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Bruno Sarmento is Principal Investigator, Group Leader and member of the Board of Directors at Institute for Research and Innovation in Health (i3S), University of Porto (UP), and Invited Associate Professor at Instituto Universitário de Ciências da Saúde (IUCS), Portugal. He graduated in Pharmaceutical Sciences at the University of Porto (PT) in 2002 and completed a PhD in Pharmaceutical Nanotechnology at UP in 2007, in collaboration with Queen’s University (CA), University of Copenhagen (DK) and University of Santiago de Compostela (ES). From 2007 to 2012 he held a Post-Doc position at UP, in collaboration with the University of Copenhagen. In 2008 he was appointed Assistant Professor at IUCS. He also co-founded Inovapotek in 2008, and is member of its advisory board. In 2012 he became Associated Researcher at INEB, where established an independent team. He was appointed as Assistant Researched at INEB/i3S in 2016, and Principal Investigator in 2019. He was Visiting Professor ay, UniOeste (BR) and Visiting Research Professor at Queen’s University, Belfast (UK). So far, he has supervised/co-supervised 14 Post-Docs (12 completed), 45 PhD students (34 completed) and 38 MSc students (35 completed), and 13 researcher assistants. He attracted direct competitive funding worth more than 15 M€, at national and international levels. His current research is focused on the development of functionalized nanomedicines and their application in the pharmaceutical and biomedical fields. In particular, nanoformulations of biopharmaceutical drugs with interest in diabetes, cancer and infectious diseases. He has also specialized in mucosal tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He published 400 papers in international journals, most in top journals (Q1 in Pharmaceutical Sciences; Q1 in Nanoscience and Nanotechnology; total citations in Scopus 13200; H-index 57 and in GoogleScholar 17720; H-index 67), 54 book chapters and more than 350 proceedings. He edited 5 books, participated in more than 50 invited/selected talks in national and international meetings and was awarded several distinctions. He is editor of European Journal of Pharmaceutical Sciences, and member of the Editorial Advisory Board of 11 international journals, including the Journal of Controlled Release, Expert Opinion on Drug Delivery and Pharmaceutics. He has acted as referee for top-ranked journals in his area of expertise, and for international funding agencies: FNRS (BE), Inserm (FR), CNCS (RO), FCT (PT), Foncyt (ARG), CNPq (BR) and European Commission. Bruno Sarmento was the first Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society (CRS) and is now Director-at-Large of CRS and member of CRS Collegue of Fellows. In addition to being a partner in several research projects, he was the PI of competitively funded projects (FCT, Gilead and CESPU), PI of different bilateral collaborative projects between Portugal (FCT) and foreigner funding agencies as well as partner of several European projects funded by European Commission.
Identification

Personal identification

Full name
Bruno Sarmento

Citation names

  • Sarmento, Bruno

Author identifiers

Ciência ID
E816-B6B0-06A5
ORCID iD
0000-0001-5763-7553
Scopus Author Id
14014524100

Knowledge fields

  • Engineering and Technology - Industrial Biotechnology - Bioproducts Biomaterials
  • Engineering and Technology - Nano-technology - Nano-materials
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Italian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2004/01/01 - 2007/10/18
Concluded
Pharmaceutical Sciences (Doutoramento)
Major in Pharmaceutical Technology
Universidade do Porto Faculdade de Farmácia, Portugal
"Improvement of Peptidic Drugs Oral Availability Througt Their Encapsulation in Polyelectrolytes Complexes - Made Nano Particles" (THESIS/DISSERTATION)
2002
Concluded
Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
15
Affiliation

Science

Category
Host institution
Employer
2019/03 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/05/01 - 2019/03/15 Auxiliary Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01/01 - 2016/04/30 Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2004/01/01 - 2007/10/18 Researcher (Research) Universidade do Porto Faculdade de Farmácia, Portugal
2004/01/01 - 2004/12/31 Visiting Researcher (Research) Queen's University, Canada

Teaching in Higher Education

Category
Host institution
Employer
2020 - Current Invited Associate Professor (University Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2008/03/01 - 2020/12/31 Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2015/01/01 - 2017/12/31 Visiting Professor (University Teacher) Universidade Estadual do Oeste do Paraná, Brazil

Positions / Appointments

Category
Host institution
Employer
2020/01 - Current Editor Annals of the Brazilian Academy of Sciences, Brazil
Annals of the Brazilian Academy of Sciences, Brazil
2020 - Current Chair of the International Chapter Committee of the Controlled Release Society Controlled Release Society, United States
2019/12 - Current Vice-President Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - Current Editor - European Journal of Pharmaceutical Sciences Elsevier BV, Netherlands
2017 - Current Member of Editorial Board - Journal of Controlled Release Elsevier BV, Netherlands
2010 - Current Expert Portuguese Evaluation Committed of Veterinary Drugs , Portugal
2008 - Current Research Associate Inovapotek Pharmaceutical Research and Development Lda, Portugal
2008 - 2016 Member of Scientific Council Instituto Universitário de Ciências da Saúde, Portugal
2002/03/01 - 2002/12/31 Farmacêutico Farmácia Falcao, Portugal

Others

Category
Host institution
Employer
2017/10/01 - Current Visiting Research Professor Queen's University Belfast, United Kingdom
2018/01 - 2022/01 Member of the Board of the Direction of the Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) Controlled Release Society, United States
2018/01 - 2019/09 Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society Controlled Release Society, United States
2014/06/30 - 2014/07/04 Erasmus Teaching Program Universitat de Barcelona, Spain
2013/06/17 - 2013/06/21 Erasmus Teaching Program Università degli Studi di Sassari, Italy
2012/12/01 - 2012/12/08 Mobility Teaching Program Universidade Estadual de Maringá, Brazil
2007/11/01 - 2012/10/31 Post Doc Researcher Universidade do Porto, Portugal
2012/06/13 - 2012/06/16 Erasmus Teaching Program Università degli Studi di Pavia, Italy
2010/06/01 - 2010/06/12 Erasmus Teaching Program Universitat de Barcelona, Spain
2008/01/10 - 2010/02/26 Post Doc Researcher Københavns Universitet, Denmark
2010/01/27 - 2010/02/19 Invited Researcher Northeastern University, United States
2004/01/01 - 2007/10/18 PhD Student Universidade do Porto, Portugal
2006/02/01 - 2006/08/18 Visiting PhD student Universidade de Santiago de Compostela, Spain
2005/05/01 - 2005/06/30 Visiting PhD Student Københavns Universitet, Denmark
2003/01/01 - 2003/12/31 Associate manager Associação Nacional das Farmácias, Portugal
Projects

Grant

Designation Funders
2021 - Current Glioblastoma Next Top Multi 3D Model for Anti-angiogenic Nanomedicines Efficacy Testing
2021_GBM_Multi3D_PI2RL_IINFACTS_2021
Supervisor
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2021 - 2026 Molecular Bioengineering in health ERA chair
Proposal 951723 MOBILIsE
Researcher
2021 - 2024 Firefighting occupational exposure and early effects on the health of operational forces
PCIF/SSO/0090/2019
Principal investigator

Contract

Designation Funders
2018 - Current Tissue engineered 3D models of gastric wall for permeability studies of drug-loaded nanoparticles
N/A
Supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Outputs

Publications

Book chapter
  1. Sarmento, Bruno. "In vitro assays for nanoparticle-cancer cell interaction studies". In Bio-Nanomedicine for Cancer Therapy. Springer, 2021.
    Accepted
  2. Sarmento, Bruno. "Implantable and long-lasting drug delivery systems for cancer treatment". In Long Acting Drug Delivery Systems. Elsevier, 2021.
    Accepted
  3. Sarmento, Bruno. "Targeted Photodynamic Immunotherapy". In Delivery Strategies and Engineering Technologies in Cancer Immunotherapy. 2021.
    Accepted
  4. Sarmento, Bruno. "3D intestinal models towards a more realistic permeability screening, in Nanotechnology for oral drug delivery: From concept to applications". In Nanotechnology for oral drug delivery: From concept to applications. Elsevier, 2020.
    Published
Conference poster
  1. Sarmento, Bruno. "Development of functionalized nanoparticles for the stabilization and repair of central nervous system myelin under assault by acquired demyelinating diseases". Paper presented in 3rd SPLC-CRS young scientists virtual meeting, 2021.
  2. Sarmento, Bruno. "Combinatory therapeutic strategy to metastatic colorectal cancer treatment using functionalized nanoparticles". Paper presented in United Kingdon-Ireland Controlled Release Society Symposium, 2020.
  3. Sarmento, Bruno. "Novel functional chitosan derivative improves intestinal permeability of camptothecin". Paper presented in United Kingdon-Ireland Controlled Release Society Symposium, 2020.
  4. Sarmento, Bruno. "Targeting polymeric conjugates with biologic responsive properties to manufacture docetaxel loaded nanoparticles for glioblastoma chemotherapy". Paper presented in United Kingdon-Ireland Controlled Release Society Symposium, 2020.
  5. Sarmento, Bruno. "Targeted cathelicidin nanomedicines as novel glucoregulator in diabetes therapy". Paper presented in United Kingdon-Ireland Controlled Release Society Symposium, 2020.
  6. Sarmento, Bruno. "Docetaxel nanomedicine based on biologic-responsive polymers for glioblastoma chemotherapy". Paper presented in American Chemical Society Spring National Meeting & Expo, 2020.
  7. Sarmento, Bruno. "Engineered albumin-functionalized nanoparticles for improved FcRn binding enhance oral delivery of insulin". Paper presented in 47th Controlled Release Society Annual Meeting, 2020.
  8. Sarmento, Bruno. "Novel Chitosan Polymeric Micelles as a Delivery Vehicle of Hydrophobic Anticancer Drugs". Paper presented in 47th Controlled Release Society Annual Meeting, 2020.
  9. Sarmento, Bruno. "Vaginal antiretroviral drug-loaded liposomes-in-fibers for preventing sexual HIV-1 transmission". Paper presented in 47th Controlled Release Society Annual Meeting, 2020.
  10. Sarmento, Bruno. "CEA-targeted nanoparticles to metastatic Colorectal Cancer treatment". Paper presented in 47th Controlled Release Society Annual Meeting, 2020.
  11. Sarmento, Bruno. "NanoIntelligent bioartificial pancreas for diabetes therapy". Paper presented in 47th Controlled Release Society Annual Meeting, 2020.
  12. Sarmento, Bruno. "Development of novel three-dimensional bioengineered biorelevent in vitro intestinal model to screen paracellular permeability". Paper presented in 47th Controlled Release Society Annual Meeting, 2020.
  13. Sarmento, Bruno. "Targeting tumor microenvironment to improve the chemotherapeutic treatment in metastatic Colorectal Cancer". Paper presented in EACR-AACR Basic & Translational Research Conference on Tumor Microenvironment, 2020.
  14. Sarmento, Bruno. "Antifungal peptides as potential alternatives for the management of vulvovaginal candidiasis". Paper presented in 17th Iberian Peptide Meeting, 2020.
  15. Sarmento, Bruno. "Bioengineered glucose-responsive nanoparticles in artificial pancreas for diabetes therapy". Paper presented in XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  16. Sarmento, Bruno. "Targeted cathelicidin nanomedicines as novel glucoregulator in diabetes therapy". Paper presented in XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  17. Sarmento, Bruno. "Combinatory therapeutic strategy to metastatic colorectal cancer treatment using functionalized CEA-targeted nanoparticles". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  18. Sarmento, Bruno. "Zein nanoparticles as potential oral carriers for resveratrol". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  19. Sarmento, Bruno. "Development of a new 3D intestinal model as a more reliable platform to perform in vitro drug permeability studies". Paper presented in XIIIth Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  20. Sarmento, Bruno. "A biophysical insight of camptothecin interaction with biomembrane models based in colloidal interfaces". Paper presented in 8th Iberian Meeting on Colloids and Interfaces, 2019.
Journal article
  1. Patrícia Batista; Pedro M. Castro; Ana Raquel Madureira; Bruno Sarmento; Manuela Pintado. "Preparation, Characterization and Evaluation of Guar Films Impregnated with Relaxing Peptide Loaded into Chitosan Microparticles". Applied Sciences (2021): https://www.mdpi.com/2076-3417/11/21/9849.
    10.3390/app11219849
  2. José Manoel Wanderley Duarte Neto; Jônatas de Carvalho Silva; Flávia Sousa; Odete Sofia Lopes Gonçalves; Maria Carolina de Albuquerque Wanderley; Bruno Sarmento; Carolina de Albuquerque Lima; Maria Teresa Neves-Petersen; Ana Lúcia Figueiredo Porto. "Structural and functional analysis of broad pH and thermal stable protease from Penicillium aurantiogriseum URM 4622". Preparative Biochemistry & Biotechnology (2021): https://doi.org/10.1080/10826068.2021.1972429.
    10.1080/10826068.2021.1972429
  3. Flávia Castro; Catarina Leite Pereira; Maria Helena Macedo; Andreia Almeida; Maria José Silveira; Sofia Dias; Ana Patrícia Cardoso; Maria José Oliveira; Bruno Sarmento. "Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening". Advanced Drug Delivery Reviews 175 (2021): 113824-113824. https://doi.org/10.1016/j.addr.2021.06.001.
    10.1016/j.addr.2021.06.001
  4. Sepehr Talebian; Tiago Rodrigues; José das Neves; Bruno Sarmento; Robert Langer; João Conde. "Facts and Figures on Materials Science and Nanotechnology Progress and Investment". ACS Nano (2021): https://doi.org/10.1021/acsnano.1c03992.
    10.1021/acsnano.1c03992
  5. Andreia Almeida; Eduarda Fernandes; Bruno Sarmento; Marlene Lúcio. "A Biophysical Insight of Camptothecin Biodistribution: Towards a Molecular Understanding of Its Pharmacokinetic Issues". Pharmaceutics 13 6 (2021): 869-869. https://doi.org/10.3390/pharmaceutics13060869.
    10.3390/pharmaceutics13060869
  6. Filipa A. L. S. Silva; Raquel Costa-Almeida; Licínia Timochenco; Sara I. Amaral; Soraia Pinto; Inês C. Gonçalves; José R. Fernandes; et al. "Graphene Oxide Topical Administration: Skin Permeability Studies". Materials (2021): https://doi.org/10.3390/ma14112810.
    10.3390/ma14112810
  7. Daniela Lopes-de-Campos; Catarina Pereira-Leite; Philippe Fontaine; Ana Coutinho; Manuel Prieto; Bruno Sarmento; Sven Jakobtorweihen; Cláudia Nunes; Salette Reis. "Interface-Mediated Mechanism of Action—The Root of the Cytoprotective Effect of Immediate-Release Omeprazole". Journal of Medicinal Chemistry (2021): https://doi.org/10.1021/acs.jmedchem.1c00251.
    10.1021/acs.jmedchem.1c00251
  8. Cláudia Azevedo; Soraia Pinto; Sopisa Benjakul; Jeannette Nilsen; Hélder A. Santos; Giovanni Traverso; Jan Terje Andersen; Bruno Sarmento. "Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery". Advanced Drug Delivery Reviews (2021): https://doi.org/10.1016/j.addr.2021.04.016.
    10.1016/j.addr.2021.04.016
  9. Andrade, Fernanda; Rafael, Diana; Vilar-Hernández, Mireia; Montero, Sara; Martínez-Trucharte, Francesc; Seras-Franzoso, Joaquin; Díaz-Riascos, Zamira V.; et al. "Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo". Journal of Controlled Release 331 (2021): 198-212. http://dx.doi.org/10.1016/j.jconrel.2021.01.022.
    10.1016/j.jconrel.2021.01.022
  10. William Marcondes Facchinatto; Joana Galante; Letícia Mesquita; Daniella Souza Silva; Danilo Martins dos Santos; Tiago Bueno Moraes; Sérgio Paulo Campana-Filho; et al. "Clotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis". Acta Biomaterialia (2021): https://doi.org/10.1016/j.actbio.2021.02.029.
    10.1016/j.actbio.2021.02.029
  11. Ana C. Henriques; Patrícia M. A. Silva; Bruno Sarmento; Hassan Bousbaa. "The Mad2-Binding Protein p31comet as a potential target for human cancer therapy". Current Cancer Drug Targets (2021): https://doi.org/10.2174/1568009621666210129095726.
    10.2174/1568009621666210129095726
  12. Fernando Notario-Pérez; Raúl Cazorla-Luna; Araceli Martín-Illana; Joana Galante; Roberto Ruiz-Caro; Bruno Sarmento; José das Neves; María-Dolores Veiga. "Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of Hydroxypropyl Methylcellulose/Zein Vaginal Anti-HIV Films Containing Tenofovir". Biomacromolecules (2021): https://doi.org/10.1021/acs.biomac.0c01609.
    10.1021/acs.biomac.0c01609
  13. Vasconcelos, Teófilo; Prezotti, Fabíola; Araújo, Francisca; Lopes, Carlos; Loureiro, Ana; Marques, Sara; Sarmento, Bruno. "Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol". International Journal of Pharmaceutics (2021): 120245. http://dx.doi.org/10.1016/j.ijpharm.2021.120245.
    10.1016/j.ijpharm.2021.120245
  14. Wang, Zhen; Kapadia, Wasim; Li, Cuidi; Lin, Feng; Pereira, Ruben F.; Granja, Pedro L.; Sarmento, Bruno; Cui, Wenguo. "Tissue-specific engineering: 3D bioprinting in regenerative medicine". Journal of Controlled Release 329 (2021): 237-256. http://dx.doi.org/10.1016/j.jconrel.2020.11.044.
    10.1016/j.jconrel.2020.11.044
  15. Sarmento, Bruno. "Quercetin-biapigenin nanoparticles are effective to penetrate the blood-brain barrie". Drug Delivery and Translational Research (2021):
    In press
  16. Sarmento, Bruno. "A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin". Drug Delivery and Translational Research (2021):
    In press
  17. Sarmento, Bruno. "Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments". Advanced Drug Delivery Reviews (2021):
    In press
  18. Sarmento, Bruno. "An overview on the role of the Mad2-binding protein p31comet in mitotic exit and human cancer". Current Cancer Drug Targets (2021):
    In press
  19. Sarmento, Bruno. "The effect of hypergravity in intestinal permeability of nanoformulations and molecules". European Journal of Pharmaceuticals and Biopharmaceuticals (2021):
    In press
  20. Sarmento, Bruno. "The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs". European Journal of Pharmaceuticals and Biopharmaceuticals (2021):
    In press
  21. Sarmento, Bruno. "Advances on Colorectal Cancer 3D models: the needed translational technology for nanomedicine screening". Advanced Drug Delivery Reviews (2021):
    In press
  22. Sarmento, Bruno. "Immunomodulatory nanomedicine for colorectal cancer treatment: a landscape to be explored?". Biomaterials Science (2021):
    In press
  23. Maria José Silveira; Flávia Castro; Maria José Oliveira; Bruno Sarmento. "Immunomodulatory nanomedicine for colorectal cancer treatment: a landscape to be explored?". Biomaterials Science (2021): https://doi.org/10.1039/D1BM00137J.
    10.1039/D1BM00137J
  24. Sara Silva; Cláudia Alves; Diana Duarte; Ana Costa; Bruno Sarmento; António J. Almeida; Paula Gomes; Nuno Vale. "Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity". International Journal of Molecular Sciences 22 1 (2020): 242-242. https://doi.org/10.3390/ijms22010242.
    10.3390/ijms22010242
  25. Notario-Pérez, Fernando; Galante, Joana; Martín-Illana, Araceli; Cazorla-Luna, Raúl; Sarmento, Bruno; Ruiz-Caro, Roberto; das Neves, José; Veiga, María-Dolores. "Development of pH-sensitive vaginal films based on methacrylate copolymers for topical HIV-1 pre-exposure prophylaxis". Acta Biomaterialia (2020): http://dx.doi.org/10.1016/j.actbio.2020.12.019.
    10.1016/j.actbio.2020.12.019
  26. Cristelo, Cecília; Machado, Alexandra; Sarmento, Bruno; Gama, Francisco Miguel. "The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility". Endocrine Connections (2020): http://dx.doi.org/10.1530/ec-20-0484.
    10.1530/ec-20-0484
  27. Formiga, Fabio Rocha; Sarmento, Bruno. "Emerging trends in nano- and microencapsulation science: hallmarks of the 22nd International Symposium on Microencapsulation". Drug Delivery and Translational Research 10 6 (2020): 1535-1536. http://dx.doi.org/10.1007/s13346-020-00865-7.
    10.1007/s13346-020-00865-7
  28. Cláudia Martins; Veeren M Chauhan; Marco Araújo; Amjad Abouselo; Cristina C Barrias; Jonathan W Aylott; Bruno Sarmento. "Advanced polymeric nanotechnology to augment therapeutic delivery and disease diagnosis". Nanomedicine (2020): https://doi.org/10.2217/nnm-2020-0145.
    10.2217/nnm-2020-0145
  29. Sílvia A. Moreira; Sara Silva; Eduardo Costa; Soraia Pinto; Bruno Sarmento; Jorge A. Saraiva; Manuela Pintado. "Effect of High Hydrostatic Pressure Extraction on Biological Activities and Phenolics Composition of Winter Savory Leaf Extracts". Antioxidants 9 9 (2020): 841-841. https://doi.org/10.3390/antiox9090841.
    10.3390/antiox9090841
  30. Alexandre C.C. Vieira; Luíse L. Chaves; Marina Pinheiro; Sofia Costa Lima; Pedro José Rolim Neto; Domingos Ferreira; Bruno Sarmento; Salette Reis. "Lipid nanoparticles coated with chitosan using a one-step association method to target rifampicin to alveolar macrophages". Carbohydrate Polymers (2020): https://doi.org/10.1016/j.carbpol.2020.116978.
    10.1016/j.carbpol.2020.116978
  31. Barros, Andreia Sofia; Costa, Ana; Sarmento, Bruno. "Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs". Advanced Drug Delivery Reviews (2020): http://dx.doi.org/10.1016/j.addr.2020.09.008.
    10.1016/j.addr.2020.09.008
  32. Abdolelah Jaradat; Maria Helena Macedo; Flávia Sousa; Kenton Arkill; Cameron Alexander; Jonathan Aylott; Bruno Sarmento. "Prediction of the enhanced insulin absorption across a triple co-cultured intestinal model using mucus penetrating PLGA nanoparticles". International Journal of Pharmaceutics 585 (2020): 119516-119516. https://doi.org/10.1016/j.ijpharm.2020.119516.
    10.1016/j.ijpharm.2020.119516
  33. Ana Baião; Flávia Sousa; Ana Vanessa Oliveira; Carla Oliveira; Bruno Sarmento. "Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting the CD44v6 receptor in colon cancer cells". Biomaterials Science (2020): https://doi.org/10.1039/D0BM00556H.
    10.1039/D0BM00556H
  34. Antti Rahikkala; Flavia Fontana; Tomás Bauleth-Ramos; Alexandra Correia; Marianna Kemell; Jani Seitsonen; Ermei Mäkilä; et al. "Hybrid red blood cell membrane coated porous silicon nanoparticles functionalized with cancer antigen induce depletion of T cells". RSC Advances (2020): https://doi.org/10.1039/D0RA05900E.
    10.1039/D0RA05900E

Other

Other output
  1. Leandro Gabriel; Helena Almeida; Marta Avelar; Bruno Sarmento; José das Neves. 2021. MPTHub: an open-source software for characterizing the transport of particles in biorelevant media. https://doi.org/10.1101/2021.09.15.460434.
    10.1101/2021.09.15.460434
  2. Andreia Almeida; Eduarda Fernandes; Bruno Sarmento; Marlene Lúcio. 2021. A Biophysical Insight of Camptothecin Biodistribution: Towards a Molecular Understanding of Its Pharmacokinetic Issues. https://doi.org/10.20944/preprints202105.0480.v1.
    10.20944/preprints202105.0480.v1
  3. Filipa A. L. S. Silva; Raquel Costa-Almeida; Licínia Timochenco; Sara I. Amaral; Soraia Pinto; Inês C. Gonçalves; José R. Fernandes; et al. 2021. Graphene Oxide Topical Administration: Skin Permeability Studies. https://doi.org/10.20944/preprints202103.0550.v1.
    10.20944/preprints202103.0550.v1
  4. Rute Nunes; Sarah Bogas; Maria João Faria; Hugo Gonçalves; Marlene Lúcio; Teresa Viseu; Bruno Sarmento; José das Neves. 2021. Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate and emtricitabine in the context of topical pre-exposure prophylaxis. https://doi.org/10.1101/2021.02.01.429162.
    10.1101/2021.02.01.429162
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021 Surface modification of nanoparticles to allow improved oral absorption of anti-diabetic peptides via FcRn FcRn-targeted therapies for Aitoimmune Disorders (Online=
2021 Bioengineered CD44v6-targeted nanomedicines for anticancer drug delivery 25th Anniversary meeting of the CRS Germany Chapter (Online)
2020 Combining mucodiffusion and epithelial transcytosis of nanoparticles to provide efficient absorption of anti-diabetic peptides Nanomed-Argentina
(Argentina)
2020 Receptor-mediated transport of functionalized mucodiffusive nanoparticles for enhancing intestinal absorption of anti-diabetic peptides, New Horizons of Nanobiological Therapeutics The 43rd Korean Academy of Science and Technology International Symposium (Online Conference)
2020 Functionalized nanomedicines to oral delivery of anti-diabetic peptides Drug Delivery and Precision Medicine, National University of Singapore (Online Conference)
2020 Molecular bioengineered nanomedicines for targeted delivery of peptides in modulation of diabetes 12th European and Global Summit for Nanomedicine – CLINAM 2020 (Online Conference)
2020 Synthesis of biologic-responsive polymers for the manufacturing of docetaxel-loaded nanoparticles for glioblastoma chemotherapy 1st Discoveries Forum on Regenerative and Precision Medicine
2020 Synthesis of biologic-responsive targeting polymeric conjugates to manufacture docetaxel-loaded nanoparticles for glioblastoma chemotherapy XIII Spanish-Portuguese Conference on Controlled Drug Delivery
2020 Polymeric micelles obtained by a novel chitosan derivative as potential delivery nanosystem of hydrophobic drugs XIII Spanish-Portuguese Conference on Controlled Drug Delivery
2020 Towards the synthesis of biologic-responsive targeting polymeric conjugates to manufacture docetaxel-loaded nanoparticles for glioblastoma chemotherapy Controlled Release Society Annual Meeting - Online
2020 Novel three-dimensional multilayer bioengineered in vitro model to perform reliable epithelial-endothelial permeability studies I Congresso (Virtual) Brasileiro de Engenharia de Tecidos
2020 Development of a novel three-dimensional bioengineered biorelevant in vitro intestinal model to screen paracellular permeability
2019 Oral peptide delivery – Improving bioavailability through formulations Australian-New Zealand Controlled Release Society Joint Workshop, Dunedin
(New Zealand)
2019 Functionalized nanomedicines for intestinal delivery of anti-diabetic peptides Drug Delivery Australia 2019
(Australia)
2019 Functionalized nanomedicines for the disruptive intestinal delivery of anti-diabetic peptides 12th International Congress of Pharmaceutical Sciences (CIFARP)
2019 Biofunctionality and bioengineered poly(lactic-co-glycolic) acid in biomedicine XV Brazilian Polymers Congress
2019 Functionalized PLGA nanomedicines for the disruptive delivery of biopharmaceutical drugs 22th International Symposium on Microencapsulation
2019 Synthesis of biologic-responsive polymers for the manufacturing of docetaxel-loaded nanoparticles for glioblastoma chemotherapy 1st Nano2Clinic COST Action CA17140 Conference
2019 Multifunctional stimuli-responsive pancreas mimetic New frontiers in biofabrication: From biomolecules to tissues and organs
2019 3D bioengineered small intestine for drug absorption studies New frontiers in biofabrication: From biomolecules to tissues and organs
2019 Amphiphilic chitosan derivatives as potential delivery vehicle of hydrophobic anticancer drugs New frontiers in biofabrication: From biomolecules to tissues and organs

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2020 - Current glycoINSPIRER: A multivalente glycocode-inpired nanovaccine for bladder cancer immunotherapy
Co-supervisor
Biomedical Sciences (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020 - Current Development of a bioengineered pancreas using iPSCs to treat type 1 diabetes
Supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - Current Oral delivery of semaglutide through multifunctional FcRn-peptide targeting nanoparticles for treatment of type 2 diabetes mellitus
Supervisor
Biomedical Sciences (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - Current Development of targeted nanomedicines for the stabilization and repair of central nervous system myelin under assault by acquired demyelinating diseases
Supervisor
Biomedical Sciences (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - Current Nanomedicine as a tool to surpass bioavailability constraints: development of polymeric nanoparticles smart carriers for single or combined drug delivery
Co-supervisor
Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2019 - Current Multifunctional natural derived peptide extracts for skin care
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - Current Construction of a multivalent glycan-based nanovaccine for bladder cancer: A step towards effective immunotherapies
Co-supervisor
2019 - Current Vaginal rings for sustained release of nanoparticles containing antimicrobial peptides: A new strategy for managing recurrent vulvovaginal candidiasis
Co-supervisor
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - Current Cell penetrating p28 peptide-mediated delivery of nanomedicines for cancer treatment
Supervisor
Junior Researcher (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2021 - 2021 2021 Controlled Release Society Annual Meeting (Online), Montreal, Canada, 2021 (2021 - 2021)
Conference (Member of the Organising Committee)
Controlled Release Society, United States
2021 - 2021 31st Conference of the European Society of Biomaterials, Porto, Portugal (2021 - 2021)
Congress

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2020 Dual-purpose oromucosal films and tablets for the local management of oral mucositis
(Thesis) Arguer
João Costa Campos (PhD)
Universidade do Porto, Portugal
2020 Bacterial cellulose wound dressing
(Thesis) Arguer
Ana Cristina da Costa Rodrigues (PhD)
Universidade do Minho, Portugal
2020 Evaluation of high-pressure as a novel non-thermal extraction technology to obtain extracts with improved biological activities
(Thesis) Arguer
Sílvia Alexandra Monteiro Moreira (PhD)
Universidade de Aveiro, Portugal
2020 Theranostic Nanocomposites for Cancer Immunotherapy
(Thesis) Arguer
Tomás Bauleth Quinta Ferreira Ramos (PhD)
Universidade do Porto, Portugal
2020 Characterization of nutritional and healthy properties of local Tuscany varieties and evaluation of innovative nanosystems for the delivery of their nutraceutical components to the human body
(Thesis) Arguer
Denise Benconcini (PhD)
Università degli Studi di Siena, Italy
2019 Production and characterization of electrospun membranes for wound dressing applications
(Thesis) Arguer
Sónia Alexandra Pereira Miguel (PhD)
2019 Bioinspired three-dimensional multifunctional systems to enhance the therapeutic potential of mesenchymal stromal cells
(Thesis) Arguer
Ainhoa Gonzalez Pujana (PhD)
2019 Libertação controlada de bioativos suportados por nanoparticulas de pseudoboemita obtidas pelo processo sol-gel
(Thesis) Arguer
Isabella Tereza Ferro Barbosa (PhD)
2019 Development of antihelmintic and antibiotic microneedle delivery systems for treatment of lymphatic filariasis
(Thesis) Arguer
Andi Dian Permana (PhD)

Association member

Society Organization name Role
2008 - Current Controlled Release Society
2008 - Current American Association of Pharmaceutical Scientists
2008 - Current International Pharmaceutical Federation
Distinctions

Award

2021 Colleague of Fellows
Controlled Release Society, United States
2020 European Space Agency - SpinYourThesis
European Space Agency, France