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Mariana Castelôa completed her BSc in Biochemistry in 2019 and her MSc in Applications in Biotechnology and Synthetic Biology in 2021, at FCUP - Faculty of Sciences of the University of Porto. During her Master's dissertation, she worked at FFUP - Faculty of Pharmacy of the University of Porto, evaluating the pharmacological effects of bioactive compounds, where she was also a co-supervisor of a BSc international student. In 2022, she worked with a Master Research Grant at CIQUP - Research Center in Chemistry of the University of Porto, integrated with the FCT-funded project NOXIOUS (EXPL/BIABQM/0492/2021), which aims to develop targeted covalent inhibitors to unravel NOX2 crystal structure, counting with the collaboration of Prof. Andrea Mattevi (UniPV, Italy). Currently, she is enrolled in the Doctoral Program in Chemistry at FCUP, developing her PhD thesis entitled "Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases". In her academic curriculum, she has 5 oral communications with abstract publication, 7 posters, the first author of 1 article and co-author in another one.
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Identification

Personal identification

Full name
Mariana Antunes Castelôa

Citation names

  • Castelôa, Mariana
  • Castelôa, M.

Author identifiers

Ciência ID
D81A-1E0E-3E72
ORCID iD
0000-0002-0913-3219

Email addresses

  • up201606405@fc.up.pt (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2022/10 - 2026
Ongoing
 Química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
"Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases" (THESIS/DISSERTATION)
2022/04 - 2022/09
Concluded
 Curso de Estudos Avançados em Projeto Científico e Tecnológico (Outros)
Universidade do Porto Faculdade de Ciências, Portugal
 19
2019 - 2021
Concluded
 Aplicações em Biotecnologia e Biologia Sintética (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer " (THESIS/DISSERTATION)
 18
2016 - 2019
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"The importance of fertility preservation in cancer patients treated with cyclophosphamide" (THESIS/DISSERTATION)
 15
Affiliation

Others

Category
Host institution 		Employer
2022/10 - Current PhD Student (FCT Grant - 2022.13356.BD) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
2024/05 - 2024/12 Visiting PhD Student Fundação para a Ciência e a Tecnologia, Portugal
Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L Spallanzani, Italy
2022/04 - 2022/09 Master Research Fellow (NOXIous Project - EXPL/BIA-BQM/0492/2021) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Centro de Investigação em Química, Portugal
Projects

Grant

Designation Funders
2023 - 2025 DeFend: De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators
2022.04633.PTDC
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

Salk Institute for Biological Studies, United States
Fundação para a Ciência e a Tecnologia
Ongoing
2022/05 - 2023/07 NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure
EXPL/BIA-BQM/0492/2021
PhD Student Fellow
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L. Spallanzani, Italy
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Castelôa, Mariana; Massari, Marta; Marchese, Sara; Lima, Carla; Reis, Joana; Basile, Lorenzo; Borges, Fernanda; et al. "Advancing NOX Inhibition: Development of Potent and Isoform-Selective Targeted Covalent Inhibitors". Paper presented in 32nd Young Research Fellows Meeting, Paris, 2025.
    Published
  2. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Insights into the Development of Isoform-Selective, Non-Interfering NOX Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network & COST ACTION, Rome, 2024.
    Published
  3. Lima, Inês; Castelôa, Mariana; Chavarria, Daniel; Conde, Carlos; Pombinho, António; Borges, Fernanda. "High throughput screening of heterocyclic compounds to identify new spindle assembly checkpoint inhibitors". Paper presented in 17th University of Porto Young Research Meeting (IJUP), Porto, 2024.
    Published
  4. Castelôa, Mariana; Lima, Carla; Benfeito, Sofia; Aguiar, Brandon; Soares, Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network, Thessaloniki, 2023.
    Published
  5. Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Galician-Portuguese International Conference on Chemistry, Santiago de Compostela, 2022.
    Published
  6. Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines". Paper presented in 14th University of Porto Young Research Meeting (IJUP), Porto, 2021.
    Published
  7. Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells". Paper presented in 1st One-Day Meeting on Biotechnology and Synthetic Biology, Porto, 2021.
    Published
  8. Magalhães, Ana; Castelôa, Mariana; Moreira-Pinto, Beatriz; Fonseca, Bruno; Rebelo, Irene. "In vitro study of the granulosa cells response to activated THP-1 derived macrophages". Paper presented in 13th University of Porto Young Research Meeting (IJUP), Porto, 2020.
    Published
  9. Magalhães, Ana; Moreira-Pinto, Beatriz; Castelôa, Mariana; Fonseca, Bruno; Rebelo, Irene. "Activated macrophages induce inflammatory COX-2 expression in human ovarian granulosa cells". Paper presented in 15th Edition of YES (Young European Scientist) Meeting, Porto, 2020.
    Published
  10. Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno; Rebelo, Irene. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type 1 and type 2 endometrial cancer cell lines". Paper presented in University Olympiad in Biochemistry COVID-19 Special Edition, Coimbra, 2020.
    Published
Conference poster
  1. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Recent Advances in the Discovery of Isoform-Selective NOX Inhibitors". Paper presented in Encontro Ciência 2024, 2024.
  2. Castelôa, Mariana; Reis, Joana; Lima, Carla; Massari, Marta; Marchese, Sara; Basile, Lorenzo; Borges, Fernanda; et al. "Insights into the Development of Isoform-Selective, Non-Interfering NOX Inhibitors". Paper presented in MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro-PhD Network & COST ACTION, 2024.
  3. Lima, Inês; Castelôa, Mariana; Chavarria, Daniel; Conde, Carlos; Pombinho, António; Borges, Fernanda. "High throughput screening of heterocyclic compounds to identify new spindle assembly checkpoint inhibitors". Paper presented in 17th University of Porto Young Research Meeting (IJUP), 2024.
  4. Castelôa, Mariana; Lima, Carla; Benfeito, Sofia; Aguiar, Brandon; Soares, Pedro; Borges, Fernanda; Chavarria, Daniel. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network, 2023.
  5. Castelôa, Mariana; Soares, Pedro; Benfeito, Sofia; Lima, Carla; Borges, Fernanda; Chavarria, Daniel. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Galician-Portuguese International Conference on Chemistry, 2022.
  6. Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno M.; Rebelo, Irene. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type 1 and type 2 endometrial cancer cell lines". Paper presented in University Olympiad in Biochemistry COVID-19 Special Edition, 2021.
  7. Magalhães, Ana; Moreira-Pinto, Beatriz; Castelôa, Mariana; Fonseca, Bruno M.; Rebelo, Irene. "Activated macrophages induce inflammatory COX-2 expression in human ovarian granulosa cells". Paper presented in 15th Edition of YES (Young European Scientist) Meeting, 2020.
Journal article
  1. Noce, Beatrice; Marchese, Sara; Massari, Marta; Lambona, Chiara; Reis, Joana; Fiorentino, Francesco; Raucci, Alessia; et al. "Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor". Journal of Medicinal Chemistry (2025): https://doi.org/10.1021/acs.jmedchem.4c02644.
    Open access • Published • 10.1021/acs.jmedchem.4c02644
  2. Castelôa, Mariana; Moreira-Pinto, Beatriz; Benfeito, Sofia; Borges, Fernanda; Fonseca, Bruno M.; Rebelo, Irene. "In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer". Biomedicines 10 4 (2022): 800. https://doi.org/10.3390/biomedicines10040800.
    Open access • Published • 10.3390/biomedicines10040800
Thesis / Dissertation
  1. Castelôa, Mariana. "In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer". Master, Universidade do Porto Faculdade de Ciências, 2021. https://hdl.handle.net/10216/137988.
  2. Castelôa, Mariana. "The importance of fertility preservation in cancer patients treated with cyclophosphamide". Degree, Universidade do Porto Faculdade de Ciências, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/04 The quest for isoform-selective NOX inhibitors: challenges and advances 20th Hellenic Symposium on Medicinal Chemistry
University of Ioannina (Ioannina, Greece)
2025/02 Advancing NOX Inhibition: Development of Potent and Isoform-Selective Targeted Covalent Inhibitors 32nd Young Research Fellows Meeting
Université Paris Cité UFR de Pharmacie, France (Paris, France)
2021/05 Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines 14th University of Porto Young Research Meeting (IJUP)
Universidade do Porto (Porto, Portugal)
2021/04 The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells 1st One-Day Meeting on Biotechnology and Synthetic Biology
Universidade do Porto Faculdade de Ciências (Portugal)
2020/02 In vitro study of the granulosa cells response to activated THP-1 derived macrophages 13th University of Porto Young Research Meeting (IJUP)
Universidade do Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/05 - 2021/07 The inflammatory microenvironment within the ovary and female infertility: effects on granulosa cells function
Co-supervisor of Symeon Gerasimou
 BSc Hons in Immunology & Microbiology (Degree)
University of Strathclyde Institute of Pharmacy & Biomedical Sciences, United Kingdom

Universidade do Porto Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06/26 - 2023/07/12 Co-organizer/Trainer of the international course "Drug Discovery 2030: A Roadmap for a New Decade". This course aimed to improve, via virtual classes and a week of intensive training, the participants' skills in Medicinal Chemistry and Chemistry Biology. This course was funded with support from the European Commission and implemented within the framework of Blended Intensive Programmes (BIPs), a new format of Erasmus+ mobility. https://drugdiscovery2030.pt/ (2023/06/26 - 2023/07/12)
Other
 Erasmus Plus, Belgium

Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Centro de Investigação em Química, Portugal

Università degli Studi di Cagliari, Italy

Università degli Studi di Pisa, Italy

Universiteit Gent Faculteit Farmaceutische Wetenschappen, Belgium
2023/04/20 - 2023/04/23 2023 University of Porto Showcase (MostraUP) (2023/04/20 - 2023/04/23)
Exhibition (Co-organisor)
 Universidade do Porto, Portugal
2023/03/31 - 2023/04/03 IX National Encounter of Chemistry Students (2023/03/31 - 2023/04/03)
Meeting (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025/02/26 - 2025/02/28 32nd Young Research Fellows Meeting
Meeting
Société de Chimie Thérapeutique, France

Université Paris Cité UFR de Pharmacie, France
2024/07 - 2024/07 Encontro Ciência 2024
Meeting
Fundação para a Ciência e a Tecnologia, Portugal
2024/06/17 - 2024/06/19 MedChem 2024 - XIII Meeting of the Paul Ehrlich Euro PhD Network
Conference
Università degli Studi di Roma La Sapienza Dipartimento di Chimica e Tecnologia del Farmaco, Italy
2023/07/16 - 2023/07/18 MedChem 2023 - XII Meeting of the Paul Ehrlich Euro PhD Network
Conference
Aristoteleio Panepistemio Thessalonikes Tmema Pharmakeutikes, Greece
2022/11/16 - 2022/11/18 XXVI Galician-Portuguese International Conference on Chemistry
Conference
Universidade de Santiago de Compostela Facultade de Química, Spain
2021/05/05 - 2021/05/07 14th University of Porto Young Research Meeting (IJUP)
Meeting
Universidade do Porto, Portugal
2021/04/23 - 2021/04/23 1st One-Day Meeting on Biotechnology and Synthetic Biology
Meeting
Universidade do Porto Faculdade de Ciências, Portugal
2021/03/06 - 2021/03/06 University Olympiad in Biochemistry COVID-19 Special Edition
Meeting
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03/14 - 2019/03/17 VII AEICBAS Biomedical Congress
Congress
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/03/23 - 2018/03/26 XI National Meeting of Biochemistry Students
Meeting
Universidade do Porto Faculdade de Ciências, Portugal