Maria Rosário Almeida (D91F-F83F-A3FD)

Curriculum Vitae

Maria Rosário Almeida

Maria Rosário Almeida graduated in Biochemistry in 1986 by Faculdade de Ciências (FCUP) and Instituto de Ciências Biomédicas de Abel Salazar (ICBAS) at Universidade do Porto (UP). Entered the academic career and, in parallel, developed a PhD in Biomedical Sciences that was concluded in 1995 at ICBAS, UP. Currently, is Associate Professor of Biochemistry at ICBAS, and Principal Researcher at the i3S- Instituto de Investigação e Inovação em Saúde (i3S), UP. At ICBAS, she is a member of the Molecular Biology department and is responsible and co-responsible for curricular units (UCs) in the area of structural and metabolic biochemistry and, in particular, protein structure and function for the gradiuation and master courses of Biochemistry and Bioengineering. She also collaborates in teaching at other courses. She has been Director/Co-Director of the graduation course in Biochemistry from 2012 to 2021. She has been Member of the Pedagogical Council and from 2010 to 2018 she has been Member of the ICBAS Representative Committee. Her research focuses mainly on the study of transthyretin (TTR) amyloidosis having developed her doctoral project at ICBAS. She continued her scientific work at the Institute of Molecular and Cellular Biology (IBMC) and is currently a senior researcher in the Biomolecular Structure and Function Group at I3S - Institute for Research and Innovation in Health. The work she develops aims to elucidate molecular mechanisms and pathophysiology of TTR amyloidosis and modulators of TTR aggregation and fibril formation using in vitro, cell culture studies and mice expressing hTTR variants holding the ultimate purpose of uncovering new biomarkers or drug targets. Recently, she investigates the involvement of proteolysis in TTR aggregation and in its pathology, particularly associated with the cardiac and ocular forms of TTR amyloidosis. She also participates in translational projects aiming the development of new therapies in amyloidosis. Throughout her career she has participated in several competitive and non-competitive funded projects as a PI or as a researcher and has supervised more than 20 undergraduate students and several master's (6) and PhD students (6) and published more than 60 articles in international scientific journals (h-index=29).

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Identification

Personal identification

Full name: Maria Rosário Almeida

Citation names

Almeida, Maria Rosario

Author identifiers

Ciência ID: D91F-F83F-A3FD
ORCID iD: 0000-0001-9289-3835

Email addresses

ralmeida@ibmc.up.pt (Professional)

Telephones

Mobile phone

917856407 (Personal)

Telephone

220428000 Ext.: 8140 (Professional)
226074900 Ext.: 6137 (Professional)

Addresses

ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Rua Jorge Viterbo Ferreira 228 , 4050-313 , Porto, Porto, Portugal (Professional)
i3S - Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208 , 4200-135 , Porto, Porto, Portugal (Professional)
Rua da Vigorosa 709, 4200-524, Porto, Porto, Portugal (Personal)

Websites

i3S.up.pt (Professional)
icbas.up.pt (Professional)

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
English	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2024/02/29 - 2024/03/01 Concluded	Ciências Biomédicas (Título de Agregado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Aprovado por unanimidade
1995/07/14 Concluded	Doutoramento em Ciências Biomédicas, Especialidade Bioquímica (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Caracterização Genética e Bioquímica de Variantes Moleculares de Transtirretina (http://hdl.handle.net/10216/10314)" (THESIS/DISSERTATION)	Aprovada com distinção, por unanimidade
1991/05/16 Concluded	Provas de Aptidão Pedagógica e Capacidade Científica (Outros) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Muito Bom (por unanimidade)
1986/10/12 Concluded	Licenciatura em Bioquimica (Licenciatura) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Ciências, Portugal "Caracterização de variantes de hemoglobina" (THESIS/DISSERTATION)	16 valores

Affiliation

Science

	Category Host institution	Employer
1997 - Current	Principal Investigator (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal (...)
1987 - 1997	Research Assistant (Research)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal (...)

Teaching in Higher Education

	Category Host institution	Employer
2024/03/01 - Current	Associate Professor (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

2006/05/01 - 2024/02/29	Associate Professor (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1995/07 - 2006/04/30	Assistant Professor (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1991/05 - 1995/07	Assistant (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1987/03 - 1991/04	Trainee Assistant (University Teacher)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Positions / Appointments

	Category Host institution	Employer
2014 - 2016	Conselho geral ou orgão correspondente	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

2014 - 2016	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

2013 - 2014	Conselho de gestão ou orgão correspondente	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Projects

Grant

	Designation	Funders
2022/01/01 - 2025/09/30	Dissecting unexplored mechanisms underlying Transthyretin neuroprotection and advancing towards a therapy for Alzheimer´s Disease PTDC/MED-PAT/0959/2021 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Centro Hospitalar e Universitário de Coimbra EPE, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024/09/01 - 2025/05/31	TinHeart - Tackling Transthyretin to combat Type I Diabetes- associated heart disease TinHeart Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Novo Nordisk Denmark A/S Ongoing
2020/10 - 2023/09	HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological and infectious diseases NORTE-01-0145-FEDER-000039 NORTE-01-0145-FEDER-000039 Researcher Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Ongoing
2016/08/16 - 2020/02/15	NEUROTERA: Introdução no mercado de novos agentes terapêuticos contra co-morbilidades oculares e cerebrais associadas à Paramiloidose POCI-01-0247-FEDER-003431 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização Concluded
2016/05/01 - 2019	NORTE-01-0145-FEDER-000008 - Porto Neurosciences and Neurologic Disease Research Initiative at I3S NORTE-01-0145-FEDER-000008 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/01/01 - 2015/06/30	NORTE-07-0124-FEDER-000001 - Neurodegenerative Disorders NORTE-07-0124-FEDER-000001 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Concluded
2014/05 - 2015/06	Diagnóstico e combate molecular de três doenças neurodegenerativas (Parkinson, Phenylketonuria and TTR amyloidosis) NEUROMED-SOE4/P1/E831 NEUROMED-SOE4/P1/E831 NEUROMED-SOE4/P1/E831 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	N/A Concluded
2011/01/01 - 2012/12/30	PEst-C/SAU/LA0002/2011 FCOMP-01-0124-FEDER-022718 - Project - LA 2 - 2011-2012 PEst-C/SAU/LA0002/2011 FCOMP-01-0124-FEDER-022718 PEst-C/SAU/LA0002/2013 FCOMP-01-0124-FEDER-037277 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Concluded
2005/07/01 - 2008/11/30	Familial Amyloidotic Polyneuropathy - a contribution for a therapeutical strategy POCI/SAU-NEU/58735/2004 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004/01 - 2006/06	Mecanismos moleculares e celulares no metabolismo de lipoproteinas e de transtirretina POCTI/BCI/49459/2002 POCTI/BCI/49459/2002 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001 - 2003	Amyloidogenesis in familial amyloid polyneuropathy: factors and prevention POCTI/CBO/35785/1999 Researcher Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
1998/09 - 2000/09	Interacções moleculares de agentes tóxicos e farmacológicos com a transtirretina: implicações no metabolismo da tiroxina e vitamina A FCT- Praxis XXI PCNA/BIA/165/96 FCT- Praxis XXI ¿ PCNA/BIA/165/96 Principal investigator Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	Institute for Research and Innovation in Health LA/P/0070/2020 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Instituto de Investigação e Inovação em Saúde LA/P/0070/2020 10.54499/LA/P/0070/2020 UID/BIM/04293/2019 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/12/01 - 2021/06/30	NEw Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine SAICTPAC/0047/2015 Researcher Universidade do Porto Faculdade de Medicina, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Universidade de Aveiro, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Institute for Research and Innovation in Health Sciences UID/BIM/04293/2019 Researcher Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/03/01 - 2014/12/31	Study of natural and synthetic inhibitors of transthyretin amyloidosis and characterization of their mechanism of action PTDC/SAU-ORG/116645/2010 Principal investigator Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2012/12/31	Strategic Project - LA 2 - 2011-2012 PEst-C/SAU/LA0002/2011 Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2005/06/01 - 2008/08/31	Search for TTR ligands modulators of amyloidogenesis POCI/SAU-MMO/57321/2004 Principal investigator Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Almeida, Maria. "A abordagem do Bioquímico - Contributos da Bioquímica para o conhecimento e desenvolvimento de terapias para a Paramiloidose". In One Health – Uma Saúde: Um Contributo da Universidade, 31-43. Porto, Portugal: Instituto de Ciências Biomédicas Abel Salazar (ICBAS), U.Porto Press, 2024. Published Almeida, Maria; Maria João Mascarenhas Saraiva. "Doenças genéticas humanas". In Engenharia Genética, Princípios e aplicações.. Portugal: LIDEL-edições técnicas Lda, 2011. Published Almeida, M.R.; Macedo, B.; Cardoso, I.; Valencia, G.; Arsequell, G.; Planas, A.; Saraiva, M.J.. "Effects of a new diflunisal derivative on transthyretin binding and stabilization in serum from FAP patients". 497-499. 2004.
Conference abstract	Bernardes, Catarina; Guerreiro, Rita; Bras, Jose; Durães, João; Baldeiras, Inês; Lima, Marisa; Almeida, Maria Rosario; Santana, Isabel; Tábuas-Pereira, Miguel. "HISTÓRIA FAMILIAR DE DOENÇA DE ALZHEIMER NUMA COORTE PORTUGUESA: EVIDÊNCIA DE RISCO ASSOCIADO AO X E ALELOS RECESSIVOS". Paper presented in 38ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, 2024. Published
Conference poster	Joana Pinho Barbosa; Gião, Tiago; Neves, João Sérgio; Nogueira-Ferreira, Rita; Trindade, Fábio; Sandra Marisa de Jesus Oliveira; Carla Luís; et al. "Assessing Transthyretin levels and stability in Type 1 Diabetes - associated heart disease". Paper presented in XXII National Congress of Biochemistry, 2024. Pinheiro F; Carla Filipa Bezerra; Maria João Saraiva; Salvador Ventura; Almeida, Maria. "'Testing optimized Tolcapone derivatives for plasma TTR stabilization aiming improved therapies in TTR amyloidosis'". Paper presented in XIX - International Symposium on Amyloidosis, 2024. Diana Valente; Durães, João; Barros, Francisco; Lima, Marisa; Baldeiras, Ines; Tábuas-Pereira, Miguel; Almeida, Maria Rosario; Isabel Santana. "DOENÇA DE ALZHEIMER DE INÍCIO PRECOCE: IMPLICAÇÕES GENÉTICAS E DESAFIOS DIAGNÓSTICOS". Paper presented in 38ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, 2024. Almeida, Maria Rosario; Isabel dos Santos Cardoso. Corresponding author: Almeida, Maria Rosario. "Study of modulators of Transthyretin (TTR) proteolysis in eye ATTR amyloidosis". Paper presented in VIII Jornadas da Bioquímica, 2022.
Journal article	Diogo Costa-Rodrigues; Maria João Saraiva; Maria Rosário Almeida; Luís Gales. "A novel approach for evaluating transthyretin kinetic stabilizers using plasma samples". Amyloid (2025): https://doi.org/10.1080/13506129.2025.2464250. 10.1080/13506129.2025.2464250 Maria Strecht Almeida; Maria Almeida. "On Research Integrity within Science Training –Writing and Resorting to Images in the Molecular Biosciences". Journal of Academic Writing 15 S1 (2025): https://publications.coventry.ac.uk/index.php/joaw/article/view/988. Costa-Rodrigues, Diogo; Leite, José P.; Saraiva, Maria João; Almeida, Maria Rosário; Gales, Luís. "Transthyretin monomers: a new plasma biomarker for pre-symptomatic transthyretin-related amyloidosis". Amyloid 31 3 (2024): 202-208. https://doi.org/10.1080/13506129.2024.2368860. 10.1080/13506129.2024.2368860 Pinheiro, Francisca; Varejão, Nathalia; Sánchez-Morales, Adrià; Bezerra, Filipa; Navarro, Susanna; Velázquez-Campoy, Adrián; Busqué, Félix; et al. "PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties". European Journal of Medicinal Chemistry 261 (2023): 115837. http://dx.doi.org/10.1016/j.ejmech.2023.115837. Open access • Published • 10.1016/j.ejmech.2023.115837 Maria Almeida; Pinheiro F; Irantzu Pallares; F. Peccati; Sánchez-Morales A; Varejão N; Bezerra F; et al. "Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.". Journal of medicinal chemistry (2022): https://doi.org/10.1021/acs.jmedchem.2c01195. 10.1021/acs.jmedchem.2c01195 Tiago Gião; Tiago Teixeira; Maria Rosário Almeida; Isabel Cardoso. "Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge". Biomedicines 10 2 (2022): 224-224. https://doi.org/10.3390/biomedicines10020224. 10.3390/biomedicines10020224 Filipa Bezerra; Christoph Niemietz; Hartmut H. J. Schmidt; Andree Zibert; Shuling Guo; Brett P. Monia; Paula Gonçalves; Maria João Saraiva; Maria Rosário Almeida. "In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis". International Journal of Molecular Sciences 22 17 (2021): 9488-9488. https://doi.org/10.3390/ijms22179488. 10.3390/ijms22179488 Bezerra, Filipa; Saraiva, Maria João; Almeida, Maria Rosário. "Modulation of the Mechanisms Driving Transthyretin Amyloidosis". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.592644. 10.3389/fnmol.2020.592644 Niemietz, Christoph; Bezerra, Filipa; Almeida, Maria Rosário; Guo, Shuling; Monia, Brett P.; Saraiva, Maria João; Schütz, Paula; Schmidt, Hartmut H.-J.; Zibert, Andree. "SERPINA1 modulates expression of amyloidogenic transthyretin". Experimental Cell Research 395 2 (2020): 112217. http://dx.doi.org/10.1016/j.yexcr.2020.112217. 10.1016/j.yexcr.2020.112217 Ferreira N; Maria João Saraiva; Maria Almeida. "Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/6/1287. 10.3390/ijms20061287 Bezerra, F.; Simões, C.J.V.; Beirão, J.M.; Saraiva, M.J.; Brito, R.M.M.; Almeida, M.R.; Bezerra, Filipa; et al. "Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous". Amyloid 26 sup1 (2019): 73-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069628713&partnerID=MN8TOARS. 10.1080/13506129.2019.1583193 Sant'Anna R; Almeida MR; Varejao N; Gallego P; Esperante S; Ferreira P; Pereira-Henriques A; et al. "Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.". (2017): http://europepmc.org/abstract/med/28338000. 10.1038/srep44709 Sant'Anna, Ricardo; Gallego, Pablo; Robinson, Lei Z.; Pereira-Henriques, Alda; Ferreira, Nelson; Pinheiro, Francisca; Esperante, Sebastian; et al. "Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity". Nature Communications 7 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000371136200001&KeyUID=WOS:000371136200001. 10.1038/ncomms10787 Ferreira, Nelson; Goncalves, Nadia P.; Saraiva, Maria J.; Almeida, Maria R.. "Curcumin: A multi-target disease-modifying agent for late-stage transthyretin amyloidosis". Scientific Reports 6 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376193300001&KeyUID=WOS:000376193300001. 10.1038/srep26623 Simoes, Carlos J. V.; Almeida, Zaida L.; Costa, Dora; Jesus, Catarina S. H.; Cardoso, Ana L.; Almeida, Maria R.; Saraiva, Maria J.; Pinho e Melo, Teresa M. V. D.; Brito, Rui M. M.. "A novel bis-furan scaffold for transthyretin stabilization and amyloid inhibition". European Journal of Medicinal Chemistry 121 (2016): 823-840. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382269700068&KeyUID=WOS:000382269700068. 10.1016/j.ejmech.2016.02.074 Teixeira, C.A.; Almeida, M.d.R.; Saraiva, M.J.. "Impairment of autophagy by TTR V30M aggregates: In vivo reversal by TUDCA and curcumin". Clinical Science 130 18 (2016): 1665-1675. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014362637&partnerID=MN8TOARS. 10.1042/CS20160075 Vilaro, Maria; Nieto, Joan; Ramon La Parra, Juan; Rosario Almeida, Maria; Ballesteros, Alfredo; Planas, Antoni; Arsequell, Gemma; Valencia, Gregorio. "Tuning Transthyretin Amyloidosis Inhibition Properties of lododiflunisal by Combinatorial Engineering of the Nonsalicylic Ring Substitutions". Acs Combinatorial Science 17 1 (2015): 32-38. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000347862500006&KeyUID=WOS:000347862500006. 10.1021/co5001234 Ventura, Salvador; Sant'Anna, Ricardo; Rosario Almeida, Maria; Reixach, Natalia; Insa, Raul; Velazquez-Campoy, Adrian; Reverter, David; Reig, Nuria. "Repositioning SOM0226 as a potent inhibitor of transthyretin amyloidogenesis and its associated cellular toxicity". Protein Science 24 (2015): 91-92. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000363658100155&KeyUID=WOS:000363658100155. Ferreira, N.; Pereira-Henriques, A.; Almeida, M.R.. "Transthyretin chemical chaperoning by flavonoids: Structure-activity insights towards the design of potent amyloidosis inhibitors". Biochemistry and Biophysics Reports 3 (2015): 123-133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939508272&partnerID=MN8TOARS. 10.1016/j.bbrep.2015.07.019 Ferreira, N.; Pereira-Henriques, A.; Attar, A.; Klärner, F.-G.; Schrader, T.; Bitan, G.; Gales, L.; Saraiva, M.J.; Almeida, M.R.. "Molecular Tweezers Targeting Transthyretin Amyloidosis". Neurotherapeutics 11 2 (2014): 450-461. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899492342&partnerID=MN8TOARS. 10.1007/s13311-013-0256-8 Batista, A. R.; Gianni, D.; Ventosa, M.; Coelho, A. V.; Almeida, M. R.; Sena-Esteves, M.; Saraiva, M. J.. "Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model (vol 21, pg 1041, 2014)". Gene Therapy 21 12 (2014): 1065-1065. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345930900009&KeyUID=WOS:000345930900009. 10.1038/gt.2014.111 Ferreira, N.; Santos, S.A.O.; Domingues, M.R.M.; Saraiva, M.J.; Almeida, M.R.. "Dietary curcumin counteracts extracellular transthyretin deposition: Insights on the mechanism of amyloid inhibition". Biochimica et Biophysica Acta - Molecular Basis of Disease 1832 1 (2013): 39-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868592337&partnerID=MN8TOARS. 10.1016/j.bbadis.2012.10.007 Ferreira, N.; Santos, S.; Domingues, M.; Saraiva, M. J.; Almeida, M. R.. "Curcumin inhibits transthyretin extracellular deposition in vivo: implications for Familial Amyloidotic Polyneuropathy (FAP) therapy". Febs Journal 280 (2013): 344-344. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000325919202097&KeyUID=WOS:000325919202097. Ferreira, N.; Saraiva, M.J.; Almeida, M.R.. "Natural polyphenols as modulators of TTR amyloidogenesis: In vitro and in vivo evidences towards therapy". Amyloid 19 SUPPL. 1 (2012): 39-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861433687&partnerID=MN8TOARS. 10.3109/13506129.2012.668502 Saraiva, M.J.; Magalhaes, J.; Ferreira, N.; Almeida, M.R.. "Transthyretin deposition in familial amyloidotic polyneuropathy". Current Medicinal Chemistry 19 15 (2012): 2304-2311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860663436&partnerID=MN8TOARS. Ferreira, N.; Saraiva, M.J.; Almeida, M.R.. "Epigallocatechin-3-gallate as a potential therapeutic drug for TTR-related amyloidosis: "In vivo" evidence from FAP mice models". PLoS ONE 7 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855650426&partnerID=MN8TOARS. 10.1371/journal.pone.0029933 Almeida, M.R.; Saraiva, M.J.. "Clearance of extracellular misfolded proteins in systemic amyloidosis: Experience with transthyretin". FEBS Letters 586 18 (2012): 2891-2896. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864931018&partnerID=MN8TOARS. 10.1016/j.febslet.2012.07.029 Ferreira, N.; Saraiva, M.J.; Almeida, M.R.. "Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation". FEBS Letters 585 15 (2011): 2424-2430. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960910835&partnerID=MN8TOARS. 10.1016/j.febslet.2011.06.030 Martinho, A.; Gonçalves, I.; Cardoso, I.; Almeida, M.R.; Quintela, T.; Saraiva, M.J.; Santos, C.R.A.. "Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin". FEBS Journal 277 16 (2010): 3427-3436. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=MN8TOARS. 10.1111/j.1742-4658.2010.07749.x Pessoa, J.; Sárkány, Z.; Ferreira-da-Silva, F.; Martins, S.; Almeida, M.R.; Li, J.; Damas, A.M.. "Functional characterization of Arabidopsis thaliana transthyretin-like protein". BMC Plant Biology 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949472438&partnerID=MN8TOARS. 10.1186/1471-2229-10-30 Liz, M.A.; Fleming, C.E.; Nunes, A.F.; Almeida, M.R.; Mar, F.M.; Choe, Y.; Craik, C.S.; et al. "Substrate specificity of transthyretin: Identification of natural substrates in the nervous system". Biochemical Journal 419 2 (2009): 467-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249132020&partnerID=MN8TOARS. 10.1042/BJ20082090 Mairal, T.; Nieto, J.; Pinto, M.; Almeida, M.R.; Gales, L.; Ballesteros, A.; Barluenga, J.; et al. "Iodine atoms: A new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors". PLoS ONE 4 1 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-59249100931&partnerID=MN8TOARS. 10.1371/journal.pone.0004124 Ferreira, N.; Cardoso, I.; Domingues, M.R.; Vitorino, R.; Bastos, M.; Bai, G.; Saraiva, M.J.; Almeida, M.R.. "Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity". FEBS Letters 583 22 (2009): 3569-3576. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749085436&partnerID=MN8TOARS. 10.1016/j.febslet.2009.10.062 González, A.; Quirante, J.; Nieto, J.; Almeida, M.R.; Saraiva, M.J.; Planas, A.; Arsequell, G.; Valencia, G.. "Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors". Bioorganic and Medicinal Chemistry Letters 19 17 (2009): 5270-5273. http://www.scopus.com/inward/record.url?eid=2-s2.0-68549085257&partnerID=MN8TOARS. 10.1016/j.bmcl.2009.03.004 Gonçalves, I.; Quintela, T.; Baltazar, G.; Almeida, M.R.; Saraiva, M.J.M.; Santos, C.R.. "Transthyretin interacts with metallothionein 2". Biochemistry 47 8 (2008): 2244-2251. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749120520&partnerID=MN8TOARS. 10.1021/bi7016377 Macedo, B.; Batista, A.R.; Ferreira, N.; Almeida, M.R.; Saraiva, M.J.. "Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy". Biochimica et Biophysica Acta - Molecular Basis of Disease 1782 9 (2008): 517-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349097870&partnerID=MN8TOARS. 10.1016/j.bbadis.2008.05.005 Gales, L.; Almeida, M.R.; Arsequell, G.; Valencia, G.; Saraiva, M.J.; Damas, A.M.. "Iodination of salicylic acid improves its binding to transthyretin". Biochimica et Biophysica Acta - Proteins and Proteomics 1784 3 (2008): 512-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-43049162388&partnerID=MN8TOARS. 10.1016/j.bbapap.2007.11.014 Cardoso, I.; Almeida, M.R.; Ferreira, N.; Arsequell, G.; Valencia, G.; Saraiva, M.J.. "Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: Relevance in drug design". Biochemical Journal 408 1 (2007): 131-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348960658&partnerID=MN8TOARS. 10.1042/BJ20070689 Magalhães, V.; Veiga-Malta, I.; Almeida, M.R.; Baptista, M.; Ribeiro, A.; Trieu-Cuot, P.; Ferreira, P.. "Interaction with human plasminogen system turns on proteolytic activity in Streptococcus agalactiae and enhances its virulence in a mouse model". Microbes and Infection 9 11 (2007): 1276-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-35148826082&partnerID=MN8TOARS. 10.1016/j.micinf.2007.06.001 Damas, A.M.; Almeida, M.R.; Gales, L.; Cardoso, I.; Saraiva, M.J.. "Pharmacologic approaches in the treatment of familial amyloidotic polyneuropathy \| Utilização de fármacos na terapia da polineuropatia amiloidótica familiar". Sinapse 6 1 SUPPL. 1 (2006): 168-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745382011&partnerID=MN8TOARS. Almeida, M.R.; Gales, L.; Damas, A.M.; Cardoso, I.; Saraiva, M.J.. "Small transthyretin (TTR) ligands as possible therapeutic agents in TTR amyloidoses". Current Drug Targets: CNS and Neurological Disorders 4 5 (2005): 587-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-26844484754&partnerID=MN8TOARS. 10.2174/156800705774322076 Maia, F.; Almeida, M.D.R.; Gales, L.; Kijjoa, A.; Pinto, M.M.M.; Saraiva, M.J.; Damas, A.M.. "The binding of xanthone derivatives to transthyretin". Biochemical Pharmacology 70 12 (2005): 1861-1869. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744528447&partnerID=MN8TOARS. 10.1016/j.bcp.2005.09.012 Almeida, M.R.; Macedo, B.; Cardoso, I.; Alves, I.; Valencia, G.; Arsequell, G.; Planas, A.; Saraiva, M.J.. "Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative". Biochemical Journal 381 2 (2004): 351-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242807241&partnerID=MN8TOARS. 10.1042/BJ20040011 Almeida, M.R.; Alves, I.L.; Terazaki, H.; Ando, Y.; Saraiva, M.J.. "Comparative studies of two transthyretin variants with protective effects on familial amyloidotic polyneuropathy: TTR R104H and TTR T119M". Biochemical and Biophysical Research Communications 270 3 (2000): 1024-1028. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034696835&partnerID=MN8TOARS. 10.1006/bbrc.2000.2554 Ando, Y.; Almeida, M.D.R.; Ohlsson, P.-I.; Ando, E.; Negi, A.; Suhr, O.; Terazaki, H.; et al. "Unusual self-association properties of transthyretin Y114C related to familial amyloidotic polyneuropathy: Effects on detection and quantification". Biochemical and Biophysical Research Communications 261 2 (1999): 264-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344069494&partnerID=MN8TOARS. 10.1006/bbrc.1999.1048 Almeida, M.R.; Damas, A.M.; Lans, M.C.; Brouwer, A.; Saraiva, M.J.. "Thyroxine binding to transthyretin Met 119: Comparative studies of different heterozygotic carriers and structural analysis". Endocrine 6 3 (1997): 309-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030885583&partnerID=MN8TOARS. Alves, I.L.; Altland, K.; Almeida, M.R.; Winter, P.; Saraiva, M.J.M.. "Screening and biochemical characterization of transthyretin variants in the Portuguese population". Human Mutation 9 3 (1997): 226-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030992434&partnerID=MN8TOARS. 10.1002/(SICI)1098-1004(1997)9:3<226::AID-HUMU3>3.0.CO;2-5 Saraiva, M.J.M.; Almeida, M.R.; Alves, I.L.; Bonifacio, M.J.; Damas, A.M.; Palha, J.A.; Goldsteins, G.; Lundgren, E.. "Modulating conformational factors in transthyretin amyloid". CIBA Foundation Symposia 199 (1996): 47-57. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030345867&partnerID=MN8TOARS. Almeida, M.R.; Saraiva, M.J.. "Thyroxine binding to transthyretin (TTR) variants - Two variants (TTR Pro 55 and TTR met 111) with a particularly low binding affinity". European Journal of Endocrinology 135 2 (1996): 226-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029831901&partnerID=MN8TOARS. Almeida, M.R.; Aoyama-Oishi, N.; Sakaki, Y.; Holmgren, G.; Ulf, D.; Ferlini, A.; Salvi, F.; et al. "Haplotype analysis of common transthyretin mutations". Human Genetics 96 3 (1995): 350-354. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029116835&partnerID=MN8TOARS. 10.1007/BF00210422 De Fatima Torres, M.; Do Rosario Almeida, M.; Joao Saraiva, M.. "TTR exon scanning in peripheral neuropathies". Neuromuscular Disorders 5 3 (1995): 187-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029020077&partnerID=MN8TOARS. 10.1016/0960-8966(94)00054-D Almeida, M.R.; Saraiva, M.J.. "TTR Leu 64 in an FAP kindred identified by PCR-RFLP analysis". AMYLOID 1 3 (1994): 184-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028082978&partnerID=MN8TOARS. 10.3109/13506129409148450 Almeida, M.D.R.; Lopez-Andreu, F.; Munar-Qués, M.; Costa, P.P.; Saraiva, M.J.. "Transthyretin ALA 71: A new transthyretin variant in a Spanish family with familial amyloidotic polyneuropathy". Human Mutation 2 5 (1993): 420-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027495964&partnerID=MN8TOARS. López Andreu, F.R.; Munar-Qués, M.; Parrilla, P.; Escribano Soriano, J.B.; Costa, P.P.; Costa, P.M.; Almeida, M.R.; et al. "Liver transplantation for the treatment of type I familial amyloidotic polyneuropathy \| Trasplante hepático para el tratamiento de la polineuropatía amiloidótica familiar tipo I.". Medicina Clinica 101 15 (1993): 581-583. http://www.scopus.com/inward/record.url?eid=2-s2.0-0039317638&partnerID=MN8TOARS. Alves, I.L.; Divino, C.M.; Schussler, G.C.; Altland, K.; Almeida, M.R.; Palha, J.A.; Coelho, T.; Costa, P.P.; Saraiva, M.J.M.. "Thyroxine binding in a TTR Met 119 kindred". Journal of Clinical Endocrinology and Metabolism 77 2 (1993): 484-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027240115&partnerID=MN8TOARS. Hesse, A.; Altland, K.; Linke, R.P.; Almeida, M.R.; Saraiva, M.J.M.; Steinmetz, A.; Maisch, B.. "Cardiac amyloidosis: A review and report of a new transthyretin (prealbumin) variant". British Heart Journal 70 2 (1993): 111-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027170502&partnerID=MN8TOARS. Saraiva, M.J.M.; Almeida, M.D.R.; Sherman, W.; Gawinowicz, M.; Costa, P.; Costa, P.P.; Goodman, D.S.. "A new transthyretin mutation associated with amyloid cardiomyopathy". American Journal of Human Genetics 50 5 (1992): 1027-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026724677&partnerID=MN8TOARS. Alves, I.L.; Almeida, M.R.; Skare, J.; Skinner, M.; Kurose, K.; Sakaki, Y.; Costa, P.P.; Saraiva, M.J.M.. "Amyloidogenic and non-amyloidogenic transthyretin Asn 90 variants". Clinical Genetics 42 1 (1992): 27-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026691223&partnerID=MN8TOARS. 10.1111/j.1399-0004.1992.tb03131.x Do Rosário Almeida, M.; Ferlini, A.; Forabosco, A.; Gawinowicz, M.; Costa, P.P.; Salvi, F.; Plasmati, R.; et al. "Two transthyretin variants (TTR ala-49 and TTR gin-89) in two sicilian kindreds with hereditary amyloidosis". Human Mutation 1 3 (1992): 211-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027023491&partnerID=MN8TOARS. 10.1002/humu.1380010306 Saraiva, M.J.M.; Almeida, M.D.R.; Alves, I.L.; Moreira, P.; Gawinowicz, M.; Costa, P.P.; Rauh, S.; Banhzoff, A.; Altland, K.. "Molecular analyses of an acidic transthyretin Asn 90 variant". American Journal of Human Genetics 48 5 (1991): 1004-1008. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025853733&partnerID=MN8TOARS. Almeida, M.R.; Hesse, A.; Steinmetz, A.; Maisch, B.; Altland, K.; Linker, R.P.; Gawinowicz, M.A.; Saraiva, M.J.M.. "Transthyretin Leu 68 in a form of cardiac amyloidosis". Basic Research in Cardiology 86 6 (1991): 567-571. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026331577&partnerID=MN8TOARS. 10.1007/BF02190707 Do Rosario Almeida, M.; Altland, K.; Rauh, S.; Gawinowicz, M.; Moreira, P.; Pinho Costa, P.; Joao Saraiva, M.. "Characterization of a basic transthyretin variant - TTR Arg 102 - in the German population". Biochimica et Biophysica Acta - Molecular Basis of Disease 1097 3 (1991): 224-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025939510&partnerID=MN8TOARS. 10.1016/0925-4439(91)90039-C Almeida, M.R.; Longo Alves, I.; Sakaki, Y.; Costa, P.P.; Saraiva, M.J.M.. "Prenatal diagnosis of familial amyloidotic polyneuropathy: Evidence for an early expression of the associated transthyretin methionine 30". Human Genetics 85 6 (1990): 623-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025076810&partnerID=MN8TOARS. 10.1007/BF00193586 Saraiva, M.J.M.; Costa, P.P.; Almeida, M.d.R.; Banzhoff, A.; Altland, K.; Ferlini, A.; Rubboli, G.; et al. "Familial amyloidotic polyneuropathy: transthyretin (prealbumin) variants in kindreds of Italian origin". Human Genetics 80 4 (1988): 341-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024232963&partnerID=MN8TOARS. 10.1007/BF00273648
Preprint	Tiago Gião; Miguel Tábuas-Pereira; Inês Baldeiras; Joana Saavedra; Alexandre Dias; Maria João Saraiva; Maria Rosário Almeida; Isabel Santana; Isabel Cardoso. "Transthyretin Levels and Instability in Alzheimer’s Disease: Correlations with AD Biomarkers in a Cohort Study". 2025. https://doi.org/10.1101/2025.01.24.634710. 10.1101/2025.01.24.634710

Intellectual property

Patent

Almeida, Maria. 2007. "Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils". United States.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/09/07	"In vitro and in vivo effects of SerpinA1 on the modulation of transthyretin proteolysis "	XVIII International Symposium on Amyloidosis, Heidelberg, Germany, September 4-8, 2022 Heidelberg University Hospital (Heidelberg, Germany)
2013/11/11	Molecular Tweezers targeting Transthyretin aggregation: therapeutic applications on Familial Amyloidotic Polyneuropathy	VIIIth International Symposium on Liver Transplantation in Familial Amyloidotic Polyneuropathy, (Rio de Janeiro, Brazil)
2012/11/27	Caracterização molecular das amiloidoses hereditárias de transtirretina: relevância no diagnóstico e terapia	I Workshop de Genética Translacional sob o tema «O diagnóstico molecular em Biomedicina Faculdade de Ciências da Saúde da Universidade Fernando Pessoa (Porto, Portugal)
2012/05/07	Curcumin as a novel natural compound acting as TTR amyloidosis inhibitor in vivo	International Symposium on Amyloidosis: From misfolded proteins to well-designed treatment (Groningen, Netherlands)
2011/11	Natural polyphenols as modulators of TTR amyloidogenesis: in vitro and in vivo evidences towards therapy	VIII International Symposium on Familial Amyloidotic Polyneuropathy, (Kumamoto, Japan)
2010/12/16	Epigallocatechin-3-gallate (EGCG) reduces transthyretin (TTR) amyloid deposition on an animal model for Familial Amyloidotic Polyneuropathy (FAP) - a possible therapeutic strategy	XVII th National Congress of Biochemistry (Porto, Portugal)
2008/06/27	Paramiloidose familiar – diagnóstico laboratorial e investigação.	Reunião de formação de internos de Genética Médica Instituto de Genética Médica (Porto, Portugal)
2007/03/17	Investigação em Ciências Biomédicas – Uma equipa multidisciplinar – A PAF como exemplo.	Congresso de Análises Clínicas e Saúde Pública (Figueira da Foz, Portugal)
2006/11/06	Reengineering TTR amyloid inhibition properties of diflunisal	XI th International Symposium in Amyloidosis Marine Biological Laboratory, Woods Hole, Massachusetts, USA (Woods Hole, Massachusetts, United States)
2006/04	Doenças neurodegenerativas – Abordagens terapêuticas na PAF	Tertúlias Científicas da Escola Superior de Enfermagem Instituto Superior Politécnico de Viana do Castelo, (Viana do Castelo, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/09/01 - Current	Effects of transthyretin (TTR) on cardiac angiogenesis – impact in Type 1 Diabetes Supervisor of Joana Pinho Barbosa	Biochemistry (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/09/01 - Current	Dissecting the role of Transthyretin (TTR) stabilization and proteolysis in Transthyretin Cardiac Amyloid pathogenesis Supervisor of João Pedro Ferreira Oliveira	Biologia Celular e Molecular (Master) Universidade do Porto Faculdade de Ciências, Portugal
2020/02/10 - Current	EPS-MOF two step method for recognition of plasma proteins in disease relevant conformation - apllication to transthyretin amyloidosis Co-supervisor of Diogo Alexandre da Costa Rodrigues	Programa Doutoral em Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - Current	Small molecules chaperones of the Transthyretin/Amyloid-beta interaction as a novel therapy for Alzheimer’s Disease - dissecting the mechanisms underlying TTR neuroprotection Co-supervisor	Molecular and Cell Biology (PhD) Universidade do Porto, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/01/01 - Current	Fabry disease: from iPS cells to genomic editing Co-supervisor of Ana Joana Borges Duarte	Programa Doutoral em Ciências Biomédicas (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/01 - 2022/11/10	Molecular mechanisms involved in Transthyretin Amyloidosis Supervisor	Biochemistry (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2018/11/14 - 2022/06/02	Modulation of mechanisms driving TTR amyloidogenesis: from tetramer destabilization to TTR proteolysis Supervisor of Carla Filipa Pereira Bezerra	Molecular and Cellular Biology (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006/12/01 - 2011/12/13	Modulation of transthyretin amyloidogenesis by small ligands: in vitro and in vivo studies. Supervisor of Nelson Carlos Gomes Ferreira	Biomedical Sciences (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002 - 2006/11/03	Efeitos de poluentes organoclorados no comportamento reprodutivo e no desenvolvimento larvar da tilápia nilótica, oreochromis niloticus Co-supervisor	Biomedical Sciences (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2024/05/26 - 2024/05/30	Poster XIX International Symposium on Amyloidosis- Testing optimized Tolcapone derivatives for plasma TTR stabilization aiming improved therapies in TTR amyloidosis Symposium	XIX International Symposium on Amyloidosis Mayo Clinic College of Medicine and Science, United States
2020/09/14 - 2020/09/18	Poster presentation: XVII International Symposium On Amyloidosis: "Effects of Serpina1 knockdown in TTR proteolysis in the heart of transgenic mice carrying human TTR V30M" Congress	The XVII International Symposium On Amyloidosis, Tarragona, Spain
2018/03/25 - 2018/08/29	Poster presentation - The XVIth International Symposium on Amyloidosis: "Targeting transthyretin amyloidosis in the eye with next-generation stabilizers: AT40 displays potent TTR stabilization in the human vitreous." Congress	The XVI International Symposium On Amyloidosis, Kumamoto, Japan
2018/03/26 - 2018/03/29	Poster presentation - The XVIth International Symposium on Amyloidosis: "Lead optimization of resilient next-generation transthyretin stabilizers for multiple target-product profiles: approaching the CNS" Congress	XVIth International Symposium on Amyloidosis, Kumamoto, Japan

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/10	Regulation of the yeast lysosome-like vacuole and its role in lifespan (Thesis) Arguer	Telma Filipa da Silva Martins (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024/04	Identifying the Critical Therapeutic Window for Molecular and Behavioural Correction of Angelman Syndrome (Thesis) Arguer	Sara Silva Santos (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023	The choroid plexus as a source and a target of Prolactin in the brain”. Doutoramento em Biomedicina, Faculdade de Ciências da Saúde, Universidade da Beira Interior (UBI), Covilhã, fevereiro de 2023. (Thesis) Main arguer	Ana Raquel Costa Brito (PhD) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022	“Mechanical principles driving microglia activation.” (Thesis) Arguer	Pedro Neves Melo (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022	“A robust study on the Ataxin-3 fibrillization pathway for the discovery of new inhibitor compounds. (Thesis) Arguer	Francisco Rosário Figueiredo (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022	Dissecting the mechanism of the receptor export module of the peroxisomal import machinery. (Thesis) Arguer	Ana Margarida Ferreira Guimarães Pedrosa (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/07	"Descubrimiento de fármacos contra la enfermedad de Alzheimer basados en la estabilidad de la transtiretina" (Thesis) Main arguer	Ellen Yadira Cotrina (PhD) Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona , Spain
2021/02	Characterization of bitter taste receptors expression and function in human blood cerebro-spinal fluid barrier (Thesis) Main arguer	Ana Catarina Abreu Duarte (PhD) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021	“Actin dysfunction in neurodegenerative disorders: Uncovering Co¬lin-1 pathology in Lewy Body dementias”. Doutoramento em Biologia Molecular e Celular, ICBAS, UP, 2021. (Thesis) Arguer	Marina Isabel Oliveira da Silva (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/07	The physics of the phase transition in crystallogenesis and amyloid fibrillogenesis (Thesis) Main arguer	Rosa Crespo Rodriguez (PhD) Universidade do Porto Faculdade de Engenharia, Portugal
2016	Unravelling modulators of age-at-onset variability in FAP ATTRV30M (Thesis) Main arguer	Andreia Dias (Master) Universidade do Porto Faculdade de Ciências, Portugal
2015/07	Transthyretin Familial Amyloidotic Polyneuropathy: novel therapeutic derived from drug repurposing and new insights in diagnosis through proteomic analysis of clinical samples (Thesis) Main arguer	Marta Vilá Rico (PhD) Universitat de Ramon Llull Institut Quimic Sarria, Spain
2015/07	Transthyretin Familial Amyloidotic Polyneuropathy: novel therapeutic derived from drug repurposing and new insights in diagnosis through proteomic analysis of clinical samples (Thesis) Main arguer	Marta Vilá Rico (PhD) Universitat de Ramon Llull Institut Quimic Sarria, Spain
2015	Transthyretin Familial Amyloidotic Polyneuropathy: novel therapeutic derived from drug repurposing and new insights in diagnosis through proteomic analysis of clinical samples Doutoramento em Química, Institut Químic de Sarrià, Universitat de Ramon Llull, Barcelona, Espanha, julho 2015. (Thesis) Main arguer	Marta Vilá Rico (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/02	Drug Discovery Targeted to Transthyretin Related Amyloidosis (Thesis) Main arguer	Daniel Blasi Pérez (PhD) Universitat de Barcelona Facultat de Química, Spain
2013/02	Drug Discovery Targeted to Transthyretin Related Amyloidosis (Thesis) Main arguer	Daniel Blasi Pérez (PhD) Universitat de Barcelona Facultat de Química, Spain
2012/12	The role of plasmalogens in the formation and maintenance of myelin in the central nervous system (Thesis) Main arguer	Ana Rita Alves Malheiro (Master) Instituto Universitário de Ciências da Saúde, Portugal
2012/01	Expressão de transtirretina no sistema gastro-intestinal do murganho (Thesis) Main arguer	Susete Marlene Machado Costelha (Master) Instituto Politécnico do Porto Escola Superior de Educação, Portugal
2010/11	Identifying proteins differentially expressed following conditioning lesions (Thesis) Main arguer	Daniela Filipa Lage da Silva (Master) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010/05/20	Molecular pathophysiology underlyng neuronal ceroid lipofuscinoses: CLN2 and CLN5 (Thesis) Main arguer	Carlos Jorge Pereira Bessa (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010/05	Molecular pathophysiology underlyng neuronal ceroid lipofuscinoses: CLN2 and CLN5 (Thesis) Main arguer	Carlos Jorge Pereira Bessa (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2010/03/19	Regulation of transthyretin levels in murine choroid plexuses by sex steroid hormones (Thesis) Main arguer	Telma Alexandra Quintela Paixão (PhD) Universidade da Beira Interior, Portugal
2007/12/20	Pathogenesis of Rett syndrome and study of the role of meCP2 protein in neuronal function. (Thesis) Main arguer	Mónica Joana Pinto dos Santos (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006/03	Molecular pathophysiological studies od neuronal ceroid lipofuscinoses (Thesis) Main arguer	Carla Andreia Fidalgo Teixeira (PhD) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2002/06	A cardosina A, uma proteína vegetal como modelo para estudos de comportamento em solventes orgânicos. Da biocatálise à química de proteínas (Thesis) Main arguer	Ana Cristina de Fraga Esteves Sarmento (PhD) Universidade de Aveiro, Portugal
1997	Alergenicidade e actividade proteolítica em pólens de Parietária sp (Thesis) Main arguer	Maria Margarida Pais de Sousa Costa Pinto Teixeira Dias (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Association member

	Society Organization name	Role
2024 - Current	International Society of Amyloidosis - ISA	Member 806
1988 - Current	Sociedade Portuguesa de Bioquímica	Associate Member

Committee member

	Activity description Role	Institution / Organization
2023 - Current	Accompanying comission of Master Course in Biochemistry Member	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006 - Current	Director & Co/Director of First Degree Course in Biochemistry (2012/06 - ) Director	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/06 - 2021/06	Director & Co/Director of First Degree Course in Biochemistry Director	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Conference scientific committee

	Conference name	Conference host
2022/05/18 - 2022/05/18	Simpósio: Formação e Investigação em Bioquímica: 40 anos da Licenciatura em Bioquímica na U. Porto	Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto
2019/11/13 - 2019/11/13	Simpósio: Formação e Investigação em Bioquímica - Pedro Moradas Ferreira, 4 décadas de atividades na U.Porto	ICBAS- Instituto Ciências Biomédicas de Abel Salazar, Universidade do Porto,
2019/03/21 - 2019/03/22	Strategies and tools for modulating pathologic protein self-assembly	Universidade do Porto I3S Instituto Investigação e Inovação Pedagógica
2000/09 - 2000/09	Congresso Nacional de Bioquímica» realizado em Setembro de 2000 na Póvoa de Varzim, Portugal.	Póvoa de Varzim, Portugal
1995/10 - 1995/10	3rd International Symposium on Familial Amyloidotic Polyneuropathy and other transthyretin related disorders

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2018 - Current	Biochemistry II	First Degree in Biochemistry (Licenciatura)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - Current	Biochemistry	Biochemistry (Mestrado integrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - Current	Structure and Function of Proteins	Master (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - Current	Structure and Function of Proteins	Master in Bioengeneering (Mestrado integrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1999 - Current	Laboratory of Biophysics/Biochemistry	Biochemistry and Biophysics (Licenciatura)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1995 - Current	Biochemistry I	Graduation in Biochemistry (Licenciatura)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007 - 2016	Complements of Molecular Biology	Complements of Molecular Biology (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Mentoring / Tutoring

	Topic	Student name
2012/01/01 - 2014/12/30	Characterization of the mechanism of action of natural and synthetic inhibitors of transthyretin amyloidosis: Therapeutic applications in FAP	Nelson Carlos Gomes Ferreira (Pos-Doc fellow)
2007/01/01 - 2009/12/30	Identification and characterization of new transthyretin-protein interactions – contributions to the elucidation of TTR biology	Elsa Fernandes Leitão (Pos-Doc fellow)