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Graduation in Physics Engineering by the University of Coimbra, Portugal. PhD in Physics by the Darmstadt University of Technology, Germany. Worked at the German heavy ion tumor therapy project for 7.5 years as PhD candidate and as postdoc researcher. Work involved physical and technological developments, and participation in the treatment of more than 200 cancer patients with carbon ion radiotherapy at GSI in Darmstadt. Co-invented 2 patents granted to his former laboratory HZDR in Dresden, Germany. Works since 2007 in Portugal at LIP Coimbra, as principal investigator since 2009. Lectured for 3 years at the Polytechnic Institute of Coimbra and was assistant professor at the Physics Department of the University of Coimbra between 2013 and 2025. Coauthored 54 publications in international, peer-reviewed journals. IoP (Institute of Physics) awarded to one of his first-author publication in Physics in Medicine and Biology the highlight of 2006, an yearly distinction to the top 10 scientific articles of largest impact within the journal. Coauthored 4 chapters in 2 books in nuclear medicine, is a reviewer of 10 different journals and has refereed, by invitation, international funding projects amounting to above 1 million Euro. Coauthor of the proposal of the project Rad4Life, which was financed with 1.2 million Euro between July 2013 and September 2015. Has supervised 20 master theses and 4 doctoral works at the University of Coimbra. Presently working on (1) R&D of imaging devices for assisting and potentially improving the effectiveness of external X-ray and proton beam radiotherapy (orthogonal X-rays, prompt gamma imaging, and in-beam time-of-flight positron emission tomography-PET), (2) PET with resistive plate chambers, and (3) new device for deep- and whole-brain transcranial magnetic stimulation. As principal investigator, attracted more than 400 thousand Euro, managed by LIP Coimbra between 2020 and 2024, distributed over several of the aforementioned lines of research.
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Identification

Personal identification

Full name
Paulo Alexandre Vieira Crespo

Citation names

  • Crespo, Paulo
  • Crespo, P

Author identifiers

Ciência ID
DE18-4FCE-42DB
ORCID iD
0000-0002-0891-032X

Email addresses

  • crespo@lip.pt (Professional)

Telephones

Mobile phone
  • 926131578 (Personal)
Telephone
  • 239410664 (Professional)

Addresses

  • LIP - Laboratório de Instrumentação e Física Experimenal de Partículas. Departamento de Física da Universidade de Coimbra, 3004-516, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging
  • Exact Sciences - Physical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2005/12/21
Concluded
 Physik (Doutoramento)
Technische Universität Darmstadt Fachbereich Physik, Germany
"Optimization of In- Beam Positron Emission Tomography for Monitoring Heavy Ion Tumor Therapy" (THESIS/DISSERTATION)
1997/07/30
Concluded
 Engenharia Física (Licenciatura)
Major in Instrumentation
Universidade de Coimbra Departamento de Física, Portugal
"Estudo do sinal de carga numa câmara com xénon líquido para tomografia por emissão de positrões" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2007/06/01 - Current Principal Investigator (Research) Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal
2006/01/01 - 2007/04/30 Auxiliary Researcher (Research) Helmholz-Zentrum Dresden-Rossendorf, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2013/11/15 - 2025/09/28 Assistant Professor (University Teacher) Universidade de Coimbra, Portugal
2008/09/01 - 2011/07/31 Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Coimbra, Portugal
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
Projects

Contract

Designation Funders
2021/01/01 - 2025/04/30 Laboratório de Instrumentação e Física Experimental de Partículas
LA/P/0016/2020
10.54499/LA/P/0016/2020
Researcher
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2022/01/01 - 2024/08/31 Optimization, construction and first in-beam tests of range monitoring and quality assurance systems for the improvement of proton therapy
CERN/FIS-TEC /0017/2021
Principal investigator
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/06/30 TPPT - In-beam time-of-flight positron emission tomography for proton radiation therapy
CENTRO-01-0247-FEDER-045904
Principal investigator
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Agência Nacional de Inovação SA
Concluded
2020/01/01 - 2021/12/31 Proton therapy: real-time prompt gamma imaging and microdosimetry
CERN/FIS-TEC/0019/2019
Principal investigator
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/09/30 RPC-PET - Uma nova tecnologia para imagiologia molecular simultânea de corpo inteiro com elevada sensibilidade e resolução
PTDC/SAU-BEB/104630/2008
Post-doc
Universidade de Coimbra, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 7 - 2011-2012
PEst-C/FIS/LA0007/2011
Post-doc
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2011/03/31 Participation in the RD51 collaboration: detector physics and patterned resistive plate chambers
CERN/FP/109355/2009
Post-doc
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/10/01 - 2010/03/31 Aplicações das Camaras de Placas Resistivas temporizadoras à FAE e à imagiologia de radioisótopos
CERN/FP/83524/2008
Post-doc
Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Crespo, Paulo; Caramelo, F.; Guerreiro, C.; Ferreira, N.. "Chapter 5: Radiation detectors and image formation". In Nuclear Medicine Physics, edited by Pedroso de Lima, J. J.. CRC Press - Taylor & Francis Group, 2010.
    Published
  2. Crespo, Paulo; Ferreira, N.; Guerreiro, C.; Botelho, M. F.; Costa, D. C.; Araújo, H.. "Chapter 6: Imaging methodologies". In Nuclear Medicince Physics, edited by Pedroso de Lima, J. J.. CRC Press - Taylor & Francis Group, 2010.
    Published
  3. Crespo, Paulo; Caramelo, F.; Guerreiro, C.; Ferreira, N.. "Capítulo 5: Detectores de radiação e produção de imagem". In Física em Medicina Nuclear, edited by Pedroso de Lima, J. J.. Imprensa da Universidade de Coimbra, 2008.
    Published
  4. Crespo, Paulo; Ferreira, N.; Guerreiro, C.; Botelho, M. F.; Costa, D. C.; Araújo, H.. "Capítulo 6: Métodos de imagem". In Física em Medicina Nuclear, edited by Pedroso de Lima, J. J.. Imprensa da Universidade de Coimbra, 2008.
    Published
Conference abstract
  1. Simões, Hugo; Ferreira Marques, Rui; Crespo, Paulo; Rachinhas, Paulo J. B. M.. "OrthoCT for assisting external-beam radiotherapy: 2D morphological image obtained experimentally without X-ray source rotation". Paper presented in 2018 MediNet Network Meeting, Belgrado, 2018.
    Published
  2. Simões, Hugo; Lopes, A. L.; Travassos, C.; Crespo, Paulo. "Abstract ID: 153 Monte Carlo simulation study of orthogonal ray imaging for monitoring head radiotherapy". 2017.
    Published • 10.1016/j.ejmp.2017.09.080
  3. Travassos, Carolina; Simões, Hugo; Barros, Mariana Alves; Crespo, Paulo; Lencart, Joana; Rachinhas, Paulo J. B. M.; Santos, Joao A. M.. "Experimental viability of the use of MV beams for orthogonal ray imaging". Paper presented in 2017 IEEE 5th Portuguese Meeting in Bioengineering (ENBENG), Coimbra, 2017.
    Published
  4. Lopes, Ana Luísa; Simões, Hugo; Crespo, Paulo; Barata, Joao A. S.; Barros, Mariana Alves; Lencart, Joana; Santos, Joao A. M.. "Simulation study of OrthoCT viability for monitoring lung/head/prostate irradiations". Paper presented in 2017 IEEE 5th Portuguese Meeting in Bioengineering (ENBENG), Coimbra, 2017.
    Published
  5. Simões, Hugo; Lopes, Ana Luísa; Travassos, Carolina; Crespo, Paulo. "Monte Carlo simulation study of orthogonal ray imaging for monitoring head radiotherapy". Paper presented in 2017 MCMA - International Conference on Monte Carlo Techniques for Medical Applications, Naples, Italy, 2017.
    Published
  6. Simões, Hugo; Crespo, Paulo. "A light-guide optimization for proof-of-principle of a megavoltage orthogonal ray imaging prototype". Paper presented in 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG), Porto, Portugal, 2015.
    Published • 10.1109/ENBENG.2015.7088818
  7. Simões, Hugo; Crespo, Paulo; Borrego, M.; Bravo, Isabel; Capela, Miguel; Cavaco, Ana; Marques, Rui Ferreira; et al. "Imagiologia de raios ortogonais para apoio à radioterapia: estudo de simulação de irradiação no pulmão e na cabeça com fantoma antropomórfico". Paper presented in Workshop sobre Justificação e Optimização das Exposições Médicas a Radiações Ionizantes, Lisboa, 2015.
    Published
  8. Simões, Hugo; Bravo, Isabel; Capela, Miguel; Cavaco, Ana; Marques, Rui Ferreira; Fonte, Paulo; Lencart, Joana; et al. "Imagiologia de raios ortogonais para apoio à radioterapia: estudo de simulação de irradiação no pulmão com fantoma antropomórfico". Paper presented in Física 2014 – 19a Conferência Nacional de Física da SPF, Lisboa, 2014.
    Published
  9. Ghithan, Sharif; Carmo, Sérgio J. C.; Marques, Rui Ferreira; Fraga, Francisco A. F.; Simões, Hugo; Alves, Francisco; Rachinhas, Paulo J. B. M.; Crespo, Paulo. "PET cyclotron based irradiation setup for proton radiobiology and radiophysiology". Paper presented in Física 2014 – 19a Conferência Nacional de Física da SPF, Lisboa, 2014.
    Published
  10. Cambraia Lopes, Patrícia; Simões, Hugo; Parodi, K.; Schaart, D. R.; Crespo, Paulo. "Prompt-gamma imaging by multi-slat collimators for monitoring proton treatment delivery: Monte Carlo study with an anthropomorphic phantom". Paper presented in Física 2014 – 19a Conferência Nacional de Física da SPF, Lisboa, 2014.
    Published
  11. Sousa, Sonia C. P.; Almeida, Jorge; Cavaleiro Miranda, Pedro; Salvador, Ricardo; Silvestre, Joao; Simões, Hugo; Crespo, Paulo. "Deep-brain transcranial magnetic stimulation with a system of coils immersed in conducting liquid". Paper presented in Física 2014 – 19a Conferência Nacional de Física da SPF, Lisboa, 2014.
    Published
  12. Simões, Hugo; Battaglia, Maria Cristina; Bellini, Vincenzo; Capela, Miguel; Cavaco, Ana; Cisbani, Evaristo; Do Carmo Lopes, Maria; et al. "Orthogonal ray imaging: from dose monitoring in external beam therapy to morphologic imaging with scanned megavoltage X-rays". Paper presented in 2013 IEEE 3rd Portuguese Meeting in Bioengineering (ENBENG), Braga, 2013.
    Published
  13. Cambraia Lopes, Patrícia; Simões, Hugo; Biegun, A. K.; Dendooven, P.; Oxley, D. C.; Parodi, K.; Schaart, D. R.; Crespo, Paulo; Pinto, Marco. "Monte-Carlo study on prompt-gamma imaging through multi-slat collimators: intrinsic performances with simple and anthropomorphic phantoms, apresentado". Paper presented in 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC), Seoul, Korea (South), 2013.
    Published
  14. Ghithan, Sharif; Carmo, Sérgio J. C.; Marques, Rui Ferreira; Fraga, Francisco A. F.; Simões, Hugo; Alves, Francisco; Crespo, Paulo. "Towards a high-dynamic dose-range irradiation setup for radiobiology/radiophysiology and other dosimetric studies at PET-dedicated cyclotrons". Paper presented in PTCOG 52 – Particle Therapy Co-Operative Group, Essen, Germany, 2013.
    Published
  15. Pires, S; Abrantes, AM; Laranjo, M; Serra, E; Goncalves, C; Crespo, P; Rocha Gonsalves, AM; Sarmento Ribeiro, AB; Botelho, MF. "Ascorbic acid and its potentiality as image agent and anticancer drug". Paper presented in EANM'08 - Annual Congress of the European Association of Nuclear Medicine, Munich, 2008.
    Published
Conference paper
  1. Simões, H.; Marques, R.F.; Rachinhas, P.J.B.M.; Wagner, A.; Crespo, P.. "Rotation-Free Scattered-Radiation Imaging with a Radiotherapy X-Ray Linac". 2018.
    10.1109/NSSMIC.2018.8824227
  2. Simoes, H.; Lopes, A.L.; Crespo, P.. "Ortho CT for tumor head irradiation: A simulation study". 2017.
    10.1109/NSSMIC.2016.8069473
  3. Travassos, C.; Simoes, H.; Crespo, P.; Barros, M.A.; Lencart, J.; Rachinhas, P.J.B.M.; Santos, J.A.M.. "Experimental characterization of megavoltage beams for orthogonal ray imaging". 2017.
    10.1109/NSSMIC.2016.8069472
  4. Lopes, A.L.; Simões, H.; Crespo, P.; Barata, J.A.S.; Lencart, J.; Santos, J.A.M.. "Impact of tumor contrast in orthogonal ray imaging: A prostate irradiation study". 2017.
    10.1109/NSSMIC.2016.8069392
  5. Simoes, H.; Barros, M.A.; Crespo, P.. "Orthoct for tumor lung irradiation: A simulation study". 2017.
    10.1109/NSSMIC.2016.8069391
  6. Martins, P; Blanco, A; Crespo, P; Marques, M F F; Marques, R F; Gordo, P M; Kajetanowicz, M; et al. "An ultra-high resolution preclinical positron emission tomography scanner". Paper presented in 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG), Porto, 2015.
    Published • 10.1109/enbeng.2015.7088828
  7. Couceiro, Miguel; Crespo, Paulo; Alberto Blanco Castro; Ferreira, Nuno Chichorro; Mendes, Luis; Lopes, Luis; Rui Ferreira Marques; Paulo Jorge Ribeiro da Fonte. "Expected Performance of a Positron Emission Tomography System with Time-of-Flight Information, Based on Resistive Plate Chamber Detectors". Paper presented in Física 2014 – 19a Conferência Nacional de Física e 24o Encontro Ibérico para o Ensino da Física, Lisboa, 2014.
    Published
  8. Sousa, Sonia C. P.; Almeida, Jorge; Cavaleiro Miranda, Pedro; Salvador, Ricardo; Silvestre, Joao; Simoes, Hugo; Crespo, Paulo. "Optimization of multiple coils immersed in a conducting liquid for half-hemisphere or whole-brain deep transcranial magnetic stimulation: A simulation study". Paper presented in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014.
    Published • 10.1109/embc.2014.6943647
  9. Simoes, H.; Dias Silva, M.; Vieira Ferreira, C.; Jesus, L.; Oliveira, H.; Miranda, P.C.; Salvador, R.; Crespo, P.; Silvestre, J.. "Experimental demonstration of induction by means of a transcranial magnetic stimulator coil immersed in a conducting liquid". Paper presented in ENBENG 2013, 2013.
    10.1109/ENBENG.2013.6518402
  10. Martins, P.; Blanco, A.; Crespo, P.; Ferreira Marques, M.F.; Marques, R.F.; Gordo, P.M.; Kajetanowicz, M.; et al. "Achieving 0.4-mm FWHM spatial resolution with an RPC-based small-animal PET prototype". 2013.
    10.1109/NSSMIC.2013.6829105
  11. Simões, H.; Bravo, I.; Capela, M.; Cavaco, A.; Ferreira Marques, R.; Fonte, P.; Lencart, J.; et al. "Observation of tumor morphological changes in lung irradiation with orthogonal ray imaging: RTmonitoring - A simulation study". 2013.
    10.1109/NSSMIC.2013.6829313
  12. Simoes, H.; Ghithan, S.; Loureiro, M.; Crespo, P.. "Characterization of GSO:Ce phosphorescence after low-dose-rate gamma-ray irradiation". 2013.
    10.1109/NSSMIC.2013.6829626
  13. Ghithan, S.; Do Carmo, S.J.C.; Marques, R.F.; Fraga, F.A.F.; Simoes, H.; Alves, F.; Crespo, P.. "Fast and precise verification of proton beam position, range, and dose using a plastic scintillator at PET-dedicated cyclotrons". 2013.
    10.1109/NSSMIC.2013.6829604
  14. Simoes, Hugo; Battaglia, Maria Cristina; Capela, Miguel; Lopes, Maria do Carmo; Crespo, Paulo. "Rotation-free computed tomography with orthogonal ray imaging: First millimetric experimental results". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551828
  15. Ghithan, Sharif; Alves, Francisco; Carmo, Sergio; Marques, Rui Ferreira; Fraga, Francisco; Simoes, Hugo; Crespo, Paulo. "Towards a high-dynamic dose-range irradiation setup for radiobioloy and radiophysiology". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551307
  16. Martins, Paulo; Crespo, Paulo; Ferreira Marques, Rui; Kajetanowicz, Marcin; Korcyl, Grzegorz; Lopes, Luis; Michel, Jan; et al. "Experimental sub-millimeter resolution with a small-animal RPC-PET prototype". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551863
  17. Cambraia Lopes, P.; Pinto, M.; Simoes, H.; Biegun, A. K.; Dendooven, P.; Oxley, D. C.; Parodi, K.; Schaart, D. R.; Crespo, P.. "Optimization of collimator designs for real-time proton range verification by measuring prompt gamma rays". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551886
  18. Battaglia, Maria Cristina; Simoes, Hugo; Bellini, Vincenzo; Cisbani, Evaristo; Lopes, Maria do Carmo; Crespo, Paulo. "Orthogonal ray imaging with megavoltage beams: Simulated results with an anthropomorphic phantom". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551884
  19. Martins, Paulo; Couceiro, Miguel; Ferreira, Nuno C.; Ferreira Marques, Rui; Fonte, Paulo; Mendes, Luis; Crespo, Paulo. "On lesion detectability by means of 300ps-FWHM TOF whole-body RPC-PET: An experiment-based simulation study". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551555
  20. Simoes, Hugo; Battaglia, Maria Cristina; Capela, Miguel; Cavaco, Ana; Lopes, Maria do Carmo; Rachinhas, Paulo J.B.M.; Soares, Paula; Simoes, PauloC.P.S.; Crespo, Paulo. "LYSO scintillators coupled to phototransistors for orthogonal ray imaging: Experimental results at 4 and 6-MV linacs". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551885
  21. Ghithan, Sharif; Simoes, Hugo; Alves, Francisco; Carmo, Sergio; Cunha, Micaela; Marques, Rui Ferreira; Fraga, Francisco; Pinto, Marco; Crespo, Paulo. "Preliminary characterization of the external proton beam from a PET cyclotron for use in neutron and proton radiobiology and other dosimetric studies". Paper presented in ENBENG 2012, 2012.
    10.1109/enbeng.2012.6331362
  22. Dias Silva, Marilia; Ferreria, Carina Vieira; Oliveira, Holder; Fonte, Paulo; Jesus, Luis; Salvador, Ricardo; Silvestre, Joao; Crespo, Paulo. "Multiple coils in a conducting liquid for deep and whole-brain transcranial magnetic stimulation. II. Multiple-frequency excitation". Paper presented in ENBENG 2012, 2012.
    10.1109/enbeng.2012.6331375
  23. Oliveira, Helder; Dias Silva, Marilia; Ferreira, Carina Vieira; Fonte, Paulo; Jesus, Luis; Salvador, Ricardo; Silvestre, Joao; Crespo, Paulo. "Multiple coils in a conducting liquid for deep and whole-brain transcranial magnetic stimulation. I. Single-frequency excitation". Paper presented in ENBENG 2012, 2012.
    10.1109/enbeng.2012.6331374
  24. Martins, P.; Blanco, A.; Caramelo, F.; Couceiro, M.; Ferreira, N.C.; Ferreira Marques, R.; Fonte, P.; Mendes, L.; Crespo, P.. "A direct time-of-flight reconstruction for whole-body single-bed RPC-PET: Results from lesion and anthropomorphic simulated data". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6152701
  25. Simões, H.; Pinto, M.; Cunha, M.; Gonçalves, J.; Sampaio, L.; Ferreira, R.J.; Saraiva, H.M.; et al. "Dose-free monitoring of radiotherapy treatments with scattered photons: First experimental results at a 6-MV Linac". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6153827
  26. Biegun, A.K.; Seravalli, E.; Cambraia Lopes, P.; Rinaldi, I.; Pinto, M.; Oxley, D.C.; Dendooven, P.; et al. "Range and density variations monitoring during proton therapy based on time-of-flight detection of prompt gamma radiation". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6152641
  27. Cunha, M.; Pinto, M.; Ferreira, B.; Lopes, M.D.C.; Fonte, P.; Crespo, P.. "Dose-free monitoring of radiotherapy treatments with scattered photons: Concept and simulation study". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6153645
  28. Cunha, M.; Pinto, M.; Alves, F.; Crespo, P.; Marques, R.F.. "Radiobiology with cyclotron proton beams: A viability study". Paper presented in 2010 IEEE NSS/MIC, 2010.
    10.1109/NSSMIC.2010.5874028
  29. Makinaga, A.; Rusev, G.; Schwengner, R.; Do¨nau, F.; Beyer, R.; Bemmerer, D.; Crespo, P.; et al. "Cross section measurement on 139-La below neutron separation energy". Paper presented in AIP, 2010.
    10.1063/1.3455936
  30. Crespo, P.; Reis, J.; Couceiro, M.; Blanco, A.; Ferreira, N.C.; Marques, R.F.; Fonte, P.. "Whole-body single-bed time-of-flight RPC-PET: Simulation of axial and planar sensitivities with NEMA and anthropomorphic phantoms". Paper presented in 2009 IEEE NSS/MIC, 2009.
    10.1109/NSSMIC.2009.5401775
  31. Shakirin, G.; Crespo, P.; Enghardt, W.. "On the optimum strategy for subsets based reconstruction of in-beam PET data". Paper presented in 2008 IEEE NSS/MIC, 2008.
    10.1109/NSSMIC.2008.4774101
  32. Shakirin, G.; Crespo, P.; Fiedler, F.; Wagner, A.; Enghardt, W.. "Optimum voxel size for reconstruction of In-Beam Pet data". Paper presented in 2008 IEEE NSS/MIC, 2008.
    10.1109/NSSMIC.2008.4774377
  33. Shakirin, G.; Crespo, P.; Braess, H.; Enghardt, W.. "Influence of the time of flight information on the reconstruction of in-beam PET data". Paper presented in 2007 IEEE NSS/MIC, 2007.
    10.1109/NSSMIC.2007.4437086
  34. Fiedler, F.; Crespo, P.; Parodi, K.; Sellesk, M.; Enghardt, W.. "The feasibility of in-beam PET for therapeutic beams of3He". Paper presented in 2005 IEEE NSS/MIC, 2005.
    10.1109/NSSMIC.2005.1596907
  35. Crespo, P.; Barthel, T.; Frais-Kölbl, H.; Griesmayer, E.; Heidel, K.; Parodi, K.; Pawelke, J.; Enghardt, W.. "Suppression of random coincidences during in-beam PET measurements". 2004.
  36. Crespo, P.; Kapusta, M.; Pawelke, J.; Moszynski, M.; Enghardt, W.. "First in-beam PET imaging with LSO/APD-array detectors". Paper presented in 2003 IEEE NSS/MIC, 2003.
    10.1109/nssmic.2003.1352251
  37. Kapusta, M.; Crespo, P.; Moszynski, M.; Enghardt, W.; Szawlowski, M.; Zhou, B.L.; Wolski, D.. "Evaluation of LAAPD arrays for high-resolution scintillator matrices readout". 2001.
  38. Lauckner, K.; Crespo, P.; Enghardt, W.; Pawelke, J.; Kraft, G.. "An LSO-based scanner for in-beam PET: A feasibility study". Paper presented in 2000 IEEE NSS/MIC, 2000.
  39. Crespo, P.; van der Marel, J.; Chepel, V.; Lopes, M.I.; Santos, Dinis; Janeiro, L.; Solovov, V.; Ferreira Marques, R.; Policarpo, A.J.P.L.. "Pulse processing for the PET liquid xenon multiwire ionisation chamber". Paper presented in 2008 IEEE NSS/MIC, 1998.
Journal article
  1. Miguéis, F.; Casaña, J.V.; García-Fernández, D.; Hueso-González, F.; Llosá, G.; Prieto, A.F.; Regueiro, P.V.; et al. "Sensitivity of coaxial prompt gamma-ray monitoring in heterogeneous geometries: A Monte Carlo simulation study". Radiation Physics and Chemistry 232 (2025): 112639. https://doi.org/10.1016/j.radphyschem.2025.112639.
    Published • 10.1016/j.radphyschem.2025.112639
  2. John P. Cesar; Firas Abouzahr; Paulo Crespo; Michael Gajda; Alex Kuo; Osama Mawlawi; Andrey Morozov; et al. "First PET Studies of a FLASH Proton Beam: Summary and Future Prospects". Bio-Algorithms and Med-Systems (2024): https://doi.org/10.5604/01.3001.0054.9140.
    Published • 10.5604/01.3001.0054.9140
  3. Guerreiro, D R; Saraiva, J G; Peralta, L; Rodrigues, C; Rovituso, M; van der Wal, E; R Schaart, Dennis; et al. "Novel Bragg peak characterization method using proton flux measurements on plastic scintillators". Physics in Medicine & Biology 69 22 (2024): 225005. http://dx.doi.org/10.1088/1361-6560/ad8da0.
    Published • 10.1088/1361-6560/ad8da0
  4. Simões, Hugo; Lopes, Luis; Rachinhas, Paulo J. B. M.; Crespo, Paulo. "Multislit gamma camera for external beam radiotherapy assistance: Experimental proof of concept". Advances in Radiotherapy & Nuclear Medicine 2 3 (2024): 4099. https://doi.org/10.36922/arnm.4099.
    Published • 10.36922/arnm.4099
  5. Abouzahr, F.; Cesar, J.P.; Gajda, M.; Kuo, A.S.; Lang, K.; Liu, J.; Ojha, A.; et al. "Ortho-positronium Detection with a High-Resolution PET Scanner". Acta Physica Polonica B Proceedings Supplement 17 7 (2024): 1. https://doi.org/10.5506/aphyspolbsupp.17.7-a1.
    Published • 10.5506/aphyspolbsupp.17.7-a1
  6. Abouzahr, F; Cesar, J P; Crespo, P; Gajda, M; Hu, Z; Klein, K; Kuo, A S; et al. "The first probe of a FLASH proton beam by PET". Physics in Medicine & Biology 68 23 (2023): 235004. http://dx.doi.org/10.1088/1361-6560/ad0901.
    Published • 10.1088/1361-6560/ad0901
  7. Abouzahr, F; Cesar, J P; Crespo, P; Gajda, M; Hu, Z; Kaye, W; Klein, K; et al. "The first PET glimpse of a proton FLASH beam". Physics in Medicine & Biology 68 12 (2023): 125001. http://dx.doi.org/10.1088/1361-6560/acd29e.
    Published • 10.1088/1361-6560/acd29e
  8. Fonte, Paulo; Lopes, Luís; Alves, Rui; Carolino, Nuno; Crespo, Paulo; Couceiro, Miguel; Cunha, Orlando; et al. Corresponding author: Fonte, Paulo. "An RPC-PET brain scanner demonstrator: First results". Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 1051 (2023): 168236. http://dx.doi.org/10.1016/j.nima.2023.168236.
    Published • 10.1016/j.nima.2023.168236
  9. Morozov, A.; Simões, H.; Crespo, P.. "Distal edge determination precision for a multi-slat prompt-gamma camera: A comprehensive simulation and optimization of the detection system". Physica Medica 84 (2021): 85-100. http://dx.doi.org/10.1016/j.ejmp.2021.03.028.
    Published • 10.1016/j.ejmp.2021.03.028
  10. M. P. Pascoa; J. M. Maia; N. Auricchio; R. M. Curado da Silva; P. Crespo; S. J. C. do Carmo; M. Moita; F. Alves; E. Caroli. "Orbit-Like Proton Radiation Sensitivity of CdTe Detectors: Evaluation of Mobility-Lifetime Products and Spectroscopic Properties". IEEE Transactions on Nuclear Science 66 9 (2019): 2063-2071. https://doi.org/10.1109/TNS.2019.2935119.
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    Published

Intellectual property

Patent
  1. Crespo, Paulo; Heidel, K.; Enghardt, W.; Fiedler, F.. Corresponding author: Crespo, Paulo. 2006. "Verfahren zur Kontrolle von Bestrahlungen an Bestrahlungseinrichtungen mit in-beam Positronenemissionstomographen". Germany.
    Granted/Issued
  2. Crespo, Paulo; Enghardt, W.; Parodi, K.; Pawelke, J.. Corresponding author: Enghardt, W.. 2004. "Verfahren zur Korrektur der beim Monitoring der strahlentherapeutischen Behandlung mittels in-beam Positronen-Emissions-Tomographie erhaltenen Messwerte". Germany.
    Granted/Issued
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - 2024 Verificação do alcance de protões para a irradiação de fantomas antropomórficos implementados em simulações de Monte Carlo com o Geant4
Supervisor
 Master thesis in Medical Physics (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2022 - 2023 In vivo cortical and subcortical recording of eye movements-related activity in Parkinson's disease
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Unidade Local de Saúde de Coimbra, Portugal
2022 - 2023 Fast algorithm of simulation positron emission species generation for a multi-beamlet proton therapy treatment plans
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2022 - 2023 Optimization of a device for deep-brain transcranial magnetic stimulation via simulations
Supervisor
 Master thesis in Physics Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2021 - 2022 Simulação de uma câmara multi-fatia de raios gama para determinação do alcance do feixe de protões em irradiação pélvica
Supervisor
 Master thesis in Physics Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2021 - 2022 Monte Carlo simulation of an in-beam TOF-PET system for range monitoring in proton therapy
Supervisor
 Master thesis in Medical Physics (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2021 - 2022 Monitorização de terapia com protões com imagiologia por raios gama ortogonais: Estudo da irradiação na cabeça
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2018 - 2019 Automation of co-registration of pre-clinical RPC-PET images with animal MRI
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2013/09 - 2018/07 Demonstração de um dispositivo de imagiologia por raios ortogonais para apoio à radioterapia externa de fotões
Supervisor
 Doutoramento em Engenharia Biomédica (PhD)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Unidade Local de Saúde de Coimbra, Portugal
2017 - 2018 Towards and integrated electrocardiography system for digital stethoscopes
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Instituto de Telecomunicações Lisboa, Portugal
2012 - 2017/10 Time-resolved imaging of secondary gamma ray emissions for in vivo monitoring of proton therapy: methodological and experimental feasibility studies
Co-supervisor
 Physics (PhD)
Technische Universiteit Delft, Netherlands

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

UniversitätsKlinikum Heidelberg Heidelberger Ionenstrahl-Therapiezentrum, Germany
2015 - 2016 Impacto do contraste tumoral em imagiologia por raios ortogonais
Supervisor
 Master thesis in Biomedical Sciences (Master)
Universidade da Beira Interior, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2015 - 2016 Caracterização experimental de feixes de megavoltagem para imagiologia por raios ortogonais
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Unidade Local de Saúde de Coimbra, Portugal
2015 - 2016 Medida de dose em fantomas submetidos a radiação de megavoltagem para imagiologia por raios ortogonais
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2014 - 2015 Development of a new, improved deep-brain transcranial magnetic stimulator (TMS)
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2014 - 2015 Phase dependent motor excitability TMS applied in different tACS phases
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Eberhard Karls Universität Tübingen, Germany
2010/10 - 2014/12 Development of a PET cyclotron based irradiation setup for proton radiobiology
Supervisor
 Doutoramento em Engenharia Física (PhD)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2010 - 2014/12 Imaging techniques in RPC-PET
Supervisor
 Doutoramento em Física (PhD)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2013 - 2014 Optimização de um dispositivo para estimulação magnética transcraniana profunda
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal
2011 - 2012 Monte Carlo simulation of primary and secondary particle yield during selected radiotherapy treatments
Supervisor
 Master in Physics (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Università degli Studi di Catania, Italy
2009 - 2010 Radiobiology with proton cyclotron beams: A viability study.
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2009 - 2010 Implementation of a cyclotron-based neutron beam line: A viability study
Supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2007 - 2008 Citotoxicidade da vitamina C em células tumorais: estudos in-vitro e in-vivo através de métodos bioquímicos e de imagiologia nuclear
Co-supervisor
 Master thesis in Biomedical Engineering (Master)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
2007 - 2008 Simulação da biodistribuição, aniquilação e escape de fotões PET no corpo humano
Supervisor
 Degree thesis in Biomedical Engineering (Degree)
Universidade de Coimbra Departamento de Física, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Pólo de Coimbra, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09/11 - 2023/12/15 Instrumentação para Imagiologia Médica Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2021/09/13 - 2023/12/15 Física Aplicada Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra, Portugal
2023/02/06 - 2023/05/26 Tópicos de Física Moderna Engenharia Informática (Licenciatura) Universidade de Coimbra, Portugal
2022/02/07 - 2023/05/26 Segurança e Proteção Radiológica em Ambiente Hospitalar Física Médica (Mestrado) Universidade de Coimbra, Portugal
2022/02/07 - 2022/05/27 Ondas e Ótica Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2021/09/13 - 2021/12/17 Laboratórios I Licenciatura em Física (Licenciatura) Universidade de Coimbra, Portugal
2021/09/13 - 2021/12/17 Termodinâmica e Processos de Transferência Engenharia Biomédica (Licenciatura) Universidade de Coimbra, Portugal
2016/09/12 - 2021/12/17 Física II Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2014/09/08 - 2021/12/17 Eletromagnetismo Engenharia Eletrotécnica e de Computadores (Mestrado integrado) Universidade de Coimbra, Portugal
2018/09/10 - 2020/12/18 Técnicas Laboratoriais de Física Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2014/09/08 - 2020/12/18 Instrumentação para Imagiologia Médica Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra, Portugal
2016/09/12 - 2016/12/16 Complementos de Física Licenciatura em Bioquímica (Licenciatura) Universidade de Coimbra, Portugal
2014/09/08 - 2016/12/16 Física Geral II Licenciatura em Química (Licenciatura) Universidade de Coimbra, Portugal
2014/09/08 - 2016/12/16 Física Aplicada Ciências Farmacêuticas (Mestrado integrado) Universidade de Coimbra, Portugal
2016/02/08 - 2016/05/31 Seminário II em Física Nuclear e das Partículas Programa Doutoral em Física (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2015/09/14 - 2015/12/18 Seminário I em Física Nuclear e das Partículas Programa Doutoral em Física (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2014/09/08 - 2014/12/12 Mecânica e Ondas Engenharia Eletrotécnica e de Computadores (Mestrado integrado) Universidade de Coimbra, Portugal
2014/09/08 - 2014/12/12 Física Laboratorial I Licenciatura em Física (Licenciatura) Universidade de Coimbra, Portugal
2014/09/08 - 2014/12/12 Física Geral I Engenharia Civil (Mestrado integrado) Universidade de Coimbra, Portugal
Distinctions

Other distinction

2006 Top 10 article of the year in Physics in Medicine and Biology according to the reviewers
IOP - Institute of Physics, United Kingdom