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Marisol Gouveia (MG) holds a BSc in Biochemistry (2010) and an MSc in Applied Biochemistry (2014) from the University of Madeira, Portugal. In 2023, she completed a PhD in Biomedicine at the University of Aveiro. Her multidisciplinary background covers medicinal chemistry, proteomics, exercise physiology, and translational cardiovascular research. MG’s early research focused on the synthesis and in vitro evaluation of organometallic compounds with anticancer potential. Her PhD work marked a transition to cardiovascular health, specifically analyzing extracellular proteostasis in patients with heart failure (HF). In this context, she investigated how exercise training impacts protein aggregation to identify novel therapeutic targets for HF. She secured funding as Principal Investigator under the European Proteomics Infrastructure Consortium (EPIC-XS) to explore the role of exosomes in mediating the benefits of exercise in HF patients. MG published 15 peer-reviewed articles, 1 book chapter, and participated in several scientific communications. She is also dedicated to mentorship, having supervised Master’s and PhD candidates in laboratory procedures and clinical sample handling. Committed to sientific communication, she actively participates in outreach initiatives organized by the Madeira Chemistry Research Centre (CQM), including “Chemistry is Fun” and “Science Shop”. Furthermore, she coordinated hands-on science programs for the Portuguese Red Cross, including the CIGA/GIRO project for social inclusion in Roma communities and extracurricular enrichment at Prado Elementary School.
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Identification

Personal identification

Full name
Marisol Gouveia

Citation names

  • Gouveia, Marisol

Author identifiers

Ciência ID
DA1E-8B8A-A941
ORCID iD
0000-0002-6489-5283

Email addresses

  • marisolgouveia@ua.pt (Professional)
  • marisolgouveia5@gmail.com (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems
  • Medical and Health Sciences - Health Sciences - Sport and Fitness Sciences
Education
Degree Classification
2023/03/30
Concluded
 Biomedicina (Doutoramento)
Universidade de Aveiro, Portugal
"Analysis of extracellular proteostasis and exercise training in patients with heart failure" (THESIS/DISSERTATION)
 Approved by unanimity
2014
Concluded
 Bioquímica Aplicada (Mestrado)
Major in Sem especialização
Universidade da Madeira, Portugal
"Metalodendrímeros de baixa geração utilizando dendrímeros poli(alquilideno imina) funcionalizados com nitrilos: estudos de citotoxicidade." (THESIS/DISSERTATION)
 18 valores
2010
Concluded
 Bioquímica (Licenciatura)
Universidade da Madeira, Portugal
"n/a" (THESIS/DISSERTATION)
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2016/05/01 - 2017/08/31 Researcher (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro, Portugal
2011/02/01 - 2011/09/30 Researcher (Research) Universidade da Madeira Centro de Química da Madeira, Portugal
Universidade da Madeira, Portugal

Others

Category
Host institution 		Employer
2024/09 - Current Teacher of Visual Programming Algorithmics Santo Tirso , Portugal
2024/07 - 2025/03 Arts and Hands-on Science Instructor Cruz Vermelha Portuguesa, Portugal
2017/10/01 - 2023/03/30 PhD Student Universidade de Aveiro Instituto de Biomedicina, Portugal
Universidade de Aveiro, Portugal
Projects

Contract

Designation Funders
2020 - Current Are Exosomes Mediating the Positive Effects of Exercise Training in Patients with Heart Failure?
EPIC-XS-0000219
Principal investigator
Ongoing
2021 - 2022/05/31 Clinical and Economic Impact of a Clinic-based versus Home-based Exercise Intervention in Heart Failure with Preserved Ejection Fraction: A Pragmatic Clinical Trial
PTDC/MEC-CAR/30011/2017
Researcher
Universidade do Porto, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
2017/07/01 - 2018/07/31 pAGE: Protein aggregation across the lifespan
CENTRO-01-0145-FEDER-000003
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Teixeira, Manuel; Martins, Tânia Soares; Gouveia, Marisol; Henriques, Ana Gabriela; Santos, Mário; Ribeiro, Fernando. "Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular Disease". In Extracellular Vesicles in Cardiovascular and Metabolic Diseases, 241-258. Springer Nature Singapore, 2023.
    10.1007/978-981-99-1443-2_16
Conference abstract
  1. Gouveia, Marisol; Soares Martins, T; Schmidt, Cristine; Gois, Priscilla; Teixeira, Manuel; Munoz, Xavier; Embun, Pillar Ximenez; et al. "Exercise Training Improves the exosomal content in patients with heart failure. Conference abstract published on Journal of the American College of Cardiology". Paper presented in 2022 American College of Cardiology, Washington, 2022.
    Published
  2. Gouveia, Marisol; Teixeira, Manuel ; Schmidt, Cristine ; Magalhães, Sandra; Nunes, Alexandra ; Santos, Mário ; Vieira, Sandra ; Ribeiro, Fernando. "Exercise training increases toxic protein oligomers uptake function of peripheral blood mononuclear cells in patients with heart failure". Paper presented in American College of Cardiology’s 71st Annual Scientific Meeting, 2022.
    Published • 10.1016/s0735-1097(22)02433-0
  3. Gouveia, Marisol; Martins, Tânia ; Schmidt, Cristine; Gois, Priscilla ; Teixeira, Manuel; Muñoz, Xavier; Ximénez-Embún, Pilar ; et al. "Exercise training improves the exosomal content in patients with heart failure". Paper presented in American College of Cardiology's 71st Annual Scientific Meeting, 2022.
    Published • 10.1016/s0735-1097(22)02582-7
  4. Gouveia, Marisol; Schmidt, Cristine; Teixeira, Manuel; Magalhaes, Sandra ; Nunes, Alexandra ; Lopes, Mário; Vitorino, Rui; et al. "Effect of exercise training on amyloid-like protein aggregates among patients with heart failure". Paper presented in ESC Preventive Cardiology, 2021.
    Published • 10.1093/eurjpc/zwab061.038
  5. Teixeira, Manuel; Lima, Suiane; Gouveia, Marisol; Duarte, Ana; Ferreira, Miriam; Simões, Maria I; Conceição, Maria; et al. "Acute exercise changes the fourier-transform infrared spectra profile in individuals with hypertension and other cardiovascular risk factors: effect of the session duration". Paper presented in ESH-ISH Joint Meeting, 2021.
    10.1097/01.hjh.0000748768.29955.24
  6. Gouveia, Marisol; Schmidt, Cristine; Teixeira, Manuel; Magalhães, Sandra; Nunes, Alexandra; Lopes, Mário; Ferreira, Rita; et al. "Analysis of plasma protein aggregation from patients with heart failure with preserved ejection fraction". Paper presented in ESH-ISH Joint Meeting, 2021.
    Published • 10.1097/01.hjh.0000745440.17152.fc
  7. Lopes, Susana; Afreixo, Vera; Teixeira, Manuel; Garcia, Catarina; Leitão, Cátia; Gouveia, Marisol; Figueiredo, Daniela; et al. "Effects of exercise training on arterial stiffness in patients with hypertension: a systematic review and meta-analysis". Paper presented in ESH-ISH Joint Meeting, 2021.
    Published • 10.1097/01.hjh.0000748836.49509.75
  8. Gouveia, Marisol.; Cavalcante, Suiane; Viamonte, Sofia ; Santos, Mãrio; Vieira, Sandra; Ribeiro, Fernando. "Analysis of protein aggregates in plasma of heart failure patients: a case series". 2018.
    Published
Conference poster
  1. Teixeira, Manuel; Nogueira-Ferreira, Rita; Oliveira, Maria Isilda; Gouveia, Marisol; Ferreira, Rita; Santos, Mário; Ribeiro, Fernando. "Extracellular vesicles proteomic profile of patients with idiopathic pulmonary arterial hypertension". Paper presented in VI iBiMED symposium, 2023.
  2. Gouveia, Marisol; Schmidt, Cristine; Teixeira, Manuel; Lopes, Mário; Aveiro, Susana; Domingues, Pedro; Xia, Ke; et al. "Increased levels of circulating SDS-resistant protein aggregates in patients with heart failure with preserved ejection fraction". Paper presented in Heart Failure & World Congress on Acute Heart Failure, 2022.
  3. Gouveia, Marisol; Teixeira, Manuel; Schmidt, Cristine; Magalhães, Sandra; Nunes, Alexandra; Santos, Mário; Vieira, Sandra Isabel ; Ribeiro, Fernando. "Exercise training increases toxic protein oligomers uptake function of peripheral blood mononuclear cells in patients with heart failure". Paper presented in American College of Cardiology’s 71st Annual Scientific Meeting, 2022.
  4. Gouveia, Marisol; Martins, Tânia; Schmidt, Cristine; Gois, Priscilla; Teixeira, Manuel; Muñoz, Xavier; Ximénez-Embún, Pilar; et al. "Exercise training improves the exosomal content in patients with heart failure". Paper presented in American College of Cardiology’s 71st Annual Scientific Meeting, 2022.
    10.1016/s0735-1097(22)02582-7
  5. Gouveia, Marisol; Schmidt, Cristine; Teixeira, Manuel; Magalhães, Sandra; Nunes, Alexandra; Lopes, Mário; Vitorino, Rui; et al. "Effect of exercise training on amyloid-like protein aggregates among patients with heart failure". Paper presented in ESC Preventive Cardiology, 2021.
    10.1093/eurjpc/zwab061.038
  6. Gouveia, Marisol; Schmidt, Cristine; Teixeira, Manuel; Magalhães, Sandra; Nunes, Alexandra; Lopes, Mário; Ferreira, Rita; et al. "Analysis of plasma protein aggregation from patients with heart failure with preserved ejection fraction". Paper presented in ESH-ISH Joint Meeting, 2021.
    10.1097/01.hjh.0000745440.17152.fc
  7. Teixeira, Manuel; Lima, Suiane; Gouveia, Marisol; Duarte, Ana; Ferreira, Miriam; Simões, Maria I.; Conceição, Maria; et al. "Acute exercise changes the fourier-transform infrared spectra profile in individuals with hypertension and other cardiovascular risk factors: effect of the session duration". Paper presented in ESH-ISH Joint Meeting, 2021.
    10.1097/01.hjh.0000748768.29955.24
  8. Lima, Suiane; Gouveia, Marisol; Ribeiro, Ilda; Gonçalves, Ana Cristina; Venâncio, João; Santos, Mário; Viamonte, Sofia; Oliveira, José; Ribeiro, Fernando. "Effects of maximal exercise on the circulating number of endothelial progenitor cells in patients with heart failure". Paper presented in EuroPrevent, 2019.
  9. Teixeira, Manuel; Gouveia, Marisol; Duarte, Ana; Ferreira, Miriam; Simões, Maria; Conceição, Maria; Silva, G; et al. "Proteostasis, inflammatory and vasoactive biomarkers in patients with hypertension: effect of exercise training". Paper presented in EuroPrevent, 2019.
  10. Gouveia, Marisol; Cavalcante, Suiane; Teixeira, Manuel; Viamonte, Sofia; Santos, Mário; Vieira, Sandra Isabel ; Ribeiro, Fernando. "Analysis of protein aggregates in patients with heart failure and hypertension by diagonal 2D SDS-PAGE". Paper presented in IV Postgraduation Symposium in Biomedicine, 2018.
  11. Gouveia, Marisol; Cavalcante, Suiane; Viamonte, Sofia; Santos, Mário; Vieira, Sandra Isabel ; Ribeiro, Fernando. "Analysis of protein aggregates in plasma of heart failure patients: a case series". Paper presented in CIMAGO Scientific Meeting, 2018.
Journal article
  1. Schmidt, Cristine; Magalhães, Sandra; Gois Basilio, Priscilla; Gouveia, Marisol; Teixeira, Manuel; Santos, Cláudio; Tavares, Aida Isabel; et al. "Home- versus centre-based EXercise InTervention in patients with Heart Failure (EXIT-HF trial): A pragmatic randomized controlled trial". Revista Portuguesa de Cardiologia 43 3 (2024): 149-158. https://doi.org/10.1016/j.repc.2023.05.013.
    10.1016/j.repc.2023.05.013
  2. Gouveia, Marisol; Schmidt, Cristine; Basilio, Priscilla Gois; Aveiro, Susana S.; Domingues, Pedro; Xia, Ke; Colón, Wilfredo; et al. "Exercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction". Molecular and Cellular Biochemistry 479 10 (2023): 2711-2722. https://doi.org/10.1007/s11010-023-04884-z.
    10.1007/s11010-023-04884-z
  3. Suiane Cavalcante; Manuel Teixeira; Marisol Gouveia; Ana Duarte; Miriam Ferreira; Maria I. Simões; Maria Conceição; et al. "Reaktion der endothelialen Progenitorzellen auf ein Multikomponenten-Trainingsprogramm bei Erwachsenen mit kardiovaskulären Risikofaktoren". German Journal of Exercise and Sport Research 53 2 (2023): 225-231. https://doi.org/10.1007%2Fs12662-023-00882-x.
    10.1007/s12662-023-00882-x
  4. Gouveia, M.; Teixeira, M.; Schmidt, C.; Lopes, M.; Trindade, D.; Magalhães, S.; Henriques, A.G.; et al. "Impaired Extracellular Proteostasis in Patients with Heart Failure". Archives of Medical Research (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85147874226&partnerID=MN8TOARS.
    10.1016/j.arcmed.2023.02.001
  5. Cavalcante, S.; Viamonte, S.; Cadilha, R.S.; Ribeiro, I.P.; Gonçalves, A.C.; Sousa-Venâncio, J.; Gouveia, M.; et al. "Maximal Exercise Improves the Levels of Endothelial Progenitor Cells in Heart Failure Patients". Current Issues in Molecular Biology 45 3 (2023): 1950-1960. http://www.scopus.com/inward/record.url?eid=2-s2.0-85151145704&partnerID=MN8TOARS.
    10.3390/cimb45030125
  6. Teixeira, Manuel ; Trindade, Dário; Gouveia, Marisol; Eller-Borges, Roberta; Magalhães, Sandra; Duarte, Ana; Ferreira, Miriam; et al. "Proteostasis Response to Protein Misfolding in Controlled Hypertension". Cells 11 10 (2022): 1686-1686. http://dx.doi.org/10.3390/cells11101686.
    10.3390/cells11101686
  7. Lopes, J.; Teixeira, M.; Cavalcante, S.; Gouveia, M.; Duarte, A.; Ferreira, M.; Simões, M.I.; et al. "Reduced Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Heart Failure with Reduced Ejection Fraction". Archives of Medical Research 53 3 (2022): 289-295. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124710266&partnerID=MN8TOARS.
    10.1016/j.arcmed.2022.02.001
  8. Gouveia, M.; Schmidt, C.; Teixeira, M.; Lopes, M.; Aveiro, S.S.; Domingues, P.; Xia, K.; et al. "Characterization of Plasma SDS-Protein Aggregation Profile of Patients with Heart Failure with Preserved Ejection Fraction". Journal of Cardiovascular Translational Research (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140354805&partnerID=MN8TOARS.
    10.1007/s12265-022-10334-w
  9. Magalhães, Sandra; Teixeira, Manuel; Gouveia, Marisol; Ribeiro, Fernando; Goodfellow, Brian; Nunes, Alexandra. "FTIR spectroscopy confirms age-related changes in protein conformation in a new independent dataset of human plasma samples". Medical Research Archives 10 2 (2022): http://dx.doi.org/10.18103/mra.v10i2.2616.
    10.18103/mra.v10i2.2616
  10. Lopes, S.; Afreixo, V.; Teixeira, M.; Garcia, C.; Leitao, C.; Gouveia, M.; Figueiredo, D.; et al. "Exercise training reduces arterial stiffness in adults with hypertension: A systematic reviewand meta-analysis". Journal of Hypertension 39 2 (2021): 214-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099322090&partnerID=MN8TOARS.
    10.1097/HJH.0000000000002619
  11. Teixeira, M.; Gouveia, M.; Duarte, A.; Ferreira, M.; Simões, M.I.; Conceição, M.; Silva, G.; et al. "Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients With Hypertension". American journal of hypertension 33 2 (2020): 119-123. http://www.scopus.com/inward/record.url?eid=2-s2.0-85080849442&partnerID=MN8TOARS.
    10.1093/ajh/hpz160
  12. Gomes, C.; Ferreira, D.; Carvalho, J.P.F.; Barreto, C.A.V.; Fernandes, J.; Gouveia, M.; Ribeiro, F.; Duque, A.S.; Vieira, S.I.. "Current genetic engineering strategies for the production of antihypertensive ACEI peptides". Biotechnology and Bioengineering 117 8 (2020): 2610-2628. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085880246&partnerID=MN8TOARS.
    10.1002/bit.27373
  13. Gouveia, M.; Figueira, J.; Jardim, M.G.; Castro, R.; Tomás, H.; Rissanen, K.; Rodrigues, J.. "Poly(alkylidenimine) dendrimers functionalized with the organometallicmoiety [Ru(¿5-C5H5)(PPh3)2]+ as promising drugs against cisplatin-resistant cancer cells and human mesenchymal stem cells". Molecules 23 6 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048942843&partnerID=MN8TOARS.
    10.3390/molecules23061471
  14. Gouveia, M.; Xia, K.; Colón, W.; Vieira, S.I.; Ribeiro, F.. "Protein aggregation, cardiovascular diseases, and exercise training: Where do we stand?". Ageing Research Reviews 40 (2017): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026838828&partnerID=MN8TOARS.
    10.1016/j.arr.2017.07.005
  15. Rodrigues, João; Jardim, Manuel G.; Figueira, João; Gouveia, Marisol; Tomás, Helena; Rissanen, Kari; Rodrigues, J.; et al. "Poly(alkylidenamines) dendrimers as scaffolds for the preparation of low-generation ruthenium based metallodendrimers". New Journal of Chemistry 35 10 (2011): 1938-1943. http://hdl.handle.net/10400.13/2403.
    10.1039/c1nj20364a
Thesis / Dissertation
  1. "Analysis of extracellular proteostasis and exercise training in patients with heart failure". PhD, 2023. http://hdl.handle.net/10773/38280.
  2. Gouveia, Marisol Fátima Sánchez de. "Metalodendrímeros de baixa geração utilizando dendrímeros poli(alquilideno imina) funionalizados com nitrilos: estudos de citotoxicidade". Master, 2014. http://hdl.handle.net/10400.13/1182.

Other

Dataset
  1. Gouveia, Marisol; Schmidt, Cristine; Basilio, Priscilla Gois; Susana Seabra Aveiro ; Domingues, Pedro; Ke Xia; Wilfredo Colón; et al. Proteomics Data available via ProteomeXchange. "Exercise training decreases the load and changes the content of circulating SDS-resistant protein aggregates in patients with heart failure with reduced ejection fraction". https://www.ebi.ac.uk/pride/archive/projects/PXD045161. 2025.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/07 Analysis of protein aggregation in plasma of patients with heart failure with preserved ejection fraction Research summit UA
University of Aveiro (Aveiro, Portugal)
2020/06 Analysis of protein aggregation in plasma of patients with heart failure with preserved ejection fraction Research summit UA
University of Aveiro (Aveiro, Portugal)
2019/06 Analysis of protein aggregation in plasma of patients with heart failure with preserved ejection fraction Research summit UA
University of Aveiro (Aveiro, Portugal)
2016/02 The Need for a New Approach to Fight Cancer - The use of metallodendrimers as anticancer drug Indo-Portuguese Workshop On Emerging Trends Of Nanotechnology In Chemistry And Biology (INCB2016)
(Nova Deli, India)
2015/05 A short overview on the use of metallodendrimers to fight cancer and other diseases – a case study
Huazhong Agricultural University (Wuhan, China)
2015/03 Insights on the use of metallodendrimers to fight cancer and other diseases Nanotech Dubai 2015
(Dubai, United Arab Emirates)
2014/11 Metallodendrimers as a tool against old and emerging diseases: basic principles IV Escuela de Nanomedicinas
(CABA, Argentina)
2014/01 Low-generation metallodendrimers using nitrile-functionalized poly(alkylidenimines) dendrimers: Cytotoxicity studies
Madeira University (Funchal, Portugal)
2013/01 Preparation of low-generation metallodendrimers using nitrile-functionalized poly(alkylidenamines) dendrimers: cytotoxicity studies in cancer cell lines 8th Materials Group Meeting/CQM
(Funchal, Portugal)
2012/09 Ruthenium Poly(alkylidenamine) Nitrile Dendrimers - A New Family of Biometallodendrimers XXV International Conference on Organometallic Chemistry (XXV ICOMC)
(Lisboa, Portugal)
2012/09 Low-generation ruthenium based metallodendrimers for biomedical applications Biodendrimer
(Toledo, Spain)
2012/01 Preparation of low-generation metallodendrimers using nitrile-functionalized poly(alkylidenamines) dendrimers: cytotoxicity studies in cancer cell lines 7th Materials Group Meeting/CQM
(Funchal, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/07 - 2025/03 Designed and implemented hands-on science and art activities for children and teenagers at the Red Cross and Prado Basic School. (2024 - 2025)
2011/09/07 - 2011/09/10 Member of the Organizing Committee for the 8th Supraphone Meeting, promoted by the Madeira Research Centre (CQM) (2011/09/07 - 2011/09/10)
Congress
Distinctions

Other distinction

2017 PhD grant SFRH/BD/128893/2017
Fundação para a Ciência e a Tecnologia, Portugal