo Alpuim Costa; Paula Borralho; Sofia Braga. "Next-Generation Sequencing in Breast Cancer Management: A Case Report of Genomic Tumour Evolution over Time". Case Reports in Oncology (2021): 1212-1219. https://doi.org/10.1159/000517441.
    10.1159/000517441
  6. Roger Feakins; Joana Torres; Paula Borralho-Nunes; Johan Burisch; Tiago Cúrdia Gonçalves; Lissy De Ridder; Ann Driessen; et al. "ECCO Topical Review on Clinicopathological Spectrum and Differential Diagnosis of Inflammatory Bowel Disease". Journal of Crohn's and Colitis (2021): https://doi.org/10.1093/ecco-jcc/jjab141.
    10.1093/ecco-jcc/jjab141
  7. Paula Borralho. "An expert consensus to standardise the assessment of histological disease activity in Crohn's disease clinical trials.". Alimentary pharmacology & therapeutics (2021): https://doi.org/10.1111/apt.16248.
    10.1111/apt.16248
  8. Fernando Magro; Glen Doherty; Laurent Peyrin-Biroulet; Magali Svrcek; Paula Borralho; Alissa Walsh; Fatima Carneiro; et al. "ECCO Position Paper: Harmonization of the Approach to Ulcerative Colitis Histopathology". Journal of Crohn's and Colitis (2020): https://doi.org/10.1093/ecco-jcc/jjaa110.
    10.1093/ecco-jcc/jjaa110
  9. Fernando Magro; Joanne Lopes; Paula Borralho; Cláudia Camila Dias; Joana Afonso; Paula Ministro; Mafalda Santiago; et al. "Comparison of the Nancy Index With Continuous Geboes Score: Histological Remission and Response in Ulcerative Colitis". Journal of Crohn's and Colitis (2020): https://doi.org/10.1093/ecco-jcc/jjaa010.
    10.1093/ecco-jcc/jjaa010
  10. Paula Borralho. "Carcinoembryonic antigen is a sialyl Lewis x/a carrier and an E-selectin ligand in non-small cell lung cancer". International Journal of Oncology (2019): http://dx.doi.org/10.3892/ijo.2019.4886.
    10.3892/ijo.2019.4886
  11. Fernando Magro; Joanne Lopes; Paula Borralho; Susana Lopes; Rosa Coelho; José Cotter; Francisca Dias de Castro; et al. "Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels". Journal of Crohn's and Colitis (2019): https://doi.org/10.1093/ecco-jcc/jjz123.
    10.1093/ecco-jcc/jjz123
  12. Paula Borralho. "Histopathology Scoring Systems of Stenosis Associated With Small Bowel Crohn’s Disease: A Systematic Review". Gastroenterology (2019): http://dx.doi.org/10.1053/j.gastro.2019.08.033.
    10.1053/j.gastro.2019.08.033
  13. Christian Maaser; Andreas Sturm; Stephan R Vavricka; Torsten Kucharzik; Gionata Fiorino; Vito Annese; Emma Calabrese; et al. "ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications". Journal of Crohn's and Colitis 13 2 (2019): 144-164. https://doi.org/10.1093/ecco-jcc/jjy113.
    10.1093/ecco-jcc/jjy113
  14. Magali Svrcek; Paula Borralho Nunes; Vincenzo Villanacci; Laurent Beaugerie; Gerhard Rogler; Gert De Hertogh; Monika Tripathi; Roger Feakins. "Clinicopathological and Molecular Specificities of Inflammatory Bowel Disease–Related Colorectal Neoplastic Lesions: The Role of Inflammation". Journal of Crohn's and Colitis (2018): https://doi.org/10.1093/ecco-jcc/jjy132.
    10.1093/ecco-jcc/jjy132
  15. Paula Borralho. "miRNA-21 ablation protects against liver injury and necroptosis in cholestasis". Cell Death & Differentiation (2018): http://dx.doi.org/10.1038/s41418-017-0019-x.
    10.1038/s41418-017-0019-x
  16. Afonso MB; Rodrigues PM; Carvalho T; Caridade M; Borralho P; Cortez-Pinto H; Castro RE; Rodrigues CM. "Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.". (2015): http://europepmc.org/abstract/med/26201023.
    10.1042/CS20140732
  17. Paula Borralho. "Intestinal Amyloidosis in Common Variable Immunodeficiency and Rheumatoid Arthritis.". Case reports in gastrointestinal medicine (2015): http://europepmc.org/articles/PMC4553190.
    10.1155/2015/405695
  18. Paula Borralho. "Dysphagia and esophageal ulcerations in HIV patient.". Acta gastro-enterologica Belgica (2015):
  19. Langner C; Magro F; Driessen A; Ensari A; Mantzaris GJ; Villanacci V; Becheanu G; et al. "The histopathological approach to inflammatory bowel disease: a practice guide.". (2014): http://europepmc.org/abstract/med/24487791.
    10.1007/s00428-014-1543-4
  20. Figueiredo, Pedro C; Pinto-Marques, Pedro; Borralho-Nunes, Paula; Freitas, João. "Unusual cause for smoldering dysphagia". (2014): http://hdl.handle.net/10400.21/5723.
    10.1007/s00455-013-9489-2
  21. Langner, C.; Magro, F.; Driessen, A.; Ensari, A.; Mantzaris, G. J.; Villanacci, V.; Becheanu, G.; et al. "The histopathological approach to inflammatory bowel disease: a practice guide". (2014): http://hdl.handle.net/10400.21/3332.
  22. Egan, Laurence; D'Inca, Renata; Jess, Tine; Pellino, Gianluca; Carbonnel, Franck; Bokemeyer, Bernd; Harbord, Marcus; et al. "Non-colorectal intestinal tract carcinomas in inflammatory bowel disease: results of the 3rd ECCO Pathogenesis Scientific Workshop (II)". (2014): http://hdl.handle.net/10400.21/5722.
    10.1016/j.crohns.2013.04.009
  23. Magro, F.; Langner, C.; Driessen, A.; Ensari, A.; Geboes, K.; Mantzaris, G.J.; Villanacci, V.; et al. "European consensus on the histopathology of inflammatory bowel disease". Journal of Crohn's and Colitis 7 10 (2013): 827-851. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884175393&partnerID=MN8TOARS.
    10.1016/j.crohns.2013.06.001
  24. Sousa, R.G.; Figueiredo, P.C.; Pinto-Marques, P.; Meira, T.; Novais, L.A.; Vieira, A.I.; Luz, C.; Borralho, P.; Freitas, J.. "An unusual cause of pseudoachalasia: The Alport syndrome-diffuse leiomyomatosis association". European Journal of Gastroenterology and Hepatology 25 11 (2013): 1352-1357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885298522&partnerID=MN8TOARS.
    10.1097/MEG.0b013e328361dd17
  25. Figueiredo, P.C.; Pinto-Marques, P.; Borralho, P.; Freitas, J.. "Unusual Cause for Smoldering Dysphagia". Dysphagia (2013): 1-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882533743&partnerID=MN8TOARS.
    10.1007/s00455-013-9489-2
  26. Carneiro, C.; Curate, F.; Borralho, P.; Cunha, E.. "Radiographic fetal osteometry: Approach on age estimation for the portuguese population". Forensic Science International 231 1-3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880815724&partnerID=MN8TOARS.
    10.1016/j.forsciint.2013.05.039
  27. Egan, L.; D'Inca, R.; Jess, T.; Pellino, G.; Carbonnel, F.; Bokemeyer, B.; Harbord, M.; et al. "Non-colorectal intestinal tract carcinomas in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (II)". Journal of Crohn's and Colitis (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84877005469&partnerID=MN8TOARS.
    10.1016/j.crohns.2013.04.009
  28. Sousa, F.; Pedro, E.; Costa, A.C.; Marques, T.P.; Borralho, P.; Barbosa, M.P.. "A case of oesophagitis | Um caso de esofagite". Revista Portuguesa de Imunoalergologia 18 6 (2010): 585-593. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952411370&partnerID=MN8TOARS.
  29. Cajaiba, M.M.; Borralho, P.; Reyes-Múgica, M.. "The potentially lethal nature of bronchial casts: Plastic bronchitis". International Journal of Surgical Pathology 16 2 (2008): 230-232. http://www.scopus.com/inward/record.url?eid=2-s2.0-42249102050&partnerID=MN8TOARS.
    10.1177/1066896907307234
  30. Borralho, P.; Vieira, A.; Loureiro, R.; Pereira, P.M.; de Freitas, J.. "Microcarcinoids associated with diversion colitis in a patient with Crohn's disease". Journal of Crohn's and Colitis 2 3 (2008): 246-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-48949105569&partnerID=MN8TOARS.
    10.1016/j.crohns.2008.05.006
  31. Katsanos KH; Vermeire S; Christodoulou DK; Riis L; Wolters F; Odes S; Freitas J; et al. "Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study.". (2007): http://europepmc.org/abstract/med/17598963.
    10.1159/000104731
  32. Borralho, P.; Vieira, A.; Freitas, J.; Chaves, P.; Soares, J.. "Aberrant gastric apomucin expression in ulcerative colitis and associated neoplasia". Journal of Crohn's and Colitis 1 1 (2007): 35-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249022357&partnerID=MN8TOARS.
    10.1016/j.crohns.2007.06.006
  33. Ramalho, M.; Cyrne, C.; Bagulho, C.; Pinho, J.; Borralho, P.. "Cavernous hemangioma in the uterine wall in gravid uterus: MRI diagnosis | Hémangiome caverneux de la paroi utérine dans un utérus gravide: Diagnostic en IRM". Imagerie de la Femme 17 4 (2007): 269-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349028871&partnerID=MN8TOARS.
    10.1016/S1776-9817(07)78173-7
  34. Freitas, J.; Farricha, V.; Nascimento, I.; Borralho, P.; Paramés, A.. "Rofecoxib: A possible cause of acute colitis". Journal of Clinical Gastroenterology 34 4 (2002): 451-453. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036207821&partnerID=MN8TOARS.
    10.1097/00004836-200204000-00015
  35. Gomes, H.; Lebre, R.; Fonseca, J.; Borralho, P.; Duarte, R.. "Adenocarcinoma of Vater's Ampulla associated with Von Recklinghausen's Neurofibromatosis | Adenocarcinoma da ampola de vater associado com neurofibromatose de von recklinghausen". Acta Medica Portuguesa 10 11 (1997): 833-836. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031263741&partnerID=MN8TOARS.
  36. Da Fonseca, J.; Goncalves, F.; Freitas, J.; Borralho, P.; Leal, C.. "Aortoesophageal fistula of unusual location". Endoscopy 29 2 (1997): 138-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030963348&partnerID=MN8TOARS.
  37. Borralho, P.; Cunha, F.; Pinto, M.; Torrado Da Silva, A.; Meirinho, M.. "Perinatal morbidity and mortality related to gestational infection-histological identification of chorioamnionitis and its incidence in a studied population | Morbilidade e mortalidade perinatal relacionadas com a infecção na gestação: Identificação histológica da corioamnionite e sua incidência na População estudada". Acta Medica Portuguesa 9 10-12 (1996): 319-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030252968&partnerID=MN8TOARS.
Report
  1. Nunes,Ana; Vieira,Ana; Borralho,Paula; Ramalho,Miguel; Freitas,João de. 2013. Linfoma intestinal em doente tratada com metotrexato (caso clínico). http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0872-81782013000100006.
Thesis / Dissertation
  1. Lopes, Diogo José Martins. "Doença Celíaca". Master, 2018. http://hdl.handle.net/10400.6/8477.
  2. Borrecho, Gonçalo Luís Vieira. "Verificação de indicadores da qualidade na fase analítica laboratorial em anatomia patológica: análise a 21 laboratórios Portugueses". Master, 2018. http://hdl.handle.net/10400.21/11557.
  3. Nunes, Paula Maria Ferreira Brinca Borralho, 1959-. "Contribuição para o conhecimento da cancerigénese na colite ulcerosa de longa evolução : fenótipo aberrante de mucinas e mecanismos relacionados com a sua expresão". PhD, 2009. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000570063.
Activities

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2009 - Current Biopatologia
Distinctions

Award

2019 Prémio Pfizer da Medicina
Laboratórios Pfizer Ltda, Brazil