???global.info.a_carregar???
Identification

Personal identification

Full name
PEDRO JORGE GOMES TEODÓSIO CASTELO BRANCO

Citation names

  • Branco, Pedro
  • Pedro Castelo-Branco
  • Pedro Castelo Branco

Author identifiers

Ciência ID
E015-7F8F-5CA1
ORCID iD
0000-0002-3453-3978
Google Scholar ID
https://scholar.google.pt/citations?user=oEnd7XMAAAAJ&hl=pt-PT&oi=ao
Education
Degree Classification
2022/10/24 - 2022/10/25
Concluded
 Ciências Biomédicas (Habilitation (Aggregation Title))
Universidade do Algarve, Portugal
2020
Concluded
 Habilitation in biology (Scientific Coordination Accreditation Title)
Sorbonne Université, France
2000 - 2005
Concluded
 Oxford (Doctorate)
University of Oxford Sir William Dunn School of Pathology, United Kingdom
"Polypyrimidine Tract Binding Protein (PTB) Regulates mRNA 3' End Formation in Mammals" (THESIS/DISSERTATION)
1993 - 1998
Concluded
 Biologia (Licenciate Degree)
Universidade de Aveiro, Portugal
Affiliation

Science

Category
Host institution		 Employer
2008/11 - 2014/02 Postdoc (Research) University of Toronto - Mississauga, Canada
Hospital for Sick Children, Canada
2006/02 - 2008/07 Postdoc (Research) Massachusetts General Hospital, United States
Harvard Medical School, United States
1999/03 - 2000/10 Research Trainee (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1998/12 - 1999/03 Research Trainee (Research) Instituto Português do Desporto e Juventude, Portugal
1997/10 - 1998/03 Research Trainee (Research) Université de Tours, France

Teaching in Higher Education

Category
Host institution		 Employer
2022/02/01 - Current Associate Professor (University Teacher) Universidade do Algarve - Campus de Gambelas, Portugal
2014 - 2019 Assistant Professor (University Teacher) Universidade do Algarve, Portugal

Positions / Appointments

Category
Host institution		 Employer
2026 - Current Vice-Rector Universidade do Algarve, Portugal
2014 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2022/12/06 - 2025/12 President Algarve Biomedical Center, Portugal
2019/09 - 2021/01/15 President Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2015 - 2019 Conselho científico/técnico-científico ou orgão correspondente Universidade do Algarve, Portugal
Projects

Grant

Designation Funders
2019 - 2024 EpiGen Marks for Human Sepsis
Project Grant Spring 2019
Researcher
Canadian Institutes of Health Research, Canada
 Canadian Institutes of Health Research
2022/01 - 2023/01 Epigenetic signatures of schizophrenia in an IPS derived model during neuronal differentiation
ABC-RI exploratory grants
 Algarve Biomedical Center Research Institute
2015 - 2020 Targeting the telomere maintenance pathway for cancer diagnostics and therapeutics.
Researcher
Canadian Cancer Society, Canada
2015 - 2020 Novel implications of THOR hypermethylation in telomere maintenance and gliomagenesis.
Researcher
2018 - 2019 Xenografting of bovine ovarian tissue as a model for testing new drugs and examining angiogenesis, follicle premature depletion and dynamics
Researcher
2016 - 2018 The role of telomere maintenance in urologic maligancies.
Supervisor
2015 - 2018 The diagnostic, prognostic and therapeutic role of THOR in breast cancer.
Supervisor
2015/01 - 2017/01 Diagnostic, prognostic and therapeutic implications of THOR - Tert Hypermethylated Oncologic Region in breast cancer | 25k
Maratona da Saúde
Principal investigator
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2017 Uncovering novel therapeutic targets that regulate the self-renewal capacity of colorectal cancer.
Supervisor
2015 - 2017 Utilization of THOR hypermethylation for stratification and noninvasive detection of cancer
Researcher
2015 - 2016 McLaughlin Centre Accelerator Grants in Genomic Medicine and Health Informatics. Epigenetic Profiling in Severe Sepsis (EPSIS).
Genomic Medicine and Health Informatics
Researcher
2015 - 2016 Epigenetic Profiling in Severe Sepsis (EPSIS).
Researcher
2015 - 2016 miRNAs marcadores séricos de doença testicular ativa
Bolsa de Investigação APU/Tecnimede
Researcher
University of Toronto, Canada
2010 - 2015 Prediction and Prevention of glioma recurrence by targeting telomere dependent self-renewal capacity of tumor initiating cells.
Other
2012 - 2014 O papel da leptina no microambiente e oncogenese do carcinoma da prostata.
Researcher
2011 - 2013 O efeito de terapeuticas usadas no carcinoma da prostata na subpopulação de células estaminais cancerosas prostáticas
PTDC/BIM-ONC/0377/2012
Researcher
2010 - 2013 Exhaustion of tumor initiating cells by targeting their self-renewal capacity with telomerase inhibition
Terry Fox New Investigator Award
Other
2012 - 2012 hTERT methylation as a diagnostic and predictive tool for various tumors.
Other
2001/03/01 - 2005/02/28 ESTUDO DE PROTEÍNAS REGULADORAS DA FORMAÇÃO DO TERMINAL 3 DE mRNAs
SFRH/BD/1426/2000
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/10 - Current Algarve Fit Ageing Score: a new integrative tool for quality of life improvement and healthy Ageing (ALFASCORE) | 860k
ALG-01-0145-FEDER-072586
Principal investigator
Ongoing
2023/02/01 - 2026/01/31 Epigenetics modifications in the mare endometrium: Implications on fibrosis pathogenesis in endometrosis
2022.09161.PTDC
10.54499/2022.09161.PTDC
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2025/12/31 Algarve Biomedical Center (ABC)
CAC/0007/2022
10.54499/CAC/0007/2022
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/06/30 Decoding breast cancer evolution through mutant allele differential expression signatures
PTDC/MED-ONC/31477/2017
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2020/03/31 Centre for Biomedical Research
UID/BIM/04773/2019
Universidade do Algarve, Portugal

Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Castelo-Branco, P.; Jeronimo, C.. Histone Modifications in Therapy. 2020.
    10.1016/B978-0-12-816422-8.09995-5
  2. Castelo-Branco, P.; Jerónimo, C.. Preface. 2020.
Book chapter
  1. Pedro Castelo-Branco. "Histone modifications in diseases". In Histone Modification in Therapy, 1-15. Elsevier Translation Epigenetics Series, 2020.
  2. Fernandes, M.T.; Almeida-Lousada, H.; Castelo-Branco, P.. "Histone modifications in diseases". 1-15. 2020.
  3. Pedro Castelo-Branco. "Gastric Cancer". In International Manual of Oncology Practice, 303-330. 2019.
  4. Castelo-Branco, L.; Oualla, K.; Castelo-Branco, P.; Mello, R.A.D.. "Gastric Cancer". 303-330. 2019.
  5. Pedro Castelo-Branco. "What we will expect from novel therapies to Esophageal and Gastric malignancies". In American Society of Clinical Oncology Educational Book, 249-261. 2018.
Conference abstract
  1. Cardoso, Candida; Pestana, Daniel; Ramalhete, Sara; Mestre, André; MARREIROS, ANA; Fernandes, Mónica T; Pedro Castelo-Branco. "Prognostic Markers in Intermediate Patients with Acute Myeloid Leukemia". Paper presented in Acute Myeloid Leukemia”. Poster apresentado em 3as, Albufeira, 2019.
    Published
  2. Pestana, Daniel; Cardoso, Candida; Mestre, André; Ramalhete, Sara; MARREIROS, ANA; Mónica Teotónio Fernandes; Pedro Castelo-Branco. "Epi-Hotspots in cancer initiation". Paper presented in 3as Jornadas do Algarve Biomedical Center, Albufeira, 2019.
    Published
Conference poster
  1. Rajado, Ana Teresa; Estevam, Bernardo; Costa, Rafael G; Vásquez-Mojena, Yaimée; Zamora Fung, Rolando ; Pupo Marrero, Claudia ; Jaime López, Leydis ; et al. "From Code to Chromatin: Using AI and Epigenetics to Identify SCA2 Biomarkers". Paper presented in 5th Workshop on Neuroengineering: AI tools in Neuroscience, 2025.
  2. Pestana, Daniel; Cardoso, Candida; Ramos, Mónica; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Nóbrega, Clévio David Rodrigues ; Justin O'Sullivan; Pedro Castelo-Branco. Corresponding author: Pestana, Daniel. "Ageing Well in Algarve: A Clinical, Molecular and Geospatial integrative analysis into Elderly Health and fitness". Paper presented in Encontro Ciência 2025, 2025.
  3. Paiva-Correia, António; Apolónio, Joana ; Pedro Castelo-Branco; Henrik Hellquist. "Salivary gland tumours are epigenetically regulated by THOR methylation.". Paper presented in 36th European Congress of Pathology, 7 - 11 September 2024 | Florence, Italy, 2024.
  4. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Rajado, Ana Teresa; Nóbrega, Clévio David Rodrigues ; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. Corresponding author: Araújo, Inês Maria. "Oxidative profile of a cohort of young versus aged individuals in the Algarve region". Paper presented in HEAT-NET Frontiers in Neurodegeneration: from bench to bedside, 2024.
  5. Ramos, Mónica; Santos, Daniela F.; Rajado, Ana Teresa; ALFA Score Consortium; Silva, Nádia; Araújo, Inês; Pedro Castelo-Branco. Corresponding author: Pedro Castelo-Branco. "Associations between a DNA methylation-based telomere length estimator, the redox state, diet and aging in the Algarve population". Paper presented in IX Clinical Biochemistry Workshop, 2024.
  6. Fernandes, Mónica T.; Apolónio, Joana ; Esteves, Filipa; De Sousa-Coelho, Ana Luísa; Sofia M. Calado; Marreiros, Ana; Pedro Castelo-Branco. "Unveiling a novel epigenetic biomarker for personalized medicine in gliomas". Paper presented in Congresso Nacional dos Farmacêuticos, CNF24: Mais Inovação, Melhor Saúde, 2024.
  7. Matos, José; Silva, Nádia; Trindade, Marlene; Rajado, Ana Teresa; Pedro Castelo-Branco; Faleiro, Maria Leonor. "GUT BACTERIAL METATAXONOMIC ANALYSIS OF ELDERLY FROM ALGARVE". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023.
  8. Mónica Alexandra Teotónio Fernandes; Apolónio, Joana ; De Sousa-Coelho, Ana Luísa; MARREIROS, ANA; Pedro Castelo-Branco; Bragança, José. "CITED4 methylation is a novel prognosis biomarker in gliomas". Paper presented in EACR-AstraZenecaCancer Epigenetics Virtual Event, Worldwide. ONLINE, 2023.
  9. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Brito, David V.C.; Clévio Nobrega; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. "Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region.". Paper presented in 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023.
  10. Rajado, Ana Teresa; Pestana, Daniel; Silva, Nádia; Apolónio, Joana ; Esteves, Filipa; Brito, David V.C.; Trindade, Marlene; et al. "Algarve fit ageing score project, a multidisciplinary approach to assess healthy ageing status.". Paper presented in EMBO Workshop "Systems biology: Linking chromatin and epigenetics to disease and development, 2023.
  11. Apolónio, Joana Dias; Fernandes, Mónica Teotónio; Pedro Castelo-Branco; Bragança, José. "CITED4 methylation status is a potential prognostic biomarker for glioma in elderly patients". Paper presented in International Conference Ageing Without Borders; December 6 and 7, 2022, Faro, Portugal., 2022.
  12. Apolónio, Joana Dias; Andrade, Raquel G. D.; Nádia Margarida Silva; Pedro Castelo-Branco; Ana Teresa Rajado; ALFA Score consortium. "ALFA Score - Algarve Fit Ageing Score Project, a multidisciplinary approach for ageing assessment". Paper presented in ABC Days, October 12 ¿ 14, 2022, Sagres, Portugal., 2022.
  13. Fernandes, Mónica T; Apolónio, Joana ; Pedro Castelo-Branco; Bragança, José. "CITED4 role in gliomas - revisiting previous studies and providing new clues". Paper presented in V Encontro Anual do Algarve Biomedical Center, 2022.
  14. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Paper presented in ABC-Days, 2022.
  15. Fernandes, Mónica T; Apolónio, Joana ; Pedro Castelo-Branco; Bragança, José. "CITED4 hypomethylation in the 3'UTR is associated with an adverse prognosis in glioblastoma.". Paper presented in 5th ASPIC International Congress, 2022.
  16. Apolonio, Joana Dias; Valadas, Gabriela; Dias, João Silva; Vânia Palma Roberto; Tabori, Uri; Pedro Castelo-Branco. "THOR: A DNA methylation-based marker for breast cancer". Paper presented in XVIII Senology Symposium (XVIII Jornadas de Senologia 2019). Portimão, Portugal, 2019.
  17. Jorge Pimenta; Apolónio, Joana ; Pedro Castelo-Branco; Pires V.M; Nolasco S. "Comportamento epigenético de genes do tipo priónico em células da granulosa de bovino.". Paper presented in XI Congreso Ibérico sobre Recursos Genéticos Animales. Murcia, Spain., 2018.
  18. Apolónio, Joana ; Pedro Castelo-Branco; Uri Tabori. "A DNA methylation-based marker for breast cancer management". Paper presented in Keystone Symposia Conference, Cancer Epigenetics: New Mechanisms, New Therapies. Breckenridge, Colorado, USA., 2018.
  19. Apolónio, Joana ; Bernardo Pereira de Almeida; Alexandra Binnie; Pedro Castelo-Branco. "Roadmap of DNA methylation in breast cancer identifies 15 novel potential biomarkers". Paper presented in 2nd CBMR/ProRegem Annual Meeting, Faro, Portugal., 2017.
  20. Vânia Palma Roberto; Apolónio, Joana ; Pedro Castelo-Branco. "Uncovering new epigenetic biomarkers in colorectal cancer.". Paper presented in 2nd CBMR/ProRegem Annual Meeting, Faro, Portugal., 2017.
  21. Conceição, Natércia; N Carrasco; Pedro Castelo-Branco; ML Cancela. "Molecular basis for the epigenetic regulation of MGP in cancer". Paper presented in 3th MEEting of MIM, 2017.
  22. Leão, Ricardo; Lee, Donghyun; Apolónio, Joana ; Figueiredo, Arnaldo; Pedro Castelo-Branco; Uri Tabori. "Integrated molecular signatures of TERT promoter deregulation predict disease progression in non-muscle invasive bladder cancer". Paper presented in Telomeres & Telomerase Meeting, Cold Spring Harbor, NY, USA., 2017.
  23. Apolónio, Joana ; Vânia Palma Roberto; Uri Tabori; Pedro Castelo-Branco. "Uncovering the potential of a DNA methylation-based biomarker for breast cancer.". Paper presented in Genetics and Genome Biology Annual Retreat. Sickkids Hospital, University of Toronto, Canada., 2017.
  24. Sara Ramalhete; Apolónio, Joana ; Pedro Castelo-Branco. "Dna Methylation patterns in oncogenes and tumor suppressors in breast cancer.". Paper presented in 1st CBMR/ProRegem Annual Meeting, Faro, Portugal., 2016.
  25. Apolónio, Joana ; Célia Domingos; Pedro Castelo-Branco. "Uncovering the potential of THOR as a biomarker for breast cancer". Paper presented in 2nd ASPIC International Congress, IPO, Porto, Portugal., 2016.
  26. Célia Domingos; Luís Relvas; Apolónio, Joana ; Pedro Castelo-Branco. "THOR methylation as a new tool for the clinical management of colorectal cancer". Paper presented in 2nd ASPIC International Congress, IPO, Porto, Portugal., 2016.
Journal article
  1. Nuno Marques; Apolónio, Joana ; Pedro Castelo-Branco. Corresponding author: Nuno Marques. "Impact of epigenetics on the development of transthyretin amyloid cardiomyopathy: A sistematic literature review.". Cardiology and Cardiovascular Medicine 10 1 (2026): 15-21.
    Published
  2. Marques, Nuno; Apolónio, Joana; Palmeirim, Isabel; Castelo Branco, Pedro; Azevedo, Olga. "Impact of Epigenetics on the Development of Transthyretin Amyloid Cardiomyopathy: A Systematic Literature Review". Cardiology and Cardiovascular Medicine 10 1 (2026): https://doi.org/10.26502/fccm.92920480.
    10.26502/fccm.92920480
  3. Francisco Cortez Nunes; Catarina Aguieiras; Mauro Calhindro; Ricardo Louro; Bruno Peixe; Patrícia Queirós; Pedro Castelo-Branco; Teresa Letra Mateus. "Molecular Detection of Multiple Antimicrobial Resistance Genes in <i>Helicobacter pylori</i>-Positive Gastric Samples from Patients Undergoing Upper Gastrointestinal Endoscopy with Gastric Biopsy in Algarve, Portugal". Antibiotics (2025): https://www.mdpi.com/2079-6382/14/8/780.
    10.3390/antibiotics14080780
  4. Francisco Cortez Nunes; Teresa Letra Mateus; Catarina Aguieiras; Ricardo Louro; Bruno Peixe; Mauro Calhindro; Patrícia Queirós; Pedro Castelo-Branco. "Prevalence and Diagnostic Comparison of Helicobacter pylori and Non-Helicobacter pylori Helicobacter Infections in Patients Undergoing Upper Gastrointestinal Endoscopy with Gastric Biopsy in Algarve, Portugal". Microorganisms (2025): https://doi.org/10.3390/microorganisms13071684.
    10.3390/microorganisms13071684
  5. António Paiva-Correia; Joana Apolónio; Alfons Nadal; José Ricardo Brandão; Nádia Silva; Bianca Machado; Ivan Archilla; Pedro Castelo-Branco; Henrik Hellquist. "Methylation Status of the Telomerase Reverse Transcriptase Promoter in Parotid Tumours and Adjacent Parotid Gland Tissue: A Pilot Study on the Implications for Recurrence and Development of Malignancy". Current Oncology (2025): https://doi.org/10.3390/curroncol32060312.
    10.3390/curroncol32060312
  6. Gui, C.; Wang, J.Z.; Patil, V.; Landry, A.P.; Singh, O.; Castelo-Branco, P.; Tabori, U.; et al. "Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study". Lancet Oncology 26 9 (2025): 1191-1203. https://www.scopus.com/inward/record.url?eid=2-s2.0-105014781696&partnerID=MN8TOARS.
    10.1016/S1470-2045(25)00267-0
  7. Paiva-Correia, A.; Hellquist, H.; Apolónio, J.; Castelo-Branco, P.. "Role of Ancillary Techniques in the Differential Diagnosis of Salivary Gland Carcinomas". APMIS 133 2 (2025): https://www.scopus.com/inward/record.url?eid=2-s2.0-85218142450&partnerID=MN8TOARS.
    10.1111/apm.70008
  8. Cunha, M.F.; Neves, J.C.; Roseira, J.; Pellino, G.; Castelo-branco, P.. "Green surgery: a systematic review of the environmental impact of laparotomy, laparoscopy, and robotics". Updates in Surgery 77 5 (2025): 1683-1692. https://www.scopus.com/inward/record.url?eid=2-s2.0-105005598678&partnerID=MN8TOARS.
    10.1007/s13304-025-02221-1
  9. Cardoso, C.; Pestana, D.; Gokuladhas, S.; Marreiros, A.D.; O'Sullivan, J.M.; Binnie, A.; Fernandes, M.T.; Castelo-Branco, P.. "Erratum: Identification of Novel DNA Methylation Prognostic Biomarkers for AML With Normal Cytogenetics". JCO Clinical Cancer Informatics 9 (2025): e2500012-e2500012. https://www.scopus.com/inward/record.url?eid=2-s2.0-85218917614&partnerID=MN8TOARS.
    10.1200/CCI-25-00012
  10. Cândida Cardoso; Daniel Pestana; Sreemol Gokuladhas; Ana D. Marreiros; Justin M. O'Sullivan; Alexandra Binnie; Mónica Teotónio Fernandes; Pedro Castelo-Branco. "Identification of Novel DNA Methylation Prognostic Biomarkers for AML With Normal Cytogenetics". JCO Clinical Cancer Informatics (2024): https://doi.org/10.1200/CCI.23.00265.
    10.1200/CCI.23.00265
  11. Santos, Daniela F.; Sónia Simão; Raquel P Andrade; Sofia Melo Calado; Gil Carraco; Joana Apolónio; Ana Teresa Rajado; et al. Corresponding author: Inês M Araújo. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters (2024): https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14995.
    Published
  12. Esteves, Filipa; Pedro Castelo-Branco; Apolónio, Joana. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research.". Stem Cell Research Vol 81 (2024):
    Published
  13. Esteves, F.; Brito, D.; Rajado, A.T.; Silva, N.; Apolónio, J.; Roberto, V.P.; Andrade, R.P.; et al. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research 81 (2024): https://www.scopus.com/inward/record.url?eid=2-s2.0-85206825471&partnerID=MN8TOARS.
    10.1016/j.scr.2024.103576
  14. Santos, D.F.; Simão, S.; Nóbrega, C.; Bragança, J.; Castelo-Branco, P.; Araújo, I.M.. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters 598 17 (2024): 2074-2091. https://www.scopus.com/inward/record.url?eid=2-s2.0-85200920413&partnerID=MN8TOARS.
    10.1002/1873-3468.14995
  15. D. V. C. Brito; F. Esteves; A. T. Rajado; N. Silva; ALFA Score Consortium; I. Araújo; J. Bragança; Pedro Castelo-Branco; C. Nóbrega. Corresponding author: C. Nóbrega. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging (2023):
    Open access • Published
  16. D. V. C. Brito; F. Esteves; A. T. Rajado; N. Silva; R. Andrade; J. Apolónio; S. Calado; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    10.1038/s41514-023-00120-6
  17. Filipa Esteves; David Brito; Ana Teresa Rajado; Nádia Silva; Joana Apolónio; Vânia Palma Roberto; Inês Araújo; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development (2023): https://doi.org/10.1016/j.mad.2023.111854.
    10.1016/j.mad.2023.111854
  18. Silva, Nádia; Vânia Palma Roberto; Pedro Castelo-Branco. Corresponding author: Pedro Castelo-Branco. "Measuring healthy ageing. Current and future tools". European Journal of Epidemiology (2023):
    Submitted
  19. Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David V.C.; ALFA Score Consortium; Binnie, Alexandra; Araújo, Inês Maria; et al. Corresponding author: Pedro Castelo-Branco. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging 15 8 (2023): 3191-3217.
    Published • 10.18632/aging.204668
  20. Silva, N.; Rajado, A.T.; Esteves, F.; Brito, D.; Apolónio, J.; Roberto, V.P.; Binnie, A.; et al. "Measuring healthy ageing: current and future tools". Biogerontology 24 6 (2023): 845-866. https://www.scopus.com/inward/record.url?eid=2-s2.0-85164771661&partnerID=MN8TOARS.
    10.1007/s10522-023-10041-2
  21. Apolónio, Joana Dias; Dias, João S.; Fernandes, Mónica Teotónio; Komosa, Martin; Lipman, Tatiana; Zhang, Cindy H.; Leão, Ricardo; et al. "THOR is a targetable epigenetic biomarker with clinical implications in breast cancer". Clinical Epigenetics 14 1 (2022): http://dx.doi.org/10.1186/s13148-022-01396-3.
    10.1186/s13148-022-01396-3
  22. Custodio, Luísa; Garcia-Caparros, Pedro; Pereira, Catarina Guerreiro; Castelo-Branco, Pedro. "Halophyte Plants as Potential Sources of Anticancer Agents: A Comprehensive Review". Pharmaceutics 14 11 (2022): 2406. http://dx.doi.org/10.3390/pharmaceutics14112406.
    10.3390/pharmaceutics14112406
  23. Alpoim-Moreira, Joana; Fernandes, Carina; Pimenta, Jorge; Bliebernicht, Miguel; Rebordão, Maria Rosa; Castelo-Branco, Pedro; Szóstek-Mioduchowska, Anna. "Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibrosis". Frontiers in Veterinary Science 9 (2022): http://dx.doi.org/10.3389/fvets.2022.970003.
  24. Joana Alpoim-Moreira; Carina Fernandes; Jorge Pimenta; Miguel Bliebernicht; Maria Rosa Rebordão; Pedro Castelo-Branco; Anna Szóstek-Mioduchowska; Dariusz J. Skarzynski; Graça Ferreira-Dias. "Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibrosis". Frontiers in Veterinary Science (2022): http://dx.doi.org/10.3389/fvets.2022.970003.
    10.3389/fvets.2022.970003
  25. Ana Rita Azevedo; Ana Sofia Pais; Teresa Almeida-Santos; Virgínia M. R. Pires; Pedro Pessa; Carla C. Marques; Sofia Nolasco; et al. "Medical Grade Honey as a Promising Treatment to Improve Ovarian Tissue Transplantation". Bioengineering (2022): http://dx.doi.org/10.3390/bioengineering9080357.
    10.3390/bioengineering9080357
  26. Pimenta, Jorge M.B.G.A.; Pires, Virgínia M.R.; Nolasco, Sofia; Castelo-Branco, Pedro; Marques, Carla C.; Apolónio, Joana; Azevedo, Rita; et al. "Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis". Biochemical and Biophysical Research Communications 598 (2022): 95-99. http://dx.doi.org/10.1016/j.bbrc.2022.02.012.
    10.1016/j.bbrc.2022.02.012
  27. Fonseca, André; Ramalhete, Sara Ventura; Mestre, André; Pires das Neves, Ricardo; Marreiros, Ana; Castelo-Branco, Pedro; Roberto, Vânia Palma. "Correction for: Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression". Aging 14 4 (2022): 2014-2015. http://dx.doi.org/10.18632/aging.203866.
    10.18632/aging.203866
  28. Ramon Andrade Bezerra De Mello; Rafael Voscaboinik; João Vittor Pires Luciano; Rafaela Vilela Cremonese; Giovanna Araujo Amaral; Pedro Castelo-Branco; Georgios Antoniou. "Immunotherapy in Patients with Advanced Non-Small Cell Lung Cancer Lacking Driver Mutations and Future Perspectives". Cancers (2021): https://doi.org/10.3390/cancers14010122.
    10.3390/cancers14010122
  29. Inês Faleiro; Vânia Palma Roberto; Secil Demirkol Canli; Nicolas A. Fraunhoffer; Juan Iovanna; Ali Osmay Gure; Wolfgang Link; Pedro Castelo-Branco. "DNA Methylation of PI3K/AKT Pathway-Related Genes Predicts Outcome in Patients with Pancreatic Cancer: A Comprehensive Bioinformatics-Based Study". Cancers (2021): https://doi.org/10.3390/cancers13246354.
    10.3390/cancers13246354
  30. Hélder Almeida-Lousada; André Mestre; Sara Ramalhete; Aryeh J. Price; Ramon Andrade de Mello; Ana D. Marreiros; Ricardo Pires das Neves; Pedro Castelo-Branco. "Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?". Current Oncology 28 6 (2021): 4874-4893. https://doi.org/10.3390/curroncol28060411.
    10.3390/curroncol28060411
  31. Lee, Donghyun D.; Komosa, Martin; Sudhaman, Sumedha; Leão, Ricardo; Zhang, Cindy H.; Apolonio, Joana D.; Hermanns, Thomas; et al. "Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer". Journal of Clinical Investigation 131 21 (2021): http://dx.doi.org/10.1172/jci146915.
    10.1172/jci146915
  32. Pedro Castelo-Branco. "Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression". Aging 13 18 (2021): 21991-22029. http://dx.doi.org/10.18632/aging.203556.
    10.18632/aging.203556
  33. Pedro Castelo-Branco. "Current and potential biomarkers in gastric cancer: a critical review of the literature". Future Oncology 17 25 (2021): 3383-3396. http://dx.doi.org/10.2217/fon-2021-0084.
    10.2217/fon-2021-0084
  34. Catarina Vizetto-Duarte; Pedro Castelo-Branco; Luísa Custódio. "Marine Natural Products as a Promising Source of Therapeutic Compounds to Target Cancer Stem Cells". Current Medicinal Chemistry 28 22 (2021): 4343-4355. https://doi.org/10.2174/0929867327666200320155053.
    10.2174/0929867327666200320155053
  35. Binnie, Alexandra; Fernandes, Emanuel; Almeida-Lousada, Helder; de Mello, Ramon Andrade; Castelo-Branco, Pedro. "CRISPR-based strategies in infectious disease diagnosis and therapy". Infection (2021): http://dx.doi.org/10.1007/s15010-020-01554-w.
    10.1007/s15010-020-01554-w
  36. De Mello, Ramon Andrade; Neves, Nathália Moisés; Amaral, Giovanna Araújo; Lippo, Estela Gudin; Castelo-Branco, Pedro; Pozza, Daniel Humberto; Tajima, Carla Chizuru; Antoniou, Georgios. "The Role of MET Inhibitor Therapies in the Treatment of Advanced Non-Small Cell Lung Cancer". Journal of Clinical Medicine 9 6 (2020): 1918. http://dx.doi.org/10.3390/jcm9061918.
    10.3390/jcm9061918
  37. Binnie, Alexandra; Tsang, Jennifer L. Y.; Hu, Pingzhao; Carrasqueiro, Gabriela; Castelo-Branco, Pedro; dos Santos, Claudia C.. "Epigenetics of Sepsis". Critical Care Medicine 48 5 (2020): 745-756. http://dx.doi.org/10.1097/ccm.0000000000004247.
    10.1097/ccm.0000000000004247
  38. De Mello, Ramon Andrade; Ayoub, Emili; Castelo-Branco, Pedro; De Almeida Zia, Victor Andre; Savio, Andre; Pozza, Daniel Humberto; Tadokoro, Hakaru; Teich, Nelson. "Comparative cost-effectiveness analysis of avelumab plus axitinib versus pembrolizumab plus axitinib, ipilimumab plus nivolumab, and sunitnib for advanced renal cell carcinoma in the U.K. Perspective.". Journal of Clinical Oncology 38 6_suppl (2020): 689-689. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.689.
    10.1200/jco.2020.38.6_suppl.689
  39. Binnie, Alexandra; Walsh, Christopher J.; Hu, Pingzhao; Dwivedi, Dhruva J.; Fox-Robichaud, Alison; Liaw, Patricia C.; Tsang, Jennifer L. Y.; et al. "Epigenetic Profiling in Severe Sepsis". Critical Care Medicine 48 2 (2020): 142-150. http://dx.doi.org/10.1097/ccm.0000000000004097.
    10.1097/ccm.0000000000004097
  40. Binnie, Alexandra; Tsang, Jennifer L. Y.; Hu, Pingzhao; Carrasqueiro, Gabriela; Castelo-Branco, Pedro; dos Santos, Claudia C.. "Epigenetics of Sepsis". Critical Care Medicine (2020): 1. http://dx.doi.org/10.1097/ccm.0000000000004247.
    10.1097/ccm.0000000000004247
  41. Pedro Castelo-Branco. "New target therapies in advanced non-small cell lung cancer: a review of the literature and future perspectives". Journal of Clinical Medicine (2020):
  42. Pedro Castelo-Branco. "A pilot study on DNA methylation profiles in critical Illness". Critical Care Medicine (2020):
  43. Pedro Castelo-Branco. "Comparative cost-effectiveness analysis of avelumab plus axitinib versus pembrolizumab plus axitinib, ipilimumab plus nivolumab, and sunitnib for advanced renal cell carcinoma in the UK perspective". Journal of Clinical Oncology 38 (2020): 689-689.
  44. de Mello, R.A.; Neves, N.M.; Tadokoro, H.; Amaral, G.A.; Castelo-Branco, P.; Zia, V.A.A.. "New target therapies in advanced non-small cell lung cancer: A review of the literature and future perspectives". Journal of Clinical Medicine 9 11 (2020): https://www.scopus.com/inward/record.url?eid=2-s2.0-85101592606&partnerID=MN8TOARS.
    10.3390/jcm9113543
  45. de Mello, R.A.; Zhu, J.-H.; Iavelberg, J.; Potim, A.H.; Simonetti, D.; Júnior, J.A.S.; Castelo-Branco, P.; et al. "Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: Is there a role in clinical practice?". Translational Lung Cancer Research 9 6 (2020): 2311-2314. https://www.scopus.com/inward/record.url?eid=2-s2.0-85100165611&partnerID=MN8TOARS.
    10.21037/tlcr-20-625
  46. Lee, Donghyun D.; Leão, Ricardo; Komosa, Martin; Gallo, Marco; Zhang, Cindy H.; Lipman, Tatiana; Remke, Marc; et al. "DNA hypermethylation within TERT promoter upregulates TERT expression in cancer". Journal of Clinical Investigation 129 1 (2019): 223-229. http://dx.doi.org/10.1172/jci121303.
    10.1172/jci121303
  47. De Mello, Ramon Andrade; Faleiro, Inês; Apolónio, Joana D; Tabori, Uri; Price, Aryeh J; Roberto, Vânia P; Castelo-Branco, Pedro. "Hot topics in epigenetic regulation of cancer self-renewal for pancreatic tumors: future trends". Future Oncology 15 7 (2019): 683-685. http://dx.doi.org/10.2217/fon-2018-0153.
    10.2217/fon-2018-0153
  48. Adashek, Jacob J; Aguiar, Pedro N; Castelo-Branco, Pedro; Lopes, Gilberto L; De Mello, Ramon Andrade. "PALOMA-3 clinical trial: is there a significant benefit in overall survival for breast cancer? Is it worth it?". (2019): http://hdl.handle.net/10400.1/12884.
    10.2217/fon-2019-0044
  49. Leão, Ricardo; Lee, Donghyun; Figueiredo, Arnaldo; Hermanns, Thomas; Wild, Peter; Komosa, Martin; Lau, Irene; et al. "Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer". (2019): http://hdl.handle.net/10400.1/12631.
    10.1002/ijc.31935
  50. Almeida, Bernardo; Apolónio, Joana; Binnie, Alexandra; Castelo-Branco, Pedro. "Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers". (2019): http://hdl.handle.net/10400.1/12432.
  51. da Cunha, Bianca Rodrigues; Domingos, Célia; Stefanini, Ana Carolina Buzzo; Henrique, Tiago; Polachini, Giovana Mussi; Castelo-Branco, Pedro; Tajara, Eloiza Helena. "Cellular interactions in the tumor microenvironment: the role of secretome". (2019): http://hdl.handle.net/10400.1/12812.
    10.7150/jca.21780
  52. da Cunha, Bianca Rodrigues; Domingos, Célia; Stefanini, Ana Carolina Buzzo; Henrique, Tiago; Polachini, Giovana Mussi; Castelo-Branco, Pedro; Tajara, Eloiza Helena. "Cellular Interactions in the Tumor Microenvironment: The Role of Secretome". Journal of Cancer 10 19 (2019): 4574-4587. http://dx.doi.org/10.7150/jca.21780.
    10.7150/jca.21780
  53. De Mello, Ramon Andrade; Aguiar, Pedro Nazareth; Tadokoro, Hakaru; Farias-Vieira, Tállita Meciany; Castelo-Branco, Pedro; de Lima Lopes, Gilberto; Pozza, Daniel Humberto. "MetaLanc9 as a novel biomarker for non-small cell lung cancer: promising treatments via a PGK1-activated AKT/mTOR pathway". Journal of Thoracic Disease 10 S16 (2018): S2076-S2078. http://dx.doi.org/10.21037/jtd.2018.04.122.
    10.21037/jtd.2018.04.122
  54. De Mello, Ramon Andrade; Castelo-Branco, Luis; Castelo-Branco, Pedro; Pozza, Daniel Humberto; Vermeulen, Louis; Palacio, Sofia; Salzberg, Matthew; Lockhart, A. Craig. "What Will We Expect From Novel Therapies to Esophageal and Gastric Malignancies?". American Society of Clinical Oncology Educational Book 38 (2018): 249-261. http://dx.doi.org/10.1200/edbk_198805.
    10.1200/edbk_198805
  55. Leão, Ricardo; van Agthoven, Ton; Fadaak, Kamel; Castelo-Branco, Pedro; Jewett, Michael; Sweet, Joan; E. Ahmad, Ardalan; et al. "MP37-08 SERUM MIRNA PREDICTS VIABLE DISEASE POST-CHEMOTHERAPY IN TESTICULAR NON-SEMINOMA GERM CELL TUMOR PATIENTS". Journal of Urology 199 4S (2018): http://dx.doi.org/10.1016/j.juro.2018.02.1214.
    10.1016/j.juro.2018.02.1214
  56. Gouvinhas, Cláudia; De Mello, Ramon Andrade; Oliveira, Daniela; Castro-Lopes, José Manuel; Castelo-Branco, Pedro; dos Santos, Ricardo Sales; Hespanhol, Venceslau; Pozza, Daniel Humberto. "Lung cancer: a brief review of epidemiology and screening". Future Oncology 14 6 (2018): 567-575. http://dx.doi.org/10.2217/fon-2017-0486.
    10.2217/fon-2017-0486
  57. Leão, Ricardo; Apolónio, Joana D.; Lee, Donghyun; Figueiredo, Arnaldo; Tabori, Uri; Castelo-Branco, Pedro. "Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer". (2018): http://hdl.handle.net/10400.1/10529.
    http://dx.doi.org/10.1186/s12929-018-0422-8
  58. De Mello, Ramon Andrade; Escriu, Carles; Castelo-Branco, Pedro; Cabral, Paloma Lucena; Mountzios, Giannis; Lopes, Gilberto de Lima; Madureira, Pedro. "Comparative outcome assessment of epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of advanced non-small-cell lung cancer: a network meta-analysis". Oncotarget 9 14 (2017): http://dx.doi.org/10.18632/oncotarget.23668.
    10.18632/oncotarget.23668
  59. Faleiro, Inês; Apolónio, Joana Dias; Price, Aryeh J; De Mello, Ramon Andrade; Roberto, Vânia Palma; Tabori, Uri; Castelo-Branco, Pedro. "The TERT hypermethylated oncologic region predicts recurrence and survival in pancreatic cancer". Future Oncology 13 23 (2017): 2045-2051. http://dx.doi.org/10.2217/fon-2017-0167.
    10.2217/fon-2017-0167
  60. Leão, Ricardo; Domingos, Célia; Figueiredo, Arnaldo; Hamilton, Robert; Tabori, Uri; Castelo-Branco, Pedro. "Cancer Stem Cells in Prostate Cancer: Implications for Targeted Therapy". Urologia Internationalis 99 2 (2017): 125-136. http://dx.doi.org/10.1159/000455160.
    10.1159/000455160
  61. Aguiar, Pedro N; Santoro, Ilka Lopes; Tadokoro, Hakaru; de Lima Lopes, Gilberto; Filardi, Bruno Andraus; Oliveira, Pedro; Castelo-Branco, Pedro; Mountzios, Giannis; de Mello, Ramon Andrade. "A pooled analysis of nivolumab for the treatment of advanced non-small-cell lung cancer and the role of PD-L1 as a predictive biomarker". Immunotherapy 8 9 (2016): 1011-1019. http://dx.doi.org/10.2217/imt-2016-0032.
    10.2217/imt-2016-0032
  62. Castelo-Branco, Pedro; Leão, Ricardo; Lipman, Tatiana; Campbell, Brittany; Lee, Donghyun; Price, Aryeh; Zhang, Cindy; et al. "A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: a retrospective cohort study". Oncotarget 7 36 (2016): http://dx.doi.org/10.18632/oncotarget.10639.
    10.18632/oncotarget.10639
  63. Aguiar, Pedro Nazareth; Muniz, Thiago Pimentel; Miranda, Raelson Rodrigues; Tadokoro, Hakaru; Forones, Nora Manoukian; Monteiro, Ines-de-Paula; Castelo-Branco, Pedro; Janjigian, Yelena Y; de Mello, Ramon Andrade. "Current advances in targeted therapies for metastatic gastric cancer: improving patient care". Future Oncology 12 6 (2016): 839-854. http://dx.doi.org/10.2217/fon.15.348.
    10.2217/fon.15.348
  64. Ernst, Aurélie; Jones, David T.W.; Maass, Kendra K.; Rode, Agata; Deeg, Katharina I.; Jebaraj, Billy Michael Chelliah; Korshunov, Andrey; et al. "Telomere dysfunction and chromothripsis". International Journal of Cancer 138 12 (2016): 2905-2914. http://dx.doi.org/10.1002/ijc.30033.
    10.1002/ijc.30033
  65. Castelo-Branco, Pedro; Leao, Ricardo; Lipman, Tatiana; Campbell, Brittany; Lee, Donghyun; Price, Aryeh; Zhang, Cindy; et al. "A cancer specific hypermethylation signature of the TERT promoter predicts biochemical relapse in prostate cancer: A retrospective cohort study". (2016): http://hdl.handle.net/10400.1/9293.
    10.18632/oncotarget.10639
  66. Faleiro, Inês; Leão, Ricardo; Binnie, Alexandra; Andrade de Mello, Ramon; Maia, Ana Teresa; Castelo-Branco, Pedro. "Epigenetic therapy in urologic cancers: an update on clinical trials". (2016): http://hdl.handle.net/10400.1/9150.
    10.18632/oncotarget.14226
  67. Aguiar, Pedro Nazareth Jr.; Muniz, Thiago Pimentel; Miranda, Raelson Rodrigues; Tadokoro, Hakaru; Forones, Nora Manoukian; Monteiro, Inês-de-Paula; Castelo-Branco, Pedro; Janjigian, Yelena Y.; Mello, Ramon Andrade de. "Current advances in targeted therapies for metastatic gastric cancer: improving patient care". (2016): http://hdl.handle.net/10400.1/9768.
    10.2217/fon.15.348
  68. Mistry, Matthew; Zhukova, Nataliya; Merico, Daniele; Rakopoulos, Patricia; Krishnatry, Rahul; Shago, Mary; Stavropoulos, James; et al. "BRAF Mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma". (2015): http://hdl.handle.net/10400.1/11546.
    10.1200/JCO.2014.58.3922
  69. Mangerel, Joshua; Price, Aryeh; Castelo-Branco, Pedro; Brzezinski, Jack; Buczkowicz, Pawel; Rakopoulos, Patricia; Merino, Diana; et al. "Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors". Acta Neuropathologica 128 6 (2014): 853-862. http://dx.doi.org/10.1007/s00401-014-1348-1.
    10.1007/s00401-014-1348-1
  70. Pedro Castelo-Branco. "Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells.". Acta Neuropathol. (2014):
  71. Taylor, M. D.; Mack, S.; Witt, H.; Dirks, P.; Pfister, S.; Korshunov, A.; Pedro Castelo-Branco. "EPIGENOME ALTERATIONS DEFINE LETHAL CIMP POSITIVE EPENDYMOMAS OF INFANCY". Nature (2014): http://10.1038/nature13108.
    10.1093/neuonc/nou206.58
  72. Pedro Castelo-Branco. "Comprehensive genomic analysis of diffuse intrinsic pontine gliomas unravels three molecular subgroups and a novel cancer driver.". Nature Genetics, (2014):
    10.1038/ng.2936.
  73. Zhukova, Nataliya; Ramaswamy, Vijay; Remke, Marc; Martin, Dianna C.; Castelo-Branco, Pedro; Zhang, Cindy H.; Fraser, Michael; et al. "WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma". (2014): http://hdl.handle.net/10400.1/12046.
    10.1186/s40478-014-0174-y
  74. Barszczyk, Mark; Buczkowicz, Pawel; Castelo-Branco, Pedro; Mack, Stephen C.; Ramaswamy, Vijay; Mangerel, Joshua; Agnihotri, Sameer; et al. "Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells". (2014): http://hdl.handle.net/10400.1/11219.
    10.1007/s00401-014-1327-6
  75. Pedro Castelo-Branco. "Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.". Nature (2014):
  76. Pedro Castelo-Branco. "Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.". Journal of Clinical Oncology. (2013): http://europepmc.org/abstract/med/23835706.
    10.1200/JCO.2012.48.5052
  77. Castelo-Branco, Pedro; Choufani, Sanaa; Mack, Stephen; Gallagher, Denis; Zhang, Cindy; Lipman, Tatiana; Zhukova, Nataliya; et al. "Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study". The Lancet Oncology 14 6 (2013): 534-542. http://dx.doi.org/10.1016/s1470-2045(13)70110-4.
    10.1016/s1470-2045(13)70110-4
  78. Pedro Castelo-Branco. "Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.". The Lancet Oncology (2013): http://europepmc.org/abstract/med/23598174.
    10.1016/S1470-2045(13)70110-4
  79. Castelo-Branco, Pedro; Tabori, Uri. "Promises and challenges of exhausting pediatric neural cancer stem cells". Pediatric Research 71 2-4 (2012): 523-528. http://dx.doi.org/10.1038/pr.2011.63.
    10.1038/pr.2011.63
  80. Pedro Castelo-Branco. "Monoallelic Expression Determines Oncogenic Progression and Outcome in Benign and Malignant Brain Tumors". Journal of Cancer Research and Oncobiology (2012):
  81. Pedro Castelo-Branco. "Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumors.". Cancer Research (2012): http://europepmc.org/abstract/med/22144470.
    10.1158/0008-5472.CAN-11-2266
  82. Pedro Castelo-Branco. "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.". Nature (2012): http://europepmc.org/abstract/med/22286061.
    10.1038/nature10833
  83. Castelo-Branco, P.; Zhang, C.; Lipman, T.; Fujitani, M.; Hansford, L.; Clarke, I.; Harley, C. B.; et al. "Neural Tumor-Initiating Cells Have Distinct Telomere Maintenance and Can be Safely Targeted for Telomerase Inhibition". Clinical Cancer Research 17 1 (2011): 111-121. http://dx.doi.org/10.1158/1078-0432.ccr-10-2075.
    10.1158/1078-0432.ccr-10-2075
  84. Pedro Castelo-Branco. "Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition.". Clinical Cancer Research (2011): http://europepmc.org/abstract/med/21208905.
    10.1158/1078-0432.CCR-10-2075
  85. Pedro Castelo-Branco. "Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer.". Gene Therapy (2010): http://www.ncbi.nlm.nih.gov/pubmed/20220784.
  86. Castelo-Branco, P; Passer, B J; Buhrman, J S; Antoszczyk, S; Marinelli, M; Zaupa, C; Rabkin, S D; Martuza, R L. "Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer". Gene Therapy 17 6 (2010): 805-810. http://dx.doi.org/10.1038/gt.2010.20.
    10.1038/gt.2010.20
  87. Pedro Castelo-Branco. "Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells.". Cancer Gene Therapy (2009):
  88. Passer, B J; Castelo-Branco, P; Buhrman, J S; Varghese, S; Rabkin, S D; Martuza, R L. "Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells". Cancer Gene Therapy 16 7 (2009): 551-560. http://dx.doi.org/10.1038/cgt.2009.10.
    10.1038/cgt.2009.10
  89. Liu, Ta-Chiang; Castelo-Branco, Pedro; Rabkin, Samuel D; Martuza, Robert L. "Trichostatin A and Oncolytic HSV Combination Therapy Shows Enhanced Antitumoral and Antiangiogenic Effects". Molecular Therapy 16 6 (2008): 1041-1047. http://dx.doi.org/10.1038/mt.2008.58.
    10.1038/mt.2008.58
  90. Binnie, A.. "Homologous gene sequences mediate transcription-domain formation". Journal of Cell Science 119 18 (2006): 3876-3887. http://dx.doi.org/10.1242/jcs.03050.
    10.1242/jcs.03050
  91. Castelo-Branco, P.; Furger, A.; Wollerton, M.; Smith, C.; Moreira, A.; Proudfoot, N.. "Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation". Molecular and Cellular Biology 24 10 (2004): 4174-4183. http://dx.doi.org/10.1128/mcb.24.10.4174-4183.2004.
    10.1128/mcb.24.10.4174-4183.2004
  92. Pedro Castelo-Branco. "Polypyrimidine tract binding protein modulates efficiency of polyadenylation". Mol. Cell. Biol. (2004):
    10.1128/MCB.24.10.4174-4183.2004
Preprint
  1. Miguel Fernandes Cunha; Beatriz Mendes; Pedro Mendanha; Ines Miguel; Juan Rachadell; Edgar Amorim; Pedro Castelo-Branco. "Albumin and CRP, Which is the Best Biomarker for Postoperative Complications on Colorectal Surgery? Prospective Cohort Study". 2021. http://dx.doi.org/10.21203/rs.3.rs-1037006/v1.
    10.21203/rs.3.rs-1037006/v1
Thesis / Dissertation
  1. Ramalhete, Sara Maria Ventura. "Epigenetic biomarkers as predictors of clinical outcomes in colorectal cancer". Master, 2019. http://hdl.handle.net/10400.1/13422.
  2. Fonseca, André Filipe Afonso de Sousa. "Epigenetic of colorectal cancer: a focus on microRNAs". Master, 2018. http://hdl.handle.net/10400.1/12546.
  3. Pagliaro, Sarah Beatriz de Oliveira. "Cancro da próstata : efeitos da quimioterapia in vitro em células estaminais cancerígenas". Master, 2013. http://hdl.handle.net/10316/35775.

Artistic / Performance

Visual artwork
  1. Santos, Tiago; Branco, Pedro; Rebelo, Sérgio M.. Esperança, Short movie (art direction, montage, and graphic design). 2013..

Intellectual property

Patent
  1. Pedro Castelo-Branco. 2018. "Method of diagnosing cancer comprising detection of the methylation signature in the hTERT promoter.". United States.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/12 Marcadores epigenéticos: A nova era da genética molecular. Jornadas ALTBiotech
Instituto Nacional de Investigação em Agronomia e Veterinária (Santarém, Portugal)
2019/02 TERT regulation in cancer: a potential therapeutic target. Epigenetic Chemical Biology COST CM1406 Scientific Workshop
Universidade do Algarve (Faro)
2019/01 Epigenética no cancro colorectal. I Jornadas de cirurgia colorrectal do Algarve
(Portimão)
2018/12 Tumor Heterogeneity – what do we need to be aware of …1st Portuguese Symposium on Research and Innovation in Urology
CUF Hospitals (Lisboa)
2018 Clinical applications of epigenetic biomarkers in cancer diagnosis and prognosis MEDLAB Europe, 18 Conferences
(Barcelona)
2016/11 Epigenetics in cancer: From Bench to Clinic V Simpósio Ciências Biomédicas
(Faro)
2016/06 TERT: factor de prognóstico nos tumores cerebrais pediátricos 2nd MEEting do MIM
Universidade do Algarve (Faro)
2015/06 TERT Hypermethylated Oncologic Region - THOR: a new epigenetic cancer biomarker.
IPATIMUP (Porto)
2015/03 TERT Hypermethylated Oncologic Region - THOR: a new epigenetic cancer biomarker. VI Jornadas de Ciencias Biomédicas
2014/11 TERT Hypermethylated Oncological Region - THOR predicts biochemical relapse amongst prostate cancer patients 1st ASPIC International meeting
2013/06 THOR methylation provides insight into the telomere maintenance landscape of malignant gliomas
(Quebec City, Canada)
2013/05 Methylation of a specific region in the hTERT promoter is a cancer signature which correlates with tumor grade and patient survival.
(Florida)
2013/04 hTERT promoter methylation: a DNA based epigenetic cancer biomarker Global Biomarker Conference
(Toronto, Canada)
2012/10 hTERT promoter methylation: An epigenetic cancer biomarker. CNC
Universidade de Coimbra
2012/10 hTERT promoter methylation: A DNA-based cancer biomarker Cancer Research Center
2012/10 From cancer stem cell therapies to the development of a brain tumor biomarker PhD program
Faculdade de Medicina de Coimbra
2012/06 A specific region in the hTERT promoter can predict malignancy and survival in patients with childhood brain tumors. . 15th International Symposium on Pediatric Neuro-Oncology
ISPNO (Toronto)
2011/04 Neural tumor initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
2010/06 Selective targeting of neural tumor initiating cells by telomerase inhibition 14th International Symposium on Pediatric Neuro-Oncology
(Vienna)
2010/05 Selective targeting of neural tumor initiating cells by telomerase inhibition 7th Canadian Telomeres and Telomerase Symposium
2010/04 Selective Targeting of Pediatric Neural Stem Cells by Telomerase Inhibition CNC
Universidade de Coimbra
2010/04 Telomeres and Telomerase in Aging and Cancer.
Universidade de Aveiro
2009/01 Fighting Tumors with virus and telomerase inhibitors
Universidade do Algarve
2003/08 Polypyrimidine Tract Binding Protein modulates efficiency of polyadenylation Eukaryotic mRNA processing meeting
(Cold Spring Harbor)
2000/09 PTB, a multifunctional protein, is a component of the C2 mRNA 3´end formation machinery. XII Congresso de Bioquímica

Supervision

Thesis Title
Role		 Degree Subject (Type)
Institution / Organization
2023 - Current Ageing Well in Algarve: A Clinical, Molecular and Geospatial integrative analysis into Elderly Health and Fitness
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2022 - Current Intestinal microbiome of aging in the South of Portugal
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2021 - Current Epigenetic profile of epithelial tumors of the parotid gland: influence on their differentiation, progression, prognosis and treatment
Supervisor
 Investigação Clínica e Medicina Translacional (PhD)
Universidade do Algarve, Portugal
2020 - Current Endothelium non-codificant transcriptome in Neurofibromatosis type 1: instructing cancer".
Co-supervisor
 Investigação Clínica e Medicina Translacional (PhD)
Universidade do Algarve, Portugal
2020 - Current Environmental Sustainability in Surgery
Supervisor
 Investigação Clínica e Medicina Translacional (associação) (PhD)
Universidade do Algarve, Portugal
2019 - Current Epidemiologia molecular de biomarcadores de cancro esófago-gástrico
Co-supervisor
Universidade Federal de São Paulo Departamento de Medicina, Brazil
2017 - Current Epigenetic biomarker development and big data analysis in Colorectal Cancer
Supervisor
 Investigação Clínica e Medicina Translacional (PhD)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2019 - 2023 Modulating Receptor Activation, Migration and Epigenetics of Cancer Cells using UV light
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2018 - 2020 Epigenetic Hotspots in cancer
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2018 - 2020 Uncovering differential DNA methylation alterations in subtypes of Acute Myeloid Leukemia
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2019 - 2019 Epigenetic biomarkers as predictors of clinical outcomes in colorectal cancer
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2015 - 2019 The diagnostic, prognostic and therapeutic role of THOR in breast cancer.
Supervisor
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2015 - 2019 The role of telomere maintenance in urologic maligancies.
Supervisor
2015 - 2019 TERT HYPERMETHYLATED ONCOLOGIC REGION (THOR) AS A BIOMARKER FOR BREAST CANCER
Supervisor
 Mecanismos de Doença e Medicina Regenerativa (associação) (PhD)
Universidade do Algarve, Portugal
2018 - 2018 Epigenetic of colorectal cancer: a focus on microRNAs
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2017 - 2017 Epigenetic Regulation of Signalling Pathways in Pancreatic Cancer
Supervisor
 Ciências Biofarmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Epigenetic alterations in sepsis
Supervisor
 Oncobiologia - Mecanismos Moleculares do Cancro (Master)
Universidade do Algarve, Portugal
2013 - 2017 Proliferación cellular y regulacíon de Telomerasa en el cáncer de mama.
Co-supervisor

Jury of academic degree

Topic
Role		 Candidate name (Type of degree)
Institution / Organization
2020 Melanoma in zebrafish disregards telomere maintenance mechanisms.
(Thesis) Main arguer
 Joana Nabais (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/06 Thymic stromal factors promoting T-cell leukemia Marinella Nobre Ghezzo (PhD)
2017/06 MicroRNA Deregulation in Prostate Cancer
(Thesis) Main arguer
 João António Ramalho Carvalho (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/06 Biophysical modulation of cell fate through chromatin remodeling.
(Thesis) Main arguer
 Ana Francisca Silva de Lima (PhD)
Universidade Nova de Lisboa, Portugal
2017/06 The impact f non-coding alterations in glioma: hints from HOTAIR and the TERT promoter
(Thesis) Main arguer
 Ana Xavier Silva Magalhães (PhD)
Universidade do Minho Escola de Medicina, Portugal
2016 Unravelling the genetics of neuroendocrine tumors
(Thesis) Main arguer
 João Pedro Rico de Oliveira Vinagre (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 HOXA9 as a key regulator in glioma initiation, aggressiveness and response to therapy.
(Thesis) Main arguer
 Marta Sofia Pojo Sousa (PhD)

Association member

Society Organization name Role
2016 - Current Algarve Biomedical Center Member of the Executive Committee

Committee member

Activity description
Role		 Institution / Organization
2020 - Current National Clinical Academic Centres Council
Member
2020 - Current Doctoral Program in Clinical Research
Member
 Universidade do Algarve, Portugal
2020 - Current Advisory Committee SciELO
Member
2018 - Current Doctoral Program in Mechanisms of Disease and Regenerative Medicine, University of Algarve/Nova Lisbon University - Board member
Member
2016 - Current Algarve Biomedical Center Member of the Executive Committee
President / Vice-president
 Algarve Biomedical Center, Portugal
2015 - Current Department of Biomedical Sciences and Medicine Scientific Council
Member
2014 - Current Genetic Toxicology – Master´s Degree in Oncobiology.
Coordinator
 Universidade do Algarve, Portugal
2014 - Current Elective – Medical Degree.
Coordinator
 Universidade do Algarve, Portugal
2014 - Current Epigenetics – Biomedical Sciences Degree.
Coordinator
 Universidade do Algarve, Portugal
2019 - 2021 Integrated Masters in Medicine Appeal Committee
President / Vice-president
 Universidade do Algarve, Portugal
2019 - 2020 Coordinating Section of the Academic Senate
Member
 Universidade do Algarve, Portugal
2018 - 2019 Integrated Masters in Medicine Appeal Committee
Member
 Universidade do Algarve, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014 - Current Tumor Progression (Master's Degree) Universidade do Algarve, Portugal
2014 - Current Eukaryotic Molecular Genetics - Master´s Degree in Microbial and Molecular Biology (Master's Degree) Universidade do Algarve, Portugal
2014 - Current Oncolabs I – Master´s Degree in Oncobiology (Master's Degree) Universidade do Algarve, Portugal
2014 - Current Problem Based Learning – Medical Degree. (Integrated Master's Degree)
2014 - Current Human Genetics – Biomedical Sciences Degree (Licenciate Degree) Universidade do Algarve, Portugal
2014 - Current Congenital Diseases – Biomedical Sciences Degree (Licenciate Degree) Universidade do Algarve, Portugal
2019/06 - 2019/06 How to communicate ideas, projects and results.
2019/06 - 2019/06 Epigenetic TERT regulation in cancer: from bench to bedside
2018/05 - 2018/05 Epigenetic TERT regulation in cancer: from bench to bedside University of New South Wales, Australia
2016/11 - 2016/11 TERT Hypermethylated Oncologic Region - THOR: a new epigenetic cancer biomarker Oxford Brookes University, United Kingdom
2016/10 - 2016/10 Epigenetics in cancer: From Bench to Clinic. Epigenética Aplicada ao Diagnóstico Laboratorial Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2015/12 - 2015/12 A metilação do promotor TERT como factor de prognóstico nos tumores cerebrais pediátricos
2015/12 - 2015/12 TERT Hypermethylated Oncologic Region - THOR: a new epigenetic cancer biomarker
2006 - 2007 Teaching fellow in Biological Sciences Molecular Biology Harvard University Department of Molecular and Cellular Biology, United States
2002 - 2003 Molecular biology laboratory techniques University of Oxford Medical Sciences Division, United Kingdom

Mentoring / Tutoring

Topic Student name
2006 - 2008 Biological Sciences .
Distinctions

Award

2013 First Prize, Genetics & Genome Biology and Molecular Medicine Program Meeting, oral competition
University of Toronto Faculty of Medicine, Canada
2010 The Hospital for Sick Children Genetics and Genome Biology Meeting poster competition
Hospital for Sick Children SickKids Learning Institute, Canada
1999 Scientific Investigator’s Award
Governo da República Portuguesa, Portugal

Other distinction

2018 Tech2Marquet Honourable Mention
Universidade do Algarve, Portugal
2003 Gustav Born Scholarship in Biomedical Sciences
2000 Praxis XXI Pre-Doctoral Scholarship
Governo da República Portuguesa, Portugal
1997 Erasmus Scholarship