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Miguel de Almeida Fuzeta. Concluiu o(a) Mestrado integrado em Engenharia Biológica em 2016/09/29 pelo(a) Universidade de Lisboa Instituto Superior Técnico e Doutoramento em Bioengenharia em 2021/10/27 pelo(a) Universidade de Lisboa Instituto Superior Técnico. É Investigador no(a) Instituto de Biologia Experimental e Tecnológica. Publicou 5 artigos em revistas especializadas. Possui 1 capítulo(s) de livros. Recebeu 9 prémio(s) e/ou homenagens. Participa e/ou participou como Investigador em 2 projeto(s) e Investigador Pós-doutorado em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Biotecnologia Médica com ênfase em Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo, Ciências da Engenharia e Tecnologias com ênfase em Biotecnologia Industrial com ênfase em Tecnologias de BioProcessamento e Ciências da Engenharia e Tecnologias com ênfase em Nanotecnologia.
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Identification

Personal identification

Full name
Miguel de Almeida Fuzeta

Citation names

  • Fuzeta, Miguel de Almeida

Author identifiers

Ciência ID
D81C-5943-B320
ORCID iD
0000-0002-2656-6024

Email addresses

  • miguel.fuzeta@ibet.pt (Professional)

Addresses

  • Apartado 12, 2781-901, Oeiras, Oeiras, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Nano-technology
  • Engineering and Technology - Industrial Biotechnology - Bioprocessing Technologies

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2017/01/01 - 2021/10/27
Concluded
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Scalable Production of Extracellular Vesicles Derived from Mesenchymal Stromal Cells for Cancer-Targeted Drug Delivery" (THESIS/DISSERTATION)
 Approvado com distinção (Tese); 19/20 (parte curricular)
2011/09 - 2016/09/29
Concluded
 Engenharia Biológica (Mestrado integrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Interactions between cancer cell populations in vivo: cooperation vs competition" (THESIS/DISSERTATION)
 17/20 (BSc); 18/20 (MSc)
Affiliation

Science

Category
Host institution 		Employer
2024/04 - Current Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
2022/09 - 2024/03 Postdoc (Research) Fundação Champalimaud, Portugal
Fundação Champalimaud, Portugal
2022/02/02 - 2022/06 Contracted Researcher (Research) Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Contract

Designation Funders
2024/04 - Current Next generation, off-the-shelf, dual targeted tandem CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic leukemia (CARxALL).
101113067
Researcher
European Innovation Council
Ongoing
2022/02/02 - 2022/06 Desenvolvimento de um processo de cultura escalável para produção de exosomas terapêuticos derivados de células estaminais/estromais mesenquimatosas humanas
PTDC/EQU-EQU/31651/2017
Post-doc
Universidade de Lisboa Instituto Superior Técnico, Portugal
Ongoing
2018/10/01 - 2021/10/27 Desenvolvimento de um processo de cultura escalável para produção de exosomas terapêuticos derivados de células estaminais/estromais mesenquimatosas humanas
PTDC/EQU-EQU/31651/2017
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. de Almeida Fuzeta, Miguel; de Matos Branco, André Dargen; Fernandes-Platzgummer, Ana; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Addressing the Manufacturing Challenges of Cell-Based Therapies". In Current Applications of Pharmaceutical Biotechnology, 225-278. Springer International Publishing, 2019.
    Published • 10.1007/10_2019_118
Conference poster
  1. Painho, Beatriz; Costa, Catarina; Fuzeta, Miguel de Almeida ; Duarte, Nádia; Pérez, Laura G.; Casadó, Sergi; Díaz, Victor M.; et al. "Scalable and Chemically-Defined Differentiation Bioprocess to Generate gamma delta T Cells from Hematopoietic Stem/Progenitor Cells". Paper presented in Biomanufacturing Without Borders, Lisboa, Portugal, 2024.
  2. Painho, Beatriz; Costa, Catarina; Fuzeta, Miguel de Almeida ; Duarte, Nádia; Pérez, Laura G.; Casdó, Sergi; Díaz, Victor M.; et al. "Scalable and chemically-defined differentiation strategy to generate gamma delta T cells from hematopoietic stem/progenitor cells". Paper presented in International Society for Cell and Gene Therapy Europe Regional Meeting 2024, Gothenburg, Sweden, 2024.
  3. Fuzeta, Miguel de Almeida ; Bernardes, Nuno; Roefs, Marieke T. ; van de Wakker, Simonides I; Olijve, Wilte; Fernandes-Platzgummer, Ana; Vader, Pieter; et al. "Scalable manufacturing of human mesenchymal stromal cell-derived extracellular vesicles with angiogenic potential". Paper presented in European Society for Animal Cell Technology Meeting 2022. Lisbon, Portugal., 2022.
  4. Fuzeta, Miguel de Almeida ; Bernardes, Nuno; Roefs, Marieke T. ; van de Wakker, Simonides I; Olijve, Wilte; Lin, Yee-Hsien; Jung, Sunghoon; et al. "Scalable bioreactor production and angiogenic potential of extracellular vesicles derived from human mesenchymal stromal cells.". Paper presented in International Society for Cell and Gene Therapy Meeting 2022. San Francisco, California, USA., 2022.
  5. Miguel de Almeida Fuzeta; Bernardes, Nuno; van de Wakker, Simonides I; Roefs, Marieke T. ; Olijve, Wilte; Fernandes-Platzgummer, Ana; Vader, Pieter; et al. "Scalable bioreactor production and angiogenic potential of extracellular vesicles derived from human mesenchymal stromal cells.". Paper presented in International Society for Extracellular Vesicles Meeting 2021, 2021.
  6. Fuzeta, Miguel de Almeida ; Oliveira, Filipa D.; Costa, Ana Catarina; Fernandes-Platzgummer, Ana; Jung, Sunghoon; Tseng, Rong-Jeng; Milligan, William; et al. "Manufacturing Extracellular Vesicles Derived from Human Mesenchymal Stromal Cells (MSC) in Bioreactors for Cancer Therapy.". Paper presented in International Society for Extracellular Vesicles Meeting 2020, 2020.
  7. Fuzeta, Miguel de Almeida ; Oliveira, Filipa D; Costa, Ana Catarina; Fernandes-Platzgummer, Ana; Bernardes, Nuno; Gaspar, Diana; Cabral, Joaquim M S; Lobato da Silva, Cláudia. "Scalable Production of Human Mesenchymal Stem/Stromal Cell (MSC)-Derived Extracellular Vesicles in Vertical-Wheel Bioreactors for Cancer Therapy". Paper presented in Stem Cell Community Day. Lisboa, Portugal, 2019.
  8. Fuzeta, Miguel de Almeida ; Oliveira, Filipa D; Fernandes-Platzgummer, Ana; Bernardes, Nuno; Gaspar, Diana; Cabral, Joaquim M. S.; Lobato da Silva, Cláudia. "Manufacturing Extracellular Vesicles Derived from Human Mesenchymal Stem/Stromal Cells (MSC) in Vertical-Wheel Bioreactors". Paper presented in Encontro Ciência 2019. Lisboa, Portugal, 2019.
  9. Fuzeta, Miguel de Almeida ; Pinto, Diogo de Sousa; Oliveira, Filipa D; Rodrigues, Carlos A V; Fernandes-Platzgummer, Ana; Jung, Sunghoon; Tseng, Rong-Jeng; et al. "Manufacturing Human Mesenchymal Stem/Stromal Cells (MSC) and MSC-Derived Extracellular Vesicles in Vertical-Wheel Bioreactors". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI. Coronado, California, USA, 2019.
  10. Fuzeta, Miguel de Almeida ; Pinto, Diogo de Sousa; Oliveira, Filipa D; Rodrigues, Carlos A V; Fernandes-Platzgummer, Ana; Jung, Sunghoon; Lee, Brian; et al. "Manufacturing Human Mesenchymal Stem/Stromal Cells and Derived Extracellular Vesicles in Single-use Vertical-Wheel Bioreactors". Paper presented in Secretome Without Borders 2018. Braga, Portugal, 2018.
Journal article
  1. Marques, Cláudia Raquel; Fuzeta, Miguel de Almeida ; dos Santos Cunha, Raquel Medina; Pereira-Sousa, Joana; Silva, Deolinda; Campos, Jonas; Teixeira-Castro, Andreia; et al. "Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems". Biomedicines 11 5 (2023): 1240. http://dx.doi.org/10.3390/biomedicines11051240.
    10.3390/biomedicines11051240
  2. de Almeida Fuzeta, Miguel; Gonçalves, Pedro P.; Fernandes-Platzgummer, Ana; Cabral, Joaquim M. S.; Bernardes, Nuno; da Silva, Cláudia L.. "From Promise to Reality: Bioengineering Strategies to Enhance the Therapeutic Potential of Extracellular Vesicles". Bioengineering 9 11 (2022): 675. http://dx.doi.org/10.3390/bioengineering9110675.
    10.3390/bioengineering9110675
  3. Póvoa, Vanda; Rebelo de Almeida, Cátia; Maia-Gil, Mariana; Sobral, Daniel; Domingues, Micaela; Martinez-Lopez, Mayra; de Almeida Fuzeta, Miguel; et al. "Innate immune evasion revealed in a colorectal zebrafish xenograft model". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-21421-y.
    Published • 10.1038/s41467-021-21421-y
  4. de Almeida Fuzeta, Miguel; Bernardes, Nuno; Oliveira, Filipa D.; Costa, Ana Catarina; Fernandes-Platzgummer, Ana; Farinha, José Paulo; Rodrigues, Carlos A. V.; et al. "Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.553444.
    Published • 10.3389/fcell.2020.553444
  5. Pinto, Diogo; Bandeiras, Cátia; Fuzeta, Miguel; Rodrigues, Carlos A. V.; Jung, Sunghoon; Hashimura, Yas; Tseng, Rong-Jeng; et al. "Scalable Manufacturing of Human Mesenchymal Stromal Cells in the Vertical-Wheel Bioreactor System: An Experimental and Economic Approach". Biotechnology Journal 14 8 (2019): 1800716. http://dx.doi.org/10.1002/biot.201800716.
    10.1002/biot.201800716
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/03 Scalable bioreactor production and angiogenic potential of extracellular vesicles derived from human mesenchymal stromal cells 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Braga, Portugal)
2021/05/26 Scalable Xeno-free Production of MSC-Derived EVs in Single-use Bioreactors (AventaCell Global Showcase) International Society for Cell and Gene Therapy Meeting 2021
International Society for Cell and Gene Therapy
2020/05/28 Scalable Production of Human Mesenchymal Stromal Cell (MSC)-Derived Extracellular Vesicles in Microcarrier-based Bioreactors under Xeno(geneic)-free Conditions International Society for Cell and Gene Therapy Meeting 2020
International Society for Cell and Gene Therapy (Paris, France)
2019/10 Scalable Production of Human Mesenchymal Stem/Stromal Cell (MSC)-Derived Extracellular Vesicles in Vertical-Wheel Bioreactors. 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019/09 Manufacturing Human Mesenchymal Stem/Stromal Cell (MSC)-Derived Extracellular Vesicles in Vertical-Wheel Bioreactors for Cancer Therapy EACR conference on Nanotechnology in Cancer
European Association for Cancer Research (Cambridge, United Kingdom)
Distinctions

Award

2022 Conference Scholarship Award
Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2022 Conference Bursary Award
European Society for Animal Cell Technology, Germany
2019 Scientific Meeting Bursary Award
European Association For Cancer Research, United Kingdom

Worldwide Cancer Research, United Kingdom
2017 Bolsa de Doutoramento, Programa MIT Portugal
Fundação para a Ciência e a Tecnologia, Portugal
2016 Mérito Académico
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Mérito Académico
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 Mérito Académico
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 Mérito Académico
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 Mérito Académico
Universidade de Lisboa Instituto Superior Técnico, Portugal