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I graduated with a degree in Biomedical Engineering in September 2020 from Instituto Superior de Engenharia do Porto and completed my Master’s in Biomedical Engineering in September 2022 at the Faculty of Engineering, University of Porto (UP). Since then, I have been working as a research fellow in the field of chronic kidney disease (CKD), focusing on the identification of novel biomarkers and therapeutic targets to improve clinical outcomes and patient management. Within this research domain, I have been a key contributor to the project “Peroxidasin as a Novel Target in Chronic Kidney Disease Diagnosis and Treatment”, funded by FCT (ref: 2022.04524.PTDC). My work in this project has resulted in several significant outputs: I am the first author of a research article currently under revision (“Characterization of peroxidasin expression in histologically normal human adult and fetal kidney tissue”, DOI: 10.1101/2023.12.21.572848), the author of a short communication (“Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma”, DOI: 10.1101/2024.11.15.623667), and first co-author of a conference abstract published in the Nephrology Dialysis and Transplantation (NDT) journal (“Altered peroxidasin expression pattern in IgA Nephropathy”, DOI: 10.1093/ndt/gfae069.290). I have also been the first and presenting author of three oral communications, including presentations at IJUP 2022 (Porto, Portugal), the 61st ERA Congress (“Altered peroxidasin expression pattern in IgA Nephropathy”, Stockholm, Sweden, 2024), and the 62nd ERA Congress ("Peroxidasin expression in Alport Syndrome associates with histological kidney tissue damage", Vienna, Austria, 2025). In addition, I have contributed to six other oral presentations at national and international meetings, such as Encontro Renal – Sociedade Portuguesa de Nefrologia (SPN) (2021, 2022), IJUP 2023, the 35th European Congress of Pathology (Dublin, 2023), and the 21st European Congress on Digital Pathology (Barcelona, 2025). Driven by a strong collaborative spirit and eagerness to learn, I have actively contributed to several other studies as patent by being an author of an article on microRNA expression in CKD (currently under review, BioRxiv, DOI: 10.1101/2024.10.10.617547), another conference abstract in NDT (DOI: 10.1093/ndt/gfae069.485), and five additional oral communications presented at IJUP 2023, Encontro Renal- SPN 2023 (Porto), and both the 61st and 62nd ERA Congresses (Stockholm and Vienna). I have received two best abstract awards, one in basic nephrology and the other in clinical nephrology (SPN, 2023). Furthermore, I am involved in establishing two patient cohorts for CKD research, approved by the Ethics Committee of Unidade Local de Saúde de São João (Porto, Portugal). These cohorts have been instrumental in advancing our group’s research goals and fostering new collaborations, including with a recently funded FCT project (DecodAge, 2024). Since 2022, I have also served as a tutor for undergraduate medical students, introducing them to key laboratory techniques and the workflow of a translational research environment. Beyond the lab, I am actively engaged in science communication. I am a member of the cienciaetal initiative at i3S and have represented i3S at the Mostra UP science fair in 2022 and 2023. In January 2024, I enrolled in the Doctoral Program in Biomedical Sciences at Instituto de Ciências Biomédicas Abel Salazar (UP), with the goal of pursuing a research career. I am deeply committed to translating research findings into meaningful clinical advancements for patients with kidney disease and to contributing to the scientific community through impactful research.
Identification

Personal identification

Full name
Isabel Maria Carvalho Brandão

Citation names

  • Brandão, Isabel

Author identifiers

Ciência ID
E71C-F978-BA1A
ORCID iD
0009-0008-7536-3726

Email addresses

  • ibrandao@i3s.up.pt (Professional)
  • isabelmariacarvalhobrandao@gmail.com (Personal)

Telephones

Mobile phone
  • (+351) 911110472 (Personal)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Medical and Health Sciences - Clinical Medicine - Urology and Nephrology
  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Exact Sciences - Mathematics
  • Engineering and Technology - Industrial Biotechnology - Bioproducts Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1) Advanced (C1)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2024/01 - 2027/12
Ongoing
Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/14 - 2023/05/27
Concluded
Formação Avançada em Tratamento Estatístico de Dados (Outros)
Universidade Católica Portuguesa Instituto de Ciências da Saúde, Portugal
18
2020/10 - 2022/09/30
Concluded
Engenharia Biomédica (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
"Peroxidasin as a possible new therapeutic target in kidney fibrosis" (THESIS/DISSERTATION)
17
2017/09 - 2020/09
Concluded
Engenharia Biomédica (Licenciatura)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
14
Projects

Grant

Designation Funders
2023/03/16 - 2025/12/31 Peroxidasin as a Novel Target in Chronic Kidney Disease Diagnosis and Treatment
2022.04524.PTDC
Research Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
Outputs

Publications

Conference abstract
  1. Brandão, Isabel; Silva, Roberto; Conde-Sousa, Eduardo; Gomes, Bárbara; Marti, Hans-Peter; Chen, Tony; Faria, Bernardo; et al. "Altered peroxidasin expression pattern in IgA Nephropathy". Paper presented in 61st ERA Congress, Stockholm, 2024.
    Published
  2. Ramil-Gómez Olalla; Carvalho, Eduarda; Cerqueira, Ana; Paulo, Núria; Santos, Janete; Moura, Sara; Brandão, Isabel; et al. "Pinpointing specific circulating microRNAs as putative biomarkers for chronic kidney disease and cardiovascular outcomes". Paper presented in 61st ERA Congress, Stockholm, 2024.
    Published
Preprint
  1. Ramil-Gómez Olalla; Cerqueira, Ana; Moura, Sara Reis; Carvalho, Eduarda; Paulo, Núria; Brandão, Isabel; Santos, Janete; et al. "Circulating microRNAs as biomarkers of chronic kidney disease and its association with renal and cardiovascular outcomes in non-dialysis patients". 2024. https://www.biorxiv.org/content/10.1101/2024.10.10.617547v1.full.
  2. Silva, Roberto; Almeida, Jorge Reis; Coelho, Ana Rita; Brandão, Isabel; Gomes, Bárbara; Alencastre, Inês Soares; Oliveira, João Paulo. "Peroxidasin expression is increased in intratumoural capillaries and in proximal tubular cells adjacent to clear cell renal cell carcinoma". 2024. https://doi.org/10.1101/2024.11.15.623667.
    10.1101/2024.11.15.623667
  3. Brandão, Isabel; Silva, Roberto; Conde, Eduardo; Gomes, Bárbara; Sampaio, Paula; Braga, Ana Costa; Almeida, Jorge Reis; Soares Alencastre, Inês; Paulo Oliveira, João. "Characterization of peroxidasin expression in histologically normal human adult and fetal kidney tissue". 2023. http://dx.doi.org/10.1101/2023.12.21.572848.
    10.1101/2023.12.21.572848
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/06/25 Automated Segmentation of Unstained Kidney Biopsies: The Feasibility and Challenges 21st European Congress on Digital Pathology 2025
European Society of Digital and Integrative Pathology (Spain)
2025/06/05 Peroxidasin expression in Alport Syndrome associates with histological kidney tissue damage. 62nd ERA congress
European Renal Association (Viena, Austria)
2025/06/05 Predicting disease progression in IgA Nephropathy Portuguese patients: the role of inflammation and vascular damage markers beyond the IgAN PT. 62nd ERA congress
European Renal Association (Viena, Austria)
2024/05/23 Altered peroxidasin expression pattern in IgA nephropathy 61st ERA Congress
European Renal Association (Stockholm, Sweden)
2024/05/23 Pinpointing specific circulating microRNAs as putative biomarkers for chronic kidney disease and cardiovascular outcomes 61st ERA Congress
European Renal Association (Stockholm, Sweden)
2023/11 Identification of circulating miRNAs enrolled in chronic kidney disease progression and cardiovascular outcomes Encontro Renal de 2023 - XXXVII Congresso da Sociedade Portuguesa de Nefrologia
Sociedade Portuguesa de Nefrologia (Porto, Portugal)
2023/11 A series of electron microscopy kidney biopsies and the frequency of ultrastructural findings indistinguishable from Alport's disease/collagen IV in the glomerular basement membrane, without an established genetic diagnosis in northern Portugal Encontro Renal de 2023 - XXXVII Congresso da Sociedade Portuguesa de Nefrologia
Sociedade Portuguesa de Nefrologia (Porto, Portugal)
2023/09 Peroxidasin is overexpressed in intratumoral vessels and in adjacent proximal tubular cells in renal cell tumours 35th European Congress of Pathology
European Society of Pathology (Dublin, Ireland)
2023/05 MicroRNAs in Kidney-Heart Fibrosis IJUP 2023
Universidade do Porto (Porto, Portugal)
2023/05 Evaluation of a new player in renal fibroblast activation IJUP 2023
Universidade do Porto (Porto, Portugal)
2022/11/19 Analysis of peroxidasin expression in IgA nephropathy: association with renal fibrosis and disease progression Encontro Renal de 2022 - XXXVI Congresso da Sociedade Portuguesa de Nefrologia
Sociedade Portuguesa de Nefrologia (Quarteira, Portugal)
2022/05 Identification of a Possible New Therapeutic Target in Kidney Fibrosis IJUP'22 - 15º Encontro de Investigação Jovem da Universidade do Porto
Universidade do Porto (Porto, Portugal)
2021/10/14 Analysis of Peroxidasin Expression in IgA Nephropathy: Association with Renal Fibrosis and Disease Progression Encontro Renal de 2021 - XXXV Congresso da Sociedade Portuguesa de Nefrologia
Sociedade Portuguesa de Nefrologia (Vilamoura, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/04/16 - 2024/04/16 As part of the educational program of i3S - Ciência et al/Escolas i3S- I perform the specific function of collaborating and carrying out, along with the rest of the team of researchers and colaborators, the workshop "Herança do's Maias" with students in the 11th/12th year of secondary school. (2024)
Workshop (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/04/21 - 2022/04/24 "Mostra da Universidade do Porto 2022": Promotion of the Institute for Research and Innovation in Health (i3s) stand. (2022/04/21 - 2022/04/24)
Exhibition (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/11/14 - 2024/11/15 Scientific annual meeting of i3S
Conference
11th i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/10/03 - 2024/10/04 Taking place at i3S on the 3rd and 4th of October 2024, the 7th PhDay celebrates the symbiotic relationship between theoretical and applied research, recognizing that both are essential pillars of scientific progress.
Symposium
7th PhDay: From Theory to Application: Research in Action
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/05/27 - 2024/05/29 This course intends to give a brief introduction (Theoretical & Practical) to the use of QuPath (free open-source software for "Quantitative Pathology") for analysis of tile & stitched large image datasets, such as those obtained at slide scanners from the Histopathology and Bioimaging Units.
Workshop
Introduction to QuPath - 3rd Edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2024/05/23 - 2024/05/26 European renal scientific congress promoted by the European Renal Association.
Congress
61st ERA Congress
European Renal Association European Dialysis and Transplant Association, Italy
2024/05/13 - 2024/05/13 Seminar that aimed to teach researchers how to communicate science to policymakers.
Seminar
Communicating Science in Politics Seminar
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/11/16 - 2023/11/17 Scientific annual meeting of i3S
Meeting
10th i3S Annual Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Mentoring / Tutoring

Topic Student name
2025/01/08 - 2025/01/22 Tutoring of immunohistochemistry technique, image acquisition and analysis to medical undergraduate Jehimy Alvarez
2024/03/24 - 2024/04/15 Tutoring of immunohistochemistry technique, image acquisition and analysis to medical undergraduate José Esteves
2022/08 - 2022/08 Tutoring of immunohistochemistry technique to medical undergraduates Marco António Gonçalves Meleiro; Rafaela Fernandes Alves.
Distinctions

Award

2023 Best Abstract in Basic Nephrology - Identification of circulating miRNAs enrolled in chronic kidney disease progression and cardiovascular outcomes
Sociedade Portuguesa de Nefrologia, Portugal
2023 Best Abstract in Clinical Nephrology - A series of electron microscopy kidney biopsies and the frequency of ultrastructural findings indistinguishable from Alport's disease/collagen IV in the glomerular basement membrane, without an established genetic di
Sociedade Portuguesa de Nefrologia, Portugal