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Prof Ana Martinez is research professor at Biological Research Center of Spanish Council for Research (CIB-CSIC) and member of Biomedical Research center on neurodegenerative diseases (CIBERNEDISCiii). Her main interests are focused in the Discovery and development of effective treatments for CNS unmet diseases, such as Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, spinal cord trauma and multiple sclerosis. Her work is in close conection with the pharmaceutical sector and many of her results are transferred to the productive sphere. She was R&D director of NeuroPharma from 2002-08 and founder of the spin-off ANKAR Pharma in 2014. Thus, some of her drug candidates are on clinical trials, such as tideglusib, a GSK3 inhibitor. Since 2009, Prof Martinez has led different projects to discover new drugs for ALS and currently is the coordinator of a large network, called ELA_Madrid, that joints multidisciplinar efforts of research groups from hospitals, university and CSIC all of them based in Madrid with the main goal to discover and advance new drug candidates for this devastating disease. Different compounds such as the PKis here mentioned, but also modulator of mitophagy and/or NfR2 cell signalling have been idetified with great potential for the disease. Most significant outputs in more than 30 years of experience in drug discovery and development both in academic and industrial environments, are to move three compounds born in her lab to clinical trials. Tideglusib, a GSK3 inhibiotr, is now in phase III for miotonyc dystrophy and ready to start a Phase II for ALS. NP-61, a modulator of beta-amiloide finished phase I in 2008, and S14, a PDE7 inhibitor, is pending approval in AEMPS for Parkinson's disease. Author of > 270 publications (h=46), >30 active patents (6 of them transferred to ARACLON, AMO Pharma and ANKAR Pharma), several international conferences and editor of >6 books. ORCID: 0000-0002-2707-8110. Since 2018, she is the coordinator of a solid research network funded by Madrid Community to develop new drugs for ALS. Finally, her laboratory is CIBERNED member and validated chemistry site of EUOPENSCREEN. She is mentor of 12 PhD (6 more ongoing), >35 Master thesis and many postdoc trainings and ERASMUS placements (https://www.cib.csic.es/research/structural-and-chemical-biology/translational-medicinal-andbiological- chemistry). She is also member of editorial boards: Curr Med Chem, Mini Rev Med Chem, Recent Patents CNS and book collections (RSC Drug Discovery Serie). She is reviewer in different programs, being member of Pharm and Med Sciences pannel of FWO (Flemish research agency), expert of the European Commision (EX2006C132745) and reviewer of ANEP, AEI, international agencies (France, Austria, Portugal, UK and Italy) and private associations (Wellcome trust, Alzheimer Association, AFM, Weston Brain Inst., etc.)
Identification

Personal identification

Full name
Ana Martinez

Citation names

  • Martinez, Ana

Author identifiers

Ciência ID
E31B-DC78-4ADE
Researcher Id
L-6414-2014
Scopus Author Id
74040254547

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian (Mother tongue)
Education
Degree Classification
2005
Concluded
Bussiness Development (Mestrado)
Universidad de Navarra IESE Business School - Madrid Campus, Spain
1987
Concluded
Medicinal Chemistry (Doutoramento)
Universidad Complutense de Madrid, Spain
1984
Concluded
Organic Chemistry (Licenciatura)
Universidad Complutense de Madrid, Spain
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2009 - Current Full Professor (University Teacher) Consejo Superior de Investigaciones Científicas (CSIC), Spain
Projects

Grant

Designation Funders
2019/02 - Current Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond EU-OPENSCREEN-DRIVE
GA 823893
Principal investigator
EU Framework Programme for Research and Innovation Excellent Science
Ongoing
2018/07 - Current Spanish network of drug discovery
SAF2017-90913-REDT
Principal investigator
2018/01/01 - Current Design and development of innovative drug for Amyotrophic Lateral Sclerosis (ELA-Madrid-CM)
B2017/BMD3813
Principal investigator
2017/01/01 - Current Multitarget-designed small molecules targeting protein kinase and BACE1: A new approach for prevention and treatment of cognitive disorders
SAF2016-76693-R
Principal investigator
2021/11/01 - 2024/10/31 Targeting TDP-43 with protein kinase inhibitors: a effective and measurable therapy for ALS (Drugs4ALS)
HR21-00931
Principal investigator
Consejo Superior de Investigaciones Científicas (CSIC), Spain
La Caixa Foundation-Luzón Foundation
Ongoing
2020/06/01 - 2023 Aging and neurodegeneration targeting by protein kinase small molecules inhibitors
PID2019-105600RB-100
Principal investigator
Consejo Superior de Investigaciones Científicas, Spain

Centro de Investigaciones Biológicas, Spain
Gobierno de España Agencia Estatal de Investigación
Ongoing
2021/09/01 - 2022/08/31 TDP-43 modulators: moving towards clinical trials using ALS personalized celular models
FHNA
Principal investigator
Consejo Superior de Investigaciones Científicas (CSIC), Spain
HNA Foundation
Ongoing
2015/01/01 - 2018/12/31 Development of innovative therapies for Parkinson’s disease
RTC-2015-3439-1
Principal investigator
Concluded
2016/06/01 - 2017/05/31 Eyes: a diagnosis window to the brain
SAF2015-72325-EXP
Principal investigator

Contract

Designation Funders
2018/01/01 - 2021/12/31 Design and development of innovative drugs for the Amyotrophic Lateral Sclerosis therapy.
B2017/BMD-3813
Principal investigator
Consejo Superior de Investigaciones Científicas, Spain

Centro de Investigaciones Biológicas, Spain
Madrid Autonomic Community
Ongoing
Outputs

Publications

Book chapter
  1. Sánchez-Cruz, Alonso; Martínez, Ana; de la Rosa, Enrique J.; Hernández-Sánchez, Catalina. "GSK-3 Inhibitors: From the Brain to the Retina and Back Again". In Advances in Experimental Medicine and Biology, 437-441. Springer International Publishing, 2019.
    10.1007/978-3-030-27378-1_72
  2. Sebastián-Pérez, Víctor; Martínez, María J.; Gil, Carmen; Campillo, Nuria E.; Martínez, Ana; Ponzoni, Ignacio. "QSAR Modelling for Drug Discovery: Predicting the Activity of LRRK2 Inhibitors for Parkinson’s Disease Using Cheminformatics Approaches". In Practical Applications of Computational Biology and Bioinformatics, 12th International Conference, 63-70. Springer International Publishing, 2018.
    10.1007/978-3-319-98702-6_8
  3. Martinez, Ana; Gil, Carmen. "Chapter 8. Medicinal Chemistry Strategies to Discover New Leishmanicidal Drugs". In Drug Discovery for Leishmaniasis, 153-178. Royal Society of Chemistry, 2018.
    10.1039/9781788010177-00153
  4. Martinez, Ana; Gil, Carmen. "Chapter 9. Heterocycles Containing Nitrogen and Sulfur as Potent Biologically Active Scaffolds". In Privileged Scaffolds in Medicinal Chemistry, 231-261. Royal Society of Chemistry, 2016.
    10.1039/9781782622246-00231
Journal article
  1. Berenguer, Eduardo; Carneros, Elena; Pérez-Pérez, Yolanda; Gil, Carmen; Martínez, Ana; Testillano, Pilar S. "Small molecule inhibitors of mammalian GSK-3ß promote in vitro plant cell reprogramming and somatic embryogenesis in crop and forest species". Journal of Experimental Botany 72 22 (2021): 7808-7825. http://dx.doi.org/10.1093/jxb/erab365.
    10.1093/jxb/erab365
  2. Nozal, Vanesa; García-Rubia, Alfonso; Cuevas, Eva P.; Pérez, Concepción; Tosat-Bitrián, Carlota; Bartolomé, Fernando; Carro, Eva; et al. "From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis". Angewandte Chemie International Edition 60 35 (2021): 19344-19354. http://dx.doi.org/10.1002/anie.202106295.
    10.1002/anie.202106295
  3. Kocak, Muhammed; Ezazi Erdi, Saba; Jorba, Guillem; Maestro, Inés; Farrés, Judith; Kirkin, Vladimir; Martinez, Ana; Pless, Ole. "Targeting autophagy in disease: established and new strategies". Autophagy (2021): 1-23. http://dx.doi.org/10.1080/15548627.2021.1936359.
    10.1080/15548627.2021.1936359
  4. Rico, Anabel; Guembelzu, Garazi; Palomo, Valle; Martínez, Ana; Aiastui, Ana; Casas-Fraile, Leire; Valls, Andrea; López de Munain, Adolfo; Sáenz, Amets. "Allosteric Modulation of GSK-3ß as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related". International Journal of Molecular Sciences 22 14 (2021): 7367. http://dx.doi.org/10.3390/ijms22147367.
    10.3390/ijms22147367
  5. García-Cárceles, Javier; Caballero, Elena; Gil, Carmen; Martínez, Ana. "Kinase Inhibitors as Underexplored Antiviral Agents". Journal of Medicinal Chemistry 65 2 (2021): 935-954. http://dx.doi.org/10.1021/acs.jmedchem.1c00302.
    10.1021/acs.jmedchem.1c00302
  6. Gil, Carmen; Martinez, Ana. "Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?". Expert Opinion on Drug Discovery (2021): 1-3. http://dx.doi.org/10.1080/17460441.2021.1912733.
    10.1080/17460441.2021.1912733
  7. Ginex, Tiziana; Garaigorta, Urtzi; Ramírez, David; Castro, Victoria; Nozal, Vanesa; Maestro, Inés; García-Cárceles, Javier; et al. "Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods". Pharmaceuticals 14 4 (2021): 332. http://dx.doi.org/10.3390/ph14040332.
    10.3390/ph14040332
  8. Grieco, Ilenia; Bissaro, Maicol; Tiz, Davide Benedetto; Perez, Daniel I.; Perez, Conception; Martinez, Ana; Redenti, Sara; et al. "Developing novel classes of protein kinase CK1d inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems". European Journal of Medicinal Chemistry 216 (2021): 113331. http://dx.doi.org/10.1016/j.ejmech.2021.113331.
    10.1016/j.ejmech.2021.113331
  9. Nozal, Vanesa; Rojas-Prats, Elisa; Maestro, Inés; Gil, Carmen; Perez, Daniel I.; Martinez, Ana. "Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles". International Journal of Molecular Sciences 22 6 (2021): 3206. http://dx.doi.org/10.3390/ijms22063206.
    10.3390/ijms22063206
  10. Lastres-Becker, Isabel; Porras, Gracia; Arribas-Blázquez, Marina; Maestro, Inés; Borrego-Hernández, Daniel; Boya, Patricia; Cerdán, Sebastián; et al. "Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy". International Journal of Molecular Sciences 22 6 (2021): 3007. http://dx.doi.org/10.3390/ijms22063007.
    10.3390/ijms22063007
  11. Benítez-Fernández, Rocío; Melero-Jerez, Carolina; Gil, Carmen; de la Rosa, Enrique J.; Martínez, Ana; de Castro, Fernando. "Dynamics of Central Remyelination and Treatment Evolution in a Model of Multiple Sclerosis with Optic Coherence Tomography". International Journal of Molecular Sciences 22 5 (2021): 2440. http://dx.doi.org/10.3390/ijms22052440.
    10.3390/ijms22052440
  12. Lasala, Fátima; García-Rubia, Alfonso; Requena, Carlos; Galindo, Inmaculada; Cuesta-Geijo, Miguel Angel; García-Dorival, Isabel; Bueno, Paula; et al. "Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses". Antiviral Research 186 (2021): 105011. http://dx.doi.org/10.1016/j.antiviral.2021.105011.
    10.1016/j.antiviral.2021.105011
  13. Rojas-Prats, Elisa; Tosat-Bitrián, Carlota; Martínez-González, Loreto; Nozal, Vanesa; Pérez, Daniel I.; Martínez, Ana. "Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles". Pharmaceutics 13 2 (2021): 180. http://dx.doi.org/10.3390/pharmaceutics13020180.
    10.3390/pharmaceutics13020180
  14. Davies, Matthew P.; Benitez, Rocio; Perez, Concepción; Jakupovic, Sven; Welsby, Philip; Rzepecka, Klaudia; Alder, Jane; et al. "Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3ß". Journal of Medicinal Chemistry 64 3 (2021): 1497-1509. http://dx.doi.org/10.1021/acs.jmedchem.0c01568.
    10.1021/acs.jmedchem.0c01568
  15. Madruga, Enrique; Maestro, Inés; Martínez, Ana. "Mitophagy Modulation, a New Player in the Race against ALS". International Journal of Molecular Sciences 22 2 (2021): 740. http://dx.doi.org/10.3390/ijms22020740.
    10.3390/ijms22020740
  16. Rojas-Prats, Elisa; Martinez-Gonzalez, Loreto; Gonzalo-Consuegra, Claudia; Liachko, Nicole F.; Perez, Concepción; Ramírez, David; Kraemer, Brian C.; et al. "Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis". European Journal of Medicinal Chemistry 210 (2021): 112968. http://dx.doi.org/10.1016/j.ejmech.2020.112968.
    10.1016/j.ejmech.2020.112968
  17. Palomo, Valle; Nozal, Vanesa; Rojas-Prats, Elisa; Gil, Carmen; Martinez, Ana. "Protein kinase inhibitors for amyotrophic lateral sclerosis therapy". British Journal of Pharmacology 178 6 (2020): 1316-1335. http://dx.doi.org/10.1111/bph.15221.
    10.1111/bph.15221
  18. Vaca, Gabriela; Martinez-Gonzalez, Loreto; Fernandez, Ana; Rojas-Prats, Elisa; Porras, Gracia; Cuevas, Eva P.; Gil, Carmen; Martinez, Ana; Martin-Requero, Ángeles. "Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)". Journal of Neurochemistry 156 3 (2020): 379-390. http://dx.doi.org/10.1111/jnc.15118.
    10.1111/jnc.15118
  19. Gil, Carmen; Ginex, Tiziana; Maestro, Inés; Nozal, Vanesa; Barrado-Gil, Lucía; Cuesta-Geijo, Miguel Ángel; Urquiza, Jesús; et al. "COVID-19: Drug Targets and Potential Treatments". Journal of Medicinal Chemistry 63 21 (2020): 12359-12386. http://dx.doi.org/10.1021/acs.jmedchem.0c00606.
    10.1021/acs.jmedchem.0c00606
  20. Martínez-González, Loreto; Rodríguez-Cueto, Carmen; Cabezudo, Diego; Bartolomé, Fernando; Andrés-Benito, Pol; Ferrer, Isidro; Gil, Carmen; et al. "Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1d kinase inhibitor treatment". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-61265-y.
    10.1038/s41598-020-61265-y
  21. Maestro, Inés; Boya, Patricia; Martinez, Ana. "Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases". Expert Opinion on Therapeutic Targets 24 3 (2020): 231-243. http://dx.doi.org/10.1080/14728222.2020.1730328.
    10.1080/14728222.2020.1730328
  22. Sebastian-Perez, Victor; García-Rubia, Alfonso; Seif el-Din, Sayed H.; Sabra, Abdel-Nasser A.; El-Lakkany, Naglaa M.; William, Samia; Blundell, Tom L.; et al. "Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools". Journal of Enzyme Inhibition and Medicinal Chemistry 35 1 (2020): 511-523. http://dx.doi.org/10.1080/14756366.2020.1712595.
    10.1080/14756366.2020.1712595
  23. Lassagne, Frédéric; Duguépéroux, Camille; Roca, Carlos; Perez, Concepcion; Martinez, Ana; Baratte, Blandine; Robert, Thomas; et al. "From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)". Organic & Biomolecular Chemistry 18 1 (2020): 154-162. http://dx.doi.org/10.1039/c9ob02002k.
    10.1039/c9ob02002k
  24. Zaldivar-Diez, Josefa; Li, Lingling; Garcia, Ana M.; Zhao, Wen-Ning; Medina-Menendez, Cristina; Haggarty, Stephen. J.; Gil, Carmen; Morales, Aixa V.; Martinez, Ana. "Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate". Journal of Medicinal Chemistry 63 5 (2019): 2638-2655. http://dx.doi.org/10.1021/acs.jmedchem.9b01752.
    10.1021/acs.jmedchem.9b01752
  25. Morales-Navarro, Samuel; Prent-Peñaloza, Luis; Rodríguez Núñez, Yeray A.; Sánchez-Aros, Laura; Forero-Doria, Oscar; González, Wendy; Campilllo, Nuria E.; et al. "Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases". Processes 7 12 (2019): 940. http://dx.doi.org/10.3390/pr7120940.
    10.3390/pr7120940
  26. Martínez de Iturrate, Paula; Sebastián-Pérez, Victor; Nácher-Vázquez, Montserrat; Tremper, Catherine S.; Smirlis, Despina; Martín, Julio; Martínez, Ana; et al. "Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3". Journal of Enzyme Inhibition and Medicinal Chemistry 35 1 (2019): 199-210. http://dx.doi.org/10.1080/14756366.2019.1693704.
    10.1080/14756366.2019.1693704
  27. Gürbüz, Perihan; Martinez, Ana; Pérez, Concepción; Martínez-González, Loreto; Göger, Fatih; Ayran, Irem. "Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3ß, ß-secretase, and casein kinase 1d". Industrial Crops and Products 138 (2019): 111431. http://dx.doi.org/10.1016/j.indcrop.2019.05.080.
    10.1016/j.indcrop.2019.05.080
  28. Wang, Mei; Weng, Wen-Chin; Stock, Lauren; Lindquist, Diana; Martinez, Ana; Gourdon, Genevieve; Timchenko, Nikolai; Snape, Mike; Timchenko, Lubov. "Correction of Glycogen Synthase Kinase 3ß in Myotonic Dystrophy 1 Reduces the Mutant RNA and Improves Postnatal Survival of DMSXL Mice". Molecular and Cellular Biology 39 21 (2019): http://dx.doi.org/10.1128/mcb.00155-19.
    10.1128/mcb.00155-19
  29. Venter, Jana; Perez, Concepción; van Otterlo, Willem A.L.; Martínez, Ana; Blackie, Margaret A.L.. "1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation". Bioorganic & Medicinal Chemistry Letters 29 13 (2019): 1597-1600. http://dx.doi.org/10.1016/j.bmcl.2019.04.049.
    10.1016/j.bmcl.2019.04.049
  30. Sebastián-Pérez, Víctor; Schroeder, Susanne; Munday, Jane C; van der Meer, Tiffany; Zaldívar-Díez, Josefa; Siderius, Marco; de Koning, Harry P; et al. "Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis". Future Medicinal Chemistry 11 14 (2019): 1703-1720. http://dx.doi.org/10.4155/fmc-2018-0592.
    10.4155/fmc-2018-0592
  31. Canal-Martín, Andrea; Sastre, Javier; Sánchez-Barrena, María José; Canales, Angeles; Baldominos, Sara; Pascual, Naiara; Martínez-González, Loreto; et al. "Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-10627-w.
    10.1038/s41467-019-10627-w
  32. de Andrade, Peterson; Mantoani, Susimaire P.; Gonçalves Nunes, Paulo Sérgio; Magadán, Carlos Roca; Pérez, Concepción; Xavier, Danilo Jordão; Hojo, Elza Tiemi Sakamoto; et al. "Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease". Bioorganic & Medicinal Chemistry 27 6 (2019): 931-943. http://dx.doi.org/10.1016/j.bmc.2018.12.030.
    10.1016/j.bmc.2018.12.030
  33. Palomo, Valle; Tosat-Bitrian, Carlota; Nozal, Vanesa; Nagaraj, Siranjeevi; Martin-Requero, Angeles; Martinez, Ana. "TDP-43: A Key Therapeutic Target beyond Amyotrophic Lateral Sclerosis". ACS Chemical Neuroscience 10 3 (2019): 1183-1196. http://dx.doi.org/10.1021/acschemneuro.9b00026.
    10.1021/acschemneuro.9b00026
  34. Sebastián-Pérez, Víctor; Martínez, María Jimena; Gil, Carmen; Campillo, Nuria Eugenia; Martínez, Ana; Ponzoni, Ignacio. "QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson’s Disease". Journal of Integrative Bioinformatics 16 1 (2019): http://dx.doi.org/10.1515/jib-2018-0063.
    10.1515/jib-2018-0063
  35. Redenti, Sara; Marcovich, Irene; De Vita, Teresa; Pérez, Concepción; De Zorzi, Rita; Demitri, Nicola; Perez, Daniel I.; et al. "A Triazolotriazine-Based Dual GSK-3ß/CK-1d Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition". ChemMedChem 14 3 (2019): 310-314. http://dx.doi.org/10.1002/cmdc.201800778.
    10.1002/cmdc.201800778
  36. Nozal, Vanesa; Martinez, Ana. "Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases". European Journal of Medicinal Chemistry 161 (2019): 39-47. http://dx.doi.org/10.1016/j.ejmech.2018.10.030.
    10.1016/j.ejmech.2018.10.030
  37. Sciú, M. Lourdes; Sebastián-Pérez, Victor; Martinez-Gonzalez, Loreto; Benitez, Rocio; Perez, Daniel I.; Pérez, Concepción; Campillo, Nuria E.; Martinez, Ana; Moyano, E. Laura. "Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3". Journal of Enzyme Inhibition and Medicinal Chemistry 34 1 (2018): 87-96. http://dx.doi.org/10.1080/14756366.2018.1530223.
    10.1080/14756366.2018.1530223
  38. Alten, Baris; Yesiltepe, Metin; Bayraktar, Erva; Tas, Sadik Taskin; Gocmen, Ayse Yesim; Kursungoz, Canan; Martinez, Ana; Sara, Yildirim. "High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses". British Journal of Pharmacology 175 24 (2018): 4450-4463. http://dx.doi.org/10.1111/bph.14500.
    10.1111/bph.14500
  39. Uliassi, Elisa; Peña-Altamira, Luis Emiliano; Morales, Aixa V.; Massenzio, Francesca; Petralla, Sabrina; Rossi, Michele; Roberti, Marinella; et al. "A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential". ACS Chemical Neuroscience 10 1 (2018): 279-294. http://dx.doi.org/10.1021/acschemneuro.8b00242.
    10.1021/acschemneuro.8b00242
  40. Kraft, Claudine; Boya, Patricia; Codogno, Patrice; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Farrés, Judith; Kirkin, Vladimir; et al. "Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy". Autophagy 15 2 (2018): 347-351. http://dx.doi.org/10.1080/15548627.2018.1515532.
    10.1080/15548627.2018.1515532
  41. Sebastián-Pérez, Victor; Hendrickx, Sarah; Munday, Jane C.; Kalejaiye, Titilola; Martínez, Ana; Campillo, Nuria E.; de Koning, Harry; et al. "Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-LeishmaniaTherapy". Antimicrobial Agents and Chemotherapy 62 10 (2018): http://dx.doi.org/10.1128/aac.00603-18.
    10.1128/aac.00603-18
  42. Gandini, Annachiara; Bartolini, Manuela; Tedesco, Daniele; Martinez-Gonzalez, Loreto; Roca, Carlos; Campillo, Nuria E.; Zaldivar-Diez, Josefa; et al. "Tau-Centric Multitarget Approach for Alzheimer’s Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3ß and Tau-Aggregation Inhibitors". Journal of Medicinal Chemistry 61 17 (2018): 7640-7656. http://dx.doi.org/10.1021/acs.jmedchem.8b00610.
    10.1021/acs.jmedchem.8b00610
  43. Posa, Diana; Martínez-González, Loreto; Bartolomé, Fernando; Nagaraj, Siranjeevi; Porras, Gracia; Martínez, Ana; Martín-Requero, Ángeles. "Recapitulation of Pathological TDP-43 Features in Immortalized Lymphocytes from Sporadic ALS Patients". Molecular Neurobiology 56 4 (2018): 2424-2432. http://dx.doi.org/10.1007/s12035-018-1249-8.
    10.1007/s12035-018-1249-8
  44. Roca, Carlos; Martinez-González, Loreto; Daniel-Mozo, Miguel; Sastre, Javier; Infantes, Lourdes; Mansilla, Alicia; Chaves-Sanjuan, Antonio; et al. "Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators". Journal of Medicinal Chemistry 61 14 (2018): 5910-5921. http://dx.doi.org/10.1021/acs.jmedchem.8b00088.
    10.1021/acs.jmedchem.8b00088
  45. Decara, Juan; Serrano, Antonia; Pavón, Francisco Javier; Rivera, Patricia; Arco, Rocio; Gavito, Ana; Vargas, Antonio; et al. "The adiponectin promoter activator NP-1 induces high levels of circulating TNFa and weight loss in obese (fa/fa) Zucker rats". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-27871-7.
    10.1038/s41598-018-27871-7
  46. Sánchez-Cruz, Alonso; Villarejo-Zori, Beatriz; Marchena, Miguel; Zaldivar-Díez, Josefa; Palomo, Valle; Gil, Carmen; Lizasoain, Ignacio; et al. "Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa". Molecular Neurodegeneration 13 1 (2018): http://dx.doi.org/10.1186/s13024-018-0251-y.
    10.1186/s13024-018-0251-y
  47. Cheng, Yuyan; Desse, Sachi; Martinez, Ana; Worthen, Ryan J.; Jope, Richard S.; Beurel, Eleonore. "TNFa disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice". Brain, Behavior, and Immunity 69 (2018): 556-567. http://dx.doi.org/10.1016/j.bbi.2018.02.003.
    10.1016/j.bbi.2018.02.003
  48. Bartolome, Fernando; de la Cueva, Macarena; Pascual, Consuelo; Antequera, Desiree; Fernandez, Tamara; Gil, Carmen; Martinez, Ana; Carro, Eva. "Amyloid ß-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition". Alzheimer's Research & Therapy 10 1 (2018): http://dx.doi.org/10.1186/s13195-018-0352-4.
    10.1186/s13195-018-0352-4
  49. Chierrito, Talita P.C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Sebastian-Pérez, Victor; Martínez-Gonzalez, Loreto; Pérez, Daniel I.; Perez, Concepción; et al. "Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors". European Journal of Medicinal Chemistry 145 (2018): 431-444. http://dx.doi.org/10.1016/j.ejmech.2018.01.007.
    10.1016/j.ejmech.2018.01.007
  50. Benek, Ondrej; Hroch, Lukas; Aitken, Laura; Gunn-Moore, Frank; Vinklarova, Lucie; Kuca, Kamil; Perez, Daniel I.; et al. "1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders". Journal of Enzyme Inhibition and Medicinal Chemistry 33 1 (2018): 665-670. http://dx.doi.org/10.1080/14756366.2018.1445736.
    10.1080/14756366.2018.1445736
  51. Roca, Carlos; Requena, Carlos; Sebastián-Pérez, Víctor; Malhotra, Sony; Radoux, Chris; Pérez, Concepción; Martinez, Ana; et al. "Identification of new allosteric sites and modulators of AChE through computational and experimental tools". Journal of Enzyme Inhibition and Medicinal Chemistry 33 1 (2018): 1034-1047. http://dx.doi.org/10.1080/14756366.2018.1476502.
    10.1080/14756366.2018.1476502
  52. Chierrito, Talita P.C.; Pedersoli-Mantoani, Susimaire; Roca, Carlos; Requena, Carlos; Sebastian-Perez, Victor; Castillo, Willian O.; Moreira, Natalia C.S.; et al. "From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease". European Journal of Medicinal Chemistry 139 (2017): 773-791. http://dx.doi.org/10.1016/j.ejmech.2017.08.051.
    10.1016/j.ejmech.2017.08.051
  53. García, Ana; Brea, José; González-García, Alejandro; Pérez, Concepción; Cadavid, María Isabel; Loza, María Isabel; Martinez, Ana; Gil, Carmen. "Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects". Molecules 22 9 (2017): 1472. http://dx.doi.org/10.3390/molecules22091472.
    10.3390/molecules22091472
  54. Salado, Irene G.; Zaldivar-Diez, Josefa; Sebastián-Pérez, Víctor; Li, Lingling; Geiger, Larissa; González, Silvia; Campillo, Nuria E.; et al. "Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents". European Journal of Medicinal Chemistry 138 (2017): 328-342. http://dx.doi.org/10.1016/j.ejmech.2017.06.060.
    10.1016/j.ejmech.2017.06.060
  55. Sebastián-Pérez, Víctor; Roca, Carlos; Awale, Mahendra; Reymond, Jean-Louis; Martinez, Ana; Gil, Carmen; Campillo, Nuria E.. "Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits". Journal of Chemical Information and Modeling 57 9 (2017): 2143-2151. http://dx.doi.org/10.1021/acs.jcim.7b00401.
    10.1021/acs.jcim.7b00401
  56. Morales-Garcia, José A.; Salado, Irene G.; Sanz-San Cristobal, Marina; Gil, Carmen; Pérez-Castillo, Ana; Martínez, Ana; Pérez, Daniel I.. "Biological and Pharmacological Characterization of Benzothiazole-Based CK-1d Inhibitors in Models of Parkinson’s Disease". ACS Omega 2 8 (2017): 5215-5220. http://dx.doi.org/10.1021/acsomega.7b00869.
    10.1021/acsomega.7b00869
  57. Palomo, Valle; Perez, Daniel I.; Roca, Carlos; Anderson, Cara; Rodríguez-Muela, Natalia; Perez, Concepción; Morales-Garcia, Jose A.; et al. "Subtly Modulating Glycogen Synthase Kinase 3 ß: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases". Journal of Medicinal Chemistry 60 12 (2017): 4983-5001. http://dx.doi.org/10.1021/acs.jmedchem.7b00395.
    10.1021/acs.jmedchem.7b00395
  58. García, Ana M; Salado, Irene G; Perez, Daniel I; Brea, José; Morales-García, Jose A; González-García, Alejandro; Cadavid, María Isabel; et al. "Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson’s disease". Future Medicinal Chemistry 9 8 (2017): 731-748. http://dx.doi.org/10.4155/fmc-2017-0005.
    10.4155/fmc-2017-0005
  59. Contreras, Ana; Del Rio, Danila; Martínez, Ana; Gil, Carmen; Morales, Lidia; Ruiz-Gayo, Mariano; Del Olmo, Nuria. "Inhibition of hippocampal long-term potentiation by high-fat diets". NeuroReport 28 6 (2017): 354-359. http://dx.doi.org/10.1097/wnr.0000000000000774.
    10.1097/wnr.0000000000000774
  60. Pérez-Domper, Paloma; Palomo, Valle; Gradari, Simona; Gil, Carmen; de Ceballos, María L.; Martínez, Ana; Trejo, Jose Luis. "The GSK-3-inhibitor VP2.51 produces antidepressant effects associated with adult hippocampal neurogenesis". Neuropharmacology 116 (2017): 174-187. http://dx.doi.org/10.1016/j.neuropharm.2016.12.019.
    10.1016/j.neuropharm.2016.12.019
  61. Pardo, Marta; Cheng, Yuyan; Velmeshev, Dmitry; Magistri, Marco; Eldar-Finkelman, Hagit; Martinez, Ana; Faghihi, Mohammad A.; Jope, Richard S.; Beurel, Eleonore. "Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice". JCI Insight 2 6 (2017): http://dx.doi.org/10.1172/jci.insight.91782.
    10.1172/jci.insight.91782
  62. Martinez, Ana; Palomo Ruiz, Maria del Valle; Perez, Daniel I.; Gil, Carmen. "Drugs in clinical development for the treatment of amyotrophic lateral sclerosis". Expert Opinion on Investigational Drugs 26 4 (2017): 403-414. http://dx.doi.org/10.1080/13543784.2017.1302426.
    10.1080/13543784.2017.1302426
  63. Medina-Rodríguez, Eva María; Bribián, Ana; Boyd, Amanda; Palomo, Valle; Pastor, Jesús; Lagares, Alfonso; Gil, Carmen; et al. "Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep43545.
    10.1038/srep43545
  64. Huang, Sammen; Wang, Haitao; Turlova, Ekaterina; Abussaud, Ahmed; Ji, Xiang; Britto, Luiz R.; Miller, Steven P.; et al. "GSK-3ß inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice". CNS Neuroscience & Therapeutics 23 5 (2017): 405-415. http://dx.doi.org/10.1111/cns.12683.
    10.1111/cns.12683
  65. Martín-Álvarez, R.; Paúl-Fernández, N.; Palomo, V.; Gil, C.; Martínez, A.; Mengod, G.. "A preliminary investigation of phoshodiesterase 7 inhibitor VP3.15 as therapeutic agent for the treatment of experimental autoimmune encephalomyelitis mice". Journal of Chemical Neuroanatomy 80 (2017): 27-36. http://dx.doi.org/10.1016/j.jchemneu.2016.12.001.
    10.1016/j.jchemneu.2016.12.001
  66. Mansilla, Alicia; Chaves-Sanjuan, Antonio; Campillo, Nuria E.; Semelidou, Ourania; Martínez-González, Loreto; Infantes, Lourdes; González-Rubio, Juana María; et al. "Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome". Proceedings of the National Academy of Sciences 114 6 (2017): E999-E1008. http://dx.doi.org/10.1073/pnas.1611089114.
    10.1073/pnas.1611089114
  67. Marchena, Miguel; Villarejo-Zori, Beatriz; Zaldivar-Diez, Josefa; Palomo, Valle; Gil, Carmen; Hernández-Sánchez, Catalina; Martínez, Ana; de la Rosa, Enrique J.. "Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa". Journal of Enzyme Inhibition and Medicinal Chemistry 32 1 (2017): 522-526. http://dx.doi.org/10.1080/14756366.2016.1265522.
    10.1080/14756366.2016.1265522
  68. Palomo, Valle; Martinez, Ana. "Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015)". Expert Opinion on Therapeutic Patents 27 6 (2016): 657-666. http://dx.doi.org/10.1080/13543776.2017.1259412.
    10.1080/13543776.2017.1259412
  69. M. Garcia, Ana; Martinez, Ana; Gil, Carmen. "Enhancing cAMP Levels as Strategy for the Treatment of Neuropsychiatric Disorders". Current Topics in Medicinal Chemistry 16 29 (2016): 3527-3535. http://dx.doi.org/10.2174/1568026616666160426151306.
    10.2174/1568026616666160426151306
  70. Wang, Haitao; Huang, Sammen; Yan, Kuipo; Fang, Xiaoyan; Abussaud, Ahmed; Martinez, Ana; Sun, Hong-Shuo; Feng, Zhong-Ping. "Tideglusib, a chemical inhibitor of GSK3ß, attenuates hypoxic-ischemic brain injury in neonatal mice". Biochimica et Biophysica Acta (BBA) - General Subjects 1860 10 (2016): 2076-2085. http://dx.doi.org/10.1016/j.bbagen.2016.06.027.
    10.1016/j.bbagen.2016.06.027
  71. Morales-Garcia, Jose A.; Echeverry-Alzate, Victor; Alonso-Gil, Sandra; Sanz-SanCristobal, Marina; Lopez-Moreno, Jose A.; Gil, Carmen; Martinez, Ana; Santos, Angel; Perez-Castillo, Ana. "Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo". STEM CELLS 35 2 (2016): 458-472. http://dx.doi.org/10.1002/stem.2480.
    10.1002/stem.2480
  72. de Munck, Estefanía; Palomo, Valle; Muñoz-Sáez, Emma; Perez, Daniel I.; Gómez-Miguel, Begoña; Solas, M. Teresa; Gil, Carmen; Martínez, Ana; Arahuetes, Rosa M.. "Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy". PLOS ONE 11 9 (2016): e0162723. http://dx.doi.org/10.1371/journal.pone.0162723.
    10.1371/journal.pone.0162723
  73. Silva, Tiago; Mohamed, Tarek; Shakeri, Arash; Rao, Praveen P. N.; Martínez-González, Loreto; Pérez, Daniel I.; Martínez, Ana; et al. "Development of Blood–Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity". Journal of Medicinal Chemistry 59 16 (2016): 7584-7597. http://dx.doi.org/10.1021/acs.jmedchem.6b00666.
    10.1021/acs.jmedchem.6b00666
  74. Sebastián-Pérez, Víctor; Manoli, Maria-Tsampika; Pérez, Daniel I.; Gil, Carmen; Mellado, Emilia; Martínez, Ana; Espeso, Eduardo A.; Campillo, Nuria E.. "New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth". European Journal of Medicinal Chemistry 116 (2016): 281-289. http://dx.doi.org/10.1016/j.ejmech.2016.03.035.
    10.1016/j.ejmech.2016.03.035
  75. Alquezar, Carolina; Salado, Irene G.; de la Encarnación, Ana; Pérez, Daniel I.; Moreno, Fermín; Gil, Carmen; de Munain, Adolfo López; Martínez, Ana; Martín-Requero, Ángeles. "Targeting TDP-43 phosphorylation by Casein Kinase-1d inhibitors: a novel strategy for the treatment of frontotemporal dementia". Molecular Neurodegeneration 11 1 (2016): http://dx.doi.org/10.1186/s13024-016-0102-7.
    10.1186/s13024-016-0102-7
  76. Cheng, Yuyan; Pardo, Marta; Armini, Rubia de Souza; Martinez, Ana; Mouhsine, Hadley; Zagury, Jean-Francois; Jope, Richard S.; Beurel, Eleonore. "Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior". Brain, Behavior, and Immunity 53 (2016): 207-222. http://dx.doi.org/10.1016/j.bbi.2015.12.012.
    10.1016/j.bbi.2015.12.012
  77. Mantoani, Susimaire; Chierrito, Talita; Vilela, Adriana; Cardoso, Carmen; Martínez, Ana; Carvalho, Ivone. "Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors". Molecules 21 2 (2016): 193. http://dx.doi.org/10.3390/molecules21020193.
    10.3390/molecules21020193
  78. Di Martino, Rita Maria Concetta; De Simone, Angela; Andrisano, Vincenza; Bisignano, Paola; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; et al. "Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3ß Inhibitors". Journal of Medicinal Chemistry 59 2 (2016): 531-544. http://dx.doi.org/10.1021/acs.jmedchem.5b00894.
    10.1021/acs.jmedchem.5b00894
  79. Prati, Federica; De Simone, Angela; Armirotti, Andrea; Summa, Maria; Pizzirani, Daniela; Scarpelli, Rita; Bertozzi, Sine Mandrup; et al. "3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3ß Fragment Hits against Alzheimer’s Disease". ACS Chemical Neuroscience 6 10 (2015): 1665-1682. http://dx.doi.org/10.1021/acschemneuro.5b00121.
    10.1021/acschemneuro.5b00121
  80. Sastre, Ana; Campillo, Nuria E; Gil, Carmen; Martinez, Ana. "Therapeutic approaches for the future treatment of Fragile X". Current Opinion in Behavioral Sciences 4 (2015): 6-21. http://dx.doi.org/10.1016/j.cobeha.2015.01.003.
    10.1016/j.cobeha.2015.01.003
  81. Muñoz-Sáez, Emma; de Munck García, Estefanía; Arahuetes Portero, Rosa Mª; Martínez, Ana; Solas Alados, Mª Teresa; Miguel, Begoña Gómez. "Analysis of ß-N-methylamino- l -alanine (L-BMAA) neurotoxicity in rat cerebellum". NeuroToxicology 48 (2015): 192-205. http://dx.doi.org/10.1016/j.neuro.2015.04.001.
    10.1016/j.neuro.2015.04.001
  82. Martinez, Ana; Gil, Carmen. "cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases". Expert Opinion on Therapeutic Patents 24 12 (2014): 1311-1321. http://dx.doi.org/10.1517/13543776.2014.968127.
    10.1517/13543776.2014.968127
  83. Salado, Irene G.; Redondo, Miriam; Bello, Murilo L.; Perez, Concepción; Liachko, Nicole F.; Kraemer, Brian C.; Miguel, Laetitia; et al. "Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis". Journal of Medicinal Chemistry 57 6 (2014): 2755-2772. http://dx.doi.org/10.1021/jm500065f.
    10.1021/jm500065f
  84. Morales-Garcia, Jose A.; Palomo, Valle; Redondo, Miriam; Alonso-Gil, Sandra; Gil, Carmen; Martinez, Ana; Perez-Castillo, Ana. "Crosstalk between Phosphodiesterase 7 and Glycogen Synthase Kinase-3: Two Relevant Therapeutic Targets for Neurological Disorders". ACS Chemical Neuroscience 5 3 (2014): 194-204. http://dx.doi.org/10.1021/cn400166d.
    10.1021/cn400166d
  85. de Munck, Estefanía; Muñoz-Sáez, Emma; Miguel, Begoña G.; Solas, M. Teresa; Ojeda, Irene; Martínez, Ana; Gil, Carmen; Arahuetes, Rosa Mª. "ß-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS". Environmental Toxicology and Pharmacology 36 2 (2013): 243-255. http://dx.doi.org/10.1016/j.etap.2013.04.007.
    10.1016/j.etap.2013.04.007

Intellectual property

Patent
  1. Martinez, Ana. 2011. "GSK-3 Alosteric modulators". Spain.
    Granted/Issued
  2. Martinez, Ana. 2009. "5-imino substituted 1,2,4-thiadiazoles useful inthe treatment of neurodegenerative diseases". Spain.
    Granted/Issued
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2018/04 - 2023/04 Inhibidores de TTBK1 como moduladores de TPD-43 para ELA y otras patologias
Supervisor
Medicinal Chemistry/biomedicine (PhD)
2018/10 - 2021/10 Nuevos agentes remielinizantes para la esclerosis multiple
Supervisor
Pharmacology/biomedicine (PhD)
2020/06 - 2021/06 PIKfyve inhibitors for infectious and neurological diseases
Supervisor
Medicinal Chemistry/biomedicine (Master)
2017/04 - 2021/04 Modulación de la proteina TPD-43: Una nueva aproximación terapéutica para ELA
Supervisor
Biology/biomedicine (PhD)
2016/11 - 2020/11 Inhibidores de CDC7 moduladores de TPD-43 útiles en terapias neurológicas
Supervisor
Medicinal chemistry/biomedicine (PhD)
2019/06 - 2020/06 SGK1 inhibitors and mitophagy in ALS
Supervisor
Medicinal Chemistry/biomedicine (Master)
2019/03 - 2020/03 The role of TDP-43 in AD
Supervisor
Biology/biomedicine (Master)