Carlos Adriano Albuquerque Andrade de Matos (DC14-C299-222A)

Curriculum Vitae

Carlos Adriano Albuquerque Andrade de Matos

Carlos Matos earned a PhD in Cell Biology in 2015 at the University of Coimbra, and he has since been professionally dedicated to teaching and research, first at the University of Coimbra, and since 2019 at the University of Algarve. Carlos Matos is currently Assistant Professor at the Faculty of Medicine and Biomedical Sciences, University of Algarve, where he teaches various Course Units in the areas of Cell and Molecular Biology, Physiology, Histology, Neurobiology, Pharmacology, Gene and Cell Therapy, Drug Discovery and Laboratory Techniques. Carlos Matos research activity has focused on identifying new therapeutic targets for rare neurodegenerative diseases, generating new disease models and preclinical design and testing of pharmacological therapies and advanced therapies for this type of nervous system pathologies. So far Carlos Matos has published a total of 24 articles in international journals. He is co-author (and illustrator) of a book, the “Handbook of Gene and Cell Therapy,” having also co-produced 2 book chapters on Gene Therapy. In 2019, Carlos Matos obtained funding for a research project worth $15,000, awarded by the United States of America's National Ataxia Foundation, and in 2022 he obtained €20,000 to develop two research projects, assigned by the Algarve Biomedical Center. In August 2024, Carlos Matos earned funding of €48,950 as a Principal Investigator to develop an exploratory project, assigned by the Portuguese Foundation for Science and Technology. Carlos Matos is or has been a supervisor of 6 PhD students, 13 Master's and 23 Bachelor's students. So far he has participated in 41 juries of academic degrees, and he is the author of more than 40 oral communications and more than 50 posters, presented at national and international scientific events. Carlos Matos is an effective member of the Portuguese Society of Pharmacists (OF), the Portuguese Society of Pharmacology (SPF), the Portuguese Society of Neuroscience (SPN), the European Federation of Neuroscience Societies (FENS) and the European Society of Gene & Cell Therapy (ESGCT). In 2021, he hosted an international workshop on gene editing at the University of Algarve, and in 2023 he co-organized the FENS Regional Meeting 2023 – Algarve, a scientific conference with world projection. In February 2023, Carlos Matos was honored to be invited to make a speech on genome edition, as an expert, by the National Board of Ethics for Life Sciences (CNECV), under the State of Application Report of New Human Life Technologies 2022 “Disruptive technologies in Health,” in Faro. In 2023 and 2024, Carlos Matos was awarded with the University of Algarve Teaching Award – Professor of the Year distinguished by Students, referring to the 2021/22 and 2023/2024 school years, respectively.

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Identification

Personal identification

Full name: Carlos Adriano Albuquerque Andrade de Matos

Citation names

Matos, Carlos A

Author identifiers

Ciência ID: DC14-C299-222A
ORCID iD: 0000-0002-9019-7569

Websites

https://orcid.org/0000-0002-9019-7569 (Professional)
www.linkedin.com/in/ca3matos (Social media)
https://fmcb.ualg.pt/bio/camatos (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Biology
Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Cell Biology
Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Basic Medicine - Physiology
Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Medical and Health Sciences - Basic Medicine - Human Genetics

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Japanese	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)		Intermediate (B1)
French		Beginner (A1)

Education

	Degree	Classification
2023/12/21 Concluded	Integrated Master in Pharmaceutical Sciences (Mestrado) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal "Antibiotherapy of infections caused by multidrug-resistant Gram-positive cocci" (THESIS/DISSERTATION)	18
2017 Concluded	EMBO Practical Course on Mouse Genome Engineering (Outros) Max-Planck-Institut für molekulare Zellbiologie und Genetik, Germany
2015/02/03 Concluded	PhD in Biology, speciality of Cell Biology (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Regulation of ataxin-3 by phosphorylation: Relevance for Machado-Joseph disease" (THESIS/DISSERTATION)	Approved with Distinction and Honors, by unanimity
2014 Concluded	Laboratory Animal Sciences Course - B Category (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Certified
2010 Concluded	Science Communication (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009 Concluded	Master's degree in Molecular Cell Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Post-translational modifications of ataxin-3, the protein involved in Machado-Joseph disease: evidences for phosphorylation and sumoylation" (THESIS/DISSERTATION)	19
2009 Concluded	Neurodegenerative Disorders (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007 Concluded	Bachelor's degree in Biology (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Not applicable" (THESIS/DISSERTATION)	18

Affiliation

Science

	Category Host institution	Employer
2019/02/26 - 2022/02/25	Contracted Researcher (Research)	Universidade do Algarve, Portugal
	Universidade do Algarve, Portugal
2015/02/04 - 2019/01/31	Postdoc (Research)	CNC.IBILI, Portugal

2013/10/03 - 2015/09/30	Researcher (Research)	CNC.IBILI, Portugal

2008/09/01 - 2008/11/30	Researcher (Research)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2025/12/02 - Current	Assistant Professor (University Teacher)	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2022/03/04 - 2025/12/01	Invited Assistant Professor (University Teacher)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2019	Invited Assistant Professor (University Teacher)	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Others

	Category Host institution	Employer
2009 - 2013	PhD Student	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	CNC.IBILI, Portugal
2007 - 2009	MSc Student	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	CNC.IBILI, Portugal

Projects

Grant

	Designation	Funders
2023 - Current	AdvGT-CSB – Advancing the development of a gene therapy for Cockayne Syndrome AdvGT-CSB	Viljem Julijan Association for Children with Rare Diseases Ongoing
2021/09/01 - Current	Assessment of experimental therapies in pre-clinical studies of Cockayne Syndrome #431	Ongoing
2022/05/05 - 2023/05/05	Cockayne syndrome: pioneer exploration of a gene therapy-based approach to the treatment of a neglected disease Not applicable Principal investigator Algarve Biomedical Center Research Institute, Portugal	Algarve Biomedical Center Concluded
2022/05/05 - 2023/05/05	Explore the mechanisms behind neurodegenerative rare disorders - is mitosis on the aetiology of these diseases? Not applicable Co-Principal Investigator (Co-PI) Algarve Biomedical Center Research Institute, Portugal	Algarve Biomedical Center Concluded
2019/03/01 - 2020/10/01	Silencing the SCA3-causing gene ATXN3 through CRISPR interference 616430 Principal investigator CNC.IBILI, Portugal	National Ataxia Foundation Concluded
2020 - 2020	Development of a new assay do detect SARS-CoV-2 directly from clinical samples 126_596760136 Researcher Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019 - 2020	Overexpression of the RNA-binding protein G3BP1 as a therapeutic strategy to Machado-Joseph disease and other Polyglutamine diseases Not applicable	AFM-Téléthon Concluded
2018 - 2019	SeGrPolyQ – The role of stress granules in Polyglutamine diseases: from pathogenesis to molecular therapy Not applicable Post-doc Fellow	Fundação para a Ciência e a Tecnologia Concluded
2018 - 2019	ZUNIALGA – Neuroprotective therapeutic approach for Spinocerebellar Ataxia type 2: pharmacological targeting of AMPK ZUNIALGA	Ataxia UK Concluded
2017 - 2019	BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias CENTRO-01-0145-FEDER-000008 Post-doc Fellow CNC.IBILI, Portugal	European Regional Development Fund Concluded
2016 - 2019	Advanced models of polyglutamine disorders (Huntington's disease, SCA3 and SCA7) JPCOFUND/0005/2015 Post-doc CNC.IBILI, Portugal	Horizon 2020 Concluded
2016 - 2017	SYNSPREAD - Roles and mechanisms of synuclein and ataxin3 spreading in Parkinson and Machado-Joseph diseases JPND-CD/0001/2013 Post-doc Fellow CNC.IBILI, Portugal	Horizon 2020 Concluded
2015 - 2016	Financiamento Incentivo 2014 Incetivo/SAU/LA0001/2014 Post-doc Fellow	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2015	A novel model for Schizophrenia: defects in stargazing-mediated homeostatic plasticity PTDC/NEU-NMC/0750/2012 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2014	Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease PTDC/SAU-NMC/110602/2009 Researcher CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/10/01 - 2013/09/30	ANALYSIS OF SYNAPTIC DYSFUNCTION AND ATAXIN-3 PHOSPHORYLATION IN A MOUSE MODEL OF MACHADO-JOSEPH DISEASE SFRH/BD/47160/2008	Fundação para a Ciência e a Tecnologia Concluded
2008 - 2008	Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph's disease POCI/SAU-MMO/60156/2004 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2024 - Current	AgeTech – Investigação de Novos Compostos para o Desenvolvimento Inovador de Produtos Cosméticos de Anti-Envelhecimento COMPETE2030-FEDER-01193900	Comissão de Coordenação e Desenvolvimento Regional do Algarve Ongoing
2022 - Current	Laboratório Colaborativo do Algarve Biomedical Center: Soluções Integradas para o Envelhecimento e Rejuvenescimento (ABC CoLAB – Ageing Better) ABC CoLAB – Ageing Better	Fundação para a Ciência e a Tecnologia Ongoing
2025/02/03 - 2026/08/02	Testing efficacy and safety of a gene therapy for Cockayne syndrome type B in patient-derived cell models 2023.15884.PEX 10.54499/2023.15884.PEX Principal investigator Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/01 - 2022/06/30	Blocking neurodegeneration by spreading of gene silencers PTDC/BTM-SAL/29716/2017 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book	Nóbrega, Clévio; Mendonça, Liliana; Matos, Carlos A.. A Handbook of Gene and Cell Therapy. Switzerland: Springer International Publishing. 2020. Published • 10.1007/978-3-030-41333-0
Book chapter	M. Codêsso, José; A. Matos, Carlos; Nóbrega, Clévio. "RNA Interference Applications for Machado-Joseph Disease". In RNA Therapeutics - History, Design, Manufacturing, and Applications. St. Louis, United States: IntechOpen, 2022. Published • 10.5772/intechopen.109261 Matos, Carlos A.; Carmona, Vítor; Vijayakumar, Udaya-Geetha; Lopes, Sara; Albuquerque, Patrícia; Conceição, Mariana; Nobre, Rui Jorge; Nóbrega, Clévio; de Almeida, Luís Pereira. "Gene Therapies for Polyglutamine Diseases". In Advances in Experimental Medicine and Biology, 395-438. Springer International Publishing, 2018. Published • 10.1007/978-3-319-71779-1_20
Conference abstract	Serra Patrão, Raquel; Pereira, Isabel; Matos, Carlos A; Conceição, J.. "Anticoagulantes orais diretos: Contexto histórico e impacto na prática clínica atual". Paper presented in 4.º Congresso Internacional de História da Ciência no Ensino, On-line, 2025. Published Serra Patrão, Raquel; Pereira, Isabel; Matos, Carlos A; Conceição, J.. "Evolução dos métodos laboratoriais para o diagnóstico da síndrome antifosfolipídica". Paper presented in 4.º Congresso Internacional de História da Ciência no Ensino, On-line, 2025. Published Serra Patrão, Raquel; Pereira, Isabel; Matos, Carlos A; Conceição, J.. "Abordagem Integrada no Diagnóstico da Síndrome Antifosfolipídica: A Importância Laboratorial para a Deteção de Anticorpos Antifosfolipídicos". Paper presented in Congresso APTAC 2025, Associação Portuguesa dos Técnicos de Análises Clínicas e Saúde Pública, Lisboa, 2025. Published Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Sofia M. Calado; Matos, Carlos A. Corresponding author: Matos, Carlos A. "Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B". Paper presented in Meeting of the Portuguese Society of Pharmacology (SPF Meeting), Lisbon, 2024. Published Matos, Carlos A; Conceição, Jaime; Nóbrega, Clévio. "Terapia Génica e Celular: História e inovação no ensino das Ciências Biomédicas na Universidade do Algarve". Paper presented in 3.º Congresso Internacional de História da Ciência no Ensino, Faro, 2023. Published Afonso, Inês T.; Lima, Patrícia; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Ataxin-2 pathological features are altered by the aging process". Paper presented in 25th Annual Meeting of the Portuguese Society of Human Genetics, Porto, 2022. Published Sara Lopes; Miguel Lopes; Rui Nobre; Clévio Nóbrega; Matos, Carlos A; Ana Vasconcelos-Ferreira; Neville Sanjana; et al. "Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), Lisbon, 2021. Published Adriana Marcelo; Ana Rosa; Marta Santos; Benedita Ferreira; Rebekah Koppenol; Matos, Carlos A; Clévio Nóbrega. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2021. Published Ricardo Reis; Rebekah Koppenol; Luís Pereira de Almeida; Matos, Carlos A; Clévio Nóbrega. "Silencing ATXN2 expression using CRISPR/Cas9". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2021. Published Conceição, André; Koppenol, Rebekah; Tomé, Sandra; Carmo-Silva, Sara; Matos, Carlos A; Pereira de Almeida, Luis Fernando Morgado; Nóbrega, Clévio David Rodrigues. "A RNA binding protein alleviates pathology in two different mouse models of polyglutamine diseases.". Paper presented in 24th Anual Meeting of Portuguese Human Genetics Society. Proceedings published in Medicine, 2021. Published • 10.1097/MD.0000000000023585 André Conceição; Raquel Koppenol; Joana Silva; Ricardo Reis; José Codesso; Sandra Tomé; Sara Carmo-Silva; et al. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society for Human Genetics (SPGH), Lisbon, 2020. Published Matos, Carlos A; Pena, Frederico; Conceição, André; Sara M. Lopes; Sónia P. Duarte; Miranda, CO; Pereira de Almeida, Luis. "CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI2019), Coimbra, Portugal, Coimbra, 2019. Published • 10.1111/eci.13108
Conference paper	Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos A; Nóbrega, Clévio. "From the molecular hallmarks to motor behavior: characterization of a new transgenic mouse model for spinocerebellar ataxia type 2". 2023. 10.1111/jnc.15896 Perdigão, PRL; Matos, Carlos A; Sara M. Lopes; Fernandes, Ana Rita; Miguel M. Lopes; Conceição, André; Faro, Rosario; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair". Paper presented in 26th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2022. 10.1097/MD.0000000000033154 Afonso, Inês T.; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Ataxin-2 pathological features are altered by the aging process". Paper presented in 25th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2021. 10.1097/MD.0000000000029313 Conceição, André; Koppenol, Rebekah; Carmo-Silva, Sara; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics, 2020. 10.1097/MD.0000000000023585 Sara M. Lopes; Miguel M. Lopes; Nobre, Rui; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Vasconcelos-Ferreira, Ana; Pereira de Almeida, Luis. "Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020. 10.1097/MD.0000000000023585 Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020. 10.1097/MD.0000000000023585 Afonso-Reis, Ricardo; Koppenol, Rebekah; Pereira de Almeida, Luis ; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Silencing ATXN2 expression using CRISPR/Cas9". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020. 10.1097/MD.0000000000023585 Nóbrega, Clévio David Rodrigues ; Mendonça, Liliana; Correia, M.; Matos, Carlos A; Pereira de Almeida, Luis. "CYP46A1- gene therapy improves Machado-Joseph disease in mouse models". Paper presented in 23rd Annual Meeting of the Portuguese Society of Human Genetics, 2019. 10.1097/MD.0000000000019291
Conference poster	Cristiana R. Madeira; Koppenol, Rebekah; Afonso-Reis, Ricardo; Sofia M. Calado; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "ATXN2 silencing mediated by CRISPR interference mitigates pathological traits in spinocerebellar ataxia type 2 patient-derived neurons". Paper presented in European Society of Gene and Cell Therapy, 2025. Patrão, Raquel Serra; Pereira, Isabel; Soares, Isabel; Matos, Carlos A; Conceição, J.. "Abordagem integrada no diagnóstico da sindrome antifosfolipídica: a importância laboratorial para a deteção de anticorpos antifosfolipídicos.". Paper presented in Congresso 40 anos da Associação Portuguesa de Técnicos de Análises clínicas (APTAC), 2025. Costa, Rafael; Outeiro, Tiago; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Extracellular Vesicles as Carriers of ATXN2 mRNA: Implications for SCA2 Progression". Paper presented in Portuguese Network on Extracellular Vesicles (PNEV) 2025, 2025. Lopes, Sara M.; Miguel M. Lopes; Santana, Magda M; Oliveira, Daniela; Fernandes, Ana Rita; Casquinha, Maria; Vasconcelos-Ferreira, Ana; et al. "CRISPR-Cas9-Mediated ATXN3 Gene Inactivation as a Promising Gene Therapy for Machado-Joseph Disease". Paper presented in 28th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), 2025. Cristiana R. Madeira; Afonso-Reis, Ricardo; Matos, Carlos A; Sofia M. Calado; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Establishment of a novel patient-derived iPSC-based Neuronal Model for Cockayne Syndrome B". Paper presented in XIX Meeting of the Portuguese Society for Neuroscience, 2025. Costa, Rafael; Outeiro, Tiago; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "ATXN2 mRNA shuttling to exosomes: a mechanism underlying pathogenesis?". Paper presented in Gordon Research Conference on CAG Triplet Repeat Disorders 2025, 2025. Koppenol, Rebekah; Afonso-Reis, Ricardo; Sofia M. Calado; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "CRISPRi-mediated silencing of ATXN2 to mitigate pathological features in Spinocerebellar ataxia type 2 patient-derived neurons". Paper presented in Gordon Research Conference - CAG Triplets, 2025. Lopes, Sara M. ; Miguel M. Lopes; Oliveira, AD; Santana, Magda M; Fernandes, Ana Rita; Vasconcelos-Ferreira, Ana; Pereira, Dina; et al. "Therapeutic Potential of CRISPR-Cas9-Mediated ATXN3 Gene Inactivation in Machado-Joseph Disease.". Paper presented in Rare Disease Research Conference 2025, 2025. Serra Patrão, Raquel; Pereira, Isabel; Soares, Isabel; Matos, Carlos A; Conceição, J.. "Factor V Leiden and Pregnancy Loss: A Clinical Case Report". Paper presented in 29th International Congress on Thrombosis, 2025. Serra Patrão, Raquel; Pereira, Isabel; Matos, Carlos A; Conceição, J.. "Impact of Plasminogen Activator Inhibitor-1 Homozygosity in Obstetric Context: Report of Three Clinical Cases". Paper presented in 29th International Congress on Thrombosis, 2025. Cristiana R. Madeira; Matos, Carlos. "Development and characterization of a novel SCA2 patient-derived induced pluripotent stem cell model as a tool to investigate therapeutic strategies.". Paper presented in International Conference for Ataxia Research (ICAR), 2024. Matos, Carlos A; Conceição, J.; Nóbrega, Clévio David Rodrigues. "History and innovation in the teaching of Gene and Cell Therapy at the University of Algarve". Paper presented in 19.º Congresso da Sociedade Portuguesa de Neurorradiologia Diagnóstica e Terapêutica (SPNR), 2024. Rafael G. Costa; Matos, Carlos A; Outeiro, Tiago; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Small EVs as molecular carriers: ATXN2 mRNA spreading recapitulates neuropathological hallmarks of spinocerebellar ataxia type 2". Paper presented in Gordon Research Conference on Extracellular Vesicles, 2024. Costa, Rafael G; Martins, Jéssica; Matos, Carlos A; Outeiro, Tiago; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "Mechanisms of Spinocerebellar Ataxia Type 2 Pathogenesis: Insights from Small Extracellular Vesicles". Paper presented in FENS Forum 2024, 2024. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Codêsso, José Miguel; Mendonça, Liliana; et al. "Stress Granules: How do they impact spinocerebellar ataxia type 2?". Paper presented in Federation of European Neurosciences (FENS) Forum 2024, 2024. Koppenol, Rebekah; Pereira de Almeida, Luis ; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "CRISPR-mediated approaches for ATXN2 knockdown in SCA2 models of disease". Paper presented in Federation of European Neurosciences (FENS) Forum 2024, 2024. Conceição, André; Koppenol, Rebekah; Afonso, Inês T.; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Unveiling SCA2 disease phenotype: a new mouse model reveals motor deficits and neuropathology". Paper presented in Sociedade Portuguesa de Genética Humana, 2023. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Corresponding author: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Paper presented in 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023. Conceição, André; Koppenol, Rebekah; Inês Afonso; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos; Nóbrega, Clévio David Rodrigues. "A novel SCA2 transgenic mouse model displays disease-associated phenotype.". Paper presented in FENS Regional Meeting 2023 – Algarve, 2023. Koppenol, Rebekah; Matos, Carlos A; Afonso-Reis, Ricardo; de Almeida, Luis Pereira; Nóbrega, Clévio David Rodrigues. "Tackling spinocerebellar ataxia type 2: targeting the ATXN2 gene with CRISPR-Cas-based silencing strategies.". Paper presented in FENS Regional Meeting 2023 – Algarve, 2023. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells.". Paper presented in FENS Regional Meeting 2023 – Algarve, 2023. Cristiana R. Madeira; Afonso-Reis, Ricardo; Nóbrega, Clévio David Rodrigues ; Matos, Carlos A; Sofia M. Calado. "Neuronal cultures differentiated from patient-derived induced pluripotent stem cells as a novel model of Cockayne syndrome B.". Paper presented in European Neuroscience Conference by Doctoral Students (ENCODS) Meeting 2023, 2023. Afonso, Inês T.; Koppenol, Rebekah; Conceição, André; Vieira R; Paulino, Rodrigo; Mirapelha, L.; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "From the molecular hallmarks to motor behavior: characterization of a novel transgenic mouse model for Spinocerebellar ataxia type 2". Paper presented in ISN-ESN, 2023. Afonso-Reis Ines; Koppenol, Rebekah; Conceição, André; Vieira Romulo; Paulino, Rodrigo; Mirapalheta, Lourenzo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "the molecular hallmarks to motor behavior: characterization of a novel transgenic mouse model for Spinocerebellar ataxia type 2". Paper presented in ISN-ESN, 2023. Rafael G. Costa; Afonso, Inês T.; Afonso-Reis, Ricardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues . Corresponding author: Nóbrega, Clévio David Rodrigues. "The role of a stress granules' component as a modulator of progerin's expression: a prospective approach to slow down accelerated aging in HGPS cells". Paper presented in Ageing Without Borders 2022, 2022. Perdigão, PRL; Matos, Carlos A; Lopes, Sara M. ; Fernandes, Ana Rita; Miguel M. Lopes; Conceição, A; Faro, R; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9 homology directed repair.". Paper presented in 26th Annual Portuguese Society of Human Genetics Meeting, 2022. Perdigão, P; Matos, Carlos A; Lopes, Sara; Fernandes, Ana Rita; Lopes, Miguel; Conceição, André; Faro, Rosario; et al. "Modelling Machado-Joseph Disease in patient-derived isogenic lines by CRISPR/Cas9-mediated correction of ATXN3-CAG expansion". Paper presented in ESGCT 29th Annual Congress, European Society of Gene and Cell Therapy, Edinburgh, 2022, 2022. Conceição, André; Koppenol, Rebekah; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Tomé, Sandra; Codêsso, José Miguel; et al. "A expressão da proteína G3BP1 reduz as anomalias neuropatológicas e motoras em modelos da Ataxia espinocerebelosa, tipo 3". Paper presented in Congresso SPDMov 2022, 2022. Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Afonso-Reis, Ricardo; Costa, Rafael G; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "Motor phenotype characterization of a new transgenic mouse model for Spinocerebellar ataxia type 2.". Paper presented in ABC Days - V National Meeting of the Algarve Biomedical Center, 2022. Marcelo, Adriana. "Autophagy induction mitigates Spinocerebellar ataxia type 2 disease hallmarks.". Paper presented in Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms, 2022. Conceição, André. "Expression of G3BP1 reduces neuropathological and motor abnormalities in models of spinocerebeçllar ataxia type 3". Paper presented in Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms, 2022. Koppenol, Rebekah. "Development of CRISPR-Cas-based strategies for spinocerebellar ataxia type 2.". Paper presented in European Society of Gene and Cell Therapy (ESGCT) 29th congress in collaboration with British Society for Gene and Cell Therapy (BSGCT), 2022. Koppenol, Rebekah; Conceição, André; Marcelo, Adriana; Afonso-Reis, Ricardo; Afonso, Inês T.; Codêsso, José Miguel; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "G3BP1 expression mitigates pathological phenotype in mouse models different polyglutamine diseases". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. Afonso-Reis, Ricardo; Koppenol, Rebekah; Conceição, André; Teixeira, Diogo; Marcelo, Adriana; Tomé, Sandra; Carmo-Silva, Sara; et al. "ASSESSING THE ROLE OF DIFFERENT G3BP1 REGIONS IN THE MITIGATION OF THE PATHOLOGICAL PHENOTYPE IN SCA2 AND SCA3 DISEASE MODELS". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. "An RNA-binding protein alleviates pathology in two different mouse models of polyglutamine diseases". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2021. "Development of a gene based strategy as a potential therapy for Hutchinson Gilford Progeria Syndrome". Paper presented in Annual International (bio)Medical Students (AIMS) Meeting, 2021. "Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models". Paper presented in IV Jornadas Algarve Biomedical Center, 2021. "G3BP1 as a therapeutic target for spinocerebellar ataxias: mitigation of pathological traits in different mouse models". Paper presented in IV Jornadas Algarve Biomedical Center, 2021. "Is mutant ataxin-2 aggregation modulated by aging?". Paper presented in IV Jornadas Algarve Biomedical Center, 2021. "Assessing the Role of G3bp1 Domains in the Mitigation of the Pathological Phenotype in SCA2 and SCA3 Disease Models". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. "Precise and scarless correction of ATXN3-CAG expansion by CRISPR/Cas9 for the generation of patient-derived MJD isogenic iPSC.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. "From molecular mechanisms to therapy: a new lentiviral mouse model for Spinocerebellar ataxia type 2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. "G3BP1 expression mitigates pathological phenotype in mouse models of different polyglutamine diseases". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. "Generation of a novel transgenic mouse model of spinocerebellar ataxia type 2 expressing mutant ATXN2 in cerebellar Purkinje cells". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. Brito, David V.C.; Afonso, I; Matos, Carlos A; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Targeting the NMDAR/TRPM4 complex as a novel therapeutic strategy for polyglutamine spinocerebellar ataxia type 2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. "Impact of aging in neuropathological hallmarks associated with the expression of mutant ATAXIN-2". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (SPN), 2021. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Striatal neuropathology in spinocerebellar ataxia type 2: a new lentiviral mouse model". Paper presented in FENS 2020 Virtual Forum, 2020. Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. "A lentiviral genetic mouse model for Spinocerebellar ataxia type 2". Paper presented in International Meeting of the Portuguese Society of Genetics, 2020. "Silencing ATXN2 expression using CRISPR/Cas9". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020. "Autophagy impairment in spinocerebellar ataxia type 2: first evidences and a potential therapeutic strategy". Paper presented in 24th Annual Meeting of the Portuguese Society of Human Genetics (SPGH), 2020. Sara Lopes; Matos, Carlos A; André Conceição; Frederico Pena; Miguel Lopes; Rui Nobre; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease". Paper presented in 2019 International Machado-Joseph Research Disease Conference, Washington, 2019. Sara Lopes; Matos, Carlos A; André Conceição; Frederico Pena; Miguel Lopes; Rui Nobre; Nóbrega, Clévio; et al. "CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph disease.". Paper presented in 3rd International Ataxia Research Conference (IARC), Washington, DC, USA., 2019. Matos, Carlos A; André Conceição; Sara Lopes; Luis Pereira de Almeida. "CRISPR-CAS9 as a tool for silencing and correcting ATXN3, the gene causing Machado-Joseph disease.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019. Matos, Carlos A; André Conceição; Frederico Pena; Sara Lopes; Sónia Duarte; Catarina Miranda; Luís Pereira de Almeida. "Transcriptional repression of mutant human ATNX3 using CRISPR interference mitigates the pathological phenotype of an in vivo Machado-Joseph disease model.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019. Rebekah Koppenol; Adriana Marcelo; Matos, Carlos A; Sara Carmo-Silva; Luis Pereira de Almeida; Clévio Nóbrega. "On the role of stress granules in autophagy.". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019. Matos, Carlos A. "CYP46A1-gene therapy alleviates Machado-Joseph disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019. Matos, Carlos A. "RNA-binding proteins: new molecular targets for polyglutamine diseases?". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal, 2019. Matos, Carlos A. "CRISPR-Cas9-mediated pre-transcriptional silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model". Paper presented in 22nd Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Washington, DC, USA, 2019. Matos, Carlos A. "Ibuprofen improves neuropathology and increases neural progenitors proliferation, synaptic function and neurite growth in Machado-Joseph disease.". Paper presented in 2nd International Ataxia Research Conference (IARC), Pisa, Italy, 2017. Matos, Carlos A. "TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease". Paper presented in 2nd International Ataxia Research Conference (IARC), Pisa, Italy, 2017. Matos, Carlos A. "CRISPR-Cas9 as a tool for Machado-Joseph disease treatment and animal model generation". Paper presented in EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany, 2017. Matos, Carlos A. "Modulation of catalytic activity and polyQ toxicity by phosphorylation in spinocerebellar ataxia type 3". Paper presented in 5th Ataxia Investigators Meeting, Las Vegas, USA, 2014. Matos, Carlos A. "Post-translational modifications and polyglutamine diseases: the effects of ataxin-3 phosphorylation". Paper presented in Champalimaud Neuroscience Programme Symposium, Lisbon, Portugal, 2013. Matos, Carlos A. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Paper presented in XIII Meeting of the Portuguese Society for Neuroscience (SPN), Luso, Portugal, 2013. Matos, Carlos A. "Ataxin-3 phosphorylation and its effects on protease activity and Machado-Joseph disease mechanisms". Paper presented in X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Cantanhede, Portugal, 2012. Matos, Carlos A. "Regulation by phosphorylation of ataxin-3, the mutated protein in Machado-Joseph disease". Paper presented in 8th Federation of European Neurosciences (FENS) Forum of Neuroscience, Barcelona, Spain, 2012. Matos, Carlos A. "Regulation by phosphorylation of ataxin-3, the mutated protein in Machado-Joseph disease". Paper presented in Gordon Research Conference on CAG Triplet Disorders, Luca, Italy, 2011.
Journal article	Matos, Carlos A.; Ali, Nuro; Augusto, André; Algarvio, Rogério; Figueirinha, João; Conceição, Jaime. "Predictive value of the hERG assay for anticipating the arrhythmogenic potential of new drugs". Drug Discovery Today 31 2 (2026): 104615. https://doi.org/10.1016/j.drudis.2026.104615. 10.1016/j.drudis.2026.104615 Clévio Nóbrega; Adriana Marcelo; Ana Teresa Rajado; André Conceição; Bernardo Estevam; Carlos A. Matos; David VC Brito; et al. "Molecular hallmarks of neurodegeneration in polyglutamine spinocerebellar ataxias". Cell Death & Disease (2025): https://doi.org/10.1038/s41419-025-08154-2. 10.1038/s41419-025-08154-2 Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Andrade, Raquel P.; et al. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research 81 (2024): 103576. https://doi.org/10.1016/j.scr.2024.103576. 10.1016/j.scr.2024.103576 Rafael G. Costa; André Conceição; Carlos A. Matos; Clévio Nóbrega. "The polyglutamine protein ATXN2: from its molecular functions to its involvement in disease". Cell Death & Disease (2024): https://doi.org/10.1038/s41419-024-06812-5. 10.1038/s41419-024-06812-5 Brito, D. V. C.; Esteves, F.; Rajado, A. T.; Silva, N.; Andrade, R.; Apolónio, J.; Calado, S.; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". NPJ Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6. 10.1038/s41514-023-00120-6 Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David; Apolónio, Joana; Roberto, Vânia Palma; Binnie, Alexandra; et al. "Measuring healthy ageing: current and future tools". Biogerontology 24 6 (2023): 845-866. https://doi.org/10.1007/s10522-023-10041-2. 10.1007/s10522-023-10041-2 Rajado, Ana Teresa; Silva, Nádia; Esteves, Filipa; Brito, David; Binnie, Alexandra; Araújo, Inês M.; Nóbrega, Clévio; Bragança, José; Castelo-Branco, Pedro. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): http://dx.doi.org/10.18632/aging.204668. 10.18632/aging.204668 Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio. "PolyQ Database - an integrated database on polyglutamine diseases". Database 2023 (2023): http://dx.doi.org/10.1093/database/baad060. 10.1093/database/baad060 Esteves, Filipa; Brito, David; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vania Palma; Araújo, Inês Maria; et al. "Reprogramming iPSCs to study age-related diseases: models, therapeutics, and clinical trials". (2023): http://hdl.handle.net/10400.1/20141. 10.1016/j.mad.2023.111854 Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain 146 6 (2022): 2346-2363. http://dx.doi.org/10.1093/brain/awac473. 10.1093/brain/awac473 Marcelo, Adriana; Matos, Carlos A.; Nóbrega, Clévio. "Autophagy is dysregulated in spinocerebellar ataxia type 2". Autophagy Reports 1 1 (2022): 179-182. http://dx.doi.org/10.1080/27694127.2022.2065603. 10.1080/27694127.2022.2065603 Afonso, Inês T.; Lima, Patrícia; Conceição, André; Matos, Carlos A; Nóbrega, Clévio. "Mutant Ataxin-2 expression in aged animals aggravates neuropathological features associated with Spinocerebellar Ataxia type 2". (2022): http://hdl.handle.net/10400.1/18390. 10.3390/ijms231911896 Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease 12 12 (2021): http://dx.doi.org/10.1038/s41419-021-04404-1. 10.1038/s41419-021-04404-1 Adriana Marcelo; Rebekah Koppenol; Luís Pereira de Almeida; Carlos A. Matos; Clévio Nóbrega. "Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?". Cell Death & Disease 12 6 (2021): https://doi.org/10.1038/s41419-021-03873-8. Open access • Published • 10.1038/s41419-021-03873-8 Nóbrega, Clévio; Conceição, André; Costa, Rafael G.; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; et al. "The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease". BMC Research Notes 13 1 (2020): http://dx.doi.org/10.1186/s13104-020-05053-x. 10.1186/s13104-020-05053-x Nóbrega, Clévio; Mendonça, Liliana; Marcelo, Adriana; Lamazière, Antonin; Tomé, Sandra; Despres, Gaetan; Matos, Carlos A.; et al. "Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia". Acta Neuropathologica 138 5 (2019): 837-858. http://dx.doi.org/10.1007/s00401-019-02019-7. 10.1007/s00401-019-02019-7 Mendonça, Liliana S; Nóbrega, Clévio; Tavino, Silvia; Brinkhaus, Maximilian; Matos, Carlos; Tomé, Sandra; Moreira, Ricardo; et al. "Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado–Joseph disease models". Human Molecular Genetics 28 22 (2019): 3691-3703. http://dx.doi.org/10.1093/hmg/ddz097. 10.1093/hmg/ddz097 Nunes, Catarina; Mestre, Isa; Marcelo, Adriana; Koppenol, Rebekah; Matos, Carlos A; Nóbrega, Clévio. "MSGP: the first database of the protein components of the mammalian stress granules". Database 2019 (2019): http://dx.doi.org/10.1093/database/baz031. 10.1093/database/baz031 Matos, Carlos A.; de Almeida, Luís Pereira; Nóbrega, Clévio. "Machado-Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy". Journal of Neurochemistry 148 1 (2018): 8-28. http://dx.doi.org/10.1111/jnc.14541. 10.1111/jnc.14541 Marcelo, Adriana; Brito, Filipa; Carmo-Silva, Sara; Matos, Carlos A; Alves-Cruzeiro, João; Vasconcelos-Ferreira, Ana; Koppenol, Rebekah; et al. "Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models". Human Molecular Genetics 28 1 (2018): 51-63. http://dx.doi.org/10.1093/hmg/ddy328. 10.1093/hmg/ddy328 Matos, C.A.; de Almeida, L.P.; Nóbrega, C.. "Proteolytic cleavage of polyglutamine disease-causing proteins: Revisiting the toxic fragment hypothesis". Current Pharmaceutical Design 23 5 (2017): 753-775. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017122161&partnerID=MN8TOARS. 10.2174/1381612822666161227121912 Matos CA; Nóbrega C; Louros SR; Almeida B; Ferreiro E; Valero J; Pereira de Almeida L; Macedo-Ribeiro S; Carvalho AL. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.". Journal of Cell Biology (2016): http://europepmc.org/abstract/med/26880203. 10.1083/jcb.201506025 Almeida B; Abreu IA; Matos CA; Fraga JS; Fernandes S; Macedo MG; Gutiérrez-Gallego R; et al. "SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.". Biochimica et Biophysica Acta - Molecular Basis of Disease (2015): http://europepmc.org/abstract/med/26073430. 10.1016/j.bbadis.2015.06.010 Matos CA; de Macedo-Ribeiro S; Carvalho AL. "Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.". Progress in Neurobiology (2011): http://europepmc.org/abstract/med/21740957. 10.1016/j.pneurobio.2011.06.007
Online resource	Estevam, Bernardo; Matos, Carlos A; Nóbrega, Clévio David Rodrigues. A Database for Polyglutamine Diseases. 2023. https://polyq.pt. Clévio Nóbrega; Catarina Nunes; Isa Mestre; Adriana Marcelo; Rebekah Koppenol; Matos, Carlos A. MSGP Database - Mammalian Stress Granules Proteome. 2018. https://msgp.pt.
Preprint	Lopes, Sara Monteiro; Lopes, Miguel Monteiro; Oliveira, Daniela; Santana, Magda Matos; Fernandes, Ana Rita; Vasconcelos-Ferreira, Ana; Pereira, Dina; et al. "Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity". 2025. https://doi.org/10.1101/2025.02.14.637261. 10.1101/2025.02.14.637261
Thesis / Dissertation	"Antibiotherapy of infections caused by multidrug-resistant Gram-positive cocci". Master, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2023. Matos, Carlos A. "Regulation of ataxin-3 by phosphorylation: Relevance for Machado-Joseph disease.". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2015. Matos, Carlos A. "Post-translational modifications of ataxin-3, the protein involved in Machado-Joseph disease: evidences for phosphorylation and sumoylation.". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.

Artistic / Performance

Theatre play

2016. Luz-Livro.
2016. O Ponto Que Nos Une.
2015. Atos de Laboratório.
2015. Luz de Perdição.

Intellectual property

Patent

Matos, Carlos; Sara Lopes; Nobre, Rui; Luis Pereira de Almeida. 2025. "CRISPR-CAS9 BASED TOOLS: POTENTIAL NOVEL THERAPEUTIC APPROACHES FOR MACHADO- JOSEPH DISEASE".
Granted/Issued

Other

Dataset

Matos, Carlos A. NeuroMorpho.Org. http://neuromorpho.org/about.jsp.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2026/02/06	Establishment of a scalable neuronal reporter model of Machado-Joseph disease based on gene-edited patient cells as a platform for high-throughput drug repurposing.	LVI Reunião da Sociedade Portuguesa de Farmacologia (SPF) Sociedade Portuguesa de Farmacologia (SPF) (Coimbra, Portugal)
2025/11/19	Terapia génica: conceitos básicos, estado atual e perspetivas futuras.	Seminar to Eukaryotic Molecular Biology students of the Molecular and Microbial Biology MSc Universidade do Algarve, Faculdade de Ciências e Tecnologia (Faro, Portugal)
2025/11/17	Terapia génica: fundamentos, promessas e desafios	Terapia génica: fundamentos, promessas e desafios. Seminário na UC de Tópicos em Biologia Aplicada, ministrado aos alunos da Licenciatura em Biologia Universidade do Algarve, Faculdade de Ciências e Tecnologia (Faro, Portugal)
2025/11/13	Terapia génica in vivo e terapias combinadas.	Pós-graduação Terapias Avançadas Baseadas em Genes e Células Ordem dos Farmacêuticos (Portugal)
2025/11	Compreender para tratar: o papel da investigação científica no estudo e na terapia das doenças raras.	Mesa Redonda sobre a Síndrome de Sotos Grupo de Trabalho da Doença de Sotos e pela SERaro – Associação das Síndromes Excecionalmente Raras de Portugal
2025/11	Evolução dos Métodos Laboratoriais para o Diagnóstico da Síndrome Antifosfolipídica.	4º Congresso Internacional de História da Ciência no Ensino Universidade Federal de Uberlãndia (Brazil)
2025/11	Anticoagulantes Orais Diretos: Contexto Histórico e Impacto na Prática Clínica Atual.	4º Congresso Internacional de História da Ciência no Ensino Universidade Federal de Uberlândia (Brazil)
2025/11	Factor V Leiden and Pregnancy Loss: A Clinical Case Report.	29th International Congress of Thrombosis (ICT) European and Mediterranean League Against Thrombotic Diseases (Porto, Portugal)
2025/10/18	Editing genes and beyond: the CRISPR system at the edge of biotechnology and biomedicine.	Seminar to Recombinant DNA Technology students of the Pharmaceutical Biotechnology MSc Universidade de Coimbra, Faculdade de Farmácia (Coimbra, Portugal)
2025/10	Abordagem integrada no diagnóstico da sindrome antifosfolipídica: a importância laboratorial para a deteção de anticorpos antifosfolipídicos.	Congresso 40 anos da Associação Portuguesa de Técnicos de Análises clínicas (APTAC) Associação Portuguesa de Técnicos de Análises clínicas (APTAC) (Lisbon, Portugal)
2025/09/26	Terapia génica e edição de genes.	Seminar to Molecular Biology and Genetics students from the Biomedical Sciences MSc Universidade dos Açores, Faculdade de Ciências e Tecnologia (Ponta Delgada, Portugal)
2025/09	Investigação pré-clínica na ataxia espinocerebelosa tipo 2: desenvolvimento de um novo modelo animal e testagem de novas terapias.	O Futuro das Ataxias Associação Portuguesa de Ataxias Hereditárias (APAHE) e Associação Atlântica de Apoio aos Doentes de Machado-Joseph (AAADMJ) (Portugal)
2025/07	Modelos Animais em Investigação Biomédica: Uma Estratégia Pedagógica para o Desenvolvimento de Competências Científicas	11º Congresso Nacional de Práticas Pedagógicas no Ensino Superior Universidade de Évora (Évora, Portugal)
2025/05/20	Vírus que curam: revertendo o envelhecimento acelerado na síndrome de Cockayne.	Talk directed at the general public Pint of Science initiative (Faro, Portugal)
2025/05/13	Farmacogenética.	Seminar to Genetics II students of the Bachelor in Medicine (Basic Cycle) Universidade dos Açores, Faculdade de Ciências e Tecnologia (Ponta Delgada, Portugal)
2025/05	ATXN2 mRNA shuttling to exosomes: a mechanism underlying pathogenesis?	CAG Triplet Repeat Disorders Gordon Research Conference Gordon Research Conferences (Lucca, Italy)
2025/05	CRISPR interference-mediated silencing of ATXN2 to mitigate pathological features in spinocerebellar ataxia type 2 patient-derived neurons.	CAG Triplet Repeat Disorders Gordon Research Conference Gordon Research Conferences (Lucca, Italy)
2025/03/06	Doenças Raras.	Seminar to Senior University Students Universidade Senior de Loulé (Loulé, Portugal)
2025/02/05	Gene therapy: present state and future perspectives	Seminar to high school students Nobel Algarve British International School (Lagoa, Portugal)
2024/12/02	Terapia génica: lições passadas e perspetivas futuras.	1º Congresso Científico do Núcleo de Estudantes de Ciências Farmacêuticas da Universidade do Algarve (NECiFarm) Núcleo de Estudantes de Ciências Farmacêuticas da Universidade do Algarve (NECiFarm) (faro, Portugal)
2024/11/26	Terapia génica: fundamentos, promessas e desafios.	Seminar to Topic in Applied Biology students of the Biology BSc Universidade do Algarve, Faculdade de Ciências e Tecnologia (Faro, Portugal)
2024/11/22	Terapia génica: fundamentos e promessas	Seminar to Eukaryotic Molecular Biology students of the Molecular and Microbial Biology MSc Universidade do Algarve, Faculdade de Ciências e Tecnolgia (Faro, Portugal)
2024/11/14	Terapia génica in vivo.	Pós-graduação Terapias Avançadas Baseadas em Genes e Células Ordem dos Farmacêuticos (Portugal)
2024/11/14	Terapias combinadas.	Pós-graduação Terapias Avançadas Baseadas em Genes e Células Ordem dos Farmacêuticos (Portugal)
2024/11	A novel transgenic mouse model of spinocerebellar ataxia type 2 bearing 129 CAG repeats: neuropathologic and phenotypic characterization.	International Congress for Ataxia Research (ICAR) Ataxia UK, National Ataxia Foundation (NAF), Friedreich's Ataxia Research Alliance (FARA) and Ataxia Global Initiative (AGI) (London, United Kingdom)
2024/11	CRISPR-Cas9-mediated ATXN3 gene inactivation as a potential therapeutic approach for Machado-Joseph disease.	International Congress for Ataxia Research (ICAR) Ataxia UK, National Ataxia Foundation (NAF), Friedreich's Ataxia Research Alliance (FARA) and Ataxia Global Initiative (AGI) (London, United Kingdom)
2024/11	Nano narratives: unraveling spinocerebellar ataxia type 2 pathogenesis through exosomes.	International Congress for Ataxia Research (ICAR) Ataxia UK, National Ataxia Foundation (NAF), Friedreich's Ataxia Research Alliance (FARA) and Ataxia Global Initiative (AGI) (London, United Kingdom)
2024/09/28	Terapia génica e edição de genes.	Seminar to Molecular Biology and Genetics students from the Biomedical Sciences MSc Universidade dos Açores, Faculdade de Ciências e Tecnologia (Ponta Delgada, Portugal)
2024/09	Pre-clinical research on spinocerebellar ataxia type 2: from disease modelling to new therapeutic perspectives.	19º Congresso da Sociedade Portuguesa de Neurorradiologia Diagnóstica e Terapêutica (SPNR) Sociedade Portuguesa de Neurorradiologia Diagnóstica e Terapêutica (SPNR) (Portugal)
2024/09	Understanding spinocerebellar ataxia type 2 disease progression through small extracellular vesicles	4th Harvard European Alumni Training Network (HEAT-Net) Meeting “Frontiers in Neurodegeneration from Bench to Bedside” Harvard European Alumni Training Network (HEAT-Net) (Cadiz, Spain)
2024/05/21	A doença de Machado-Joseph e outras ataxias hereditárias causadas por repetições de nucleótidos.	Seminar to Molecular Genetics students of the Biomedical Sciences BSc Universidade do Algarve, Faculdade de Medicina e Ciências Biomédicas (Faro, Portugal)
2024/04/17	Terapia génica in vivo e terapias combinadas.	Pós-graduação Terapias Avançadas Baseadas em Genes e Células Ordem dos Farmacêuticos (Portugal)
2024/01/16	Gene therapy - promisses and challenges	Universidade Sénior de Loulé Universidade Sénior de Loulé (Loulé, Portugal)
2024/01/16	Terapia génica – promessas e desafios.	Seminar to Senior University Students Universidade Sénior de Loulé (Loulé, Portugal)
2024	Generation of a CSB-iPSC disease model as a platform to develop gene therapy approaches for Cockayne Syndrome type B	LIV Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2023/11/09	Gene Editing: From reality to fiction	"Geneticamente falando" seminar cycle Sociedade Portuguesa de Genética (SPG) (Portugal)
2023/11/08	Esclerose Múltipla	Seminar to Senior University Students Universidade Sénior de Loulé (Loulé, Portugal)
2023/10/31	Gene Editing - Biological principles and technical bases	ESN-ISN Neurochemistry School 2023 Algarve Biomedical Center Research Institute (ABCRI) (Faro, Portugal)
2023/09/05	Gene and Cell Therapy: History and innovation in the teaching of Biomedical Sciences at the University of Algarve	3rd International Congress of History of Science in Teaching Universidade do Algarve (Faro, Portugal)
2023/09	Terapia Génica e Celular: história e inovação no ensino das Ciências Biomédicas na Universidade do Algarve.	3º Congresso Internacional de História da Ciência no Ensino Universidade do Algarve
2023/07/11	Multiple sclerosis	Universidade Sénior de Loulé Universidade Sénior de Loulé (Loulé, Portugal)
2023	Characterization of a new transgenic mouse model for spinocerebellar ataxia type 2 with 129 glutamine repeats: unraveling neuropathologic and motor phenotype.	I FloripaNeuro Universidade Federal de Santa Catarina (Florianópolis, Brazil)
2023	Novel approaches to the treatment of rare neurodegenerative diseases: development and pre-clinical testing of gene therapies.	44th European Pharmaceutical Students' Associations (EPSA) Annual Congress European Pharmaceutical Students' Associations (EPSA) (Podcetrtek, Slovenia)
2023	Gene Editing - A new hope for untreatable diseases.	44th European Pharmaceutical Students' Associations (EPSA) Annual Congress European Pharmaceutical Students' Associations (EPSA) (Podcetrtek, Slovenia)
2023	Invited speech at the “From the reconfiguration of the organic: genomic editing” session of the Public Session of the Portuguese National Ethics Council for the Life Sciences	Public Session of the Portuguese National Ethics Council for the Life Sciences Portuguese National Ethics Council for the Life Sciences (Faro, Portugal)
2023	Gene Therapy - promises and challenges	Topics in Biology Applied seminar University of Algarve (Faro, Portugal)
2023	Is it possible to use viruses to treat diseases?	Seminar to middle school students Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2023	Edição de genes – da ficção à realidade.	Seminário Geneticamente Falando Sociedade Portuguesa de Genética (SPG) (Portugal)
2022/03/03	Será possível usar vírus para tratar doenças? (Is it possible to use virus to treat diseases?)	Seminar to middle school students Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022	Are the neuropathological features associated with mutant Ataxin-2 expression exacerbated by aging?	Aging Without Borders Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (Faro, Portugal)
2022	Ataxia espinocerebelosa tipo 2: caracterização de um novo modelo transgénico de murganho com fenótipo neuropatológico e motor. (Spinocerebellar ataxia type 2: characterization of a novel transgenic mouse model with a neuropathological and motor phenotype)	Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms Meeting of the Portuguese Society of Movement Disorders (SPDMov) (Luso, Portugal)
2022	Upregulation of autophagy as a therapeutic strategy for spinocerebellar ataxia type 2.	XLXII Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022	The stress granule protein G3BP1 reverts pathological defects in two diferent polyglutamine diseases.	XLXII Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022	ATXN2 knockdown through CRISPR-Cas-based strategies: a therapeutic approach for spinocerebellar ataxia type 2?	XLXII Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2022	Hereditary ataxias caused by repeat expansion mutations: The special case of Machado-Joseph disease	Expression and Pathology seminar lectured to the students of the MSc degree in Molecular and Microbial Biology Universidade do Algarve Faculdade de Ciências e Tecnologia (Faro, Portugal)
2022	Gene Therapy - promises and challenges	Topics in Applied Biology seminar University of Algarve (Faro, Portugal)
2022	Is it possible to use viruses to treat diseases?	Seminar to middle school students Escola E.B. 2,3 Dr. Garcia Domingues (Silves, Portugal)
2022	The brain and time	XII National Journey of Biomedical Sciences 2022 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas (Faro, Portugal)
2021/10/08	Terapia génica: da promessa à realidade (Gene therapy: from promise to reality)	IV Jornadas Algarve Biomedical Center Algarve Biomedical Center (Moura, Portugal)
2021/05/28	CRISPR-based therapies - from fiction to fact	The CRISPR Revolution: a workshop in gene editing, from cells to animal models University of Algarve (Faro, Portugal)
2021/05/24	Gene Editing - Biological principals and technical bases	The CRISPR Revolution: a workshop in gene editing, from cells to animal models University of Algarve (Faro, Portugal)
2021/05/24	The CRISPR toolbox	The CRISPR Revolution: a workshop in gene editing, from cells to animal models University of Algarve (Faro, Portugal)
2021	RBP-X protein mitigates disease traits in different mice models of polyglutamine diseases	XLXI Meeting Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021	The CRISPR system – Biologic bases, technical perspectives and applications	Experimental Techniques seminar University of Algarve (Faro, Portugal)
2021	Mapping the domains of RBP-X towards mitigation of the pathological phenotype in polyglutamine disease models	XLXI Meeting Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021	CRISPR/Cas9-mediated silencing of ATXN2 expression	XLXI Meeting Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021	Autophagy dysfunction in spinocerebellar ataxia type 2 models and a potential therapeutic strategy	XLXI Meeting Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2021	Mutant ataxin-2 pathological features is altered by the aging process	25th Annual Meeting of the Portuguese Society of Human Genetics (SPGH) Portuguese Society of Human Genetics (SPGH) (Porto, Portugal)
2021	The RNA-binding Protein X Mitigates Common Age-associated Features in Progerin-expressing Cells	IV Jornadas Algarve Biomedical Center Algarve Biomedical Center (Moura, Portugal)
2021	Gene Therapy - promises and challenges	Topics in Applied Biology seminar University of Algarve (Faro, Portugal)
2021	CRISPR-mediated gene silencing in the treatment of Machado-Joseph disease	Eukaryotic Molecular Genetics seminar University of Algarve (Faro, Portugal)
2021	When RNA-binding proteins meet the Hutchinson-Gilford Progeria syndrome: a gene delivery approach to mitigate premature aging.	International Health Sciences Conference 2021 (Kaunas, Lithuania)
2020	CRISPR-mediated silencing of mutant ataxin-3 ameliorates motor symptoms of a Machado-Joseph disease model in vivo.	XLX Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020	Stress granules crosstalk with autophagy in a context of polyglutamine diseases.	XLX Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020	RNA-binding proteins as potential therapeutic targets for polyglutamine diseases.	XLX Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2020	Gene Therapy – promises and challenges	Topics in Applied Biology seminar University of Algarve (Faro, Portugal)
2020	Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease	24th Annual Meeting Portuguese Society for Human Genetics (SPGH) (Lisbon, Portugal)
2020	Stress granules dynamics in polyglutamine diseases	International Meeting of the Portuguese Society of Genetics Portuguese Society of Genetics (Faro, Portugal)
2019	CRISPR-Cas9 systems targeting ATXN3 as therapeutic approaches for Machado-Joseph Disease	2019 International Machado-Joseph Research Disease Conference The Israeli Machado - Joseph (MJD) Association (Washington, United States)
2019	CYP46A1-gene therapy improves Machado-Joseph disease in mouse models.	23rd Annual Meeting of the Portuguese Society of Human Genetics (SPGH) Portuguese Society of Human Genetics (SPGH) (Coimbra, Portugal)
2019	Permanent inactivation of the ATXN3 gene: a possible therapeutic approach for Machado-Joseph disease.	XVI Meeting of the Portuguese Society for Neuroscience (SPN) Portuguese Society for Neuroscience (SPN) (Lisbon, Portugal)
2019	CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model.	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) European Society for Clinical Investigation (ESCI) (Coimbra, Portugal)
2019	CRISPR as a tool for Machado-Joseph disease therapy.	Distinguished Seminars, Center for Biomedical Research – CBMR Center for Biomedical Research – CBMR, University of Algarve (Faro, Portugal)
2019	CRISPR as a tool for Machado-Joseph disease therapy.	Seminar session University of Algarve (Faro, Portugal)
2019	Gene correction and disease models.	Pharmaceutical Biotechnology class University of Coimbra (Coimbra, Portugal)
2019	Cell cultures in neurodegenerative diseases investigation	Animal Cell Culture Technology seminar University of Algarve (Faro, Portugal)
2019	Ataxin-3 phosphorylation as a neuroprotective mechanism in the context of Machado-Joseph disease	Neurobiology seminar University of Algarve (Faro, Portugal)
2019	Development and characterization of a lentiviral mouse model for spinocerebellar ataxia type 2	3rd Meeting Algarve Biomedical Center (Albufeira, Portugal)
2018	CRISPR-Cas9-mediated pre- transcriptional silencing of mutant ataxin-3.	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF) Sociedade Portuguesa de Farmacologia (SPF) (Lisbon, Portugal)
2018	Tailoring gene editing strategies for the treatment of Machado-Joseph disease.	Portuguese Society of Movement Disorders (SPDMov) Congress Portuguese Society of Movement Disorders (SPDMov) (Curia, Portugal)
2018	Ibuprofen decreases neuroinflammation and improves neuropathology and motor impairments in Machado-Joseph disease.	XLVIII Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Lisbon, Portugal)
2018	Gene editing in the treatment of neurodegenerative diseases.	Meet.Lab Coimbra Symposium Núcleo de Estudantes de Biologia da Associação Académica da Universidade de Coimbra (NEBAAC) (Coimbra, Portugal)
2018	CRISPR-Cas9 in MJD treatment and disease model generation	MIT Portugal Doctoral Programme in Bioengineering Systems class Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2018	Gene editing strategies in gene therapy	Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) class Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2018	Genome Editing: nuclease-based approaches	Molecular Cell Biology class University of Coimbra (Coimbra, Portugal)
2018	CYP46A1-gene therapy alleviates spinocerebellar ataxia in mouse models	Congress European Society of Gene and Cell Therapy (ESGCT) (Lausanne, Switzerland)
2017	TALEN and CRISPR gene-editing for treatment of Machado-Joseph disease.	2nd International Ataxia Research Conference (IARC) FARA, Ataxia UK, fara Australia and Gofar (Pisa, Italy)
2017	Pre-transcriptional silencing of ataxin-3 using a CRISPR-Cas9-derived system.	Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017	Gene editing strategies for Machado-Joseph disease.	XLVII Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017	Ibuprofen reduces neuroinflammation and neuropathology in Machado-Joseph disease.	XLVII Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Coimbra, Portugal)
2017	CRISPR-Cas9 as a tool for Disease Model Generation	MIT Portugal Doctoral Programme in Bioengineering Systems class Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016	Phosphorylation of ataxin-3 decreases neuronal defects in Machado-Joseph disease models.	XLVI Meeting of the Portuguese Society of Pharmacology (SPF) Portuguese Society of Pharmacology (SPF) (Porto, Portugal)
2016	Modulating polyglutamine toxicity through phosphorylation: the example of ataxin-3, the protein involved in Machado-Joseph disease.	CNC.IBILI Seminar CNC.IBILI (Coimbra, Portugal)
2016	Modulating polyglutamine toxicity through phosphorylation: the example of ataxin-3, the protein involved in Machado-Joseph disease	Seminar Center for Neuroscience and Cell Biology
2016	Nuclease-based genome editing technologies	Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2016	Gene Editing – Molecular bases, technical perspectives and applications	Gene Therapy seminar University of Algarve (Faro, Portugal)
2014	Protein phosphorylation as a toxicity modulator in Machado-Joseph disease.	XVIII Congress of the Portuguese Biochemical Society (SPB) Portuguese Biochemical Society (SPB) (Coimbra, Portugal)
2014	Protein phosphorylation as a modulator in Machado-Joseph disease.	5th Anniversary of the Department of Life Sciences Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra (Coimbra, Portugal)
2013	Ataxin-3 phosphorylation: effects on polyglutamine toxicity mechanisms involved in Machado-Joseph disease.	XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting CNC.IBILI (Coimbra, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2026 - Current	Safety in Gene Therapy: Ethical Challenges in Advanced Therapeutic Products Development and Approval. Supervisor of Tuyanne Vitória Pires da Silva	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2026 - Current	A Terapia Génica na Doença de Alzheimer: Abordagens Baseadas em Edição Génica Supervisor of Rodrigo António Marramaque Bruno	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2026 - Current	Rigidez temporal na Perturbação Obsessivo-Compulsiva: uma perspetiva cronobiológica e neurobiológica. Supervisor of Miguel Lamúria Barradas	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2026 - Current	Caracterização fenotípica de um modelo animal da síndrome de Cockayne tipo B Supervisor of Laura Simões Mendes	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2026 - Current	Perspetivas emergentes sobre a utilização de psicadélicos na terapia farmacológica da depressão: efeitos neuroquímicos e modulação da plasticidade sináptica. Supervisor of Fábio Miguel Pereira Viegas	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2026 - Current	Eixo Rim-Cérebro nas Doenças Neurodegenerativas: Impacto da Depuração Renal na Progressão Patológica. Supervisor of Dalma Indeque Hamelberg	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - Current	Targeting neuronal transmembrane transport in spinocerebellar ataxia type 3: from pathogenesis to therapeutics. Supervisor of Adriana Afonso Vaz	Ciências Biomédicas (PhD) (PhD) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2025 - Current	Anticoagulantes orais directos como alternativa a anticoagulantes antagonistas da vitamina K na profilaxia de síndrome antifosfolipídico de baixo risco. Co-supervisor of Raquel Ferreira Serra Fernandes Patrão	Ciências Biomédicas (PhD) (PhD) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2024 - Current	Development of CRISPR-based systems for the non-invasive treatment of SCA2. Co-supervisor of Cristiana Raquel Rodrigues Madeira	Ciências Biomédicas (PhD) Universidade do Algarve, Portugal
2024 - Current	Terapias Avançadas no Tratamento da Doença Aterosclerótica: Novas Perspectivas em Biotecnologia e Farmacologia Supervisor of Marília Ferreira Lopes	Ciências Farmacêuticas (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022/09/01 - Current	Disease spreading in spinocerebellar ataxia type 2: from pathogenic mechanisms to targeted therapeutics Co-supervisor of Rafael Gomes Costa	Ciências Biomédicas (PhD) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2025 - 2025	Caracterização da Interação entre o Recetor EphA4 e os Recetores de Glutamato: Bases Moleculares para Futuras Aplicações na Doença de Alzheimer. Co-supervisor of July Cleva Hans da Silva Alves	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - 2025	O Impacto das Células CAR-T na Terapia Génica do Cancro. Supervisor of Inês Amado Lemos Correia	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - 2025	Other Genders, Other Experiences: Unmasking Gender Bias in Degenerative Disease Diagnosis and Care. Supervisor of Celina Vassilissa Plachinskaya Mont-Rond Rodrigues	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - 2025	Edição de genomas e terapia génica: investigação clínica de estratégias terapêuticas baseadas no sistema CRISPR-Cas. Supervisor of Carolina Casanova Moreira	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - 2025	From Pluripotency to Neurons: Inducing Neural Differentiation in iPSCs of patients’ cell lines. Co-supervisor of Beatriz Margarido Sousa Carvalho	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - 2025	Síndrome de Guillain-Barré em Crianças e Adolescentes: Fatores Desencadeantes e Fisiopatologia Supervisor of Beatriz Graça Landeiro	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2024 - 2025	Out of Shape: How Pharmaceutical Research Fails to Fit Women’s Needs – A Reflection on the Causes and Consequences of a Male-Centric Drug Research and Development Process Supervisor of Celina Vassilissa Plachinskaia Mont-Rond Rodrigues	Ciências Farmacêuticas (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2024 - 2025	Abordagens Terapêuticas na Doença de Parkinson: Intervenção do Farmacêutico Supervisor of Jéssica Sofia Rodrigues Baião	Ciências Farmacêuticas (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2020 - 2025	Investigating the impact of stress granules in the pathogenesis of spinocerebellar ataxia type 2 Co-supervisor of André Filipe Vieira Conceição	Ciências Biomédicas (PhD) Universidade do Algarve, Portugal
2024 - 2024	Perturbação de hiperatividade com défice de atenção (PHDA): uma revisão atual e perspetivas sobre o futuro do tratamento farmacológico Supervisor of Hugo Nascimento Santos	Ciências Farmacêuticas (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2024 - 2024	Nanocorpos como potenciais agentes terapêuticos para doenças neurodegenerativas. Supervisor of Tiago Alexandre Vitoriano Amendoeira	Ciências Biomédicas (Degree) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2023 - 2024	Mechanisms of intercellular dissemination of ataxin-2 mRNA: impact of RNA-binding proteins and extracellular vesicles Supervisor of Isabelli Mendes Hombri	Biology (Degree) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - 2024	Evaluation of the expression of human ERCC6 protein in mice upon AAV-mediated delivery Supervisor of Carolina Martinheira	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2024	Molecular tools to study SCA2: from new advanced disease models to CRISPR-mediated editing approaches Co-supervisor of Rebekah Koppenol	Ciências Biomédicas (PhD) Universidade do Algarve, Portugal
2022 - 2023	Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells Supervisor of Cristiana Raquel Rodrigues Madeira	Ciências Biomédicas - Mecanismos de Doenças (Master) Universidade do Algarve, Portugal
2021 - 2022/11/28	PolyQ Database - A polyglutamine disease database Co-supervisor of Bernardo Alexandre Encarnação Estevam	Ciências Biomédicas - Mecanismos de Doença (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022	Evaluation of the levels of aneuploidy in fibroblasts from an individual with spinocerebellar ataxia type 3 caused by polyglutamine expansion Supervisor of Júlia Pereira Gonçalves	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022	Assessing the neuropathologic profile and the motor phenotype of a novel spinocerebellar ataxia type 2 mouse model with severe human ATXN2 expression Supervisor of João Paulo Viegas Amaro	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022	Development of ATXN2 gene silencing strategies based on the CRISPR-Cas gene editing system Supervisor of Erica Goufa Coelho	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2022	Assessing the motor phenotype and the neuropathologic profile of a novel spinocerebellar ataxia type 2 mouse model with moderate human ATXN2 expression Supervisor of Andreia Sofia de Sá Barreira Cordeiro	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021/11/26	Insights into the spreading of ataxin-2 through extracellular vesicles Co-supervisor of Rafael Gomes Costa	Ciências Biomédicas - Mecanismos de Doença (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021	Silencing of the mutant form of the ATXN2 gene as a putative therapeutic strategy for spinocdrebllar ataxia type 2 Supervisor of Catarina Barbosa	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020 - 2021	Assessing CRISPR/Cas9-mediated insertion of an indel mutation in the ATXN2 gene Supervisor of Raquel Costa	Ciências Biomédicas (Degree) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2019 - 2020	Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon Supervisor of Ricardo Reis	Ciências Biomédicas (Master) Universidade do Algarve, Portugal
2019 - 2020	A comparative study on the function and activity of ZEB transcription factors in glioblastoma. Co-supervisor of Nuno Ramalho	Ciências Biomédicas (Master) Universidade do Algarve, Portugal
2019 - 2019	Modelling cholesterol metabolism in the hypothalamus and its impact on white adipose tissue Co-supervisor of Joana Filipa Rolo	Ciências Biomédicas (Degree) Universidade do Algarve, Portugal
2018 - 2019	CRISPR-Cas9 as a tool for gene therapy in Machado-Joseph disease: silencing ATXN3 and CAG expansion correction Supervisor of André Filipe Vieira da Conceição	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2019	Insights into the role of GXXXX on Polyglutamine diseases Co-supervisor of Diogo Teixeira	Biologia Molecular e Microbiana (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018	CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease Supervisor of Frederico Mendes e Pena	Bioquímica (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016	Development of a cellular model for Amyotrophic Lateral Sclerosis (ALS) Supervisor of Rebekah Koppenol	Ciências Biomédicas (Degree) Universidade do Algarve, Portugal
2012 - 2012	Role of atx-3 aggregation and phosphorylation in the pathogenesis of MJD Supervisor of Marilisa Vigorita	Pharmacologic Basis of Therapy (Master) Università degli Studi del Sannio, Italy

Event organisation

	Event name Type of event (Role)	Institution / Organization
2026/10 - Current	ISN Advanced School – 2026 Edition (2026/10) Other (Member of the Organising Committee)	Algarve Biomedical Center Research Institute, Portugal Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/12/16 - 2025/12/17	Jornada Anual dos Doutorandos do Programa Doutoral em Ciências Biomédicas 2025 (2025/12/16 - 2025/12/17) Meeting (Co-organisor)	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2024/12/16 - 2024/12/17	Jornada Anual dos Doutorandos do Programa Doutoral em Ciências Biomédicas 2024 (2024/12/16 - 2024/12/17) Meeting (Co-organisor)	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2024/09/26 - 2024/09/28	19º Congresso Nacional da Sociedade Portuguesa de Neurorradiologia Diagnóstica e Terapêutica (SPNR) (2024/09/26 - 2024/09/28) Congress (Member of the Organising Committee)	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023/12/19 - 2023/12/20	Jornada Anual dos Doutorandos do Programa Doutoral em Ciências Biomédicas 2023 (2023/12/19 - 2023/12/20) Meeting (Co-organisor)	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2023/10/29 - 2023/11/04	ESN-ISN Neurochemistry School 2023 (2023/10/29 - 2023/11/04) Other (Co-organisor)	Algarve Biomedical Center Research Institute, Portugal
2023/05/05 - 2023/05/05	"Advances in Polyglutamine diseases research", a scientific symposium of FENS Regional Meeting 2023 - Algarve. Albufeira, Portugal. (2023/05/05 - 2023/05/05) Symposium (Co-organisor)	Algarve Biomedical Center Research Institute, Portugal
2023 - 2023	3rd International Congress of History of Science in Teaching (3.º Congresso Internacional de História da Ciência no Ensino) (2023/09/04 - 2023/09/06) Congress (Member of the Organising Committee)	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2022 - 2023	FENS Regional Meeting 2023 (2022 - 2023) Meeting (Member of the Organising Committee)	Universidade do Algarve, Portugal
2022 - 2022	Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) (2022 - 2022) Meeting (Member of the Organising Committee)	Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal Algarve Biomedical Center Research Institute, Portugal
2022 - 2022	ABC Days - V National Meeting of the Algarve Biomedical Center. Sagres, Portugal. (2022 - 2022) Meeting (Member of the Organising Committee)	Algarve Biomedical Center, Portugal
2021 - 2022	Fala-me NEURO (Talk NEURO to me) science communication initiative (2021 - 2022) Other (Co-organisor)	Sociedade Portuguesa de Neurociências, Portugal
2021/05/24 - 2021/05/28	The CRISPR Revolution: a workshop on gene editing, from cells to animal models (2021/05/24 - 2021/05/28) Workshop (Co-organisor)	Universidade do Algarve, Portugal
2018 - 2018	"Overcoming Challenges in Scientific Careers ", a symposium on career development for PhD students and PhD holders (2018 - 2018) Symposium (Member of the Organising Committee)	CNC.IBILI, Portugal
2018 - 2018	“Me in the spotlight: self-presentation for networking and career development”, a workshop on career development for PhD students and PhD holders (2018 - 2018) Workshop (Member of the Organising Committee)	CNC.IBILI, Portugal
2018 - 2018	“Finishing the PhD: how to turn anxiety into an actionable plan?”, a workshop on career development for PhD students and PhD holders (2018 - 2018) Workshop (Member of the Organising Committee)	CNC.IBILI, Portugal

Event participation

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2026/02/14	Profilaxia pré-exposição (PREP) no VIH: perspectivas atuais e futuras em Portugal. (Thesis) Main arguer	Aloizo Bueno de Oliveira Filho (Master) Universidade dos Açores Faculdade de Ciências e Tecnologia, Portugal
2026/01/12	On The Modulation Of Adult Brain Plasticity A Strategy To Improve Human Neuroepithelial Stem Cells Migration, Differentiation, And Functional Integration Upon Cerebellar Transplantation In Machado-Joseph Disease. (Thesis) Arguer	Daniel Alexandre Sousa Henriques (PhD) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2025/12/17	Out of Shape: How Pharmaceutical Research Fails to Fit Women’s Needs – A Reflection on the Causes and Consequences of a Male-Centric Drug Research and Development Process. Supervisor	Celina Vassilissa Plachinskaia Mont-Rond Rodrigues (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2025/11/18	Perturbação de hiperatividade com défice de atenção (PHDA): uma revisão atual e perspetivas sobre o futuro do tratamento farmacológico. Supervisor	Hugo Nascimento Santos (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2025/11/12	O papel da hormona materna da tiróide (MT3) no neurodesenvolvimento de vertebrados. (Thesis) Main arguer	Bárbara Normano Teixeira Fernandes Teixeira Ferreira (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2025/11/11	Abordagens Terapêuticas na Doença de Parkinson: Intervenção do Farmacêutico. Supervisor	Jéssica Sofia Rodrigues Baião (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2025/11/04	Análise Bioinformática da Via Hedgehog em Cancros Humanos: Expressão, Metilação e Impacto Prognóstico no KIRC e LGG. (Thesis) Main arguer	Diogo Gonçalo Ribeiro Paulo e Soares Aguiar (Master) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/10/28	Farmacoterapia da Insuficiência Cardíaca. (Thesis) Main arguer	Beatriz Martins Gonçalves Piteira Fragoso (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2025/10/20	Terapias Hormonais de Afirmação de Género. (Thesis) Main arguer	Mafalda Mourinho Prata (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2025/07/22	Vasculites associadas aos ANCA. (Thesis) Main arguer	Tomás Graça Domingos (Other) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/07/22	AVC na gravidez. (Thesis) Main arguer	Íris Oliveira Jorge (Other) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/07/22	Molecular mechanisms underlying therapeutic effects of NMDAR/TRPM4 interface inhibitors in spinocerebellar ataxias (Thesis) Main arguer	Alice Rodrigues do Vale (Other) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/07/10	Trombofilia Hereditária e Gravidez. (Thesis) Main arguer	Leonor Gonçalves da Luz (Other) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/04/14	Mitochondrial Gene Therapy: Development of a mitochondrial targeted peptide/plasmid DNA vector (Thesis) Main arguer	Rúben Miguel Ribeiro Faria (PhD) Instituto Universitário da Beira Interior, Portugal
2024/11/07	A Doença Celíaca e as suas comorbilidades autoimunes: Uma revisão das suas relações clínicas e estratégias terapêuticas (Thesis) Main arguer	Andreia Filipa Gouveia Bernardo (PhD) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2024/10/25	Fisiopatologia e Farmacoterapia do Melanoma (Thesis) Main arguer	Carolina Maciel Correia (Master) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2024	Terapias Celulares para Degeneração da Retina: Uma Visão do Futuro. (Thesis) Main arguer	Mariana Bairreiro Mira Monteiro (Other) Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2023/12/15	Generation of a novel Cockayne syndrome B neuronal culture model from patient-derived induced pluripotent stem cells Supervisor	Cristiana Raquel Rodrigues Madeira (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/12/05	Modelling aging in vitro using stem cells-derived cells (Thesis) Main arguer	Pedro Miguel Canada de Sousa (Master) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022/07/27	A robust study on the Ataxin-3 fibrillization pathway for the discovery of new inhibitory compounds	Francisco Rosário de Figueiredo (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/04/22	Establishing the relevance of Tau isoform imbalance in the onset and progression of Machado Joseph disease (Thesis) Main arguer	Beatriz Rocha Ferreira (Master) Universidade do Minho, Portugal
2022	Intracerebral cerebrovascular calcifications as an etiological and prognosis biomarker in ischemic stroke: an exploratory study (Thesis) Main arguer	Adriana Filipa Batista Barros (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022	Study of the functional parameters of the autonomous nervous system in migraine patients (Thesis) Main arguer	Matilde Oliveira Farias (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022	Cervical cancer: what is the utility of p16 and other biomarkers in the diagnosis? (Thesis) Main arguer	Sara Guapo de Almeida Boom (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021	Animal models of Down's syndrome; applications and limitation in the study of the nervous system (Thesis) Arguer	Sofia Isabel Gonçalves Fernandes (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021	qPCR validation of genes differentially expressed in embryonic stem cells in response to decreased Cited2 expression (Thesis) Arguer	Filipe Vitorino (Other) Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2020	Silencing ATXN2 through CRISPR-mediated insertion of a premature STOP codon Supervisor	Ricardo Reis (Master) Universidade do Algarve, Portugal
2020	Non-codifying RNA molecules in the temporal control of embryonic development (Thesis) Arguer	André Filipe Coelho de Jesus (Other) Universidade do Algarve, Portugal
2020	Synaptic Plasticity: What changes in the Aging Brain? (Thesis) Arguer	Inês Alexandre Couto de Almeida (Other) Universidade do Algarve, Portugal
2020	Utilizing the dominant negative technique in the analysis of molecular and behavioural changes in the study of atypical Rett syndrome in zebra-fish (Thesis) Arguer	Pedro Miguel Xabregas Moreno dos Santos (Other) Universidade do Algarve, Portugal
2020	Development of the microglia and autism (Thesis) Arguer	Beatriz Passos Paulo (Other) Universidade do Algarve, Portugal
2020	Development of a lineage tracing strategy for the evaluation of substantia nigra regeneration in a Acomys cahirinus model of Parkinson’s disease (Thesis) Arguer	Giulia Fest Donnici (Other) Universidade do Algarve, Portugal
2020	Complementary approaches to the treatment of chronic pain: acupuncture and mindfulness (Thesis) Arguer	Vera Mascarenhas (Other) Universidade do Algarve, Portugal
2019	CRISPR-Cas9 as a tool for gene therapy in Machado-Joseph disease: silencing ATXN3 and CAG expansion correction Supervisor	André Filipe Vieira Conceição (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019	Utilizing bacteriophages as a means to tackle bacterial infections (Thesis) Arguer	Diana Sofia Carvalho Varela (Other) Universidade do Algarve, Portugal
2019	Development of a MCT8 gene knockout model using the CRISPR/Cas9 technology (Thesis) Arguer	Vanda Salgueiro Evaristo (Other) Universidade do Algarve, Portugal
2018	Multiplexed CRISPR activation of neuroprotective genes for Alzheimer´s Disease (Thesis) Main arguer	Fábio Duarte (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018	CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease Supervisor	Frederico Mendes e Pena (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018	Gene therapy for Huntington’s disease: molecular activation of autophagy (Thesis) Arguer	Ricardo Nunes (Other) Universidade do Algarve, Portugal
2018	Identification of neuronal cells dependent on thyroid hormones (Thesis) Arguer	Ana Rita Martins Luz (Other) Universidade do Algarve, Portugal
2018	Molecular activation of the autophagic pathway in Polyglutamine diseases (Thesis) Arguer	Raquel Lourenço das Neves Sequeira (Other) Universidade do Algarve, Portugal

Association member

	Society Organization name	Role
2025 - Current	European Society of Gene & Cell Therapy (ESGCT)	Effective member
2024/02/09 - Current	Ordem dos Farmacêuticos (Portuguese Order of Pharmacists)	Effective member
2022 - Current	Ataxia Global Initiative	Effective member
2020 - Current	Portuguese Society of Pharmacology (SPF)	Effective member
2013 - Current	Portuguese Society of Neuroscience (SPN)	Effective member
2013 - Current	Federation of European Neuroscience Societies (FENS)	Effective member

Committee member

	Activity description Role	Institution / Organization
2026 - Current	Member of the Coordinating Commission for Advanced Training Member	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025 - Current	ABC-Ri Green Group Member	Algarve Biomedical Center Research Institute, Portugal
2023 - Current	Member of the Course Committee of the PhD Program in Biomedical Sciences Member	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - Current	Member of the Scientific Council of the Algarve Biomedical Center Research Institute (ABC-RI) Member	Algarve Biomedical Center Research Institute, Portugal
2025 - 2025	Member of the Scientific Council Member	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2019 - 2021	Member of the Scientific Council of the Centre for Biomedical Research (CBMR) Member	Universidade do Algarve, Portugal
2017 - 2019	Elected member of the CNC.IBILI PostDoc representatives committee Member	CNC.IBILI, Portugal

Conference scientific committee

	Conference name	Conference host
2024 - Current	XIX Congress of the Portuguese Society of Diagnostic and Therapeutic Neurorradiology	Universidade do Algarve

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2025 - Current	Neurobiology	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2025 - Current	Molecular Pharmacology	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2023 - Current	Fundamentals of Bioinformatics	Ciências Biomédicas (Licenciatura)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current	Scientific Methods	Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current	Anatomophysiology I	Ciências Farmacêuticas (Mestrado integrado)	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Current	Basic and Clinical Sciences	Medicina (Mestrado integrado)	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - Current	Anatomy and Physiology	Bioengenharia (Licenciatura)	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2023 - Current	Molecular and Cellular Mechanisms	Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado)	Universidade do Algarve, Portugal
2023 - Current	Advances in Gene Therapies	Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado)	Universidade do Algarve, Portugal
2023 - Current	Development of New Medicines	Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado)	Universidade do Algarve, Portugal
2023 - Current	Anti-Cancer Drug Discovery	Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado integrado)	Universidade do Algarve, Portugal
2022 - Current	Practicals of Molecular Research	Ciências Biomédicas (Licenciatura)	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2020 - Current	Animal Models in Biomedical Research	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2020 - Current	Functional Organic Systems 301 - Nervous System And Special Senses	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2019 - Current	Gene and Cell Therapy	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2021 - 2025	OncoLab 2	Oncobiologia - Mecanismos Moleculares do Cancro (Mestrado integrado)	Universidade do Algarve, Portugal
2020 - 2024	Neurobiology	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2023 - 2023	Applications in Histology	Ciências Biomédicas (Licenciatura)	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018 - 2023	Advanced Systems of Gene and Cell Therapy	Ciências Biomédicas - Mecanismos de Doenças (Mestrado integrado)	Universidade do Algarve, Portugal
2014 - 2018	Do Gene à Proteína (From Gene to Protein). Theoretical and practical teaching of molecular cell biology techniques to high school students and teachers.	Molecular Cell Biology (Outros)	Instituto de Educação e Cidadania, Portugal

Evaluation committee

	Activity description Role	Institution / Organization
2024 - Current	Comission for the Evaluation and Selection of the candidates of the Integrated Master's in Medicine of the University of Algarve Member	Universidade do Algarve, Portugal
2022 - 2022	Member of the evaluation committee of the PhD candidates of the Biomedical Sciences Program at the Biomedical Sciences PhD Program Annual Journey Evaluator	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021 - 2021	Member of the evaluation committee of the PhD candidates of the Biomedical Sciences Program at the Biomedical Sciences PhD Program Annual Journey Evaluator	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal

Mentoring / Tutoring

	Topic	Student name
2026 - Current	Avaliação do efeito neuroprotetor de um agente farmacológico anti-envelhecimento num modelo roedor de doença de Machado-Joseph.	Ricardo Machado dos Santos
2026 - Current	escrição da história natural de um modelo roedor da síndroma de Cockayne: alterações neuropatológicas e motoras.	Maria Luís Ribeiro de Sousa
2021/07 - Current	PhD project: Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease	Ana Carolina Pinheiro da Silva
2022 - 2022	Systemic Hypertension Associated with Chronic Intermittent Hypoxia	Miguel António Figueira Domingos
2022 - 2022	Pre- and post-surgery incapacity in Inflammatory Bowel Disease – short- and long-term results evaluated by IBD DISK	Juliana Sofia Rodrigues Ferreira
2022 - 2022	Analysis of Cysteine and Homocysteine as biomarkers for Obstructive Sleep Apnea Syndrome and Arterial Hypertension	Diogo Alexandre Rosado Leça
2022 - 2022	Optimization of a cryopreservation protocol for future application in the isolation of Urine-Derived Stem Cells (UDSC) from patients with Amyotrophic Lateral Sclerosis	Beatriz Galhano Lopes
2020 - 2020	Laboratory Methods - Bioinformatic tools	Ana Letícia Fernandes Gomes

Other jury / evaluation

	Activity description	Institution / Organization
2025 - Current	Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2021/07/14 - Current	Jury of Ana Carolina Pinheiro da Silva PhD Thesis project "Development of an AAV-mediated allele-specific therapy for Machado-Joseph Disease" of	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2025 - 2025	Research Grant Applications reviewer	Ataxia UK, United Kingdom
2025 - 2025	Reviewer for the Funding Scheme OPUS-28 and OPUS-28 (LAP). Panel: NZ4 (Biology of tissues, organs and organisms). National Science Centre, Poland	Narodowe Centrum Nauki, Poland
2023 - 2023	Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022	Poster evaluation, in the context of the "Student-Selected Modules 1" course unit of the Integrated Master in Medicine	Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022	Poster evaluation at the Meeting of the Portuguese Society of Movement Disorders (SPDMov) - Classical and Atypical Parkinsonisms, Luso, Portugal	Sociedade Portuguesa das Doenças do Movimento, Portugal

Distinctions

Award

2024	Teaching and Learning Award from the University of Algarve 2023/24 Universidade do Algarve, Portugal
2024	Prémio Sociedade Farmacêutica Lusitana Ordem dos Farmaceuticos, Portugal
2023	Teaching and Learning Award from the University of Algarve 2021/22 Universidade do Algarve, Portugal

Other distinction

2020	Finalist of the Roche Building Tomorrow Together (Roche-BTT) Program
2009	Award for the best student from the Faculty of Sciences end Technology of the University of Coimbra 2008/09
2009	PhD Fellowship (SFRH/BD/47160/2008). Fundação para a Ciência e a Tecnologia, Portugal
2007	University of Coimbra's 3% Best Students Award Universidade de Coimbra, Portugal
2006	Merit Scholarship Universidade de Coimbra, Portugal
2006	University of Coimbra's 3% Best Students Award Universidade de Coimbra, Portugal
2005	Merit Scholarship Universidade de Coimbra, Portugal
2005	University of Coimbra's 3% Best Students Award Universidade de Coimbra, Portugal
2004	University of Coimbra's 3% Best Students Award Universidade de Coimbra, Portugal

	Activity description Type of event	Event name Institution / Organization
2026/12/16 - 2026/12/17	Jornada Anual dos Doutorandos do Programa Doutoral em Ciências Biomédicas 2025 Meeting	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2025/10/17 - 2025/10/17	Gene therapy frontiers for brain symposium, a molecular and neuroscience gene therapy edition - 1st edition of Neurochemical and neurogenetic aspects of neurodegenerative and rare brain diseases: Implications for future therapeutic approaches. Symposium	Algarve Biomedical Center Research Institute, Portugal
2025/10/07 - 2025/10/10	European Society of Gene & Cell Therapy/ Sociedad Española de Terapia Génica y Celular (ESGCT/SETGYC) Collaborative Congress Congress	European Society of Gene & Cell Therapy (ESGCT), Germany
2025/09/27 - 2025/09/27	Congresso – O Futuro das Ataxias Congress	Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2025/05/30 - 2025/05/30	“Fostering inclusive mentorship”. ALBA Session Mentor at XIX Reunião Anual da Sociedade Portuguesa de Neurociências (SPN) Round table	Sociedade Portuguesa de Neurociências, Portugal
2025/05/28 - 2025/05/30	XIX Reunião da Sociedade Portuguesa de Neurociências (SPN) Meeting	Sociedade Portuguesa de Neurociências, Portugal
2024/12/16 - 2024/12/17	Jornada Anual dos Doutorandos do Programa Doutoral em Ciências Biomédicas 2024 Meeting	Universidade do Algarve, Faculdade de Medicinas e Ciências Biomédicas, Portugal
2024/11/12 - 2024/11/15	International Congress for Ataxia Research (ICAR) Congress	Ataxia UK, United Kingdom National Ataxia Foundation, United States
2024/09/26 - 2024/09/28	19º Congresso da Sociedade Portuguesa de Neurorradiologia Diagnóstica e Terapêutica (SPNR) Congress	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2024/02/07 - 2024/02/09	LIV Meeting of the Portuguese Society of Pharmacology (SPF) Meeting	LIV Meeting of the Portuguese Society of Pharmacology (SPF) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/12/19 - 2023/12/20	Biomedical Sciences PhD Program Annual Journey Meeting	Biomedical Sciences PhD Program Annual Journey Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023/11/17 - 2023/11/17	5ª Edition of Doctoral Conversations: "Evolution of Humanity and Environmental Adaptations" Meeting	5ª Edition of Doctoral Conversations: "Evolution of Humanity and Environmental Adaptations" Universidade do Algarve, Portugal
2023/10/29 - 2023/11/04	ESN-ISN Neurochemistry School 2023 (2023/10/29 - 2023/11/04) Other	Algarve Biomedical Center Research Institute, Portugal
2023/05/03 - 2023/05/05	FENS Regional Meeting 2023 - Algarve Meeting	FENS Regional Meeting 2023 – Algarve Algarve Biomedical Center Research Institute, Portugal
2023/02/17 - 2023/02/17	Round table discussion under the subject "From the reconfiguration of the organic: genomic editing" Round table	Public Session of the Portuguese National Ethics Council for the Life Sciences Conselho Nacional de Ética para as Ciências da Vida, Portugal
2023/02/17 - 2023/02/17	Public Session of the Portuguese National Ethics Council for the Life Sciences , as part of the Report on the State of the Application of New Technologies to Human Life 2022 “Dysruptive Health Technologies”. Faro, Portugal. Conference	Public Session of the Portuguese National Ethics Council for the Life Sciences , as part of the Report on the State of the Application of New Technologies to Human Life 2022 “Dysruptive Health Technologies” Conselho Nacional de Ética para as Ciências da Vida, Portugal
2023 - 2023	44th European Pharmaceutical Students' Associations (EPSA) Annual Congress, Podcetrtek, Slovenia Congress	44th European Pharmaceutical Students' Associations (EPSA) Annual Congress
2023 - 2023	MEEting 2023, Faro, Portugal. Meeting	MEEting 2023 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2023 - 2023	Open Day of the University of Algarve Other	Open Day of the University of Algarve Universidade do Algarve, Portugal
2023 - 2023	3rd International Congress of History of Science in Teaching Congress	3rd International Congress of History of Science in Teaching Universidade do Algarve, Portugal
2022/12/19 - 2022/12/20	Biomedical Sciences PhD Program Annual Journey Meeting	Biomedical Sciences PhD Program Annual Journey Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022	Round table discussion on the role of research in the access to a directed therapy Round table	National Ataxias Congress Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2022 - 2022	Meeting of the Portuguese Society of Movement Disorders (SPDMov) - Classical and Atypical Parkinsonisms Meeting	Meeting of the Portuguese Society of Movement Disorders (SPDMov) – Classical and Atypical Parkinsonisms Sociedade Portuguesa das Doenças do Movimento, Portugal
2022 - 2022	Moderation of seminar sessions of the ABC-RI International Forum Spring Edition 2022 – Gene and Cell Therapies for Healthy Ageing Symposium	ABC-RI International Forum Spring Edition 2022 – Gene and Cell Therapies for Healthy Ageing Algarve Biomedical Center Research Institute, Portugal
2022 - 2022	Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) Meeting	Ageing without borders - Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal Algarve Biomedical Center Research Institute, Portugal
2022 - 2022	ABC Days - V National Meeting of the Algarve Biomedical Center. Sagres, Portugal. Meeting	ABC Days - V National Meeting of the Algarve Biomedical Center Algarve Biomedical Center, Portugal
2022 - 2022	I National Ataxias Congress Meeting	I National Ataxias Congress Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2022 - 2022	MEEting 2022, Faro, Portugal Meeting	MEEting 2022 Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2022 - 2022	FIC.A (Festival Internacional de Ciência, International Science Festival), Oeiras, Portugal Exhibition	FIC.A (Festival Internacional de Ciência, International Science Festival)
2021/12 - 2021/12	XVII Meeting of the Portuguese Society for Neuroscience (SPN) Meeting	XVII Meeting of the Portuguese Society for Neuroscience (SPN) Sociedade Portuguesa de Neurociências, Portugal
2021/12 - 2021/12	Biomedical Sciences PhD Program Annual Journey Meeting	Biomedical Sciences PhD Program Annual Journey Universidade do Algarve Faculdade de Medicina e Ciências Biomédicas, Portugal
2021/10 - 2021/10	IV Jornadas Algarve Biomedical Center Meeting	IV Jornadas Algarve Biomedical Center Algarve Biomedical Center, Portugal
2021/05/24 - 2021/05/28	The CRISPR Revolution: a workshop on gene editing, from cells to animal models. Workshop	The CRISPR Revolution: a workshop on gene editing, from cells to animal models Universidade do Algarve, Portugal
2021/04/26 - 2021/04/27	JCB–JEM 2021 Symposium on Neurodegeneration Symposium	JCB–JEM 2021 Symposium on Neurodegeneration The Rockefeller University Press, United States
2021 - 2021	XLXI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Lisbon, Portugal. Conference	XLXI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF) Sociedade Portuguesa de Farmacologia, Portugal
2021 - 2021	Ataxias, um mundo - Avanços no desenvolvimento de novas terapias (Ataxias - Advances in the development of novel therapies) Meeting	Associação Portuguesa de Ataxias Hereditárias (APAHE), Portugal
2020 - 2020	XLX Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Coimbra, Portugal. Conference	XLX Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF) Sociedade Portuguesa de Farmacologia, Portugal
2019 - 2019	XVI Meeting of the Portuguese Society for Neuroscience (SPN), Lisbon, Portugal Conference	XVI Meeting of the Portuguese Society for Neuroscience (SPN) Sociedade Portuguesa de Neurociências, Portugal
2019 - 2019	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI). Coimbra, Portugal. Conference	53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) European Society for Clinical Investigation, Netherlands
2019 - 2019	3as Jornadas Algarve Biomedical Center. Albufeira, Portugal. Conference	3as Jornadas Algarve Biomedical Center Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
2018 - 2018	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Lisbon, Portugal. Congress	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Sociedade Portuguesa de Farmacologia, Portugal
2018 - 2018	Workshop "Visual Communication Graphical abstracts". PostDocs@UC, University of Coimbra, Coimbra, Portugal. Workshop	Visual Communication Graphical abstracts Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017 - 2017	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Coimbra, Portugal. Conference	XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF) Sociedade Portuguesa de Farmacologia, Portugal
2017 - 2017	EMBO Practical Course on Mouse Genome Engineering. Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany. Other	EMBO Practical Course on Mouse Genome Engineering Max-Planck-Institut für molekulare Zellbiologie und Genetik, Germany
2016 - 2016	10th World Congress on Controversies in Neurology (CONy) – Workshop in Machado-Joseph disease Workshop	10th World Congress on Controversies in Neurology (CONy) – Workshop in Machado-Joseph disease
2016 - 2016	XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF). Porto, Portugal Conference	XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia (SPF) Sociedade Portuguesa de Farmacologia, Portugal
2016 - 2016	1st Brain without Borders International Symposium. Coimbra, Portugal. Symposium	1st Brain without Borders International Symposium CNC.IBILI, Portugal
2015/05/28 - 2015/05/28	Integration of PhD holders in Companies: Challenges and Solutions for the Future (Integração de Doutorados nas Empresas: Desafios e Soluções para o Futuro) Symposium	Integração de Doutorados nas Empresas: Desafios e Soluções para o Futuro Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015 - 2015	Ineo start – technology transfer and business plan acceleration program. Instituto Pedro Nunes (IPN), Coimbra, Portugal. Other	Ineo start – technology transfer and business plan acceleration program Associação para a Inovação e Desenvolvimento em Ciência e Tecnologia, Portugal
2015 - 2015	Workshop "CRISPR Tools in Genetically Tractable Organisms". Fundação Champalimaud, Lisboa, Portugal. Workshop	CRISPR Tools in Genetically Tractable Organisms Fundação Champalimaud, Portugal
2014 - 2014	XVIII Congress of the Portuguese Biochemical Society (SPB). Coimbra, Portugal. Congress	XVIII Congress of the Portuguese Biochemical Society (SPB) Sociedade Portuguesa de Bioquímica, Portugal
2014 - 2014	5th Ataxia Investigators Meeting. Las Vegas, USA. Conference	5th Ataxia Investigators Meeting National Ataxia Foundation, United States
2014 - 2014	Laboratory Animal Sciences Course - B Category. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. Other	aboratory Animal Sciences Course - B Category CNC.IBILI, Portugal
2013 - 2013	Champalimaud Neuroscience Programme Symposium. Lisbon, Portugal. Symposium	Champalimaud Neuroscience Programme Symposium Programa Champalimaud de Neurociências, Portugal
2013 - 2013	XIII Meeting of the Portuguese Society for Neuroscience (SPN), Luso, Portugal. Conference	XIII Meeting of the Portuguese Society for Neuroscience (SPN) Sociedade Portuguesa de Neurociências, Portugal
2013 - 2013	XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Coimbra, Portugal. Meeting	XI Center for Neuroscience and Cell Biology (CNC) Annual Meeting CNC.IBILI, Portugal
2013 - 2013	Workshop "The nematode C. elegans – a model for biomedical research". Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal. Workshop	The nematode C. elegans – a model for biomedical research Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012 - 2012	8th Federation of European Neurosciences (FENS) Forum of Neuroscience, Barcelona, Spain. Conference	8th Federation of European Neurosciences (FENS) Forum of Neuroscience Federation of European Neuroscience Societies, Belgium
2012 - 2012	1st Doctoral Programme in Experimental Biology and Biomedicine (BEB) Symposium – Science dreams, challenges arise, Coimbra, Portugal Symposium	1st Doctoral Programme in Experimental Biology and Biomedicine (BEB) Symposium – Science dreams, challenges arise CNC.IBILI, Portugal
2012 - 2012	X Center for Neuroscience and Cell Biology (CNC) Annual Meeting, Cantanhede, Portugal. Meeting	X Center for Neuroscience and Cell Biology (CNC) Annual Meeting CNC.IBILI, Portugal
2011 - 2011	Gordon Research Conference on CAG Triplet Disorders, Luca, Italy.	Gordon Research Conference on CAG Triplet Disorders Gordon Research Conferences, United States