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Margarida Saraiva obtained a degree in Biochemistry (Hons) in 1997, by Faculdade de Ciências da Universidade do Porto, Portugal. After 4 years (1999-2002) of research on Poxvirus Immune Evasion, in Antonio Alcami's lab, Margarida Saraiva obtained a PhD in Pathology awarded by the University of Cambridge, UK, and moved to Anne O'Garra's lab, at the MRC-National Institute for Medical Research (London). During her post-doc, Margarida Saraiva investigated the molecular mechanisms that regulate the expression of Interleukin-10 by immune cells. In 2007, Margarida Saraiva returned to Portugal and joined the Life and Health Sciences Research Institute (ICVS) at Universidade do Minho, as a Ciência 2007 fellow, to study several cellular and molecular mechanisms in place during the innate immune response to mycobacteria. From June 2015, Margarida Saraiva became a group leader at IBMC-Porto to study the molecular mechanisms underlying immune regulation using deregulated myelopoiesis and tuberculosis as disease models. Margarida Saraiva has published over 70 articles in peer-reviewed journals, gathering over 5200 citations; successfully supervised several MSc, PhD and Post-doctoral fellows; has been PI in several competitive funded grants; has been invited speaker in various international conferences and institutes; and has been awarded several national and international prizes for her research. Margarida Saraiva served as President of the Portuguese Society for Immunology between 2018-2021.
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Identification

Personal identification

Full name
Margarida Saraiva

Citation names

  • Saraiva, Margarida

Author identifiers

Ciência ID
E913-D1B0-CEB1
ORCID iD
0000-0002-8180-1293
Scopus Author Id
35079223500

Email addresses

  • margarida.saraiva@ibmc.up.pt (Professional)

Addresses

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English (Mother tongue)
Education
Degree Classification
2003
Concluded
 Doutoramento em Patologia (Doutoramento)
University of Cambridge Murray Edwards College, United Kingdom
"Immunomodulatory molecules encoded by poxviruses- TNF receptor homologues." (THESIS/DISSERTATION)
 aprovado por unanimidade
1997
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2015/06/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/05/01 - 2015/05/30 Principal Investigator (Research) Universidade do Minho, Portugal
Laboratório Associado ICVS 3B's, Portugal
2007/04/01 - 2013/04/30 Auxiliary Researcher (Research) Universidade do Minho, Portugal
Laboratório Associado ICVS 3B's, Portugal
2006/01/03 - 2007/03/31 Invited Auxiliary Researcher (Research) National Institute for Medical Research, United Kingdom
2003/01/03 - 2005/12/31 Postdoc (Research) National Institute for Medical Research, United Kingdom
1997/09/01 - 1998/12/31 Research Trainee (Research) Universidade do Porto, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Grant

Designation Funders
2021/03/01 - Current Host-microbiome interactions in the quest for Fibrosing ILD Biomarkers that Rule Acceleration (FIBRA-Lung)
PTDC/MEC-RES/0158/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09/15 - 2025/09/15 A multidisciplinary approach to understand host and pathogen interactions to develop new strategies to target TB
HR21-00415
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 La Caixa Research Foundation
Ongoing
2022/01/01 - 2025/05/30 Deciphering the immune mechanisms of tuberculosis disease severity through host-pathogen interactions
PTDC/SAU-INF/1172/2021
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/08/27 - 2021/08/26 Understanding host-pathogen interactions in tuberculosis: lessons from Mycobacterium africanum.
Maf_TB
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia

Aga Khan Foundation
Ongoing
2018/06/01 - 2021/05/31 Molecular stratification of latent tuberculosis: a persisting memory?
POCI-01-0145-FEDER-028955
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014/09/01 - 2017/04/01 Deregulation of hematopoiesis by IL-10: implications for the development of hematologic diseases
FCT-ANR/BIM-MEC/0007/2013
Principal investigator
Laboratório Associado ICVS 3B's, Portugal

Institut Pasteur, France
Concluded
2010/03/01 - 2013/02/28 Molecular mechanisms underlying regulation of IL-12 family of cytokines expression on macrophages and dendritic cells infected by Mycobacterium tuberculosis
PTDC- BIA-BCM/102776/2008
Principal investigator
Laboratório Associado ICVS 3B's, Portugal
Concluded

Contract

Designation Funders
2019/03/01 - 2025/02/28 Deciphering host-pathogen interactions to understand tuberculosis
CEECIND/00241/2017
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2021/03/01 - 2024/02/29 Interações hospedeiro-microbioma na busca por biomarcadores de doenças pulmonares intersticiais fibrosantes que regem a aceleração FIBRA-Lung<br>
PTDC/MEC-RES/0158/2020
Centro Hospitalar Universitário de São João, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book
  1. Gabryšová, L.; Howes, A.; Saraiva, M.; O'Garra, A.. The regulation of IL-10 expression. 2014.
    10.1007/978-3-662-43492-5-8
  2. Gabryšová, L.; Howes, A.; Saraiva, M.; O'Garra, A.. The regulation of IL-10 expression. 2014.
    10.1007/978-3-662-43492-5_8
  3. Alcami, A.; Saraiva, M.. Chemokine binding proteins encoded by pathogens. 2009.
    10.1007/978-1-4419-1601-3_13
Journal article
  1. Branchett, William J; Saraiva, Margarida; O’Garra, Anne. "Regulation of inflammation by Interleukin-10 in the intestinal and respiratory mucosa". Current Opinion in Immunology 91 (2024): 102495. https://doi.org/10.1016/j.coi.2024.102495.
    10.1016/j.coi.2024.102495
  2. Ana Isabel Fernandes; Alexandre Jorge Pinto; Diogo Silvério; Ulrike Zedler; Carolina Ferreira; Iola F Duarte; Ricardo Silvestre; Anca Dorhoi; Margarida Saraiva. "Genetically Diverse Mycobacterium tuberculosis Isolates Manipulate Inflammasome and Interleukin 1ß Secretion Independently of Macrophage Metabolic Rewiring". The Journal of Infectious Diseases (2024): https://doi.org/10.1093/infdis/jiae583.
    10.1093/infdis/jiae583
  3. Cardoso, Marcos S.; Gonçalves, Rute; Oliveira, Liliana; Silvério, Diogo; Téllez, Érica; Paul, Tony; Sarrias, Maria Rosa; Carmo, Alexandre M.; Saraiva, Margarida. "CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression". Immunology (2024): http://dx.doi.org/10.1111/imm.13825.
    Published • 10.1111/imm.13825
  4. Silva, Ana Isabel; Socodato, Renato; Pinto, Carolina; Terceiro, Ana Filipa; Canedo, Teresa; Relvas, João Bettencourt; Saraiva, Margarida; Summavielle, Teresa. "IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methamphetamine-induced neuroinflammation". Glia (2024): http://dx.doi.org/10.1002/glia.24542.
    10.1002/glia.24542
  5. Maceiras, Ana Raquel; Silvério, Diogo; Gonçalves, Rute; Cardoso, Marcos S.; Saraiva, Margarida. "Infection with hypervirulent Mycobacterium tuberculosis triggers emergency myelopoiesis but not trained immunity". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1211404.
    10.3389/fimmu.2023.1211404
  6. Couto, Joana; Gonçalves, Rute; Lamas, Sofia; Saraiva, Margarida. "Protocol for infecting and monitoring susceptible k18-hACE2 mice with SARS-CoV-2". STAR Protocols 4 2 (2023): 102303. http://dx.doi.org/10.1016/j.xpro.2023.102303.
    10.1016/j.xpro.2023.102303
  7. Gomes, Ana Cordeiro; Sousa, Daniela Monteiro; Oliveira, Tiago Carvalho; Fonseca, Óscar; Pinto, Ricardo J.; Silvério, Diogo; Fernandes, Ana Isabel; et al. "Serum amyloid A proteins reduce bone mass during mycobacterial infections". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1168607.
    10.3389/fimmu.2023.1168607
  8. Saraiva, Maria João; Moreira, João; Martins, Helena; Saraiva, Margarida. "TLR2 and 4 signaling pathways are altered in macrophages from V30M TTR mice with downregulated expression of chemokines". Clinical Science (2023): http://dx.doi.org/10.1042/cs20220656.
    10.1042/cs20220656
  9. Gonçalves, Rute; Couto, Joana; Ferreirinha, Pedro; Costa, José Maria; Silvério, Diogo; Silva, Marta L.; Fernandes, Ana Isabel; et al. "SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice". iScience 26 2 (2023): 105972. http://dx.doi.org/10.1016/j.isci.2023.105972.
    10.1016/j.isci.2023.105972
  10. Marta L. Silva; Antje Blumenthal; Baltazar Cá; Nuno S. Osório; Pedro N. S. Rodrigues; Ana Raquel Maceiras; Margarida Saraiva. "Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns". PLOS Pathogens (2022): https://doi.org/10.1371/journal.ppat.1010490.
    10.1371/journal.ppat.1010490
  11. Diogo Silvério; Rute Gonçalves; Rui Appelberg; Margarida Saraiva; Murugesan V. S. Rajaram; Jacob Yount. "Advances on the Role and Applications of Interleukin-1 in Tuberculosis". mBio 12 6 (2021): https://doi.org/10.1128/mBio.03134-21.
    10.1128/mBio.03134-21
  12. Rocha, Deisy M. G. C.; Viveiros, Miguel; Saraiva, Margarida; Osório, Nuno S.. "The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem". Genes 12 12 (2021): 2003. http://dx.doi.org/10.3390/genes12122003.
    10.3390/genes12122003
  13. Cardoso, Ana; Martins, Ana Catarina; Maceiras, Ana Raquel; Liu, Wei; Castro, Isabel; Castro, António G.; Bandeira, António; et al. "Interleukin-10 induces interferon-¿-dependent emergency myelopoiesis". Cell Reports 37 4 (2021): 109887. http://dx.doi.org/10.1016/j.celrep.2021.109887.
    10.1016/j.celrep.2021.109887
  14. Rocha, Deisy M. G. C.; Magalhães, Carlos; Cá, Baltazar; Ramos, Angelica; Carvalho, Teresa; Comas, Iñaki; Guimarães, João Tiago; et al. "Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis Strains From the Same Transmission Cluster". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.659545.
    10.3389/fmicb.2021.659545
  15. Moreira, João; Costelha, Susete; Saraiva, Margarida; Saraiva, Maria João. "The Expression of Chemokines Is Downregulated in a Pre-Clinical Model of TTR V30M Amyloidosis". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.650269.
    10.3389/fimmu.2021.650269
  16. Matos, Rita; Fonseca, Kaori L.; Mereiter, Stefan; Maceiras, Ana Raquel; Gomes, Joana; Vilaplana, Cristina; Gartner, Fátima; et al. "Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium". Microorganisms 9 1 (2021): 99. http://dx.doi.org/10.3390/microorganisms9010099.
    Published • 10.3390/microorganisms9010099
  17. Moreira-Teixeira, Lúcia; Stimpson, Philippa J.; Stavropoulos, Evangelos; Hadebe, Sabelo; Chakravarty, Probir; Ioannou, Marianna; Aramburu, Iker Valle; et al. "Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19412-6.
    Open access • Published • 10.1038/s41467-020-19412-6
  18. Gomes, Ana Cordeiro; Saraiva, Margarida; Gomes, Maria Salomé. "The bone marrow hematopoietic niche and its adaptation to infection.". Seminars in cell & developmental biology (2020): https://doi.org/10.1016/j.semcdb.2020.05.014.
    10.1016/j.semcdb.2020.05.014
  19. Jeremy Sousa; Baltazar Cá; Ana Raquel Maceiras; Luisa Simões-Costa; Kaori L. Fonseca; Ana Isabel Fernandes; Angélica Ramos; et al. "Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production". Nature Communications 11 (2020): 1949. https://www.nature.com/articles/s41467-020-15832-6.pdf.
    In press • 10.1038/s41467-020-15832-6
  20. Moreira-Teixeira, Lúcia; Tabone, Olivier; Graham, Christine M.; Singhania, Akul; Stavropoulos, Evangelos; Redford, Paul S.; Chakravarty, Probir; et al. "Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis". Nature Immunology 21 4 (2020): 464-476. http://dx.doi.org/10.1038/s41590-020-0610-z.
    Published • 10.1038/s41590-020-0610-z
  21. Fonseca, Kaori L.; Maceiras, Ana Raquel; Matos, Rita; Simoes-Costa, Luisa; Sousa, Jeremy; Cá, Baltazar; Barros, Leandro; et al. "Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils". Mucosal Immunology (2020): http://dx.doi.org/10.1038/s41385-020-0277-7.
    Open access • Published • 10.1038/s41385-020-0277-7
  22. Mariana Resende; Catarina M. Ferreira; Ana Margarida Barbosa; Marcos S. Cardoso; Jeremy Sousa; Margarida Saraiva; António G. Castro; Rui Appelberg; Egídio Torrado. "Myeloid HIF-1a regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection". Immunology (2020): https://doi.org/10.1111/imm.13131.
    10.1111/imm.13131
  23. Saraiva, Margarida; Vieira, Paulo; O’Garra, Anne. "Biology and therapeutic potential of interleukin-10". The Journal of Experimental Medicine 217 1 (2019): http://dx.doi.org/10.1084/jem.20190418.
    10.1084/jem.20190418
  24. Dorhoi A; Glaría E; Garcia-Tellez T; Nieuwenhuizen NE; Zelinskyy G; Favier B; Singh A; et al. "MDSCs in infectious diseases: regulation, roles, and readjustment.". Cancer immunology, immunotherapy : CII (2018): http://europepmc.org/abstract/med/30569204.
    10.1007/s00262-018-2277-y
  25. Sousa J; Saraiva M. "Paradigm changing evidence that alter tuberculosis perception and detection: Focus on latency.". Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (2018): http://europepmc.org/abstract/med/30576838.
    10.1016/j.meegid.2018.12.019
  26. Bhatt K; Machado H; Osório NS; Sousa J; Cardoso F; Magalhães C; Chen B; et al. "A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.". mSphere (2018): http://europepmc.org/abstract/med/30381350.
    10.1128/mSphere.00352-18
  27. Gaifem J; Gonçalves LG; Dinis-Oliveira RJ; Cunha C; Carvalho A; Torrado E; Rodrigues F; et al. "L-Threonine Supplementation During Colitis Onset Delays Disease Recovery.". Frontiers in physiology (2018): http://europepmc.org/abstract/med/30233416.
    10.3389/fphys.2018.01247
  28. Bruger AM; Dorhoi A; Esendagli G; Barczyk-Kahlert K; van der Bruggen P; Lipoldova M; Perecko T; et al. "How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions.". Cancer immunology, immunotherapy : CII (2018): http://europepmc.org/abstract/med/29785656.
    10.1007/s00262-018-2170-8
  29. Alejo A; Ruiz-Argüello MB; Pontejo SM; Fernández de Marco MDM; Saraiva M; Hernáez B; Alcamí A. "Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation.". Nature communications (2018): http://europepmc.org/abstract/med/29724993.
    10.1038/s41467-018-04098-8
  30. Cardoso A; Gil Castro A; Martins AC; Carriche GM; Murigneux V; Castro I; Cumano A; Vieira P; Saraiva M. "The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/29545807.
    10.3389/fimmu.2018.00400
  31. Bastos HN; Osório NS; Gagneux S; Comas I; Saraiva M. "The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes.". Frontiers in immunology (2017): http://europepmc.org/abstract/med/29375571.
    10.3389/fimmu.2017.01948
  32. Fonseca, K.L.; Rodrigues, P.N.S.; Olsson, I.A.S.; Saraiva, M.. "Experimental study of tuberculosis: From animal models to complex cell systems and organoids". PLoS Pathogens 13 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85028681914&partnerID=MN8TOARS.
    10.1371/journal.ppat.1006421
  33. Cunha, C.; Gonçalves, S.M.; Duarte-Oliveira, C.; Leite, L.; Lagrou, K.; Marques, A.; Lupiañez, C.B.; et al. "IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity". Journal of Allergy and Clinical Immunology 140 3 (2017): 867-870.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019152778&partnerID=MN8TOARS.
    10.1016/j.jaci.2017.02.034
  34. Gonçalves, N.P.; Moreira, J.; Martins, D.; Vieira, P.; Obici, L.; Merlini, G.; Saraiva, M.; Saraiva, M.J.. "Differential expression of Cathepsin E in transthyretin amyloidosis: From neuropathology to the immune system". Journal of Neuroinflammation 14 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85020206626&partnerID=MN8TOARS.
    10.1186/s12974-017-0891-9
  35. Domingues, N.; Estronca, L.M.B.B.; Silva, J.; Encarnação, M.R.; Mateus, R.; Silva, D.; Santarino, I.B.; et al. "Cholesteryl hemiesters alter lysosome structure and function and induce proinflammatory cytokine production in macrophages". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1862 2 (2017): 210-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999089924&partnerID=MN8TOARS.
    10.1016/j.bbalip.2016.10.009
  36. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Interferon-ß regulates the production of IL-10 by toll-like receptor-activated microglia". GLIA 65 9 (2017): 1439-1451. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021258982&partnerID=MN8TOARS.
    10.1002/glia.23172
  37. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.. "Balancing the immune response in the brain: IL-10 and its regulation". Journal of Neuroinflammation 13 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997106994&partnerID=MN8TOARS.
    10.1186/s12974-016-0763-8
  38. Moreira-Teixeira, L.; Sousa, J.; McNab, F.W.; Torrado, E.; Cardoso, F.; Machado, H.; Castro, F.; et al. "Type i IFN inhibits alternative macrophage activation during mycobacterium tuberculosis infection and leads to enhanced protection in the absence of IFN-¿ signaling". Journal of Immunology 197 12 (2016): 4714-4726. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002328285&partnerID=MN8TOARS.
    10.4049/jimmunol.1600584
  39. Stucki, D.; Brites, D.; Jeljeli, L.; Coscolla, M.; Liu, Q.; Trauner, A.; Fenner, L.; et al. "Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages". Nature Genetics 48 12 (2016): 1535-1543. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992759009&partnerID=MN8TOARS.
    10.1038/ng.3704
  40. Howes, A.; Taubert, C.; Blankley, S.; Spink, N.; Wu, X.; Graham, C.M.; Zhao, J.; et al. "Differential production of Type I IFN Determines the Reciprocal Levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages". Journal of Immunology 197 7 (2016): 2838-2853. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989939029&partnerID=MN8TOARS.
    10.4049/jimmunol.1501923
  41. Bastos, H.N.; Osório, N.S.; Castro, A.G.; Ramos, A.; Carvalho, T.; Meira, L.; Araújo, D.; et al. "A prediction rule to stratify mortality risk of patients with pulmonary tuberculosis". PLoS ONE 11 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992386220&partnerID=MN8TOARS.
    10.1371/journal.pone.0162797
  42. Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells". Vaccine 33 1 (2015): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=MN8TOARS.
    10.1016/j.vaccine.2014.11.013
  43. Carvalho, A.; Costa, P.; Triunfante, V.; Branca, F.; Rodrigues, F.; Santos, C.L.; Correia-Neves, M.; et al. "Analysis of a local HIV-1 epidemic in portugal highlights established transmission of Non-B and Non-G subtypes". Journal of Clinical Microbiology 53 5 (2015): 1506-1514. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928032043&partnerID=MN8TOARS.
    10.1128/JCM.03611-14
  44. Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
    10.3389/fimmu.2015.00498
  45. Cardoso, F.; Castro, F.; Moreira-Teixeira, L.; Sousa, J.; Torrado, E.; Silvestre, R.; Castro, A.G.; Saraiva, M.; Pais, T.F.. "Myeloid sirtuin 2 expression does not impact long-term Mycobacterium tuberculosis control". PLoS ONE 10 7 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940426429&partnerID=MN8TOARS.
    10.1371/journal.pone.0131904
  46. Teixeira-Coelho, M.; Guedes, J.; Ferreirinha, P.; Howes, A.; Pedrosa, J.; Rodrigues, F.; Lai, W.S.; et al. "Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages". European Journal of Immunology 44 3 (2014): 856-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896030127&partnerID=MN8TOARS.
    10.1002/eji.201343734
  47. McNab, F.W.; Ewbank, J.; Howes, A.; Moreira-Teixeira, L.; Martirosyan, A.; Ghilardi, N.; Saraiva, M.; O'Garra, A.. "Type i IFN induces IL-10 production in an IL-27-Independent manner and blocks responsiveness to IFN-¿ for production of IL-12 and bacterial killing in mycobacterium tuberculosis-infected macrophages". Journal of Immunology 193 7 (2014): 3600-3612. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907215689&partnerID=MN8TOARS.
    10.4049/jimmunol.1401088
  48. McNab, F.W.; Ewbank, J.; Rajsbaum, R.; Stavropoulos, E.; Martirosyan, A.; Redford, P.S.; Wu, X.; et al. "TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production". Journal of Immunology 191 4 (2013): 1732-1743. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881454396&partnerID=MN8TOARS.
    10.4049/jimmunol.1300146
  49. Osório, N.S.; Rodrigues, F.; Gagneux, S.; Pedrosa, J.; Pinto-Carbó, M.; Castro, A.G.; Young, D.; Comas, I.; Saraiva, M.. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure". Molecular Biology and Evolution 30 6 (2013): 1326-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727980&partnerID=MN8TOARS.
    10.1093/molbev/mst038
  50. Carmona, J.; Cruz, A.; Moreira-Teixeira, L.; Sousa, C.; Sousa, J.; Osorio, N.S.; Saraiva, A.L.; et al. "Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879468975&partnerID=MN8TOARS.
    10.1371/journal.pone.0067277
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Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/18 Genetically diverse M. tuberculosis clinical isolates modulate IL-1ß responses with an impact on the outcome of infection Tuberculosis: Heterogeneity from Experimental Models to Human Disease
Keystone symposium (Boston, United States)
2024/03/05 Mycobacterium tuberculosis diversity: what is it teaching us 27. Symposium: “Infection and Immune Defense“ - German Society for Immunology
German Society for Immunology - Study Group Infection Immunology (Germany)
2023/12 TB-spectrum: laboratory markers in connection with clinical significance Training school of the Advance-TB COST Action
2023/06 Study of host pathogen interactions in TB using in clinico to in vitro to in vivo approaches- What can we learn? European Society of Mycobacteriology
(Albania)
2023/03/19 Tuberculosis basic Biology- using Mycobacterium tuberculosis diversity to understand tuberculosis Tuberculosis symposium
Basel TPH (Basel, Switzerland)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/01 - Current Redefining IL-10-based therapies
Supervisor
2021/01/01 - Current Understanding tuberculosis infection and disease progression using Mycobacterium africanum as a model
Supervisor
 PhD (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09/01 - Current Understanding the molecular bases dictating TB severity
Supervisor
 PhD in Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/01 - 2026/12/31 Deciphering the contribution of the epithelium to tuberculosis severity: from alveolar epithelial cells to epithelioid macrophages
Supervisor
 PhD in Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/01/01 - 2026/12/31 Improved predictive models for SARS-CoV-2 infection
Co-supervisor
 PhD in Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/09/01 - 2024/01 Exploring Mycobacterium tuberculosis immune evasion strategies to improve host immunity and tuberculosis outcome: the IL-1 axis
Supervisor
 Doutoramento em Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/01 - 2023/09/25 Decoding the mechanisms linking IL-10-driven to cellular senescence and aging
Supervisor
 Doutoramento em Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/09/01 - 2022/12/03 Deciphering the in vivo mechanisms underlying the IL-10-mediated differentiation of IFNg-producing T cells
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2021/09/01 - 2022/12/03 Understanding the impact of the Mycobacterium tuberculosis complex diversity in tuberculosis
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2021/09/01 - 2022/09/01 Understanding the modulation of myeloid cell responses by clinical isolates of Mycobacterium tuberculosis associated with mild or severe tuberculosis
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09/01 - 2021/12/03 Interleukin 1 manipulation by Mycobacterium tuberculosis : impact to the infection establishment and progression
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2016/01/01 - 2020/03/04 Impact of Host Glycosylation in Tuberculosis
Supervisor
 Doutoramento em Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/10/01 - 2020/01/28 UNDERSTANDING HOST-PATHOGEN INTERACTIONS IN TUBERCULOSIS: LESSONS FROM MYCOBACTERIUM AFRICANUM
Supervisor
 Doutoramento em Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/11/01 - 2020/01/14 THE YIN AND YAN OF HOST-PATHOGEN INTERACTIONS IN TUBERCULOSIS
Supervisor
 Doutoramento em Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2019 The impact of Mycobacterium tuberculosis diversity to the course of infection
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/01/01 - 2018/07/19 Impact of regulatory cytokines in hematopoiesis
Supervisor
 Doutoramento em Ciências da Saúde (PhD)
Universidade do Minho Escola de Medicina, Portugal
2013/01/01 - 2017/04/17 IDENTIFICATION OF HUMAN AND PATHOGEN MOLECULAR VARIANTS ASSOCIATED TO TUBERCULOSIS HETEROGENEITY
Supervisor
 Doutoramento em Medicina (PhD)
Universidade do Minho Escola de Medicina, Portugal
2016 - 2017 Decoding the role of IL-10 in aging
Supervisor
Universidade do Minho Escola de Ciências, Portugal
2016 - 2017 Funtional impact of differential IL-1 signaling in tuberculosis
Supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2016 IL-10 overexpression drives myelopoiesis and premature aging
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2015 The mechanisms underlying Mycobacterium tuberculosis virulence granted by the nrp gene
Supervisor
Universidade do Minho Escola de Medicina, Portugal
2014 - 2015 Impact of IL-10 over-expression in dextran sodium sulfate induced acute and chronic colitis
Supervisor
Universidade do Minho Escola de Medicina, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/07/01 - Current Invited speaker @ the 2018 Annual Meeting of the European Society for Mycobacteriology
Congress
 Annual Meeting of the European Society for Mycobacteriology
2018 - Current Invited speaker @ The Francis Crick Institute, London
Seminar
2017/03/04 - Current Invited speaker @ the 2017 EFIS on the road symposium
Symposium
 Meeting of the European Federation of Immunological Societies
2017 - Current Invited speaker @ Max Plank Institute for Infection, Berlin
Seminar
 Invited seminar - Max Plank Institute for Infection
2022/10/22 - 2022/10/22 Invited speaker at the Innovate4TB annual meeting
Congress
2022/06/22 - 2022/06/22 Invited speaker at the Inflammazoom seminar series
Conference
2022/04/20 - 2022/04/20 Invited speaker at the Annual Meeting of the Portuguese Society for Immunology 2022
Congress
2021/06/07 - 2021/06/07 Invited speaker at IMM seminar series
Conference
2020/10/03 - 2020/10/03 Invited speaker at TB-Science 2020
Conference
2020/06/04 - 2020/06/04 Invited speaker at the IGC seminar series
Conference

Committee member

Activity description
Role 		Institution / Organization
2020/02/01 - Current Member of the Scientific Advisory Board for a H2020 project
Member
2020 - Current Member of the Scientific Advisory Board of the PhD program Molecular and Cellular Biology
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/06/05 - Current President of the Portuguese Society for Immunology
President / Vice-president
 Sociedade Portuguesa de Imunologia, Portugal
2024/01 - 2026/12 Member of the Scientific Council of the Jerome Lejeune foundation
Advisor / Consultant
 Fondation Jérôme Lejeune, France
2022/10/01 - 2025/09/30 Management Committee and Work Group Leader - COST Action TB Advance
Member
 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Spain
2020/01/01 - 2024/01/01 Scientific Advisory Board Member- EU project SMA-TB
Advisor / Consultant
 Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Spain
2015/06/01 - 2018/12/30 Member of the management committee of the COST Action MyeEUNITER
Member

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/06/14 - 2033/06/15 Member of the Life Sciences panel for the La Caixa PhD fellowships.
Evaluator
 La Caixa Research Foundation, Spain
2024/06/01 - 2024/10 Co-coordinator of the Experimental Biology panel of the FCT PhD fellowships call
Coordinator

Journal scientific committee

Journal title (ISSN) Publisher
2015/04/01 - Current Immunity Inflammation and Disease (2050-4527) Wiley (John Wiley & Sons)

Other jury / evaluation

Activity description Institution / Organization
2014 - 2015 Member of the Evaluation panel for PhD and Post-doctoral fellowships - FCT Fundação para a Ciência e a Tecnologia, Portugal
Distinctions

Other distinction

2021 Testing and defining the correlates of protection to a new inhaled COVID-19 vaccine.
British Society for Antimicrobial Chemotherapy, United Kingdom
2018 Host prognostic markers of effective Mycobacterium tuberculosis infection in latency.
British Society for Antimicrobial Research , United Kingdom
2018 Janssen Award for Innovation – Honorable distinction: The anti-inflammatory cytokine IL-10 is a new determinant of hematopoietic lineage commitment. 2018.
2015 2015 Research Grant from the European Society for Clinical Microbiology and Infectious Diseases (ESCMID)- Deciphering the candidate Mycobacterium tuberculosis molecular signatures of TLR2 vs TLR4 activation.
2013 Fundação Amélia de Mello/José de Mello Saúde Prize for clinical research
2013 Royal Academy of Sciences Exchange Research Prize
2011 ICVS-Incentive to Reseach