Cristina Maria Ferreira Almeida (E716-BA44-C4D1)

Curriculum Vitae

Cristina Maria Ferreira Almeida

Cristina Maria Ferreira Almeida completed her Bachelor in Biochemistry in 2017/07 by Faculdade de Ciências and Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto. In 2019/12, Cristina completed her Master in Biochemistry in the same institutions. Cristina started her PhD in Pharmaceutical Sciences, Biochemistry specialty, in 2021, at the Faculdade de Farmácia da Universidade do Porto. Until now, she published two review articles and three original research articles as first author. Additionally, she is also co-author of other five papers. Furthermore, Cristina published 6 abstracts in international indexed journals, presented 7 oral communications and 12 poster communications at international and national scientific meetings, participated in 4 workshops and was member of the organizing committee of a scientific meeting. Moreover, Cristina received an award for Best Oral Communication in Health Sciences in 2019. She participated as BSc Student Fellow in 1 project and has participated as mentor at Junior University event, from Universidade do Porto. In 2021, Cristina was awarded with a Liga Portuguesa Contra o Cancro - Núcleo Regional do Norte grant. Cristina works in the area of Natural and Biological Sciences with emphasis on Biochemistry and Cell Biology and also in the area of Medical and Health Sciences with emphasis in Clinical Medicine and Oncology. In her curriculum Ciência Vitae the most frequent terms in the context of scientific output are: Estrogen receptor-positive breast cancer, Aromatase; Estrogen receptors; Aromatase inhibitors; Anti-estrogens; Endocrine therapy; Endocrine resistance; Cannabinoids; Multi-target compounds and Virtual screening.

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Identification

Personal identification

Full name: Cristina Maria Ferreira Almeida
Date of birth: 1996/06/11
Gender: Female

Citation names

Almeida, Cristina
Almeida, Cristina F.
Cristina Almeida

Author identifiers

Ciência ID: E716-BA44-C4D1
ORCID iD: 0000-0003-2936-5620

Email addresses

cristina-almeida96@hotmail.com (Professional)
cmfalmeida11@gmail.com (Professional)

Telephones

Mobile phone

(+351) 913811871 (Personal)

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry
Natural sciences - Biological Sciences - Cell Biology
Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2021/02 - 2025/02 Ongoing	Doutoramento em Ciências Farmacêuticas (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal "Unveiling the anti-cancer potential and the clinical benefit of cannabinoids as an adjuvant therapy on estrogen receptor-positive (ER+) breast cancer" (THESIS/DISSERTATION)
2017/10 - 2019/12 Concluded	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Non-steroidal aromatase inhibitors for hormone-dependent breast cancer: virtual screening and in vitro effects" (THESIS/DISSERTATION)	18
2014/09 - 2017/07 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "The effects of cannabinoids in exemestane-resistant breast cancer cells" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2021/03/25 - Current	Researcher (Research)	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal (...)
2021/01/01 - 2021/06/30	Researcher (Research)	Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal (...)
2019/10/01 - 2020/06/30	Researcher (Research)	Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal (...)

Others

	Category Host institution	Employer
2019/07 - 2019/07	Junior University mentor	Universidade do Porto, Portugal
	Universidade do Porto, Portugal
2018/07 - 2018/07	Junior University mentor	Universidade do Porto, Portugal
	Universidade do Porto, Portugal

Projects

Contract

	Designation	Funders
2020/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDB/04378/2020 10.54499/UIDB/04378/2020 PhD Student Fellow Universidade NOVA de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDP/04378/2020 10.54499/UIDP/04378/2020 PhD Student Fellow Universidade NOVA de Lisboa, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/10/01 - 2020/06/30	Evaluation of crotoxin antitumoral activity in breast cancer: apoptosis, autophagy and oxidative stress 2017/25532-6 Research Fellow Universidade do Porto Faculdade de Farmácia, Portugal Universidade de São Paulo Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Brazil	Universidade de São Paulo Ongoing
2019/10/01 - 2020/06/30	Unidade de Ciências Biomoleculares Aplicadas UID/Multi/04378/2019 Research Fellow REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal Universidade do Porto Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference paper	Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. "Benefits of cannabidiol as an anti-breast cancer agent when combined with Exemestane". Paper presented in EACR 2023: Innovative Cancer Science, Turin, 2023. Published • 10.1002/1878-0261.13471 Almeida, Cristina F.; Augusto, Tiago V.; Oliveira, Ana; Correia-da-Silva, Georgina; Ramos, Maria João; Fernandes, Pedro Alexandrino; Teixeira, Natércia; Amaral, Cristina. "Tamoxifen bisphenol: a modulator of ERß in estrogen receptor-positive breast cancer". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020. Published • 10.3390/ECMC2020-07437 Amaral, Cristina; Trouille, Fabien; Almeida, Cristina F.; Correia-da-Silva, Georgina; Teixeira, Natércia. "Unveiling the Mechanisms Behind Cannabinoids as Potential Adjuvant Therapy for ER+ Breast Cancer". Paper presented in Medical Cannabis and Cannabinoids, Lisboa, 2020. Published • 10.1159/000505827 Almeida, Cristina; Oliveira, Ana; Fernandes, Pedro Alexandrino; Correia-da-Silva, Georgina; Ramos, Maria João; Augusto, Tiago V.; Teixeira, Natércia; Amaral, Cristina. "A novel approach for ER+ breast cancer treatment: A new compound that modulates aromatase and ER". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019. Published • 10.3390/ecmc2019-06337 Cristina F. Almeida; Augusto, Tiago V.; Correia-da-Silva, Georgina; Oliveira, Ana; Fernandes, Pedro Alexandrino; Ramos, Maria João; Cunha, Sara; Teixeira, Natércia. "Discovery of a multi-target compound for ER+ breast cancer: characterization of its biological effects". Paper presented in 14th YES - Young European Scientist - Meeting, Porto, 2019. Published • 10.1097/j.pbj.0000000000000054 Almeida, Cristina; Augusto, Tiago; Correia-da-Silva, Georgina; Teixeira, Natércia; Amaral, Cristina. "The effects of cannabinoids in exemestane-resistant breast cancer cells". Paper presented in 12th YES - Young European Scientist – Meeting, 2017. Published • 10.1016/j.pbj.2017.07.109
Conference poster	Amaral, Cristina; Augusto, Tiago; Almeida, Cristina F.; Valente, Maria João; Vinggaard, Anne Marie; Correia-da-Silva, Georgina; Teixeira, Natércia. "The role of ER, AR and tumor microenvironment for the aromatase inhibitors (AIs) used in breast cancer treatment". Paper presented in III ASPIC-ASEICA International Meeting, Cancer Immunology, Tumor Microenvironment & Metastasis, 2023. Almeida, Cristina F.; Teixeira, Natércia; Valente, Maria João; Vinggaard, Anne Marie; Correia-da-Silva, Georgina; Amaral, Cristina. "Cannabinoids and ERa: how hormones can affect their relation in breast cancer?". Paper presented in III ASPIC-ASEICA International Meeting, Cancer Immunology, Tumor Microenvironment & Metastasis, 2023. Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. "Benefits of cannabidiol as an anti-breast cancer agent when combined with Exemestane". Paper presented in EACR 2023: Innovative Cancer Science, 2023. Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. "The influence of tumor microenvironment on the effects induced by cannabidiol when combined with exemestane in estrogen receptor-positive breast tumors". Paper presented in Champalimaud Research Symposium, Tumor microenvironment – from cancer initiation to metastasis, 2022. Cristina F. Almeida; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. "Cannabidiol plus Exemestane in hormone-dependent breast tumors: effects on sensitive and resistant cells". Paper presented in 5th ASPIC International Congress, 2022. Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. "The potential benefit of combining cannabidiol with aromatase inhibitors in sensitive and resistant breast cancer cells". Paper presented in ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer, 2021. Almeida, Cristina F.; Amaral, Cristina; Torqueti, Maria Regina; Augusto, Tiago V.; Correia-da-Silva, Georgina; Teixeira, Natércia. "Mechanism of action of crotoxin in estrogen receptor-positive breast cancer". Paper presented in 27th Porto Cancer Meeting, 2021. Amaral, Cristina; Trouille, Fabien; Almeida, Cristina F.; Correia-da-Silva, Georgina; Teixeira, Natércia. "Unveiling the Mechanisms Behind Cannabinoids as Potential Adjuvant Therapy for ER+ Breast Cancer". Paper presented in CannX: The International Medical Cannabis Conference, 2020. Almeida, Cristina F.; Augusto, Tiago V.; Correia-da-Silva, Georgina; Oliveira, Ana; Fernandes, Pedro Alexandrino; Ramos, Maria João; Cunha, Sara; Teixeira, Natércia; Amaral, Cristina. "Discovery of a multi-target compound for ER+ breast cancer: characterization of its biological effects". Paper presented in 14th YES - Young European Scientist - Meeting, 2019. Almeida, Cristina F.; Oliveira, Ana; Amaral, Cristina; Ramos, Maria João; Correia-da-Silva, Georgina; Teixeira, Natércia; Fernandes, Pedro Alexandrino. "A multi-target approach for hormone-dependent breast cancer: estrogen receptors and aromatase". Paper presented in Encontro de Jovens Investigadores de Biologia Computacional Estrutural, EJIBCE, 2018. Amaral, Cristina; Almeida, Cristina F.; Augusto, Tiago V.; Correia-da-Silva, Georgina; Teixeira, Natércia. "Estrogen-receptor positive breast cancer: Phytocannabinoids as potential adjuvant therapy to overcome Exemestane-acquired resistance". Paper presented in I International Congress about Cannabis and its derivatives: Health, Education and Law, 2017. Almeida, Cristina F.; Augusto, Tiago V.; Correia-da-Silva, Georgina; Teixeira, Natércia; Amaral, Cristina. "The effects of cannabinoids in exemestane-resistant breast cancer cells". Paper presented in 12th YES - Young European Scientist – Meeting, 2017.
Journal article	Bezerra, Patrícia H. A.; Amaral, Cristina; Almeida, Cristina F.; Correia-da-Silva, Georgina; Torqueti, Maria Regina; Teixeira, Natércia. "In Vitro Effects of Combining Genistein with Aromatase Inhibitors: Concerns Regarding Its Consumption during Breast Cancer Treatment". Molecules 28 13 (2023): 4893. http://dx.doi.org/10.3390/molecules28134893. Published • 10.3390/molecules28134893 Almeida, Cristina Ferreira; Teixeira, Natércia; Valente, Maria João; Vinggaard, Anne Marie; Correia-da-Silva, Georgina; Amaral, Cristina. "Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive Breast Tumors: Unveiling Its Benefits with Aromatase Inhibitors". Cancers 15 9 (2023): 2517. http://dx.doi.org/10.3390/cancers15092517. Published • 10.3390/cancers15092517 Amaral, Cristina; Correia-da-Silva, Georgina; Almeida, Cristina Ferreira; Valente, Maria João; Varela, Carla; Tavares-da-Silva, Elisiário; Vinggaard, Anne Marie; Teixeira, Natércia; Roleira, Fernanda M. F.. "An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines". Molecules 28 2 (2023): 789. http://dx.doi.org/10.3390/molecules28020789. Published • 10.3390/molecules28020789 Almeida, Cristina Ferreira; Teixeira, Natércia; Correia-da-Silva, Georgina; Amaral, Cristina. "Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype". Molecules 27 1 (2021): 156. http://dx.doi.org/10.3390/molecules27010156. 10.3390/molecules27010156 Tiago V. Augusto; Cristina Amaral; Cristina F. Almeida; Natércia Teixeira; Georgina Correia-da-Silva. "Differential biological effects of aromatase inhibitors: Apoptosis, autophagy, senescence and modulation of the hormonal status in breast cancer cells". Molecular and Cellular Endocrinology 537 (2021): 111426-111426. https://doi.org/10.1016/j.mce.2021.111426. 10.1016/j.mce.2021.111426 Augusto, Tiago V.; Amaral, Cristina; Wang, Yuanzhong; Chen, Shiuan; Almeida, Cristina F.; Teixeira, Natércia; Correia-da-Silva, Georgina. "Effects of PI3K inhibition in AI-resistant breast cancer cell lines: autophagy, apoptosis, and cell cycle progression". Breast Cancer Research and Treatment 190 2 (2021): 227-240. http://dx.doi.org/10.1007/s10549-021-06376-4. 10.1007/s10549-021-06376-4 Almeida, Cristina Ferreira; Amaral, Cristina; Augusto, Tiago V.; Correia-da-Silva, Georgina; Marques de Andrade, Camila; Torqueti, Maria Regina; Teixeira, Natércia. "The anti-cancer potential of crotoxin in estrogen receptor-positive breast cancer: Its effects and mechanism of action". Toxicon 200 (2021): 69-77. http://dx.doi.org/10.1016/j.toxicon.2021.07.003. 10.1016/j.toxicon.2021.07.003 Almeida, Cristina Ferreira; Teixeira, Natércia; Oliveira, Ana; Augusto, Tiago V.; Correia-da-Silva, Georgina; Ramos, Maria João; Fernandes, Pedro Alexandrino; Amaral, Cristina. "Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs". Biochimie 181 (2020): 65-76. http://dx.doi.org/10.1016/j.biochi.2020.11.023. Published • 10.1016/j.biochi.2020.11.023 Amaral, Cristina; Trouille, Fabien M.; Almeida, Cristina F.; Correia-da-Silva, Georgina; Teixeira, Natércia. "Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: impact on aromatase and steroid receptors". The Journal of Steroid Biochemistry and Molecular Biology (2020): Under revision Almeida, Cristina F.; Oliveira, Ana; Ramos, Maria João; Fernandes, Pedro Alexandrino; Teixeira, Natércia; Amaral, Cristina. "Estrogen receptor-positive (ER+ ) breast cancer treatment: are multi-target compounds the next promising approach?". Biochemical Pharmacology (2020): https://doi.org/10.1016/j.bcp.2020.113989. Published • 10.1016/j.bcp.2020.113989
Thesis / Dissertation	Cristina F. Almeida. "Non-steroidal aromatase inhibitors for hormone-dependent breast cancer: virtual screening and in vitro effects". Master, Universidade do Porto Faculdade de Ciências, 2019.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/02/09	A comparative study of the effects of cannabidiol in combination with aromatase inhibitors in sensitive and resistant breast cancer cells	SPF Meeting 2022 Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2021/02/19	Effects of crotoxin in estrogen receptor-positive breast cancer	SPF Meeting 2021 Sociedade Portuguesa de Farmacologia (Portugal)
2020/11	Tamoxifen bisphenol: a modulator of ERß in estrogen receptor-positive breast cancer	6th International Electronic Conference on Medicinal Chemistry
2020/02/12	A multi-target compound for ER+ breast cancer treatment: Evaluation of its anti-cancer properties	13th Meeting of Young Researchers of University of Porto, IJUP 2020 Universidade do Porto (Porto, Portugal)
2019/11	A novel approach for ER+ breast cancer treatment: A new compound that modulates aromatase and ER	5th International Electronic Conference on Medicinal Chemistry
2019/09/11	Ciência e Sociedade: explorando colaborações em contexto formativo	IV Conferência Rumos da Sociologia do Conhecimento, Ciência e Tecnologia em Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)
2019/02/13	Non-steroidal aromatase inhibitors for hormone-dependent breast cancer: a virtual screening approach	12th Meeting of Young Researchers of University of Porto, IJUP 2019 Universidade do Porto (Porto, Portugal)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2017/11/17 - 2017/11/17	Multidisciplinary colloquium entitled "Resistência a Antibióticos, Diálogo Ciência-Sociedade e o Futuro - ensaiando cenários" open to the whole community and with the participation of experts in different areas, namely, Pharmaceutical Sciences, Microbiology and Social Sciences. The aim of the activity was to discuss the issue of antibiotic resistance in order to improve scientific knowledge and Science-Society dialogue in a current and futuristic perspective. (2017/11/17 - 2017/11/17) Other (Member of the Organising Committee)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2019/10/22 - 2019/10/22	Participation in a workshop entitled "Publishing Workshop for Authors & Reviewers, Editors Round table" promoted by Elsevier. Workshop	Publishing Workshop for Authors & Reviewers, Editors Round table Universidade do Porto Faculdade de Farmácia, Portugal
2019/04/11 - 2019/04/11	Participation in a workshop entitled "How to get your article published" promoted by Elsevier. During this workshop, advices and tips regarding the correct construction of a scientific paper and its submission were given. Workshop	How to get your article published Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/26 - 2018/03/26	Participation in a workshop entitled "Cancer epigenetics: from biology to clinic", in which aspects associated with cancer were addressed. Workshop	XI – ENEBIOQ Décima Primeira Edição do Encontro Nacional de Estudantes de Bioquímica Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/26 - 2018/03/26	Participation in a workshop entitled "Clinical pathology in animal models", in which several issues related to the theme were addressed. Workshop	XI – ENEBIOQ Décima Primeira Edição do Encontro Nacional de Estudantes de Bioquímica Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/04/05 - 2016/04/28	Forensic Sciences Course, focusing on the different aspects of this theme. Other	Curso de Ciências Forenses Universidade do Porto Faculdade de Ciências, Portugal

Distinctions

Award

2019	Best oral communication Universidade do Porto, Portugal

Other distinction

2021	Research Fellowship Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2021	Research Fellowship REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal Fundação para a Ciência e a Tecnologia, Portugal
2019	Research Fellowship Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal