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Bruno Almeida (BA) has a BSc in Applied Biology and a PhD in Health Sciences. For his PhD, BA was awarded the scientific merit prize ¿Prémio Jovem Investigador¿ from the Portuguese Microbiology Society. BA has several competencies in neurodegeneration, structural biology, biochemistry, biophysics, molecular and cell biology, and microbiology. BA conducted research in several top national (ICVS and I3S) and international institutions, such as Leiden University, Oulu University, European Molecular Biology Laboratory, European Synchrotron Radiation Facility, Parc de Recerca Biomèdica de Barcelona and Universitat de Barcelona Centres Científics i Tecnològics. He is an author of 17 papers and 1 book chapter with an accumulated impact factor of 136 and with over 1250 citations conferring an h index of 13. BA was also involved during 6 years in teaching nurse and medical students at the University of Minho. Since graduation, BA has been focusing his attention a) on the molecular mechanisms that dictate cell death and survival, b) the study of host polymorphisms that impact on infection to pathogens, c) the molecular mechanisms controlling neurodegeneration, and d) the development of sensors for the study of neurodegenerative and infectious diseases. Given this specialization path, BA is currently deeply interested in studying disease targets and in the development of diagnostic and therapeutic tools. BA participated in 10 funded research projects, including EU-financed projects, and has 1 international patent application (PCT application in February 2022). As principal investigator, BA secured funding from a pan-European institution (Instruct) with the goal to develop nanobodies functioning as anti-aggregating molecular chaperones with application in neurodegenerative disorders. BA supervised 1 PhD student, 1 MSc student, and 11 BSc students, and co-supervised 2 MSc students. BA contributed to 10 oral presentations (2 as an invited speaker) and 23 poster presentations in national and international conferences. In the last years, BA has been involved in the development of a new generation of diagnostic devices that lead to the creation of IPLEXMED, a spin-off from INL/ICVS-UMinho. BA is currently the CEO of IPLEXMED, which already attracted 500k euros in dilutive and non-dilutive funds, including EIT Health Innostars Grants and awards. IPLEXMED won the 7th Startup Braga Acceleration Program, the pre-acceleration program - Empreender Braga, The Born From Knowledge award from ANI, the prize for the most innovative project of the 1st Hackathon Great Expectations INL-ICVS and the prize for the most disruptive business project in the health sector in the North of Portugal and Galicia (Código+ prize).
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Identification

Personal identification

Full name
Bruno Almeida

Citation names

  • Almeida, Bruno

Author identifiers

Ciência ID
E215-8A55-CF23
ORCID iD
0000-0002-9757-4240

Email addresses

  • brunoalmeida@med.uminho.pt (Professional)
  • brunoalmeida@iplexmed.com (Professional)
  • brunoa1981@gmail.com (Personal)

Telephones

Telephone
  • 253604875 (Professional)
  • 939596852 (Personal)

Addresses

  • Life and Health Sciences Research Institute (ICVS), Universidade do Minho . Campus de Gualtar , 4710-057 , Braga, Braga, Portugal (Professional)
  • Rua do Passal n37, Braga, 4715-591, Braga, Braga, Portugal (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Engineering and Technology - Nano-technology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016/02/01 - 2019/02/13
Concluded
 Regulation of RNA splicing by ATXN3: implications for Machado Joseph Disease (Pós-doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011/02/01 - 2016/02/01
Concluded
 Peptide aptamers as a tool to study Ataxin-3 function in biology and disease (Pós-doutoramento)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010/09/08 - 2010/09/09
Concluded
 Advanced Protein Expression and Crystallization Methods (Postgraduate Certificate)
European Molecular Biology Laboratory, France
2005/02/01 - 2009/06/22
Concluded
 Doutoramento em Ciências da Vida e da Saude (Doutoramento)
Major in Ciências Biológicas e Biomédicas
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death" (THESIS/DISSERTATION)
 Aprovado por unanimidade
2007 - 2007
Concluded
 Bioinformatics (Pós-Graduação)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007
Concluded
 Animal Cell and Tissue Culture: From Basic Principles to Advanced Techniques (Pós-Graduação)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006
Concluded
 Proteomics in life sciences (Pós-Graduação)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2004
Concluded
 Microarrays: principles and applications in medicine (Pós-Graduação)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2004
Concluded
 Fungi relevant in clinical practice: from biology to pathology and treatment (Pós-Graduação)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2004
Concluded
 Biostatistics in health sciences (Pós-Graduação)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
1999/10/04 - 2003/07/01
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho, Portugal
"Industrial yeast strains for high gravity brewing" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/02/01 - Current Contracted Researcher (Research) Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/02/01 - 2019/02/13 Postdoc (Research) Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011/02/01 - 2016/02/01 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/07/08 - 2013/07/15 Visiting Researcher (Research) Parc de Recerca Biomèdica de Barcelona, Spain
Parc de Recerca Biomèdica de Barcelona, Spain
2011/09/05 - 2011/09/20 Visiting Researcher (Research) Universitat de Barcelona Centres Científics i Tecnològics, Spain
Universitat de Barcelona Centres Científics i Tecnològics, Spain
2011/05/01 - 2011/05/30 Visiting Researcher (Research) European Molecular Biology Laboratory, France
European Molecular Biology Laboratory, France
2005/03/01 - 2005/07/30 Visiting Researcher (Research) Oulun yliopisto Biokemian ja molekyylilaaketieteen tiedekunta, Finland
Oulun yliopisto Biokemian ja molekyylilaaketieteen tiedekunta, Finland
2004/02/01 - 2005/02/01 Research Trainee (Research) Universidade do Minho, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2003/03/03 - 2003/07/30 Research Trainee (Research) Universiteit Leiden Instituut Biologie Leiden, Netherlands
Universiteit Leiden Instituut Biologie Leiden, Netherlands

Teaching in Higher Education

Category
Host institution 		Employer
2009/05/01 - 2010/02/01 Invited Assistant Professor (University Teacher) Universidade do Minho, Portugal
Universidade do Minho Escola de Medicina, Portugal
2004/10/01 - 2009/01/01 Tutor (University Teacher) Universidade do Minho, Portugal
Universidade do Minho Escola de Medicina, Portugal

Others

Category
Host institution 		Employer
2021/09/14 - Current CEO IPLEXMED, Lda, Portugal
IPLEXMED, Lda, Portugal
Projects

Grant

Designation Funders
2016/02/01 - 2019/02/13 Regulation of RNA splicing by ATXN3: implications for Machado Joseph Disease
SFRH/BPD/110728/2015
Post-doc Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/02/01 - 2016/02/28 Peptide aptamers as a tool to study Ataxin-3 function in Biology and Disease
SFRH/BPD/70783/2010
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/02/01 - 2009/06/23 Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death
SFRH/BD/15317/2005
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/04/01 - Current A point-of-care device for non-invasive multiplexed diagnosis of malaria
MULTIMAL
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

International Iberian Nanotechnology Laboratory, Portugal
European Organization for Nuclear Research
Ongoing
2019/01/01 - Current Nuclear ataxin-3 protein-protein interactions as therapeutic targets in Machado-Joseph disease
POCI-01-0145-FEDER-029056
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/05/01 - 2022/12/30 Graphresp - A point-of-care and at-home digital device for non-invasive multiplexed diagnosis of clinical and resistant respiratory infections
Graphresp EIT
Principal investigator
IPLEXMED, Lda, Portugal
 EIT Health
Ongoing
2017/09/01 - 2018/08/30 MULTIMAL
MULTIMAL
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde

International Iberian Nanotechnology Laboratory
Concluded
2013/07/01 - 2015/12 Ambiguity and virulence in a human pathogen
PTDC/BBB-BEP/0695/2012
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/09 - 2015/09 Structural characterization of Ataxin-3: development of anti-aggregation molecules and crystallization chaperones
RID-47
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Instruct - Integrating Structural Biology
Concluded
2013/07/01 - 2015/06/30 Biochemical and structural characterization of gene regulation by IscR, the Fe-S cluster biogenesis pathway regulator
PTDC/BBB-BEP/2127/2012
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 A peptide aptamer-based approach to neurodegenerative disorders
PTDC/BIA-PRO/100059/2008
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2012/12/31 DIOMED - Cooperação transnacional para a innovação tecnológica no desenvolvimento de moléculas para o tratamento da obesidade e diabetes
SOE1/P1/E178
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Regional Development Fund
Concluded
2005/01/01 - 2008/12/31 Saccharomyces cerevisiae: padrão proteómico e interacções com a metacaspase
POCTI/BIA-BCM/57364/2004
Researcher
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003/03/01 - 2003/07/30 Stress-tolerant Industrial Yeast Strains for High-Gravity Brewing
Ref: QLK1-CT-2001-01066
Other
Universiteit Leiden Instituut Biologie Leiden, Netherlands
 Community Research and Development Information Programme
Concluded
Outputs

Publications

Book chapter
  1. Almeida, Bruno. "Protein misfolding and cell death". In Protein Misfolding in Biology and Disease. 2008.
    Published
Conference paper
  1. Neves-Carvalho, A; Duarte-Silva, S; Silva, J; Almeida, Bruno; Heeltveld, S; Sotiropoulos, I; Wan Li, K; Heutink, P; Maciel, Patrícia. "Neuronal missplicing and imbalance in tau isoform ratio through atxn3 mediated deubiquitylation: implications for disease". Paper presented in AAIC 2019, 2019.
  2. Mesquita, A.; Silva, Alexandra; Sampaio-Marques, B.; Almeida, Bruno; Logarinho, Elsa; Leão C; Rodrigues F; Ludovico P. "Oxidative stress during chronological life span in Saccharomyces cerevisiae". Paper presented in MicroBiotec 09, 2009.
    Published
  3. Almeida, Bruno; Buttner S; Ohlmeier S; Silva, Alexandra; Mesquita, A.; Sampaio-Marques, B.; Osório, Nuno S.; et al. "Evidence for NO-mediated apoptosis in yeast". 2007.
    10.1002/yea.1528
Conference poster
  1. Neves-Carvalho, Andreia; Duarte-Silva, S; Almeida, Bruno; Heetveld S; Sotiropoulos I; Heutink P; Wan KL; Maciel, Patrícia. "Regulation of neuronal mRNA splicing and Tau isoform by ATXN3 in Spinocerebellar Ataxia Type-3 transgenic mice and patients.". Paper presented in VIII National RNA Meeting: ptRNA2019, 2019.
  2. Almeida, Bruno; Neves-Carvalho, Andreia; Macedo-Ribeiro, Sandra; Maciel, Patrícia. "Macromolecular interactions and posttranslational modifications acting as Machado-Joseph Disease modifiers". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, 2017.
  3. Almeida, Bruno; Abreu IA; Matos CA; Fraga, J.; Fernandes, Sara; Macedo MG; Gutiérrez-Gallego, R.; et al. "SUMOylation of the brain-predominant ataxin-3 isoform regulates VCP/p97-mediated inhibition of amyloid fiber formation". Paper presented in Instruct Biennial Structural Biology Meeting 2015, 2015.
  4. Scarff CA; Sicorello A; Fraga, J; Almeida, Bruno; Tomé RJL; Macedo-Ribeiro, Sandra; Radford SE; Ashcroft AE. "Probing the Aggregation and Conformational Properties of the PolyQ Protein Ataxin-3". Paper presented in FASEB meeting – Molecular mechanisms and physiological consequences of protein aggregation 2013, 2013.
  5. Fernandes Sara; Abreu IA; Almeida, Bruno; Fraga, J; Pereira PJB; Macedo-Ribeiro, Sandra. "Machado Joseph Disease-causative protein Ataxin-3 is SUMOylated". Paper presented in 22nd IUBMB – 37th FEBS meeting, 2012.
  6. Almeida, Bruno; Fernandes Sara; Abreu, I.A.; Fraga, J; Pereira PJB; Macedo-Ribeiro, Sandra. "Ataxin-3:p97/VCP interaction: a route for Ataxin-3 three-dimensional structure determination". Paper presented in 4th AIM – Ataxia Investigators Meeting 2012, 2012.
  7. Louro J; Simões M; Almeida, Bruno; Faro C; Pereira PJB; Macedo-Ribeiro, Sandra; Castanheira P. "E. coli expression and purification of human Mitofusin-2 GTPase domain". Paper presented in 7th Annual PEGS Summit, 2011.
  8. Simões M; Louro J; Almeida, Bruno; Faro C; Pereira PJB; Castanheira P; Macedo-Ribeiro, Sandra. "Expression and purification of human DOR". Paper presented in XVIIth National Congress of Biochemistry, 2010.
  9. Louro J; Simões M; Almeida, Bruno; Faro C; Pereira PJB; Castanheira P; Macedo-Ribeiro, Sandra. "Expression and purification of human Mitofusin-2 GTPase domain". Paper presented in XVIIth National Congress of Biochemistry, 2010.
  10. Almeida, Bruno; Pereira PJB; Macedo-Ribeiro, Sandra. "Validation and purification of Ataxin-3 – VCP and Ataxin-3 – Rad23 complexes: a route for Ataxin-3 structure determination". Paper presented in 1st P-CUBE meeting, 2010.
  11. Azevedo MM; Almeida, Bruno; LUDOVICO, PAULA; Cassio, Fernanda. "Metal stress induces programmed cell death in aquatic fungi". Paper presented in SETAC Europe 19th Annual Meeting, 2009.
  12. Almeida, Bruno; Sampaio-Marques, B.; Silva, Alexandra; Ludovico P. "Deletion of HBN1 results in yeast aberrant mitochondrial morphology and chronological life span extension". Paper presented in International Symposium on Mitochondrial Physiology and Pathology IUBMB Symposium, 2008.
  13. Almeida, Bruno; Ohlmeier S; Gourlay C; Leão C; Madeo F; Rodrigues F; LUDOVICO, PAULA. "Involvement of eEF1A in acetic acid-induced apoptosis in yeast". Paper presented in 6th IMYA – International Meeting on Yeast Apoptosis, 2008.
  14. Almeida, Bruno; Silva Alexandra; Leao C; Rodrigues F; Ludovico P. "HBN1 null cells exhibits extended chronological life span". Paper presented in 6th IMYA – International Meeting on Yeast Apoptosis, 2008.
  15. Almeida, Bruno; Silva, Alexandra; Mesquita, A.; Sampaio-Marques, B.; Leão C; Rodrigues F; Ludovico P. "Glyceraldehyde-3-phosphate dehydrogenase as a crucial mediator of Saccharomyces cerevisiae apoptotic cell death". Paper presented in 6th IMYA – International Meeting on Yeast Apoptosis, 2008.
  16. Mesquita, A.; Almeida, Bruno; Silva, Alexandra; Leão C; Rodrigues F; Ludovico P. "Glycolytic oscillations and stress response in Saccharomyces cerevisiae". Paper presented in SMYTE - 25th Small Meeting on Yeast Transport and Energetic, 2007.
  17. Almeida, Bruno; Buttner S; Ohlmeier S; Silva, Alexandra; Mesquita, A.; Sampaio-Marques, B.; Osório, Nuno S.; et al. "Evidence for NO-mediated apoptosis in yeast". Paper presented in XXIIIrd International Conference on Yeast Genetics and Molecular Biology, 2007.
  18. Almeida, Bruno; Ohlmeier S; Almeida Ines; Leão C; Rodrigues F; Ludovico P. "Saccharomyces cerevisiae translation factors are regulating actin cytoskeleton during acetic-acid-induced apoptosis in yeast". Paper presented in XVth National Congress of Biochemistry, 2006.
  19. Almeida, Bruno; Ohlmeier S; Almeida Ines; Leão C; Rodrigues F; Ludovico P. "Involvement of yeast translation machinery in response to acetic acid stress". Paper presented in Translational Control and Non-Coding RNA Meeting, 2006.
  20. Almeida, Bruno; Ohlmeier S; Almeida Ines; Gourlay CW; Leão C; Rodrigues F; Ludovico P. "Saccharomyces cerevisiae eEF1A regulates actin cytoskeleton during acetic acid-induced apoptosis". Paper presented in XLIth Congress of the Portuguese Society for Microscopy, 2006.
  21. Almeida, Bruno; Osório, Nuno S.; Ohlmeier S; Pearce DA; Rodrigues F; Ludovico P. "Uncovering Saccharomyces cerevisiae active cell death pathways: oxidative versus acid stress". Paper presented in Metabolomics: From Bioenergetics to Apoptosis, Keystone Symposia, 2006.
  22. Almeida, Bruno; Ohlmeier S; Ludovico P. "Insights on Acetic Acid- and Hydrogen Peroxide-induced apoptosis in Saccharomyces cerevisiae: A proteomic comparison". Paper presented in 4th IMYA - International Meeting on Yeast Apoptosis, 2005.
  23. Almeida, Bruno; Carvalho, J.; Ludovico P. "Cell Death Induced by Antifungal Drugs in Saccharomyces cerevisiae". Paper presented in 3rd IMYA - International Meeting on Yeast Apoptosis, 2004.
Journal article
  1. Francisco Figueiredo; Mónica Lopes-Marques; Bruno Almeida; Nena Matscheko; Pedro M. Martins; Alexandra Silva; Sandra Macedo-Ribeiro. "A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly". Cells 11 12 (2022): 1969-1969. https://doi.org/10.3390/cells11121969.
    10.3390/cells11121969
  2. Da Silva, Jorge Diogo; Costa, Marta Daniela; Almeida, Bruno; Lopes, Fátima; Maciel, Patrícia; Teixeira-Castro, Andreia. "Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders". Frontiers in Neurology 12 (2021): http://dx.doi.org/10.3389/fneur.2021.735549.
    10.3389/fneur.2021.735549
  3. Andreia Neves-Carvalho; Sara Duarte-Silva; Beatriz Rodrigues; Joana Silva; Sasja Heetveld; Almeida, Bruno; Natalia Savytska; et al. "Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors". The EMBO Journal (2020): https://doi.org/10.1101/711424.
    Submitted • https://doi.org/10.1101/711424
  4. Silva, A.; Almeida, B.; Fraga, J.S.; Taboada, P.; Martins, P.M.; Macedo-Ribeiro, S.. "Distribution of Amyloid-Like and Oligomeric Species from Protein Aggregation Kinetics". Angewandte Chemie - International Edition 56 45 (2017): 14042-14045. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032264546&partnerID=MN8TOARS.
    10.1002/anie.201707345
  5. Matos, C.A.; Nóbrega, C.; Louros, S.R.; Almeida, B.; Ferreiro, E.; Valero, J.; De Almeida, L.P.; Macedo-Ribeiro, S.; Carvalho, A.L.. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models". Journal of Cell Biology 212 4 (2016): 465-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959536774&partnerID=MN8TOARS.
    10.1083/jcb.201506025
  6. Scarff, C.A.; Almeida, B.; Fraga, J.; Macedo-Ribeiro, S.; Radford, S.E.; Ashcroft, A.E.. "Examination of ataxin-3 (atx-3) aggregation by structural mass spectrometry techniques: A rationale for expedited aggregation upon polyglutamine (polyQ) expansion". Molecular and Cellular Proteomics 14 5 (2015): 1241-1253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929657616&partnerID=MN8TOARS.
    10.1074/mcp.M114.044610
  7. Almeida, B.; Abreu, I.A.; Matos, C.A.; Fraga, J.S.; Fernandes, S.; Macedo, M.G.; Gutiérrez-Gallego, R.; et al. "SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 9 (2015): 1950-1959. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955513053&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.06.010
  8. Cunha, C.; Aversa, F.; Lacerda, J.F.; Busca, A.; Kurzai, O.; Grube, M.; Löffler, J.; et al. "Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation". New England Journal of Medicine 370 5 (2014): 421-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893065011&partnerID=MN8TOARS.
    10.1056/NEJMoa1211161
  9. Almeida, B.; Fernandes, S.; Abreu, I.A.; Macedo-Ribeiro, S.. "Trinucleotide repeats: A structural perspective". Frontiers in Neurology 4 JUN (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883533687&partnerID=MN8TOARS.
    10.3389/fneur.2013.00076
  10. Silva, A.; Almeida, B.; Sampaio-Marques, B.; Reis, M.I.R.; Ohlmeier, S.; Rodrigues, F.; Vale, A.D.; Ludovico, P.. "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a specific substrate of yeast metacaspase". Biochimica et Biophysica Acta - Molecular Cell Research 1813 12 (2011): 2044-2049. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054096814&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2011.09.010
  11. Garriga, D.; Vives-Adrián, L.; Buxaderas, M.; Ferreira-Da-Silva, F.; Almeida, B.; MacEdo-Ribeiro, S.; Pereira, P.J.B.; Verdaguer, N.. "Cloning, purification and preliminary crystallographic studies of the 2AB protein from hepatitis A virus". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 10 (2011): 1224-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955155458&partnerID=MN8TOARS.
    10.1107/S1744309111026261
  12. Mesquita, A.; Weinberger, M.; Silva, A.; Sampaio-Marques, B.; Almeida, B.; Leão, C.; Costa, V.; et al. "Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity". Proceedings of the National Academy of Sciences of the United States of America 107 34 (2010): 15123-15128. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956987110&partnerID=MN8TOARS.
    10.1073/pnas.1004432107
  13. Azevedo, M.-M.; Almeida, B.; Ludovico, P.; Cássio, F.. "Metal stress induces programmed cell death in aquatic fungi". Aquatic Toxicology 92 4 (2009): 264-270. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349193571&partnerID=MN8TOARS.
    10.1016/j.aquatox.2009.02.010
  14. Almeida, B.; Ohlmeier, S.; Almeida, A.J.; Madeo, F.; Leão, C.; Rodrigues, F.; Ludovico, P.. "Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway". Proteomics 9 3 (2009): 720-732. http://www.scopus.com/inward/record.url?eid=2-s2.0-60549114895&partnerID=MN8TOARS.
    10.1002/pmic.200700816
  15. Almeida, T.; Marques, M.; Mojzita, D.; Amorim, M.A.; Silva, R.D.; Almeida, B.; Rodrigues, P.; et al. "Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis". Molecular Biology of the Cell 19 3 (2008): 865-876. http://www.scopus.com/inward/record.url?eid=2-s2.0-41649101223&partnerID=MN8TOARS.
    10.1091/mbc.E07-06-0604
  16. Almeida, B.; Silva, A.; Mesquita, A.; Sampaio-Marques, B.; Rodrigues, F.; Ludovico, P.. "Drug-induced apoptosis in yeast". Biochimica et Biophysica Acta - Molecular Cell Research 1783 7 (2008): 1436-1448. http://www.scopus.com/inward/record.url?eid=2-s2.0-46549088859&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.01.005
  17. Almeida, B.; Buttner, S.; Ohlmeier, S.; Silva, A.; Mesquita, A.; Sampaio-Marques, B.; Osório, N.S.; et al. "NO-mediated apoptosis in yeast". Journal of Cell Science 120 18 (2007): 3279-3288. http://www.scopus.com/inward/record.url?eid=2-s2.0-35548961293&partnerID=MN8TOARS.
    10.1242/jcs.010926
  18. Almeida, B.; Sampaio-Marques, B.; Carvalho, J.; Silva, M.T.; Leão, C.; Rodrigues, F.; Ludovico, P.. "An atypical active cell death process underlies the fungicidal activity of ciclopirox olamine against the yeast Saccharomyces cerevisiae". FEMS Yeast Research 7 3 (2007): 404-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147118520&partnerID=MN8TOARS.
    10.1111/j.1567-1364.2006.00188.x
Thesis / Dissertation
  1. Almeida, Bruno. "Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death". PhD, 2009.

Intellectual property

Provisional application for patent
  1. 2021. "GRAPHENE-BASED MALARIA SENSOR, METHODS AND USES THEREOF - nº117090".
    Protected

Other

Spin-off company
  1. 2021. IPLEXMED, Lda. MedTech. www.iplexmed.com.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11/24 From Lab to Market - Innovation Challenges and Opportunities in Health and Life Sciences 2nd Global StartupCities Summit 2021 - Málaga
(Málaga, Spain)
2016/11/11 Protein interaction analysis by Surface Plasmon Resonance EMBO Practical Course - Biomolecular interaction analysis 2016: From molecules to cells
EMBO (Porto, Portugal)
2016/07/11 Structural analysis of challenging targets: hybrid methods and more 2nd PCISBIO day
Portuguese Center For Integrated Structural Biology (Oeiras, Portugal)
2014/11/28 Protein interaction analysis by Surface Plasmon Resonance EMBO Practical Course - Biomolecular interactions analysis 2014: From molecules to cells
EMBO
2012/11/13 Baculovirus-assisted eukaryotic protein expression Course on Biomolecular Interaction Analysis 2012
IBMC
2009/06/19 Elucidation of molecular pathways involved in Saccharomyces cerevisiae apoptotic cell death XVII Jornadas de Biologia de Leveduras
Sociedade Portuguesa de Microbiologia
2007/07/02 Evidence for NO-mediated apoptosis in yeast XXIIIrd International Conference on Yeast Genetics and Molecular Biology
(Melbourne, Australia)
2007/06/16 Oscilações glicolíticas e resposta ao stresse em Saccharomyces cerevisiae XV Jornadas de Biologia de Leveduras "Professor Nicolau van Uden"
(Porto, Portugal)
2007/06/15 O óxido nítrico é um mediador do processo de morte celular programada da levedura Saccharomyces cerevisiae XV Jornadas de Biologia de Leveduras "Professor Nicolau van Uden"
(Porto, Portugal)
2006/11/05 Requirement of the TOR pathway for acetic acid induced apoptosis in yeast 5th International Meeting on Yeast Apoptosis
(Kutná Hora, Czech Republic)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/03/01 - Current Development of a cellular ataxin-3 protein-protein interaction (PPI) assay for high-throughput screening of PPI modifiers
Supervisor of Ana Rita Ferreira Fernandes
 Mestrado em Ciências da Saúde (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/01/01 - Current Nuclear ATXN3 DUB physiological substrates: towards understanding their role in the context of Machado-Joseph Disease (Ref: SFRH/BD/145648/2019)
Supervisor of Liliana Sofia Meireles da Costa
 Doutoramento em Ciências da Saúde (PhD)
Universidade do Minho, Portugal
2021/03/01 - 2021/08/31 Development of a protein-protein interaction assay for screening of Machado-Joseph Disease modifiers
Supervisor of Ana Rita Silva Reis Dourado
 Biologia Aplicada (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/03/01 - 2021/08/31 Characterization of ataxin-3 nuclear interactors: towards understanding their role in the context of Machado-Joseph Disease
Supervisor of João Gonçalo Ereira da Silva
 Biologia Aplicada (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020/04/28 - 2020/12/01 Characterization of ATXN3 physiological substrates: implications for Machado Joseph Disease
Supervisor of Ana Rita Ferreira Fernandes
Licenciatura em Bioquímica (Degree)
Universidade do Minho, Portugal
2019/04/01 - 2019/07/30 Estudo da relevância fisiológica da interação Ataxina-3:HSP60 em células neuronais
Supervisor of Ana Catarina Coutinho Vilaça Ferreira
 Licenciatura em Bioquímica (Degree)
Universidade do Minho, Portugal
2017/04/01 - 2017/07/30 Influência da atividade DUB da ataxina-3 na desregulação de splicing de RNA: implicações para a doença de Machado-Joseph
Supervisor of António Rafael Marques Nogueira
 Licenciatura em Bioquímica (Degree)
Universidade do Minho, Portugal
2017/04/01 - 2017/04/30 Impact of RNA splicing deregulation for Machado Joseph Disease
Supervisor of Miguel Gil Afonso Santejo
 Licenciatura em Bioquímica (Degree)
Universidade do Minho, Portugal
2013/01/01 - 2013/07/31 Crystallization of new therapeutic targets
Supervisor of Fernando Vilela
 Licenciatura em Bioquímica (Degree)
Universidade do Porto, Portugal
2013/01/01 - 2013/07/31 Cloning, expression and purification of Ataxin-3 molecular interactors
Supervisor of Diogo Silva
 Biotecnologia (Degree)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2012/01/01 - 2012/12/31 Structural characterization of proteins associated to autophagy
Supervisor of Marisa Simões
 Mestrado em Biologia Molecular e Celular (Master)
Universidade de Aveiro, Portugal
2008/01/01 - 2008/12/31 The role of yeast aconitase, Aco1p, in oxidative stress-induced apoptosis
Co-supervisor of Helena da Costa Marques
 Biologia Molecular e Ambiental (Master)
Universidade do Minho, Portugal
2007/09/01 - 2007/10/31 Autophagic cell death in a yeast model for Machado-Joseph disease
Supervisor of Márcio Samuel da Cunha Rodrigues
Medicina (Degree)
Universidade do Minho Escola de Medicina, Portugal
2006/09/01 - 2006/10/30 The yeast Saccharomyces cerevisiae as a cellular and molecular eukaryotic model
Supervisor of Ana Raquel Franky Gomes Carvalho
 Medicina (Degree)
Universidade do Minho Escola de Medicina, Portugal
2006/02/01 - 2006/09/30 Yeast models of Parkinson, Huntington and Machado Joseph diseases
Co-supervisor of Carla Patrícia Guimarães de Sousa
 Licenciatura em Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/11/07 - 2016/11/11 Participation in the organization of the EMBO Practical Course "Biomolecular interactions analysis: From molecules to cells” (2016/11/07 - 2016/11/11)
Workshop (Member of the Organising Committee)
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2014/11/24 - 2014/11/28 Participation in the organization of the EMBO Practical Course "Biomolecular interactions analysis: From molecules to cells” (2014/11/24 - 2014/11/28)
Workshop (Member of the Organising Committee)
 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/10/02 - 2006/10/08 Participation in the organization of the postgradutation course "“Proteomics in life sciences” (2006/10/02 - 2006/10/08)
Workshop (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004/09/01 - 2004/09/07 Participation in the organization of the postgradutation course "Fungi relevant in clinical practice: from biology to pathology and treatment” (2004/09/01 - 2004/09/07)
Other (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/03/16 - 2022/03/16 From the lab to a medtech startup Being a Bio-entrepreneur (Pós-Graduação) Universidade do Minho, Portugal
2017/11/05 - 2020/11/09 Notions about proteomics and applications Postgraduation course of Bioinformatics (Pós-Graduação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/06/03 - 2015/05/07 Structural Biology Graduate Program in Areas of Basic and Aplied Biology (GABBA) (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2009/05/01 - 2010/02/01 Responsible for pratical classes of Molecules and Cells from the Medicine Course of the University of Minho Medicina (Licenciatura) Universidade do Minho Escola de Medicina, Portugal
2006/10/01 - 2009/01/01 Responsible for the pratical classes of Cellular and Molecular Biology from the Nursing course of the University of Minho Enfermagem (Licenciatura) Universidade do Minho, Portugal
2004/10/01 - 2009/01/01 Responsible for the pratical classes of Molecules and Cells from the Medicine course of the University of Minho Medicina (Licenciatura) Universidade do Minho, Portugal
2005/10/01 - 2006/01/01 Responsible for the pratical classes of Biochemistry and Biophysics from the Nursing Course of the University of Minho Enfermagem (Licenciatura) Universidade do Minho, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021/12/08 Interview about the activities of IPLEXMED JN
2021/10/01 An opinion article about digitalization in health care. SPOT magazine. SPOT
Distinctions

Award

2022 Winner of 7th Acceleration Program
Startup Braga, Portugal
2021 Winner of Empreender Braga
Startup Braga, Portugal
2020 Winner of Código+ Project Prize
2019 Best Poster award of the VIII National RNA Meeting: ptRNA2019
2017 Winner of the 1st INL-ICVS Hackathon
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

International Iberian Nanotechnology Laboratory, Portugal
2009 Prémio Jovem Investigador "Professora Isabel Spencer Martins"
Sociedade Portuguesa de Microbiologia, Portugal
2007 Meeting attendance grant
Federation Of European Microbiological Societies, United Kingdom