Cecília Maria Pereira Rodrigues (DC18-39A7-F287)

Curriculum Vitae

Cecília Maria Pereira Rodrigues

Cecilia M.P. Rodrigues completed her degree in Pharmaceutical Sciences at the University of Lisbon in 1992, and later obtained her PhD in Pharmacy (Biochemistry) in 1996 from the same institution, after completing PhD training at the University of Cincinnati, OH, USA under the guidance of K.D.R. Setchell. She then pursued postdoctoral work at the University of Minnesota, MN, USA with C.J. Steer. Since 2009, she has held the position of Full Professor at the Faculty of Pharmacy, University of Lisbon. Rodrigues has published close to 300 indexed peer-reviewed papers, 20 book chapters and 4 global coverage patents (h-index 70 and ca. 24,000 citations in Scopus). Her research interests are discovering novel mechanism-based molecular targets for therapeutic intervention and diagnosis in inflammatory, neurodegenerative and oncogenic diseases. Rodrigues leads a laboratory that focuses on signalling pathways involved in cell death, differentiation and proliferation, as well as interorgan communication by bile acids and other biomolecules. She uses relevant experimental models and patient samples, and employs genetic and pharmacological strategies to interrogate transcriptomics and proteomics profiles. Her research has developed promising technologies protected by global patents and explored by spin-offs that have moved to clinical trials worldwide. Rodrigues has held leadership positions, including founder and Head of Department (2021; 2011-18) at the Faculty of Pharmacy, University of Lisbon, and Director of the Research Institute for Medicines (2013-20). Currently, she is vice-rector for Research and Innovation at the University of Lisbon (2021-25). She created and currently directs the PhD Programme in Medicines and Pharmaceutical Innovation (2015-present) and the Master Course in Biopharmaceutical Sciences (2010-present). She has supervised close to 100 PhD students and postdoctoral scientists, and 80 MSc students. Rodrigues has received awards, including the EASL Sheila Sherlock Award in 2000 and most recently the Krebs Medal FENS in 2022. She has been invited to speak at international conferences and has served on various national and international editorial (Hepatology, Journal of Hepatology) and grant review (FCT Portugal, A3ES Portugal, BMBF Germany, MRC UK, ARN and CNRS France, ISCIII Spain, MOH Italy, and SFI Ireland) boards. Rodrigues has secured independent funding from public competitive sources and/or through private investment, amounting to ca. 20 M€. She has a background in technology transfer, technology commercialization and academic-industrial collaborations, including with AstraZeneca Open Innovation, UK. ORCID ID: 0000-0002-4829-754X; Scopus Author ID: 7202508239; Researcher ID: M-3572-2013; Ciência ID DC18-39A7-F287.

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Identification

Personal identification

Full name: Cecília Maria Pereira Rodrigues

Citation names

Rodrigues, CMP
Rodrigues, CM
Rodrigues, C

Author identifiers

Ciência ID: DC18-39A7-F287
ORCID iD: 0000-0002-4829-754X
Researcher Id: M-3572-2013
Scopus Author Id: 7202508239

Email addresses

cmprodrigues@ff.ulisboa.pt (Professional)

Telephones

Fax

217946491 (Professional)

Telephone

217946490 (Professional)

Addresses

iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa. Av. Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

https://imed.ulisboa.pt/cv/cecilia-maria-pereira-rodrigues/ (Scholar)
http://www.imed.ulisboa.pt/ (Scholar)
http://www.ff.ul.pt/ (Scholar)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)
Spanish; Castilian	Upper intermediate (B2)	Upper intermediate (B2)	Intermediate (B1)	Upper intermediate (B2)	Upper intermediate (B2)

Education

	Degree	Classification
2005/09/13 Concluded	Pharmacy (Título de Agregado) Major in Biological Sciences Universidade de Lisboa Faculdade de Farmácia, Portugal "Modulation of Apoptosis by Bile Acids. Lição de síntese apresentada em provas de habilitação ao título de Agregada no 2º Grupo de Ciências Biológicas da Faculdade de Farmácia da Universidade de Lisboa" (THESIS/DISSERTATION)	Approved
1996/03/01 Concluded	Pharmacy (Doutoramento) Major in Biochemistry Universidade de Lisboa Faculdade de Farmácia, Portugal "The metabolism of ursodeoxycholic acid: basic and clinical studies" (THESIS/DISSERTATION)	Approved with Distinction and Honor
1992 Concluded	Pharmaceutical Sciences (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal "n/a" (THESIS/DISSERTATION)	Excellent: Eighteen (18/20)

Affiliation

Science

	Category Host institution	Employer
1996 - 1999	Postdoc (Research)	University of Minnesota, United States
	University of Minnesota, United States
1992 - 1995	Researcher (Research)	University of Cincinnati, United States

Teaching in Higher Education

	Category Host institution	Employer
2009 - Current	Full Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2009	Associate Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2006	Assistant Professor (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
1999 - 2004	Assistant (University Teacher)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

	Category Host institution	Employer
2021/10/01 - 2025/09/30	Vice-Rector	Universidade de Lisboa, Portugal
	Universidade de Lisboa, Portugal
2021/01/01 - 2021/10/01	Organic Unit President	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2020	Organic Unit Director	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007 - 2020	Manager of Laboratory, Institute, Museum, Centre or Observatory	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2011 - 2018	Organic Unit President	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Projects

Grant

	Designation	Funders
1996 - 1999	Molecular Studies of Ursodeoxycholic Acid Therapeutic Effects, University of Minnesota, Minneapolis, MN, USA Bolsa BPD FCT Post-doc Fellow University of Minnesota, United States	Fundação para a Ciência e a Tecnologia Concluded
1992 - 1995	The Metabolism of Ursodeoxycholic Acid: Basic and Clinical Studies, University of Cincinnati, Cincinnati, OH, USA Bolsa BD FCT PhD Student Fellow University of Cincinnati Academic Health Center, United States	Fundação para a Ciência e a Tecnologia Concluded
1990 - 1992	Centro de Metabolismos e Genética, University of Lisbon, Lisbon, Portugal Bolsa BII Instituto Nacional de Investigação Científica (INIC) Scientific Initiation Fellow Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2024/01/01 - Current	Total of ca. 70 projects (Principal Investigator in >35, generating ca. 20M Euro) Principal investigator
2022/01/01 - 2024/12/31	Translating RIPK3 Signalling into Application in Metabolic Liver Disease PTDC/MED-FAR/3492/2021 Principal investigator Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal	Ongoing
2021/11/01 - 2024/10/30	RIPK3 Biology and Targeting in Metabolic Liver Disease LCF/PR/HR21/52410028 Principal investigator Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017 - 2024	LITMUS - Liver Investigation: Testing Marker Utility in Steatohepatitis IMI2 116125-2 H2020 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Commission Ongoing
2017/01 - 2021/12	FOIE GRAS - Bioenergetic remodeling in the pathophysiology and treatment of non-alcoholic fatty liver disease H2020 MSCA-ITN-ETN 2016 European Commission Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Commission Ongoing
2018 - 2021	LiverBTT - Non-alcoholic Fatty Liver Disease: Emerging Biomarkers, Targets and Therapies PTDC/MED-FAR/29097/2017 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e Tecnologia Ongoing
2018 - 2021	Exosomal Fat-Liver Axis in Non-Alcoholic Fatty Liver Disease: Function and Modulation PTDC/MED-PAT/31882/2017 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Metabolic Control of Neural Repair by Diet and Gut Microbiome during Aging PTDC/MED-NEU/29650/2017 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Nanoformulated Hybrid Molecules For Specific Targeting Melanoma Metastasis PTDC/MED-QUI/31721/2017 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Drug discovery for p53 PPi-targets PTDC/QUI-QOR/29664/2017 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Targeting aquaporin-3 as a novel therapeutic approach for melanoma PTDC/BTM-SAL/28977/2017 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018 - 2021	Tricks or Treats? Toward Selective Organoruthenium(II) Glycoconjugated Anticancer Agents PTDC/MED-QUI/31468/2017 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017 - 2021	mitoFOIE GRAS - Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease H2020-MSCA-RISE-2016 734719 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	H2020-MSCA-RISE-2016 Ongoing
2017 - 2020	POINT4PAC - Precision Oncology by Innovative Therapies and Technologies COMPETE 2020 SAICTPAC/0019/2015 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017 - 2019	Targeting the NAFLD-HCC continuum with bile acid-activated receptor agonists and microRNAs Intercept 2017 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Intercept Pharmaceuticals Concluded
2016 - 2019	New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer PTDC/BIM-MEC/0895/2014 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015 - 2018	High Throughput Screening With AstraZeneca's Compound library AZ HTS 2015 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	AstraZeneca UK Ltd Concluded
2015 - 2017	Role of Mitofusin 2 in Non-Alcoholic Fatty Liver Disease and Targeting by microRNAs Gilead Science International 2015 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Gilead Sciences International Ltd Concluded
2013 - 2016	Treat Liver Disease by Targenting Hepatocyte Necroptosis HMSP-ICT/0018/2011 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Harvard Medical School Fundação para a Ciência e a Tecnologia Concluded
2013 - 2015	New Therapeutic Targets to Control Viral Hepatitis Gilead Science 2013 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Gilead Sciences Lda Concluded
2013 - 2015	Driving Mitochondrial Effectors of Apoptosis Toward Neural Differentiation info:eu-repo/grantAgreement/FCT/3599-PPCDT/124457/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2015	NecroPT - Targeting Hepatocyte Necroptosis to Treat Liver Diseases 119842 Provided by PTCRIS: 119842 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2015	Interaction of bile acids with lipid membranes: creating a shield or bursting the bubble. info:eu-repo/grantAgreement/FCT/3599-PPCDT/119494/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2015	Oceanic Treasures - Oceanic sediments from the Madeira Archipelago: a new source of innovative and bioactive compounds PTDC/QUI-QUI/119116/2010 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2015	Functional compatibility of the replication complex as determinant of virulence in influenza virus info:eu-repo/grantAgreement/FCT/3599-PPCDT/122780/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2015	Aiming at microRNA-21 and bile acid activated receptors in non-alcoholic fatty liver disease pathogenesis: two bullets for one murder? PTDC/BIM-MEC/0873/2012 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2014	Preventing Memory Loss in Alzheimer's Disease: Underlying Mechanisms and Therapeutic Targets of Tauroursodeoxycholic Acid 117877 Provided by PTCRIS: 117877 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2014	Modulation of amyloid beta-induced neuronal toxicity via JNK: a novel role for tauroursodeoxycholic acid info:eu-repo/grantAgreement/FCT/3599-PPCDT/112636/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2013	Targeting microRNA-34, a Potential Link between Apoptosis and Nonalcoholic Fatty Liver Disease Pathogenesis info:eu-repo/grantAgreement/FCT/3599-PPCDT/111930/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2013	The influence of bile acids in malaria hepatic infection PTDC/SAU-MII/099118/2008 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2012	Prevalence and severity of fatty liver in morbid obesity: correlation and mechanisms related with the role of ectopic fat in insulin resistance info:eu-repo/grantAgreement/FCT/3599-PPCDT/100878/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Understanding microRNA Profiles and Cellular Functions in Colorectal Cancer 99162 Provided by PTCRIS: 99162 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Exploring New Roles for Endogenous Bile Acids and microRNAs in Modulating Liver Regeneration info:eu-repo/grantAgreement/FCT/3599-PPCDT/102099/PT Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2011	Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network) 109361 Provided by PTCRIS: 109361 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2011	Modulation of liver regeneration by bile acids: role of miRNAs SPG 2008 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Sociedade Portuguesa de Gastrenterologia Concluded
2008 - 2011	Linking Fibrillogenesis and the Apoptosis Induced by Amyloid-beta Mutant Peptides 67922 Provided by PTCRIS: 67922 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2011	Membrane receptors and mediators involved in plastic changes induced by neuronal insults: implications for neuroprotection Provided by PTCRIS: 68607 68607 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2010	Neurodegeneration in Alzheimer’s Disease Transgenic Mice: Role of Apoptosis and its Modulation 67912 Provided by PTCRIS: 67912 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2009	Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity Provided by PTCRIS: 82406 82406 Researcher Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2009	Studies on genetic and physiological characterization of sheep adaptation to food restriction Provided by PTCRIS: 82574 82574 Researcher Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Universidade de Coimbra Concluded
2007 - 2009	Correlation between aggregation, fibril formation and apoptosis induced by APP missense mutations Pfizer 2007 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Pfizer Biofarmacêutica Sociedade Unipessoal Lda Concluded
2007 - 2009	Isolation, characterization and application of a unique population of liver derived stem cells ROCHE 2017 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Roche Farmaceutica Quimica Lda Concluded
2004 - 2009	Apoptosis and inflammatory response in colorectal carcinogenesis: interaction between p53, ß-catenin and TGFß pathways in prognosis and resistance to therapy FCG/68796/2004 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação Calouste Gulbenkian Concluded
2007 - 2008	Tauroursodeoxycholic Acid Protection of Compression Spinal Cord Injury: Targeting Cell Survival Cascades 82487 Provided by PTCRIS: 82487 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005 - 2008	Bile Acid Mediated Inhibition of Neuronal Apoptosis 82322 Provided by PTCRIS: 82322 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2006 - 2007	Basic cellular mechanisms of anti-apoptotic signaling by bile acids FCG Estímulo 2005 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação Calouste Gulbenkian Concluded
2005 - 2007	Basic mechanisms of apoptosis in cells expressing an Alzheimer’s disease-associated double mutation FLAD/L-V-595/2004 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação Luso-Americana Concluded
2003 - 2007	Signaling events in tauroursodeoxycholic acid protection of amyloid ß-peptide-induced neuronal death POCTI/BCI/44929/2002 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2003 - 2005	Colorectal cancer and apoptosis: nutrition and cellular metabolism as risk factors SPG2002 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Sociedade Portuguesa de Gastrenterologia Concluded
2002 - 2004	Pathogenic mechanisms of injury in human alcoholic and non-alcoholic steatohepatitis: from oxidative stress to cell death by apoptosis SPGG2001 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Sociedade Portuguesa de Gastrenterologia Concluded
2000 - 2002	Role of mitochondria in bile acid-, bilirubin- and amyloid ß-peptide-induced apoptosis and protective effect of ursodeoxycholic acid and its conjugates EASLFellow2000 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Association for the Study of the Liver Concluded
1999 - 2001	Mechanisms of cell injury by glycochenodeoxycholic acid, bilirubin, and ß-amyloid. Role of ursodeoxycholic acid in preventing apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation PRAXIS/C/SAU/14311/98 Principal investigator Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Rodrigues, CMP; Rodrigues, Cecília. Systems Medicine: Integrative, Qualitative and Computational Approaches (Olaf Wolkenhauer, Ed.; Cecilia Rodrigues, section Ed.). Elsevier Science. 2020. In press • Editor
Book chapter	Simão, A.L.; Borralho, P.M.; Steer, C.J.; Castro, R.E.; Rodrigues, C.M.P.. "Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein: Analyses of miRNA and Protein Expression". 1-15. 2021. 10.1007/978-1-0716-1433-4_1 Simão, A.L.; Borralho, P.M.; Steer, C.J.; Castro, R.E.; Rodrigues, C.M.P. (DC18-39A7-F287). "Isolation of mitochondria from liver and extraction of total RNA and protein – analyses of miRNA and protein expression". In Mitochondrial Regulation: Methods and Protocols. Methods in Molecular Biology. Springer, 2020. In press Pinheiro, M.; Rodrigues, C.M.P. (DC18-39A7-F287). "Systems Medicine Overview: Metabolic and Cardiovascular Disease". In Systems Medicine: Integrative, Qualitative and Computational Approaches. Elsevier Science, 2020. In press Afonso, M.B.; Rodrigues, C.M.P.. "Necrosome formation and necroptosis in experimental cholestasis". In Methods in Molecular Biology, 149-162. Humana Press Inc., 2019. Published • 10.1007/978-1-4939-9420-5_10 Sousa, T.; Castro, R.E.; Coutinho, A.; Rodrigues, C.M.P.; Prieto, M.; Fernandes, F.. "Measuring the impact of bile acids on the membrane order of primary hepatocytes and isolated mitochondria by fluorescence imaging and spectroscopy". In Methods in Molecular Biology, 99-115. Humana Press Inc., 2019. Published • 10.1007/978-1-4939-9420-5_7 Solá, S.; Ribeiro, M.F.; Genebra, T.; Rodrigues, C.M.P.. "Modulation of cell fate by tauroursodeoxycholic acid: All paths lead to mitochondria". In Mitochondrial Biology and Experimental Therapeutics, 407-421. Springer, 2018. Published Pereira, D.M.; Rodrigues, C.M.P.. "miRNAs as modulators of EGFR therapy in colorectal cancer". In Targeted Therapy of Colorectal Cancer Subtypes. Advances in Experimental Medicine and Biology, 133-147. Springer, 2018. Published • 10.1007/978-3-030-02771-1_9 Machado, M.V.; Ferreira, D.M.S.; Castro, R.E.; Silvestre, A.R.; Evangelista, T.; Coutinho, J.; Carepa, F.; et al. "Liver and muscle in morbid obesity: The interplay of fatty liver and insulin resistance". In Obesity Epidemiology, Pathogenesis, and Treatment: A Multidisciplinary Approach, 145-173. Apple Academic Press, 2016. Published • 10.1371/journal.pone.0031738 Borralho, P.M.; Rodrigues, C.M.P.; Steer, C.J.. "microRNAs in mitochondria: An unexplored niche". In Advances in Experimental Medicine and Biology, 31-51. Springer, 2015. Published • 10.1007/978-3-319-22380-3_3 Borralho, P.M.; Steer, C.J.; Rodrigues, C.M.P.. "Isolation of mitochondria from liver and extraction of total RNA and protein: Analyses of microRNA and protein expressions". In Mitochondrial Regulation: Methods and Protocols, 9-12. Springer, 2015. 10.1007/978-1-4939-1875-1_2 Ramalho, R.M.; Viana, R.J.S.; Nunes, A.F.; Low, W.C.; Steer, C.J.; Rodrigues, C.M.P.. "Control of apoptosis in experimental alzheimer’s disease: Therapeutic opportunities for an ancient bile acid". In Neurochemistry: Molecular Aspects, Cellular Aspects and Clinical Applications, 103-131. Nova Science Publishers, 2010. Published Amaral, J.D.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Nuclear steroid receptors in apoptosis". In Modern Insights Into Disease From Molecules to Man: Apoptosis, 113-129. Science Publishers, 2010. Published Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Bile Acids as Modulators of Apoptosis". In Hepatotoxicity: From Genomics to in-vitro and in-vivo, 391-419. Jonh Wiley & Sons, 2008. Published Rodrigues, C.M.P.; Castro, R.E.; Steer, C.J.. "The Role of Bile Acids in the Modulation of Apoptosis". In Principles of Medical Biology. The Liver in Biology and Disease, 119-146. Elsevier Science, 2004. Published • 10.1016/S1569-2582(04)15005-8
Conference paper	Condelipes, P.G.M.; Fontes, P.M.; Nikolaidou, K.; Marques, V.; Bras, E.J.S.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Development of a Microfluidic Colorectal Cancer Cell Culture System with Integrated Optical Sensors for Rapid Phage Selection". 2020. 10.1109/SENSORS47125.2020.9278738 Brás, E.J.S.; Condelipes, P.G.M.; Fontes, P.M.; Serrão, R.F.; Marques, V.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Development of a microfluidic platform for targeted phage selection: In pursuit of personalized colorectal cancer treatments". 2019.
Journal article	Rodrigues, CMP. "Total of ca. 300 indexed peer-reviewed publications (300 papers; 20 book chapters; 1 book; 6 patents; Google Scholar: h-index 85; ca. 44000 citations; Scopus: h-index 70; ca. 24000 citations)". (2024): Duarte-Silva, Sara; Da Silva, Jorge Diogo; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3". Journal of Clinical Investigation 134 5 (2024): http://dx.doi.org/10.1172/jci162246. 10.1172/jci162246 Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Costa, Daniela; Moutinho, Miguel; Mateus, Joana; Mendes de Almeida, Rita; et al. "Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 3 (2024): 166993. http://dx.doi.org/10.1016/j.bbadis.2023.166993. 10.1016/j.bbadis.2023.166993 Nunes, M.J.; Carvalho, A.N.; Sá-Lemos, C.; Colaço, M.; Cervenka, I.; Ciraci, V.; Santos, S.G.; et al. "Sustained PGC-1a2 or PGC-1a3 expression induces astrocyte dysfunction and degeneration". European Journal of Cell Biology 103 1 (2024): 151377. http://dx.doi.org/10.1016/j.ejcb.2023.151377. 10.1016/j.ejcb.2023.151377 Caria, Inês; Nunes, Maria João; Ciraci, Viviana; Carvalho, Andreia Neves; Ranito, Catarina; Santos, Susana G.; Gama, Maria João; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 2 (2024): 166980. http://dx.doi.org/10.1016/j.bbadis.2023.166980. 10.1016/j.bbadis.2023.166980 Despoina Varamogianni-Mamatsi; Maria João Nunes; Vanda Marques; Thekla I. Anastasiou; Eirini Kagiampaki; Emmanouela Vernadou; Thanos Dailianis; et al. "Comparative Chemical Profiling and Antimicrobial/Anticancer Evaluation of Extracts from Farmed versus Wild Agelas oroides and Sarcotragus foetidus Sponges". Marine Drugs (2023): https://doi.org/10.3390/md21120612. 10.3390/md21120612 André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, Joana D.; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136. 10.3389/fvets.2023.1236136 Vanda Marques; Fabiola Arella; Marta B. Afonso; André A. Santos; Cecília M.P. Rodrigues. "Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer". Clinical Science (2023): https://doi.org/10.1042/CS20230411. 10.1042/CS20230411 Rodrigues PM; Afonso MB; Simão AL; Islam T; Gaspar MM; O'Rourke CJ; Lewinska M; et al. "miR-21-5p promotes NASH-related hepatocarcinogenesis.". Liver international : official journal of the International Association for the Study of the Liver (2023): http://europepmc.org/abstract/med/37534739. 10.1111/liv.15682 Mózes, Ferenc E; Lee, Jenny A; Vali, Yasaman; Alzoubi, Osama; Staufer, Katharina; Trauner, Michael; Paternostro, Rafael; et al. "Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis". The Lancet Gastroenterology & Hepatology 8 8 (2023): 704-713. http://dx.doi.org/10.1016/s2468-1253(23)00141-3. 10.1016/s2468-1253(23)00141-3 Matos, Ana I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acúrcio, Rita C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://dx.doi.org/10.1002/advs.202300299. 10.1002/advs.202300299 Einer, Claudia; Munk, Ditte Emilie; Park, Eok; Akdogan, Banu; Nagel, Judith; Lichtmannegger, Josef; Eberhagen, Carola; et al. "ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease Rats". Gastroenterology 165 1 (2023): 187-200.e7. http://dx.doi.org/10.1053/j.gastro.2023.03.216. 10.1053/j.gastro.2023.03.216 Pinho, Jacinta O.; Matias, Mariana; Godinho-Santos, Ana; Amaral, Joana D.; Mendes, Eduarda; Perry, Maria Jesus; Francisco, Ana Paula; Rodrigues, Cecília M.P.; Gaspar, M. Manuela. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics 640 (2023): 123011. http://dx.doi.org/10.1016/j.ijpharm.2023.123011. 10.1016/j.ijpharm.2023.123011 Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; et al. "Apoptotic cell death in disease—Current understanding of the NCCD 2023". Cell Death & Differentiation 30 5 (2023): 1097-1154. http://dx.doi.org/10.1038/s41418-023-01153-w. 10.1038/s41418-023-01153-w Fernando Capela e Silva; Cecília M. P. Rodrigues. "Apoptosis—50 Years after Its Discovery". Biomedicines (2023): https://doi.org/10.3390/biomedicines11041196. 10.3390/biomedicines11041196 Cristiana Domingues; Pedro Mendes Fontes; Pedro G. M. Condelipes; Vanda Marques; Marta B. Afonso; Virginia Chu; Cecília M. P. Rodrigues; João Pedro Conde. "Microfluidic Detection of Adenylate Kinase as a Cell Damage Biomarker". Chemosensors (2023): https://doi.org/10.3390/chemosensors11040220. 10.3390/chemosensors11040220 Joana Lopes; Tânia Ferreira-Gonçalves; Lia Ascensão; Ana S. Viana; Lina Carvalho; José Catarino; Pedro Faísca; et al. "Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041120. 10.3390/pharmaceutics15041120 Marta Clariano; Vanda Marques; João Vaz; Salma Awam; Marta B. Afonso; Maria Jesus Perry; Cecília MP Rodrigues. "Monocarbonyl Analogs of Curcumin with Potential to Treat Colorectal Cancer". Chemistry & Biodiversity (2023): https://doi.org/10.1002/cbdv.202300222. 10.1002/cbdv.202300222 Lee, Jenny; Westphal, Max; Vali, Yasaman; Boursier, Jerome; Petta, Salvatorre; Ostroff, Rachel; Alexander, Leigh; et al. "Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study". Hepatology 78 1 (2023): 258-271. http://dx.doi.org/10.1097/hep.0000000000000364. 10.1097/hep.0000000000000364 Afonso, Marta B.; Marques, Vanda; van Mil, Saskia W. C.; Rodrigues, Cecilia M. P.. "Human liver organoids: From generation to applications". Hepatology Publish Ah (2023): http://dx.doi.org/10.1097/hep.0000000000000343. 10.1097/hep.0000000000000343 Gnocchi, Davide; Afonso, Marta B.; Cavalluzzi, Maria Maddalena; Lentini, Giovanni; Ingravallo, Giuseppe; Sabbà, Carlo; Rodrigues, Cecilia M. P.; Mazzocca, Antonio. "Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline-deficient l-amino acid-defined diet prevents hepatocarcinogenesis in mice". Molecular Carcinogenesis 62 5 (2023): 577-582. http://dx.doi.org/10.1002/mc.23516. 10.1002/mc.23516 Santos A; Delgado TC; Marques V; Moncayo CR; Alonso C; Vidal-Puig A; Hall Z; Martínez-Chantar ML; Rodrigues CMP. "Spatial metabolomics and its application in the liver.". Hepatology (Baltimore, Md.) (2023): http://europepmc.org/abstract/med/36811413. 10.1097/hep.0000000000000341 Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy 157 (2023): 114021. http://dx.doi.org/10.1016/j.biopha.2022.114021. 10.1016/j.biopha.2022.114021 Gnocchi, D.; Afonso, M.B.; Cavalluzzi, M.M.; Lentini, G.; Ingravallo, G.; Sabbà, C.; Rodrigues, C.M.P.; Mazzocca, A.. "Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline-deficient l-amino acid-defined diet prevents hepatocarcinogenesis in mice". Molecular Carcinogenesis (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85147505019&partnerID=MN8TOARS. 10.1002/mc.23516 Pinho, J.O.; Matias, M.; Marques, V.; Eleutério, C.; Fernandes, C.; Gano, L.; Amaral, J.D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine and Pharmacotherapy 157 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141996153&partnerID=MN8TOARS. 10.1016/j.biopha.2022.114021 Rodrigues, Cecília M. P.. "Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines". Journal of Physiology and Biochemistry 79 2 (2023): 261-272. doi: 10.1007/s13105-022-00936-y. Published Vanda Marques; Susana Ourô; Marta B. Afonso; Cecília M. P. Rodrigues. "Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines". Journal of Physiology and Biochemistry (2022): https://doi.org/10.1007/s13105-022-00936-y. 10.1007/s13105-022-00936-y Afonso, Marta B.; Islam, Tawhidul; Magusto, Julie; Amorim, Ricardo; Lenoir, Véronique; Simões, Rui F.; Teixeira, José; et al. "RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease". Hepatology 77 4 (2022): 1319-1334. http://dx.doi.org/10.1002/hep.32756. 10.1002/hep.32756 Joana Lopes; Cecília M. P. Rodrigues; Maria Manuela Gaspar; Catarina Pinto Reis. "Melanoma Management: From Epidemiology to Treatment and Latest Advances". Cancers (2022): https://doi.org/10.3390/cancers14194652. 10.3390/cancers14194652 Joana Lopes; Cecília M. P. Rodrigues; Maria Manuela Gaspar; Catarina Pinto Reis. "How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091817. 10.3390/pharmaceutics14091817 Natália Aniceto; Vanda Marques; Joana D. Amaral; Patrícia A. Serra; Rui Moreira; Cecília M. P. Rodrigues; Rita C. Guedes. "Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors". Molecules (2022): https://doi.org/10.3390/molecules27154718. 10.3390/molecules27154718 Tawhidul Islam; Marta B. Afonso; Cecília M. P. Rodrigues. "The role of RIPK3 in liver mitochondria bioenergetics and function". European Journal of Clinical Investigation 52 3 (2022): https://doi.org/10.1111/eci.13648. 10.1111/eci.13648 Tânia Ferreira-Gonçalves; Maria Manuela Gaspar; João M. P. Coelho; Vanda Marques; Ana S. Viana; Lia Ascensão; Lina Carvalho; et al. "The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/1/71. 10.3390/biom12010071 Alves, C.; Silva, J.; Afonso, M.B.; Guedes, R.A.; Guedes, R.C.; Alvariño, R.; Pinteus, S.; et al. "Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models". Biomedicine and Pharmacotherapy 149 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85127165182&partnerID=MN8TOARS. 10.1016/j.biopha.2022.112886 Magusto, J.; Beaupère, C.; Afonso, M.B.; Auclair, M.; Delaunay, J.-L.; Soret, P.-A.; Courtois, G.; et al. "The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes". iScience 25 10 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139065321&partnerID=MN8TOARS. 10.1016/j.isci.2022.105166 Espadinha, M.; Lopes, E.A.; Marques, V.; Amaral, J.D.; dos Santos, D.J.V.A.; Mori, M.; Daniele, S.; et al. "Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors". European Journal of Medicinal Chemistry 241 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85135699740&partnerID=MN8TOARS. 10.1016/j.ejmech.2022.114637 Afonso, M.B.; Islam, T.; Magusto, J.; Amorim, R.; Lenoir, V.; F. Simões, R.; Teixeira, J.; et al. "RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease". Hepatology (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139673348&partnerID=MN8TOARS. 10.1002/hep.32756 Condelipes, P.G.M.; Fontes, P.M.; Godinho-Santos, A.; Brás, E.J.S.; Marques, V.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Towards personalized antibody cancer therapy: development of a microfluidic cell culture device for antibody selection". Lab on a Chip 22 23 (2022): 4717-4728. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142444651&partnerID=MN8TOARS. 10.1039/d2lc00918h Diana Alves; Sidónio Duarte; Pedro Arsénio; Joana Gonçalves; Rodrigues CMP; Ana Lourenço; Patrícia Máximo. "Exploring the Phytochemicals of Acacia melanoxylon R. Br.". Plants (2021): https://www.mdpi.com/2223-7747/10/12/2698. 10.3390/plants10122698 Sara Oliveira; Pedro A. Dionísio; Gaspar MM; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/10/5289. 10.3390/ijms22105289 Jacinta O. Pinho; Inês V. da Silva; Joana D. Amaral; Cecília M.P. Rodrigues; Angela Casini; Graça Soveral; M. Manuela Gaspar. "Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management". International Journal of Pharmaceutics 599 (2021): 120463-120463. https://doi.org/10.1016/j.ijpharm.2021.120463. 10.1016/j.ijpharm.2021.120463 Joana Lopes; Tânia Ferreira-Gonçalves; Isabel V. Figueiredo; Rodrigues CMP; Hugo Ferreira; David Alves Ferreira; Ana S. Viana; et al. "Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma". Biomolecules (2021): https://www.mdpi.com/2218-273X/11/4/511. 10.3390/biom11040511 Rosa Couto; Constantino Coelho; Bassim Mounssef; Sara F. de A. Morais; Camila D. Lima; Wallans Torres Pio dos Santos; Félix Carvalho; et al. "3,4-Methylenedioxypyrovalerone (MDPV) Sensing Based on Electropolymerized Molecularly Imprinted Polymers on Silver Nanoparticles and Carboxylated Multi-Walled Carbon Nanotubes". Nanomaterials (2021): https://www.mdpi.com/2079-4991/11/2/353. 10.3390/nano11020353 Dionísio, PA; Amaral, JD; Rodrigues, CMP. "Oxidative stress and regulated cell death in Parkinson’s disease". Ageing Research Reviews (2021): 101263. http://dx.doi.org/10.1016/j.arr.2021.101263. Open access • Published • 10.1016/j.arr.2021.101263 Marin, J.J.G.; Prete, M.G.; Lamarca, A.; Tavolari, S.; Landa-Magdalena, A.; Brandi, G.; Segatto, O.; et al. "Correction: Current and novel therapeutic opportunities for systemic therapy in biliary cancer (British Journal of Cancer, (2020), 123, 7, (1047-1059), 10.1038/s41416-020-0987-3)". British Journal of Cancer 125 6 (2021): 904-904. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110149465&partnerID=MN8TOARS. 10.1038/s41416-020-01243-3 Fernández-Tussy, P.; Rodríguez-Agudo, R.; Fernández-Ramos, D.; Barbier-Torres, L.; Zubiete-Franco, I.; Davalillo, S.L.; Herraez, E.; et al. "Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity". Cell Death and Disease 12 6 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107003939&partnerID=MN8TOARS. 10.1038/s41419-021-03827-0 Mózes, F.E.; Lee, J.A.; Selvaraj, E.A.; Jayaswal, A.N.A.; Trauner, M.; Boursier, J.; Fournier, C.; et al. "Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: An individual patient data meta-analysis". Gut (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106947127&partnerID=MN8TOARS. 10.1136/gutjnl-2021-324243 Selvaraj, E.A.; Mózes, F.E.; Jayaswal, A.N.A.; Zafarmand, M.H.; Vali, Y.; Lee, J.A.; Levick, C.K.; et al. "Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis". Journal of Hepatology 75 4 (2021): 770-785. http://www.scopus.com/inward/record.url?eid=2-s2.0-85108940286&partnerID=MN8TOARS. 10.1016/j.jhep.2021.04.044 Oliveira, S.R.; Dionísio, P.A.; Gaspar, M.M.; Correia Guedes, L.; Coelho, M.; Rosa, M.M.; Ferreira, J.J.; Amaral, J.D.; Rodrigues, C.M.P.. "miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108989747&partnerID=MN8TOARS. 10.3389/fcell.2021.661461 Marques, V.; Afonso, M.B.; Bierig, N.; Duarte-Ramos, F.; Santos-Laso, Á.; Jimenez-Agüero, R.; Eizaguirre, E.; et al. "Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD". Frontiers in Medicine 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85109172986&partnerID=MN8TOARS. 10.3389/fmed.2021.683250 Mendes, M.O.; Rosa, A.I.; Carvalho, A.N.; Nunes, M.J.; Dionísio, P.; Rodrigues, E.; Costa, D.; et al. "Corrigendum to “Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy” [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1–9.] (Molecular and Cellular Neuroscience (2019) 96 (1–9), (S1044743118303907), (10.1016/j.mcn.2019.01.003))". Molecular and Cellular Neuroscience 114 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105752069&partnerID=MN8TOARS. 10.1016/j.mcn.2021.103626 Afonso, Marta B; Rodrigues, Pedro M; Mateus-Pinheiro, Miguel; Simão, André L; Gaspar, Maria M; Majdi, Amine; Arretxe, Enara; et al. "RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease". Gut (2020): gutjnl-2020. http://dx.doi.org/10.1136/gutjnl-2020-321767. Open access • Published • 10.1136/gutjnl-2020-321767 Santos, André A.; Afonso, Marta B.; Ramiro, Ricardo S.; Pires, David; Pimentel, Madalena; Castro, Rui E.; Rodrigues, Cecília M.P.. "Host miRNA-21 promotes liver dysfunction by targeting small intestinal Lactobacillus in mice". Gut Microbes 12 1 (2020): 1840766. http://dx.doi.org/10.1080/19490976.2020.1840766. Published • 10.1080/19490976.2020.1840766 Ourô, Susana; Mourato, Cláudia; Velho, Sónia; Cardador, André; Ferreira, Marisa P.; Albergaria, Diogo; Castro, Rui E.; Maio, Rui; Rodrigues, Cecília M. P.. "Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.577653. Published • 10.3389/fonc.2020.577653 Susana Ourô; Cláudia Mourato; Marisa P. Ferreira; Diogo Albergaria; André Cardador; Rui E Castro; Rui Maio; Rodrigues CMP. "Evaluation of Tissue and Circulating miR-21 as Potential Biomarker of Response to Chemoradiotherapy in Rectal Cancer". Pharmaceuticals (2020): https://www.mdpi.com/1424-8247/13/9/246. 10.3390/ph13090246 Sara Oliveira; Pedro A. Dionísio; Leonor Correia Guedes; Nilza Gonçalves; Miguel Coelho; Mário M. Rosa; Joana D. Amaral; Joaquim J. Ferreira; Rodrigues CMP. "Circulating Inflammatory miRNAs Associated with Parkinson’s Disease Pathophysiology". Biomolecules (2020): https://www.mdpi.com/2218-273X/10/6/945. 10.3390/biom10060945 Tudor Mocan; André Simão; Rui E Castro; Rodrigues CMP; Artur Slomka; Bingduo Wang; Christian Strassburg; et al. "Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning?". Journal of Clinical Medicine (2020): https://www.mdpi.com/2077-0383/9/5/1541. 10.3390/jcm9051541 Cotas, João; Marques, Vanda; Afonso, Marta B.; Rodrigues, Cecília M. P.; Pereira, Leonel. "Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres". Marine Drugs 18 1 (2020): 50. http://dx.doi.org/10.3390/md18010050. 10.3390/md18010050 Balasubramanian, L.; Zuzarte-Luís, V.; Syed, T.; Mullick, D.; Deb, S.; Ranga-Prasad, H.; Meissner, J.; et al. "Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development". Frontiers in Cellular and Infection Microbiology 9 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078863463&partnerID=MN8TOARS. 10.3389/fcimb.2019.00451 Majdi, A.; Aoudjehane, L.; Ratziu, V.; Islam, T.; Afonso, M.B.; Conti, F.; Mestiri, T.; et al. "Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease". Journal of Hepatology (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078466129&partnerID=MN8TOARS. 10.1016/j.jhep.2019.11.008 Dionísio, P.A.; Amaral, J.D.; Rodrigues, C.M.P.. "Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases". (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079271604&partnerID=MN8TOARS. 10.1016/bs.ircmb.2019.12.006 Gautheron, Jérémie; Gores, Gregory J.; Rodrigues, Cecília M.P.. "Lytic cell death in metabolic liver disease". Journal of Hepatology 73 2 (2020): 394-408. http://dx.doi.org/10.1016/j.jhep.2020.04.001. Published • 10.1016/j.jhep.2020.04.001 Brito, H.; Marques, V.; Afonso, M.B.; Brown, D.G.; Börjesson, U.; Selmi, N.; Smith, D.M.; et al. "Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition". Cell Death Discovery 6 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079729058&partnerID=MN8TOARS. Published • 10.1038/s41420-020-0240-0 Pereira, D.M.; Rodrigues, C.M.P.. "Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway". Trends in Molecular Medicine 26 (2020): 394-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079379227&partnerID=MN8TOARS. Published • 10.1016/j.molmed.2020.01.006 Couto, Rosa A.S.; Mounssef, Bassim; Carvalho, Félix; Rodrigues, Cecília M.P.; Braga, Ataualpa A.C.; Aldous, Leigh; Gonçalves, Luís Moreira; Quinaz, M. Beatriz. "Methylone screening with electropolymerized molecularly imprinted polymer on screen-printed electrodes". Sensors and Actuators B: Chemical (2020): 128133. http://dx.doi.org/10.1016/j.snb.2020.128133. 10.1016/j.snb.2020.128133 Rodrigues, CMP; Fernandes, MB; Costa, M; Ribeiro, MF; Siquenique, S; Santos, SS; Martins, J; et al. "Reprograming of lipid metabolism as a new driving force behind tauroursodeoxycholic acid-induced neural stem cell proliferation". Frontiers Cell and Developmental Biology 8 335 (2020): Rodrigues, CMP; Mocan, T; Simão, AL; Castro, RE; Wang, B.; Wohler, A; Willms, A; Kornek, M. "Liquid biopsies in hepatocellular carcinoma: are we winning?". Journal of Clinical Medicine (2020): In press Rodrigues, CMP; Marín, J.J.G.; Prete, MG; Tavolari, S; Lamarca, A; Landa Magdalena, A; Bridgewater, J; et al. "Current and novel therapeutic opportunities in biliary cancer". British Journal of Cancer (2020): In press Ribeiro, Maria F; Santos, André A; Afonso, Marta B; Rodrigues, Pedro M; Sá Santos, Sónia; Castro, Rui E; Rodrigues, Cecília M P; Solá, Susana. "Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation". Brain Communications 2 2 (2020): http://dx.doi.org/10.1093/braincomms/fcaa165. Open access • Published • 10.1093/braincomms/fcaa165 Marin, J.J.G.; Prete, M.G.; Lamarca, A.; Tavolari, S.; Landa-Magdalena, A.; Brandi, G.; Segatto, O.; et al. "Current and novel therapeutic opportunities for systemic therapy in biliary cancer". British Journal of Cancer 123 7 (2020): 1047-1059. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088295268&partnerID=MN8TOARS. 10.1038/s41416-020-0987-3 Fernandes, M.B.; Costa, M.; Ribeiro, M.F.; Siquenique, S.; Sá Santos, S.; Martins, J.; Coelho, A.V.; et al. "Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation". 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"A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation". Journal of Clinical Investigation 101 12 (1998): 2790-2799. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032525819&partnerID=MN8TOARS. 10.1172/JCI1325 Brites, D.; Rodrigues, C.M.P.; Cardoso, M.D.C.; Graça, L.M.. "Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration". European Journal of Obstetrics Gynecology and Reproductive Biology 76 2 (1998): 165-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032007521&partnerID=MN8TOARS. 10.1016/S0301-2115(97)00185-1 Brites, D.; Rodrigues, C.M.P.; Van-Zeller, H.; Alexandra Brito; Silva, R.. "Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal". 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"Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei". Gastroenterology 112 1 (1997): 226-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031024075&partnerID=MN8TOARS. 10.1016/S0016-5085(97)70239-7 Setchell, K.D.R.; Rodrigues, C.M.P.; Podda, M.; Crosignani, A.. "Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis". Gut 38 3 (1996): 439-446. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029863605&partnerID=MN8TOARS. 10.1136/gut.38.3.439 Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.; Setchell, K.D.R.. "Formation of ¿22-bile acids in rats is not gender specific and occurs in the peroxisome". Journal of Lipid Research 37 3 (1996): 540-550. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029666426&partnerID=MN8TOARS. Crosignani, A.; Setchell, K.D.R.; Invernizzi, P.; Larghi, A.; Rodrigues, C.M.P.; Podda, M.. "Clinical pharmacokinetics of therapeutic bile acids". Clinical Pharmacokinetics 30 5 (1996): 333-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029922694&partnerID=MN8TOARS. 10.2165/00003088-199630050-00002 Rodrigues, C.M.P.; Setchell, K.D.R.. "Performance characteristics of reversed-phase bonded silica cartridges for serum bile acid extraction". Biomedical Chromatography 10 1 (1996): 1-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030028096&partnerID=MN8TOARS. 10.1002/(SICI)1099-0801(199601)10:1<1::AID-BMC536>3.0.CO;2-3 Kren, B.T.; Rodrigues, C.M.P.; Setchell, K.D.R.; Steer, C.J.. "Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding". American Journal of Physiology - Gastrointestinal and Liver Physiology 269 6 32-6 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029558347&partnerID=MN8TOARS. Setchell, K.D.R.; Rodrigues, C.M.P.; O'Connell, N.C.; Yamashita, H.; Kren, B.T.; Steer, C.J.. "¿²²-Ursodeoxycholic Acid, a Unique Metabolite of Administered Ursodeoxycholic Acid in Rats, Indicating Partial ß-Oxidation as a Major Pathway for Bile Acid Metabolism". Biochemistry 34 13 (1995): 4169-4178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028986129&partnerID=MN8TOARS. 10.1021/bi00013a004 Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.; Setchell, K.D.R.. "The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation". Gastroenterology 109 6 (1995): 1835-1844. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028842929&partnerID=MN8TOARS. 10.1016/0016-5085(95)90750-5 Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.; Setchell, K.D.R.. "Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate". Gastroenterology 109 2 (1995): 564-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029098462&partnerID=MN8TOARS. 10.1016/0016-5085(95)90346-1 Brites, D.; Poeiras, J.; Rodrigues, C.. "Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy \| Colestase intra-hepática da gravidez. Etiopatogénese, prognóstico e terapêutica.". Acta medica portuguesa 7 3 (1994): 181-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028391098&partnerID=MN8TOARS.

Intellectual property

Patent

Finch, M.D.; Low, W.C.; Steer, C.J.; Munshi, C.B.; Rodrigues, C.M.P. (DC18-39A7-F287); Lucas de Oliveira, S.D.. 2018. "Finch MD, Low W, Steer C, Munshi CB, Rodrigues CMP, Lucas de Oliveira SD, Deuterated Bile Acids. Publication number: Pub. Date: Feb. 1, 2018. Pub. No. US20180030084A1. Family: US(3) WO (1). 2014: US14520889; 2016 US15052221; 2017 US15651721; 2018 US20180030084A1.".
Finch, M.D.; Munshi, C.B.; Rodrigues, C.M.P. (DC18-39A7-F287); de Oliveira, S.D.L.. 2018. "Finch M, Munshi CB, Rodrigues CMP, de Oliveira SDL. Fluorinated and Alkylated Bile Acids. US Patent App. 15/556,768, 2018 US20180044373A1".
Rodrigues, Cecília. 2013. "Tauroursodeoxycholic Acid Attenuates or Abolishes Formation and Deposition of Amyloid-ß Peptide. Provisional. Pub. Date: September 23, 2013. Publication number: WO2013142490A2.".
Rodrigues, Cecília. 2008. "Methods for Treating Visual Disorders. Pub. Date: August 14, 2008. Pub. No. US20080194531 A1. Also published as EP1871385A1, WO2006086452A1.".
Rodrigues, Cecília. 2006. "Methods of Treating Injuries of the Nervous System Associated with Hemorrhage. Pub. Date: June 22, 2006. Pub. No. Serial No. US20060135494 A1. Also published as DE60330501D1, EP1575578A2, EP1575578A4, EP1575578B1, WO2004043342A2, WO2004043342A3.".
Steer, C.J.; Kren, B.T.; Fan, G.; Rodrigues, C.M (DC18-39A7-F287). 2003. "Methods of Limiting Apoptosis of Cells. Pub. Date: April 8, 2003. Publication No. US6544972 B1. Also published as WO1999015179A1, WO1999015179A8, WO1999015179A9, US2003044413A1.".
Granted/Issued

Other

Other output

Microfluidic Detection of Adenylate Kinase as Cell Damage Biomarker and Integration with a Cell Chip. 2022. Domingues, C.; Fontes, P.M.; Condelipes, P.G.M.; Marques, V.; Afonso, M.B.; Chu, V.; Rodrigues, C.M.P.; Conde, J.P.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144138915&partnerID=MN8TOARS.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2020/01/01	Total of ca. 250 oral communications (> 100 international)
2020	Circulating miR-335 is reduced in Parkinson’s disease patients and its overexpression negatively regulates inflammatory events	AD/PD Meeting 2020 AD/PD (Viena, Germany)
2019	Diet-associated gut microbiota metabolites dictate mitochondrial stress as a key regulator of adult neurogenesis.	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019	Discovery of colon cancer stem cell inhibitors by high-throughput screening in a 3D spheroid model.	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019	Tuning cell death in neuroinflammation.	53rd Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Coimbra, Portugal)
2019	RIP3 deficiency remodels mitochondrial bioenergetics and function in experimental NAFLD	53rd Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Coimbra, Portugal)
2019	High-throughput phenotypic screening of colon cancer stem cell inhibitors using tumourspheres.	27th United European Gastroenterology Week United European Gastroenterology (Barcelona, Spain)
2019	miRNA-21 signals through a gut-liver axis to regulate experimental cholestasis.	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Vienna, Germany)
2019	Genetic deletion of RIP3 abrogates dopaminergic neuronal death in the MPTP-mouse model of Parkinson’s disease	AD/PD 2019, 14th International Conference on Alzheimer's and Parkinson's DiseasesAD/PD 2019 AD/PD 2019 (Lisboa, Portugal)
2019	Nanoformulated hybrid molecules with high in vitro and in vivo potential against melanoma	EUFEPS Annual Meeting 2019 EUFEPS (Frankfurt, Germany)
2019	FXR mode of action dans le maladie chroniques du foie	85e Journées Scientifiques de l’APEF. 20e Journée de Formation Médicale Continue en Hétatologie APEF (Marselha, France)
2019	Metabolic liver disease	ICAN Series 2019. Cardiometabolic disease interfaces: defining new paradigms ICAN (Paris, France)
2019	Genetics and epigenetics of NAFLD progression	Symposium Molecular basis of non-alcoholic fatty liver disease progression V UIMP-IBIS School of Biomedicine (Sevilha, Spain)
2018	Muscle miR-34a is activated during NAFLD progression, promoting insulin resistance and mitochondrial dynamics dysfunction	26th United European Gastroenterology Week United European Gastroenterology (Viena, Germany)
2018	Deregulation of small intestine permeability by miRNA-21 in liver disease.	9th biennial meeting for the Society for Free Radical Research International Society for Free Radical Research International (Lisboa, Portugal)
2017	miRNAs as biomarkers and targets.	European Association for the Study of the Liver, NAFLD Summit European Association for the Study of the Liver (Roma, Italy)
2017	miRNAs as biomarkers and regulators of liver disease.	51st Conference of the European Society for Clinical Investigation European Society for Clinical Investigation (Genova)
2017	Molecular markers in colorectal cancer: miRNAs and its clinical implications.	Leaping Forward Oncology – International Clinical Congress (Lisboa, Portugal)
2017	miR-21 ablation and obeticholic acid ameliorate NASH in mice	Keystone Symposium Bile Acid Receptors as Signal Integrators in Liver and Metabolism Keystone Symposia (Monterey, United States)
2016	Selective targeting of FXRa isoforms by novel bile acid derivatives is associated with inhibition of lipotoxicity in liver cells	24th United European Gastroenterology Week United European Gastroenterology (Viena, Germany)
2016	Activation of necroptosis in human and experimental cholestasis	24th United European Gastroenterology Week United European Gastroenterology (Viena, Germany)
2016	The role of miRNA-145 in colon cancer stem cell-like cells.	24th United European Gastroenterology Week United European Gastroenterology (Viena, Germany)
2016	Improving metabolic parameters in NAFLD by targeting nuclear receptors	24th United European Gastroenterology Week United European Gastroenterology (Viena, Germany)
2016	RIP3 regulates acute cholestasis-associated necroptotic signaling and cell death.	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Barcelona, Spain)
2015	Alcoholic and non-alcoholic steatohepatitis: Mechanisms of cell death and clinical relevance	XX Annual Conference “Hepatology Today 2015” EASL/RSLS Symposium RSLS/EASL (Moscovo, Russia)
2015	Dual targeting of microRNA-21 and FXR ameliorates NAFLD pathogenesis in mice.	23rd United European Gastroenterology Week United European Gastroenterology (Barcelona, Spain)
2015	MEK5/ERK5 signalling controls colon cancer cell sensitivity to 5-fluorouracil through a p53 dependent mechanism	23rd United European Gastroenterology Week United European Gastroenterology (Barcelona, Spain)
2015	Contribution of miRNA-143 and miRNA-145 to cetuximab-mediated cellular cytotoxicity in colon cancer cells	23rd United European Gastroenterology Week United European Gastroenterology (Barcelona, Spain)
2015	The dual role of necroptosis in cholestasis	23th Euroconference on Apoptosis “Death Pathways and Beyond” European Cell Death Organization (Genebra, Switzerland)
2014	MEK5/ERK5 signalling activates NF-¿B and promotes a more aggressive phenotype in human colon cancer cells	22nd United European Gastroenterology Week United European Gastroenterology (Viena, Germany)
2014	Deoxycholic acid trigers primary rat hepatocyte apoptosis in a dose-dependent manner by hampering caspase-2/NF-¿¿-associated activation of miRNA-21	64th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Washington, United States)
2014	Moving Forward: Discussions on implications for patients from basic research, Joint Workshop EASL-I-PSC-G	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Londres, United Kingdom)
2013	Bile acids: hepatotoxicity and hepatoprotection.	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Londres, United Kingdom)
2013	miR-143 and miR-145 overexpression improve the response to cetuximab in HCT116 KRAS mutant colon cancer cells	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Germany)
2013	MEK5/ERK5 signalling modulates cell proliferation and survival and influences sensitivity to 5-fluorouracil in colon cancer cells	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Germany)
2013	MEK5/ERK5 expression is increased in colon cancer adenomas and adenocarcinomas, and MEK5/ERK5 signalling accelerates cell cycle progression and migration in SW620 colon cancer cells	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Germany)
2013	Skeletal muscle miRNAs and correlation with liver miRNAs in non-alcoholic fatty liver disease, and targeting by tauroursodeoxycholic acid in vitro	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Germany)
2013	JNK1-dependent modulation of miR-34a contributes to apoptosis induced by deoxycholic acid in primary rat hepatocytes	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Amsterdão)
2012	miR-34a/SIRT1/p53 signaling is activated in human non-alcoholic fatty liver disease and target by ursodeoxycholic acid in the rat liver via inhibition of p53 transactivation	20th United European Gastroenterology Week United European Gastroenterology (Amsterdão)
2012	Apoptotic miRNA-21/PDCD4 signaling in rat hepatocytes: dose-dependent effect of deoxycholic acid	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Barcelona, Spain)
2011	Increased expression of miR-34 in NAFLD patients and targeting by ursodeoxycholic acid in rat liver	19th United European Gastroenterology Week United European Gastroenterology (Estocolmo, Sweden)
2009	Modulation of the p53-ubiquitin-proteasome degradation pathway by ursodeoxycholic acid	44th Annual Meeting of the European Association for the Study of the Liver European Association for the Study of the Liver (Copenhaga, Denmark)
2007	Antiapoptotic effect of ursodeoxycholic acid in hepatocytes.	Falk Research Workshop Falk Foundation (Goettingen, Germany)
2007	Differential regulation of cyclin D1 and apoptosis by bile acids in primary rat hepatocyte	42st Meeting of the European Association for the Study of Liver Diseases European Association for the Study of the Liver (Barcelona, Spain)
2005	Targeting apoptosis in neurologic disorders.	4th International Congress on Vascular Dementia (Porto, Portugal)
2004	Tauroursodeoxycholic acid, a bile acid with in vivo anti-apoptotic and neuroprotective properties.	XVIII International Bile Acid Meeting Falk Foundation (Estocolmo, Sweden)
2004	Rodrigues CMP. Targeting apoptosis in human diseases.	26th European Society of Parental and Enteric Nutrition European Society of Parental and Enteric Nutrition (Lisboa, Portugal)
2004	Mechanisms of cell death in steatohepatitis – Apoptosis or necrosis?	EASL NASH Monothematic Conference European Association for the Study of the Liver (Lisboa, Portugal)
2004	Enhanced apoptosis and Bcl-2 protein production in the liver of patients with steatohepatitis	39th Meeting of the European Association for the Study of Liver Diseases European Association for the Study of the Liver (Berlim, Germany)
2003	Ursodeoxycholic acid prevents TGF-ß1-induced apoptosis through modulation of the glucocorticoid receptor in primary rat hepatocytes	54th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, United States)
2002	Tauroursodeoxycholic acid for the treatment of acute and chronic neurodegenerative diseases.	XVII International Bile Acid Meeting Falk Foundation (Freiburgo, Germany)
2000	Inhibition of apoptosis in a rat model of Huntington’s disease using tauroursodeoxycholate.	XVI International Bile Acid Meeting Falk Foundation (Haia, Netherlands)
2000	Tauroursodeoxycholate prevents mitochondrial membrane perturbation induced by recombinant Bax protein	51st Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, United States)
2000	Apoptosis induced by deoxycholic acid, unconjugated bilirubin and amyloid ß-peptide reflects mitochondrial perturbation which may be inhibited by ursodeoxycholic acid	35th Annual Meeting of the European Association for the Study of the Liver European Association for the Study of the Liver (Roterdão, Netherlands)
1999	Ursodeoxycholic acid inhibits apoptosis by modulating depolarization and channel-forming activity of the mitochondrial membrane	34th Annual Meeting of the European Association for the Study of the Liver European Association for the Study of the Liver (Nápoles, Italy)
1998	Bile acid pattern in meconium is influenced by cholestasis of pregnancy and not altered after ursodeoxycholic acid therapy	49th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, United States)
1997	A novel role for ursodeoxycholic acid in modulating apoptosis in rat liver, isolated hepatocytes and human hepatoma cells	48th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, United States)
1994	Tauroursodeoxycholic acid (TUDCA) appears more effective than UDCA at displacing hydrophobic bile acids from the bile acid pool of patients with primary biliary cirrhosis	45th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, United States)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020/01/01 - Current	Total of ca. 150 postgraduate student and postdoc supervisions (50 PhD students; 80 MSc students; 13 Postdocs) Supervisor
2020 - 2023	Targeting superficial tumors using a nanotechnological hybrid approach Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 - 2023	Development of new necroptosis inhibitors: targeting RIP1 kinase Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2023	Emerging Biomarkers, Targets and Therapies for Non-alcoholic Fatty Liver Disease Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022	Innovative Therapies and Technologies in Cancer Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	Emerging inflammatory mediators as predictors of oocyte quality and IVF ART (assisted reproduction techniques) treatment outcome: from biochemical markers to clinic Co-supervisor	Ciências Farmacêuticas (PhD) Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2021	Aromatase inhibitors in breast cancer: drug discovery and strategies to overcome acquired resistance Co-supervisor	Ciências Farmacêuticas Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2021	New Drugs to Target Neurodegeneration and Neuroinflammation in Parkinson’s Disease Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	Response to neoadjuvant chemoradiation in rectal cancer. A study on clinical and molecular predictors of response Co-supervisor	Medicina (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2021	Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	miRNA Markers and Cell Death in NAFLD Progression Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Targeting of mitofusin-2 by microRNAs in non-alcoholic fatty liver disease Co-supervisor	Farmácia (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Therapeutic targeting of microRNA-21 and bile acid-activated receptors in non-alcoholic fatty liver disease Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Role of adipose tissue-derived extracellular vesicles on liver cells under steatogenic conditions”, sob orientação de Rui Castro. Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Bioenergetic Regulation of Neural Stem Cell Secretome: a Novel Therapeutic Opportunity for Neurodegeneration Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020	New Drugs to Treat Fatty Liver and Progression to Cancer Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020	Development and application of an innovative disposable sensor for Novel Psychoactive Substances (NPSs) based on electrochemistry Co-supervisor	Ciências Farmacêuticas (PhD) Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2019	Quality and Reporting of Clinical Practice Guidelines on the Management of Parkinson’s Disease Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Probing and Targeting Mitochondria Bioenergetics in Neurodegeneration Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Role of Mitofusin 2 in Non-alcoholic Fatty Liver Disease and Targeting by microRNAs Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Systems Analysis of Inflammation and Neuronal Demise in Neurodegenerative Diseases Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Neuroprotection by histone acetyltransferase modulators: activation or inhibition? Co-supervisor	Ciências Farmacêuticas (PhD) Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2019	Exploring MEK5-ERK5 Signaling in Colorectal Cancer: A Therapeutic Target for Chemosensitization Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Role of the miR-21/MAPK signaling pathway and bile acid-activated receptors in non-alcoholic fatty liver disease progression Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Biological effects of phytocannabinoids and endocannabinoids on ER+ breast cancer cells Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Discovering New Molecules for Non-toxic Differentiation Therapy in Cancer Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Evaluating alterations in adenosine metabolism and function responsible for brown adipose tissue deregulation: Implications in obesity Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	High Throughput Screening of Cell Fate Modulators Using Colon Cancer Stem Cells: Assay Development Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Targeting mitochondria-nucleus communication to improve agEing-impaired neurogenesis Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2018	Programmed Cell Death in Influenza Virus Sub-types Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Necroptosis and mitochondrial dysfunction in NAFLD: potential novel modulators Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	The role of mitochondrial adaptations in the acquistion of the phenotype induced by LDL-cholesterol in breast cancer Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Role of Mi-2/NuRD in chromatin regulation to regulate neural stem cell fate and life-span in Drosophila melanogaster Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2017	Lectins in Mediterranean flora. Evalutation of antitumor activity on HT29 colon cancer cells Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017	Targeting Hepatocyte Necroptosis to Treat Liver Diseases Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017	miR-143, -145 and -21 Modulation in Colon Cancer - from Anticancer Activity to Drug Sensitization Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017	Targeting of miR-21 and Bile Acid Activated Receptors in Non-alcoholic Fatty Liver Disease Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Targeting microglia necroptosis to arrest neuroinflammation Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Screening of necroptosis modulators with potential therapeutic application Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Molecular insights into the role of alpha-synuclein phosphorylation in synucleinophathies Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Spirooxadiazoline oxindoles as potential anticancer agents Co-supervisor	Química Farmacêutica e Terapêutica (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Targeting MicroRNAs for Modulation of the Anti-Tumor Human gd T Cell Differentiation Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016	Efeitos do tratamento com N-acetilcisteina sob o défice cognitivo induzido por estreptozotocina em camundongos Co-supervisor	Universidade Federal de Santa Maria, Brazil
2012 - 2015	Novel Therapeutic Targets in Colon Cancer Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2015	Fine-Tuning Neurogenesis: miRNA Regulatory Networks Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2015	Control of Neuronal Signalling Pathways by CYP46A1, an Enzyme Involved in Brain Cholesterol Homeostasis Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2015	Design and Synthesis of Small Molecule Modulators of p53 Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014	Using TUDCA to Treat AD Pathology in APP/PS1 Mice after Disease Onset Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014	Inhibition of Mutant KRAS Transcription in Human Cancer Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014	A New Regulatory Mechanism Involving p53 in JMJD3-mediated Neurogenesis Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013	Exploring the Role of MEK5/ERK5 Signaling in Colon Cancer and Sensitivity to 5 Fluorouracil Supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013	Avaliação do efeito neuroprotetor do p, p’-dimetoxil disseleneto de difenila em modelos de demência decorrentes da Doença de Alzheimer em roedores: Estudo dos mecanismos envolvidos Co-supervisor	Universidade Federal de Santa Maria, Brazil
2009 - 2013	Apoptosis and miRNAs in Non-Alcoholic Fatty Liver Disease Pathogenesis Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2012	Creatine Protects Against Rotenone-induced Cell Death of Cerebellar Granule Neurons Co-supervisor	Ciências Biofarmacêuticas (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2012	Amyloid ß Peptide and p63: Two Prime Triggers of Neural Apoptosis and Differentiation Supervisor	Neurociências (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2012	Regulation of Neural Stem Cell Proliferation by Apoptosis-relevant Factors Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012	Endogenous Regulatory Circuits Controlled by CYP46A1: Role of 24S-hydroxycholestreol on Small GTPase Activity and its Relation to Neurodegenerative Disorders with Altered Brain Cholesterol Metabolism Co-supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2011	Exploring Antibody-mediated Small RNA Delivery as a Therapeutic Approach in Colon Cancer Supervisor	Bioquímica (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2011	Apoptosis Signaling Associated with Amyloid beta-induced Cellular Dysfunction and Degeneration: Relevance for Alzheimer's disease Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2010	Role of Apoptosis Factors during Mouse Neural Stem Cell Differentiation Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009	Role of Apoptosis and miRNAs in Identifying Novel Therapeutic Targets in Colon Cancer Supervisor	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2008	p53, a Novel Molecular Target of Ursodeoxycholic Acid in Modulating Hepatocyte Apoptosis Supervisor of Joana Amaral	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2007	Potential Role of Apoptosis During Neural Stem Cell Differentiation Supervisor	Università degli Studi di Milano-Bicocca, Italy
2003 - 2007	Signaling Events in Tauroursodeoxycholic Acid Protection of Amyloid beta-peptide-induced Neuronal Death Supervisor of Rita Ramalho	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2002 - 2006	Tauroursodeoxycholic Acid Protection of Stroke: Targeting Cell Survival Cascades Supervisor of Rui Castro	Farmácia (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2001 - 2005	Modulation of Hepatocyte Apoptosis by Ursodeoxycholic Acid: Role of Nuclear Steroid Receptors Supervisor of Susana Solá	Farmácia Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2020/01/01	Total of ca. 220 MSc juries (president in >175); 120 PhD juries (main opponent in >100); 15 Habilitation juries (main opponent in 14)	(Other)
2020	Provas de Agregação em Biologia Experimental e Biomedicina, especialidade em Biologia Molecular, Celular e do Desenvolvimento (Thesis) Main arguer	Paulo Oliveira (Aggregation) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020	Targeting metabolism for resolving Non-Alcoholic Steatohepatitis (Thesis) Main arguer	Jorge Simon Espinosa (PhD) Universidad del País Vasco, Spain
2019	Provas de Agregação em Biociências, especialidade de Bioquímica (Thesis) Main arguer	Rui Carvalho (Aggregation) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019	Identification of a new genetic defect in bile acid synthesis: ACOX2 partial deficiency. Molecular bases, pathophysiology and implication in idiopathic hepatocellular disease (Thesis) Main arguer	Marta Alonso Pena (PhD) Universidad de Salamanca, Spain
2019	Responses to liver damage: macrophage plasticity in tissue recovery and dysbiotic drifts (Thesis) Main arguer	Inês Coelho (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019	Pathophysiology of doxorubicin cardiotoxicity: from mitochondrial homeostasis to biological clocks (Thesis) Main arguer	Luciana Ferreira (PhD) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018	Molecular mechanisms of bile acid-induced apoptosis and cytoprotection (Thesis) Main arguer	Tânia Sousa (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Phenotypes in Inflammatory Bowel Disease (Thesis) Main arguer	Joana Torres (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2018	The Role of Post-Translational Modifications on the Oligomerization, Aggregation and Toxicity of Mutant Huntingtin (Thesis) Main arguer	Joana Santos (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2018	Gold nanoparticles for nanotheranostics in leukemia – Addressing chronic myeloid leukemia (Thesis) Main arguer	Raquel Vinhas (PhD) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017	Provas de Agregação em Farmácia, especialidade de Biologia Celular e Molecular (Thesis) Main arguer	Isabel Carvalho (Aggregation) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	Provas de Agregação em Farmácia, especialidade de Bioquímica (Thesis) Main arguer	Liliana Silva (Aggregation) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016	Provas de Agregação, em Biologia Celular e Molecular (Thesis) Main arguer	Elsa Bronze (Aggregation) Universidade do Porto Faculdade de Farmácia, Portugal
2013	Provas de Agregação em Bioquímica, na especialidade de Bioquímica Estrutural (Thesis) Main arguer	Cláudio Gomes (Aggregation) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012	Provas de Agregação em Farmácia, na especialidade de Biologia Celular e Molecular (Thesis) Main arguer	Alexandra Brito (Aggregation) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011	Provas de Agregação em Farmácia, na especialidade de Bioquímica (Thesis) Main arguer	Graça Soveral (Aggregation) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010	Provas de Agregação em Ciências da Saúde, na especialidade de Ciências Biomédicas (Thesis) Main arguer	Cristina Rego (Aggregation) Universidade de Coimbra Faculdade de Medicina, Portugal

Association member

	Society Organization name	Role
2013 - Current	Vice-presidente, FARM-ID - Associação da Faculdade de Farmácia para I&D	Vice-Presidente
1999 - Current	Member, American Association for the Study of Liver Diseases	Member
2013 - 2016	Governing Board, European Association Study of the Liver (EASL)	Governing Board Member (Scientific Committee)
2007 - 2011	Direção, Sociedade Portuguesa de Hepatologia	Membro da Direção
2003 - 2011	Direção, Sociedade Portuguesa de Neurociências	Membro da Direção

Committee member

	Activity description Role	Institution / Organization
2009 - Current	Membro, Conselho Científico da Faculdade de Farmácia, Universidade de Lisboa Member	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016	Membro, Conselho Científico das Ciências da Vida e da Saúde, Fundação para a Ciência e a Tecnologia (FCT), Portugal Member	Fundação para a Ciência e a Tecnologia, Portugal
2013 - 2016	Chair, Basic Science Concerted Action Group, European Association for the Study of the Liver Coordinator	European Association for the Study of the Liver, Switzerland
2014 - 2015	Vice-presidente, Conselho Científico da Faculdade de Farmácia, Universidade de Lisboa President / Vice-president	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2013	Membro, Comissão Executiva, Instituto de Investigação do Medicamento e Ciências Farmacêuticas Member	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Consulting

	Activity description	Institution / Organization
2014 - Current	Scientific Committee on Biosciences member, Santa Casa da Misericórdia de Lisboa	Santa Casa da Misericórdia de Lisboa, Portugal
2011 - Current	Scientific Advisory Board member, Metselex, Inc., USA
2014 - 2016	Basic Science Concerted Action Group chair, European Association for the Study of the Liver	European Association for the Study of the Liver, Switzerland
2013 - 2014	Basic Science Concerted Action Group member, European Association for the Study of the Liver	European Association for the Study of the Liver, Switzerland
2005 - 2011	Scientific Advisory Board member, SMG Therapeutics, Inc., USA

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020 - Current	Seminários/Seminars I - da Descoberta ao Uso do Medicamento	Ciências Farmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Current	Coordenador, Doutoramento em Farmácia	Farmácia (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Current	Biomarcadores e Tecnologias Moleculares/Molecular Biomarkers and Technologies	Farmácia (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Current	Coordenador, Mestrado em Ciências Biofarmacêuticas	Ciências Biofarmacêuticas (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Current	Sinalização Celular/Cell Sinalling	Ciências Biofarmacêuticas (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Current	Oncobiologgia/Oncobiology	Ciências Biofarmacêuticas (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
1999 - Current	Bioquímica II/Biochemistry II	Ciências Farmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2022	Diretor, FCT PhD Programme in Medicines and Pharmaceutical Innovation (i3DU)	FCT PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) (Doctor of Philosophy)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2014 - Current	Research projects, Agence Nationale de la Recherche Evaluator	Agence nationale de la recherche, France	Agence nationale de la recherche
2018 - 2020	Research Consortia and Projects (LiSyM – Systems Medicine of the Liver), Federal Ministry of Finance - BMBF, Germany Evaluator	Bundesministerium der Finanzen, Germany	Bundesministerium der Finanzen
2019 - 2019	Research Projects (Biological and Medical Sciences), Austrian Science Fund Evaluator	Fonds zur Förderung der wissenschaftlichen Forschung, Austria	Fonds zur Förderung der wissenschaftlichen Forschung
2017 - 2017	ERC Consolidator Grants, EU European Comission H2020 Specialist	European Research Council, Belgium	European Research Council
2009 - 2017	Postdoc and PhD fellowships, Fundação para a Ciência e a Tecnologia Evaluator	Fundação para a Ciência e Tecnologia, Portugal	Fundação para a Ciência e Tecnologia
2013 - 2016	Research fellowships (Post-doc, Physician Scientists, Entry-level, Short-term) and Mentorships, European Association for the Study of the Liver Evaluator	European Association for the Study of the Liver, Switzerland	European Association for the Study of the Liver
2015 - 2015	Research Perojects, Worldwide Cancer Research, UK Evaluator	Worldwide Cancer Research, United Kingdom	Worldwide Cancer Research
2015 - 2015	Research Projects, Centres of Excellence in Neurodegenerative disease (CoEN) Initiative	Deutsches Zentrum für Neurodegenerative Erkrankungen, Germany	Deutsches Zentrum für Neurodegenerative Erkrankungen
2008 - 2015	Research projects, Wellcome Trust, UK Evaluator	Wellcome Trust, United Kingdom	Wellcome Trust
2014 - 2014	European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases, EU Joint Programme Neurodegenerative Disease Research (JPND) Evaluator	EU Joint Programme Neurodegenerative Disease Research, Germany	EU Joint Programme Neurodegenerative Disease Research
2012 - 2014	Research projects, Alzheimer's Association, USA Evaluator	Alzheimer's Association, United States	Alzheimer's Association
2013 - 2013	European research projects on Genetic, Epigenetic and Environmental Risk Factors, European Joint Programme Neurodegenerative Disease Research Evaluator	EU Joint Programme Neurodegenerative Disease Research, Germany	EU Joint Programme Neurodegenerative Disease Research
2013 - 2013	Investigador FCT, Fundação para a Ciência e a Tecnologia Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2012 - 2012	Research projects, Research Foundation Flanders, Brussels	Fonds Wetenschappelijk Onderzoek Vlaanderen, Belgium	Fonds Wetenschappelijk Onderzoek Vlaanderen

Distinctions

Award

2023	Mulheres na Ciência 2023 Ciência Viva, Portugal
2022	2022 Sir Hans Krebs medal from FEBS
2016	University of Lisbon Scientific Prize (Biomedical Sciences)
2003	Francisco Pulido Valente Science Award (Neurosciences) Fundação para a Ciência e a Tecnologia, Portugal
2000	European Society for Pediatric Research Young Investigator Award
2000	European Association for the Study of the Liver Sheila Sherlock Award (Hepatology) European Association for the Study of the Liver, Switzerland
1999	European Association for the Study of the Liver Young Investigator Award European Association for the Study of the Liver, Switzerland
1992	Ordem dos Farmacêuticos Academic Merit Honour Ordem dos Farmaceuticos, Portugal

Other distinction

2021	Associate editor, Hepatology
2019	Editorial Board member, Journal of Hepatology
2019	Editorial Board member, Biomolecules (Chemical Biology section)
2019	Executive Editor, Journal of Physiology and Biochemistry
2016	Editorial Board member, Frontiers in Neuroscience (Neurodegeneration section)
2014	Editorial Board member (Founding Editor), Cell Stress
2011	Editorial Board member, Frontiers in Pharmacology (Experimental Pharmacology section)
2010	Associate Editor, Clinics and Research in Hepatology and Gastroenterology
2010	Associate Editor, Journal of Alzheimer's Disease
2004	Portuguese Nomination for the European Young Investigator Award Fundação para a Ciência e a Tecnologia, Portugal

	Event name Type of event (Role)	Institution / Organization
2018 - 2018	Basic Science Seminar “Targetable pathways in liver disease”, International Liver Congress 2018, European Association for the Study of the Liver (EASL), Paris, France (2018 - 2018) Seminar	European Association for the Study of the Liver, Switzerland
2016 - 2016	International Liver Congress 2016, European Association for the Study of the Liver (EASL), Barcelona, Spain (2016 - 2016) Congress (Co-organisor)	European Association for the Study of the Liver, Switzerland
2016 - 2016	Basic Science Seminar “Gut-liver Axis”, International Liver Congress 2016, European Association for the Study of the Liver (EASL), Barcelona, Spain (2016 - 2016) Seminar (Co-organisor)	European Association for the Study of the Liver, Switzerland
2016 - 2016	Joint Workshop “EASL-Cochrane Hepato-Biliary Group”, International Liver Congress 2016, European Association for the Study of the Liver, Barcelona, Spain (2016 - 2016) Workshop (Co-organisor)
2016 - 2016	XIX Congresso Nacional de Bioquímica, da Sociedade Portuguesa de Bioquímica, Guimarães, Portugal (2016 - 2016) Congress (Member of the Scientific Committee)	Sociedade Portuguesa de Bioquímica, Portugal
2015 - 2015	The International Liver Congress 2015, European Association for the Study of the Liver (EASL), Vienna, Austria. (2015 - 2015) Congress	European Association for the Study of the Liver, Switzerland
2015 - 2015	EASL-FLIP Joint Workshop on Advances in pathogenesis, diagnosis and clinical hotspots, International Liver Congres 2015, European Association for the Study of the Liver. International Liver Congress, Vienna, Austria. (2015 - 2015) Workshop (Co-organisor)
2015 - 2015	Seminar “Young Investigator Seminar – Liver Cell Death", International Liver Congress 2015, European Association for the Study of the Liver, Vienna, Austria. (2015 - 2015) Seminar (Co-organisor)	European Association for the Study of the Liver, Switzerland
2014 - 2014	The International Liver Conggress, European Association for the Study of the Liver (EASL), London, UK, 2014 (2014 - 2014) Congress (Co-organisor)	European Association for the Study of the Liver, Switzerland
2014 - 2014	EASL-I-PSC-SG (International PSC Study Group) Joint Workshop, International Liver Congress 2014, European Association for the Study of the Liver., London, UK. (2014 - 2014) Workshop (Co-organisor)	European Association for the Study of the Liver, Switzerland
2013 - 2013	Translational Workshop “Modulation of Liver Injury and Metabolism Through Bile Acid Receptors”, International Liver Congress of the European Association for the Study of the Liver 2013, Amsterdam, Holland. (2013 - 2013) Workshop (Co-organisor)	European Association for the Study of the Liver, Switzerland
2010 - 2010	Simpósio “Redox, Stress and Cell Death”, XVII Congresso Nacional de Bioquímica 2010, Porto, Portugal (2010 - 2010) Symposium (Member of the Scientific Committee)	Sociedade Portuguesa de Bioquímica, Portugal
2006 - 2006	Simpósio “Neurobiologia”, Congresso Nacional de Bioquímica 2006, Aveiro, Portugal (2006 - 2006) Symposium (Member of the Scientific Committee)	Sociedade Portuguesa de Bioquímica, Portugal
2004 - 2004	Simpósio “Neuroquímica”, XIV Congresso Nacional de Bioquímica 2004, Vilamoura, Portugal (2004 - 2004) Symposium (Member of the Scientific Committee)	Sociedade Portuguesa de Bioquímica, Portugal
1998 - 1998	Symposium “Update on bilirubin errors and new therapies”, 33rd Annual Meeting of the European Association for the Study of the Liver 1998, Lisbon, Portugal (1998 - 1998) Symposium (Member of the Organising Committee)	European Association for the Study of the Liver, Switzerland