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Tânia Lourenço is a PhD student at University of Coimbra. Her PhD project was awarded with a FCT scholarship (SFRH/BD/114731/2016) and has been developed at Mário Grãos’s lab at Center for Neuroscience and Cell Biology in collaboration with Gonçalo Castelo-Branco’s lab at Karolinska institute. She obtained her Bachelor and Master’s degree at University of Coimbra. Her main research field is Cell Mechanobiology with particularly interest on how brain mechanical properties change in neurodegenerative diseases and its influence oligodendrocyte biology. Publications include Nature Communications and Frontiers in Cellular Neuroscience. Was involved in several outreach and educational activities for science dissemination to the community, including talks for high school students, teachers, elderly and population in general, including activities & courses promoted by IEC and Brain Awareness Week.
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Identification

Personal identification

Full name
Tânia Milene Pires Lourenço

Citation names

  • Lourenço, Tânia

Author identifiers

Ciência ID
DF10-6CAF-19E7
ORCID iD
0000-0003-1198-8117

Telephones

Telephone
  • 231419040 (Professional)

Addresses

  • Center for Neuroscience and Cell Biology - UC Biotech. Parque Tecnológico de Cantanhede, Núcleo 04, Lote 8, 3060 - 197, Cantanhede, Cantanhede, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2021/01 - 2023/01
Ongoing
 MBA para Executivos (Especialização pós-licenciatura)
Universidade de Coimbra Faculdade de Economia, Portugal
2017/09 - 2022/08/31
Ongoing
 Biologia Experimental e Biomedicina (Doutoramento)
Major in Biotecnologia e Saúde
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
"Role of SP1 and Padi2 on oligodendrocyte differentiation enhanced by mechanotransduction" (THESIS/DISSERTATION)
2012
Concluded
 Biologia Celular e Molecular (Mestrado integrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Regulation of ECM mimetics during oligodendrocyte differentiation in vitro" (THESIS/DISSERTATION)
 17 values 0-20
2007/09/20 - 2010/07/20
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"N/A" (THESIS/DISSERTATION)
 14 Values (0-20)
Affiliation

Science

Category
Host institution 		Employer
2015/10/01 - 2017/05/01 Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015 - 2015 Research Assistant (Research) CNC.IBILI, Portugal

Others

Category
Host institution 		Employer
2017/05/01 - Current FCT PhD scholarship reference SFRH/BD/114731/2016 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/10/01 - 2015/09/30 Research fellow - Project: Differentiation of mesenchymal stem cells to oligodendroglial lineage: complementary roles of soluble factors, extracellular matrix and mechanotransduction Biocant Associação de Transferência de Tecnologia, Portugal
Biocant Associação de Transferência de Tecnologia, Portugal
2015/05/11 - 2015/05/13 mRNA reprogramming training course by Stemgent at University of Sheffield Blackwell's University of Sheffield, United Kingdom
2015/03/14 - 2015/03/15 Participation in science communication activities organized by the science communication group of CNC during Brain's international week. The activities consisted on the demonstration of techniques use Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/03/12 - 2014/03/14 Hands on course on microscopy imaging analysis. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/09/01 - 2012/09/10 Master student in Molecular and Cell Biology Biocant Associação de Transferência de Tecnologia, Portugal
2009/11/01 - 2010/08/01 Laboratory trainee in Genetics laboratory Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2017/05 - Current Role of SP1 and PADI2 during oligodendrocyte differentiation enhanced by mechanotransduction
SFRH/BD/114731/2016
 Universidade de Coimbra
2018/07/26 - 2021/07/25 Brain Elasticity in Multiple Sclerosis and implications in mechanomodulation of oligodendrocytes: a cellular and clinical approach
PTDC/MED-NEU/29516/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2012/10 - 2015/08 Differentiation of mesenchymal stem cells to oligodendroglial lineage: complementary roles of soluble factors, extracellular matrix and mechanotransduction
Provided by PTCRIS: 119292
119292
 Fundação para a Ciência e a Tecnologia, I.P.

Contract

Designation Funders
2017/05 - Current Role of SP1 and PADI2 during oligodendrocyte differentiation enhanced by mechanotransduction
POCI-01-0145-FEDER-029516
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Ongoing
Outputs

Publications

Conference poster
  1. Lourenço, Tânia; Gerardo, Heloísa; Ana Mendanha Falcão; Castelo-Branco, Gonçalo; Grãos, Mário. "The role of PADI2 on oligodendrocyte differentiation enhanced by mechanotransduction". Paper presented in VI Nanoengineering for Mechanobiology, 2022.
  2. Lourenço, Tânia; Gisela Filipa Assunção Santos; Ana Mendanha Falcão; Castelo-Branco, Gonçalo; Grãos, Mário. "Matrix stiffness contributes to efficient oligodendrocyte differentiation altering chromatin accessibility". Paper presented in VI Nanoengineering for Mechanobiology, 2022.
  3. Lourenço, Tânia; Gerardo, Heloísa; Ana Mendanha Falcão; Gonçalo Castelo-Branco; Grãos, Mário. "The role of PADI2 on oligodendrocyte differentiation enhanced by mechanotransduction". Paper presented in XVI — BEB day — Overview effect, 2022.
  4. Lourenço, Tânia; Gisela Filipa Assunção Santos; Ana Mendanha Falcão; Castelo-Branco, Gonçalo; Grãos, Mário. "Matrix stiffness contributes to efficient oligodendrocyte differentiation altering chromatin accessibility". Paper presented in XVI — BEB day — Overview effect, 2022.
  5. Lourenço, Tânia; Gisela Filipa Assunção Santos; Ana Mendanha Falcão; Castelo-Branco, Gonçalo; Grãos, Mário. "Matrix stiffness contributes to efficient oligodendrocyte differentiation altering chromatin accessibility". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  6. Lourenço, Tânia; Gerardo, Heloísa; Ana Mendanha Falcão; Castelo-Branco, Gonçalo; Grãos, Mário. "The role of PADI2 on oligodendrocyte differentiation enhanced by mechanotransduction". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  7. Lourenço, Tânia; Falcão, Mendanha Ana; Castelo-Branco, Gonçalo; Grãos, Mário. "Epigenetic changes in oligodendrocyte enhanced by mechanotransduction". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  8. Lourenço, Tânia; Falcão, Mendanha Ana; Castelo-Branco, Gonça; Grãos, Mário. "Epigenetic changes in oligodendrocyte enhanced by mechanotransduction". Paper presented in Epigenetics in nervous system, 2018.
  9. Lourenço, Tânia; Faria, Joana Paes de; Maia, João; Silva, José Lopes da; Grãos, Mário. "Enhancement of the differentiation and maturation of oligodendrocyte progenitors cells by mechanical cues". 2014.
  10. Lourenço, Tânia; Maia, João; Silva, José Lopes da; Grãos, Mário. "Hydrogel-based platforms for oligodendrocyte progenitors maintenance and differentiation". Paper presented in 1st Research Coimbra, 2013.
  11. Grãos, Mário; Lourenço, Tânia; Maia, João; Silva, José Lopes da. "Hydrogel-based platforms for oligodendrocyte progenitors maintenance and differentiation". Paper presented in Exciting Biologies: Forces in Biology, 2012.
  12. Lourenço, Tânia; Valentim, Ana; Luís, Daniela; Eufrásio, Ana; Oliveira, R. Catarina; Grazina, Manuela. "Pharmacogenomics of opioid pain treatment in postcesarean analgesia: contribution of 5HTR2A 102C>T polymorphism". Paper presented in 14th Annual meeting of the Portuguese Society of Human Genetics, 2010.
Journal article
  1. Floriddia, Elisa M.; Lourenço, Tânia; Zhang, Shupei; van Bruggen, David; Hilscher, Markus M.; Kukanja, Petra; Gonçalves dos Santos, João P.; et al. "Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19453-x.
    10.1038/s41467-020-19453-x
  2. Lourenço, T.; Paes De Faria, J.; Bippes, C.A.; Maia, J.; Lopes-Da-Silva, J.A.; Relvas, J.B.; Graõs, M.. "Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958568082&partnerID=MN8TOARS.
    10.1038/srep21563
  3. Lourenço, T.; Grãos, M.. "Modulation of oligodendrocyte differentiation by mechanotransduction". Frontiers in Cellular Neuroscience 10 NOV2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85007417961&partnerID=MN8TOARS.
    10.3389/fncel.2016.00277
  4. Leite, C.; Silva, N.T.; Mendes, S.; Ribeiro, A.; De Faria, J.P.; Lourenço, T.; Santos, F.D.; et al. "Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage". PLoS ONE 9 10 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84910047126&partnerID=MN8TOARS.
    10.1371/journal.pone.0111059
Thesis / Dissertation
  1. Lourenço, Tânia Milene Pires. "Regulation of ECM mimetics during oligodedrocytes differentiation in vitro". Master, 2012. http://hdl.handle.net/10316/25149.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/04/26 Extracellular stiffness contributes to efficient oligodendrocyte differentiation Master in Molecular and Translational Neurosciences 2021/2022 "Movement and Demyelinating Disorders"
Sónia Batista (Coimbra, Portugal)
2013/12 Hydrogel-based platforms for oligodendrocyte progenitors maintenance and differentiation BSRT PhD symposium
BSRT PhD students (Berlin, Germany)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/09 - 2018/09 Explain my research project to general public.
Other
 European Researchers' night 2018
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2018 Participation in a project entitled "sub-30 selection" organized by Ciência Viva centre (Coimbra). In this project I gave some talks for high school students in different high schools.
Other
 Sub-30 selection
Ciência Viva, Portugal
2015/06 - 2015/06 Lecture about cell culture techniques to Biotechnology Bachelor students
Seminar
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2015/03/14 - 2015/03/15 Participation in the Science communication activities during “International week of the brain”
Other
 International week of the brain
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/06 - 2014/06 Lecture to Biotechnology Bachelor's Students entitled "Influence of extracellular matrix on oligodendrocyte progenitor cells differentiation"
Seminar
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
Distinctions

Award

2021 PhD scholarship
Fundação para a Ciência e a Tecnologia, I.P. , Portugal

Other distinction

2017 PhD sholarship
Fundação para a Ciência e a Tecnologia, Portugal