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I finished my MSc degree on Biochemistry, at the University of Aveiro, in 2017, after completing the BSc on Biomedical Sciences from the same University, 2015. During these academic years, I had the opportunity to join Amgen Foundation summer research program, at Institute Pasteur, which resulted in one poster publication at Amgen Cambridge Symposium, as international conference (2015). For my thesis project, I decided to join the Cell Biology laboratory (CNC, University of Coimbra) to develop a project focused on the optimization of chondrogenic differentiation of mesenchymal stem cells (MSCs) using PDMS substrates under the supervision of Dr. Mário Grãos. To diversify my research experience, I tried different research fields to learn new techniques. Therefore, I joined ‘Functional Genomics and RNA-based Therapeutics’ laboratory at CNC, where I performed small-scale screenings using microRNAs and siRNAs on different cell lines using high-content microscopy, to study host-pathogen interactions. These project lead to a methodological article, where I am one of the authors. Currently, I am a research fellow at Life Sciences Mass Spectrometry Lab, at CNC. I am part of a project that aims to identify molecules that can be used to diagnose hypoxic ischemic encephalopathy, a neonatal brain injury disease that has no diagnostic or an effective therapeutic available.
Identification

Personal identification

Full name
INÊS ISABEL NUNES CARAMELO

Citation names

  • CARAMELO, INÊS

Author identifiers

Ciência ID
E712-4152-6BC1
ORCID iD
0000-0002-7794-9762

Email addresses

  • ines.caramelo17@gmail.com (Professional)

Addresses

  • Centre for Neuroscience and Cell Biology (CNC). UC Biotech | Parque Tecnológico de Cantanhede, Núcleo 04 - Lote 8, 3060-197 , Cantanhede, Cantanhede, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Social Biomedical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/01/12 - 2022/06
Ongoing
Product Managment and Business Development (Título de especialista)
Major in Product Manager
Invictus Sciences, Portugal
2020/09/12 - 2020/11
Concluded
Digital Marketing and Business Analytics (Título de especialista)
Major in Digital marketing
Invictus Sciences, Portugal
2020/02 - 2020/02
Concluded
Connecting researchers with society (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra, Portugal
2019/11 - 2019/11
Concluded
Functional Neuroanatomy (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra, Portugal
2019/01 - 2019/03
Concluded
Modular Training in Laboratory Animal Science (Curso de doutoramento (conclusão de unidades curriculares))
Major in Function a + b + special skills
Universidade de Coimbra, Portugal
17
2018/10/15 - 2018/12/15
Concluded
Pharmacovigilance for healthcare professionals (Diploma de especialização)
Major in Farmacovigilância
UNAVE–Associação para a Formação Profissional e Investigação da Universidade de Aveiro (UA), Portugal
Excelente
2017/09/18
Concluded
Biochemistry (Mestrado)
Major in Biomolecular methods
Universidade de Aveiro, Portugal
"Mechanomodulation of Chondrogenic Differentiation of Mesenchymal Stem Cells" (THESIS/DISSERTATION)
17
2015/06/26
Concluded
Biomedical Sciences (Licenciatura)
Major in Molecular minor
Universidade de Aveiro, Portugal
16
Affiliation

Science

Category
Host institution
Employer
2019/10/01 - 2023/12/31 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
CNC.IBILI, Portugal
2018/11/01 - 2019/12/31 Researcher (Research) CNC.IBILI, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017/10/01 - 2018/07/31 Researcher (Research) CNC.IBILI, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/08/01 - 2017/09/18 Research Trainee (Research) CNC.IBILI, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/01 - 2015/09/15 Research Trainee (Research) Institut Pasteur, France
Institut Pasteur, France
2015/01/01 - 2015/02/01 Research Trainee (Research) Universidade Nova de Lisboa Centro de Investigação em Materiais, Portugal
Universidade Nova de Lisboa Centro de Investigação em Materiais, Portugal
Projects

Contract

Designation Funders
2018 - 2021/07/25 Brain Elasticity in Multiple Sclerosis and implications in mechanomodulation of oligodendrocytes: a cellular and clinical approach
PTDC/MED-NEU/29516/2017
Researcher
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2021/07/01 New approaches on Hypoxic-Ischemic Encephalopathy: translational research to diagnose and monitor stem cell therapy
POCI-01-0145-FEDER-029311
Research Fellow
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017 - 2018/07/31 Combining high-throughput and single-cell analyses to study RNA regulators important for the early steps of Campylobacter infection
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Heloísa Gerardo; Tânia Lourenço; CARAMELO, INÊS; José Lopes da Silva; Mário Grãos. "Fabrication and functionalization of cell culture substrates for mechanobiology studies". Paper presented in EuroCellNet COST Action Workshop on Mechanobiology in Migrating Cells, Coimbra, 2019.
Conference poster
  1. CARAMELO, INÊS; Mendes, Vera M; Domingues, Catarina; Mendes, Ana Carolina Santo; Geraldo, A. Margarida; Anjo, Sandra Isabel; Carla Cardoso; et al. "Culturing mesenchymal stem cells at physiological oxygen level or on soft substrate modulates their cellular proteome". Paper presented in 12th International Meeting of the ¿Portuguese Society for Stem Cells ¿and Cell Therapies, 2021.
  2. CARAMELO, INÊS; Mendes, Vera M; Carla Cardoso; Alexandra Dinis; Duarte, Carlos B.; Grãos, Mário; Manadas, Bruno. "Mesenchymal stem cells under physiological conditions as an innovative therapeutic approach for hypoxic-ischemic encephalopathy: a proteomics screening". 2020.
  3. CARAMELO, INÊS; Aleksandr Barinov; Paulo Vieira. "The role of CXCL12/heparan sulfate interactions in the regulation of B cell responses". Paper presented in Amgen Scholars Europe Symposium (Cambridge), 2015.
Journal article
  1. Domingues, Catarina; Geraldo, A. Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A.; et al. "Cofilin-1 Is a Mechanosensitive Regulator of Transcription". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00678.
    10.3389/fcell.2020.00678
  2. Rodrigues Lopes, Ines; Silva, Ricardo Jorge; Caramelo, Ines; Eulalio, Ana; Mano, Miguel. "Shedding light on microRNA function via microscopy-based screening". Methods 152 (2019): 55-64. http://dx.doi.org/10.1016/j.ymeth.2018.09.011.
    Published • 10.1016/j.ymeth.2018.09.011
Thesis / Dissertation
  1. CARAMELO, INÊS. "Mechanomodulation of Chondrogenic Differentiation of Mesenchymal Stem Cells". Master, 2017. http://hdl.handle.net/10773/22537.
Activities

Event organisation

Event name
Type of event (Role)
Institution / Organization
2022/01/18 - 2022/01/19 Organizing Committee BEB Day 2022 (2022/01/18 - 2022/01/19)
Symposium (Member of the Organising Committee)
CNC.IBILI, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/02/23 - 2022/03/11 3 Minute Thesis Competition
Call
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2021/10/13 - 2021/10/13 Science communication activity
Seminar
Stem Cell Awarness Week
Agrupamento de Escolas de Mira, Portugal
2021/09/24 - 2021/09/24 Volunteer (logistics and organization support)
Exhibition
European Researchers Night 2022
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2019/12/04 Determinação da velocidade de transcrição em células humanas sujeitas a substratos com diferentes graus de rigidez
(Thesis) Main arguer
André Matos (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Mentoring / Tutoring

Topic Student name
2021/10 - Current Establishing phosphoproteomis strategies to unravel molecular pathways related to psycothic disorders Eva Ferro
2020/09/15 - Current Metabolomics screening of oxygen-glucose deprived neurons as a model of hypoxic-ischemic encephalopathy for newborns Diana Gaspar
2021/05/01 - 2021/05/31 Characterization of the MSCs secretome using MS Maria Francisca Madeira
Distinctions

Other distinction

2021 Finalist 3 minute thesis competition
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019 PhD scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2015 Amgen Foundation Summer Scolarship (Europe)
Amgen Foundation Inc, United States