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Ângela Carvalho graduated in Biomedical Engineering at the Polytechnic Institute of Porto (IPP) and obtained her Master's Degree at the Faculty of Engineering of the University of Porto (FEUP), initiating her research activities in 2012 at INEB. She later obtained her PhD in Biomedical Engineering at FEUP, in 2018 (Cum Laude). As a Postdoc at i3S, she launched a new research line in cancer precision medicine within her group, having coordinated a project developed in collaboration with IPO-Porto and funded by FCT (TRIMARKCHIP). The focus was on liquid biopsies, specifically the development of novel microfluidic platforms for detection and isolation of circulating tumour biomarkers for lung cancer management. Main outputs include the identification of novel biomarkers in lung cancer circulating tumor cells (patent application: PT 119401). She has authored and co-authored 27 peer-reviewed publications, with 441 citations and an h-index of 12. Has supervised/currently supervises 9 students (1 BSc, 6 MSc and 2 PhD candidates) and has mentored 8 students (including 4 PhD students). Participation in projects includes 8 national and international projects, establishing collaborations with 12 national and international teams, with over 70 co-authors. Science outreach activities involve participation in school's programs, fundraising activities, scientific committees for conferences, and lectures. Having a high focus on the translation of research into health-improving products, she transitioned to a role in technology transfer as the project manager of RESOLVE-Health 2.0, an acceleration program to boost technology transfer and value creation in health. In the role, she supported entrepreneurs and startups to navigate technology transfer and product and market validation. Currently, she is co-founder & CEO of BEAT Therapeutics, a biotech startup working towards developing first-in-class targeted therapies to fight the most challenging and resistant forms of cancer. Has received several distinctions related to entrepreneurship and innovation, including the Women TechEU award.
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Identification

Personal identification

Full name
Angela Carvalho
Date of birth
1988/03/07
Gender
Female

Citation names

  • A. Carvalho
  • Carvalho, A.
  • Carvalho, Angela

Author identifiers

Ciência ID
DB1F-D036-FFF5
ORCID iD
0000-0002-4837-6539
Google Scholar ID
https://scholar.google.com/citations?user=1oxTay4AAAAJ&hl=pt-PT
Researcher Id
L-3224-2014
Scopus Author Id
55851941060

Email addresses

  • angela.carvalho@beattherapeutics.com (Professional)
  • ang.carvalho4@gmail.com (Personal)

Addresses

  • UPTEC - Rua Alfredo Allen 455-461, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2013/01 - 2018/02
Concluded
 Doctoral Program in Biomedical Engineering (Doutoramento) (Doutoramento)
Universidade do Porto Faculdade de Engenharia, Portugal
"Microfabricated surfaces for guided tissue regeneration" (THESIS/DISSERTATION)
 Approved CUM LAUDE
2016/04/01 - 2016/04/28
Concluded
 Visiting Researcher: Doctoral Program in Biomedical Engineering (Doutoramento)
Institute of Electronics of the Bulgarian Academy of Sciences, Bulgaria
2015/04/01 - 2015/08/15
Concluded
 Visiting Researcher: Doctoral Program in Biomedical Engineering (Doutoramento)
The Ohio State University, United States
2013/11/01 - 2013/11
Concluded
 Visiting Researcher: Doctoral Program in Biomedical Engineering (Doutoramento)
Instituto de Cerámica y Vidrio, Spain
2009/09 - 2011/10
Concluded
 Master in Biomedical Engineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
"Development of nanostructured and bioactive surfaces onto ceramic substrates" (THESIS/DISSERTATION)
 17
2006/10 - 2009/07
Concluded
 Licenciatura em Engenharia Biomédica (Licenciatura)
Instituto Politécnico do Porto, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2022/07 - 2023/06 Science and Technology Management Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
RESOLVE Health Program, Portugal
2018/03/01 - 2022/04 Contracted Researcher (Research) Instituto Nacional de Engenharia Biomédica, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/02/01 - 2018/02/28 Research Assistant (Research) Universidade do Porto Faculdade de Engenharia, Portugal
2012/01/02 - 2012/12/31 Research Assistant (Research) Instituto Nacional de Engenharia Biomédica, Portugal

Others

Category
Host institution 		Employer
2023/08 - Current Co-founder & CEO BEAT Therapeutics, Portugal
2020/03 - 2020/08 Volunteer in the i3S COVID-19 taskforce - PCR tests for SARS-CoV-2 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01 - 2016/12 PhD student granted an FCT scholarship (SFRH/BD/87624/2012) Fundação para a Ciência e a Tecnologia, Portugal
Instituto Nacional de Engenharia Biomédica, Portugal
(...)
Projects

Grant

Designation Funders
2016 - 2017 COST Action MP1301
MP1301
 European Cooperation in Science and Technology
2013/01/01 - 2016/12/31 Microfabricated surfaces for guided tissue regeneration
SFRH/BD/87624/2012
PhD Student Fellow
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/05/03 - 2012/12/31 Bone response to nanostructured and micropatterned surface modified Zirconia dental implants - BONAMIDI
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/100120/PT
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2022/07 - 2023/06 RESOLVE 2.0 (Respostas Específicas para Superar Obstáculos que Limitam a Valorização Eficaz)
POCI-01-0246-FEDER-181287
Science and Technology Management Fellow
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Concluded
2019/01/02 - 2022/04 Assessing the trifecta of cancer circulating biomarkers: a combined microfluidics platform for detection of CTCs, exosomes and ctDNA
PTDC/BTM-TEC/30831/2017
POCI-01-0145-FEDER-030831
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia

Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Ongoing
2018/03/01 - 2018/12/31 Structured program on bioengineered therapies for infectious diseases and tissue regeneration
NORTE-01.0145-FEDER-000012
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Comissão de Coordenação da Região Norte
Concluded

Other

Designation Funders
2018/08 - 2019/09 HECOLCAP - The one-step solution for chronic bone infections
CI18-00021
Translational Research | Medical device standardization
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação La Caixa
Concluded
2017/03/01 - 2018/04 Novel approach to the therapy for bone infection treatment based on bioactive composite Biomaterials (HECOLCAP)
Norte-01-0246-FEDER-000018
Translational Research | Medical device standardization
Instituto Nacional de Engenharia Biomédica, Portugal
 RESOLVE Health Program
Concluded
2015/12 - 2017/09 New Generation Biomimetic and Customized Implants For Bone Engineering
COST Action MP1301
Other
European Cooperation in Science and Technology, Belgium
 European Cooperation in Science and Technology
Concluded
Outputs

Publications

Book chapter
  1. T. Esteves; A. Carvalho ; F. J. Monteiro; P. Quelhas. "Periodic Background Pattern Detection and Removal for Cell Tracking". In Lecture Notes in Computer Science, edited by Campilho, Aurélio; Kamel, Mohamed, 123-131. Springer International Publishing, 2014.
    10.1007/978-3-319-11755-3_14
  2. A. Pelaez-Vargas; D. Gallego-Perez; N. Higuita-Castro; A. Carvalho ; L. Grenho; J.A. Arismendi; M.H. Fernandes; et al. "Micropatterned Coatings for Guided Tissue Regeneration in Dental Implantology". In Cell Interaction, edited by Sivakumar Gowder. Rijeka, Croatia: InTech, 2012.
    10.5772/50838
Conference abstract
  1. A. Carvalho ; T. Esteves; P. Quelhas; F.J. Monteiro. "Assessing cell motility on line and pillar microengineered surfaces: An automatic tool to detect and track cells in brightfield microscopy". Paper presented in TERMIS - European Chapter. Published in eCM, Rhodes, 2019.
    Published
  2. G. As. Georgiev; A. Daskalova; L. S. Petrov; P. Eftimov; A. Carvalho ; F. J. Monteiro; I. Buchvarov. "Biomimetic Structuring and Wettability Control of Alumina Toughened Zirconia Composite Ceramics Utilizing Laser Surface Processing". Paper presented in Laser Congress 2019 (ASSL, LAC, LS&C), Vienna, 2019.
    Published • 10.1364/assl.2019.jw2a.50
  3. A. Carvalho ; R. Vilar; M.H. Fernandes; F.J. Monteiro. "Human bone marrow derived mesenchymal stem cells modulation by micro/nanostructured ATZ surfaces treated with femtosecond laser". Paper presented in 10th World Biomaterials Congress, Montreal, 2016.
    Published • 10.3389/conf.fbioe.2016.01.02423
  4. A. Carvalho ; A. Pelaez-Vargas; D.J. Hansford; M.H. Fernandes; M. P. Ferraz; F.J. Monteiro. "Cells and bacteria behaviour on micropatterned isotropic and anisotropic bioactive surfaces". Paper presented in 4th International Symposium on Surfaces and Interfaces for Biomaterials - Published in eCM, Rome, 2013.
    Published
  5. A. Carvalho ; A. Pelaez-Vargas; D.J.Hansford; M.H.Fernandes; M.P. Ferraz; F.J. Monteiro. "Micropatterned bioactive thin films for guided bone regeneration". Paper presented in SSB2012 - 18th Swiss Conference in Biomaterials. Published in eCM, Zurich, 2012.
    Published
  6. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; M.H. Fernandes; D.J. Hansford; F.J. Monteiro. "Adhesion and proliferation of mesenchymal stem cells on micropatterned thin films modified with nanohydroxyapatite particles". Paper presented in 3rd Joint Meeting of the European Calcified Tissue Society & the International Bone and Mineral Society, Athens, 2011.
    Published • 10.1016/j.bone.2011.03.169
Conference paper
  1. Santos Silva, Filipe; Rosa, Natacha; Carvalho, Angela ; Santos, Flavia; Monteiro, Ana; Macedo, Bárbara; Prazeres, Hugo. "Unprecedented Living Lab Approach: Technological Innovations for Paediatric Cancer Support System". Paper presented in 18th European Conference on Innovation and Entrepreneurship, Porto, 2023.
    Published
Conference poster
  1. C. Lourenço; N. Tavares; V. Constâncio; C. Martins-Lima; A. Teixeira-Marques; S. Monteiro-Reis; A. Carvalho ; C. Jerónimo. Corresponding author: C. Lourenço. "Profile and signature of bladder cancer-derived extracellular vesicles". Paper presented in 6th ASPIC International Congress, 2024.
  2. C. Lourenço; N. Tavares; V. Constâncio; S. Monteiro-Reis; S. Paulino; F. Lobo; A. Rodrigues; A. Carvalho ; C. Jerónimo. Corresponding author: C. Lourenço. "Understanding EV cancer communication through proteomic signature: from tissue to liquid biopsies". Paper presented in European Association for Cancer Research (EACR), 2024.
  3. Lourenço, C; Maia, J; Suriyanarayanan, S; Marques, P; Nicholls, I; Carvalho, A. ; Jerónimo, Carmen. "EMBRACIVE – A microfluidic assisted technology for non-invasive identification and characterization of extracellular vesicles in bladder cancer patients". Paper presented in 1st Young Researcher’s Day, 2023.
  4. Mazeda, João; Fernando Jorge Monteiro; Carvalho, Angela. "A Microfluidics Approach for Minimally Invasive Isolation and Protein Profiling of CTCs in Lung Cancer". Paper presented in Encontro de Jovens da U.Porto- IJUP, 2022.
  5. A. Carvalho ; G. Ferreira; D. Seixas; V. Constâncio; F.J. Monteiro; C. Jerónimo. "A microfluidic-based approach for combinatorial assessment of CTCs and cfDNA methylation in lung cancer". Paper presented in European Association for Cancer Research Virtual Congress (EACR 2021), 2021.
  6. A. Carvalho ; G. Ferreira; D. Seixas; V. Constâncio; F.J. Monteiro; C. Jerónimo. "A microfluidics device for combined assessment of biomarkers in lung cancer: CTCs isolation by size with downstream methylation analysis of cfDNA". Paper presented in 27th PORTO CANCER MEETING, 2021.
  7. M. Fernandes; G. Ferreira; F.J. Monteiro; A. Carvalho. "Isolation and in-chip characterization of lung cancer circulating tumour cells (CTCs) using a microfluidics device". Paper presented in IJUP - Encontro Investigação Jovem 14a Edição, 2021.
  8. G. As. Georgiev; A. Daskalova; L. S. Petrov; P. Eftimov; A. Carvalho ; F.J. Monteiro; I. Buchvarov. "Biomimetic Structuring and Wettability Control of Alumina Toughened Zirconia Composite Ceramics Utilizing Laser Surface Processing". Paper presented in OSA Laser Congress, 2019.
    10.1364/assl.2019.jw2a.50
  9. A. Carvalho ; L. Cangueiro; V. Oliveira; R. Vilar; M.H. Fernandes; F.J. Monteiro. "Modulating the race for the surface: Femtosecond laser micro/nanopatterning of Alumina toughened Zirconia to improve osteogenic response and diminish bacterial adhesion". Paper presented in 29th European Conference on Biomaterials (ESB), 2018.
  10. A. Carvalho ; L. Cangueiro; V. Oliveira; R. Vilar; M.H. Fernandes; F.J. Monteiro. "hMSCs osteogenic differentiation on femtosecond laser microstructured ceramics". Paper presented in 6th China-Europe Symposium on Biomaterials in Regenerative Medicine, 2017.
  11. A. Carvalho ; D.J. Hansford; A. Pelaez-Vargas; D. Gallego-Perez; N. Higuita-Castro; M.S. Laranjeira; L. Grenho; F.J. Monteiro. "Micro/nanostructured silica coatings modulate dental tissue attachment and orientation on ceramic implants". Paper presented in 10th Annual T2C Regenerative Medicine Wound Care Conference, 2017.
  12. A. Carvalho ; R. Vilar; M.H. Fernandes; F.J. Monteiro. "Human bone marrow stromal cells behavior on micro/nanostructured ATZ ceramics treated by femtosecond laser". Paper presented in 5th i3S Annual Meeting, 2016.
  13. R. Miranda; A. Carvalho ; F.J. Monteiro; P.F. César. "Caracterização de uma zircônia tetragonal estabilizada com ítria após recobrimento superficial com um filme bioativo de silica micropadronizada com nanohidroxiapatita". Paper presented in 9° Congresso Latino-Americano de Orgãos Artificiais e Biomateriais (COLAOB) e 13° Congresso da Sociedade Latino Americana de Biomateriais, Orgãos Artificiais e Engenharia de Tecidos (SLABO), 2016.
  14. A. Carvalho ; A. Pelaez-Vargas; D.J. Hansford; M.H. Fernandes; F.J. Monteiro. "Line and Pillar micropatterned surfaces induce hMSCs osteogenic differentiation". Paper presented in Interactions between materials and host tissues - COST MP1301 NEWGEN Workshop, 2016.
  15. A. Carvalho ; M.H. Fernandes; F.J. Monteiro. "Zirconia substrates with micropatterned SiO2 coatings for guided bone regeneration". Paper presented in MATERIAIS 2015, VII International Materials Symposium | XVII Conference of Sociedade Portuguesa dos Materiais, 2015.
  16. A. Carvalho ; T. Esteves; F.J. Monteiro; P. Quelhas. "Detection and removal of periodic background patterns for improving of cell tracking analysis". Paper presented in DCE – 2015 Symposium on Electrical and Computer Engineering, 2015.
  17. T. Esteves; A. Carvalho ; F.J. Monteiro; P. Quelhas. "Periodic background pattern detection and removal for cell tracking". Paper presented in International Conference on Image Analysis and Recognition ICIAR, 2014.
  18. A. Carvalho ; T. Esteves; P. Quelhas; F.J. Monteiro. "An automated MATLAB tool to quantify cell migration on micropatterned surfaces". Paper presented in 4th I3S Annual Meeting, 2014.
  19. A. Carvalho ; A. Pelaez-Vargas; D.J. Hansford; M.H. Fernandes; F.J. Monteiro. "Human Bone Marrow Stromal Cells osteogenic differentiation on micropatterned silica surfaces". Paper presented in Winter Science Club, 2013.
  20. M.S. Laranjeira; A. Carvalho ; M.P. Ferraz; E. Costa; A. Santos-Silva; F.J. Monteiro. "Bacterial adhesion and hemolitic properties of micropatterned silica surfaces produced by soft-lithography". Paper presented in Winter Science Club, 2013.
  21. A. Carvalho ; A. Pelaez-Vargas; D. J. Hansford; M. P. Ferraz; F.J. Monteiro. "Adhesion of Streptococcus gordonii to isotropic and anisotropic micropatterned silica thin films". Paper presented in 3rd Advanced Summer School Interrogations at the Biointerface: Inflammation/Repair Interface, 2013.
  22. A. Carvalho ; A. Pelaez-Vargas; D.J. Hansford; M.P. Ferraz; F.J. Monteiro. "Streptococcus gordonii initial adhesion to micropatterned silica surfaces". Paper presented in Winter Science Club, 2012.
  23. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; M.H. Fernandes; D. J. Hansford; F.J. Monteiro. "hMSCs osteogenic differentiation on microstructured surfaces". Paper presented in 7º COLAOB – Congresso Latino-Americano de Orgãos Artificiais e Biomateriais, 2012.
  24. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; M.H. Fernandes; D.J. Hansford; F.J. Monteiro. "Micropatterned bioactive thin films for guided bone regeneration". Paper presented in 18th Swiss Conference in Biomaterials (SB2012), 2012.
  25. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; M.H. Fernandes; D.J. Hansford; F.J. Monteiro. "Micropatterned silica coatings for osteogenic differentiation". Paper presented in 3rd I3S Scientific Retreat, 2012.
  26. R. Sousa; A. Pelaez-Vargas; A. Carvalho ; L. Grenho; M.P. Ferraz; D.J. Hansford; F.J. Monteiro. "Microfabrication strategies to study biofilms produced by oral bacteria". Paper presented in Winter Science Club, 2011.
  27. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; M.H. Fernandes; D.J. Hansford; F.J. Monteiro. "Adhesion and proliferation of Mesenchymal Stem Cells on micropatterned thin films modified with nanohydroxyapatite particles". Paper presented in 3rd Joint Meeting of the European Calcified Tissue Society & the International Bone and Mineral Society, 2011.
  28. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; M.H. Fernandes; D.J. Hansford; F.J. Monteiro. "Biological Characterization of Bioactive Thin Films Produced by Microstamping". Paper presented in 2nd i3S Scientific Retreat, 2011.
Journal article
  1. Nuno Alegrete; Susana R. Sousa; Tatiana Padrão; Ângela Carvalho; Raquel Lucas; Raphael F. Canadas; Catarina Lavrador; et al. "Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatment: In Vivo Rabbit Toxicological Tests and In Vivo Efficacy Tests in a Sheep Model". Bioengineering (2023): https://doi.org/10.3390/bioengineering10020206.
    10.3390/bioengineering10020206
  2. Denis Horgan; Tanja Cufer; Francesco Gatto; Iwona Lugowska; Donatella Verbanac; Ângela Carvalho; Jonathan A. Lal; et al. "Accelerating the Development and Validation of Liquid Biopsy for Early Cancer Screening and Treatment Tailoring". Healthcare (2022): https://doi.org/10.3390/healthcare10091714.
    10.3390/healthcare10091714
  3. Ângela Carvalho; Catarina Guimarães-Teixeira; Vera Constâncio; Mariana Fernandes; Catarina Macedo-Silva; Rui Henrique; Fernando Jorge Monteiro; Carmen Jerónimo. "One sample fits all: a microfluidic-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer". Biomaterials Science (2022): https://doi.org/10.1039/D2BM00044J.
    10.1039/D2BM00044J
  4. A. Carvalho; C. Guimarães-Teixeira; V. Constâncio; M. Fernandes; C. Macedo-Silva; R. Henrique; F.J. Monteiro; C. Jerónimo. "A microfluidics-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer". bioRxiv (2022):
    https://doi.org/10.1101/2022.02.28.482380
  5. A. Moreira; S. Madeira; M. Buciumeanu; J. Fialho; A. Carvalho ; F. Silva; F. J. Monteiro; J. Caramês. "Design and surface characterization of micropatterned silica coatings for zirconia dental implants". Journal of the Mechanical Behavior of Biomedical Materials (2021): 105060-105060.
    http://dx.doi.org/10.1016/j.jmbbm.2021.105060
  6. A. Carvalho ; G. Ferreira; D. Seixas; C. Guimarães-Teixeira; R. Henrique; F. J. Monteiro; C. Jerónimo. "Emerging Lab-on-a-Chip Approaches for Liquid Biopsy in Lung Cancer: Status in CTCs and ctDNA Research and Clinical Validation". Cancers (2021):
    https://doi.org/10.3390/cancers13092101
  7. C. Lourenço; V. Constâncio; R. Henrique; A. Carvalho ; C. Jerónimo. "Urinary Extracellular Vesicles as Potential Biomarkers for Urologic Cancers: An Overview of Current Methods and Advances". Cancers 13 7 (2021): 1529.
    http://dx.doi.org/10.3390/cancers13071529
  8. S. Grabska-Zielinska; A. Sionkowska; A. Carvalho ; F.J. Monteiro. "Biomaterials with Potential Use in Bone Tissue Regeneration - Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS". Materials 14 5 (2021):
    https://doi.org/10.3390/ma14051105
  9. A. Carvalho ; L. Grenho; M.H.Fernandes; A. Daskalova; A. Trifonov; I. Buchvarov; F.J. Monteiro. "Femtosecond laser microstructuring of alumina toughened zirconia for surface functionalization of dental implants". Ceramics International 46 2 (2020): 1383-1389.
    http://dx.doi.org/10.1016/j.ceramint.2019.09.101
  10. A. Daskalova; L. Angelova; A. Carvalho ; A. Trifonov; C. Nathala; F.J. Monteiro; I. Buchvarov. "Effect of Surface Modification by Femtosecond Laser on Zirconia Based Ceramics for Screening of Cell-Surface Interaction". Applied Surface Science (2020): 145914.
    http://dx.doi.org/10.1016/j.apsusc.2020.145914
  11. A. Carvalho ; T. Esteves; P. Quelhas; F.J. Monteiro. "MobilityAnalyser: A novel approach for automatic quantification of cell mobility on periodic patterned substrates using brightfield microscopy images". Computer Methods and Programs in Biomedicine 162 (2018): 61-67.
    http://dx.doi.org/10.1016/j.cmpb.2018.05.003
  12. R.B.P. Miranda; L. Grenho; A. Carvalho ; M.H. Fernandes; F. J. Monteiro; P.F. Cesar. "Micropatterned Silica Films with Nanohydroxyapatite for Y-TZP Implants". Journal of Dental Research 97 9 (2018): 1003-1009.
    http://dx.doi.org/10.1177/0022034518765762
  13. A. Carvalho ; L. Cangueiro; V. Oliveira; R. Vilar; M.H. Fernandes; F.J. Monteiro. "Femtosecond laser microstructured Alumina toughened Zirconia: A new strategy to improve osteogenic differentiation of hMSCs". Applied Surface Science 435 (2018): 1237-1245. http://dx.doi.org/10.1016/j.apsusc.2017.11.206.
    10.1016/j.apsusc.2017.11.206
  14. B. Kaczmarek; A. Sionkowska; F.J. Monteiro; A. Carvalho ; K. Lukowicz; A. M. Osyczka. "Characterization of gelatin and chitosan scaffolds cross-linked by addition of dialdehyde starch". Biomedical Materials 13 1 (2017): 015016.
    http://dx.doi.org/10.1088/1748-605x/aa8910
  15. A. Carvalho ; A. Pelaez-Vargas; D.J.Hansford; M.H. Fernandes; F.J. Monteiro. "Effects of Line and Pillar Array Microengineered SiO2 Thin Films on the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells". Langmuir 32 4 (2016): 1091-1100.
    http://dx.doi.org/10.1021/acs.langmuir.5b03955
  16. M.S. Laranjeira; A. Carvalho ; A. Pelaez-Vargas; D.J.Hansford; M.P. Ferraz; S. Coimbra; E. Costa; et al. "Modulation of human dermal microvascular endothelial cell and human gingival fibroblast behavior by micropatterned silica coating surfaces for zirconia dental implant applications". Science and Technology of Advanced Materials 15 2 (2014): 025001.
    http://dx.doi.org/10.1088/1468-6996/15/2/025001
  17. A. Pelaez-Vargas; D. Gallego-Perez; A. Carvalho (DB1F-D036-FFF5); M.H. Fernandes; D.J. Hansford; F. J. Monteiro (5B1E-8842-AD62). "Effects of density of anisotropic microstamped silica thin films on guided bone tissue regeneration-In vitro study". Journal of Biomedical Materials Research Part B: Applied Biomaterials 101B 5 (2013): 762-769.
    http://dx.doi.org/10.1002/jbm.b.32879
  18. A. Carvalho ; A. Pelaez-Vargas; D. Gallego-Perez; L. Grenho; M.H.Fernandes; A.H. De Aza; M.P. Ferraz; D.J.Hansford; F.J. Monteiro. "Micropatterned silica thin films with nanohydroxyapatite micro-aggregates for guided tissue regeneration". Dental Materials 28 12 (2012): 1250-1260.
    http://dx.doi.org/10.1016/j.dental.2012.09.002
Preprint
  1. Natacha Rosa; Sofia Leite; Juliana Alves; Angela Carvalho; Diana Oliveira; Flavia Santos; Barbara Macedo; Hugo Prazeres. "Knowledge Innovation Ecosystem for the Promotion of User-Centre Health Innovations: Living Lab Methodology and Lessons Learned Through the Proposal of Standard Good Practices". 2024. https://doi.org/10.1101/2024.01.17.573578.
    10.1101/2024.01.17.573578
Thesis / Dissertation
  1. A. Carvalho. "Microfabricated surfaces for guided tissue regeneration". PhD, Universidade do Porto Faculdade de Engenharia, 2018.
  2. A. Carvalho. "Development of nanostructured and bioactive surfaces onto ceramic substrates". Master, Universidade do Porto Faculdade de Engenharia, 2011.

Intellectual property

Provisional application for patent
  1. 2024. "Methods for the isolation, detection, and characterization of circulating tumor cells (CTCs) in biological samples and analysis of CTCs protein biomarkers relevant to lung cancer diagnosis, prognosis, treatment and minimal residual disease detection".
    Disclosed
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/11 BEAT Therapeutics, Redefining cancer treatment EIT Health InnoStars Grandfinal
EIT Health (Milan, Italy)
2023/10 Urine-derived EVs: A promising source of non-invasive biomarkers for Bladder cancer. P.CCC Raquel Seruca Immuno-Oncology Club
(Porto, Portugal)
2021/09/24 A microfluidics platform for combined analysis of two biomarkers in lung cancer: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) 3º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO)
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2021/09 A lab-on-a-chip approach for lung cancer assessment: Size-based enrichment of circulating tumour cells (CTCs) combined with circulating cell-free DNA (cfDNA) methylation analysis 31st Conference of the European Society for Biomaterials (ESB)
European Society for Biomaterials (Portugal)
2020/12 Topographical control of hMSCs differentiation: micropatterning and femtosecond laser based strategies for surface modification of hard ceramics 11th World Biomaterials Congress (WBC2020)
International Union of Societies for Biomaterials Science and Engineering
2020/11/11 A femtosecond laser-based strategy to modulate the race for the surface: micro/nanostructured ceramics surfaces to improve osteogenic differentiation and diminish bacterial adhesion 1st Surface Engineering for Biomedical Applications Workshop (SEBA)
2019/05/31 Assessing cell motility on line and pillar microengineered surfaces: An automatic tool to detect and track cells in brightfield microscopy TERMIS - EU
TERMIS (Rhodes, Greece)
2018/12/17 Biocerâmicos com superfícies microfabricadas para regeneração óssea. Jornadas de Engenharia Biomédica ISEP
(Porto, Portugal)
2018/10/16 Micropatterning zirconia and ATZ based surfaces to improve bone tissue cells V Congresso Hispano-Luso de Cerámica y Vidrio e LVI Congreso Nacional de la SECV
(Barcelona, Spain)
2018/02/11 Improving the biological response to bioinert materials: a topographical solution III Jornadas de Bioengenharia, Universidade de Trás-os-Montes e Alto Douro
2017/11/08 Improving the biological response to bioinert ceramics: a topographical solution Young Scientists Seminars
Instuto de Investigação e Inovação em Saúde (Porto, Portugal)
2017/08/10 Biological response to femtosecond laser patterned Alumina toughened Zirconia: An evaluation of osteoblasts and Staphylococcus aureus NEWGEN Workshop
COST ACTION MP1301 (Viena, Austria)
2016/05/14 Human bone marrow derived mesenchymal stem cells modulation by micro/nanostructured ATZ surfaces treated with femtosecond laser 10th World Biomaterials Congress
(Montreal, Canada)
2014/06/22 Micropatterning zirconia surfaces to improve contact with bone cells XIII Congreso Nacional de Materiales
(Barcelona, Spain)
2013/09/16 Cells and bacteria behaviour on micropatterned isotropic and anisotropic bioactive surfaces 4th International Symposium on Surfaces and Interfaces for Biomaterials
(Roma, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/10 - Current Targeting pancreatic cancer with a first-in-class inhibitor of DNA damage repair: seeking for optimized derivatives
Co-supervisor
2021/10 - Current A microfluidic assisted technology for non-invasive identification and characterization of plasma extracellular vesicles in bladder cancer patients.
Co-supervisor of Catarina Lourenço
 Doctoral Degree in Biomedical Sciences (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - 2024/07 Assessing the Therapeutic Potential of BBIT20 in Pancreatic Cancer: An In Vivo Study Using Organoids and Orthotopic Models
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2023/09 - 2024/07 Analysis of BBIT20 interactions in 3D models of different aggressive cancers
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2021/02 - 2022/09 A microfluidics approach for minimally invasive isolation and protein profiling of CTCs in lung cancer
Supervisor of João Pereira
 Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/02/09 - 2021/07/23 A microfluidic chip for size-based isolation, detection and characterization of circulating tumour cells in lung cancer
Supervisor of Mariana Fernandes
 Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/02/16 - 2021/03/03 Downstream methylation analysis of cell-free DNA (cfDNA) from lung cancer patients’ plasma following a microfluidic-assisted filtration
Supervisor of Duarte Seixas
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/10/02 - 2020/10 Characterization of circulating tumor cells (CTCs) isolated on a microfluidic chip
Supervisor of Gabriela Ferreira
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2018/02/01 - 2018/07/31 Desenvolvimento de plataformas de microfluidos para avaliar a adesão bacteriana em materiais microestruturados
Supervisor of Liliana Pinto
 Biotecnologia Medicinal (Degree)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06 - Current Workshop em internacionalização em saúde: Os mercados Portugal e Brasil (2023/06/26)
Workshop (Co-organisor)
 RESOLVE Health Program, Portugal
2023/05/25 - Current Worldwide Accelerators Rally at Matosinhos (WARM) (2023/05/25 - 2023/05/25)
Congress (Co-organisor)
 RESOLVE Health Program, Portugal
2017/06 - 2017/06 Organizing committee member of the Symposium on Biomedical Engineering in the 2nd Doctoral Congress in Engineering (DCE). (2017/06/08 - 2017/06/09)
Symposium (Member of the Scientific Committee)
 Universidade do Porto Faculdade de Engenharia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/03 - 2024/03 BIO-Europe: Industry partnering event
Congress
 BIO-Europe Spring
EBD Group , United Kingdom
2021/06/29 - 2021/06/29 Session chair: "Engineering tissue and organs - Novel biomaterials and cutting edge technology". Symposium on Biomedical Engineering - 4th Doctoral Congress Engineering (DCE21).
Congress
 4th Doctoral Congress Engineering (DCE21)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/12/18 - 2020/12/18 First Workshop of the Portuguese Network on Extracellular Vesicles: EVs in Health and Disease
Workshop
 First Workshop of the Portuguese Network on Extracellular Vesicles: EVs in Health and Disease
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/10/30 - 2020/10/30 Annual Congress Liquid Biopsy (ISLB2020)
Conference
 Annual Congress Liquid Biopsy (ISLB2020)
International Society of Liquid Biopsy, Spain
2020 - 2020 Activity "Porto for Children - Once upon a time...the bone", in which researchers go to primary schools to develop experiments with children concerning bone and skeletal development.
Instituto Nacional de Engenharia Biomédica, Portugal
2018/09 - 2018/09 Session co-chair “Advances in soft tissue engineering” - 29th European Conference on Biomaterials
Conference
 29th European Conference on Biomaterials (ESB)
European Society for Biomaterials, France
2018/07/26 - 2018/07/28 In situ Methods in Cell Biology & Cellular Biophysics
Workshop
 In situ Methods in Cell Biology & Cellular Biophysics
European Molecular Biology Organization, Germany
2014 - 2016 Mostra UP - Mostra de Ensino, Ciência e Inovação da Universidade do Porto
Universidade do Porto, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/09 Magnetic Particles for Cancer Therapy: Collection and Elimination of Circulating Tumor Cells
(Thesis) Main arguer
 Rui Silva (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/11 Preparation and characterisation of kefiran, a promising natural polymer for biomedical applications
(Thesis) Main arguer
 Maria Menezes (Master)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2022/09 Biocomposite Putty for Posterolateral Lumbar Fusion
(Thesis) Main arguer
 Lisa Salgueiro (Other)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2022/07/20 Development of Antimicrobial Hydrogel Containing Copper Oxide
(Thesis) Main arguer
 Tomás Pinheiro (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2020/07/13 PanCancer: Early detection of the four major cancers by a DNA methylation-based test in liquid biopsies
(Thesis) Main arguer
 Tiago Brito da Rocha (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/02/13 Role of SPARC derived peptides on endothelial/prostate cancer cells monoculture and co-culture models
(Thesis) Main arguer
 Francisca Seabra (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/07/11 Role of SPARC’S peptide 2.3 on endothelial and prostate cancer cells
(Thesis) Main arguer
 Helena Isabel de Freitas Branco (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2019/06/27 Thermo-responsive Magnetic Hydroxyapatite Nanoparticles Composites as Theranostics for Triple Negative Breast Cancer
(Thesis) Main arguer
 Tiago José Gil Pousa Ribeiro (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Association member

Society Organization name Role
2021/02 - Current European Association for Cancer Research (EACR) Member
2020/12 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member
2020 - Current European Society for Biomaterials Member
2019/04 - Current International Association for the Study of Lung Cancer (IASLC) Member
2019 - Current Tissue Engineering and Regenerative Medicine International Society (TERMIS) Member

Committee member

Activity description
Role 		Institution / Organization
2022/03 - 2022/03 Consensus Panel: Accelerating the Development and Validation of Early Cancer Screening & Liquid Biopsy Technologies.
Advisor / Consultant
 European Alliance for Personalized Medicine , Belgium
2019 - 2021 i3S Fundraising team
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde FUNDRAISING , Portugal

Conference scientific committee

Conference name Conference host
2021/08 - 2021/10 4th PhDay Instuto de Investigação e Inovação em Saúde
2021/04 - 2021/09 31st Conference of the European Society For Biomaterials (ESB 2021) European Society for Biomaterials
2021/06/28 - 2021/06/29 Symposium on Biomedical Engineering - 4th Doctoral Congress Engineering (DCE21) Universidade do Porto, Faculdade de Engenharia
2020/12 - 2020/12 11th World Biomaterials Congress (WBC2020) International Union of Societies for Biomaterials Science and Engineering
2017/06/08 - 2017/06/09 Symposium on Biomedical Engineering - 2nd Doctoral Congress in Engineering (DCE) Universidade do Porto Faculdade de Engenharia

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/11 - 2024/11 Seminars in Biomedical Engineering. "Science & Entrepreneurship: The translation from the lab to the market" Biomedical Engineering Universidade do Porto Faculdade de Engenharia, Portugal
2023/10/22 - 2023/10/22 Seminars in Biomedical Engineering. "Science & Entrepreneurship: The translation from the lab to the market" Bioengenharia (Mestrado integrado) Universidade do Porto Faculdade de Engenharia, Portugal
2021/12 - 2021/12 Invited Lecturer - Seminars in Biomedical Engineering "Liquid biopsies for cancer management: Microfluidics-assisted liquid biopsies" Biomedical Engineering (Doutoramento) Universidade do Porto Faculdade de Engenharia, Portugal
2018/10 - 2018/10 Invited Lecturer - Seminars in Biomedical Engineering Engenharia Biomédica (Doutoramento) Universidade do Porto Faculdade de Engenharia, Portugal
2016/03 - 2016/03 Workshop "Biomaterials" - IV AEICBAS Biomedical Congress Bioengenharia (Mestrado integrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/01 Podcast "Futuro do Futuro" Expresso
2017/07 Project HECOLCAP has been highlighted in news agencies such as TVI24, Observador and Diário de Notícias.

Journal scientific committee

Journal title (ISSN) Publisher
2021/04 - Current Journal of Functional Biomaterials (Topic Editor) MDPI
2013/02 - Current Advances in Materials Science and Applications (2306-9317) The World Academic Publishing
2021/12 - 2022/01 ACS Applied Materials & Interfaces ACS
2021/07 - 2021/07 Industrial & Engineering Chemistry Research Elsevier
2021/06 - 2021/07 Molecules MDPI
2021/06 - 2021/06 British Journal of Cancer Nature
2021/06 - 2021/06 Materials Letters Elsevier
2021/01 - 2021/02 Materials Science & Engineering C (0928-4931) Elsevier
2020/12 - 2020/12 International Journal of Dentistry Hindawi
2018/07 - 2018/08 Acta Biomaterialia (1742-7061) Elsevier
2018/06 - 2018/07 Dental Materials (0109-5641) Elsevier
2016/09 - 2016/10 Biomacromolecules (1526-4602) American Chemical Society
2013/02 - 2013/03 Materials Research (1980-5373) SciELO

Mentoring / Tutoring

Topic Student name
2019/09 - 2020/02 Biological response to Collagen/Chitosan/Silk Fibroin Scaffolds Sylwia Grabska-Zielinska
2017/01 - 2017/03 nano-ß-TCP and nano-HA biological assessment Arkaitz Ruiz
2016/09 - 2016/10 Characterization methods for gelatin and chitosan scaffolds Beata Kaczmarek
2015/09 - 2016/03 Surface modification of 3Y-TZP with microstructured silica coatings Ranulfo Miranda
2013/01 - 2013/07 Development of Silica and Silica-Nanohydroxyapatite thin films Mariline Pinto
2013/01 - 2013/07 Microfabrication techniques for the surface modification of Zirconia ceramics Úrsula Pereira
2012/11 - 2012/11 Development of silica coatings by sol-gel Bruno Oliveira
2011/02 - 2011/07 Microfabrication techniques to develop a microfluidic system Rita Sousa

Other jury / evaluation

Activity description Institution / Organization
2019/06 - 2019/07 Jury member for a Research Fellowship (MSc) Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/06 - 2018/08 Jury member for a contract position (PhD) Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Distinctions

Award

2024 Prémio Jovem Empreendedor 2023
ANJE Associação Nacional de Jovens Empresários, Portugal
2024 Women TechEU
European Innovation Council, Belgium
2023 Winner iUP25k - Concurso de ideias de negócio da Universidade do Porto (BEAT Therapeutics)
Universidade do Porto, Portugal
2023 Winner Startup Olé pitch competition (Bio/pharma tech) - BEAT Therapeutics
Startup Olé , Spain
2023 2nd place - EIT Health InnoStars Grandfinal (BEAT Therapeutics)
EIT Health, Germany
2021 Best e-poster communication (Engineering topic) - IJUP21
Universidade do Porto, Portugal
2019 i3S Fundraising Cancer Short-term fellowship by Quinta do Estanho
Universidade do Porto Instituto de Investigação e Inovação em Saúde FUNDRAISING , Portugal
2019 2º Prize Hovione Health Capital Innovation Award
Agência Nacional de Inovação SA, Portugal
2019 EIT Health and Aescuvest award at the Hovione Health Capital Innovation
EIT Health, Germany

Aescuvest, Germany
2019 Patentree award at the Hovione Health Capital Innovation
Patentree, Portugal
2019 BfK award (Born from Knowledge )
Agência Nacional de Inovação SA, Portugal
2018 Best Business Case
RESOLVE Health Program, Portugal
2017 Travel Grant - NEWGEN: Patient-specific bone tissue engineering - An ambitious goal requiring a "holistic" approach
European Cooperation in Science and Technology, Belgium
2016 Short Term Scientific Mission grant
European Cooperation in Science and Technology, Belgium
2015 Best Poster Award
Department of Electrical and Computer Engineering (DEEC) Faculdade de Engenharia da Universiade do Porto, Portugal

Other distinction

2019 Cum Laude (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2012 Individual PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal