Mariana Antunes Castelôa (D81A-1E0E-3E72)

Curriculum Vitae

Mariana Antunes Castelôa

Mariana Castelôa has completed her Bachelor's degree in Biochemistry in 2019 and her Master's degree in Applications in Biotechnology and Synthetic Biology in 2021, both by FCUP - Faculty of Sciences of the University of Porto. During her Master's dissertation, she worked at FFUP - Faculty of Pharmacy of the University of Porto, evaluating the pharmacological effects of bioactive compounds. In her academic curriculum, she has 3 oral communications with abstract publication, 2 posters, and is the first author of 1 article published in a high-impact peer-review international journal. She was also a co-supervisor of a BSc international student. Currently, she is working with a Master Research Grant at CIQUP - Research Center in Chemistry of the University of Porto, integrated with the FCT-funded project NOXIOUS (EXPL/BIABQM/0492/2021), which aims to develop targeted covalent inhibitors to unravel NOX2 crystal structure.

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Identification

Personal identification

Full name: Mariana Antunes Castelôa

Citation names

Castelôa, Mariana
Castelôa, M.

Author identifiers

Ciência ID: D81A-1E0E-3E72
ORCID iD: 0000-0002-0913-3219

Knowledge fields

Natural sciences - Biological Sciences - Biochemistry

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2022/10 - 2026 Ongoing	Química (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2022/04 - 2022/09 Concluded	Curso de Estudos Avançados em Projeto Científico e Tecnológico (Outros) Universidade do Porto Faculdade de Ciências, Portugal	19
2019 - 2021 Concluded	Aplicações em Biotecnologia e Biologia Sintética (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal "In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer " (THESIS/DISSERTATION)	18
2016 - 2019 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "The importance of fertility preservation in cancer patients treated with cyclophosphamide" (THESIS/DISSERTATION)	15

Affiliation

Others

	Category Host institution	Employer
2022/10 - Current	PhD Student Fellow	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2022/04 - 2022/09	Master Research Fellow	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal

Projects

Grant

	Designation	Funders
2022/04 - Current	NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L. Spallanzani, Italy	Fundação para a Ciência e a Tecnologia Ongoing

Outputs

Publications

Conference abstract	Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines". Paper presented in 14th Edition of IJUP (Young Research Meeting of University of Porto), Porto, 2021. Published Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno M.; Rebelo, Irene. "The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells". Paper presented in 1st Edition of BioSynBio (One-Day Meeting on Biotechnology and Synthetic Biology of FCUP), 2021. Published Magalhães, Ana; Castelôa, Mariana; Moreira-Pinto, Beatriz; Fonseca, Bruno M.; Rebelo, Irene. "In vitro study of the granulosa cells response to activated THP-1 derived macrophages". Paper presented in 13th Edition of IJUP (Young Research Meeting of University of Porto), Porto, 2020. Published
Conference poster	Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno M.; Rebelo, Irene. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type 1 and type 2 endometrial cancer cell lines". Paper presented in University Olympiad in Biochemistry COVID-19 Special Edition, 2021. Magalhães, Ana; Moreira-Pinto, Beatriz; Castelôa, Mariana; Fonseca, Bruno M.; Rebelo, Irene. "Activated macrophages induce inflammatory COX-2 expression in human ovarian granulosa cells". Paper presented in 15th Edition of YES (Young European Scientist) Meeting, 2020.
Journal article	Castelôa, M.; Moreira-Pinto, B.; Benfeito, S.; Borges, F.; Fonseca, B. M.; Rebelo, I.. "In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer". Biomedicines 10 4 (2022): Open access • Published • 10.3390/biomedicines10040800
Thesis / Dissertation	Castelôa, Mariana. "In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer". Master, Universidade do Porto Faculdade de Ciências, 2021. https://hdl.handle.net/10216/137988. Castelôa, Mariana. "The importance of fertility preservation in cancer patients treated with cyclophosphamide". Degree, Universidade do Porto Faculdade de Ciências, 2019.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021/05	Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines	14ª Edição do IJUP (Encontro de Investigação Jovem da Universidade do Porto) Universidade do Porto (Porto, Portugal)
2021/04	The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells	1ª Edição do BioSynBio (One-Day Meeting on Biotechnology and Synthetic Biology of FCUP) Universidade do Porto Faculdade de Ciências (Portugal)
2020/02	In vitro study of the granulosa cells response to activated THP-1 derived macrophages	13ª Edição do IJUP (Encontro de Investigação Jovem da Universidade do Porto) Universidade do Porto (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021/05 - 2021/07	The inflammatory microenvironment within the ovary and female infertility: effects on granulosa cells function Co-supervisor of Symeon Gerasimou	BSc Hons in Immunology & Microbiology (Degree) University of Strathclyde Institute of Pharmacy & Biomedical Sciences, United Kingdom Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2021/05 - 2021/05	Workshops de Cosmetologia, Cultura Celular e Imunohistoquímica Congress	VI Jornadas da Bioquímica Universidade do Porto Faculdade de Ciências, Portugal
2019/05 - 2019/05	Workshops de Resposta Inflamatória, Nanomedicina, Alimentos Bioativos, Eletrónica e Instrumentação em Ciências Biomédicas e Identificação de Determinantes Moleculares Essenciais para Metástase Congress	VII AEICBAS Biomedical Congress Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/03 - 2019/03	Workshops de Modelos Biológicos e Diagnóstico Molecular Congress	V Jornadas da Bioquímica Universidade do Porto Faculdade de Ciências, Portugal
2018/03 - 2018/03	Workshops de Epigenética do Cancro e Química Medicinal Meeting	XI Encontro Nacional de Estudantes de Bioquímica Universidade do Porto Faculdade de Ciências, Portugal